-- dump date 20140618_191110 -- class Genbank::CDS -- table cds -- table main -- field 1 id -- field 2 GI -- field 3 GeneID -- field 4 chrom_position -- field 5 chromosome -- field 6 codon_start -- field 7 contig -- field 8 description -- field 9 end_pos -- field 10 gene -- field 11 gene_id -- field 12 name -- field 13 organism -- field 14 product -- field 15 protein_id -- field 16 start_pos -- field 17 strand -- field 18 taxid -- field 19 type -- header -- id GI GeneID chrom_position chromosome codon_start contig description end_pos gene gene_id name organism product protein_id start_pos strand taxid type YP_001052714.1 126207489 4848864 63..1547 1 NC_009053.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.; chromosomal replication initiation protein 1547 dnaA 4848864 dnaA Actinobacillus pleuropneumoniae serovar 5b str. L20 chromosomal replication initiation protein YP_001052714.1 63 D 416269 CDS YP_001052715.1 126207490 4848723 1564..2667 1 NC_009053.1 binds the polymerase to DNA and acts as a sliding clamp; DNA polymerase III subunit beta 2667 dnaN 4848723 dnaN Actinobacillus pleuropneumoniae serovar 5b str. L20 DNA polymerase III subunit beta YP_001052715.1 1564 D 416269 CDS YP_001052716.1 126207491 4848972 3001..4083 1 NC_009053.1 Required for DNA replication; binds preferentially to single-stranded, linear DNA; recombination protein F 4083 recF 4848972 recF Actinobacillus pleuropneumoniae serovar 5b str. L20 recombination protein F YP_001052716.1 3001 D 416269 CDS YP_001052717.1 126207492 4850277 complement(4139..4711) 1 NC_009053.1 superoxide dismutase 4711 sodC 4850277 sodC Actinobacillus pleuropneumoniae serovar 5b str. L20 superoxide dismutase YP_001052717.1 4139 R 416269 CDS YP_001052718.1 126207493 4848944 4894..6006 1 NC_009053.1 catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde; aspartate-semialdehyde dehydrogenase 6006 asd 4848944 asd Actinobacillus pleuropneumoniae serovar 5b str. L20 aspartate-semialdehyde dehydrogenase YP_001052718.1 4894 D 416269 CDS YP_001052719.1 126207494 4849612 complement(6134..7264) 1 NC_009053.1 outer membrane protein P2 7264 ompP2A 4849612 ompP2A Actinobacillus pleuropneumoniae serovar 5b str. L20 outer membrane protein P2 YP_001052719.1 6134 R 416269 CDS YP_001052720.1 126207495 4850465 7413..8594 1 NC_009053.1 catalyzes the formation of lipid A disaccharide from UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate, lipid A disaccharide is a precursor of lipid A that anchors LPS to the OM; lipid-A-disaccharide synthase 8594 lpxB 4850465 lpxB Actinobacillus pleuropneumoniae serovar 5b str. L20 lipid-A-disaccharide synthase YP_001052720.1 7413 D 416269 CDS YP_001052721.1 126207496 4849517 8624..9679 1 NC_009053.1 SohB; periplasmic protein; member of the peptidase S49 family; periplasmic protease 9679 sohB 4849517 sohB Actinobacillus pleuropneumoniae serovar 5b str. L20 periplasmic protease YP_001052721.1 8624 D 416269 CDS YP_001052722.1 126207497 4848558 9914..10372 1 NC_009053.1 MraZ; UPF0040; crystal structure shows similarity to AbrB; cell division protein MraZ 10372 4848558 APL_0009 Actinobacillus pleuropneumoniae serovar 5b str. L20 cell division protein MraZ YP_001052722.1 9914 D 416269 CDS YP_001052723.1 126207498 4849206 10398..11339 1 NC_009053.1 S-adenosyl-methyltransferase MraW 11339 mraW 4849206 mraW Actinobacillus pleuropneumoniae serovar 5b str. L20 S-adenosyl-methyltransferase MraW YP_001052723.1 10398 D 416269 CDS YP_001052724.1 126207499 4848698 11352..11666 1 NC_009053.1 cell division protein FtsL 11666 ftsL 4848698 ftsL Actinobacillus pleuropneumoniae serovar 5b str. L20 cell division protein FtsL YP_001052724.1 11352 D 416269 CDS YP_001052725.1 126207500 4849420 11670..13730 1 NC_009053.1 peptidoglycan synthetase FtsI 13730 ftsI 4849420 ftsI Actinobacillus pleuropneumoniae serovar 5b str. L20 peptidoglycan synthetase FtsI YP_001052725.1 11670 D 416269 CDS YP_001052726.1 126207501 4849091 13754..15256 1 NC_009053.1 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate; UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase 15256 murE 4849091 murE Actinobacillus pleuropneumoniae serovar 5b str. L20 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase YP_001052726.1 13754 D 416269 CDS YP_001052727.1 126207502 4849439 15471..16865 1 NC_009053.1 UDP-MurNAc-pentapeptide synthetase 16865 murF 4849439 murF Actinobacillus pleuropneumoniae serovar 5b str. L20 UDP-MurNAc-pentapeptide synthetase YP_001052727.1 15471 D 416269 CDS YP_001052728.1 126207503 4849765 16962..18044 1 NC_009053.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; phospho-N-acetylmuramoyl-pentapeptide- transferase 18044 mraY 4849765 mraY Actinobacillus pleuropneumoniae serovar 5b str. L20 phospho-N-acetylmuramoyl-pentapeptide- transferase YP_001052728.1 16962 D 416269 CDS YP_001052729.1 126207504 4849627 18128..19438 1 NC_009053.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase 19438 murD 4849627 murD Actinobacillus pleuropneumoniae serovar 5b str. L20 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase YP_001052729.1 18128 D 416269 CDS YP_001052730.1 126207505 4848662 19440..20618 1 NC_009053.1 cell division protein FtsW 20618 ftsW 4848662 ftsW Actinobacillus pleuropneumoniae serovar 5b str. L20 cell division protein FtsW YP_001052730.1 19440 D 416269 CDS YP_001052731.1 126207506 4849438 20773..21828 1 NC_009053.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis; undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase 21828 murG 4849438 murG Actinobacillus pleuropneumoniae serovar 5b str. L20 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase YP_001052731.1 20773 D 416269 CDS YP_001052732.1 126207507 4849865 21880..23307 1 NC_009053.1 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis; UDP-N-acetylmuramate--L-alanine ligase 23307 murC 4849865 murC Actinobacillus pleuropneumoniae serovar 5b str. L20 UDP-N-acetylmuramate--L-alanine ligase YP_001052732.1 21880 D 416269 CDS YP_001052733.1 126207508 4849242 23415..24326 1 NC_009053.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanine--D-alanine ligase 24326 ddl 4849242 ddl Actinobacillus pleuropneumoniae serovar 5b str. L20 D-alanine--D-alanine ligase YP_001052733.1 23415 D 416269 CDS YP_001052734.1 126207509 4850111 24467..25120 1 NC_009053.1 cell division protein FtsQ 25120 ftsQ 4850111 ftsQ Actinobacillus pleuropneumoniae serovar 5b str. L20 cell division protein FtsQ YP_001052734.1 24467 D 416269 CDS YP_001052735.1 126207510 4850265 25146..26420 1 NC_009053.1 cell division protein FtsA 26420 ftsA 4850265 ftsA Actinobacillus pleuropneumoniae serovar 5b str. L20 cell division protein FtsA YP_001052735.1 25146 D 416269 CDS YP_001052736.1 126207511 4849860 26459..27670 1 NC_009053.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function; cell division protein FtsZ 27670 ftsZ 4849860 ftsZ Actinobacillus pleuropneumoniae serovar 5b str. L20 cell division protein FtsZ YP_001052736.1 26459 D 416269 CDS YP_001052737.1 126207512 4848703 27704..28624 1 NC_009053.1 zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase 28624 lpxC 4848703 lpxC Actinobacillus pleuropneumoniae serovar 5b str. L20 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase YP_001052737.1 27704 D 416269 CDS YP_001052738.1 126207513 4850036 28786..30459 1 NC_009053.1 DNA repair protein RecN 30459 recN 4850036 recN Actinobacillus pleuropneumoniae serovar 5b str. L20 DNA repair protein RecN YP_001052738.1 28786 D 416269 CDS YP_001052739.1 126207514 4849161 complement(30601..32004) 1 NC_009053.1 ABC transporter ATP-binding protein 32004 4849161 APL_0026 Actinobacillus pleuropneumoniae serovar 5b str. L20 ABC transporter ATP-binding protein YP_001052739.1 30601 R 416269 CDS YP_001052740.1 126207515 4850299 complement(32004..32789) 1 NC_009053.1 nickel transport system permease 32789 4850299 APL_0027 Actinobacillus pleuropneumoniae serovar 5b str. L20 nickel transport system permease YP_001052740.1 32004 R 416269 CDS YP_001052741.1 126207516 4849855 complement(32792..33739) 1 NC_009053.1 ABC transporter permease 33739 4849855 APL_0028 Actinobacillus pleuropneumoniae serovar 5b str. L20 ABC transporter permease YP_001052741.1 32792 R 416269 CDS YP_001052742.1 126207517 4850375 complement(33833..35407) 1 NC_009053.1 ABC transporter periplasmic protein 35407 4850375 APL_0029 Actinobacillus pleuropneumoniae serovar 5b str. L20 ABC transporter periplasmic protein YP_001052742.1 33833 R 416269 CDS YP_001052743.1 126207518 4850473 complement(35601..37181) 1 NC_009053.1 stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein; peptide chain release factor 3 37181 prfC 4850473 prfC Actinobacillus pleuropneumoniae serovar 5b str. L20 peptide chain release factor 3 YP_001052743.1 35601 R 416269 CDS YP_001052744.1 126207519 4848990 37364..37831 1 NC_009053.1 integral membrane protein 37831 4848990 APL_0031 Actinobacillus pleuropneumoniae serovar 5b str. L20 integral membrane protein YP_001052744.1 37364 D 416269 CDS YP_001052745.1 126207520 4849641 37878..38393 1 NC_009053.1 hypothetical protein 38393 yhaH 4849641 yhaH Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001052745.1 37878 D 416269 CDS YP_001052746.1 126207521 4850373 38520..39104 1 NC_009053.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation; peptidyl-tRNA hydrolase 39104 pth 4850373 pth Actinobacillus pleuropneumoniae serovar 5b str. L20 peptidyl-tRNA hydrolase YP_001052746.1 38520 D 416269 CDS YP_001052747.1 126207522 4850367 39213..40304 1 NC_009053.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1; GTP-dependent nucleic acid-binding protein EngD 40304 engD 4850367 engD Actinobacillus pleuropneumoniae serovar 5b str. L20 GTP-dependent nucleic acid-binding protein EngD YP_001052747.1 39213 D 416269 CDS YP_001052748.1 126207523 4848852 40376..40813 1 NC_009053.1 protein-S-isoprenylcysteine methyltransferase 40813 4848852 APL_0035 Actinobacillus pleuropneumoniae serovar 5b str. L20 protein-S-isoprenylcysteine methyltransferase YP_001052748.1 40376 D 416269 CDS YP_001052749.1 126207524 4849023 complement(40863..41138) 1 NC_009053.1 hypothetical protein 41138 4849023 APL_0036 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001052749.1 40863 R 416269 CDS YP_001052750.1 126207525 4849099 complement(41169..41633) 1 NC_009053.1 outer membrane lipoprotein 41633 slyB 4849099 slyB Actinobacillus pleuropneumoniae serovar 5b str. L20 outer membrane lipoprotein YP_001052750.1 41169 R 416269 CDS YP_001052751.1 126207526 4849455 complement(41660..42256) 1 NC_009053.1 hypothetical protein 42256 4849455 APL_0038 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001052751.1 41660 R 416269 CDS YP_001052752.1 126207527 4849485 42435..44081 1 NC_009053.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase; arginyl-tRNA synthetase 44081 argS 4849485 argS Actinobacillus pleuropneumoniae serovar 5b str. L20 arginyl-tRNA synthetase YP_001052752.1 42435 D 416269 CDS YP_001052753.1 126207528 4849935 44225..45400 1 NC_009053.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication; GTPase ObgE 45400 obgE 4849935 obgE Actinobacillus pleuropneumoniae serovar 5b str. L20 GTPase ObgE YP_001052753.1 44225 D 416269 CDS YP_001052754.1 126207529 4850545 45475..46086 1 NC_009053.1 hypothetical protein 46086 4850545 APL_0041 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001052754.1 45475 D 416269 CDS YP_001052755.1 126207530 4849275 complement(46186..46929) 1 NC_009053.1 Specifically methylates the ribose of guanosine 2251 in 23S rRNA; 23S rRNA (guanosine-2'-O-)-methyltransferase 46929 rlmB 4849275 rlmB Actinobacillus pleuropneumoniae serovar 5b str. L20 23S rRNA (guanosine-2'-O-)-methyltransferase YP_001052755.1 46186 R 416269 CDS YP_001052756.1 126207531 4849573 complement(47008..48372) 1 NC_009053.1 catalyzes de novo synthesis of phosphatidylserine from CDP-diacylglycerol and L-serine which leads eventually to the production of phosphatidylethanolamine; bounds to the ribosome; phosphatidylserine synthase 48372 pssA 4849573 pssA Actinobacillus pleuropneumoniae serovar 5b str. L20 phosphatidylserine synthase YP_001052756.1 47008 R 416269 CDS YP_001052757.1 126207532 4849600 complement(48524..51340) 1 NC_009053.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 1 subfamily; some organisms carry two different copies of this enzyme; isoleucyl-tRNA synthetase 51340 ileS 4849600 ileS Actinobacillus pleuropneumoniae serovar 5b str. L20 isoleucyl-tRNA synthetase YP_001052757.1 48524 R 416269 CDS YP_001052758.1 126207533 4849356 complement(51401..52363) 1 NC_009053.1 riboflavin biosynthesis protein 52363 ribF 4849356 ribF Actinobacillus pleuropneumoniae serovar 5b str. L20 riboflavin biosynthesis protein YP_001052758.1 51401 R 416269 CDS YP_001052759.1 126207534 4848774 52696..53976 1 NC_009053.1 catalyzes the formation of NAD(+) from nicotinamide ribonucleotide; nicotinamide-nucleotide adenylyltransferase 53976 nadR 4848774 nadR Actinobacillus pleuropneumoniae serovar 5b str. L20 nicotinamide-nucleotide adenylyltransferase YP_001052759.1 52696 D 416269 CDS YP_001052760.1 126207535 4848487 53973..54671 1 NC_009053.1 diadenosine tetraphosphatase 54671 4848487 APL_0047 Actinobacillus pleuropneumoniae serovar 5b str. L20 diadenosine tetraphosphatase YP_001052760.1 53973 D 416269 CDS YP_001052761.1 126207536 4850431 54844..55560 1 NC_009053.1 two-component response regulator 55560 arcA 4850431 arcA Actinobacillus pleuropneumoniae serovar 5b str. L20 two-component response regulator YP_001052761.1 54844 D 416269 CDS YP_001052762.1 126207537 4848466 55612..56130 1 NC_009053.1 hypothetical protein 56130 4848466 APL_0049 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001052762.1 55612 D 416269 CDS YP_001052763.1 126207538 4848484 complement(56285..57073) 1 NC_009053.1 hypothetical protein 57073 4848484 APL_0050 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001052763.1 56285 R 416269 CDS YP_001052764.1 126207539 4848509 complement(57311..57847) 1 NC_009053.1 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase 57847 4848509 APL_0051 Actinobacillus pleuropneumoniae serovar 5b str. L20 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase YP_001052764.1 57311 R 416269 CDS YP_001052765.1 126207540 4849192 57902..58597 1 NC_009053.1 hypothetical protein 58597 4849192 APL_0052 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001052765.1 57902 D 416269 CDS YP_001052766.1 126207541 4850307 58930..60636 1 NC_009053.1 GTP-binding protein 60636 typA 4850307 typA Actinobacillus pleuropneumoniae serovar 5b str. L20 GTP-binding protein YP_001052766.1 58930 D 416269 CDS YP_001052767.1 126207542 4848965 60795..61058 1 NC_009053.1 functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase; also involved in reducing some disulfides in a coupled system with glutathione reductase; glutaredoxin 61058 grxA 4848965 grxA Actinobacillus pleuropneumoniae serovar 5b str. L20 glutaredoxin YP_001052767.1 60795 D 416269 CDS YP_001052768.1 126207543 4848506 complement(61124..61840) 1 NC_009053.1 RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs; ribonuclease PH 61840 rph 4848506 rph Actinobacillus pleuropneumoniae serovar 5b str. L20 ribonuclease PH YP_001052768.1 61124 R 416269 CDS YP_001052769.1 126207544 4849267 62044..62907 1 NC_009053.1 hypothetical protein 62907 yicC 4849267 yicC Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001052769.1 62044 D 416269 CDS YP_001052770.1 126207545 4848692 62916..63803 1 NC_009053.1 hypothetical protein 63803 4848692 APL_0057 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001052770.1 62916 D 416269 CDS YP_001052771.1 126207546 4849163 complement(63853..64113) 1 NC_009053.1 ferredoxin 64113 yfhL 4849163 yfhL Actinobacillus pleuropneumoniae serovar 5b str. L20 ferredoxin YP_001052771.1 63853 R 416269 CDS YP_001052772.1 126207547 4850420 complement(64259..64888) 1 NC_009053.1 nitrate/nitrite response regulator protein 64888 narP 4850420 narP Actinobacillus pleuropneumoniae serovar 5b str. L20 nitrate/nitrite response regulator protein YP_001052772.1 64259 R 416269 CDS YP_001052773.1 126207548 4850334 65092..67230 1 NC_009053.1 catalyzes the N2-methyl guanosine modification of the G2445 residue of 23S rRNA; 23S rRNA m(2)G2445 methyltransferase 67230 rlmL 4850334 rlmL Actinobacillus pleuropneumoniae serovar 5b str. L20 23S rRNA m(2)G2445 methyltransferase YP_001052773.1 65092 D 416269 CDS YP_001052774.1 126207549 4848512 67288..67767 1 NC_009053.1 tRNA/rRNA methyltransferase 67767 yibK 4848512 yibK Actinobacillus pleuropneumoniae serovar 5b str. L20 tRNA/rRNA methyltransferase YP_001052774.1 67288 D 416269 CDS YP_001052775.1 126207550 4848514 complement(67907..68854) 1 NC_009053.1 transaldolase B 68854 mipB 4848514 mipB Actinobacillus pleuropneumoniae serovar 5b str. L20 transaldolase B YP_001052775.1 67907 R 416269 CDS YP_001052776.1 126207551 4849378 75007..76602 1 NC_009053.1 dipeptide transport protein 76602 dppA 4849378 dppA Actinobacillus pleuropneumoniae serovar 5b str. L20 dipeptide transport protein YP_001052776.1 75007 D 416269 CDS YP_001052777.1 126207552 4849736 76770..78371 1 NC_009053.1 dipeptide transport protein 78371 dppA 4849736 dppA Actinobacillus pleuropneumoniae serovar 5b str. L20 dipeptide transport protein YP_001052777.1 76770 D 416269 CDS YP_001052778.1 126207553 4849592 78499..79503 1 NC_009053.1 dipeptide transport system permease DppB 79503 dppB 4849592 dppB Actinobacillus pleuropneumoniae serovar 5b str. L20 dipeptide transport system permease DppB YP_001052778.1 78499 D 416269 CDS YP_001052779.1 126207554 4849771 79581..80471 1 NC_009053.1 dipeptide transport system permease DppC 80471 dppC 4849771 dppC Actinobacillus pleuropneumoniae serovar 5b str. L20 dipeptide transport system permease DppC YP_001052779.1 79581 D 416269 CDS YP_001052780.1 126207555 4850399 80482..81468 1 NC_009053.1 DppD and DppF are the ATP-binding components of the ABC dipeptide transport system DppABCDF; dipeptide transporter ATP-binding subunit 81468 dppD 4850399 dppD Actinobacillus pleuropneumoniae serovar 5b str. L20 dipeptide transporter ATP-binding subunit YP_001052780.1 80482 D 416269 CDS YP_001052781.1 126207556 4849111 81481..82470 1 NC_009053.1 Part of the ABC transporter complex DppABCDF involved in the transport of dipeptides; dipeptide transporter ATP-binding subunit 82470 dppF 4849111 dppF Actinobacillus pleuropneumoniae serovar 5b str. L20 dipeptide transporter ATP-binding subunit YP_001052781.1 81481 D 416269 CDS YP_001052782.1 126207557 4848646 complement(82543..82953) 1 NC_009053.1 phosphate-starvation-inducible protein PsiE 82953 psiE 4848646 psiE Actinobacillus pleuropneumoniae serovar 5b str. L20 phosphate-starvation-inducible protein PsiE YP_001052782.1 82543 R 416269 CDS YP_001052783.1 126207558 4848660 complement(83031..83663) 1 NC_009053.1 hypothetical protein 83663 4848660 APL_0070 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001052783.1 83031 R 416269 CDS YP_001052784.1 126207559 4848801 complement(83718..84062) 1 NC_009053.1 hypothetical protein 84062 4848801 APL_0071 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001052784.1 83718 R 416269 CDS YP_001052785.1 126207560 4850388 complement(84149..85186) 1 NC_009053.1 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; branched-chain amino acid aminotransferase 85186 ilvE 4850388 ilvE Actinobacillus pleuropneumoniae serovar 5b str. L20 branched-chain amino acid aminotransferase YP_001052785.1 84149 R 416269 CDS YP_001052786.1 126207561 4848705 complement(85329..85655) 1 NC_009053.1 monothiol glutaredoxin-like protein 85655 ydhD 4848705 ydhD Actinobacillus pleuropneumoniae serovar 5b str. L20 monothiol glutaredoxin-like protein YP_001052786.1 85329 R 416269 CDS YP_001052787.1 126207562 4848935 complement(85727..86392) 1 NC_009053.1 involved in a recombinational process of DNA repair, independent of the recBC complex; recombination protein RecR 86392 recR 4848935 recR Actinobacillus pleuropneumoniae serovar 5b str. L20 recombination protein RecR YP_001052787.1 85727 R 416269 CDS YP_001052788.1 126207563 4849372 complement(86403..86732) 1 NC_009053.1 pubmed:14742511; hypothetical protein 86732 ybaB 4849372 ybaB Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001052788.1 86403 R 416269 CDS YP_001052789.1 126207564 4849656 complement(86901..87767) 1 NC_009053.1 pubmed:14742511; protein TonB2 87767 tonB2 4849656 tonB2 Actinobacillus pleuropneumoniae serovar 5b str. L20 protein TonB2 YP_001052789.1 86901 R 416269 CDS YP_001052790.1 126207565 4850227 complement(87777..88166) 1 NC_009053.1 pubmed:14742511; biopolymer transport protein ExbD2 88166 exbD2 4850227 exbD2 Actinobacillus pleuropneumoniae serovar 5b str. L20 biopolymer transport protein ExbD2 YP_001052790.1 87777 R 416269 CDS YP_001052791.1 126207566 4849622 complement(88211..88663) 1 NC_009053.1 pubmed:14742511; biopolymer transport protein ExbB2 88663 exbB2 4849622 exbB2 Actinobacillus pleuropneumoniae serovar 5b str. L20 biopolymer transport protein ExbB2 YP_001052791.1 88211 R 416269 CDS YP_001052792.1 126207567 4849423 88851..89177 1 NC_009053.1 thiosulfate sulfurtransferase GlpE 89177 glpE 4849423 glpE Actinobacillus pleuropneumoniae serovar 5b str. L20 thiosulfate sulfurtransferase GlpE YP_001052792.1 88851 D 416269 CDS YP_001052793.1 126207568 4849473 89221..90066 1 NC_009053.1 thioredoxin-like protein 90066 4849473 APL_0080 Actinobacillus pleuropneumoniae serovar 5b str. L20 thioredoxin-like protein YP_001052793.1 89221 D 416269 CDS YP_001052794.1 126207569 4848860 complement(90141..90548) 1 NC_009053.1 PTS system mannnose-specific transporter subunit IIA 90548 dhaM 4848860 dhaM Actinobacillus pleuropneumoniae serovar 5b str. L20 PTS system mannnose-specific transporter subunit IIA YP_001052794.1 90141 R 416269 CDS YP_001052795.1 126207570 4848917 complement(90557..91183) 1 NC_009053.1 with DhaK and DhaM catalyzes the phosphorylation of dihydroxyacetone; dihydroxyacetone kinase subunit DhaL 91183 dhaL 4848917 dhaL Actinobacillus pleuropneumoniae serovar 5b str. L20 dihydroxyacetone kinase subunit DhaL YP_001052795.1 90557 R 416269 CDS YP_001052796.1 126207571 4850016 complement(91185..92255) 1 NC_009053.1 with DhaL and DhaM forms dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone; DhaK is the dihydroxyacetone binding subunit of the dihydroxyacetone kinase; dihydroxyacetone kinase subunit DhaK 92255 dhaK 4850016 dhaK Actinobacillus pleuropneumoniae serovar 5b str. L20 dihydroxyacetone kinase subunit DhaK YP_001052796.1 91185 R 416269 CDS YP_001052797.1 126207572 4848878 92425..93378 1 NC_009053.1 thioredoxin reductase 93378 trxB 4848878 trxB Actinobacillus pleuropneumoniae serovar 5b str. L20 thioredoxin reductase YP_001052797.1 92425 D 416269 CDS YP_001052798.1 126207573 4850180 93486..94238 1 NC_009053.1 CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS; 3-deoxy-manno-octulosonate cytidylyltransferase 94238 kdsB 4850180 kdsB Actinobacillus pleuropneumoniae serovar 5b str. L20 3-deoxy-manno-octulosonate cytidylyltransferase YP_001052798.1 93486 D 416269 CDS YP_001052799.1 126207574 4848829 94362..94787 1 NC_009053.1 hypothetical protein 94787 4848829 APL_0086 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001052799.1 94362 D 416269 CDS YP_001052800.1 126207575 4849752 complement(94861..95631) 1 NC_009053.1 can catalyze hydrolysis of broad range of dinucleotide pyrophosphates but prefers reduced form of NADH; requires divalent metal ions such as magnesium and manganese and produces two mononucleoside 5'-phosphates; NADH pyrophosphatase 95631 nudC 4849752 nudC Actinobacillus pleuropneumoniae serovar 5b str. L20 NADH pyrophosphatase YP_001052800.1 94861 R 416269 CDS YP_001052801.1 126207576 4849869 complement(95649..96344) 1 NC_009053.1 ribosomal large subunit pseudouridine synthase E 96344 rluE 4849869 rluE Actinobacillus pleuropneumoniae serovar 5b str. L20 ribosomal large subunit pseudouridine synthase E YP_001052801.1 95649 R 416269 CDS YP_001052802.1 126207577 4850548 complement(96348..97166) 1 NC_009053.1 hypothetical protein 97166 rhaT 4850548 rhaT Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001052802.1 96348 R 416269 CDS YP_001052803.1 126207578 4850415 complement(97196..97660) 1 NC_009053.1 hypothetical protein 97660 4850415 APL_0090 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001052803.1 97196 R 416269 CDS YP_001052804.1 126207579 4850267 complement(97683..99014) 1 NC_009053.1 catalyzes the hydrolysis of dipeptides with a proline at the C-terminal; also catalyzes the low efficiency hydrolysis of organophosphate di- and tri-esters; proline dipeptidase 99014 pepQ 4850267 pepQ Actinobacillus pleuropneumoniae serovar 5b str. L20 proline dipeptidase YP_001052804.1 97683 R 416269 CDS YP_001052805.1 126207580 4850253 99038..99277 1 NC_009053.1 TusA; transfers sulfur to TusBCD complex; involved in thiouridation of U34 position of some tRNAs; sulfur transfer protein SirA 99277 sirA 4850253 sirA Actinobacillus pleuropneumoniae serovar 5b str. L20 sulfur transfer protein SirA YP_001052805.1 99038 D 416269 CDS YP_001052806.1 126207581 4850458 complement(99327..99767) 1 NC_009053.1 hypothetical protein 99767 4850458 APL_0093 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001052806.1 99327 R 416269 CDS YP_001052807.1 126207582 4850562 complement(99769..100389) 1 NC_009053.1 binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential; ribosome biogenesis GTP-binding protein YsxC 100389 engB 4850562 engB Actinobacillus pleuropneumoniae serovar 5b str. L20 ribosome biogenesis GTP-binding protein YsxC YP_001052807.1 99769 R 416269 CDS YP_001052808.1 126207583 4850025 complement(100684..101100) 1 NC_009053.1 hypothetical protein 101100 4850025 APL_0095 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001052808.1 100684 R 416269 CDS YP_001052809.1 126207584 4849744 complement(101138..101968) 1 NC_009053.1 zinc transporter family protein ZIP 101968 4849744 APL_0096 Actinobacillus pleuropneumoniae serovar 5b str. L20 zinc transporter family protein ZIP YP_001052809.1 101138 R 416269 CDS YP_001052810.1 126207585 4849997 complement(102119..103954) 1 NC_009053.1 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; dihydroxy-acid dehydratase 103954 ilvD 4849997 ilvD Actinobacillus pleuropneumoniae serovar 5b str. L20 dihydroxy-acid dehydratase YP_001052810.1 102119 R 416269 CDS YP_001052811.1 126207586 4848715 complement(104072..104290) 1 NC_009053.1 acetolactate synthase 2 regulatory subunit 104290 ilvM 4848715 ilvM Actinobacillus pleuropneumoniae serovar 5b str. L20 acetolactate synthase 2 regulatory subunit YP_001052811.1 104072 R 416269 CDS YP_001052812.1 126207587 4848528 complement(104311..105810) 1 NC_009053.1 acetolactate synthase isozyme II large subunit 105810 ilvG 4848528 ilvG Actinobacillus pleuropneumoniae serovar 5b str. L20 acetolactate synthase isozyme II large subunit YP_001052812.1 104311 R 416269 CDS YP_001052813.1 126207588 4849298 106390..107871 1 NC_009053.1 catalyzes the formate-dependent reduction of nitrite to ammonia; cytochrome C552; cytochrome c552 107871 nrfA 4849298 nrfA Actinobacillus pleuropneumoniae serovar 5b str. L20 cytochrome c552 YP_001052813.1 106390 D 416269 CDS YP_001052814.1 126207589 4849077 107892..108539 1 NC_009053.1 part of nitrite reductase complex; NrfB is active at high nitrate conditions; NrfA, B, C, and D are essential for the formate-dependent nitrite reduction to ammonia; cytochrome c nitrite reductase pentaheme subunit 108539 nrfB 4849077 nrfB Actinobacillus pleuropneumoniae serovar 5b str. L20 cytochrome c nitrite reductase pentaheme subunit YP_001052814.1 107892 D 416269 CDS YP_001052815.1 126207590 4849381 108539..109216 1 NC_009053.1 nitrate reductase 109216 nrfC 4849381 nrfC Actinobacillus pleuropneumoniae serovar 5b str. L20 nitrate reductase YP_001052815.1 108539 D 416269 CDS YP_001052816.1 126207591 4849924 109216..110184 1 NC_009053.1 nitrite reductase transmembrane protein 110184 nrfD 4849924 nrfD Actinobacillus pleuropneumoniae serovar 5b str. L20 nitrite reductase transmembrane protein YP_001052816.1 109216 D 416269 CDS YP_001052817.1 126207592 4849579 110472..119936 1 NC_009053.1 autotransporter adhesin 119936 4849579 APL_0104 Actinobacillus pleuropneumoniae serovar 5b str. L20 autotransporter adhesin YP_001052817.1 110472 D 416269 CDS YP_001052818.1 126207593 4848529 complement(120177..121406) 1 NC_009053.1 uracil permease 121406 uraA 4848529 uraA Actinobacillus pleuropneumoniae serovar 5b str. L20 uracil permease YP_001052818.1 120177 R 416269 CDS YP_001052819.1 126207594 4850443 complement(121566..125171) 1 NC_009053.1 proline utilization protein A; multifunctional protein that functions in proline catabolism in the first two enzymatic steps resulting in the conversion of proline to glutamate; in Escherichia coli this protein self regulates transcription via a DNA-binding domain at the N-terminus but the protein from Pseudomonas does not have this domain; bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase 125171 putA 4850443 putA Actinobacillus pleuropneumoniae serovar 5b str. L20 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase YP_001052819.1 121566 R 416269 CDS YP_001052820.1 126207595 4849239 complement(125274..126788) 1 NC_009053.1 sodium/proline symporter 126788 putP 4849239 putP Actinobacillus pleuropneumoniae serovar 5b str. L20 sodium/proline symporter YP_001052820.1 125274 R 416269 CDS YP_001052821.1 126207596 4850533 complement(127363..128148) 1 NC_009053.1 HTH-type transcriptional regulator 128148 iclR 4850533 iclR Actinobacillus pleuropneumoniae serovar 5b str. L20 HTH-type transcriptional regulator YP_001052821.1 127363 R 416269 CDS YP_001052822.1 126207597 4849384 complement(128145..128720) 1 NC_009053.1 hypothetical protein 128720 4849384 APL_0109 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001052822.1 128145 R 416269 CDS YP_001052823.1 126207598 4850432 complement(128991..129311) 1 NC_009053.1 hypothetical protein 129311 4850432 APL_0110 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001052823.1 128991 R 416269 CDS YP_001052824.1 126207599 4848757 129389..129940 1 NC_009053.1 hypothetical protein 129940 4848757 APL_0111 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001052824.1 129389 D 416269 CDS YP_001052825.1 126207600 4849940 130046..131110 1 NC_009053.1 catalyzes the formation of coproporphyrinogen from uroporphyrinogen III; uroporphyrinogen decarboxylase 131110 hemE 4849940 hemE Actinobacillus pleuropneumoniae serovar 5b str. L20 uroporphyrinogen decarboxylase YP_001052825.1 130046 D 416269 CDS YP_001052826.1 126207601 4848468 131234..131824 1 NC_009053.1 hypothetical protein 131824 4848468 APL_0113 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001052826.1 131234 D 416269 CDS YP_001052827.1 126207602 4850001 131960..132232 1 NC_009053.1 DNA-binding protein HU 132232 hupA 4850001 hupA Actinobacillus pleuropneumoniae serovar 5b str. L20 DNA-binding protein HU YP_001052827.1 131960 D 416269 CDS YP_001052828.1 126207603 4850429 complement(132285..133136) 1 NC_009053.1 ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived; thymidylate synthase 133136 thyA 4850429 thyA Actinobacillus pleuropneumoniae serovar 5b str. L20 thymidylate synthase YP_001052828.1 132285 R 416269 CDS YP_001052829.1 126207604 4848786 133224..133808 1 NC_009053.1 hypothetical protein 133808 4848786 APL_0116 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001052829.1 133224 D 416269 CDS YP_001052830.1 126207605 4849847 133904..134914 1 NC_009053.1 biotin synthase 134914 bioB 4849847 bioB Actinobacillus pleuropneumoniae serovar 5b str. L20 biotin synthase YP_001052830.1 133904 D 416269 CDS YP_001052831.1 126207606 4850298 complement(134978..135187) 1 NC_009053.1 cold shock-like protein CspC 135187 cspC 4850298 cspC Actinobacillus pleuropneumoniae serovar 5b str. L20 cold shock-like protein CspC YP_001052831.1 134978 R 416269 CDS YP_001052832.1 126207607 4848877 135550..136098 1 NC_009053.1 affects solute and DNA transport through an unknown mechanism; solute/DNA competence effector 136098 proQ 4848877 proQ Actinobacillus pleuropneumoniae serovar 5b str. L20 solute/DNA competence effector YP_001052832.1 135550 D 416269 CDS YP_001052833.1 126207608 4849922 136190..138202 1 NC_009053.1 Involved in the cleavage of a C-terminal peptide of 11 residues from the precursor form of penicillin-binding protein 3; carboxy-terminal protease 138202 prc 4849922 prc Actinobacillus pleuropneumoniae serovar 5b str. L20 carboxy-terminal protease YP_001052833.1 136190 D 416269 CDS YP_001052834.1 126207609 4848724 138299..139864 1 NC_009053.1 hypothetical protein 139864 4848724 APL_0121 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001052834.1 138299 D 416269 CDS YP_001052835.1 126207610 4849154 140036..140590 1 NC_009053.1 hypothetical protein 140590 4849154 APL_0122 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001052835.1 140036 D 416269 CDS YP_001052836.1 126207611 4850418 140608..141237 1 NC_009053.1 glyoxalase II family protein 141237 4850418 APL_0123 Actinobacillus pleuropneumoniae serovar 5b str. L20 glyoxalase II family protein YP_001052836.1 140608 D 416269 CDS YP_001052837.1 126207612 4849767 complement(141240..141989) 1 NC_009053.1 hypothetical protein 141989 4849767 APL_0124 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001052837.1 141240 R 416269 CDS YP_001052838.1 126207613 4850306 complement(141986..142360) 1 NC_009053.1 hypothetical protein 142360 4850306 APL_0125 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001052838.1 141986 R 416269 CDS YP_001052839.1 126207614 4849657 complement(142362..142727) 1 NC_009053.1 HIT-like protein 142727 4849657 APL_0126 Actinobacillus pleuropneumoniae serovar 5b str. L20 HIT-like protein YP_001052839.1 142362 R 416269 CDS YP_001052840.1 126207615 4849141 complement(142799..143629) 1 NC_009053.1 iron transport system membrane protein 143629 yfeD 4849141 yfeD Actinobacillus pleuropneumoniae serovar 5b str. L20 iron transport system membrane protein YP_001052840.1 142799 R 416269 CDS YP_001052841.1 126207616 4850468 complement(143622..144476) 1 NC_009053.1 iron transport system membrane protein 144476 yfeC 4850468 yfeC Actinobacillus pleuropneumoniae serovar 5b str. L20 iron transport system membrane protein YP_001052841.1 143622 R 416269 CDS YP_001052842.1 126207617 4850382 complement(144477..145070) 1 NC_009053.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids; ribonuclease HII 145070 rnhB 4850382 rnhB Actinobacillus pleuropneumoniae serovar 5b str. L20 ribonuclease HII YP_001052842.1 144477 R 416269 CDS YP_001052843.1 126207618 4848826 complement(145093..146127) 1 NC_009053.1 EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity; ribosome-associated GTPase 146127 engC 4848826 engC Actinobacillus pleuropneumoniae serovar 5b str. L20 ribosome-associated GTPase YP_001052843.1 145093 R 416269 CDS YP_001052844.1 126207619 4848555 146637..147527 1 NC_009053.1 Glycine cleavage system transcriptional activator; activates the gcvTHP operon in the presence of glycine and represses the operon in its absence; DNA-binding transcriptional activator GcvA 147527 gcvA 4848555 gcvA Actinobacillus pleuropneumoniae serovar 5b str. L20 DNA-binding transcriptional activator GcvA YP_001052844.1 146637 D 416269 CDS YP_001052845.1 126207620 4849778 147527..148207 1 NC_009053.1 manganese-dependent 5'-nucleotidase; specific for 5'-UMP, 5'-dUMP, and 5'-dTMP; member of haloacid dehalogenase (HAD)-like hydrolase superfamily; nucleotidase 148207 4849778 APL_0132 Actinobacillus pleuropneumoniae serovar 5b str. L20 nucleotidase YP_001052845.1 147527 D 416269 CDS YP_001052846.1 126207621 4849948 148207..149190 1 NC_009053.1 LysR-type transcriptional regulator; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates cysteine biosynthesis by controlling expression of the cys regulon; autoregulates expression; crystal structure of Klebsiella aerogenes showed tetramer formation; transcriptional regulator CysB 149190 cysB 4849948 cysB Actinobacillus pleuropneumoniae serovar 5b str. L20 transcriptional regulator CysB YP_001052846.1 148207 D 416269 CDS YP_001052847.1 126207622 4848959 149191..149835 1 NC_009053.1 hypothetical protein 149835 4848959 APL_0134 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001052847.1 149191 D 416269 CDS YP_001052848.1 126207623 4849926 complement(149916..150965) 1 NC_009053.1 catalyzes the formation of aspartate from asparagine, periplasmic; regulated by cyclic AMP receptor protein (CRP) and also induced by anaerobiosis; L-asparaginase II 150965 ansB 4849926 ansB Actinobacillus pleuropneumoniae serovar 5b str. L20 L-asparaginase II YP_001052848.1 149916 R 416269 CDS YP_001052849.1 126207624 4848586 151269..152906 1 NC_009053.1 CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer; CTP synthetase 152906 pyrG 4848586 pyrG Actinobacillus pleuropneumoniae serovar 5b str. L20 CTP synthetase YP_001052849.1 151269 D 416269 CDS YP_001052850.1 126207625 4849795 153009..153515 1 NC_009053.1 hypothetical protein 153515 4849795 APL_0137 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001052850.1 153009 D 416269 CDS YP_001052851.1 126207626 4849167 complement(153561..154163) 1 NC_009053.1 catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D; isopropylmalate isomerase small subunit 154163 leuD 4849167 leuD Actinobacillus pleuropneumoniae serovar 5b str. L20 isopropylmalate isomerase small subunit YP_001052851.1 153561 R 416269 CDS YP_001052852.1 126207627 4848700 complement(154174..155583) 1 NC_009053.1 dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; isopropylmalate isomerase large subunit 155583 leuC 4848700 leuC Actinobacillus pleuropneumoniae serovar 5b str. L20 isopropylmalate isomerase large subunit YP_001052852.1 154174 R 416269 CDS YP_001052853.1 126207628 4849272 155925..157040 1 NC_009053.1 hypothetical protein 157040 4849272 APL_0140 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001052853.1 155925 D 416269 CDS YP_001052854.1 126207629 4848973 157168..158430 1 NC_009053.1 hypothetical protein 158430 4848973 APL_0141 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001052854.1 157168 D 416269 CDS YP_001052855.1 126207630 4850276 158441..159574 1 NC_009053.1 glycerate kinase 159574 glxK 4850276 glxK Actinobacillus pleuropneumoniae serovar 5b str. L20 glycerate kinase YP_001052855.1 158441 D 416269 CDS YP_001052856.1 126207631 4849368 159593..159865 1 NC_009053.1 catalyzes the hydrolysis of acylphosphate; acylphosphatase 159865 4849368 APL_0143 Actinobacillus pleuropneumoniae serovar 5b str. L20 acylphosphatase YP_001052856.1 159593 D 416269 CDS YP_001052857.1 126207632 4849883 complement(159936..161495) 1 NC_009053.1 ATP-dependent endonuclease 161495 4849883 APL_0144 Actinobacillus pleuropneumoniae serovar 5b str. L20 ATP-dependent endonuclease YP_001052857.1 159936 R 416269 CDS YP_001052858.1 126207633 4849240 complement(161499..162878) 1 NC_009053.1 hypothetical protein 162878 4849240 APL_0145 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001052858.1 161499 R 416269 CDS YP_001052859.1 126207634 4848620 complement(162938..163915) 1 NC_009053.1 tRNA-dihydrouridine synthase A 163915 dusA 4848620 dusA Actinobacillus pleuropneumoniae serovar 5b str. L20 tRNA-dihydrouridine synthase A YP_001052859.1 162938 R 416269 CDS YP_001052860.1 126207635 4848713 164268..165245 1 NC_009053.1 ribonucleoside-diphosphate reductase subunit beta 165245 4848713 APL_0147 Actinobacillus pleuropneumoniae serovar 5b str. L20 ribonucleoside-diphosphate reductase subunit beta YP_001052860.1 164268 D 416269 CDS YP_001052861.1 126207636 4849431 165232..166896 1 NC_009053.1 Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 166896 rnr1 4849431 rnr1 Actinobacillus pleuropneumoniae serovar 5b str. L20 ribonucleotide-diphosphate reductase subunit alpha YP_001052861.1 165232 D 416269 CDS YP_001052862.1 126207637 4850137 complement(167032..167631) 1 NC_009053.1 cytoplasmic protein that may be involved in the utilization of double-stranded DNA as a carbon source; DNA uptake protein 167631 4850137 APL_0149 Actinobacillus pleuropneumoniae serovar 5b str. L20 DNA uptake protein YP_001052862.1 167032 R 416269 CDS YP_001052863.1 126207638 4848604 168086..169435 1 NC_009053.1 uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm; Na(+)-translocating NADH-quinone reductase subunit A 169435 nqrA 4848604 nqrA Actinobacillus pleuropneumoniae serovar 5b str. L20 Na(+)-translocating NADH-quinone reductase subunit A YP_001052863.1 168086 D 416269 CDS YP_001052864.1 126207639 4850490 169440..170672 1 NC_009053.1 uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm; Na(+)-translocating NADH-quinone reductase subunit B 170672 nqrB 4850490 nqrB Actinobacillus pleuropneumoniae serovar 5b str. L20 Na(+)-translocating NADH-quinone reductase subunit B YP_001052864.1 169440 D 416269 CDS YP_001052865.1 126207640 4850114 170675..171448 1 NC_009053.1 uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm; Na(+)-translocating NADH-quinone reductase subunit C 171448 nqrC 4850114 nqrC Actinobacillus pleuropneumoniae serovar 5b str. L20 Na(+)-translocating NADH-quinone reductase subunit C YP_001052865.1 170675 D 416269 CDS YP_001052866.1 126207641 4850337 171448..172071 1 NC_009053.1 Part of the NQR complex which catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm; Na(+)-translocating NADH-quinone reductase subunit D 172071 nqrD 4850337 nqrD Actinobacillus pleuropneumoniae serovar 5b str. L20 Na(+)-translocating NADH-quinone reductase subunit D YP_001052866.1 171448 D 416269 CDS YP_001052867.1 126207642 4848756 172073..172669 1 NC_009053.1 Part of the NQR complex which consists of NqrA, NqrB, NqrC, NqrD, NqrE and NqrF; NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm; NqrE is probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.; Na(+)-translocating NADH-quinone reductase subunit E 172669 nqrE 4848756 nqrE Actinobacillus pleuropneumoniae serovar 5b str. L20 Na(+)-translocating NADH-quinone reductase subunit E YP_001052867.1 172073 D 416269 CDS YP_001052868.1 126207643 4848745 172680..173909 1 NC_009053.1 uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm; Na(+)-translocating NADH-quinone reductase subunit F 173909 nqrF 4848745 nqrF Actinobacillus pleuropneumoniae serovar 5b str. L20 Na(+)-translocating NADH-quinone reductase subunit F YP_001052868.1 172680 D 416269 CDS YP_001052869.1 126207644 4849574 174116..175147 1 NC_009053.1 thiamine biosynthesis lipoprotein ApbE 175147 apbE 4849574 apbE Actinobacillus pleuropneumoniae serovar 5b str. L20 thiamine biosynthesis lipoprotein ApbE YP_001052869.1 174116 D 416269 CDS YP_001052870.1 126207645 4849639 175160..175405 1 NC_009053.1 hypothetical protein 175405 4849639 APL_0157 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001052870.1 175160 D 416269 CDS YP_001052871.1 126207646 4848961 175634..176803 1 NC_009053.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs; tRNA-specific 2-thiouridylase MnmA 176803 mnmA 4848961 mnmA Actinobacillus pleuropneumoniae serovar 5b str. L20 tRNA-specific 2-thiouridylase MnmA YP_001052871.1 175634 D 416269 CDS YP_001052872.1 126207647 4848879 complement(176876..178030) 1 NC_009053.1 putative transporter of 3-phenylpropionate across the inner membrane; member of the major facilitator superfamily of transporters; 3-phenylpropionic acid transporter 178030 hcaT 4848879 hcaT Actinobacillus pleuropneumoniae serovar 5b str. L20 3-phenylpropionic acid transporter YP_001052872.1 176876 R 416269 CDS YP_001052873.1 126207648 4849218 complement(178027..178857) 1 NC_009053.1 pyrroline-5-carboxylate reductase 178857 proC 4849218 proC Actinobacillus pleuropneumoniae serovar 5b str. L20 pyrroline-5-carboxylate reductase YP_001052873.1 178027 R 416269 CDS YP_001052874.1 126207649 4850196 179020..179928 1 NC_009053.1 Required for efficient pilin antigenic variation; recombination associated protein 179928 rdgC 4850196 rdgC Actinobacillus pleuropneumoniae serovar 5b str. L20 recombination associated protein YP_001052874.1 179020 D 416269 CDS YP_001052875.1 126207650 4848789 179938..180543 1 NC_009053.1 phosphatase 180543 4848789 APL_0162 Actinobacillus pleuropneumoniae serovar 5b str. L20 phosphatase YP_001052875.1 179938 D 416269 CDS YP_001052876.1 126207651 4850074 complement(180719..182578) 1 NC_009053.1 Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates; anaerobic ribonucleoside triphosphate reductase 182578 4850074 APL_0163 Actinobacillus pleuropneumoniae serovar 5b str. L20 anaerobic ribonucleoside triphosphate reductase YP_001052876.1 180719 R 416269 CDS YP_001052877.1 126207652 4848989 complement(182583..183050) 1 NC_009053.1 hypothetical protein 183050 4848989 APL_0164 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001052877.1 182583 R 416269 CDS YP_001052878.1 126207653 4849320 183432..184013 1 NC_009053.1 Na(+)-translocating NADH-quinone reductase subunit E 184013 rnfA 4849320 rnfA Actinobacillus pleuropneumoniae serovar 5b str. L20 Na(+)-translocating NADH-quinone reductase subunit E YP_001052878.1 183432 D 416269 CDS YP_001052879.1 126207654 4850292 184034..184624 1 NC_009053.1 part of membrane-bound complex thought to be involved in electron transport to nitrogen; electron transport complex protein RnfB 184624 rnfB 4850292 rnfB Actinobacillus pleuropneumoniae serovar 5b str. L20 electron transport complex protein RnfB YP_001052879.1 184034 D 416269 CDS YP_001052880.1 126207655 4850091 184617..186929 1 NC_009053.1 part of membrane-bound complex thought to be involved in electron transport to nitrogen; electron transport complex protein RnfC 186929 rnfC 4850091 rnfC Actinobacillus pleuropneumoniae serovar 5b str. L20 electron transport complex protein RnfC YP_001052880.1 184617 D 416269 CDS YP_001052881.1 126207656 4849098 186922..187566 1 NC_009053.1 hypothetical protein 187566 4849098 APL_0168 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001052881.1 186922 D 416269 CDS YP_001052882.1 126207657 4849268 187586..188632 1 NC_009053.1 RnfD; RsxD; required for nitrogen fixation in Rhodobacter capsulatus; part of a membrane-bound complex thought to be involved in electron transport to nitrogenase; in Escherichia coli this gene is part of a cluster controlling SoxR-mediated induction of the SoxS transcription factor in the absence of oxidizing agents; electron transport complex protein RnfD 188632 rnfD 4849268 rnfD Actinobacillus pleuropneumoniae serovar 5b str. L20 electron transport complex protein RnfD YP_001052882.1 187586 D 416269 CDS YP_001052883.1 126207658 4849174 188632..189264 1 NC_009053.1 part of membrane-bound complex hought to be involved in electron transport to nitrogen; electron transport complex protein RnfG 189264 rnfG 4849174 rnfG Actinobacillus pleuropneumoniae serovar 5b str. L20 electron transport complex protein RnfG YP_001052883.1 188632 D 416269 CDS YP_001052884.1 126207659 4849181 189276..189962 1 NC_009053.1 in Excherichia coli RsxABCDEG reduces SoxR which turns off induction of SoxS transcription factor in the absence of oxidizing agents; similar to the rnfABCDGE operon in Rhodobacter capsulatus involved in transferring electrons to nitrogenase; electron transport complex protein RsxE 189962 rnfE 4849181 rnfE Actinobacillus pleuropneumoniae serovar 5b str. L20 electron transport complex protein RsxE YP_001052884.1 189276 D 416269 CDS YP_001052885.1 126207660 4849294 189971..190927 1 NC_009053.1 Transfers myristate or laurate, activated on ACP, to the lipid IVA moiety of (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase 190927 msbB 4849294 msbB Actinobacillus pleuropneumoniae serovar 5b str. L20 lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase YP_001052885.1 189971 D 416269 CDS YP_001052886.1 126207661 4849297 complement(190987..191973) 1 NC_009053.1 hypothetical protein 191973 4849297 APL_0173 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001052886.1 190987 R 416269 CDS YP_001052887.1 126207662 4848929 192415..193380 1 NC_009053.1 thiamine-binding periplasmic protein 193380 tbpA 4848929 tbpA Actinobacillus pleuropneumoniae serovar 5b str. L20 thiamine-binding periplasmic protein YP_001052887.1 192415 D 416269 CDS YP_001052888.1 126207663 4848733 193587..194036 1 NC_009053.1 DnaK suppressor protein 194036 dksA 4848733 dksA Actinobacillus pleuropneumoniae serovar 5b str. L20 DnaK suppressor protein YP_001052888.1 193587 D 416269 CDS YP_001052889.1 126207664 4850168 194179..195711 1 NC_009053.1 poly(A) polymerase 195711 pcnB 4850168 pcnB Actinobacillus pleuropneumoniae serovar 5b str. L20 poly(A) polymerase YP_001052889.1 194179 D 416269 CDS YP_001052890.1 126207665 4849273 195781..196251 1 NC_009053.1 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase 196251 folK 4849273 folK Actinobacillus pleuropneumoniae serovar 5b str. L20 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase YP_001052890.1 195781 D 416269 CDS YP_001052891.1 126207666 4849590 complement(196289..196510) 1 NC_009053.1 hypothetical protein 196510 4849590 APL_0178 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001052891.1 196289 R 416269 CDS YP_001052892.1 126207667 4849589 complement(196507..199203) 1 NC_009053.1 hypothetical protein 199203 4849589 APL_0179 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001052892.1 196507 R 416269 CDS YP_001052893.1 126207668 4850195 complement(199236..200000) 1 NC_009053.1 hypothetical protein 200000 4850195 APL_0180 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001052893.1 199236 R 416269 CDS YP_001052894.1 126207669 4849951 200154..200561 1 NC_009053.1 lactoylglutathione lyase 200561 gloA 4849951 gloA Actinobacillus pleuropneumoniae serovar 5b str. L20 lactoylglutathione lyase YP_001052894.1 200154 D 416269 CDS YP_001052895.1 126207670 4848650 200701..201357 1 NC_009053.1 Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A); ribonuclease T 201357 dnaQ 4848650 dnaQ Actinobacillus pleuropneumoniae serovar 5b str. L20 ribonuclease T YP_001052895.1 200701 D 416269 CDS YP_001052896.1 126207671 4849311 complement(201448..202725) 1 NC_009053.1 Mn2+/Fe2+ transporter 202725 4849311 APL_0183 Actinobacillus pleuropneumoniae serovar 5b str. L20 Mn2+/Fe2+ transporter YP_001052896.1 201448 R 416269 CDS YP_001052897.1 126207672 4849979 complement(203301..204422) 1 NC_009053.1 catalyzes the formation of prephenate from chorismate and the formation of 4-hydroxyphenylpyruvate from prephenate in tyrosine biosynthesis; bifunctional chorismate mutase/prephenate dehydrogenase 204422 tyrA 4849979 tyrA Actinobacillus pleuropneumoniae serovar 5b str. L20 bifunctional chorismate mutase/prephenate dehydrogenase YP_001052897.1 203301 R 416269 CDS YP_001052898.1 126207673 4848729 complement(204535..205596) 1 NC_009053.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, tyrosine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase 205596 aroF 4848729 aroF Actinobacillus pleuropneumoniae serovar 5b str. L20 phospho-2-dehydro-3-deoxyheptonate aldolase YP_001052898.1 204535 R 416269 CDS YP_001052899.1 126207674 4848721 complement(205638..206684) 1 NC_009053.1 ADP-heptose--LPS heptosyltransferase 206684 4848721 APL_0186 Actinobacillus pleuropneumoniae serovar 5b str. L20 ADP-heptose--LPS heptosyltransferase YP_001052899.1 205638 R 416269 CDS YP_001052900.1 126207675 4849495 complement(206772..208211) 1 NC_009053.1 pyruvate kinase 208211 pykA 4849495 pykA Actinobacillus pleuropneumoniae serovar 5b str. L20 pyruvate kinase YP_001052900.1 206772 R 416269 CDS YP_001052901.1 126207676 4849543 208343..208834 1 NC_009053.1 phosphohistidine phosphatase 208834 sixA 4849543 sixA Actinobacillus pleuropneumoniae serovar 5b str. L20 phosphohistidine phosphatase YP_001052901.1 208343 D 416269 CDS YP_001052902.1 126207677 4849811 209057..210019 1 NC_009053.1 tRNA-dihydrouridine synthase B 210019 dus 4849811 dus Actinobacillus pleuropneumoniae serovar 5b str. L20 tRNA-dihydrouridine synthase B YP_001052902.1 209057 D 416269 CDS YP_001052903.1 126207678 4849061 210047..210343 1 NC_009053.1 Stimulates excision of phage lambda; affects Mu development; acts as an activator of rRNA and iRNA transcription; DNA-binding protein Fis 210343 fis 4849061 fis Actinobacillus pleuropneumoniae serovar 5b str. L20 DNA-binding protein Fis YP_001052903.1 210047 D 416269 CDS YP_001052904.1 126207679 4849377 complement(210408..211766) 1 NC_009053.1 SNF family Na+-dependent transporter 211766 4849377 APL_0191 Actinobacillus pleuropneumoniae serovar 5b str. L20 SNF family Na+-dependent transporter YP_001052904.1 210408 R 416269 CDS YP_001052905.1 126207680 4850113 complement(211831..212664) 1 NC_009053.1 DNA adenine methylase 212664 dam 4850113 dam Actinobacillus pleuropneumoniae serovar 5b str. L20 DNA adenine methylase YP_001052905.1 211831 R 416269 CDS YP_001052906.1 126207681 4849357 complement(212657..213757) 1 NC_009053.1 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis; 3-dehydroquinate synthase 213757 aroB 4849357 aroB Actinobacillus pleuropneumoniae serovar 5b str. L20 3-dehydroquinate synthase YP_001052906.1 212657 R 416269 CDS YP_001052907.1 126207682 4849931 complement(213831..214352) 1 NC_009053.1 catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis; shikimate kinase 214352 aroK 4849931 aroK Actinobacillus pleuropneumoniae serovar 5b str. L20 shikimate kinase YP_001052907.1 213831 R 416269 CDS YP_001052908.1 126207683 4849608 complement(214614..217181) 1 NC_009053.1 membrane carboxypeptidase/penicillin-binding protein 217181 mrcA 4849608 mrcA Actinobacillus pleuropneumoniae serovar 5b str. L20 membrane carboxypeptidase/penicillin-binding protein YP_001052908.1 214614 R 416269 CDS YP_001052909.1 126207684 4849432 217320..218000 1 NC_009053.1 hypothetical protein 218000 4849432 APL_0196 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001052909.1 217320 D 416269 CDS YP_001052910.1 126207685 4850377 218072..218503 1 NC_009053.1 hypothetical protein 218503 4850377 APL_0197 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001052910.1 218072 D 416269 CDS YP_001052911.1 126207686 4850078 218506..219033 1 NC_009053.1 hypothetical protein 219033 4850078 APL_0198 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001052911.1 218506 D 416269 CDS YP_001052912.1 126207687 4848727 219026..219430 1 NC_009053.1 hypothetical protein 219430 4848727 APL_0199 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001052912.1 219026 D 416269 CDS YP_001052913.1 126207688 4849326 219442..220740 1 NC_009053.1 type II secretory pathway, component HofQ 220740 hofQ 4849326 hofQ Actinobacillus pleuropneumoniae serovar 5b str. L20 type II secretory pathway, component HofQ YP_001052913.1 219442 D 416269 CDS YP_001052914.1 126207689 4850347 220866..221279 1 NC_009053.1 Regulates rRNA biosynthesis by transcriptional antitermination; transcription antitermination protein NusB 221279 nusB 4850347 nusB Actinobacillus pleuropneumoniae serovar 5b str. L20 transcription antitermination protein NusB YP_001052914.1 220866 D 416269 CDS YP_001052915.1 126207690 4849002 221347..222309 1 NC_009053.1 thiamine-monophosphate kinase 222309 thiL 4849002 thiL Actinobacillus pleuropneumoniae serovar 5b str. L20 thiamine-monophosphate kinase YP_001052915.1 221347 D 416269 CDS YP_001052916.1 126207691 4849345 222322..222795 1 NC_009053.1 phosphatidylglycerophosphatase A 222795 pgpA 4849345 pgpA Actinobacillus pleuropneumoniae serovar 5b str. L20 phosphatidylglycerophosphatase A YP_001052916.1 222322 D 416269 CDS YP_001052917.1 126207692 4849137 222804..223430 1 NC_009053.1 threonine efflux protein 223430 4849137 APL_0204 Actinobacillus pleuropneumoniae serovar 5b str. L20 threonine efflux protein YP_001052917.1 222804 D 416269 CDS YP_001052918.1 126207693 4848504 complement(223489..224526) 1 NC_009053.1 rRNA methyltransferase 224526 4848504 APL_0205 Actinobacillus pleuropneumoniae serovar 5b str. L20 rRNA methyltransferase YP_001052918.1 223489 R 416269 CDS YP_001052919.1 126207694 4850361 224692..225504 1 NC_009053.1 inositol-1-monophosphatase 225504 suhB 4850361 suhB Actinobacillus pleuropneumoniae serovar 5b str. L20 inositol-1-monophosphatase YP_001052919.1 224692 D 416269 CDS YP_001052920.1 126207695 4849947 225625..227478 1 NC_009053.1 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate; 1-deoxy-D-xylulose-5-phosphate synthase 227478 dxs 4849947 dxs Actinobacillus pleuropneumoniae serovar 5b str. L20 1-deoxy-D-xylulose-5-phosphate synthase YP_001052920.1 225625 D 416269 CDS YP_001052921.1 126207696 4849697 complement(227524..227862) 1 NC_009053.1 transposase-like protein 227862 4849697 APL_0208 Actinobacillus pleuropneumoniae serovar 5b str. L20 transposase-like protein YP_001052921.1 227524 R 416269 CDS YP_001052922.1 126207697 4849959 complement(227895..228212) 1 NC_009053.1 transposase-like protein 228212 4849959 APL_0209 Actinobacillus pleuropneumoniae serovar 5b str. L20 transposase-like protein YP_001052922.1 227895 R 416269 CDS YP_001052923.1 126207698 4848969 complement(228224..228733) 1 NC_009053.1 transposase and inactivated derivatives 228733 4848969 APL_0210 Actinobacillus pleuropneumoniae serovar 5b str. L20 transposase and inactivated derivatives YP_001052923.1 228224 R 416269 CDS YP_001052924.1 126207699 4849582 complement(228822..230087) 1 NC_009053.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase 230087 glyA 4849582 glyA Actinobacillus pleuropneumoniae serovar 5b str. L20 serine hydroxymethyltransferase YP_001052924.1 228822 R 416269 CDS YP_001052925.1 126207700 4848976 complement(230318..231205) 1 NC_009053.1 catalyzes the phosphorylation of NAD to NADP; inorganic polyphosphate/ATP-NAD kinase 231205 ppnK 4848976 ppnK Actinobacillus pleuropneumoniae serovar 5b str. L20 inorganic polyphosphate/ATP-NAD kinase YP_001052925.1 230318 R 416269 CDS YP_001052926.1 126207701 4850321 complement(231296..234643) 1 NC_009053.1 hypothetical protein 234643 4850321 APL_0213 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001052926.1 231296 R 416269 CDS YP_001052927.1 126207702 4850069 complement(234640..235596) 1 NC_009053.1 hypothetical protein 235596 4850069 APL_0214 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001052927.1 234640 R 416269 CDS YP_001052928.1 126207703 4849803 complement(237305..237874) 1 NC_009053.1 hypothetical protein 237874 4849803 APL_0215 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001052928.1 237305 R 416269 CDS YP_001052929.1 126207704 4848799 complement(237877..238872) 1 NC_009053.1 hypothetical protein 238872 4848799 APL_0216 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001052929.1 237877 R 416269 CDS YP_001052930.1 126207705 4849603 complement(238874..239833) 1 NC_009053.1 hypothetical protein 239833 4849603 APL_0217 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001052930.1 238874 R 416269 CDS YP_001052931.1 126207706 4849123 complement(239830..241179) 1 NC_009053.1 hypothetical protein 241179 4849123 APL_0218 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001052931.1 239830 R 416269 CDS YP_001052932.1 126207707 4850216 241585..243516 1 NC_009053.1 catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; threonyl-tRNA synthetase 243516 thrS 4850216 thrS Actinobacillus pleuropneumoniae serovar 5b str. L20 threonyl-tRNA synthetase YP_001052932.1 241585 D 416269 CDS YP_001052933.1 126207708 4848459 243658..244332 1 NC_009053.1 lipoprotein 244332 4848459 APL_0220 Actinobacillus pleuropneumoniae serovar 5b str. L20 lipoprotein YP_001052933.1 243658 D 416269 CDS YP_001052934.1 126207709 4849136 244342..244689 1 NC_009053.1 hypothetical protein 244689 4849136 APL_0221 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001052934.1 244342 D 416269 CDS YP_001052935.1 126207710 4848999 244701..245360 1 NC_009053.1 lipoprotein 245360 4848999 APL_0222 Actinobacillus pleuropneumoniae serovar 5b str. L20 lipoprotein YP_001052935.1 244701 D 416269 CDS YP_001052936.1 126207711 4849300 245638..246117 1 NC_009053.1 translation initiation factor IF-3 246117 infC 4849300 infC Actinobacillus pleuropneumoniae serovar 5b str. L20 translation initiation factor IF-3 YP_001052936.1 245638 D 416269 CDS YP_001052937.1 126207712 4848747 246366..246563 1 NC_009053.1 50S ribosomal protein L35 246563 rpmI 4848747 rpmI Actinobacillus pleuropneumoniae serovar 5b str. L20 50S ribosomal protein L35 YP_001052937.1 246366 D 416269 CDS YP_001052938.1 126207713 4849480 246631..246984 1 NC_009053.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit; 50S ribosomal protein L20 246984 rplT 4849480 rplT Actinobacillus pleuropneumoniae serovar 5b str. L20 50S ribosomal protein L20 YP_001052938.1 246631 D 416269 CDS YP_001052939.1 126207714 4849692 247033..247569 1 NC_009053.1 hypothetical protein 247569 4849692 APL_0226 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001052939.1 247033 D 416269 CDS YP_001052940.1 126207715 4849604 247602..247895 1 NC_009053.1 hypothetical protein 247895 4849604 APL_0227 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001052940.1 247602 D 416269 CDS YP_001052941.1 126207716 4850052 complement(247952..249247) 1 NC_009053.1 hypothetical protein 249247 4850052 APL_0228 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001052941.1 247952 R 416269 CDS YP_001052942.1 126207717 4848886 complement(249291..249941) 1 NC_009053.1 RNA pseudouridine synthase 249941 rluA 4848886 rluA Actinobacillus pleuropneumoniae serovar 5b str. L20 RNA pseudouridine synthase YP_001052942.1 249291 R 416269 CDS YP_001052943.1 126207718 4849578 249991..250623 1 NC_009053.1 phosphoglycerate mutase 250623 gpmB 4849578 gpmB Actinobacillus pleuropneumoniae serovar 5b str. L20 phosphoglycerate mutase YP_001052943.1 249991 D 416269 CDS YP_001052944.1 126207719 4849687 complement(250690..251103) 1 NC_009053.1 similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function; Holliday junction resolvase-like protein 251103 4849687 APL_0231 Actinobacillus pleuropneumoniae serovar 5b str. L20 Holliday junction resolvase-like protein YP_001052944.1 250690 R 416269 CDS YP_001052945.1 126207720 4849131 complement(251156..251716) 1 NC_009053.1 hypothetical protein 251716 4849131 APL_0232 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001052945.1 251156 R 416269 CDS YP_001052946.1 126207721 4849410 complement(251716..252447) 1 NC_009053.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase; 16S ribosomal RNA methyltransferase RsmE 252447 4849410 APL_0233 Actinobacillus pleuropneumoniae serovar 5b str. L20 16S ribosomal RNA methyltransferase RsmE YP_001052946.1 251716 R 416269 CDS YP_001052947.1 126207722 4848763 complement(252622..253212) 1 NC_009053.1 lipoprotein 253212 4848763 APL_0234 Actinobacillus pleuropneumoniae serovar 5b str. L20 lipoprotein YP_001052947.1 252622 R 416269 CDS YP_001052948.1 126207723 4849709 253341..253652 1 NC_009053.1 stress-induced morphogen 253652 bolA 4849709 bolA Actinobacillus pleuropneumoniae serovar 5b str. L20 stress-induced morphogen YP_001052948.1 253341 D 416269 CDS YP_001052949.1 126207724 4849291 complement(254045..254419) 1 NC_009053.1 lipoprotein 254419 4849291 APL_0236 Actinobacillus pleuropneumoniae serovar 5b str. L20 lipoprotein YP_001052949.1 254045 R 416269 CDS YP_001052950.1 126207725 4849938 complement(254439..254747) 1 NC_009053.1 hypothetical protein 254747 4849938 APL_0237 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001052950.1 254439 R 416269 CDS YP_001052951.1 126207726 4850328 254850..255176 1 NC_009053.1 hypothetical protein 255176 4850328 APL_0238 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001052951.1 254850 D 416269 CDS YP_001052952.1 126207727 4849668 255285..258002 1 NC_009053.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA 258002 secA 4849668 secA Actinobacillus pleuropneumoniae serovar 5b str. L20 preprotein translocase subunit SecA YP_001052952.1 255285 D 416269 CDS YP_001052953.1 126207728 4849575 258132..259319 1 NC_009053.1 hypothetical protein 259319 4849575 APL_0240 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001052953.1 258132 D 416269 CDS YP_001052954.1 126207729 4849832 259316..259714 1 NC_009053.1 mutator mutT protein 259714 mutT 4849832 mutT Actinobacillus pleuropneumoniae serovar 5b str. L20 mutator mutT protein YP_001052954.1 259316 D 416269 CDS YP_001052955.1 126207730 4849407 259949..260893 1 NC_009053.1 catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis; N-acetyl-gamma-glutamyl-phosphate reductase 260893 argC 4849407 argC Actinobacillus pleuropneumoniae serovar 5b str. L20 N-acetyl-gamma-glutamyl-phosphate reductase YP_001052955.1 259949 D 416269 CDS YP_001052956.1 126207731 4850320 260923..261777 1 NC_009053.1 catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate; acetylglutamate kinase 261777 argB 4850320 argB Actinobacillus pleuropneumoniae serovar 5b str. L20 acetylglutamate kinase YP_001052956.1 260923 D 416269 CDS YP_001052957.1 126207732 4849016 261791..262972 1 NC_009053.1 catalyzes the formation of N-acetyl-l-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine; acetylornithine aminotransferase 262972 argD 4849016 argD Actinobacillus pleuropneumoniae serovar 5b str. L20 acetylornithine aminotransferase YP_001052957.1 261791 D 416269 CDS YP_001052958.1 126207733 4850352 263186..264895 1 NC_009053.1 transferrin binding protein-like solute binding protein 264895 4850352 APL_0245 Actinobacillus pleuropneumoniae serovar 5b str. L20 transferrin binding protein-like solute binding protein YP_001052958.1 263186 D 416269 CDS YP_001052959.1 126207734 4850331 264910..267177 1 NC_009053.1 truncated transferrin-binding protein 1 267177 4850331 APL_0246 Actinobacillus pleuropneumoniae serovar 5b str. L20 truncated transferrin-binding protein 1 YP_001052959.1 264910 D 416269 CDS YP_001052960.1 126207735 4848841 complement(267745..269007) 1 NC_009053.1 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes; transcription termination factor Rho 269007 rho 4848841 rho Actinobacillus pleuropneumoniae serovar 5b str. L20 transcription termination factor Rho YP_001052960.1 267745 R 416269 CDS YP_001052961.1 126207736 4850357 complement(269205..270155) 1 NC_009053.1 cysteine synthase 270155 cysK 4850357 cysK Actinobacillus pleuropneumoniae serovar 5b str. L20 cysteine synthase YP_001052961.1 269205 R 416269 CDS YP_001052962.1 126207737 4848981 complement(270367..271317) 1 NC_009053.1 catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate; homoserine kinase 271317 thrB 4848981 thrB Actinobacillus pleuropneumoniae serovar 5b str. L20 homoserine kinase YP_001052962.1 270367 R 416269 CDS YP_001052963.1 126207738 4849975 complement(271317..273773) 1 NC_009053.1 multifunctional homotetrameric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways; bifunctional aspartokinase I/homoserine dehydrogenase I 273773 thrA 4849975 thrA Actinobacillus pleuropneumoniae serovar 5b str. L20 bifunctional aspartokinase I/homoserine dehydrogenase I YP_001052963.1 271317 R 416269 CDS YP_001052964.1 126207739 4849691 274183..274824 1 NC_009053.1 manganese superoxide dismutase 274824 sodA 4849691 sodA Actinobacillus pleuropneumoniae serovar 5b str. L20 manganese superoxide dismutase YP_001052964.1 274183 D 416269 CDS YP_001052965.1 126207740 4850055 complement(274912..276036) 1 NC_009053.1 converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer; alanine racemase 276036 alr 4850055 alr Actinobacillus pleuropneumoniae serovar 5b str. L20 alanine racemase YP_001052965.1 274912 R 416269 CDS YP_001052966.1 126207741 4850327 276157..278094 1 NC_009053.1 exodeoxyribonuclease V subunit alpha 278094 recD 4850327 recD Actinobacillus pleuropneumoniae serovar 5b str. L20 exodeoxyribonuclease V subunit alpha YP_001052966.1 276157 D 416269 CDS YP_001052967.1 126207742 4849124 complement(284242..285696) 1 NC_009053.1 aminoacyl-histidine dipeptidase 285696 pepD 4849124 pepD Actinobacillus pleuropneumoniae serovar 5b str. L20 aminoacyl-histidine dipeptidase YP_001052967.1 284242 R 416269 CDS YP_001052968.1 126207743 4848992 285869..286342 1 NC_009053.1 catalyzes the conversion of guanine, xanthine and, to a lesser extent, hypoxanthine to GMP, XMP and IMP, respectively; xanthine-guanine phosphoribosyltransferase 286342 gpt 4848992 gpt Actinobacillus pleuropneumoniae serovar 5b str. L20 xanthine-guanine phosphoribosyltransferase YP_001052968.1 285869 D 416269 CDS YP_001052969.1 126207744 4849492 286426..287046 1 NC_009053.1 Essential for recycling GMP and indirectly, cGMP; guanylate kinase 287046 gmk 4849492 gmk Actinobacillus pleuropneumoniae serovar 5b str. L20 guanylate kinase YP_001052969.1 286426 D 416269 CDS YP_001052970.1 126207745 4850131 287148..288542 1 NC_009053.1 outer membrane protein 288542 4850131 APL_0257 Actinobacillus pleuropneumoniae serovar 5b str. L20 outer membrane protein YP_001052970.1 287148 D 416269 CDS YP_001052971.1 126207746 4849411 complement(288590..288886) 1 NC_009053.1 hypothetical protein 288886 4849411 APL_0258 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001052971.1 288590 R 416269 CDS YP_001052972.1 126207747 4849024 complement(288879..289313) 1 NC_009053.1 oligoketide cyclase/lipid transport protein 289313 4849024 APL_0259 Actinobacillus pleuropneumoniae serovar 5b str. L20 oligoketide cyclase/lipid transport protein YP_001052972.1 288879 R 416269 CDS YP_001052973.1 126207748 4850463 complement(289361..290416) 1 NC_009053.1 Part of the ABC transporter complex modABC involved in molybdenum import; molybdate transporter ATP-binding protein 290416 modC 4850463 modC Actinobacillus pleuropneumoniae serovar 5b str. L20 molybdate transporter ATP-binding protein YP_001052973.1 289361 R 416269 CDS YP_001052974.1 126207749 4849595 complement(290420..291109) 1 NC_009053.1 part of ModCBA molybdate transporter; member of ABC superfamily; inner membrane component; regulated by repressor protein ModE; molybdate ABC transporter permease 291109 modB 4849595 modB Actinobacillus pleuropneumoniae serovar 5b str. L20 molybdate ABC transporter permease YP_001052974.1 290420 R 416269 CDS YP_001052975.1 126207750 4849834 complement(291169..291927) 1 NC_009053.1 molybdate-binding periplasmic protein 291927 modA 4849834 modA Actinobacillus pleuropneumoniae serovar 5b str. L20 molybdate-binding periplasmic protein YP_001052975.1 291169 R 416269 CDS YP_001052976.1 126207751 4850204 complement(292023..292784) 1 NC_009053.1 ABC transport system permease 292784 4850204 APL_0263 Actinobacillus pleuropneumoniae serovar 5b str. L20 ABC transport system permease YP_001052976.1 292023 R 416269 CDS YP_001052977.1 126207752 4850520 complement(292788..293696) 1 NC_009053.1 ABC transporter ATP-binding protein 293696 4850520 APL_0264 Actinobacillus pleuropneumoniae serovar 5b str. L20 ABC transporter ATP-binding protein YP_001052977.1 292788 R 416269 CDS YP_001052978.1 126207753 4848964 complement(293696..295762) 1 NC_009053.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA; DNA polymerase III subunits gamma and tau 295762 dnaX 4848964 dnaX Actinobacillus pleuropneumoniae serovar 5b str. L20 DNA polymerase III subunits gamma and tau YP_001052978.1 293696 R 416269 CDS YP_001052979.1 126207754 4850209 complement(295811..296350) 1 NC_009053.1 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis; adenine phosphoribosyltransferase 296350 apt 4850209 apt Actinobacillus pleuropneumoniae serovar 5b str. L20 adenine phosphoribosyltransferase YP_001052979.1 295811 R 416269 CDS YP_001052980.1 126207755 4850194 296551..297183 1 NC_009053.1 hypothetical protein 297183 4850194 APL_0267 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001052980.1 296551 D 416269 CDS YP_001052981.1 126207756 4850339 297183..297545 1 NC_009053.1 translation initiation inhibitor 297545 4850339 APL_0268 Actinobacillus pleuropneumoniae serovar 5b str. L20 translation initiation inhibitor YP_001052981.1 297183 D 416269 CDS YP_001052982.1 126207757 4850358 297556..298650 1 NC_009053.1 threonine synthase 298650 thrCA 4850358 thrCA Actinobacillus pleuropneumoniae serovar 5b str. L20 threonine synthase YP_001052982.1 297556 D 416269 CDS YP_001052983.1 126207758 4849299 298665..299156 1 NC_009053.1 hypothetical protein 299156 4849299 APL_0270 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001052983.1 298665 D 416269 CDS YP_001052984.1 126207759 4849295 complement(299267..300022) 1 NC_009053.1 chelated iron transport system ATP-binding protein 300022 4849295 APL_0271 Actinobacillus pleuropneumoniae serovar 5b str. L20 chelated iron transport system ATP-binding protein YP_001052984.1 299267 R 416269 CDS YP_001052985.1 126207760 4849179 complement(300024..300920) 1 NC_009053.1 iron (chelated) ABC transporter, periplasmic-binding protein 300920 yfeA 4849179 yfeA Actinobacillus pleuropneumoniae serovar 5b str. L20 iron (chelated) ABC transporter, periplasmic-binding protein YP_001052985.1 300024 R 416269 CDS YP_001052986.1 126207761 4849128 complement(300987..301322) 1 NC_009053.1 dissimilatory sulfite reductase 301322 4849128 APL_0273 Actinobacillus pleuropneumoniae serovar 5b str. L20 dissimilatory sulfite reductase YP_001052986.1 300987 R 416269 CDS YP_001052987.1 126207762 4849125 complement(301375..302040) 1 NC_009053.1 hypothetical protein 302040 4849125 APL_0274 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001052987.1 301375 R 416269 CDS YP_001052988.1 126207763 4849015 302222..302773 1 NC_009053.1 phosphatidylglycerophosphate synthase 302773 pgsA 4849015 pgsA Actinobacillus pleuropneumoniae serovar 5b str. L20 phosphatidylglycerophosphate synthase YP_001052988.1 302222 D 416269 CDS YP_001052989.1 126207764 4848963 302893..304863 1 NC_009053.1 iron-regulated outer membrane protein B 304863 frpB 4848963 frpB Actinobacillus pleuropneumoniae serovar 5b str. L20 iron-regulated outer membrane protein B YP_001052989.1 302893 D 416269 CDS YP_001052990.1 126207765 4848769 305016..306848 1 NC_009053.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision; excinuclease ABC subunit C 306848 uvrC 4848769 uvrC Actinobacillus pleuropneumoniae serovar 5b str. L20 excinuclease ABC subunit C YP_001052990.1 305016 D 416269 CDS YP_001052991.1 126207766 4848836 306917..307669 1 NC_009053.1 Mg-dependent deoxyribonuclease 307669 4848836 APL_0278 Actinobacillus pleuropneumoniae serovar 5b str. L20 Mg-dependent deoxyribonuclease YP_001052991.1 306917 D 416269 CDS YP_001052992.1 126207767 4848755 complement(307806..309824) 1 NC_009053.1 ATP-dependent DNA helicase 309824 rep 4848755 rep Actinobacillus pleuropneumoniae serovar 5b str. L20 ATP-dependent DNA helicase YP_001052992.1 307806 R 416269 CDS YP_001052993.1 126207768 4849576 310158..311273 1 NC_009053.1 functions together with PotBCD (A2BCD) in ATP-dependent polyamine transport; PotA is the membrane-associated ATPase; putrescine/spermidine ABC transporter ATPase 311273 potA 4849576 potA Actinobacillus pleuropneumoniae serovar 5b str. L20 putrescine/spermidine ABC transporter ATPase YP_001052993.1 310158 D 416269 CDS YP_001052994.1 126207769 4850013 311260..312126 1 NC_009053.1 can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotB is a membrane component; spermidine/putrescine ABC transporter membrane protein 312126 potB 4850013 potB Actinobacillus pleuropneumoniae serovar 5b str. L20 spermidine/putrescine ABC transporter membrane protein YP_001052994.1 311260 D 416269 CDS YP_001052995.1 126207770 4849700 312153..312893 1 NC_009053.1 can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotC is a membrane component; spermidine/putrescine ABC transporter membrane protein 312893 potC 4849700 potC Actinobacillus pleuropneumoniae serovar 5b str. L20 spermidine/putrescine ABC transporter membrane protein YP_001052995.1 312153 D 416269 CDS YP_001052996.1 126207771 4848753 313035..313640 1 NC_009053.1 plays an essential role in ATP-dependent branch migration of the Holliday junction; Holliday junction DNA helicase RuvA 313640 ruvA 4848753 ruvA Actinobacillus pleuropneumoniae serovar 5b str. L20 Holliday junction DNA helicase RuvA YP_001052996.1 313035 D 416269 CDS YP_001052997.1 126207772 4849172 313779..314663 1 NC_009053.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration; Holliday junction DNA helicase RuvB 314663 ruvB 4849172 ruvB Actinobacillus pleuropneumoniae serovar 5b str. L20 Holliday junction DNA helicase RuvB YP_001052997.1 313779 D 416269 CDS YP_001052998.1 126207773 4850312 complement(314720..315424) 1 NC_009053.1 Involved in ubiquinone biosynthesis; 3-demethylubiquinone-9 3-methyltransferase 315424 ubiG 4850312 ubiG Actinobacillus pleuropneumoniae serovar 5b str. L20 3-demethylubiquinone-9 3-methyltransferase YP_001052998.1 314720 R 416269 CDS YP_001052999.1 126207774 4848939 315604..318294 1 NC_009053.1 DNA gyrase subunit A 318294 gyrA 4848939 gyrA Actinobacillus pleuropneumoniae serovar 5b str. L20 DNA gyrase subunit A YP_001052999.1 315604 D 416269 CDS YP_001053000.1 126207775 4850251 319940..320260 1 NC_009053.1 hypothetical protein 320260 4850251 APL_0289 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053000.1 319940 D 416269 CDS YP_001053001.1 126207776 4848545 320427..321521 1 NC_009053.1 Type I restriction enzyme EcoR124II specificity protein 321521 4848545 APL_0290 Actinobacillus pleuropneumoniae serovar 5b str. L20 Type I restriction enzyme EcoR124II specificity protein YP_001053001.1 320427 D 416269 CDS YP_001053002.1 126207777 4848791 322648..325785 1 NC_009053.1 type I site-specific restriction-modification system, R (restriction) subunit 325785 4848791 APL_0293 Actinobacillus pleuropneumoniae serovar 5b str. L20 type I site-specific restriction-modification system, R (restriction) subunit YP_001053002.1 322648 D 416269 CDS YP_001053003.1 126207778 4849858 325804..327747 1 NC_009053.1 Uup; in Escherichia coli this cytoplasmic protein was shown to contain ATPase activity; mutations in this gene affect RecA-independent excision of transposons and affects Mu bacteriophage growth; ABC transporter ATPase 327747 uupA 4849858 uupA Actinobacillus pleuropneumoniae serovar 5b str. L20 ABC transporter ATPase YP_001053003.1 325804 D 416269 CDS YP_001053004.1 126207779 4850368 327747..328511 1 NC_009053.1 hypothetical protein 328511 4850368 APL_0295 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053004.1 327747 D 416269 CDS YP_001053005.1 126207780 4849367 complement(328590..328922) 1 NC_009053.1 hypothetical protein 328922 4849367 APL_0296 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053005.1 328590 R 416269 CDS YP_001053006.1 126207781 4848902 329378..330928 1 NC_009053.1 cytochrome oxidase subunit 1 330928 cydA 4848902 cydA Actinobacillus pleuropneumoniae serovar 5b str. L20 cytochrome oxidase subunit 1 YP_001053006.1 329378 D 416269 CDS YP_001053007.1 126207782 4849720 330942..332078 1 NC_009053.1 cytochrome oxidase subunit 2 332078 cydB 4849720 cydB Actinobacillus pleuropneumoniae serovar 5b str. L20 cytochrome oxidase subunit 2 YP_001053007.1 330942 D 416269 CDS YP_001053008.1 126207783 4848531 332646..333035 1 NC_009053.1 hypothetical protein 333035 4848531 APL_0299 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053008.1 332646 D 416269 CDS YP_001053009.1 126207784 4849739 333070..333750 1 NC_009053.1 colicin transport protein TolQ 333750 tolQ 4849739 tolQ Actinobacillus pleuropneumoniae serovar 5b str. L20 colicin transport protein TolQ YP_001053009.1 333070 D 416269 CDS YP_001053010.1 126207785 4849474 333829..334269 1 NC_009053.1 membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins; colicin uptake protein TolR 334269 tolR 4849474 tolR Actinobacillus pleuropneumoniae serovar 5b str. L20 colicin uptake protein TolR YP_001053010.1 333829 D 416269 CDS YP_001053011.1 126207786 4849712 334285..335580 1 NC_009053.1 cell envelope integrity inner membrane protein TolA 335580 tolA 4849712 tolA Actinobacillus pleuropneumoniae serovar 5b str. L20 cell envelope integrity inner membrane protein TolA YP_001053011.1 334285 D 416269 CDS YP_001053012.1 126207787 4848550 335598..336878 1 NC_009053.1 forms dimers; may be involved in cell envelope integrity; interacts with outer membrane proteins and with the C-terminal domain of inner membrane protein TolA; translocation protein TolB 336878 tolB 4848550 tolB Actinobacillus pleuropneumoniae serovar 5b str. L20 translocation protein TolB YP_001053012.1 335598 D 416269 CDS YP_001053013.1 126207788 4850080 336904..337374 1 NC_009053.1 pubmed:8763621; outer membrane protein PalA 337374 palA 4850080 palA Actinobacillus pleuropneumoniae serovar 5b str. L20 outer membrane protein PalA YP_001053013.1 336904 D 416269 CDS YP_001053014.1 126207789 4849003 337552..338358 1 NC_009053.1 hypothetical protein 338358 4849003 APL_0305 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053014.1 337552 D 416269 CDS YP_001053015.1 126207790 4848489 338438..339298 1 NC_009053.1 functions as a co-chaperone with DnaK; involved in regulation of colanic acid capsule; inner membrane protein; dimerized via transmembrane domain; J-like domain is cytoplasmic and can functionally substitute for DnaJ; stimulates synthesis of colanic acid mucoid capsule through the RcsB/C signal transduction system; Dna-J like membrane chaperone protein 339298 djlA 4848489 djlA Actinobacillus pleuropneumoniae serovar 5b str. L20 Dna-J like membrane chaperone protein YP_001053015.1 338438 D 416269 CDS YP_001053016.1 126207791 4850130 339383..340345 1 NC_009053.1 tRNA-dihydrouridine synthase C 340345 dusC 4850130 dusC Actinobacillus pleuropneumoniae serovar 5b str. L20 tRNA-dihydrouridine synthase C YP_001053016.1 339383 D 416269 CDS YP_001053017.1 126207792 4848500 340397..341443 1 NC_009053.1 hypothetical protein 341443 4848500 APL_0308 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053017.1 340397 D 416269 CDS YP_001053018.1 126207793 4849762 complement(341631..343547) 1 NC_009053.1 ABC transporter ATP-binding protein YheS 343547 yheS 4849762 yheS Actinobacillus pleuropneumoniae serovar 5b str. L20 ABC transporter ATP-binding protein YheS YP_001053018.1 341631 R 416269 CDS YP_001053019.1 126207794 4849782 344138..345379 1 NC_009053.1 molybdopterin biosynthesis protein MoeA 345379 moeA 4849782 moeA Actinobacillus pleuropneumoniae serovar 5b str. L20 molybdopterin biosynthesis protein MoeA YP_001053019.1 344138 D 416269 CDS YP_001053020.1 126207795 4849852 345389..346135 1 NC_009053.1 ATP-dependent adenylate transferase, transfers adenyl moiety to the MoeD subunit of molybdopterin synthase; molybdopterin biosynthesis protein MoeB 346135 moeB 4849852 moeB Actinobacillus pleuropneumoniae serovar 5b str. L20 molybdopterin biosynthesis protein MoeB YP_001053020.1 345389 D 416269 CDS YP_001053021.1 126207796 4849070 complement(346529..347857) 1 NC_009053.1 in Escherichia coli this enzyme catalyzes the SAM-dependent methylation of U1939 in the 23S ribomal RNA; binds an iron-sulfur cluster [4Fe-4S]; 23S rRNA 5-methyluridine methyltransferase 347857 rumA 4849070 rumA Actinobacillus pleuropneumoniae serovar 5b str. L20 23S rRNA 5-methyluridine methyltransferase YP_001053021.1 346529 R 416269 CDS YP_001053022.1 126207797 4848469 347915..349240 1 NC_009053.1 dGTPase family type 2 subfamily; presumably hydrolyzes dGTP to deoxyguanosine and triphosphate; deoxyguanosinetriphosphate triphosphohydrolase-like protein 349240 4848469 APL_0313 Actinobacillus pleuropneumoniae serovar 5b str. L20 deoxyguanosinetriphosphate triphosphohydrolase-like protein YP_001053022.1 347915 D 416269 CDS YP_001053023.1 126207798 4850089 349416..352325 1 NC_009053.1 transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA; ATP-dependent helicase HepA 352325 hepA 4850089 hepA Actinobacillus pleuropneumoniae serovar 5b str. L20 ATP-dependent helicase HepA YP_001053023.1 349416 D 416269 CDS YP_001053024.1 126207799 4849289 352395..353108 1 NC_009053.1 ribosomal large subunit pseudouridine synthase A 353108 rluA 4849289 rluA Actinobacillus pleuropneumoniae serovar 5b str. L20 ribosomal large subunit pseudouridine synthase A YP_001053024.1 352395 D 416269 CDS YP_001053025.1 126207800 4850174 complement(353304..353852) 1 NC_009053.1 N-acetyl-anhydromuranmyl-L-alanine amidase 353852 ampD 4850174 ampD Actinobacillus pleuropneumoniae serovar 5b str. L20 N-acetyl-anhydromuranmyl-L-alanine amidase YP_001053025.1 353304 R 416269 CDS YP_001053026.1 126207801 4849998 353973..354815 1 NC_009053.1 hypothetical protein 354815 yhiR 4849998 yhiR Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053026.1 353973 D 416269 CDS YP_001053027.1 126207802 4850389 354902..355543 1 NC_009053.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate; orotate phosphoribosyltransferase 355543 pyrE 4850389 pyrE Actinobacillus pleuropneumoniae serovar 5b str. L20 orotate phosphoribosyltransferase YP_001053027.1 354902 D 416269 CDS YP_001053028.1 126207803 4848467 355682..356770 1 NC_009053.1 hypothetical protein 356770 4848467 APL_0319 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053028.1 355682 D 416269 CDS YP_001053029.1 126207804 4849519 complement(356847..358037) 1 NC_009053.1 catalyzes the formation of L-homocysteine from cystathionine; cystathionine beta-lyase 358037 metC 4849519 metC Actinobacillus pleuropneumoniae serovar 5b str. L20 cystathionine beta-lyase YP_001053029.1 356847 R 416269 CDS YP_001053030.1 126207805 4849109 complement(358114..358653) 1 NC_009053.1 disulfide oxidoreductase; integral membrane protein; required for perioplasmic disulfide bond formation; oxidizes DsbA protein; disulfide bond formation protein B 358653 dsbB 4849109 dsbB Actinobacillus pleuropneumoniae serovar 5b str. L20 disulfide bond formation protein B YP_001053030.1 358114 R 416269 CDS YP_001053031.1 126207806 4849254 complement(358750..360291) 1 NC_009053.1 involved in regulation of intracellular pH under alkaline conditions; sodium/proton antiporter 360291 nhaB 4849254 nhaB Actinobacillus pleuropneumoniae serovar 5b str. L20 sodium/proton antiporter YP_001053031.1 358750 R 416269 CDS YP_001053032.1 126207807 4848492 360456..361184 1 NC_009053.1 Multifunctional regulator of fatty acid metabolism; fatty acid metabolism regulator 361184 fadR 4848492 fadR Actinobacillus pleuropneumoniae serovar 5b str. L20 fatty acid metabolism regulator YP_001053032.1 360456 D 416269 CDS YP_001053033.1 126207808 4849644 361193..362263 1 NC_009053.1 PhoH-like protein 362263 phoH 4849644 phoH Actinobacillus pleuropneumoniae serovar 5b str. L20 PhoH-like protein YP_001053033.1 361193 D 416269 CDS YP_001053034.1 126207809 4848486 complement(362302..363279) 1 NC_009053.1 hypothetical protein 363279 4848486 APL_0325 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053034.1 362302 R 416269 CDS YP_001053035.1 126207810 4849157 complement(363351..364256) 1 NC_009053.1 peptide chain release factor 2 364256 prfB 4849157 prfB Actinobacillus pleuropneumoniae serovar 5b str. L20 peptide chain release factor 2 YP_001053035.1 363351 R 416269 CDS YP_001053036.1 126207811 4850157 364716..365633 1 NC_009053.1 catalyzes the formation of selenophosphate from selenide and ATP; selenophosphate synthetase 365633 selD 4850157 selD Actinobacillus pleuropneumoniae serovar 5b str. L20 selenophosphate synthetase YP_001053036.1 364716 D 416269 CDS YP_001053037.1 126207812 4850060 365638..366093 1 NC_009053.1 MutT/NUDIX family NTP pyrophosphohydrolase 366093 mutT 4850060 mutT Actinobacillus pleuropneumoniae serovar 5b str. L20 MutT/NUDIX family NTP pyrophosphohydrolase YP_001053037.1 365638 D 416269 CDS YP_001053038.1 126207813 4848498 366103..367302 1 NC_009053.1 2-octaprenyl-6-methoxyphenol hydroxylase 367302 4848498 APL_0329 Actinobacillus pleuropneumoniae serovar 5b str. L20 2-octaprenyl-6-methoxyphenol hydroxylase YP_001053038.1 366103 D 416269 CDS YP_001053039.1 126207814 4850308 complement(367332..367808) 1 NC_009053.1 hypothetical protein 367808 4850308 APL_0330 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053039.1 367332 R 416269 CDS YP_001053040.1 126207815 4849654 complement(367865..368542) 1 NC_009053.1 lipoprotein 368542 hlp 4849654 hlp Actinobacillus pleuropneumoniae serovar 5b str. L20 lipoprotein YP_001053040.1 367865 R 416269 CDS YP_001053041.1 126207816 4850413 complement(368623..369102) 1 NC_009053.1 lipoprotein HlpB 369102 hlpB 4850413 hlpB Actinobacillus pleuropneumoniae serovar 5b str. L20 lipoprotein HlpB YP_001053041.1 368623 R 416269 CDS YP_001053042.1 126207817 4850274 complement(369238..370383) 1 NC_009053.1 monooxygenase family protein 370383 visC 4850274 visC Actinobacillus pleuropneumoniae serovar 5b str. L20 monooxygenase family protein YP_001053042.1 369238 R 416269 CDS YP_001053043.1 126207818 4849666 complement(370507..371367) 1 NC_009053.1 hypothetical protein 371367 4849666 APL_0334 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053043.1 370507 R 416269 CDS YP_001053044.1 126207819 4849772 complement(371386..371898) 1 NC_009053.1 PTS system, nitrogen regulatory IIA-like protein 371898 ptsN 4849772 ptsN Actinobacillus pleuropneumoniae serovar 5b str. L20 PTS system, nitrogen regulatory IIA-like protein YP_001053044.1 371386 R 416269 CDS YP_001053045.1 126207820 4849032 complement(371948..372673) 1 NC_009053.1 ABC transporter ATP-binding protein 372673 yhgB 4849032 yhgB Actinobacillus pleuropneumoniae serovar 5b str. L20 ABC transporter ATP-binding protein YP_001053045.1 371948 R 416269 CDS YP_001053046.1 126207821 4848608 complement(372683..373186) 1 NC_009053.1 hypothetical protein 373186 4848608 APL_0337 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053046.1 372683 R 416269 CDS YP_001053047.1 126207822 4848798 complement(373211..373807) 1 NC_009053.1 hypothetical protein 373807 4848798 APL_0338 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053047.1 373211 R 416269 CDS YP_001053048.1 126207823 4848495 complement(373967..376606) 1 NC_009053.1 catalyzes the formation of oxaloacetate from phosphoenolpyruvate; phosphoenolpyruvate carboxylase 376606 pepC 4848495 pepC Actinobacillus pleuropneumoniae serovar 5b str. L20 phosphoenolpyruvate carboxylase YP_001053048.1 373967 R 416269 CDS YP_001053049.1 126207824 4849749 complement(376821..377660) 1 NC_009053.1 hypothetical protein 377660 4849749 APL_0340 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053049.1 376821 R 416269 CDS YP_001053050.1 126207825 4848473 complement(377657..378106) 1 NC_009053.1 hypothetical protein 378106 4848473 APL_0341 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053050.1 377657 R 416269 CDS YP_001053051.1 126207826 4848493 complement(378173..378733) 1 NC_009053.1 hypothetical protein 378733 4848493 APL_0342 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053051.1 378173 R 416269 CDS YP_001053052.1 126207827 4848501 complement(378909..380570) 1 NC_009053.1 Includes: Fructose-specific phosphotransferase enzyme IIB component; Fructose permease IIC component; PTS system fructose-specific transporter subunit IIBC 380570 fruA 4848501 fruA Actinobacillus pleuropneumoniae serovar 5b str. L20 PTS system fructose-specific transporter subunit IIBC YP_001053052.1 378909 R 416269 CDS YP_001053053.1 126207828 4848472 complement(380652..381599) 1 NC_009053.1 converts fructose-1-phosphate and ATP to fructose-1,6-bisphosphate and ADP; highly specific for fructose-1-phopshate; similar to PfkB; forms homodimers; 1-phosphofructokinase 381599 fruK 4848472 fruK Actinobacillus pleuropneumoniae serovar 5b str. L20 1-phosphofructokinase YP_001053053.1 380652 R 416269 CDS YP_001053054.1 126207829 4848474 complement(381614..383122) 1 NC_009053.1 phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIA is phosphorylated by phospho-HP which then transfers the phosphoryl group to the IIB componentr; PTS system fructose-specific transporter subunit IIA/HPr protein 383122 fruB 4848474 fruB Actinobacillus pleuropneumoniae serovar 5b str. L20 PTS system fructose-specific transporter subunit IIA/HPr protein YP_001053054.1 381614 R 416269 CDS YP_001053055.1 126207830 4849471 383383..385716 1 NC_009053.1 catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain; glycogen branching protein 385716 glgB 4849471 glgB Actinobacillus pleuropneumoniae serovar 5b str. L20 glycogen branching protein YP_001053055.1 383383 D 416269 CDS YP_001053056.1 126207831 4848505 385723..387708 1 NC_009053.1 glycogen operon protein GlgX 387708 glgX 4848505 glgX Actinobacillus pleuropneumoniae serovar 5b str. L20 glycogen operon protein GlgX YP_001053056.1 385723 D 416269 CDS YP_001053057.1 126207832 4848510 387724..389040 1 NC_009053.1 catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate; glucose-1-phosphate adenylyltransferase 389040 glgC 4848510 glgC Actinobacillus pleuropneumoniae serovar 5b str. L20 glucose-1-phosphate adenylyltransferase YP_001053057.1 387724 D 416269 CDS YP_001053058.1 126207833 4849988 389143..390579 1 NC_009053.1 catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose; glycogen synthase 390579 glgA 4849988 glgA Actinobacillus pleuropneumoniae serovar 5b str. L20 glycogen synthase YP_001053058.1 389143 D 416269 CDS YP_001053059.1 126207834 4849041 390609..393113 1 NC_009053.1 glycogen phosphorylase 393113 glgP 4849041 glgP Actinobacillus pleuropneumoniae serovar 5b str. L20 glycogen phosphorylase YP_001053059.1 390609 D 416269 CDS YP_001053060.1 126207835 4849819 complement(393225..393641) 1 NC_009053.1 nucleoside diphosphate kinase 393641 ndk 4849819 ndk Actinobacillus pleuropneumoniae serovar 5b str. L20 nucleoside diphosphate kinase YP_001053060.1 393225 R 416269 CDS YP_001053061.1 126207836 4849066 complement(393700..395727) 1 NC_009053.1 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content; methionyl-tRNA synthetase 395727 metG 4849066 metG Actinobacillus pleuropneumoniae serovar 5b str. L20 methionyl-tRNA synthetase YP_001053061.1 393700 R 416269 CDS YP_001053062.1 126207837 4848940 395906..396868 1 NC_009053.1 catalyzes the dehydration of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid to form O-succinylbenzoate; O-succinylbenzoate synthase 396868 menC 4848940 menC Actinobacillus pleuropneumoniae serovar 5b str. L20 O-succinylbenzoate synthase YP_001053062.1 395906 D 416269 CDS YP_001053063.1 126207838 4850423 397182..397874 1 NC_009053.1 ribosomal small subunit pseudouridine synthase A 397874 rsuA 4850423 rsuA Actinobacillus pleuropneumoniae serovar 5b str. L20 ribosomal small subunit pseudouridine synthase A YP_001053063.1 397182 D 416269 CDS YP_001053064.1 126207839 4850102 397874..399070 1 NC_009053.1 Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance; bicyclomycin/multidrug efflux system protein 399070 proP 4850102 proP Actinobacillus pleuropneumoniae serovar 5b str. L20 bicyclomycin/multidrug efflux system protein YP_001053064.1 397874 D 416269 CDS YP_001053065.1 126207840 4850145 complement(399116..399502) 1 NC_009053.1 hypothetical protein 399502 4850145 APL_0356 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053065.1 399116 R 416269 CDS YP_001053066.1 126207841 4848684 complement(399573..400142) 1 NC_009053.1 hypothetical protein 400142 4848684 APL_0357 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053066.1 399573 R 416269 CDS YP_001053067.1 126207842 4849433 400200..401042 1 NC_009053.1 Assists in DNA repair by cleaving phosphodiester bonds at apurinic or apyrimidinic sties to produce new 5' ends that are base-free deoxyribose 5-phosphate residues; endonuclease IV 401042 nfo 4849433 nfo Actinobacillus pleuropneumoniae serovar 5b str. L20 endonuclease IV YP_001053067.1 400200 D 416269 CDS YP_001053068.1 126207843 4849434 401163..401759 1 NC_009053.1 lipoprotein 401759 nlpC 4849434 nlpC Actinobacillus pleuropneumoniae serovar 5b str. L20 lipoprotein YP_001053068.1 401163 D 416269 CDS YP_001053069.1 126207844 4849776 complement(401808..402263) 1 NC_009053.1 hypothetical protein 402263 impA 4849776 impA Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053069.1 401808 R 416269 CDS YP_001053070.1 126207845 4850301 complement(402489..402875) 1 NC_009053.1 stress-induced glycyl radical protein that can replace an oxidatively damaged pyruvate formate-lyase subunit; autonomous glycyl radical cofactor GrcA 402875 grcA 4850301 grcA Actinobacillus pleuropneumoniae serovar 5b str. L20 autonomous glycyl radical cofactor GrcA YP_001053070.1 402489 R 416269 CDS YP_001053071.1 126207846 4848615 403081..403758 1 NC_009053.1 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; uracil-DNA glycosylase 403758 ung 4848615 ung Actinobacillus pleuropneumoniae serovar 5b str. L20 uracil-DNA glycosylase YP_001053071.1 403081 D 416269 CDS YP_001053072.1 126207847 4849435 complement(403856..404728) 1 NC_009053.1 hypothetical protein 404728 4849435 APL_0363 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053072.1 403856 R 416269 CDS YP_001053073.1 126207848 4848488 complement(404823..407621) 1 NC_009053.1 serotype-specific antigen 1 407621 ssa1 4848488 ssa1 Actinobacillus pleuropneumoniae serovar 5b str. L20 serotype-specific antigen 1 YP_001053073.1 404823 R 416269 CDS YP_001053074.1 126207849 4848496 complement(407842..411741) 1 NC_009053.1 involved in the post-transcriptional processing of the daa operon mRNA, which encodes proteins involved in fimbrial biogenesis of an enteropathogenic E. coli strain; ATP-dependent RNA helicase HrpA 411741 hrpA 4848496 hrpA Actinobacillus pleuropneumoniae serovar 5b str. L20 ATP-dependent RNA helicase HrpA YP_001053074.1 407842 R 416269 CDS YP_001053075.1 126207850 4849063 complement(411911..412363) 1 NC_009053.1 hypothetical protein 412363 4849063 APL_0366 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053075.1 411911 R 416269 CDS YP_001053076.1 126207851 4849732 complement(412560..413156) 1 NC_009053.1 with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor; heat shock protein GrpE 413156 grpE 4849732 grpE Actinobacillus pleuropneumoniae serovar 5b str. L20 heat shock protein GrpE YP_001053076.1 412560 R 416269 CDS YP_001053077.1 126207852 4849538 413401..414483 1 NC_009053.1 spermidine/putrescine-binding periplasmic protein 1 414483 potD2 4849538 potD2 Actinobacillus pleuropneumoniae serovar 5b str. L20 spermidine/putrescine-binding periplasmic protein 1 YP_001053077.1 413401 D 416269 CDS YP_001053078.1 126207853 4849637 414627..416018 1 NC_009053.1 multidrug resistance protein NorM 416018 norM 4849637 norM Actinobacillus pleuropneumoniae serovar 5b str. L20 multidrug resistance protein NorM YP_001053078.1 414627 D 416269 CDS YP_001053079.1 126207854 4848610 416034..419642 1 NC_009053.1 exodeoxyribonuclease V subunit beta 419642 recB 4848610 recB Actinobacillus pleuropneumoniae serovar 5b str. L20 exodeoxyribonuclease V subunit beta YP_001053079.1 416034 D 416269 CDS YP_001053080.1 126207855 4848490 complement(419720..421231) 1 NC_009053.1 Transfers the fatty acyl group on membrane lipoproteins; apolipoprotein N-acyltransferase 421231 lnt 4848490 lnt Actinobacillus pleuropneumoniae serovar 5b str. L20 apolipoprotein N-acyltransferase YP_001053080.1 419720 R 416269 CDS YP_001053081.1 126207856 4849211 complement(421313..422206) 1 NC_009053.1 magnesium and cobalt efflux protein 422206 corC 4849211 corC Actinobacillus pleuropneumoniae serovar 5b str. L20 magnesium and cobalt efflux protein YP_001053081.1 421313 R 416269 CDS YP_001053082.1 126207857 4849734 422376..422978 1 NC_009053.1 hypothetical protein 422978 4849734 APL_0373 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053082.1 422376 D 416269 CDS YP_001053083.1 126207858 4849747 423214..423996 1 NC_009053.1 glycerol uptake facilitator protein 423996 glpF 4849747 glpF Actinobacillus pleuropneumoniae serovar 5b str. L20 glycerol uptake facilitator protein YP_001053083.1 423214 D 416269 CDS YP_001053084.1 126207859 4850540 424031..425542 1 NC_009053.1 Converts glycerol and ADP to glycerol-3-phosphate and ADP; glycerol kinase 425542 glpK 4850540 glpK Actinobacillus pleuropneumoniae serovar 5b str. L20 glycerol kinase YP_001053084.1 424031 D 416269 CDS YP_001053085.1 126207860 4849930 complement(425663..428071) 1 NC_009053.1 ATP-dependent protease La 428071 lon 4849930 lon Actinobacillus pleuropneumoniae serovar 5b str. L20 ATP-dependent protease La YP_001053085.1 425663 R 416269 CDS YP_001053086.1 126207861 4849214 complement(428217..429662) 1 NC_009053.1 glycerol-3-phosphate transporter 429662 glpT 4849214 glpT Actinobacillus pleuropneumoniae serovar 5b str. L20 glycerol-3-phosphate transporter YP_001053086.1 428217 R 416269 CDS YP_001053087.1 126207862 4849296 complement(429865..430953) 1 NC_009053.1 hydrolyzes deacylated phospholipids to glycerol 3-phosphate and the corresponding alcohols; periplasmic; glycerophosphodiester phosphodiesterase 430953 glpQ 4849296 glpQ Actinobacillus pleuropneumoniae serovar 5b str. L20 glycerophosphodiester phosphodiesterase YP_001053087.1 429865 R 416269 CDS YP_001053088.1 126207863 4848491 431205..432890 1 NC_009053.1 anaerobic, catalyzes the conversion of glycerol 3-phosphate to dihydroxyacetone using fumarate or nitrate as electron acceptor; sn-glycerol-3-phosphate dehydrogenase subunit A 432890 glpA 4848491 glpA Actinobacillus pleuropneumoniae serovar 5b str. L20 sn-glycerol-3-phosphate dehydrogenase subunit A YP_001053088.1 431205 D 416269 CDS YP_001053089.1 126207864 4849845 432880..434166 1 NC_009053.1 sn-glycerol-3-phosphate dehydrogenase (anaerobic); catalyzes the formation of dihydroxyacetone from glycerol 3-phosphate; part of GlpABC complex; presumably this subunit is responsible for membrane interactions and contains iron-sulfur clusters; anaerobic glycerol-3-phosphate dehydrogenase subunit B 434166 glpB 4849845 glpB Actinobacillus pleuropneumoniae serovar 5b str. L20 anaerobic glycerol-3-phosphate dehydrogenase subunit B YP_001053089.1 432880 D 416269 CDS YP_001053090.1 126207865 4849497 434163..435437 1 NC_009053.1 anaerobic; with GlpAB catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate; sn-glycerol-3-phosphate dehydrogenase subunit C 435437 glpC 4849497 glpC Actinobacillus pleuropneumoniae serovar 5b str. L20 sn-glycerol-3-phosphate dehydrogenase subunit C YP_001053090.1 434163 D 416269 CDS YP_001053091.1 126207866 4850371 435609..436841 1 NC_009053.1 pubmed:8522537; Includes: Diaminohydroxyphosphoribosylaminopyrimidine deaminase; 5-amino-6-(5-phosphoribosylamino)uracil reductase; riboflavin biosynthesis protein 436841 ribD 4850371 ribD Actinobacillus pleuropneumoniae serovar 5b str. L20 riboflavin biosynthesis protein YP_001053091.1 435609 D 416269 CDS YP_001053092.1 126207867 4850289 436964..437611 1 NC_009053.1 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine; riboflavin synthase subunit alpha 437611 ribE 4850289 ribE Actinobacillus pleuropneumoniae serovar 5b str. L20 riboflavin synthase subunit alpha YP_001053092.1 436964 D 416269 CDS YP_001053093.1 126207868 4850491 437672..438877 1 NC_009053.1 pubmed:8522537; Includes: GTP cyclohydrolase-2; 3,4-dihydroxy-2-butanone 4-phosphate synthase; riboflavin biosynthesis protein 438877 ribA 4850491 ribA Actinobacillus pleuropneumoniae serovar 5b str. L20 riboflavin biosynthesis protein YP_001053093.1 437672 D 416269 CDS YP_001053094.1 126207869 4850446 438988..439449 1 NC_009053.1 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not; 6,7-dimethyl-8-ribityllumazine synthase 439449 ribH 4850446 ribH Actinobacillus pleuropneumoniae serovar 5b str. L20 6,7-dimethyl-8-ribityllumazine synthase YP_001053094.1 438988 D 416269 CDS YP_001053095.1 126207870 4849984 complement(439538..440026) 1 NC_009053.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreB 440026 greB 4849984 greB Actinobacillus pleuropneumoniae serovar 5b str. L20 transcription elongation factor GreB YP_001053095.1 439538 R 416269 CDS YP_001053096.1 126207871 4848889 complement(440036..440971) 1 NC_009053.1 arabinose-5-phosphate isomerase 440971 kpsF 4848889 kpsF Actinobacillus pleuropneumoniae serovar 5b str. L20 arabinose-5-phosphate isomerase YP_001053096.1 440036 R 416269 CDS YP_001053097.1 126207872 4849640 complement(441099..442391) 1 NC_009053.1 catalyzes the removal of an N-terminal amino acid from a peptide or arylamide; aminopeptidase B 442391 pepB 4849640 pepB Actinobacillus pleuropneumoniae serovar 5b str. L20 aminopeptidase B YP_001053097.1 441099 R 416269 CDS YP_001053098.1 126207873 4849773 complement(442506..443321) 1 NC_009053.1 lipoprotein E 443321 ompP4 4849773 ompP4 Actinobacillus pleuropneumoniae serovar 5b str. L20 lipoprotein E YP_001053098.1 442506 R 416269 CDS YP_001053099.1 126207874 4850084 443494..444432 1 NC_009053.1 hypothetical protein 444432 4850084 APL_0390 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053099.1 443494 D 416269 CDS YP_001053100.1 126207875 4849198 complement(444512..445693) 1 NC_009053.1 macrolide-specific efflux protein 445693 macA 4849198 macA Actinobacillus pleuropneumoniae serovar 5b str. L20 macrolide-specific efflux protein YP_001053100.1 444512 R 416269 CDS YP_001053101.1 126207876 4848966 complement(445790..446605) 1 NC_009053.1 hypothetical protein 446605 4848966 APL_0392 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053101.1 445790 R 416269 CDS YP_001053102.1 126207877 4848680 447202..448743 1 NC_009053.1 catalyzes the formation of 2-isopropylmalate from acetyl-CoA and 2-oxoisovalerate in leucine biosynthesis; 2-isopropylmalate synthase 448743 leuA 4848680 leuA Actinobacillus pleuropneumoniae serovar 5b str. L20 2-isopropylmalate synthase YP_001053102.1 447202 D 416269 CDS YP_001053103.1 126207878 4850464 449086..449664 1 NC_009053.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response; RNA polymerase sigma factor RpoE 449664 rpoE 4850464 rpoE Actinobacillus pleuropneumoniae serovar 5b str. L20 RNA polymerase sigma factor RpoE YP_001053103.1 449086 D 416269 CDS YP_001053104.1 126207879 4849993 449684..450307 1 NC_009053.1 sigma-E factor negative regulatory protein 450307 rseA 4849993 rseA Actinobacillus pleuropneumoniae serovar 5b str. L20 sigma-E factor negative regulatory protein YP_001053104.1 449684 D 416269 CDS YP_001053105.1 126207880 4848823 450532..450960 1 NC_009053.1 sigma-E factor regulatory protein 450960 rseC 4848823 rseC Actinobacillus pleuropneumoniae serovar 5b str. L20 sigma-E factor regulatory protein YP_001053105.1 450532 D 416269 CDS YP_001053106.1 126207881 4849270 450972..452663 1 NC_009053.1 Activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase 452663 lcfA 4849270 lcfA Actinobacillus pleuropneumoniae serovar 5b str. L20 long-chain-fatty-acid--CoA ligase YP_001053106.1 450972 D 416269 CDS YP_001053107.1 126207882 4850045 452730..453356 1 NC_009053.1 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate; uracil phosphoribosyltransferase 453356 upp 4850045 upp Actinobacillus pleuropneumoniae serovar 5b str. L20 uracil phosphoribosyltransferase YP_001053107.1 452730 D 416269 CDS YP_001053108.1 126207883 4850436 complement(453463..454332) 1 NC_009053.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin; dimethyladenosine transferase 454332 ksgA 4850436 ksgA Actinobacillus pleuropneumoniae serovar 5b str. L20 dimethyladenosine transferase YP_001053108.1 453463 R 416269 CDS YP_001053109.1 126207884 4848708 complement(454398..455348) 1 NC_009053.1 peptidyl-prolyl cis-trans isomerase SurA 455348 surA 4848708 surA Actinobacillus pleuropneumoniae serovar 5b str. L20 peptidyl-prolyl cis-trans isomerase SurA YP_001053109.1 454398 R 416269 CDS YP_001053110.1 126207885 4849058 complement(455429..455968) 1 NC_009053.1 regulates pyrimidine biosynthesis by binding to the mRNA of the pyr genes, also has been shown to have uracil phosphoribosyltransferase activity; bifunctional pyrimidine regulatory protein PyrR/uracil phosphoribosyltransferase 455968 pyrR 4849058 pyrR Actinobacillus pleuropneumoniae serovar 5b str. L20 bifunctional pyrimidine regulatory protein PyrR/uracil phosphoribosyltransferase YP_001053110.1 455429 R 416269 CDS YP_001053111.1 126207886 4849548 complement(455984..457414) 1 NC_009053.1 catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate to form D,D-heptose-1,7-bisphosphate and catalyzes transfer of ADP to D-glycero-D-manno-heptose 1-phosphate forming ADP-D,D-heptose; bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase 457414 hldE 4849548 hldE Actinobacillus pleuropneumoniae serovar 5b str. L20 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase YP_001053111.1 455984 R 416269 CDS YP_001053112.1 126207887 4850385 complement(457528..459048) 1 NC_009053.1 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains; GTP-binding protein EngA 459048 engA 4850385 engA Actinobacillus pleuropneumoniae serovar 5b str. L20 GTP-binding protein EngA YP_001053112.1 457528 R 416269 CDS YP_001053113.1 126207888 4849853 complement(459206..460516) 1 NC_009053.1 catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins; glutamyl-tRNA reductase 460516 hemA 4849853 hemA Actinobacillus pleuropneumoniae serovar 5b str. L20 glutamyl-tRNA reductase YP_001053113.1 459206 R 416269 CDS YP_001053114.1 126207889 4850472 460794..463001 1 NC_009053.1 GTP pyrophosphokinase 463001 relA 4850472 relA Actinobacillus pleuropneumoniae serovar 5b str. L20 GTP pyrophosphokinase YP_001053114.1 460794 D 416269 CDS YP_001053115.1 126207890 4850032 463075..464265 1 NC_009053.1 catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate; 1-deoxy-D-xylulose 5-phosphate reductoisomerase 464265 dxr 4850032 dxr Actinobacillus pleuropneumoniae serovar 5b str. L20 1-deoxy-D-xylulose 5-phosphate reductoisomerase YP_001053115.1 463075 D 416269 CDS YP_001053116.1 126207891 4850034 complement(464325..465119) 1 NC_009053.1 catalyzes the addition of (R)-3-hydroxytetradecanoyl to the glucosamine disaccharide in lipid A biosynthesis; UDP-N-acetylglucosamine acyltransferase 465119 lpxA 4850034 lpxA Actinobacillus pleuropneumoniae serovar 5b str. L20 UDP-N-acetylglucosamine acyltransferase YP_001053116.1 464325 R 416269 CDS YP_001053117.1 126207892 4850532 complement(465147..465611) 1 NC_009053.1 in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP; (3R)-hydroxymyristoyl-ACP dehydratase 465611 fabZ 4850532 fabZ Actinobacillus pleuropneumoniae serovar 5b str. L20 (3R)-hydroxymyristoyl-ACP dehydratase YP_001053117.1 465147 R 416269 CDS YP_001053118.1 126207893 4850126 complement(465680..466705) 1 NC_009053.1 adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase 466705 lpxD 4850126 lpxD Actinobacillus pleuropneumoniae serovar 5b str. L20 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase YP_001053118.1 465680 R 416269 CDS YP_001053119.1 126207894 4850156 complement(466705..467511) 1 NC_009053.1 hypothetical protein 467511 4850156 APL_0410 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053119.1 466705 R 416269 CDS YP_001053120.1 126207895 4849236 complement(467627..470008) 1 NC_009053.1 protective surface antigen D15 470008 D15 4849236 D15 Actinobacillus pleuropneumoniae serovar 5b str. L20 protective surface antigen D15 YP_001053120.1 467627 R 416269 CDS YP_001053121.1 126207896 4849151 complement(470070..471383) 1 NC_009053.1 zinc metalloprotease 471383 ecfE 4849151 ecfE Actinobacillus pleuropneumoniae serovar 5b str. L20 zinc metalloprotease YP_001053121.1 470070 R 416269 CDS YP_001053122.1 126207897 4849555 complement(471390..472259) 1 NC_009053.1 phosphatidate cytidylyltransferase 472259 cdsA 4849555 cdsA Actinobacillus pleuropneumoniae serovar 5b str. L20 phosphatidate cytidylyltransferase YP_001053122.1 471390 R 416269 CDS YP_001053123.1 126207898 4850397 complement(472284..472997) 1 NC_009053.1 undecaprenyl pyrophosphate synthetase 472997 uppS 4850397 uppS Actinobacillus pleuropneumoniae serovar 5b str. L20 undecaprenyl pyrophosphate synthetase YP_001053123.1 472284 R 416269 CDS YP_001053124.1 126207899 4848668 complement(473169..473876) 1 NC_009053.1 hydroxyacylglutathione hydrolase 473876 gloB 4848668 gloB Actinobacillus pleuropneumoniae serovar 5b str. L20 hydroxyacylglutathione hydrolase YP_001053124.1 473169 R 416269 CDS YP_001053125.1 126207900 4850273 complement(473935..474852) 1 NC_009053.1 catalyzes the formation of N-acetyl-D-glucosamine-6-phosphate from N-acetyl-D-glucosamine; N-acetyl-D-glucosamine kinase 474852 4850273 APL_0416 Actinobacillus pleuropneumoniae serovar 5b str. L20 N-acetyl-D-glucosamine kinase YP_001053125.1 473935 R 416269 CDS YP_001053126.1 126207901 4849227 complement(474855..475559) 1 NC_009053.1 phosphatidylglycerophosphatase B 475559 pgpB 4849227 pgpB Actinobacillus pleuropneumoniae serovar 5b str. L20 phosphatidylglycerophosphatase B YP_001053126.1 474855 R 416269 CDS YP_001053127.1 126207902 4848847 complement(475651..476052) 1 NC_009053.1 hypothetical protein 476052 4848847 APL_0418 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053127.1 475651 R 416269 CDS YP_001053128.1 126207903 4848858 476090..476848 1 NC_009053.1 UDP-glucose--lipooligosaccharide glucosyltransferase 476848 lgtF 4848858 lgtF Actinobacillus pleuropneumoniae serovar 5b str. L20 UDP-glucose--lipooligosaccharide glucosyltransferase YP_001053128.1 476090 D 416269 CDS YP_001053129.1 126207904 4850322 complement(476952..477731) 1 NC_009053.1 penicillin-binding protein 7 477731 pbpG 4850322 pbpG Actinobacillus pleuropneumoniae serovar 5b str. L20 penicillin-binding protein 7 YP_001053129.1 476952 R 416269 CDS YP_001053130.1 126207905 4849880 complement(477815..478852) 1 NC_009053.1 heptosyltransferase 478852 waaQ 4849880 waaQ Actinobacillus pleuropneumoniae serovar 5b str. L20 heptosyltransferase YP_001053130.1 477815 R 416269 CDS YP_001053131.1 126207906 4849166 479096..480427 1 NC_009053.1 catalyzes the formation of arginosuccinate from citrulline and aspartate in arginine biosynthesis; argininosuccinate synthase 480427 argG 4849166 argG Actinobacillus pleuropneumoniae serovar 5b str. L20 argininosuccinate synthase YP_001053131.1 479096 D 416269 CDS YP_001053132.1 126207907 4849462 480549..481010 1 NC_009053.1 An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids; ribonuclease H 481010 rnhA 4849462 rnhA Actinobacillus pleuropneumoniae serovar 5b str. L20 ribonuclease H YP_001053132.1 480549 D 416269 CDS YP_001053133.1 126207908 4850387 481167..481670 1 NC_009053.1 colicin V production protein 481670 cvpA 4850387 cvpA Actinobacillus pleuropneumoniae serovar 5b str. L20 colicin V production protein YP_001053133.1 481167 D 416269 CDS YP_001053134.1 126207909 4849646 481684..483201 1 NC_009053.1 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway; amidophosphoribosyltransferase 483201 purF 4849646 purF Actinobacillus pleuropneumoniae serovar 5b str. L20 amidophosphoribosyltransferase YP_001053134.1 481684 D 416269 CDS YP_001053135.1 126207910 4849512 complement(483270..483728) 1 NC_009053.1 hypothetical protein 483728 4849512 APL_0426 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053135.1 483270 R 416269 CDS YP_001053136.1 126207911 4849507 complement(483824..485164) 1 NC_009053.1 converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer; glutamate dehydrogenase 485164 gdhA 4849507 gdhA Actinobacillus pleuropneumoniae serovar 5b str. L20 glutamate dehydrogenase YP_001053136.1 483824 R 416269 CDS YP_001053137.1 126207912 4849093 complement(485468..485812) 1 NC_009053.1 small protein A 485812 smpA 4849093 smpA Actinobacillus pleuropneumoniae serovar 5b str. L20 small protein A YP_001053137.1 485468 R 416269 CDS YP_001053138.1 126207913 4849616 complement(485883..486884) 1 NC_009053.1 nucleoid-associated protein NdpA 486884 4849616 APL_0429 Actinobacillus pleuropneumoniae serovar 5b str. L20 nucleoid-associated protein NdpA YP_001053138.1 485883 R 416269 CDS YP_001053139.1 126207914 4850275 486977..487366 1 NC_009053.1 hypothetical protein 487366 4850275 APL_0430 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053139.1 486977 D 416269 CDS YP_001053140.1 126207915 4848943 487394..488131 1 NC_009053.1 hypothetical protein 488131 4848943 APL_0431 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053140.1 487394 D 416269 CDS YP_001053141.1 126207916 4849836 488696..489778 1 NC_009053.1 catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis; 3-isopropylmalate dehydrogenase 489778 leuB 4849836 leuB Actinobacillus pleuropneumoniae serovar 5b str. L20 3-isopropylmalate dehydrogenase YP_001053141.1 488696 D 416269 CDS YP_001053142.1 126207917 4850240 complement(489902..490297) 1 NC_009053.1 this stereospecific enzymes reduces the R isomer of methionine sulfoxide while MsrA reduces the S form; provides protection against oxidative stress; methionine sulfoxide reductase B 490297 msrB 4850240 msrB Actinobacillus pleuropneumoniae serovar 5b str. L20 methionine sulfoxide reductase B YP_001053142.1 489902 R 416269 CDS YP_001053143.1 126207918 4849090 490520..491524 1 NC_009053.1 glyceraldehyde-3-phosphate dehydrogenase 491524 gapA 4849090 gapA Actinobacillus pleuropneumoniae serovar 5b str. L20 glyceraldehyde-3-phosphate dehydrogenase YP_001053143.1 490520 D 416269 CDS YP_001053144.1 126207919 4849029 491720..492772 1 NC_009053.1 functions in MreBCD complex in some organisms; rod shape-determining protein MreB 492772 mreB 4849029 mreB Actinobacillus pleuropneumoniae serovar 5b str. L20 rod shape-determining protein MreB YP_001053144.1 491720 D 416269 CDS YP_001053145.1 126207920 4849620 492889..493938 1 NC_009053.1 in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall; rod shape-determining protein MreC 493938 mreC 4849620 mreC Actinobacillus pleuropneumoniae serovar 5b str. L20 rod shape-determining protein MreC YP_001053145.1 492889 D 416269 CDS YP_001053146.1 126207921 4850011 493938..494426 1 NC_009053.1 rod shape-determining protein MreD 494426 mreD 4850011 mreD Actinobacillus pleuropneumoniae serovar 5b str. L20 rod shape-determining protein MreD YP_001053146.1 493938 D 416269 CDS YP_001053147.1 126207922 4849421 494439..495779 1 NC_009053.1 recombination factor protein RarA 495779 4849421 APL_0438 Actinobacillus pleuropneumoniae serovar 5b str. L20 recombination factor protein RarA YP_001053147.1 494439 D 416269 CDS YP_001053148.1 126207923 4850129 495860..496645 1 NC_009053.1 high-affinity zinc uptake system membrane protein ZnuB 496645 znuB 4850129 znuB Actinobacillus pleuropneumoniae serovar 5b str. L20 high-affinity zinc uptake system membrane protein ZnuB YP_001053148.1 495860 D 416269 CDS YP_001053149.1 126207924 4848890 496824..497621 1 NC_009053.1 hypothetical protein 497621 4848890 APL_0440 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053149.1 496824 D 416269 CDS YP_001053150.1 126207925 4848898 complement(497701..498777) 1 NC_009053.1 Catalyzes the conversion of acetyl-CoA and L-homoserine to CoA and O-acetyl-L-homoserine; homoserine O-acetyltransferase 498777 metX 4848898 metX Actinobacillus pleuropneumoniae serovar 5b str. L20 homoserine O-acetyltransferase YP_001053150.1 497701 R 416269 CDS YP_001053151.1 126207926 4848750 499069..499758 1 NC_009053.1 SanA protein 499758 sanA 4848750 sanA Actinobacillus pleuropneumoniae serovar 5b str. L20 SanA protein YP_001053151.1 499069 D 416269 CDS YP_001053152.1 126207927 4850478 500018..510061 1 NC_009053.1 autotransporter adhesin 510061 4850478 APL_0443 Actinobacillus pleuropneumoniae serovar 5b str. L20 autotransporter adhesin YP_001053152.1 500018 D 416269 CDS YP_001053153.1 126207928 4849113 complement(510370..511068) 1 NC_009053.1 hypothetical protein 511068 4849113 APL_0444 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053153.1 510370 R 416269 CDS YP_001053154.1 126207929 4849659 complement(511197..512606) 1 NC_009053.1 electron transport protein 512606 ykgF 4849659 ykgF Actinobacillus pleuropneumoniae serovar 5b str. L20 electron transport protein YP_001053154.1 511197 R 416269 CDS YP_001053155.1 126207930 4849509 complement(512616..513341) 1 NC_009053.1 dehydrogenase 513341 ykgE 4849509 ykgE Actinobacillus pleuropneumoniae serovar 5b str. L20 dehydrogenase YP_001053155.1 512616 R 416269 CDS YP_001053156.1 126207931 4848664 complement(513511..515106) 1 NC_009053.1 L-lactate permease 515106 lctP 4848664 lctP Actinobacillus pleuropneumoniae serovar 5b str. L20 L-lactate permease YP_001053156.1 513511 R 416269 CDS YP_001053157.1 126207932 4848588 complement(515572..515979) 1 NC_009053.1 DNA-binding protein H-NS 515979 hns 4848588 hns Actinobacillus pleuropneumoniae serovar 5b str. L20 DNA-binding protein H-NS YP_001053157.1 515572 R 416269 CDS YP_001053158.1 126207933 4850164 516537..518054 1 NC_009053.1 hypothetical protein 518054 4850164 APL_0449 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053158.1 516537 D 416269 CDS YP_001053159.1 126207934 4849395 518260..519231 1 NC_009053.1 D-galactose-binding periplasmic protein 519231 mglB 4849395 mglB Actinobacillus pleuropneumoniae serovar 5b str. L20 D-galactose-binding periplasmic protein YP_001053159.1 518260 D 416269 CDS YP_001053160.1 126207935 4849399 complement(519366..520238) 1 NC_009053.1 succinyl-CoA ligase [ADP-forming] subunit alpha 520238 sucD 4849399 sucD Actinobacillus pleuropneumoniae serovar 5b str. L20 succinyl-CoA ligase [ADP-forming] subunit alpha YP_001053160.1 519366 R 416269 CDS YP_001053161.1 126207936 4850531 complement(520241..521407) 1 NC_009053.1 catalyzes the interconversion of succinyl-CoA and succinate; succinyl-CoA synthetase subunit beta 521407 sucC 4850531 sucC Actinobacillus pleuropneumoniae serovar 5b str. L20 succinyl-CoA synthetase subunit beta YP_001053161.1 520241 R 416269 CDS YP_001053162.1 126207937 4850456 complement(521551..522417) 1 NC_009053.1 hypothetical protein 522417 4850456 APL_0453 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053162.1 521551 R 416269 CDS YP_001053163.1 126207938 4850079 complement(522560..523789) 1 NC_009053.1 dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex (E2) 523789 sucB 4850079 sucB Actinobacillus pleuropneumoniae serovar 5b str. L20 dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex (E2) YP_001053163.1 522560 R 416269 CDS YP_001053164.1 126207939 4849779 complement(523909..526719) 1 NC_009053.1 SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide; 2-oxoglutarate dehydrogenase E1 component 526719 sucA 4849779 sucA Actinobacillus pleuropneumoniae serovar 5b str. L20 2-oxoglutarate dehydrogenase E1 component YP_001053164.1 523909 R 416269 CDS YP_001053165.1 126207940 4849945 complement(526962..527762) 1 NC_009053.1 high-affinity zinc uptake system ATP-binding protein ZnuC 527762 znuC 4849945 znuC Actinobacillus pleuropneumoniae serovar 5b str. L20 high-affinity zinc uptake system ATP-binding protein ZnuC YP_001053165.1 526962 R 416269 CDS YP_001053166.1 126207941 4848513 527966..529456 1 NC_009053.1 metalloprotease 529456 4848513 APL_0457 Actinobacillus pleuropneumoniae serovar 5b str. L20 metalloprotease YP_001053166.1 527966 D 416269 CDS YP_001053167.1 126207942 4849817 529475..530170 1 NC_009053.1 thiol:disulfide interchange protein DsbC 530170 dsbC 4849817 dsbC Actinobacillus pleuropneumoniae serovar 5b str. L20 thiol:disulfide interchange protein DsbC YP_001053167.1 529475 D 416269 CDS YP_001053168.1 126207943 4848602 530220..531977 1 NC_009053.1 single-stranded-DNA-specific exonuclease RecJ 531977 recJ 4848602 recJ Actinobacillus pleuropneumoniae serovar 5b str. L20 single-stranded-DNA-specific exonuclease RecJ YP_001053168.1 530220 D 416269 CDS YP_001053169.1 126207944 4850167 532111..532962 1 NC_009053.1 lipoprotein Plp4 532962 plpD 4850167 plpD Actinobacillus pleuropneumoniae serovar 5b str. L20 lipoprotein Plp4 YP_001053169.1 532111 D 416269 CDS YP_001053170.1 126207945 4849088 533044..533862 1 NC_009053.1 HAD superfamily hydrolase 533862 4849088 APL_0461 Actinobacillus pleuropneumoniae serovar 5b str. L20 HAD superfamily hydrolase YP_001053170.1 533044 D 416269 CDS YP_001053171.1 126207946 4848480 533862..535577 1 NC_009053.1 nitrate/nitrite sensor protein NarQ 535577 narQ 4848480 narQ Actinobacillus pleuropneumoniae serovar 5b str. L20 nitrate/nitrite sensor protein NarQ YP_001053171.1 533862 D 416269 CDS YP_001053172.1 126207947 4849369 535600..536118 1 NC_009053.1 sortase 536118 4849369 APL_0463 Actinobacillus pleuropneumoniae serovar 5b str. L20 sortase YP_001053172.1 535600 D 416269 CDS YP_001053173.1 126207948 4849729 536159..536755 1 NC_009053.1 HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine; deoxyribonucleotide triphosphate pyrophosphatase 536755 4849729 APL_0464 Actinobacillus pleuropneumoniae serovar 5b str. L20 deoxyribonucleotide triphosphate pyrophosphatase YP_001053173.1 536159 D 416269 CDS YP_001053174.1 126207949 4848645 536783..537103 1 NC_009053.1 hypothetical protein 537103 4848645 APL_0465 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053174.1 536783 D 416269 CDS YP_001053175.1 126207950 4850530 complement(537209..538879) 1 NC_009053.1 catalyzes the formation of 10-formyltetrahydrofolate from formate and tetrahydrofolate; formate--tetrahydrofolate ligase 538879 fhs 4850530 fhs Actinobacillus pleuropneumoniae serovar 5b str. L20 formate--tetrahydrofolate ligase YP_001053175.1 537209 R 416269 CDS YP_001053176.1 126207951 4848516 538989..539435 1 NC_009053.1 hypothetical protein 539435 4848516 APL_0467 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053176.1 538989 D 416269 CDS YP_001053177.1 126207952 4850519 539525..540274 1 NC_009053.1 NADP-dependent dehydrogenase 540274 4850519 APL_0468 Actinobacillus pleuropneumoniae serovar 5b str. L20 NADP-dependent dehydrogenase YP_001053177.1 539525 D 416269 CDS YP_001053178.1 126207953 4849352 540457..541647 1 NC_009053.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate; tryptophan synthase subunit beta 541647 trpB 4849352 trpB Actinobacillus pleuropneumoniae serovar 5b str. L20 tryptophan synthase subunit beta YP_001053178.1 540457 D 416269 CDS YP_001053179.1 126207954 4849907 541649..542458 1 NC_009053.1 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis; tryptophan synthase subunit alpha 542458 trpA 4849907 trpA Actinobacillus pleuropneumoniae serovar 5b str. L20 tryptophan synthase subunit alpha YP_001053179.1 541649 D 416269 CDS YP_001053180.1 126207955 4849380 complement(542535..542828) 1 NC_009053.1 hypothetical protein 542828 4849380 APL_0471 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053180.1 542535 R 416269 CDS YP_001053181.1 126207956 4849257 complement(542837..543121) 1 NC_009053.1 hypothetical protein 543121 4849257 APL_0472 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053181.1 542837 R 416269 CDS YP_001053182.1 126207957 4849768 543301..546174 1 NC_009053.1 has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair; DNA polymerase I 546174 polA 4849768 polA Actinobacillus pleuropneumoniae serovar 5b str. L20 DNA polymerase I YP_001053182.1 543301 D 416269 CDS YP_001053183.1 126207958 4849737 546848..547489 1 NC_009053.1 participates with LolB in the incorporation of lipoprotein into the outer membrane; outer-membrane lipoprotein carrier protein 547489 lolA 4849737 lolA Actinobacillus pleuropneumoniae serovar 5b str. L20 outer-membrane lipoprotein carrier protein YP_001053183.1 546848 D 416269 CDS YP_001053184.1 126207959 4850243 547564..547872 1 NC_009053.1 When complexed with L-tryptophan it binds the operator region of the trp operon and prevents the initiation of transcription; Trp operon repressor 547872 trpR 4850243 trpR Actinobacillus pleuropneumoniae serovar 5b str. L20 Trp operon repressor YP_001053184.1 547564 D 416269 CDS YP_001053185.1 126207960 4849614 547901..548662 1 NC_009053.1 monofunctional biosynthetic peptidoglycan transglycosylase 548662 mtgA 4849614 mtgA Actinobacillus pleuropneumoniae serovar 5b str. L20 monofunctional biosynthetic peptidoglycan transglycosylase YP_001053185.1 547901 D 416269 CDS YP_001053186.1 126207961 4848694 complement(548732..549067) 1 NC_009053.1 hypothetical protein 549067 4848694 APL_0477 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053186.1 548732 R 416269 CDS YP_001053187.1 126207962 4850017 complement(549094..550098) 1 NC_009053.1 hypothetical protein 550098 4850017 APL_0478 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053187.1 549094 R 416269 CDS YP_001053188.1 126207963 4850042 complement(550113..550454) 1 NC_009053.1 hypothetical protein 550454 4850042 APL_0479 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053188.1 550113 R 416269 CDS YP_001053189.1 126207964 4850406 complement(550465..551808) 1 NC_009053.1 hypothetical protein 551808 4850406 APL_0480 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053189.1 550465 R 416269 CDS YP_001053190.1 126207965 4848914 complement(551853..552065) 1 NC_009053.1 hypothetical protein 552065 4848914 APL_0481 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053190.1 551853 R 416269 CDS YP_001053191.1 126207966 4848732 552220..552507 1 NC_009053.1 transcriptional regulator 552507 4848732 APL_0482 Actinobacillus pleuropneumoniae serovar 5b str. L20 transcriptional regulator YP_001053191.1 552220 D 416269 CDS YP_001053192.1 126207967 4849379 552582..553301 1 NC_009053.1 NADPH-dependent; oxygen-insensitive; catalyzes the reduction of nitroaromatic compounds; nitroreductase A 553301 4849379 APL_0483 Actinobacillus pleuropneumoniae serovar 5b str. L20 nitroreductase A YP_001053192.1 552582 D 416269 CDS YP_001053193.1 126207968 4849742 553298..554212 1 NC_009053.1 ribosomal protein S6 modification protein 554212 rimK 4849742 rimK Actinobacillus pleuropneumoniae serovar 5b str. L20 ribosomal protein S6 modification protein YP_001053193.1 553298 D 416269 CDS YP_001053194.1 126207969 4848515 complement(554247..555005) 1 NC_009053.1 hypothetical protein 555005 4848515 APL_0485 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053194.1 554247 R 416269 CDS YP_001053195.1 126207970 4849821 555322..556590 1 NC_009053.1 NADP-dependent malic enzyme (NADP-ME) 556590 maeB 4849821 maeB Actinobacillus pleuropneumoniae serovar 5b str. L20 NADP-dependent malic enzyme (NADP-ME) YP_001053195.1 555322 D 416269 CDS YP_001053196.1 126207971 4848481 556776..557063 1 NC_009053.1 the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response; 50S ribosomal protein L25 557063 rplY 4848481 rplY Actinobacillus pleuropneumoniae serovar 5b str. L20 50S ribosomal protein L25 YP_001053196.1 556776 D 416269 CDS YP_001053197.1 126207972 4849290 complement(557223..558263) 1 NC_009053.1 phage integrase family protein 558263 4849290 APL_0488 Actinobacillus pleuropneumoniae serovar 5b str. L20 phage integrase family protein YP_001053197.1 557223 R 416269 CDS YP_001053198.1 126207973 4849496 complement(558525..559046) 1 NC_009053.1 hypothetical protein 559046 4849496 APL_0489 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053198.1 558525 R 416269 CDS YP_001053199.1 126207974 4849941 complement(559253..559663) 1 NC_009053.1 hypothetical protein 559663 4849941 APL_0490 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053199.1 559253 R 416269 CDS YP_001053200.1 126207975 4849792 complement(559664..559897) 1 NC_009053.1 hypothetical protein 559897 4849792 APL_0491 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053200.1 559664 R 416269 CDS YP_001053201.1 126207976 4849944 complement(560157..560363) 1 NC_009053.1 hypothetical protein 560363 4849944 APL_0492 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053201.1 560157 R 416269 CDS YP_001053202.1 126207977 4849274 complement(560398..561120) 1 NC_009053.1 hypothetical protein 561120 4849274 APL_0493 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053202.1 560398 R 416269 CDS YP_001053203.1 126207978 4849138 complement(561319..562221) 1 NC_009053.1 Required for efficient pilin antigenic variation; recombination associated protein 562221 rdgC 4849138 rdgC Actinobacillus pleuropneumoniae serovar 5b str. L20 recombination associated protein YP_001053203.1 561319 R 416269 CDS YP_001053204.1 126207979 4848485 complement(565375..566190) 1 NC_009053.1 DNA-methyltransferase 566190 4848485 APL_0495 Actinobacillus pleuropneumoniae serovar 5b str. L20 DNA-methyltransferase YP_001053204.1 565375 R 416269 CDS YP_001053205.1 126207980 4849340 complement(566235..567878) 1 NC_009053.1 hypothetical protein 567878 4849340 APL_0496 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053205.1 566235 R 416269 CDS YP_001053206.1 126207981 4849731 complement(567934..568200) 1 NC_009053.1 hypothetical protein 568200 4849731 APL_0497 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053206.1 567934 R 416269 CDS YP_001053207.1 126207982 4849339 568720..568908 1 NC_009053.1 hypothetical protein 568908 4849339 APL_0498 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053207.1 568720 D 416269 CDS YP_001053208.1 126207983 4850383 568967..569662 1 NC_009053.1 hypothetical protein 569662 4850383 APL_0499 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053208.1 568967 D 416269 CDS YP_001053209.1 126207984 4849387 569818..570690 1 NC_009053.1 hypothetical protein 570690 4849387 APL_0500 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053209.1 569818 D 416269 CDS YP_001053210.1 126207985 4849217 570693..571217 1 NC_009053.1 DNA methylase 571217 4849217 APL_0501 Actinobacillus pleuropneumoniae serovar 5b str. L20 DNA methylase YP_001053210.1 570693 D 416269 CDS YP_001053211.1 126207986 4849972 571412..572434 1 NC_009053.1 hypothetical protein 572434 4849972 APL_0502 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053211.1 571412 D 416269 CDS YP_001053212.1 126207987 4850208 572506..572874 1 NC_009053.1 endodeoxyribonuclease RusA 572874 rusA 4850208 rusA Actinobacillus pleuropneumoniae serovar 5b str. L20 endodeoxyribonuclease RusA YP_001053212.1 572506 D 416269 CDS YP_001053213.1 126207988 4849116 572867..573379 1 NC_009053.1 hypothetical protein 573379 4849116 APL_0504 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053213.1 572867 D 416269 CDS YP_001053214.1 126207989 4850222 573751..574293 1 NC_009053.1 endolysin 574293 4850222 APL_0505 Actinobacillus pleuropneumoniae serovar 5b str. L20 endolysin YP_001053214.1 573751 D 416269 CDS YP_001053215.1 126207990 4849479 574385..574756 1 NC_009053.1 hypothetical protein 574756 4849479 APL_0506 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053215.1 574385 D 416269 CDS YP_001053216.1 126207991 4849243 575285..575704 1 NC_009053.1 hypothetical protein 575704 4849243 APL_0507 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053216.1 575285 D 416269 CDS YP_001053217.1 126207992 4849735 575707..577824 1 NC_009053.1 bacteriophage tail assembly protein 577824 4849735 APL_0508 Actinobacillus pleuropneumoniae serovar 5b str. L20 bacteriophage tail assembly protein YP_001053217.1 575707 D 416269 CDS YP_001053218.1 126207993 4849460 578045..579565 1 NC_009053.1 bacteriophage capsid protein 579565 4849460 APL_0509 Actinobacillus pleuropneumoniae serovar 5b str. L20 bacteriophage capsid protein YP_001053218.1 578045 D 416269 CDS YP_001053219.1 126207994 4849362 579501..581525 1 NC_009053.1 Clp-like protease 581525 4849362 APL_0510 Actinobacillus pleuropneumoniae serovar 5b str. L20 Clp-like protease YP_001053219.1 579501 D 416269 CDS YP_001053220.1 126207995 4849117 581599..581922 1 NC_009053.1 hypothetical protein 581922 4849117 APL_0511 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053220.1 581599 D 416269 CDS YP_001053221.1 126207996 4849284 581915..582217 1 NC_009053.1 hypothetical protein 582217 4849284 APL_0512 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053221.1 581915 D 416269 CDS YP_001053222.1 126207997 4849831 582220..582747 1 NC_009053.1 phage tail component 582747 4849831 APL_0513 Actinobacillus pleuropneumoniae serovar 5b str. L20 phage tail component YP_001053222.1 582220 D 416269 CDS YP_001053223.1 126207998 4848507 582744..583157 1 NC_009053.1 hypothetical protein 583157 4848507 APL_0514 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053223.1 582744 D 416269 CDS YP_001053224.1 126207999 4849332 583157..583813 1 NC_009053.1 hypothetical protein 583813 4849332 APL_0515 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053224.1 583157 D 416269 CDS YP_001053225.1 126208000 4850236 583872..584264 1 NC_009053.1 hypothetical protein 584264 4850236 APL_0516 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053225.1 583872 D 416269 CDS YP_001053226.1 126208001 4850181 584288..584563 1 NC_009053.1 hypothetical protein 584563 4850181 APL_0517 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053226.1 584288 D 416269 CDS YP_001053227.1 126208002 4850425 584929..588360 1 NC_009053.1 hypothetical protein 588360 4850425 APL_0518 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053227.1 584929 D 416269 CDS YP_001053228.1 126208003 4848522 588612..588947 1 NC_009053.1 phage minor tail protein 588947 4848522 APL_0519 Actinobacillus pleuropneumoniae serovar 5b str. L20 phage minor tail protein YP_001053228.1 588612 D 416269 CDS YP_001053229.1 126208004 4850026 589800..590663 1 NC_009053.1 hypothetical protein 590663 4850026 APL_0520 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053229.1 589800 D 416269 CDS YP_001053230.1 126208005 4849482 590784..591521 1 NC_009053.1 phage-related minor tail protein L 591521 4849482 APL_0521 Actinobacillus pleuropneumoniae serovar 5b str. L20 phage-related minor tail protein L YP_001053230.1 590784 D 416269 CDS YP_001053231.1 126208006 4849142 591682..592296 1 NC_009053.1 phage-related tail assembly protein K 592296 4849142 APL_0522 Actinobacillus pleuropneumoniae serovar 5b str. L20 phage-related tail assembly protein K YP_001053231.1 591682 D 416269 CDS YP_001053232.1 126208007 4848502 592320..592841 1 NC_009053.1 phage tail assembly protein 592841 4848502 APL_0523 Actinobacillus pleuropneumoniae serovar 5b str. L20 phage tail assembly protein YP_001053232.1 592320 D 416269 CDS YP_001053233.1 126208008 4848476 593159..598756 1 NC_009053.1 phage tail protein 598756 4848476 APL_0524 Actinobacillus pleuropneumoniae serovar 5b str. L20 phage tail protein YP_001053233.1 593159 D 416269 CDS YP_001053234.1 126208009 4848508 598815..599156 1 NC_009053.1 hypothetical protein 599156 4848508 APL_0525 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053234.1 598815 D 416269 CDS YP_001053235.1 126208010 4849960 600117..600758 1 NC_009053.1 hypothetical protein 600758 4849960 APL_0526 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053235.1 600117 D 416269 CDS YP_001053236.1 126208011 4848511 600881..601744 1 NC_009053.1 ABC transporter permease 601744 4848511 APL_0527 Actinobacillus pleuropneumoniae serovar 5b str. L20 ABC transporter permease YP_001053236.1 600881 D 416269 CDS YP_001053237.1 126208012 4849155 601844..603292 1 NC_009053.1 transporter 603292 4849155 APL_0528 Actinobacillus pleuropneumoniae serovar 5b str. L20 transporter YP_001053237.1 601844 D 416269 CDS YP_001053238.1 126208013 4850223 604407..605156 1 NC_009053.1 ABC transporter permease 605156 4850223 APL_0531 Actinobacillus pleuropneumoniae serovar 5b str. L20 ABC transporter permease YP_001053238.1 604407 D 416269 CDS YP_001053239.1 126208014 4849839 605200..605481 1 NC_009053.1 molybdopterin/thiamine biosynthesis dinucleotide-utilizing protein 605481 4849839 APL_0532 Actinobacillus pleuropneumoniae serovar 5b str. L20 molybdopterin/thiamine biosynthesis dinucleotide-utilizing protein YP_001053239.1 605200 D 416269 CDS YP_001053240.1 126208015 4848599 605569..605949 1 NC_009053.1 molybdopterin/thiamine biosynthesis dinucleotide-utilizing protein 605949 thiF 4848599 thiF Actinobacillus pleuropneumoniae serovar 5b str. L20 molybdopterin/thiamine biosynthesis dinucleotide-utilizing protein YP_001053240.1 605569 D 416269 CDS YP_001053241.1 126208016 4850128 605980..606180 1 NC_009053.1 thiamine biosynthesis protein ThiS 606180 thiS 4850128 thiS Actinobacillus pleuropneumoniae serovar 5b str. L20 thiamine biosynthesis protein ThiS YP_001053241.1 605980 D 416269 CDS YP_001053242.1 126208017 4850160 606616..607026 1 NC_009053.1 thiazole biosynthesis protein ThiG 607026 thiG 4850160 thiG Actinobacillus pleuropneumoniae serovar 5b str. L20 thiazole biosynthesis protein ThiG YP_001053242.1 606616 D 416269 CDS YP_001053243.1 126208018 4848553 607036..608181 1 NC_009053.1 thiazole biosynthesis protein ThiH 608181 thiH 4848553 thiH Actinobacillus pleuropneumoniae serovar 5b str. L20 thiazole biosynthesis protein ThiH YP_001053243.1 607036 D 416269 CDS YP_001053244.1 126208019 4848854 608236..608859 1 NC_009053.1 transcriptional activator 608859 4848854 APL_0537 Actinobacillus pleuropneumoniae serovar 5b str. L20 transcriptional activator YP_001053244.1 608236 D 416269 CDS YP_001053245.1 126208020 4848853 608882..609826 1 NC_009053.1 ABC transporter substrate-binding protein 609826 4848853 APL_0538 Actinobacillus pleuropneumoniae serovar 5b str. L20 ABC transporter substrate-binding protein YP_001053245.1 608882 D 416269 CDS YP_001053246.1 126208021 4849500 609992..610450 1 NC_009053.1 phosphomethylpyrimidine kinase 610450 thiD 4849500 thiD Actinobacillus pleuropneumoniae serovar 5b str. L20 phosphomethylpyrimidine kinase YP_001053246.1 609992 D 416269 CDS YP_001053247.1 126208022 4849688 610464..610877 1 NC_009053.1 thiamine monophosphate synthase 610877 thiE 4849688 thiE Actinobacillus pleuropneumoniae serovar 5b str. L20 thiamine monophosphate synthase YP_001053247.1 610464 D 416269 CDS YP_001053248.1 126208023 4849995 611049..612848 1 NC_009053.1 binds to the ribosome on the universally-conserved alpha-sarcin loop; GTP-binding protein LepA 612848 lepA 4849995 lepA Actinobacillus pleuropneumoniae serovar 5b str. L20 GTP-binding protein LepA YP_001053248.1 611049 D 416269 CDS YP_001053249.1 126208024 4849355 612953..613912 1 NC_009053.1 Signal peptidase I 613912 lepB 4849355 lepB Actinobacillus pleuropneumoniae serovar 5b str. L20 Signal peptidase I YP_001053249.1 612953 D 416269 CDS YP_001053250.1 126208025 4849615 614009..614680 1 NC_009053.1 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity; ribonuclease III 614680 rnc 4849615 rnc Actinobacillus pleuropneumoniae serovar 5b str. L20 ribonuclease III YP_001053250.1 614009 D 416269 CDS YP_001053251.1 126208026 4850396 614750..615664 1 NC_009053.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome; GTP-binding protein Era 615664 era 4850396 era Actinobacillus pleuropneumoniae serovar 5b str. L20 GTP-binding protein Era YP_001053251.1 614750 D 416269 CDS YP_001053252.1 126208027 4850408 615674..616396 1 NC_009053.1 involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA; DNA repair protein RecO 616396 recO 4850408 recO Actinobacillus pleuropneumoniae serovar 5b str. L20 DNA repair protein RecO YP_001053252.1 615674 D 416269 CDS YP_001053253.1 126208028 4849175 complement(616487..618049) 1 NC_009053.1 tight adherence protein G 618049 tadG 4849175 tadG Actinobacillus pleuropneumoniae serovar 5b str. L20 tight adherence protein G YP_001053253.1 616487 R 416269 CDS YP_001053254.1 126208029 4848562 complement(618073..618669) 1 NC_009053.1 tight adherence protein F 618669 tadF 4848562 tadF Actinobacillus pleuropneumoniae serovar 5b str. L20 tight adherence protein F YP_001053254.1 618073 R 416269 CDS YP_001053255.1 126208030 4849200 complement(618641..619126) 1 NC_009053.1 tight adherence protein E 619126 tadE 4849200 tadE Actinobacillus pleuropneumoniae serovar 5b str. L20 tight adherence protein E YP_001053255.1 618641 R 416269 CDS YP_001053256.1 126208031 4849202 complement(619129..619881) 1 NC_009053.1 tight adherence protein D 619881 tadD 4849202 tadD Actinobacillus pleuropneumoniae serovar 5b str. L20 tight adherence protein D YP_001053256.1 619129 R 416269 CDS YP_001053257.1 126208032 4850248 complement(619871..620716) 1 NC_009053.1 tight adherence protein C 620716 tadC 4850248 tadC Actinobacillus pleuropneumoniae serovar 5b str. L20 tight adherence protein C YP_001053257.1 619871 R 416269 CDS YP_001053258.1 126208033 4850182 complement(620716..621603) 1 NC_009053.1 tight adherence protein B 621603 tadB 4850182 tadB Actinobacillus pleuropneumoniae serovar 5b str. L20 tight adherence protein B YP_001053258.1 620716 R 416269 CDS YP_001053259.1 126208034 4850372 complement(621603..622880) 1 NC_009053.1 tight adherence protein A 622880 tadA 4850372 tadA Actinobacillus pleuropneumoniae serovar 5b str. L20 tight adherence protein A YP_001053259.1 621603 R 416269 CDS YP_001053260.1 126208035 4849780 complement(622889..624016) 1 NC_009053.1 flp operon protein D 624016 tadZ 4849780 tadZ Actinobacillus pleuropneumoniae serovar 5b str. L20 flp operon protein D YP_001053260.1 622889 R 416269 CDS YP_001053261.1 126208036 4850518 complement(624179..624682) 1 NC_009053.1 rough colony protein B 624682 rcpB 4850518 rcpB Actinobacillus pleuropneumoniae serovar 5b str. L20 rough colony protein B YP_001053261.1 624179 R 416269 CDS YP_001053262.1 126208037 4849021 complement(624679..626067) 1 NC_009053.1 rough colony protein A 626067 rcpA 4849021 rcpA Actinobacillus pleuropneumoniae serovar 5b str. L20 rough colony protein A YP_001053262.1 624679 R 416269 CDS YP_001053263.1 126208038 4848477 complement(626057..626875) 1 NC_009053.1 flp operon protein C 626875 rcpC 4848477 rcpC Actinobacillus pleuropneumoniae serovar 5b str. L20 flp operon protein C YP_001053263.1 626057 R 416269 CDS YP_001053264.1 126208039 4849976 complement(626904..627332) 1 NC_009053.1 flp operon protein B 627332 tadV 4849976 tadV Actinobacillus pleuropneumoniae serovar 5b str. L20 flp operon protein B YP_001053264.1 626904 R 416269 CDS YP_001053265.1 126208040 4849062 complement(627377..627568) 1 NC_009053.1 minor fimbrial protein 627568 flp2 4849062 flp2 Actinobacillus pleuropneumoniae serovar 5b str. L20 minor fimbrial protein YP_001053265.1 627377 R 416269 CDS YP_001053266.1 126208041 4849348 complement(627628..627858) 1 NC_009053.1 fimbrial protein Flp precursor 627858 flp1 4849348 flp1 Actinobacillus pleuropneumoniae serovar 5b str. L20 fimbrial protein Flp precursor YP_001053266.1 627628 R 416269 CDS YP_001053267.1 126208042 4849037 628451..629671 1 NC_009053.1 ATP-dependent RNA helicase RhlB 629671 rhlB 4849037 rhlB Actinobacillus pleuropneumoniae serovar 5b str. L20 ATP-dependent RNA helicase RhlB YP_001053267.1 628451 D 416269 CDS YP_001053268.1 126208043 4850237 629789..630211 1 NC_009053.1 hypothetical protein 630211 4850237 APL_0561 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053268.1 629789 D 416269 CDS YP_001053269.1 126208044 4848600 630262..631746 1 NC_009053.1 hypothetical protein 631746 4848600 APL_0562 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053269.1 630262 D 416269 CDS YP_001053270.1 126208045 4848663 631946..632977 1 NC_009053.1 Fe3+ ABC transporter substrate-binding protein 632977 afuA_2 4848663 afuA_2 Actinobacillus pleuropneumoniae serovar 5b str. L20 Fe3+ ABC transporter substrate-binding protein YP_001053270.1 631946 D 416269 CDS YP_001053271.1 126208046 4849067 633109..635109 1 NC_009053.1 ferric transport system permease protein 635109 afuB_2 4849067 afuB_2 Actinobacillus pleuropneumoniae serovar 5b str. L20 ferric transport system permease protein YP_001053271.1 633109 D 416269 CDS YP_001053272.1 126208047 4848927 635398..638538 1 NC_009053.1 ABC transporter ATP-binding protein 638538 cirA 4848927 cirA Actinobacillus pleuropneumoniae serovar 5b str. L20 ABC transporter ATP-binding protein YP_001053272.1 635398 D 416269 CDS YP_001053273.1 126208048 4848938 638803..639519 1 NC_009053.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit; 30S ribosomal protein S2 639519 rpsB 4848938 rpsB Actinobacillus pleuropneumoniae serovar 5b str. L20 30S ribosomal protein S2 YP_001053273.1 638803 D 416269 CDS YP_001053274.1 126208049 4848776 639615..640466 1 NC_009053.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu; elongation factor Ts 640466 tsf 4848776 tsf Actinobacillus pleuropneumoniae serovar 5b str. L20 elongation factor Ts YP_001053274.1 639615 D 416269 CDS YP_001053275.1 126208050 4850433 complement(640596..642149) 1 NC_009053.1 hypothetical protein 642149 4850433 APL_0568 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053275.1 640596 R 416269 CDS YP_001053276.1 126208051 4850270 642261..642974 1 NC_009053.1 Catalyzes the phosphorylation of UMP to UDP; uridylate kinase 642974 pyrH 4850270 pyrH Actinobacillus pleuropneumoniae serovar 5b str. L20 uridylate kinase YP_001053276.1 642261 D 416269 CDS YP_001053277.1 126208052 4850072 643158..643715 1 NC_009053.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs; ribosome recycling factor 643715 frr 4850072 frr Actinobacillus pleuropneumoniae serovar 5b str. L20 ribosome recycling factor YP_001053277.1 643158 D 416269 CDS YP_001053278.1 126208053 4849775 complement(643793..645193) 1 NC_009053.1 HTH-type transcriptional regulator 645193 gntR 4849775 gntR Actinobacillus pleuropneumoniae serovar 5b str. L20 HTH-type transcriptional regulator YP_001053278.1 643793 R 416269 CDS YP_001053279.1 126208054 4850439 645280..646167 1 NC_009053.1 with PdxT forms pyridoxal 5'-phosphate from glutamine, either ribose 5-phosphate or ribulose 5-phosphate, and either glyceraldehyde 3-phosphate or dihydroxyacetone phosphate; pyridoxal biosynthesis lyase PdxS 646167 pdxS 4850439 pdxS Actinobacillus pleuropneumoniae serovar 5b str. L20 pyridoxal biosynthesis lyase PdxS YP_001053279.1 645280 D 416269 CDS YP_001053280.1 126208055 4848573 646167..646742 1 NC_009053.1 with PdxST is involved in the biosynthesis of pyridoxal 5'-phosphate; PdxT catalyzes the hydrolysis of glutamine to glutamate and ammonia; PdxS utilizes the ammonia to synthesize pyridoxal 5'-phosphate; glutamine amidotransferase subunit PdxT 646742 pdxT 4848573 pdxT Actinobacillus pleuropneumoniae serovar 5b str. L20 glutamine amidotransferase subunit PdxT YP_001053280.1 646167 D 416269 CDS YP_001053281.1 126208056 4850221 complement(646816..647385) 1 NC_009053.1 tRNA-specific adenosine deaminase 647385 4850221 APL_0574 Actinobacillus pleuropneumoniae serovar 5b str. L20 tRNA-specific adenosine deaminase YP_001053281.1 646816 R 416269 CDS YP_001053282.1 126208057 4849259 complement(647423..649282) 1 NC_009053.1 cold-shock DEAD box protein A-like protein 649282 deaD 4849259 deaD Actinobacillus pleuropneumoniae serovar 5b str. L20 cold-shock DEAD box protein A-like protein YP_001053282.1 647423 R 416269 CDS YP_001053283.1 126208058 4848726 complement(649504..650445) 1 NC_009053.1 lipoprotein that appears to be involved in cell division; interacts with the periplasmic protease Prc and may be activated by protease processing; lipoprotein NlpI 650445 nlpI 4848726 nlpI Actinobacillus pleuropneumoniae serovar 5b str. L20 lipoprotein NlpI YP_001053283.1 649504 R 416269 CDS YP_001053284.1 126208059 4849054 complement(650506..652653) 1 NC_009053.1 polynucleotide phosphorylase/polyadenylase 652653 pnp 4849054 pnp Actinobacillus pleuropneumoniae serovar 5b str. L20 polynucleotide phosphorylase/polyadenylase YP_001053284.1 650506 R 416269 CDS YP_001053285.1 126208060 4848482 652954..655200 1 NC_009053.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit A 655200 parC 4848482 parC Actinobacillus pleuropneumoniae serovar 5b str. L20 DNA topoisomerase IV subunit A YP_001053285.1 652954 D 416269 CDS YP_001053286.1 126208061 4849076 655340..656671 1 NC_009053.1 acts with MukB and MukE to condense the chromosome and allow for segregation during cell division; condesin subunit F 656671 mukF 4849076 mukF Actinobacillus pleuropneumoniae serovar 5b str. L20 condesin subunit F YP_001053286.1 655340 D 416269 CDS YP_001053287.1 126208062 4849385 656751..657464 1 NC_009053.1 acts with MukB and MukF to condense the chromosome and allow for segregation during cell division; condesin subunit E 657464 mukE 4849385 mukE Actinobacillus pleuropneumoniae serovar 5b str. L20 condesin subunit E YP_001053287.1 656751 D 416269 CDS YP_001053288.1 126208063 4850470 657485..661975 1 NC_009053.1 SMC (structural maintenance of chromosomes) family of proteins; involved in chromosome condensatin and partitioning; forms a homodimer and the C-terminal is essential for DNA-binding activity while the purified N-terminal domain binds FtsZ; mutations result in cell division defects; cell division protein MukB 661975 mukB 4850470 mukB Actinobacillus pleuropneumoniae serovar 5b str. L20 cell division protein MukB YP_001053288.1 657485 D 416269 CDS YP_001053289.1 126208064 4849327 662052..663227 1 NC_009053.1 sugar efflux transporter 663227 sotB 4849327 sotB Actinobacillus pleuropneumoniae serovar 5b str. L20 sugar efflux transporter YP_001053289.1 662052 D 416269 CDS YP_001053290.1 126208065 4850228 complement(663279..665018) 1 NC_009053.1 hypothetical protein 665018 4850228 APL_0583 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053290.1 663279 R 416269 CDS YP_001053291.1 126208066 4850272 complement(665021..665242) 1 NC_009053.1 hypothetical protein 665242 4850272 APL_0584 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053291.1 665021 R 416269 CDS YP_001053292.1 126208067 4849650 665452..666030 1 NC_009053.1 hypothetical protein 666030 4849650 APL_0585 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053292.1 665452 D 416269 CDS YP_001053293.1 126208068 4850264 666063..667268 1 NC_009053.1 RND efflux membrane fusion protein 667268 4850264 APL_0586 Actinobacillus pleuropneumoniae serovar 5b str. L20 RND efflux membrane fusion protein YP_001053293.1 666063 D 416269 CDS YP_001053294.1 126208069 4850040 667281..670400 1 NC_009053.1 acriflavine resistance protein 670400 acrB 4850040 acrB Actinobacillus pleuropneumoniae serovar 5b str. L20 acriflavine resistance protein YP_001053294.1 667281 D 416269 CDS YP_001053295.1 126208070 4848525 670619..671992 1 NC_009053.1 forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis; bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 671992 glmU 4848525 glmU Actinobacillus pleuropneumoniae serovar 5b str. L20 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase YP_001053295.1 670619 D 416269 CDS YP_001053296.1 126208071 4849264 complement(672091..672408) 1 NC_009053.1 hypothetical protein 672408 4849264 APL_0589 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053296.1 672091 R 416269 CDS YP_001053297.1 126208072 4850535 complement(672412..673032) 1 NC_009053.1 hypothetical protein 673032 4850535 APL_0590 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053297.1 672412 R 416269 CDS YP_001053298.1 126208073 4848688 673326..674984 1 NC_009053.1 phosphoglucomutase/phosphomannomutase 674984 pgm 4848688 pgm Actinobacillus pleuropneumoniae serovar 5b str. L20 phosphoglucomutase/phosphomannomutase YP_001053298.1 673326 D 416269 CDS YP_001053299.1 126208074 4849920 complement(675066..676637) 1 NC_009053.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway; GMP synthase 676637 guaA 4849920 guaA Actinobacillus pleuropneumoniae serovar 5b str. L20 GMP synthase YP_001053299.1 675066 R 416269 CDS YP_001053300.1 126208075 4848725 complement(677056..678519) 1 NC_009053.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5'-monophosphate dehydrogenase 678519 guaB 4848725 guaB Actinobacillus pleuropneumoniae serovar 5b str. L20 inosine 5'-monophosphate dehydrogenase YP_001053300.1 677056 R 416269 CDS YP_001053301.1 126208076 4849193 678772..679398 1 NC_009053.1 Specifically methylates the uridine in position 2552 of 23S rRNA in the fully assembled 50S ribosomal subunit; 23S rRNA methyltransferase J 679398 rrmJ 4849193 rrmJ Actinobacillus pleuropneumoniae serovar 5b str. L20 23S rRNA methyltransferase J YP_001053301.1 678772 D 416269 CDS YP_001053302.1 126208077 4848857 679502..681424 1 NC_009053.1 cell division protease FtsH-like protein 681424 ftsH 4848857 ftsH Actinobacillus pleuropneumoniae serovar 5b str. L20 cell division protease FtsH-like protein YP_001053302.1 679502 D 416269 CDS YP_001053303.1 126208078 4849170 681662..682876 1 NC_009053.1 tyrosine-specific transporter 682876 tyrP-A 4849170 tyrP-A Actinobacillus pleuropneumoniae serovar 5b str. L20 tyrosine-specific transporter YP_001053303.1 681662 D 416269 CDS YP_001053304.1 126208079 4850138 682972..684189 1 NC_009053.1 tyrosine-specific transport protein 2 684189 tyrP-B 4850138 tyrP-B Actinobacillus pleuropneumoniae serovar 5b str. L20 tyrosine-specific transport protein 2 YP_001053304.1 682972 D 416269 CDS YP_001053305.1 126208080 4849164 684296..686848 1 NC_009053.1 PII uridylyl-transferase 686848 glnD 4849164 glnD Actinobacillus pleuropneumoniae serovar 5b str. L20 PII uridylyl-transferase YP_001053305.1 684296 D 416269 CDS YP_001053306.1 126208081 4848946 complement(686881..687279) 1 NC_009053.1 hypothetical protein 687279 4848946 APL_0599 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053306.1 686881 R 416269 CDS YP_001053307.1 126208082 4848534 687584..688012 1 NC_009053.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit; 50S ribosomal protein L13 688012 rplM 4848534 rplM Actinobacillus pleuropneumoniae serovar 5b str. L20 50S ribosomal protein L13 YP_001053307.1 687584 D 416269 CDS YP_001053308.1 126208083 4848734 688029..688424 1 NC_009053.1 forms a direct contact with the tRNA during translation; 30S ribosomal protein S9 688424 rpsI 4848734 rpsI Actinobacillus pleuropneumoniae serovar 5b str. L20 30S ribosomal protein S9 YP_001053308.1 688029 D 416269 CDS YP_001053309.1 126208084 4848765 688546..689328 1 NC_009053.1 hypothetical protein 689328 4848765 APL_0602 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053309.1 688546 D 416269 CDS YP_001053310.1 126208085 4849718 689328..689873 1 NC_009053.1 hypothetical protein 689873 4849718 APL_0603 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053310.1 689328 D 416269 CDS YP_001053311.1 126208086 4849335 689899..690822 1 NC_009053.1 cation-efflux pump FieF 690822 fieF 4849335 fieF Actinobacillus pleuropneumoniae serovar 5b str. L20 cation-efflux pump FieF YP_001053311.1 689899 D 416269 CDS YP_001053312.1 126208087 4850384 690803..691573 1 NC_009053.1 hypothetical protein 691573 4850384 APL_0605 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053312.1 690803 D 416269 CDS YP_001053313.1 126208088 4848957 691672..692997 1 NC_009053.1 symporter protein 692997 4848957 APL_0606 Actinobacillus pleuropneumoniae serovar 5b str. L20 symporter protein YP_001053313.1 691672 D 416269 CDS YP_001053314.1 126208089 4850503 complement(693099..693761) 1 NC_009053.1 NAD(P)H nitroreductase 693761 nfnB 4850503 nfnB Actinobacillus pleuropneumoniae serovar 5b str. L20 NAD(P)H nitroreductase YP_001053314.1 693099 R 416269 CDS YP_001053315.1 126208090 4850547 694038..695024 1 NC_009053.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily; phenylalanyl-tRNA synthetase subunit alpha 695024 pheS 4850547 pheS Actinobacillus pleuropneumoniae serovar 5b str. L20 phenylalanyl-tRNA synthetase subunit alpha YP_001053315.1 694038 D 416269 CDS YP_001053316.1 126208091 4850009 695123..697510 1 NC_009053.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily; phenylalanyl-tRNA synthetase subunit beta 697510 pheT 4850009 pheT Actinobacillus pleuropneumoniae serovar 5b str. L20 phenylalanyl-tRNA synthetase subunit beta YP_001053316.1 695123 D 416269 CDS YP_001053317.1 126208092 4848771 697528..697824 1 NC_009053.1 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control; integration host factor subunit alpha 697824 ihfA 4848771 ihfA Actinobacillus pleuropneumoniae serovar 5b str. L20 integration host factor subunit alpha YP_001053317.1 697528 D 416269 CDS YP_001053318.1 126208093 4849078 697885..698409 1 NC_009053.1 lipoprotein 698409 4849078 APL_0611 Actinobacillus pleuropneumoniae serovar 5b str. L20 lipoprotein YP_001053318.1 697885 D 416269 CDS YP_001053319.1 126208094 4849864 complement(698682..699464) 1 NC_009053.1 transposase 699464 4849864 APL_0612 Actinobacillus pleuropneumoniae serovar 5b str. L20 transposase YP_001053319.1 698682 R 416269 CDS YP_001053320.1 126208095 4850205 complement(699506..700015) 1 NC_009053.1 transposase 700015 4850205 APL_0613 Actinobacillus pleuropneumoniae serovar 5b str. L20 transposase YP_001053320.1 699506 R 416269 CDS YP_001053321.1 126208096 4849152 complement(700088..700807) 1 NC_009053.1 DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium; dithiobiotin synthetase 700807 bioD 4849152 bioD Actinobacillus pleuropneumoniae serovar 5b str. L20 dithiobiotin synthetase YP_001053321.1 700088 R 416269 CDS YP_001053322.1 126208097 4850158 complement(700861..702051) 1 NC_009053.1 transcriptional repressor of carbohydrate metabolism 702051 mlc 4850158 mlc Actinobacillus pleuropneumoniae serovar 5b str. L20 transcriptional repressor of carbohydrate metabolism YP_001053322.1 700861 R 416269 CDS YP_001053323.1 126208098 4849996 702230..703345 1 NC_009053.1 ribonuclease D 703345 rnd 4849996 rnd Actinobacillus pleuropneumoniae serovar 5b str. L20 ribonuclease D YP_001053323.1 702230 D 416269 CDS YP_001053324.1 126208099 4849728 703430..703912 1 NC_009053.1 mediates a global response to leucine; acts as a regulator for several genes involved in the high-affinity branched-chain amino acid transport system; leucine-responsive transcriptional regulator 703912 lrp 4849728 lrp Actinobacillus pleuropneumoniae serovar 5b str. L20 leucine-responsive transcriptional regulator YP_001053324.1 703430 D 416269 CDS YP_001053325.1 126208100 4849416 703924..706794 1 NC_009053.1 DNA translocase FtsK 706794 ftsK 4849416 ftsK Actinobacillus pleuropneumoniae serovar 5b str. L20 DNA translocase FtsK YP_001053325.1 703924 D 416269 CDS YP_001053326.1 126208101 4848928 706979..707842 1 NC_009053.1 hypothetical protein 707842 4848928 APL_0619 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053326.1 706979 D 416269 CDS YP_001053327.1 126208102 4850370 707965..709038 1 NC_009053.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase 709038 aroG 4850370 aroG Actinobacillus pleuropneumoniae serovar 5b str. L20 phospho-2-dehydro-3-deoxyheptonate aldolase YP_001053327.1 707965 D 416269 CDS YP_001053328.1 126208103 4849704 709142..709834 1 NC_009053.1 M22-like peptidase 709834 4849704 APL_0621 Actinobacillus pleuropneumoniae serovar 5b str. L20 M22-like peptidase YP_001053328.1 709142 D 416269 CDS YP_001053329.1 126208104 4850310 complement(710274..710855) 1 NC_009053.1 catalyzes the formation of thymidine 5'-phosphate from thymidine; thymidine kinase 710855 tdk 4850310 tdk Actinobacillus pleuropneumoniae serovar 5b str. L20 thymidine kinase YP_001053329.1 710274 R 416269 CDS YP_001053330.1 126208105 4849561 complement(710915..711133) 1 NC_009053.1 hypothetical protein 711133 4849561 APL_0623 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053330.1 710915 R 416269 CDS YP_001053331.1 126208106 4850452 711318..712316 1 NC_009053.1 type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese; fructose 1,6-bisphosphatase II 712316 glpX 4850452 glpX Actinobacillus pleuropneumoniae serovar 5b str. L20 fructose 1,6-bisphosphatase II YP_001053331.1 711318 D 416269 CDS YP_001053332.1 126208107 4849628 complement(712379..713152) 1 NC_009053.1 hypothetical protein 713152 4849628 APL_0625 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053332.1 712379 R 416269 CDS YP_001053333.1 126208108 4848569 complement(713244..715166) 1 NC_009053.1 macrolide-specific ABC-type efflux carrier 715166 macB 4848569 macB Actinobacillus pleuropneumoniae serovar 5b str. L20 macrolide-specific ABC-type efflux carrier YP_001053333.1 713244 R 416269 CDS YP_001053334.1 126208109 4850430 complement(715311..716195) 1 NC_009053.1 two-component sensor protein 716195 4850430 APL_0627 Actinobacillus pleuropneumoniae serovar 5b str. L20 two-component sensor protein YP_001053334.1 715311 R 416269 CDS YP_001053335.1 126208110 4850506 complement(716424..716711) 1 NC_009053.1 hypothetical protein 716711 4850506 APL_0628 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053335.1 716424 R 416269 CDS YP_001053336.1 126208111 4849870 complement(716776..717504) 1 NC_009053.1 transcriptional regulatory protein CpxR 717504 cpxR 4849870 cpxR Actinobacillus pleuropneumoniae serovar 5b str. L20 transcriptional regulatory protein CpxR YP_001053336.1 716776 R 416269 CDS YP_001053337.1 126208112 4849382 complement(717629..718228) 1 NC_009053.1 pyrophosphatase 718228 mazG 4849382 mazG Actinobacillus pleuropneumoniae serovar 5b str. L20 pyrophosphatase YP_001053337.1 717629 R 416269 CDS YP_001053338.1 126208113 4848891 718567..719460 1 NC_009053.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits; acetyl-CoA carboxylase subunit beta 719460 accD 4848891 accD Actinobacillus pleuropneumoniae serovar 5b str. L20 acetyl-CoA carboxylase subunit beta YP_001053338.1 718567 D 416269 CDS YP_001053339.1 126208114 4849235 719517..720821 1 NC_009053.1 bifunctional folylpolyglutamate synthase/dihydrofolate synthase 720821 folC 4849235 folC Actinobacillus pleuropneumoniae serovar 5b str. L20 bifunctional folylpolyglutamate synthase/dihydrofolate synthase YP_001053339.1 719517 D 416269 CDS YP_001053340.1 126208115 4849470 721030..722595 1 NC_009053.1 type I modification enzyme 722595 hsdM3 4849470 hsdM3 Actinobacillus pleuropneumoniae serovar 5b str. L20 type I modification enzyme YP_001053340.1 721030 D 416269 CDS YP_001053341.1 126208116 4848919 722739..723980 1 NC_009053.1 type I restriction system specificity protein 723980 hsdS3 4848919 hsdS3 Actinobacillus pleuropneumoniae serovar 5b str. L20 type I restriction system specificity protein YP_001053341.1 722739 D 416269 CDS YP_001053342.1 126208117 4850112 724156..724608 1 NC_009053.1 hypothetical protein 724608 4850112 APL_0635 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053342.1 724156 D 416269 CDS YP_001053343.1 126208118 4848782 724743..727883 1 NC_009053.1 type I site-specific restriction-modification system, restriction subunit 727883 hsdR3 4848782 hsdR3 Actinobacillus pleuropneumoniae serovar 5b str. L20 type I site-specific restriction-modification system, restriction subunit YP_001053343.1 724743 D 416269 CDS YP_001053344.1 126208119 4850438 728268..728729 1 NC_009053.1 in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins; hypothetical protein 728729 4850438 APL_0637 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053344.1 728268 D 416269 CDS YP_001053345.1 126208120 4849882 728746..730227 1 NC_009053.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination; transcription elongation factor NusA 730227 nusA 4849882 nusA Actinobacillus pleuropneumoniae serovar 5b str. L20 transcription elongation factor NusA YP_001053345.1 728746 D 416269 CDS YP_001053346.1 126208121 4850027 730249..732774 1 NC_009053.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; translation initiation factor IF-2 732774 infB 4850027 infB Actinobacillus pleuropneumoniae serovar 5b str. L20 translation initiation factor IF-2 YP_001053346.1 730249 D 416269 CDS YP_001053347.1 126208122 4850241 732946..733329 1 NC_009053.1 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock; ribosome-binding factor A 733329 rbfA 4850241 rbfA Actinobacillus pleuropneumoniae serovar 5b str. L20 ribosome-binding factor A YP_001053347.1 732946 D 416269 CDS YP_001053348.1 126208123 4848654 733330..734247 1 NC_009053.1 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs; tRNA pseudouridine synthase B 734247 truB 4848654 truB Actinobacillus pleuropneumoniae serovar 5b str. L20 tRNA pseudouridine synthase B YP_001053348.1 733330 D 416269 CDS YP_001053349.1 126208124 4848752 734293..735381 1 NC_009053.1 membrane-bound lytic murein transglycosylase B 735381 mltB 4848752 mltB Actinobacillus pleuropneumoniae serovar 5b str. L20 membrane-bound lytic murein transglycosylase B YP_001053349.1 734293 D 416269 CDS YP_001053350.1 126208125 4848605 735510..735695 1 NC_009053.1 hypothetical protein 735695 4848605 APL_0643 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053350.1 735510 D 416269 CDS YP_001053351.1 126208126 4849927 complement(735814..737952) 1 NC_009053.1 catalyzes the synthesis of acetylphosphate or propionylphosphate from acetyl-CoA or propionyl-CoA and inorganic phosphate; when using propionyl-CoA the enzyme is functioning in the anaerobic pathway catabolizing threonine to propionate; phosphate acetyltransferase 737952 pta 4849927 pta Actinobacillus pleuropneumoniae serovar 5b str. L20 phosphate acetyltransferase YP_001053351.1 735814 R 416269 CDS YP_001053352.1 126208127 4848842 complement(738008..739216) 1 NC_009053.1 AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA; acetate kinase 739216 ackA 4848842 ackA Actinobacillus pleuropneumoniae serovar 5b str. L20 acetate kinase YP_001053352.1 738008 R 416269 CDS YP_001053353.1 126208128 4848735 739513..741489 1 NC_009053.1 periplasmic enzyme; functions during ribonucleic acid degradation; 2',3'-cyclic nucleotides are first converted to 3'-nucleotide and then cleaved to yield a ribonucleotide and a phosphate; bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic protein 741489 cpdB 4848735 cpdB Actinobacillus pleuropneumoniae serovar 5b str. L20 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic protein YP_001053353.1 739513 D 416269 CDS YP_001053354.1 126208129 4849863 complement(742439..743515) 1 NC_009053.1 Outer membrane protein P2 precursor (OMP P2) 743515 ompP2 4849863 ompP2 Actinobacillus pleuropneumoniae serovar 5b str. L20 Outer membrane protein P2 precursor (OMP P2) YP_001053354.1 742439 R 416269 CDS YP_001053355.1 126208130 4849038 743985..744506 1 NC_009053.1 hypothetical protein 744506 4849038 APL_0650 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053355.1 743985 D 416269 CDS YP_001053356.1 126208131 4849515 complement(744538..745425) 1 NC_009053.1 UTP--glucose-1-phosphate uridylyltransferase 745425 galU 4849515 galU Actinobacillus pleuropneumoniae serovar 5b str. L20 UTP--glucose-1-phosphate uridylyltransferase YP_001053356.1 744538 R 416269 CDS YP_001053357.1 126208132 4849846 complement(745538..746896) 1 NC_009053.1 phosphomannomutase 746896 manB 4849846 manB Actinobacillus pleuropneumoniae serovar 5b str. L20 phosphomannomutase YP_001053357.1 745538 R 416269 CDS YP_001053358.1 126208133 4849837 complement(746931..747125) 1 NC_009053.1 affects carbohydrate metabolism; has regulatory role in many processes; carbon storage regulator 747125 csrA 4849837 csrA Actinobacillus pleuropneumoniae serovar 5b str. L20 carbon storage regulator YP_001053358.1 746931 R 416269 CDS YP_001053359.1 126208134 4849910 complement(747203..749827) 1 NC_009053.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; alanyl-tRNA synthetase 749827 alaS 4849910 alaS Actinobacillus pleuropneumoniae serovar 5b str. L20 alanyl-tRNA synthetase YP_001053359.1 747203 R 416269 CDS YP_001053360.1 126208135 4850314 complement(750053..750478) 1 NC_009053.1 universal stress protein A-like protein 750478 uspA 4850314 uspA Actinobacillus pleuropneumoniae serovar 5b str. L20 universal stress protein A-like protein YP_001053360.1 750053 R 416269 CDS YP_001053361.1 126208136 4850318 750742..751509 1 NC_009053.1 Global transcription factor that controls the expression of over 100 target genes in response to anoxia; fumarate/nitrate reduction transcriptional regulator 751509 hlyX 4850318 hlyX Actinobacillus pleuropneumoniae serovar 5b str. L20 fumarate/nitrate reduction transcriptional regulator YP_001053361.1 750742 D 416269 CDS YP_001053362.1 126208137 4849260 complement(751608..752024) 1 NC_009053.1 ClpXP protease specificity-enhancing factor 752024 sspB 4849260 sspB Actinobacillus pleuropneumoniae serovar 5b str. L20 ClpXP protease specificity-enhancing factor YP_001053362.1 751608 R 416269 CDS YP_001053363.1 126208138 4849760 complement(752024..752668) 1 NC_009053.1 stringent starvation protein A-like protein 752668 sspA 4849760 sspA Actinobacillus pleuropneumoniae serovar 5b str. L20 stringent starvation protein A-like protein YP_001053363.1 752024 R 416269 CDS YP_001053364.1 126208139 4849665 752887..753381 1 NC_009053.1 phosphoribosylaminoimidazole carboxylase catalytic subunit 753381 purE 4849665 purE Actinobacillus pleuropneumoniae serovar 5b str. L20 phosphoribosylaminoimidazole carboxylase catalytic subunit YP_001053364.1 752887 D 416269 CDS YP_001053365.1 126208140 4850050 753391..754356 1 NC_009053.1 L-asparaginase 754356 ansB 4850050 ansB Actinobacillus pleuropneumoniae serovar 5b str. L20 L-asparaginase YP_001053365.1 753391 D 416269 CDS YP_001053366.1 126208141 4850178 754466..755554 1 NC_009053.1 With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase ATPase subunit 755554 purK 4850178 purK Actinobacillus pleuropneumoniae serovar 5b str. L20 phosphoribosylaminoimidazole carboxylase ATPase subunit YP_001053366.1 754466 D 416269 CDS YP_001053367.1 126208142 4849663 755686..756882 1 NC_009053.1 catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate; aromatic amino acid aminotransferase 756882 aspC 4849663 aspC Actinobacillus pleuropneumoniae serovar 5b str. L20 aromatic amino acid aminotransferase YP_001053367.1 755686 D 416269 CDS YP_001053368.1 126208143 4850407 complement(757061..758347) 1 NC_009053.1 Xaa-Pro aminopeptidase 758347 pepP 4850407 pepP Actinobacillus pleuropneumoniae serovar 5b str. L20 Xaa-Pro aminopeptidase YP_001053368.1 757061 R 416269 CDS YP_001053369.1 126208144 4849866 complement(758756..759979) 1 NC_009053.1 hypothetical protein 759979 4849866 APL_0664 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053369.1 758756 R 416269 CDS YP_001053370.1 126208145 4849785 complement(760115..760504) 1 NC_009053.1 hypothetical protein 760504 4849785 APL_0665 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053370.1 760115 R 416269 CDS YP_001053371.1 126208146 4849419 complement(760505..760765) 1 NC_009053.1 hypothetical protein 760765 4849419 APL_0666 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053371.1 760505 R 416269 CDS YP_001053372.1 126208147 4849100 complement(760899..762920) 1 NC_009053.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion; excinuclease ABC subunit B 762920 uvrB 4849100 uvrB Actinobacillus pleuropneumoniae serovar 5b str. L20 excinuclease ABC subunit B YP_001053372.1 760899 R 416269 CDS YP_001053373.1 126208148 4849710 763097..763909 1 NC_009053.1 hypothetical protein 763909 4849710 APL_0668 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053373.1 763097 D 416269 CDS YP_001053374.1 126208149 4849234 763924..765114 1 NC_009053.1 iron dependent peroxidase 765114 4849234 APL_0669 Actinobacillus pleuropneumoniae serovar 5b str. L20 iron dependent peroxidase YP_001053374.1 763924 D 416269 CDS YP_001053375.1 126208150 4849632 765125..765745 1 NC_009053.1 Fe2+/Pb2+ permease 765745 4849632 APL_0670 Actinobacillus pleuropneumoniae serovar 5b str. L20 Fe2+/Pb2+ permease YP_001053375.1 765125 D 416269 CDS YP_001053376.1 126208151 4850309 complement(765785..766603) 1 NC_009053.1 TrpH-like protein 766603 trpH 4850309 trpH Actinobacillus pleuropneumoniae serovar 5b str. L20 TrpH-like protein YP_001053376.1 765785 R 416269 CDS YP_001053377.1 126208152 4848893 complement(766607..767197) 1 NC_009053.1 hypothetical protein 767197 4848893 APL_0672 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053377.1 766607 R 416269 CDS YP_001053378.1 126208153 4849733 complement(767214..768758) 1 NC_009053.1 Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates; exonuclease I 768758 sbcB 4849733 sbcB Actinobacillus pleuropneumoniae serovar 5b str. L20 exonuclease I YP_001053378.1 767214 R 416269 CDS YP_001053379.1 126208154 4850507 complement(769000..770406) 1 NC_009053.1 hypothetical protein 770406 4850507 APL_0674 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053379.1 769000 R 416269 CDS YP_001053380.1 126208155 4850404 770614..772017 1 NC_009053.1 catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; asparaginyl-tRNA synthetase 772017 asnC 4850404 asnC Actinobacillus pleuropneumoniae serovar 5b str. L20 asparaginyl-tRNA synthetase YP_001053380.1 770614 D 416269 CDS YP_001053381.1 126208156 4850486 complement(772121..773122) 1 NC_009053.1 hypothetical protein 773122 4850486 APL_0676 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053381.1 772121 R 416269 CDS YP_001053382.1 126208157 4849743 complement(773209..773772) 1 NC_009053.1 hypothetical protein 773772 4849743 APL_0677 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053382.1 773209 R 416269 CDS YP_001053383.1 126208158 4849216 773923..774489 1 NC_009053.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA; elongation factor P 774489 efp 4849216 efp Actinobacillus pleuropneumoniae serovar 5b str. L20 elongation factor P YP_001053383.1 773923 D 416269 CDS YP_001053384.1 126208159 4850177 774644..776314 1 NC_009053.1 catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; glutaminyl-tRNA synthetase 776314 glnS 4850177 glnS Actinobacillus pleuropneumoniae serovar 5b str. L20 glutaminyl-tRNA synthetase YP_001053384.1 774644 D 416269 CDS YP_001053385.1 126208160 4849818 complement(776545..777936) 1 NC_009053.1 transporter 777936 4849818 APL_0680 Actinobacillus pleuropneumoniae serovar 5b str. L20 transporter YP_001053385.1 776545 R 416269 CDS YP_001053386.1 126208161 4848758 complement(778118..780226) 1 NC_009053.1 soluble lytic murein transglycosylase 780226 4848758 APL_0681 Actinobacillus pleuropneumoniae serovar 5b str. L20 soluble lytic murein transglycosylase YP_001053386.1 778118 R 416269 CDS YP_001053387.1 126208162 4849400 complement(780335..780874) 1 NC_009053.1 yypoxanthine phosphoribosyltransferase 780874 hpt 4849400 hpt Actinobacillus pleuropneumoniae serovar 5b str. L20 yypoxanthine phosphoribosyltransferase YP_001053387.1 780335 R 416269 CDS YP_001053388.1 126208163 4850199 complement(780978..782114) 1 NC_009053.1 catalyzes the formation of cysteine from cystathionine; in B. subtilis also has O-acetylhomoserine thiolyase activity; cystathionine gamma-synthase 782114 metB 4850199 metB Actinobacillus pleuropneumoniae serovar 5b str. L20 cystathionine gamma-synthase YP_001053388.1 780978 R 416269 CDS YP_001053389.1 126208164 4849484 complement(782228..783037) 1 NC_009053.1 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate reductase 783037 dapB 4849484 dapB Actinobacillus pleuropneumoniae serovar 5b str. L20 dihydrodipicolinate reductase YP_001053389.1 782228 R 416269 CDS YP_001053390.1 126208165 4850086 complement(783146..784237) 1 NC_009053.1 RNA 2'-O-ribose methyltransferase 784237 mtfA 4850086 mtfA Actinobacillus pleuropneumoniae serovar 5b str. L20 RNA 2'-O-ribose methyltransferase YP_001053390.1 783146 R 416269 CDS YP_001053391.1 126208166 4850231 complement(784609..785013) 1 NC_009053.1 hypothetical protein 785013 4850231 APL_0686 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053391.1 784609 R 416269 CDS YP_001053392.1 126208167 4848915 785117..786808 1 NC_009053.1 component of the membrane-bound D-lactate oxidase, FAD-binding, NADH independent; D-lactate dehydrogenase 786808 dld 4848915 dld Actinobacillus pleuropneumoniae serovar 5b str. L20 D-lactate dehydrogenase YP_001053392.1 785117 D 416269 CDS YP_001053393.1 126208168 4849281 complement(786946..789420) 1 NC_009053.1 trimethylamine-N-oxide reductase precursor 789420 torZ 4849281 torZ Actinobacillus pleuropneumoniae serovar 5b str. L20 trimethylamine-N-oxide reductase precursor YP_001053393.1 786946 R 416269 CDS YP_001053394.1 126208169 4849696 complement(789616..790734) 1 NC_009053.1 cytochrome c-type protein TorY 790734 torY 4849696 torY Actinobacillus pleuropneumoniae serovar 5b str. L20 cytochrome c-type protein TorY YP_001053394.1 789616 R 416269 CDS YP_001053395.1 126208170 4848653 791084..792106 1 NC_009053.1 together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z; molybdenum cofactor biosynthesis protein A 792106 moaA 4848653 moaA Actinobacillus pleuropneumoniae serovar 5b str. L20 molybdenum cofactor biosynthesis protein A YP_001053395.1 791084 D 416269 CDS YP_001053396.1 126208171 4849808 792354..792830 1 NC_009053.1 molybdenum cofactor biosynthesis protein C 792830 moaC 4849808 moaC Actinobacillus pleuropneumoniae serovar 5b str. L20 molybdenum cofactor biosynthesis protein C YP_001053396.1 792354 D 416269 CDS YP_001053397.1 126208172 4849322 792852..793097 1 NC_009053.1 molybdopterin-converting factor subunit 1 793097 moaD 4849322 moaD Actinobacillus pleuropneumoniae serovar 5b str. L20 molybdopterin-converting factor subunit 1 YP_001053397.1 792852 D 416269 CDS YP_001053398.1 126208173 4850230 793098..793553 1 NC_009053.1 molybdopterin-converting factor subunit 2 793553 moaE 4850230 moaE Actinobacillus pleuropneumoniae serovar 5b str. L20 molybdopterin-converting factor subunit 2 YP_001053398.1 793098 D 416269 CDS YP_001053399.1 126208174 4849394 793634..794125 1 NC_009053.1 metalloprotease 794125 4849394 APL_0694 Actinobacillus pleuropneumoniae serovar 5b str. L20 metalloprotease YP_001053399.1 793634 D 416269 CDS YP_001053400.1 126208175 4849978 794137..795927 1 NC_009053.1 hypothetical protein 795927 4849978 APL_0695 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053400.1 794137 D 416269 CDS YP_001053401.1 126208176 4848978 complement(795991..798600) 1 NC_009053.1 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity; DNA topoisomerase I 798600 topA 4848978 topA Actinobacillus pleuropneumoniae serovar 5b str. L20 DNA topoisomerase I YP_001053401.1 795991 R 416269 CDS YP_001053402.1 126208177 4849703 798742..799638 1 NC_009053.1 HTH-type transcriptional regulator 799638 4849703 APL_0697 Actinobacillus pleuropneumoniae serovar 5b str. L20 HTH-type transcriptional regulator YP_001053402.1 798742 D 416269 CDS YP_001053403.1 126208178 4848575 complement(799732..801045) 1 NC_009053.1 catalyzes the formation of N-acetyl-L-glutamate from L-glutamate and acetyl-CoA in arginine biosynthesis; N-acetylglutamate synthase 801045 argA 4848575 argA Actinobacillus pleuropneumoniae serovar 5b str. L20 N-acetylglutamate synthase YP_001053403.1 799732 R 416269 CDS YP_001053404.1 126208179 4848647 complement(801193..802491) 1 NC_009053.1 catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis; 3-phosphoshikimate 1-carboxyvinyltransferase 802491 aroA 4848647 aroA Actinobacillus pleuropneumoniae serovar 5b str. L20 3-phosphoshikimate 1-carboxyvinyltransferase YP_001053404.1 801193 R 416269 CDS YP_001053405.1 126208180 4849807 complement(802505..803599) 1 NC_009053.1 catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis; histidinol-phosphate aminotransferase 803599 hisC 4849807 hisC Actinobacillus pleuropneumoniae serovar 5b str. L20 histidinol-phosphate aminotransferase YP_001053405.1 802505 R 416269 CDS YP_001053406.1 126208181 4849265 complement(803799..805067) 1 NC_009053.1 O-acetylhomoserine (thiol)-lyase 805067 4849265 APL_0701 Actinobacillus pleuropneumoniae serovar 5b str. L20 O-acetylhomoserine (thiol)-lyase YP_001053406.1 803799 R 416269 CDS YP_001053407.1 126208182 4848737 complement(805273..806361) 1 NC_009053.1 catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; required both in major phosphorylated pathway of serine biosynthesis and in the biosynthesis of pyridoxine; phosphoserine aminotransferase 806361 serC 4848737 serC Actinobacillus pleuropneumoniae serovar 5b str. L20 phosphoserine aminotransferase YP_001053407.1 805273 R 416269 CDS YP_001053408.1 126208183 4850296 complement(806555..809425) 1 NC_009053.1 ATP-dependent helicase 809425 4850296 APL_0703 Actinobacillus pleuropneumoniae serovar 5b str. L20 ATP-dependent helicase YP_001053408.1 806555 R 416269 CDS YP_001053409.1 126208184 4849186 complement(809425..812742) 1 NC_009053.1 hypothetical protein 812742 4849186 APL_0704 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053409.1 809425 R 416269 CDS YP_001053410.1 126208185 4849014 complement(813144..816032) 1 NC_009053.1 methylation subunit, type III restriction-modification system 816032 4849014 APL_0705 Actinobacillus pleuropneumoniae serovar 5b str. L20 methylation subunit, type III restriction-modification system YP_001053410.1 813144 R 416269 CDS YP_001053411.1 126208186 4849799 complement(816312..817184) 1 NC_009053.1 HTH-type transcriptional regulator 817184 4849799 APL_0706 Actinobacillus pleuropneumoniae serovar 5b str. L20 HTH-type transcriptional regulator YP_001053411.1 816312 R 416269 CDS YP_001053412.1 126208187 4850560 complement(817194..817661) 1 NC_009053.1 hypothetical protein 817661 4850560 APL_0707 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053412.1 817194 R 416269 CDS YP_001053413.1 126208188 4850477 complement(817862..819370) 1 NC_009053.1 exopolyphosphatase 819370 ppx 4850477 ppx Actinobacillus pleuropneumoniae serovar 5b str. L20 exopolyphosphatase YP_001053413.1 817862 R 416269 CDS YP_001053414.1 126208189 4849813 819579..819914 1 NC_009053.1 hypothetical protein 819914 4849813 APL_0709 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053414.1 819579 D 416269 CDS YP_001053415.1 126208190 4848679 820409..821761 1 NC_009053.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; functions in amino acid biosynthesis; lysine sensitive; aspartate kinase III 821761 lysC 4848679 lysC Actinobacillus pleuropneumoniae serovar 5b str. L20 aspartate kinase III YP_001053415.1 820409 D 416269 CDS YP_001053416.1 126208191 4849670 complement(821887..822336) 1 NC_009053.1 transcriptional regulator NrdR 822336 nrdR 4849670 nrdR Actinobacillus pleuropneumoniae serovar 5b str. L20 transcriptional regulator NrdR YP_001053416.1 821887 R 416269 CDS YP_001053417.1 126208192 4849856 complement(822336..822575) 1 NC_009053.1 hypothetical protein 822575 4849856 APL_0712 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053417.1 822336 R 416269 CDS YP_001053418.1 126208193 4849493 complement(822613..824076) 1 NC_009053.1 replicative DNA helicase 824076 dnaB 4849493 dnaB Actinobacillus pleuropneumoniae serovar 5b str. L20 replicative DNA helicase YP_001053418.1 822613 R 416269 CDS YP_001053419.1 126208194 4849876 824256..825164 1 NC_009053.1 ABC transport system periplasmic protein 825164 4849876 APL_0714 Actinobacillus pleuropneumoniae serovar 5b str. L20 ABC transport system periplasmic protein YP_001053419.1 824256 D 416269 CDS YP_001053420.1 126208195 4850229 825251..826198 1 NC_009053.1 ABC transporter permease 826198 4850229 APL_0715 Actinobacillus pleuropneumoniae serovar 5b str. L20 ABC transporter permease YP_001053420.1 825251 D 416269 CDS YP_001053421.1 126208196 4848954 826261..827139 1 NC_009053.1 iron(III) ABC transporter permease 827139 4848954 APL_0716 Actinobacillus pleuropneumoniae serovar 5b str. L20 iron(III) ABC transporter permease YP_001053421.1 826261 D 416269 CDS YP_001053422.1 126208197 4849885 827141..827899 1 NC_009053.1 iron(III) ABC transporter ATP-binding protein 827899 4849885 APL_0717 Actinobacillus pleuropneumoniae serovar 5b str. L20 iron(III) ABC transporter ATP-binding protein YP_001053422.1 827141 D 416269 CDS YP_001053423.1 126208198 4850330 828088..828768 1 NC_009053.1 hypothetical protein 828768 4850330 APL_0718 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053423.1 828088 D 416269 CDS YP_001053424.1 126208199 4849064 828778..830040 1 NC_009053.1 phosphate permease 830040 4849064 APL_0719 Actinobacillus pleuropneumoniae serovar 5b str. L20 phosphate permease YP_001053424.1 828778 D 416269 CDS YP_001053425.1 126208200 4849359 830104..830709 1 NC_009053.1 hypothetical protein 830709 4849359 APL_0720 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053425.1 830104 D 416269 CDS YP_001053426.1 126208201 4849126 complement(830763..830990) 1 NC_009053.1 hypothetical protein 830990 4849126 APL_0721 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053426.1 830763 R 416269 CDS YP_001053427.1 126208202 4849699 complement(830997..831512) 1 NC_009053.1 hypothetical protein 831512 4849699 APL_0722 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053427.1 830997 R 416269 CDS YP_001053428.1 126208203 4849571 complement(831585..832733) 1 NC_009053.1 Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr); queuine tRNA-ribosyltransferase 832733 tgt 4849571 tgt Actinobacillus pleuropneumoniae serovar 5b str. L20 queuine tRNA-ribosyltransferase YP_001053428.1 831585 R 416269 CDS YP_001053429.1 126208204 4849286 833056..833628 1 NC_009053.1 hypothetical protein 833628 4849286 APL_0724 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053429.1 833056 D 416269 CDS YP_001053430.1 126208205 4850493 833751..833942 1 NC_009053.1 cold shock-like protein CspD 833942 cspD 4850493 cspD Actinobacillus pleuropneumoniae serovar 5b str. L20 cold shock-like protein CspD YP_001053430.1 833751 D 416269 CDS YP_001053431.1 126208206 4848775 834060..834776 1 NC_009053.1 carbonic anhydrase 834776 4848775 APL_0726 Actinobacillus pleuropneumoniae serovar 5b str. L20 carbonic anhydrase YP_001053431.1 834060 D 416269 CDS YP_001053432.1 126208207 4848759 835093..836817 1 NC_009053.1 acetolactate synthase large subunit; catalyzes the formation of 2-acetolactate from pyruvate; acetolactate synthase 3 catalytic subunit 836817 ilvI 4848759 ilvI Actinobacillus pleuropneumoniae serovar 5b str. L20 acetolactate synthase 3 catalytic subunit YP_001053432.1 835093 D 416269 CDS YP_001053433.1 126208208 4850448 836810..837301 1 NC_009053.1 with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit; acetolactate synthase 3 regulatory subunit 837301 ilvH 4850448 ilvH Actinobacillus pleuropneumoniae serovar 5b str. L20 acetolactate synthase 3 regulatory subunit YP_001053433.1 836810 D 416269 CDS YP_001053434.1 126208209 4850502 complement(837571..838920) 1 NC_009053.1 antibiotic maturation factor 838920 pmbA 4850502 pmbA Actinobacillus pleuropneumoniae serovar 5b str. L20 antibiotic maturation factor YP_001053434.1 837571 R 416269 CDS YP_001053435.1 126208210 4848560 839028..839558 1 NC_009053.1 hypothetical protein 839558 4848560 APL_0730 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053435.1 839028 D 416269 CDS YP_001053436.1 126208211 4850255 839603..839974 1 NC_009053.1 hypothetical protein 839974 4850255 APL_0731 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053436.1 839603 D 416269 CDS YP_001053437.1 126208212 4848808 840034..840606 1 NC_009053.1 aromatic acid decarboxylase 840606 ubiX 4848808 ubiX Actinobacillus pleuropneumoniae serovar 5b str. L20 aromatic acid decarboxylase YP_001053437.1 840034 D 416269 CDS YP_001053438.1 126208213 4850551 840609..841322 1 NC_009053.1 hypothetical protein 841322 4850551 APL_0733 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053438.1 840609 D 416269 CDS YP_001053439.1 126208214 4849761 841369..841818 1 NC_009053.1 hypothetical protein 841818 4849761 APL_0734 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053439.1 841369 D 416269 CDS YP_001053440.1 126208215 4850544 complement(841891..842202) 1 NC_009053.1 involved in start site selection during the initiation of translation; translation initiation factor Sui1 842202 4850544 APL_0735 Actinobacillus pleuropneumoniae serovar 5b str. L20 translation initiation factor Sui1 YP_001053440.1 841891 R 416269 CDS YP_001053441.1 126208216 4849199 complement(842282..842974) 1 NC_009053.1 type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase; orotidine 5'-phosphate decarboxylase 842974 pyrF 4849199 pyrF Actinobacillus pleuropneumoniae serovar 5b str. L20 orotidine 5'-phosphate decarboxylase YP_001053441.1 842282 R 416269 CDS YP_001053442.1 126208217 4849523 complement(842999..844195) 1 NC_009053.1 hypothetical protein 844195 4849523 APL_0737 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053442.1 842999 R 416269 CDS YP_001053443.1 126208218 4849112 complement(844195..844485) 1 NC_009053.1 hypothetical protein 844485 4849112 APL_0738 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053443.1 844195 R 416269 CDS YP_001053444.1 126208219 4849982 complement(844554..844835) 1 NC_009053.1 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control; integration host factor subunit beta 844835 ihfB 4849982 ihfB Actinobacillus pleuropneumoniae serovar 5b str. L20 integration host factor subunit beta YP_001053444.1 844554 R 416269 CDS YP_001053445.1 126208220 4848897 complement(844909..846573) 1 NC_009053.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins; 30S ribosomal protein S1 846573 rpsA 4848897 rpsA Actinobacillus pleuropneumoniae serovar 5b str. L20 30S ribosomal protein S1 YP_001053445.1 844909 R 416269 CDS YP_001053446.1 126208221 4848859 complement(846670..847344) 1 NC_009053.1 cytidylate kinase 847344 cmkA 4848859 cmkA Actinobacillus pleuropneumoniae serovar 5b str. L20 cytidylate kinase YP_001053446.1 846670 R 416269 CDS YP_001053447.1 126208222 4850201 complement(847374..848405) 1 NC_009053.1 protease DegS 848405 degS 4850201 degS Actinobacillus pleuropneumoniae serovar 5b str. L20 protease DegS YP_001053447.1 847374 R 416269 CDS YP_001053448.1 126208223 4848977 complement(848654..848980) 1 NC_009053.1 preprotein translocase subunit SecG 848980 secG 4848977 secG Actinobacillus pleuropneumoniae serovar 5b str. L20 preprotein translocase subunit SecG YP_001053448.1 848654 R 416269 CDS YP_001053449.1 126208224 4848998 complement(849112..851049) 1 NC_009053.1 decatenates replicating daughter chromosomes; DNA topoisomerase III 851049 topB2 4848998 topB2 Actinobacillus pleuropneumoniae serovar 5b str. L20 DNA topoisomerase III YP_001053449.1 849112 R 416269 CDS YP_001053450.1 126208225 4850197 complement(852612..853442) 1 NC_009053.1 D-alanyl-D-alanine endopeptidase; functions in hydrolyzing cell wall peptidoglycan; similar to LAS metallopeptidases; forms a dimer in periplasm; penicillin-insensitive murein endopeptidase 853442 mepA 4850197 mepA Actinobacillus pleuropneumoniae serovar 5b str. L20 penicillin-insensitive murein endopeptidase YP_001053450.1 852612 R 416269 CDS YP_001053451.1 126208226 4848838 complement(853537..854619) 1 NC_009053.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis; chorismate synthase 854619 aroC 4848838 aroC Actinobacillus pleuropneumoniae serovar 5b str. L20 chorismate synthase YP_001053451.1 853537 R 416269 CDS YP_001053452.1 126208227 4849695 complement(854641..857949) 1 NC_009053.1 small mechanosensitive ion channel (MscS) that opens in response to stretch forces in the membrane lipid bilayer; maintains cell turgor through accumulation and release of potassium; large protein class of MscS; potassium efflux protein KefA 857949 4849695 APL_0749 Actinobacillus pleuropneumoniae serovar 5b str. L20 potassium efflux protein KefA YP_001053452.1 854641 R 416269 CDS YP_001053453.1 126208228 4849564 complement(857967..861311) 1 NC_009053.1 small mechanosensitive ion channel (MscS) that opens in response to stretch forces in the membrane lipid bilayer; maintains cell turgor through accumulation and release of potassium; large protein class of MscS; potassium efflux protein KefA 861311 4849564 APL_0750 Actinobacillus pleuropneumoniae serovar 5b str. L20 potassium efflux protein KefA YP_001053453.1 857967 R 416269 CDS YP_001053454.1 126208229 4850325 complement(861292..862722) 1 NC_009053.1 O-succinylbenzoic acid--CoA ligase 862722 menE 4850325 menE Actinobacillus pleuropneumoniae serovar 5b str. L20 O-succinylbenzoic acid--CoA ligase YP_001053454.1 861292 R 416269 CDS YP_001053455.1 126208230 4849176 complement(862740..863300) 1 NC_009053.1 negative modulator of the initiation of chromosome replication; replication initiation regulator SeqA 863300 seqA 4849176 seqA Actinobacillus pleuropneumoniae serovar 5b str. L20 replication initiation regulator SeqA YP_001053455.1 862740 R 416269 CDS YP_001053456.1 126208231 4849325 863424..864209 1 NC_009053.1 esterase/lipase 864209 4849325 APL_0753 Actinobacillus pleuropneumoniae serovar 5b str. L20 esterase/lipase YP_001053456.1 863424 D 416269 CDS YP_001053457.1 126208232 4850360 864217..864942 1 NC_009053.1 S-adenosyl-L-methionine-dependent methyltransferase 864942 yecO 4850360 yecO Actinobacillus pleuropneumoniae serovar 5b str. L20 S-adenosyl-L-methionine-dependent methyltransferase YP_001053457.1 864217 D 416269 CDS YP_001053458.1 126208233 4850419 865141..865929 1 NC_009053.1 enoyl-ACP reductase 865929 fabI 4850419 fabI Actinobacillus pleuropneumoniae serovar 5b str. L20 enoyl-ACP reductase YP_001053458.1 865141 D 416269 CDS YP_001053459.1 126208234 4849324 866377..866655 1 NC_009053.1 hypothetical protein 866655 4849324 APL_0756 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053459.1 866377 D 416269 CDS YP_001053460.1 126208235 4850359 866787..868763 1 NC_009053.1 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction; exoribonuclease II 868763 rnb 4850359 rnb Actinobacillus pleuropneumoniae serovar 5b str. L20 exoribonuclease II YP_001053460.1 866787 D 416269 CDS YP_001053461.1 126208236 4849238 868838..869209 1 NC_009053.1 hypothetical protein 869209 4849238 APL_0758 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053461.1 868838 D 416269 CDS YP_001053462.1 126208237 4848766 869206..869892 1 NC_009053.1 hypothetical protein 869892 4848766 APL_0759 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053462.1 869206 D 416269 CDS YP_001053463.1 126208238 4849814 869917..870729 1 NC_009053.1 hydrolyzes P(1),P(4)-bis(5'-adenosyl) tetraphosphate to form 2 ADP; diadenosine tetraphosphatase 870729 apaH 4849814 apaH Actinobacillus pleuropneumoniae serovar 5b str. L20 diadenosine tetraphosphatase YP_001053463.1 869917 D 416269 CDS YP_001053464.1 126208239 4848461 complement(870918..871160) 1 NC_009053.1 hypothetical protein 871160 4848461 APL_0761 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053464.1 870918 R 416269 CDS YP_001053465.1 126208240 4850338 871328..872083 1 NC_009053.1 hypothetical protein 872083 4850338 APL_0762 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053465.1 871328 D 416269 CDS YP_001053466.1 126208241 4849955 872142..873203 1 NC_009053.1 permease perM-like protein 873203 perM 4849955 perM Actinobacillus pleuropneumoniae serovar 5b str. L20 permease perM-like protein YP_001053466.1 872142 D 416269 CDS YP_001053467.1 126208242 4850215 873233..874162 1 NC_009053.1 hypothetical protein 874162 4850215 APL_0764 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053467.1 873233 D 416269 CDS YP_001053468.1 126208243 4849804 874210..875295 1 NC_009053.1 Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step; S-adenosylmethionine--tRNA ribosyltransferase-isomerase 875295 queA 4849804 queA Actinobacillus pleuropneumoniae serovar 5b str. L20 S-adenosylmethionine--tRNA ribosyltransferase-isomerase YP_001053468.1 874210 D 416269 CDS YP_001053469.1 126208244 4849683 complement(875330..877624) 1 NC_009053.1 recombination protein 2 877624 rec2 4849683 rec2 Actinobacillus pleuropneumoniae serovar 5b str. L20 recombination protein 2 YP_001053469.1 875330 R 416269 CDS YP_001053470.1 126208245 4849414 complement(877724..878938) 1 NC_009053.1 involved in the import of serine and threonine coupled with the import of sodium; serine/threonine transporter SstT 878938 4849414 APL_0767 Actinobacillus pleuropneumoniae serovar 5b str. L20 serine/threonine transporter SstT YP_001053470.1 877724 R 416269 CDS YP_001053471.1 126208246 4850028 879187..879549 1 NC_009053.1 diacylglycerol kinase 879549 dgkA 4850028 dgkA Actinobacillus pleuropneumoniae serovar 5b str. L20 diacylglycerol kinase YP_001053471.1 879187 D 416269 CDS YP_001053472.1 126208247 4849444 879630..881273 1 NC_009053.1 catalyzes the degradation of periplasmic UDP-glucose to uridine, glucose-1-phosphate and inorganic phosphate; specific for uridine nucleotides; bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic 881273 ushA 4849444 ushA Actinobacillus pleuropneumoniae serovar 5b str. L20 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic YP_001053472.1 879630 D 416269 CDS YP_001053473.1 126208248 4849545 881728..882330 1 NC_009053.1 hypothetical protein 882330 4849545 APL_0770 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053473.1 881728 D 416269 CDS YP_001053474.1 126208249 4849746 complement(883954..885378) 1 NC_009053.1 E3 component of pyruvate and 2-oxoglutarate dehydrogenase complex; catalyzes the oxidation of dihydrolipoamide to lipoamide; dihydrolipoamide dehydrogenase 885378 lpdA 4849746 lpdA Actinobacillus pleuropneumoniae serovar 5b str. L20 dihydrolipoamide dehydrogenase YP_001053474.1 883954 R 416269 CDS YP_001053475.1 126208250 4849635 complement(885474..887372) 1 NC_009053.1 E2 component of pyruvate dehydrogenase multienzyme complex; in Escherichia coli AceF contains three N-terminal lipoyl domains; dihydrolipoamide acetyltransferase 887372 aceF 4849635 aceF Actinobacillus pleuropneumoniae serovar 5b str. L20 dihydrolipoamide acetyltransferase YP_001053475.1 885474 R 416269 CDS YP_001053476.1 126208251 4849055 complement(887432..890086) 1 NC_009053.1 E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC; pyruvate dehydrogenase subunit E1 890086 aceE 4849055 aceE Actinobacillus pleuropneumoniae serovar 5b str. L20 pyruvate dehydrogenase subunit E1 YP_001053476.1 887432 R 416269 CDS YP_001053477.1 126208252 4849059 complement(890441..891448) 1 NC_009053.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors; dihydroorotate dehydrogenase 2 891448 pyrD 4849059 pyrD Actinobacillus pleuropneumoniae serovar 5b str. L20 dihydroorotate dehydrogenase 2 YP_001053477.1 890441 R 416269 CDS YP_001053478.1 126208253 4849903 complement(891522..892472) 1 NC_009053.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase 892472 prsA 4849903 prsA Actinobacillus pleuropneumoniae serovar 5b str. L20 ribose-phosphate pyrophosphokinase YP_001053478.1 891522 R 416269 CDS YP_001053479.1 126208254 4850291 complement(892484..893341) 1 NC_009053.1 An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis; 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 893341 ipk 4850291 ipk Actinobacillus pleuropneumoniae serovar 5b str. L20 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase YP_001053479.1 892484 R 416269 CDS YP_001053480.1 126208255 4848899 complement(893351..893983) 1 NC_009053.1 Incorporates lipoproteins in the outer membrane after they are released by the LolA protein; outer membrane lipoprotein LolB 893983 lolB 4848899 lolB Actinobacillus pleuropneumoniae serovar 5b str. L20 outer membrane lipoprotein LolB YP_001053480.1 893351 R 416269 CDS YP_001053481.1 126208256 4850141 complement(894112..895860) 1 NC_009053.1 involved in the transport of lipid A across the inner membrane; lipid transporter ATP-binding protein/permease 895860 msbA 4850141 msbA Actinobacillus pleuropneumoniae serovar 5b str. L20 lipid transporter ATP-binding protein/permease YP_001053481.1 894112 R 416269 CDS YP_001053482.1 126208257 4850262 complement(895965..896651) 1 NC_009053.1 hypothetical protein 896651 4850262 APL_0779 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053482.1 895965 R 416269 CDS YP_001053483.1 126208258 4850300 complement(896661..897020) 1 NC_009053.1 hypothetical protein 897020 4850300 APL_0780 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053483.1 896661 R 416269 CDS YP_001053484.1 126208259 4848640 complement(897087..899009) 1 NC_009053.1 ATP-dependent helicase 899009 4848640 APL_0781 Actinobacillus pleuropneumoniae serovar 5b str. L20 ATP-dependent helicase YP_001053484.1 897087 R 416269 CDS YP_001053485.1 126208260 4850311 complement(899489..902317) 1 NC_009053.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate; excinuclease ABC subunit A 902317 uvrA 4850311 uvrA Actinobacillus pleuropneumoniae serovar 5b str. L20 excinuclease ABC subunit A YP_001053485.1 899489 R 416269 CDS YP_001053486.1 126208261 4848611 902468..902992 1 NC_009053.1 binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA; single-stranded DNA-binding protein 902992 ssb 4848611 ssb Actinobacillus pleuropneumoniae serovar 5b str. L20 single-stranded DNA-binding protein YP_001053486.1 902468 D 416269 CDS YP_001053487.1 126208262 4849461 complement(903161..903979) 1 NC_009053.1 hypothetical protein 903979 4849461 APL_0784 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053487.1 903161 R 416269 CDS YP_001053488.1 126208263 4848781 complement(904303..906294) 1 NC_009053.1 hypothetical protein 906294 4848781 APL_0785 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053488.1 904303 R 416269 CDS YP_001053489.1 126208264 4849488 complement(906716..907804) 1 NC_009053.1 hypothetical protein 907804 4849488 APL_0786 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053489.1 906716 R 416269 CDS YP_001053490.1 126208265 4849802 complement(907871..909199) 1 NC_009053.1 ATPase 909199 4849802 APL_0787 Actinobacillus pleuropneumoniae serovar 5b str. L20 ATPase YP_001053490.1 907871 R 416269 CDS YP_001053491.1 126208266 4848968 complement(909512..910399) 1 NC_009053.1 transcriptional regulator 910399 4848968 APL_0788 Actinobacillus pleuropneumoniae serovar 5b str. L20 transcriptional regulator YP_001053491.1 909512 R 416269 CDS YP_001053492.1 126208267 4849149 910504..911478 1 NC_009053.1 dioxygenase 911478 4849149 APL_0789 Actinobacillus pleuropneumoniae serovar 5b str. L20 dioxygenase YP_001053492.1 910504 D 416269 CDS YP_001053493.1 126208268 4850059 complement(913424..914191) 1 NC_009053.1 hypothetical protein 914191 4850059 APL_0792 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053493.1 913424 R 416269 CDS YP_001053494.1 126208269 4849957 complement(914274..915311) 1 NC_009053.1 peptide transport system ATP-binding protein SapD 915311 sapD 4849957 sapD Actinobacillus pleuropneumoniae serovar 5b str. L20 peptide transport system ATP-binding protein SapD YP_001053494.1 914274 R 416269 CDS YP_001053495.1 126208270 4850239 complement(915325..916212) 1 NC_009053.1 peptide transport system permease SapC 916212 sapC 4850239 sapC Actinobacillus pleuropneumoniae serovar 5b str. L20 peptide transport system permease SapC YP_001053495.1 915325 R 416269 CDS YP_001053496.1 126208271 4849406 complement(916202..917164) 1 NC_009053.1 peptide transport system permease SapB 917164 sapB 4849406 sapB Actinobacillus pleuropneumoniae serovar 5b str. L20 peptide transport system permease SapB YP_001053496.1 916202 R 416269 CDS YP_001053497.1 126208272 4850200 complement(917164..918861) 1 NC_009053.1 peptide transport periplasmic protein SapA 918861 sapA 4850200 sapA Actinobacillus pleuropneumoniae serovar 5b str. L20 peptide transport periplasmic protein SapA YP_001053497.1 917164 R 416269 CDS YP_001053498.1 126208273 4848644 complement(918871..920019) 1 NC_009053.1 transcriptional regulatory protein TyrR 920019 tyrR 4848644 tyrR Actinobacillus pleuropneumoniae serovar 5b str. L20 transcriptional regulatory protein TyrR YP_001053498.1 918871 R 416269 CDS YP_001053499.1 126208274 4849187 920224..920808 1 NC_009053.1 catalyzes the isomerization of sedoheptulose 7-phosphate to D-glycero-D-manno-heptose 7-phosphate; phosphoheptose isomerase 920808 gmhA 4849187 gmhA Actinobacillus pleuropneumoniae serovar 5b str. L20 phosphoheptose isomerase YP_001053499.1 920224 D 416269 CDS YP_001053500.1 126208275 4849393 921300..921911 1 NC_009053.1 hypothetical protein 921911 4849393 APL_0799 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053500.1 921300 D 416269 CDS YP_001053501.1 126208276 4848958 complement(922121..923731) 1 NC_009053.1 PEP carboxykinase; PEP carboxylase; PEPCK; catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using ATP; phosphoenolpyruvate carboxykinase 923731 pckA 4848958 pckA Actinobacillus pleuropneumoniae serovar 5b str. L20 phosphoenolpyruvate carboxykinase YP_001053501.1 922121 R 416269 CDS YP_001053502.1 126208277 4849566 924004..924282 1 NC_009053.1 cell division protein FtsB-like protein 924282 ftsB 4849566 ftsB Actinobacillus pleuropneumoniae serovar 5b str. L20 cell division protein FtsB-like protein YP_001053502.1 924004 D 416269 CDS YP_001053503.1 126208278 4850225 924298..924984 1 NC_009053.1 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 924984 ispD 4850225 ispD Actinobacillus pleuropneumoniae serovar 5b str. L20 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase YP_001053503.1 924298 D 416269 CDS YP_001053504.1 126208279 4850073 924981..925457 1 NC_009053.1 catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate; 2-C-methyl-D-erythritol 2,4-cyclo diphosphate synthase 925457 ispF 4850073 ispF Actinobacillus pleuropneumoniae serovar 5b str. L20 2-C-methyl-D-erythritol 2,4-cyclo diphosphate synthase YP_001053504.1 924981 D 416269 CDS YP_001053505.1 126208280 4850211 complement(926126..928102) 1 NC_009053.1 hypothetical protein 928102 4850211 APL_0804 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053505.1 926126 R 416269 CDS YP_001053506.1 126208281 4848840 complement(928140..928928) 1 NC_009053.1 hypothetical protein 928928 4848840 APL_0805 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053506.1 928140 R 416269 CDS YP_001053507.1 126208282 4849309 929073..929297 1 NC_009053.1 catalyzes the bidirectional exonucleolytic cleavage of DNA; exodeoxyribonuclease VII small subunit 929297 xseB 4849309 xseB Actinobacillus pleuropneumoniae serovar 5b str. L20 exodeoxyribonuclease VII small subunit YP_001053507.1 929073 D 416269 CDS YP_001053508.1 126208283 4850324 929306..930199 1 NC_009053.1 geranyltranstransferase 930199 ispA 4850324 ispA Actinobacillus pleuropneumoniae serovar 5b str. L20 geranyltranstransferase YP_001053508.1 929306 D 416269 CDS YP_001053509.1 126208284 4849333 complement(930283..930627) 1 NC_009053.1 hypothetical protein 930627 4849333 APL_0808 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053509.1 930283 R 416269 CDS YP_001053510.1 126208285 4849593 complement(930728..932230) 1 NC_009053.1 class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1; lysyl-tRNA synthetase 932230 lysS 4849593 lysS Actinobacillus pleuropneumoniae serovar 5b str. L20 lysyl-tRNA synthetase YP_001053510.1 930728 R 416269 CDS YP_001053511.1 126208286 4849973 complement(932365..933840) 1 NC_009053.1 involved in the processing of the 5'end of 16S rRNA; ribonuclease G 933840 cafA 4849973 cafA Actinobacillus pleuropneumoniae serovar 5b str. L20 ribonuclease G YP_001053511.1 932365 R 416269 CDS YP_001053512.1 126208287 4848751 934070..935833 1 NC_009053.1 hypothetical protein 935833 4848751 APL_0811 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053512.1 934070 D 416269 CDS YP_001053513.1 126208288 4849815 complement(935866..938478) 1 NC_009053.1 type III restriction enzyme 938478 res 4849815 res Actinobacillus pleuropneumoniae serovar 5b str. L20 type III restriction enzyme YP_001053513.1 935866 R 416269 CDS YP_001053514.1 126208289 4849673 complement(938618..940465) 1 NC_009053.1 type III restriction-modification system methyltransferase 940465 mod 4849673 mod Actinobacillus pleuropneumoniae serovar 5b str. L20 type III restriction-modification system methyltransferase YP_001053514.1 938618 R 416269 CDS YP_001053515.1 126208290 4850246 940675..941637 1 NC_009053.1 hypothetical protein 941637 4850246 APL_0814 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053515.1 940675 D 416269 CDS YP_001053516.1 126208291 4848762 941783..942118 1 NC_009053.1 hypothetical protein 942118 4848762 APL_0815 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053516.1 941783 D 416269 CDS YP_001053517.1 126208292 4849552 complement(942185..943282) 1 NC_009053.1 membrane-bound, lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; murein transglycosylase A 943282 mltA 4849552 mltA Actinobacillus pleuropneumoniae serovar 5b str. L20 murein transglycosylase A YP_001053517.1 942185 R 416269 CDS YP_001053518.1 126208293 4848764 943691..945151 1 NC_009053.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides; exodeoxyribonuclease VII large subunit 945151 xseA 4848764 xseA Actinobacillus pleuropneumoniae serovar 5b str. L20 exodeoxyribonuclease VII large subunit YP_001053518.1 943691 D 416269 CDS YP_001053519.1 126208294 4850323 complement(945527..945940) 1 NC_009053.1 transthyretin-like periplasmic protein 945940 4850323 APL_0818 Actinobacillus pleuropneumoniae serovar 5b str. L20 transthyretin-like periplasmic protein YP_001053519.1 945527 R 416269 CDS YP_001053520.1 126208295 4849135 946139..947149 1 NC_009053.1 binds to the purF operator and coregulates other genes for de novo purine nucleotide synthesis; is involved in regulation of purB, purC, purEK, purHD, purL, purMN and guaBA expression; binds hypoxanthine and guanine as inducers; DNA-binding transcriptional repressor PurR 947149 purR 4849135 purR Actinobacillus pleuropneumoniae serovar 5b str. L20 DNA-binding transcriptional repressor PurR YP_001053520.1 946139 D 416269 CDS YP_001053521.1 126208296 4849330 947172..947774 1 NC_009053.1 membrane-associated protein 947774 4849330 APL_0820 Actinobacillus pleuropneumoniae serovar 5b str. L20 membrane-associated protein YP_001053521.1 947172 D 416269 CDS YP_001053522.1 126208297 4850065 complement(947874..950306) 1 NC_009053.1 DNA gyrase subunit B 950306 gyrB 4850065 gyrB Actinobacillus pleuropneumoniae serovar 5b str. L20 DNA gyrase subunit B YP_001053522.1 947874 R 416269 CDS YP_001053523.1 126208298 4850044 complement(950519..951400) 1 NC_009053.1 catalyzes the conversion of 4-Hydroxybenzoate into 3-octaprenyl-4-hydroxybenzoate, as part of the ubiquinone biosynthesis pathway; 4-hydroxybenzoate octaprenyltransferase 951400 ubiA 4850044 ubiA Actinobacillus pleuropneumoniae serovar 5b str. L20 4-hydroxybenzoate octaprenyltransferase YP_001053523.1 950519 R 416269 CDS YP_001053524.1 126208299 4849004 complement(951400..952161) 1 NC_009053.1 glycerol-3-phosphate regulon repressor 952161 glpR 4849004 glpR Actinobacillus pleuropneumoniae serovar 5b str. L20 glycerol-3-phosphate regulon repressor YP_001053524.1 951400 R 416269 CDS YP_001053525.1 126208300 4849396 complement(952229..953596) 1 NC_009053.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; adenylosuccinate lyase 953596 purB 4849396 purB Actinobacillus pleuropneumoniae serovar 5b str. L20 adenylosuccinate lyase YP_001053525.1 952229 R 416269 CDS YP_001053526.1 126208301 4850190 complement(953653..954285) 1 NC_009053.1 HflD; UPF0274; in Escherichia coli this protein is peripherally associated with the membrane and appears to act with lambda CII protein; in Haemophilus influenzae a knockout of the HI0638 gene affected paracytosis; hypothetical protein 954285 4850190 APL_0825 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053526.1 953653 R 416269 CDS YP_001053527.1 126208302 4849282 complement(954450..956117) 1 NC_009053.1 in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c; cysteine/glutathione ABC transporter membrane/ATP-binding protein 956117 cydC 4849282 cydC Actinobacillus pleuropneumoniae serovar 5b str. L20 cysteine/glutathione ABC transporter membrane/ATP-binding protein YP_001053527.1 954450 R 416269 CDS YP_001053528.1 126208303 4849570 complement(956128..957870) 1 NC_009053.1 in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c; cysteine/glutathione ABC transporter membrane/ATP-binding protein 957870 cydD 4849570 cydD Actinobacillus pleuropneumoniae serovar 5b str. L20 cysteine/glutathione ABC transporter membrane/ATP-binding protein YP_001053528.1 956128 R 416269 CDS YP_001053529.1 126208304 4848988 complement(958030..961989) 1 NC_009053.1 hypothetical protein 961989 4848988 APL_0828 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053529.1 958030 R 416269 CDS YP_001053530.1 126208305 4848551 complement(962050..963876) 1 NC_009053.1 hypothetical protein 963876 4848551 APL_0829 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053530.1 962050 R 416269 CDS YP_001053531.1 126208306 4849001 complement(963892..964740) 1 NC_009053.1 hypothetical protein 964740 4849001 APL_0830 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053531.1 963892 R 416269 CDS YP_001053532.1 126208307 4848739 complement(964740..965939) 1 NC_009053.1 membrane-bound metallopeptidase 965939 4848739 APL_0831 Actinobacillus pleuropneumoniae serovar 5b str. L20 membrane-bound metallopeptidase YP_001053532.1 964740 R 416269 CDS YP_001053533.1 126208308 4848641 966118..966801 1 NC_009053.1 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate; phosphoglyceromutase 966801 gpmA 4848641 gpmA Actinobacillus pleuropneumoniae serovar 5b str. L20 phosphoglyceromutase YP_001053533.1 966118 D 416269 CDS YP_001053534.1 126208309 4848802 complement(966885..967520) 1 NC_009053.1 hypothetical protein 967520 4848802 APL_0833 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053534.1 966885 R 416269 CDS YP_001053535.1 126208310 4849621 967638..968291 1 NC_009053.1 functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor; uridine kinase 968291 udk 4849621 udk Actinobacillus pleuropneumoniae serovar 5b str. L20 uridine kinase YP_001053535.1 967638 D 416269 CDS YP_001053536.1 126208311 4849342 968300..968884 1 NC_009053.1 Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis; deoxycytidine triphosphate deaminase 968884 dcd 4849342 dcd Actinobacillus pleuropneumoniae serovar 5b str. L20 deoxycytidine triphosphate deaminase YP_001053536.1 968300 D 416269 CDS YP_001053537.1 126208312 4849542 complement(968953..969507) 1 NC_009053.1 transcriptional regulator 969507 4849542 APL_0836 Actinobacillus pleuropneumoniae serovar 5b str. L20 transcriptional regulator YP_001053537.1 968953 R 416269 CDS YP_001053538.1 126208313 4849069 969648..970709 1 NC_009053.1 hypothetical protein 970709 4849069 APL_0837 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053538.1 969648 D 416269 CDS YP_001053539.1 126208314 4850235 970713..973454 1 NC_009053.1 ABC transporter ATP-binding protein 973454 4850235 APL_0838 Actinobacillus pleuropneumoniae serovar 5b str. L20 ABC transporter ATP-binding protein YP_001053539.1 970713 D 416269 CDS YP_001053540.1 126208315 4849830 973456..974580 1 NC_009053.1 inner membrane transport permease 974580 4849830 APL_0839 Actinobacillus pleuropneumoniae serovar 5b str. L20 inner membrane transport permease YP_001053540.1 973456 D 416269 CDS YP_001053541.1 126208316 4849516 974597..975991 1 NC_009053.1 outer membrane protein 975991 4849516 APL_0840 Actinobacillus pleuropneumoniae serovar 5b str. L20 outer membrane protein YP_001053541.1 974597 D 416269 CDS YP_001053542.1 126208317 4848714 complement(976069..977517) 1 NC_009053.1 catalyzes reversible transfer of hydride ion equivalent between NAD and NADP; membrane-bound proton pump that translocates protons from cytosolic to periplasmic side of the inner membrane; forms a tetramer composed of two alpha and 2 beta subunits; AB-stereospecific enzyme; pyridine nucleotide transhydrogenase 977517 pntB 4848714 pntB Actinobacillus pleuropneumoniae serovar 5b str. L20 pyridine nucleotide transhydrogenase YP_001053542.1 976069 R 416269 CDS YP_001053543.1 126208318 4849810 complement(977528..979066) 1 NC_009053.1 forms a tetramer composed of 2 alpha subunits and 2 beta subunits in the inner membrane; involved in catalyzing transfer of hydride ion equivalents between NAD and NADP; stereospecific (AB-specific); functions as a proton pump by translocating protons from cytoplasm to periplasm; NAD(P) transhydrogenase subunit alpha 979066 pntA 4849810 pntA Actinobacillus pleuropneumoniae serovar 5b str. L20 NAD(P) transhydrogenase subunit alpha YP_001053543.1 977528 R 416269 CDS YP_001053544.1 126208319 4849914 979271..980002 1 NC_009053.1 tRNA/rRNA methyltransferase 980002 4849914 APL_0843 Actinobacillus pleuropneumoniae serovar 5b str. L20 tRNA/rRNA methyltransferase YP_001053544.1 979271 D 416269 CDS YP_001053545.1 126208320 4850362 complement(980048..980887) 1 NC_009053.1 catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) in queuosine biosynthesis; 7-cyano-7-deazaguanine reductase 980887 queF 4850362 queF Actinobacillus pleuropneumoniae serovar 5b str. L20 7-cyano-7-deazaguanine reductase YP_001053545.1 980048 R 416269 CDS YP_001053546.1 126208321 4848689 complement(980900..981445) 1 NC_009053.1 Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1-phosphate; D,D-heptose 1,7-bisphosphate phosphatase 981445 gmhB 4848689 gmhB Actinobacillus pleuropneumoniae serovar 5b str. L20 D,D-heptose 1,7-bisphosphate phosphatase YP_001053546.1 980900 R 416269 CDS YP_001053547.1 126208322 4849873 complement(981448..981918) 1 NC_009053.1 bacterioferritin comigratory protein; thiol peroxidase; thioredoxin-dependent; hydroperoxide peroxidase; in Escherichia coli this enzyme preferentially reduces linoleic acid hydroperoxide; contains an active site cysteine; thioredoxin-dependent thiol peroxidase 981918 bcp 4849873 bcp Actinobacillus pleuropneumoniae serovar 5b str. L20 thioredoxin-dependent thiol peroxidase YP_001053547.1 981448 R 416269 CDS YP_001053548.1 126208323 4849506 complement(981993..983150) 1 NC_009053.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 983150 4849506 APL_0847 Actinobacillus pleuropneumoniae serovar 5b str. L20 coproporphyrinogen III oxidase YP_001053548.1 981993 R 416269 CDS YP_001053549.1 126208324 4850266 983413..984987 1 NC_009053.1 ABC transporter substrate-binding protein 984987 4850266 APL_0848 Actinobacillus pleuropneumoniae serovar 5b str. L20 ABC transporter substrate-binding protein YP_001053549.1 983413 D 416269 CDS YP_001053550.1 126208325 4849824 985086..986039 1 NC_009053.1 inner membrane ABC transporter permease 986039 4849824 APL_0849 Actinobacillus pleuropneumoniae serovar 5b str. L20 inner membrane ABC transporter permease YP_001053550.1 985086 D 416269 CDS YP_001053551.1 126208326 4849075 986039..988012 1 NC_009053.1 ABC transporter ATP-binding protein/permease 988012 4849075 APL_0850 Actinobacillus pleuropneumoniae serovar 5b str. L20 ABC transporter ATP-binding protein/permease YP_001053551.1 986039 D 416269 CDS YP_001053552.1 126208327 4849258 988016..988822 1 NC_009053.1 ABC transporter ATP-binding protein 988822 4849258 APL_0851 Actinobacillus pleuropneumoniae serovar 5b str. L20 ABC transporter ATP-binding protein YP_001053552.1 988016 D 416269 CDS YP_001053553.1 126208328 4848565 988874..990472 1 NC_009053.1 FAD flavoprotein oxidase 990472 4848565 APL_0852 Actinobacillus pleuropneumoniae serovar 5b str. L20 FAD flavoprotein oxidase YP_001053553.1 988874 D 416269 CDS YP_001053554.1 126208329 4849550 complement(990534..991691) 1 NC_009053.1 methionine synthase II (cobalamin-independent) 991691 4849550 APL_0853 Actinobacillus pleuropneumoniae serovar 5b str. L20 methionine synthase II (cobalamin-independent) YP_001053554.1 990534 R 416269 CDS YP_001053555.1 126208330 4848533 991911..992792 1 NC_009053.1 MTHFR; catalyzes NADH-linked reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate using FAD as a cofactor; 5,10-methylenetetrahydrofolate reductase 992792 metF 4848533 metF Actinobacillus pleuropneumoniae serovar 5b str. L20 5,10-methylenetetrahydrofolate reductase YP_001053555.1 991911 D 416269 CDS YP_001053556.1 126208331 4848937 complement(993070..994665) 1 NC_009053.1 heme-binding protein A 994665 hbpA 4848937 hbpA Actinobacillus pleuropneumoniae serovar 5b str. L20 heme-binding protein A YP_001053556.1 993070 R 416269 CDS YP_001053557.1 126208332 4849667 995022..996251 1 NC_009053.1 serine transporter 996251 sdaC 4849667 sdaC Actinobacillus pleuropneumoniae serovar 5b str. L20 serine transporter YP_001053557.1 995022 D 416269 CDS YP_001053558.1 126208333 4849245 996347..997726 1 NC_009053.1 L-serine dehydratase 997726 sdaA 4849245 sdaA Actinobacillus pleuropneumoniae serovar 5b str. L20 L-serine dehydratase YP_001053558.1 996347 D 416269 CDS YP_001053559.1 126208334 4849445 complement(997904..999919) 1 NC_009053.1 catalyzes the formation of 5-methylaminomethyl-2-thiouridine in position 34 of the anticodon of tRNA molecules; 5-methylaminomethyl-2-thiouridine methyltransferase 999919 mnmC 4849445 mnmC Actinobacillus pleuropneumoniae serovar 5b str. L20 5-methylaminomethyl-2-thiouridine methyltransferase YP_001053559.1 997904 R 416269 CDS YP_001053560.1 126208335 4849255 complement(1000124..1001533) 1 NC_009053.1 monomeric bifunctional protein; functions in tryptophan biosynthesis pathway; phosphoribosylanthranilate is rearranged to carboxyphenylaminodeoxyribulosephosphate which is then closed to form indole-3-glycerol phosphate; bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase 1001533 trpCF 4849255 trpCF Actinobacillus pleuropneumoniae serovar 5b str. L20 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase YP_001053560.1 1000124 R 416269 CDS YP_001053561.1 126208336 4848695 1001711..1002376 1 NC_009053.1 filamentation induced by cAMP protein Fic-like protein 1002376 fic 4848695 fic Actinobacillus pleuropneumoniae serovar 5b str. L20 filamentation induced by cAMP protein Fic-like protein YP_001053561.1 1001711 D 416269 CDS YP_001053562.1 126208337 4849624 1002384..1002695 1 NC_009053.1 hypothetical protein 1002695 4849624 APL_0861 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053562.1 1002384 D 416269 CDS YP_001053563.1 126208338 4849094 1002696..1003439 1 NC_009053.1 catalyzes formation of pseudouridine at position 65 in tRNA-Ile1 and tRNA-Asp; tRNA pseudouridine synthase C 1003439 truC 4849094 truC Actinobacillus pleuropneumoniae serovar 5b str. L20 tRNA pseudouridine synthase C YP_001053563.1 1002696 D 416269 CDS YP_001053564.1 126208339 4849950 1003441..1003605 1 NC_009053.1 hypothetical protein 1003605 4849950 APL_0863 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053564.1 1003441 D 416269 CDS YP_001053565.1 126208340 4849652 1003602..1004054 1 NC_009053.1 hypothetical protein 1004054 4849652 APL_0864 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053565.1 1003602 D 416269 CDS YP_001053566.1 126208341 4849365 complement(1004099..1004938) 1 NC_009053.1 hypothetical protein 1004938 aape0934 4849365 aape0934 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053566.1 1004099 R 416269 CDS YP_001053567.1 126208342 4848538 1004961..1006415 1 NC_009053.1 hypothetical protein 1006415 4848538 APL_0866 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053567.1 1004961 D 416269 CDS YP_001053568.1 126208343 4849572 1006549..1007028 1 NC_009053.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation; SsrA-binding protein 1007028 smpB 4849572 smpB Actinobacillus pleuropneumoniae serovar 5b str. L20 SsrA-binding protein YP_001053568.1 1006549 D 416269 CDS YP_001053569.1 126208344 4850467 1007146..1008453 1 NC_009053.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; seryl-tRNA synthetase 1008453 serS 4850467 serS Actinobacillus pleuropneumoniae serovar 5b str. L20 seryl-tRNA synthetase YP_001053569.1 1007146 D 416269 CDS YP_001053570.1 126208345 4849082 complement(1008524..1009792) 1 NC_009053.1 aminobenzoyl-glutamate utilization-like protein 1009792 abgB 4849082 abgB Actinobacillus pleuropneumoniae serovar 5b str. L20 aminobenzoyl-glutamate utilization-like protein YP_001053570.1 1008524 R 416269 CDS YP_001053571.1 126208346 4848851 complement(1009886..1011178) 1 NC_009053.1 C4-dicarboxylate transporter 1011178 4848851 APL_0870 Actinobacillus pleuropneumoniae serovar 5b str. L20 C4-dicarboxylate transporter YP_001053571.1 1009886 R 416269 CDS YP_001053572.1 126208347 4850173 complement(1011189..1011893) 1 NC_009053.1 alpha-aspartyl dipeptidase; catalyzes the hydrolysis of dipeptides with an N-terminal aspartate residue; belongs to peptidase S51 family; peptidase E 1011893 pepE 4850173 pepE Actinobacillus pleuropneumoniae serovar 5b str. L20 peptidase E YP_001053572.1 1011189 R 416269 CDS YP_001053573.1 126208348 4849039 1012144..1014729 1 NC_009053.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase; leucyl-tRNA synthetase 1014729 leuS 4849039 leuS Actinobacillus pleuropneumoniae serovar 5b str. L20 leucyl-tRNA synthetase YP_001053573.1 1012144 D 416269 CDS YP_001053574.1 126208349 4849269 1014837..1015331 1 NC_009053.1 rare lipoprotein B 1015331 rlpB 4849269 rlpB Actinobacillus pleuropneumoniae serovar 5b str. L20 rare lipoprotein B YP_001053574.1 1014837 D 416269 CDS YP_001053575.1 126208350 4849510 1015440..1016465 1 NC_009053.1 required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA; DNA polymerase III subunit delta 1016465 holA 4849510 holA Actinobacillus pleuropneumoniae serovar 5b str. L20 DNA polymerase III subunit delta YP_001053575.1 1015440 D 416269 CDS YP_001053576.1 126208351 4849655 complement(1016542..1016730) 1 NC_009053.1 zinc-binding protein 1016730 yacG 4849655 yacG Actinobacillus pleuropneumoniae serovar 5b str. L20 zinc-binding protein YP_001053576.1 1016542 R 416269 CDS YP_001053577.1 126208352 4848625 complement(1016712..1017350) 1 NC_009053.1 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis; dephospho-CoA kinase 1017350 coaE 4848625 coaE Actinobacillus pleuropneumoniae serovar 5b str. L20 dephospho-CoA kinase YP_001053577.1 1016712 R 416269 CDS YP_001053578.1 126208353 4850263 complement(1017372..1018010) 1 NC_009053.1 pubmed:14742510; fimbrial leader peptidase 1018010 apfD 4850263 apfD Actinobacillus pleuropneumoniae serovar 5b str. L20 fimbrial leader peptidase YP_001053578.1 1017372 R 416269 CDS YP_001053579.1 126208354 4848621 complement(1018037..1019239) 1 NC_009053.1 pubmed:14742510; fimbrial biogenesis protein 1019239 apfC 4848621 apfC Actinobacillus pleuropneumoniae serovar 5b str. L20 fimbrial biogenesis protein YP_001053579.1 1018037 R 416269 CDS YP_001053580.1 126208355 4849336 complement(1019223..1020617) 1 NC_009053.1 pubmed:14742510; fimbrial biogenesis protein 1020617 apfB 4849336 apfB Actinobacillus pleuropneumoniae serovar 5b str. L20 fimbrial biogenesis protein YP_001053580.1 1019223 R 416269 CDS YP_001053581.1 126208356 4849505 complement(1020635..1021081) 1 NC_009053.1 pubmed:14742510; type 4 prepilin subunit ApfA 1021081 apfA 4849505 apfA Actinobacillus pleuropneumoniae serovar 5b str. L20 type 4 prepilin subunit ApfA YP_001053581.1 1020635 R 416269 CDS YP_001053582.1 126208357 4850366 1021263..1022642 1 NC_009053.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents; DNA repair protein RadA 1022642 radA 4850366 radA Actinobacillus pleuropneumoniae serovar 5b str. L20 DNA repair protein RadA YP_001053582.1 1021263 D 416269 CDS YP_001053583.1 126208358 4849711 complement(1022686..1022919) 1 NC_009053.1 hypothetical protein 1022919 4849711 APL_0882 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053583.1 1022686 R 416269 CDS YP_001053584.1 126208359 4850244 complement(1023046..1023534) 1 NC_009053.1 dihydrofolate reductase 1023534 folA 4850244 folA Actinobacillus pleuropneumoniae serovar 5b str. L20 dihydrofolate reductase YP_001053584.1 1023046 R 416269 CDS YP_001053585.1 126208360 4850252 1023621..1024712 1 NC_009053.1 catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis; gamma-glutamyl kinase 1024712 proB 4850252 proB Actinobacillus pleuropneumoniae serovar 5b str. L20 gamma-glutamyl kinase YP_001053585.1 1023621 D 416269 CDS YP_001053586.1 126208361 4849341 1024725..1025501 1 NC_009053.1 hypothetical protein 1025501 4849341 APL_0885 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053586.1 1024725 D 416269 CDS YP_001053587.1 126208362 4849103 1025502..1026134 1 NC_009053.1 endonuclease III 1026134 nth 4849103 nth Actinobacillus pleuropneumoniae serovar 5b str. L20 endonuclease III YP_001053587.1 1025502 D 416269 CDS YP_001053588.1 126208363 4848975 1026344..1027648 1 NC_009053.1 3-ketoacyl-CoA thiolase 1027648 fadI 4848975 fadI Actinobacillus pleuropneumoniae serovar 5b str. L20 3-ketoacyl-CoA thiolase YP_001053588.1 1026344 D 416269 CDS YP_001053589.1 126208364 4849370 1027658..1029775 1 NC_009053.1 fatty acid oxidation complex subunit alpha 1029775 fadJ 4849370 fadJ Actinobacillus pleuropneumoniae serovar 5b str. L20 fatty acid oxidation complex subunit alpha YP_001053589.1 1027658 D 416269 CDS YP_001053590.1 126208365 4848552 1029866..1031281 1 NC_009053.1 hypothetical protein 1031281 4848552 APL_0889 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053590.1 1029866 D 416269 CDS YP_001053591.1 126208366 4848761 complement(1031364..1032296) 1 NC_009053.1 hypothetical protein 1032296 4848761 APL_0890 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053591.1 1031364 R 416269 CDS YP_001053592.1 126208367 4849981 complement(1032298..1033104) 1 NC_009053.1 formate dehydrogenase accessory protein-like protein 1033104 fdhD 4849981 fdhD Actinobacillus pleuropneumoniae serovar 5b str. L20 formate dehydrogenase accessory protein-like protein YP_001053592.1 1032298 R 416269 CDS YP_001053593.1 126208368 4850066 1033523..1034110 1 NC_009053.1 formate dehydrogenase, nitrate-inducible, major subunit 1034110 fdxG 4850066 fdxG Actinobacillus pleuropneumoniae serovar 5b str. L20 formate dehydrogenase, nitrate-inducible, major subunit YP_001053593.1 1033523 D 416269 CDS YP_001053594.1 126208369 4848642 1034159..1036582 1 NC_009053.1 formate dehydrogenase, nitrate-inducible, major subunit 1036582 fdxG 4848642 fdxG Actinobacillus pleuropneumoniae serovar 5b str. L20 formate dehydrogenase, nitrate-inducible, major subunit YP_001053594.1 1034159 D 416269 CDS YP_001053595.1 126208370 4848699 1036582..1037481 1 NC_009053.1 formate dehydrogenase, iron-sulfur subunit 1037481 fdxH 4848699 fdxH Actinobacillus pleuropneumoniae serovar 5b str. L20 formate dehydrogenase, iron-sulfur subunit YP_001053595.1 1036582 D 416269 CDS YP_001053596.1 126208371 4848527 1037474..1038145 1 NC_009053.1 formate dehydrogenase, cytochrome b556 subunit 1038145 fdnI 4848527 fdnI Actinobacillus pleuropneumoniae serovar 5b str. L20 formate dehydrogenase, cytochrome b556 subunit YP_001053596.1 1037474 D 416269 CDS YP_001053597.1 126208372 4849150 1038255..1039172 1 NC_009053.1 required for the formation of active formate dehydrogenase; formate dehydrogenase accessory protein FdhE 1039172 fdhE 4849150 fdhE Actinobacillus pleuropneumoniae serovar 5b str. L20 formate dehydrogenase accessory protein FdhE YP_001053597.1 1038255 D 416269 CDS YP_001053598.1 126208373 4850107 1039775..1040632 1 NC_009053.1 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate; bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase 1040632 folD 4850107 folD Actinobacillus pleuropneumoniae serovar 5b str. L20 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase YP_001053598.1 1039775 D 416269 CDS YP_001053599.1 126208374 4848687 1040777..1042315 1 NC_009053.1 oxalate/formate antiporter 1042315 4848687 APL_0898 Actinobacillus pleuropneumoniae serovar 5b str. L20 oxalate/formate antiporter YP_001053599.1 1040777 D 416269 CDS YP_001053600.1 126208375 4848494 complement(1042413..1043300) 1 NC_009053.1 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate synthase 1043300 dapA 4848494 dapA Actinobacillus pleuropneumoniae serovar 5b str. L20 dihydrodipicolinate synthase YP_001053600.1 1042413 R 416269 CDS YP_001053601.1 126208376 4850171 complement(1043459..1044400) 1 NC_009053.1 Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis lauroyl acyltransferase 1044400 lpxL 4850171 lpxL Actinobacillus pleuropneumoniae serovar 5b str. L20 lipid A biosynthesis lauroyl acyltransferase YP_001053601.1 1043459 R 416269 CDS YP_001053602.1 126208377 4848519 1044565..1044879 1 NC_009053.1 ribosome-associated inhibitor A 1044879 4848519 APL_0901 Actinobacillus pleuropneumoniae serovar 5b str. L20 ribosome-associated inhibitor A YP_001053602.1 1044565 D 416269 CDS YP_001053603.1 126208378 4850172 complement(1044938..1045726) 1 NC_009053.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability; tRNA pseudouridine synthase A 1045726 truA 4850172 truA Actinobacillus pleuropneumoniae serovar 5b str. L20 tRNA pseudouridine synthase A YP_001053603.1 1044938 R 416269 CDS YP_001053604.1 126208379 4850242 complement(1045805..1046461) 1 NC_009053.1 involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer; GTP cyclohydrolase I 1046461 folE 4850242 folE Actinobacillus pleuropneumoniae serovar 5b str. L20 GTP cyclohydrolase I YP_001053604.1 1045805 R 416269 CDS YP_001053605.1 126208380 4848656 1046562..1047266 1 NC_009053.1 catalyzes the phosphorylation of 3-deoxy-D-manno-octulosonic acid at the 4-OH position; 3-deoxy-D-manno-octulosonic-acid kinase 1047266 kdkA 4848656 kdkA Actinobacillus pleuropneumoniae serovar 5b str. L20 3-deoxy-D-manno-octulosonic-acid kinase YP_001053605.1 1046562 D 416269 CDS YP_001053606.1 126208381 4848731 complement(1047346..1047684) 1 NC_009053.1 hypothetical protein 1047684 4848731 APL_0905 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053606.1 1047346 R 416269 CDS YP_001053607.1 126208382 4849913 complement(1047743..1048318) 1 NC_009053.1 acetyltransferase 1048318 4849913 APL_0906 Actinobacillus pleuropneumoniae serovar 5b str. L20 acetyltransferase YP_001053607.1 1047743 R 416269 CDS YP_001053608.1 126208383 4849518 complement(1048403..1049545) 1 NC_009053.1 hypothetical protein 1049545 4849518 APL_0907 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053608.1 1048403 R 416269 CDS YP_001053609.1 126208384 4849854 1049704..1050588 1 NC_009053.1 transcriptional regulator 1050588 4849854 APL_0908 Actinobacillus pleuropneumoniae serovar 5b str. L20 transcriptional regulator YP_001053609.1 1049704 D 416269 CDS YP_001053610.1 126208385 4849928 complement(1050643..1051461) 1 NC_009053.1 outer membrane lipoprotein 2 1051461 plpB 4849928 plpB Actinobacillus pleuropneumoniae serovar 5b str. L20 outer membrane lipoprotein 2 YP_001053610.1 1050643 R 416269 CDS YP_001053611.1 126208386 4849722 complement(1051576..1052397) 1 NC_009053.1 outer membrane lipoprotein 1 1052397 plpA 4849722 plpA Actinobacillus pleuropneumoniae serovar 5b str. L20 outer membrane lipoprotein 1 YP_001053611.1 1051576 R 416269 CDS YP_001053612.1 126208387 4849613 complement(1052424..1053101) 1 NC_009053.1 D-methionine transport system permease protein MetI 1053101 metI 4849613 metI Actinobacillus pleuropneumoniae serovar 5b str. L20 D-methionine transport system permease protein MetI YP_001053612.1 1052424 R 416269 CDS YP_001053613.1 126208388 4848930 complement(1053091..1054125) 1 NC_009053.1 part of the metNIQ transport system for methionine; DL-methionine transporter ATP-binding subunit 1054125 metN 4848930 metN Actinobacillus pleuropneumoniae serovar 5b str. L20 DL-methionine transporter ATP-binding subunit YP_001053613.1 1053091 R 416269 CDS YP_001053614.1 126208389 4848686 complement(1054323..1055702) 1 NC_009053.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase 1055702 cysS 4848686 cysS Actinobacillus pleuropneumoniae serovar 5b str. L20 cysteinyl-tRNA synthetase YP_001053614.1 1054323 R 416269 CDS YP_001053615.1 126208390 4849798 1055847..1056356 1 NC_009053.1 peptidyl-prolyl cis-trans isomerase B 1056356 ppiB 4849798 ppiB Actinobacillus pleuropneumoniae serovar 5b str. L20 peptidyl-prolyl cis-trans isomerase B YP_001053615.1 1055847 D 416269 CDS YP_001053616.1 126208391 4850166 1056460..1057695 1 NC_009053.1 catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template; phosphohydrolase activities include hydrolysis of pyrophosphate, 5'-nucleoside tri- and diphosphates, NADP, and 2'-AMP with the production of Pi, metal-dependent phosphodiesterase activity for 2',3'-cAMP, 2',3'-cGMP, and 2',3'-cCMP, and hydrolysis 2',3'-cyclic substrates with the formation of 2'-nucleotides and 3'-nucleotides; these phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases; multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase 1057695 cca 4850166 cca Actinobacillus pleuropneumoniae serovar 5b str. L20 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase YP_001053616.1 1056460 D 416269 CDS YP_001053617.1 126208392 4848601 1057930..1058280 1 NC_009053.1 transposase 1058280 4848601 APL_0916 Actinobacillus pleuropneumoniae serovar 5b str. L20 transposase YP_001053617.1 1057930 D 416269 CDS YP_001053618.1 126208393 4849459 1058292..1058627 1 NC_009053.1 transposase 1058627 4849459 APL_0917 Actinobacillus pleuropneumoniae serovar 5b str. L20 transposase YP_001053618.1 1058292 D 416269 CDS YP_001053619.1 126208394 4849919 1058593..1058949 1 NC_009053.1 transposase 1058949 4849919 APL_0918 Actinobacillus pleuropneumoniae serovar 5b str. L20 transposase YP_001053619.1 1058593 D 416269 CDS YP_001053620.1 126208395 4849145 complement(1059147..1061495) 1 NC_009053.1 iron-regulated outer membrane protein 1061495 irp 4849145 irp Actinobacillus pleuropneumoniae serovar 5b str. L20 iron-regulated outer membrane protein YP_001053620.1 1059147 R 416269 CDS YP_001053621.1 126208396 4849991 1061681..1062937 1 NC_009053.1 hypothetical protein 1062937 4849991 APL_0920 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053621.1 1061681 D 416269 CDS YP_001053622.1 126208397 4848683 1062993..1064408 1 NC_009053.1 hypothetical protein 1064408 4848683 APL_0921 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053622.1 1062993 D 416269 CDS YP_001053623.1 126208398 4850484 complement(1064548..1065114) 1 NC_009053.1 hypothetical protein 1065114 4850484 APL_0922 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053623.1 1064548 R 416269 CDS YP_001053624.1 126208399 4849071 complement(1066530..1066724) 1 NC_009053.1 hypothetical protein 1066724 4849071 APL_0923 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053624.1 1066530 R 416269 CDS YP_001053625.1 126208400 4848661 complement(1066724..1067065) 1 NC_009053.1 2Fe-2S ferredoxin 1067065 fdx 4848661 fdx Actinobacillus pleuropneumoniae serovar 5b str. L20 2Fe-2S ferredoxin YP_001053625.1 1066724 R 416269 CDS YP_001053626.1 126208401 4849751 complement(1067186..1069039) 1 NC_009053.1 involved in the maturation of iron-sulfur cluster-containing proteins; chaperone protein HscA 1069039 hscA 4849751 hscA Actinobacillus pleuropneumoniae serovar 5b str. L20 chaperone protein HscA YP_001053626.1 1067186 R 416269 CDS YP_001053627.1 126208402 4850565 complement(1069158..1069790) 1 NC_009053.1 hypothetical protein 1069790 4850565 APL_0926 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053627.1 1069158 R 416269 CDS YP_001053628.1 126208403 4850380 complement(1069818..1070270) 1 NC_009053.1 hypothetical protein 1070270 4850380 APL_0927 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053628.1 1069818 R 416269 CDS YP_001053629.1 126208404 4849755 complement(1070318..1070839) 1 NC_009053.1 J-type co-chaperone that regulates the ATPase and peptide-binding activity of Hsc66 chaperone; may function in biogenesis of iron-sulfur proteins; co-chaperone HscB 1070839 hscB 4849755 hscB Actinobacillus pleuropneumoniae serovar 5b str. L20 co-chaperone HscB YP_001053629.1 1070318 R 416269 CDS YP_001053630.1 126208405 4850030 complement(1070849..1071172) 1 NC_009053.1 iron-binding protein IscA 1071172 iscA 4850030 iscA Actinobacillus pleuropneumoniae serovar 5b str. L20 iron-binding protein IscA YP_001053630.1 1070849 R 416269 CDS YP_001053631.1 126208406 4850192 complement(1071314..1071697) 1 NC_009053.1 scaffold protein 1071697 nifU 4850192 nifU Actinobacillus pleuropneumoniae serovar 5b str. L20 scaffold protein YP_001053631.1 1071314 R 416269 CDS YP_001053632.1 126208407 4849774 complement(1071830..1073056) 1 NC_009053.1 catalyzes the removal of elemental sulfur from cysteine to produce alanine; involved in NAD biosynthesis; cysteine desulfurase 1073056 iscS 4849774 iscS Actinobacillus pleuropneumoniae serovar 5b str. L20 cysteine desulfurase YP_001053632.1 1071830 R 416269 CDS YP_001053633.1 126208408 4849487 complement(1073111..1073563) 1 NC_009053.1 HTH-type transcriptional regulator 1073563 4849487 APL_0932 Actinobacillus pleuropneumoniae serovar 5b str. L20 HTH-type transcriptional regulator YP_001053633.1 1073111 R 416269 CDS YP_001053634.1 126208409 4848549 1074053..1075444 1 NC_009053.1 outer membrane protein 1075444 ompP1 4848549 ompP1 Actinobacillus pleuropneumoniae serovar 5b str. L20 outer membrane protein YP_001053634.1 1074053 D 416269 CDS YP_001053635.1 126208410 4848863 1075530..1076093 1 NC_009053.1 methylated DNA-protein cysteine methyltransferase 1076093 ogt 4848863 ogt Actinobacillus pleuropneumoniae serovar 5b str. L20 methylated DNA-protein cysteine methyltransferase YP_001053635.1 1075530 D 416269 CDS YP_001053636.1 126208411 4848563 complement(1076113..1077963) 1 NC_009053.1 aerobic respiration control sensor protein 1077963 4848563 APL_0935 Actinobacillus pleuropneumoniae serovar 5b str. L20 aerobic respiration control sensor protein YP_001053636.1 1076113 R 416269 CDS YP_001053637.1 126208412 4850288 complement(1078069..1078932) 1 NC_009053.1 hypothetical protein 1078932 4850288 APL_0936 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053637.1 1078069 R 416269 CDS YP_001053638.1 126208413 4850012 complement(1079048..1079590) 1 NC_009053.1 hypothetical protein 1079590 4850012 APL_0937 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053638.1 1079048 R 416269 CDS YP_001053639.1 126208414 4848856 complement(1079580..1080224) 1 NC_009053.1 DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium; dithiobiotin synthetase 1080224 bioD 4848856 bioD Actinobacillus pleuropneumoniae serovar 5b str. L20 dithiobiotin synthetase YP_001053639.1 1079580 R 416269 CDS YP_001053640.1 126208415 4850409 complement(1080224..1080994) 1 NC_009053.1 biotin synthesis protein 1080994 bioC 4850409 bioC Actinobacillus pleuropneumoniae serovar 5b str. L20 biotin synthesis protein YP_001053640.1 1080224 R 416269 CDS YP_001053641.1 126208416 4849890 complement(1080982..1081641) 1 NC_009053.1 hypothetical protein 1081641 4849890 APL_0940 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053641.1 1080982 R 416269 CDS YP_001053642.1 126208417 4848997 complement(1081651..1082814) 1 NC_009053.1 catalyzes the formation of 8-amino-7-oxononanoate from 6-carboxyhexanoyl-CoA and L-alanine; 8-amino-7-oxononanoate synthase 1082814 bioF 4848997 bioF Actinobacillus pleuropneumoniae serovar 5b str. L20 8-amino-7-oxononanoate synthase YP_001053642.1 1081651 R 416269 CDS YP_001053643.1 126208418 4849031 complement(1082841..1084139) 1 NC_009053.1 catalyzes the formation of S-adenosyl-4-methylthionine-2-oxobutanoate and 7,8-diaminononanoate from S-adenosyl-L-methionine and 8-amino-7-oxononanoate; adenosylmethionine-8-amino-7-oxononanoate aminotransferase 1084139 bioA 4849031 bioA Actinobacillus pleuropneumoniae serovar 5b str. L20 adenosylmethionine-8-amino-7-oxononanoate aminotransferase YP_001053643.1 1082841 R 416269 CDS YP_001053644.1 126208419 4849475 1084230..1085174 1 NC_009053.1 involved in methylation of ribosomal protein L3; N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase 1085174 4849475 APL_0943 Actinobacillus pleuropneumoniae serovar 5b str. L20 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase YP_001053644.1 1084230 D 416269 CDS YP_001053645.1 126208420 4849017 complement(1085256..1085732) 1 NC_009053.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreA 1085732 greA 4849017 greA Actinobacillus pleuropneumoniae serovar 5b str. L20 transcription elongation factor GreA YP_001053645.1 1085256 R 416269 CDS YP_001053646.1 126208421 4848609 1085816..1087258 1 NC_009053.1 penicillin binding protein 4; penicillin sensitive; catalyzes the formation of D-alanine from D-alanyl-D-alanine; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains; D-alanyl-D-alanine carboxypeptidase 1087258 dacB 4848609 dacB Actinobacillus pleuropneumoniae serovar 5b str. L20 D-alanyl-D-alanine carboxypeptidase YP_001053646.1 1085816 D 416269 CDS YP_001053647.1 126208422 4849030 complement(1087295..1087564) 1 NC_009053.1 hypothetical protein 1087564 4849030 APL_0946 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053647.1 1087295 R 416269 CDS YP_001053648.1 126208423 4850206 complement(1087883..1089004) 1 NC_009053.1 transposase 1089004 4850206 APL_0947 Actinobacillus pleuropneumoniae serovar 5b str. L20 transposase YP_001053648.1 1087883 R 416269 CDS YP_001053649.1 126208424 4850053 1089835..1090875 1 NC_009053.1 transposase 1090875 4850053 APL_0948 Actinobacillus pleuropneumoniae serovar 5b str. L20 transposase YP_001053649.1 1089835 D 416269 CDS YP_001053650.1 126208425 4849868 complement(1090914..1091474) 1 NC_009053.1 hypothetical protein 1091474 4849868 APL_0949 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053650.1 1090914 R 416269 CDS YP_001053651.1 126208426 4849602 complement(1091939..1092502) 1 NC_009053.1 hypothetical protein 1092502 4849602 APL_0950 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053651.1 1091939 R 416269 CDS YP_001053652.1 126208427 4850424 complement(1092656..1092964) 1 NC_009053.1 hypothetical protein 1092964 4850424 APL_0951 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053652.1 1092656 R 416269 CDS YP_001053653.1 126208428 4848736 1093033..1094115 1 NC_009053.1 transposase 1094115 4848736 APL_0952 Actinobacillus pleuropneumoniae serovar 5b str. L20 transposase YP_001053653.1 1093033 D 416269 CDS YP_001053654.1 126208429 4850483 1094115..1094549 1 NC_009053.1 hypothetical protein 1094549 4850483 APL_0953 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053654.1 1094115 D 416269 CDS YP_001053655.1 126208430 4848920 complement(1094550..1094939) 1 NC_009053.1 hypothetical protein 1094939 4848920 APL_0954 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053655.1 1094550 R 416269 CDS YP_001053656.1 126208431 4850184 complement(1094981..1095553) 1 NC_009053.1 leukotoxin translocation ATP-binding protein LktB (apxIIB) 1095553 apxIIB 4850184 apxIIB Actinobacillus pleuropneumoniae serovar 5b str. L20 leukotoxin translocation ATP-binding protein LktB (apxIIB) YP_001053656.1 1094981 R 416269 CDS YP_001053657.1 126208432 4848738 complement(1095618..1098488) 1 NC_009053.1 RTX-II toxin determinant A 1098488 apxIIA 4848738 apxIIA Actinobacillus pleuropneumoniae serovar 5b str. L20 RTX-II toxin determinant A YP_001053657.1 1095618 R 416269 CDS YP_001053658.1 126208433 4849786 complement(1099185..1100414) 1 NC_009053.1 hypothetical protein 1100414 4849786 APL_0957 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053658.1 1099185 R 416269 CDS YP_001053659.1 126208434 4849104 1100837..1102426 1 NC_009053.1 involved in de novo purine biosynthesis; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 1102426 purH 4849104 purH Actinobacillus pleuropneumoniae serovar 5b str. L20 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase YP_001053659.1 1100837 D 416269 CDS YP_001053660.1 126208435 4849498 complement(1104021..1111811) 1 NC_009053.1 hemagglutinin/hemolysin-like protein 1111811 4849498 APL_0959 Actinobacillus pleuropneumoniae serovar 5b str. L20 hemagglutinin/hemolysin-like protein YP_001053660.1 1104021 R 416269 CDS YP_001053661.1 126208436 4849645 complement(1113814..1116150) 1 NC_009053.1 determines N-hexane tolerance and is involved in outer membrane permeability; organic solvent tolerance protein 1116150 ostA 4849645 ostA Actinobacillus pleuropneumoniae serovar 5b str. L20 organic solvent tolerance protein YP_001053661.1 1113814 R 416269 CDS YP_001053662.1 126208437 4849323 complement(1116207..1117574) 1 NC_009053.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 1117574 hemN 4849323 hemN Actinobacillus pleuropneumoniae serovar 5b str. L20 coproporphyrinogen III oxidase YP_001053662.1 1116207 R 416269 CDS YP_001053663.1 126208438 4848926 complement(1117604..1118032) 1 NC_009053.1 hypothetical protein 1118032 4848926 APL_0964 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053663.1 1117604 R 416269 CDS YP_001053664.1 126208439 4849317 complement(1118087..1118665) 1 NC_009053.1 hypothetical protein 1118665 4849317 APL_0965 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053664.1 1118087 R 416269 CDS YP_001053665.1 126208440 4850175 complement(1118814..1120472) 1 NC_009053.1 hypothetical protein 1120472 4850175 APL_0966 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053665.1 1118814 R 416269 CDS YP_001053666.1 126208441 4849481 1120735..1121952 1 NC_009053.1 sodium/glutamate symport carrier protein 1121952 gltS 4849481 gltS Actinobacillus pleuropneumoniae serovar 5b str. L20 sodium/glutamate symport carrier protein YP_001053666.1 1120735 D 416269 CDS YP_001053667.1 126208442 4849974 complement(1122022..1122399) 1 NC_009053.1 hypothetical protein 1122399 4849974 APL_0968 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053667.1 1122022 R 416269 CDS YP_001053668.1 126208443 4848970 complement(1122496..1125375) 1 NC_009053.1 catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme; bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase 1125375 glnE 4848970 glnE Actinobacillus pleuropneumoniae serovar 5b str. L20 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase YP_001053668.1 1122496 R 416269 CDS YP_001053669.1 126208444 4848881 complement(1125450..1125716) 1 NC_009053.1 hypothetical protein 1125716 4848881 APL_0970 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053669.1 1125450 R 416269 CDS YP_001053670.1 126208445 4849942 complement(1125743..1126234) 1 NC_009053.1 acyl CoA thioester hydrolase 1126234 4849942 APL_0971 Actinobacillus pleuropneumoniae serovar 5b str. L20 acyl CoA thioester hydrolase YP_001053670.1 1125743 R 416269 CDS YP_001053671.1 126208446 4848571 complement(1126221..1126772) 1 NC_009053.1 Involved in cell division; probably involved in intracellular septation; intracellular septation protein A 1126772 ispZ 4848571 ispZ Actinobacillus pleuropneumoniae serovar 5b str. L20 intracellular septation protein A YP_001053671.1 1126221 R 416269 CDS YP_001053672.1 126208447 4849246 complement(1126774..1127511) 1 NC_009053.1 hypothetical protein 1127511 4849246 APL_0973 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053672.1 1126774 R 416269 CDS YP_001053673.1 126208448 4849118 1127670..1128104 1 NC_009053.1 hypothetical protein 1128104 4849118 APL_0974 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053673.1 1127670 D 416269 CDS YP_001053674.1 126208449 4848931 1128272..1129228 1 NC_009053.1 TtcA; YdaO; catalyzes the thiolation of cytosine 32 in specific tRNAs; C32 tRNA thiolase 1129228 4848931 APL_0975 Actinobacillus pleuropneumoniae serovar 5b str. L20 C32 tRNA thiolase YP_001053674.1 1128272 D 416269 CDS YP_001053675.1 126208450 4850083 1129435..1130811 1 NC_009053.1 hypothetical protein 1130811 4850083 APL_0976 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053675.1 1129435 D 416269 CDS YP_001053676.1 126208451 4849520 1130902..1131705 1 NC_009053.1 removes the damaged DNA at cytosines and guanines by cleaving on the 3' side of the AP site by a beta-elimination reaction; exonuclease III 1131705 xthA 4849520 xthA Actinobacillus pleuropneumoniae serovar 5b str. L20 exonuclease III YP_001053676.1 1130902 D 416269 CDS YP_001053677.1 126208452 4848812 complement(1131769..1132653) 1 NC_009053.1 participates in controlling several genes involved in isoleucine and valine biosynthesis; activates the transcription of the ilvC gene in the presence of acetolactate or acetohydroxybutyrate; DNA-binding transcriptional regulator IlvY 1132653 ilvY 4848812 ilvY Actinobacillus pleuropneumoniae serovar 5b str. L20 DNA-binding transcriptional regulator IlvY YP_001053677.1 1131769 R 416269 CDS YP_001053678.1 126208453 4849101 complement(1132654..1133694) 1 NC_009053.1 D-glycero-D-manno-heptosyl transferase 1133694 lbgB 4849101 lbgB Actinobacillus pleuropneumoniae serovar 5b str. L20 D-glycero-D-manno-heptosyl transferase YP_001053678.1 1132654 R 416269 CDS YP_001053679.1 126208454 4849398 complement(1133736..1134377) 1 NC_009053.1 LPS biosynthesis protein 1134377 lbgA 4849398 lbgA Actinobacillus pleuropneumoniae serovar 5b str. L20 LPS biosynthesis protein YP_001053679.1 1133736 R 416269 CDS YP_001053680.1 126208455 4850379 1134486..1135547 1 NC_009053.1 hypothetical protein 1135547 4850379 APL_0981 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053680.1 1134486 D 416269 CDS YP_001053681.1 126208456 4850269 complement(1135609..1135821) 1 NC_009053.1 RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 1135821 rpmE 4850269 rpmE Actinobacillus pleuropneumoniae serovar 5b str. L20 50S ribosomal protein L31 YP_001053681.1 1135609 R 416269 CDS YP_001053682.1 126208457 4849549 1136203..1138209 1 NC_009053.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase 1138209 tktA 4849549 tktA Actinobacillus pleuropneumoniae serovar 5b str. L20 transketolase YP_001053682.1 1136203 D 416269 CDS YP_001053683.1 126208458 4849653 1138339..1138848 1 NC_009053.1 transposase 1138848 4849653 APL_0984 Actinobacillus pleuropneumoniae serovar 5b str. L20 transposase YP_001053683.1 1138339 D 416269 CDS YP_001053684.1 126208459 4849725 1138860..1139195 1 NC_009053.1 transposase 1139195 4849725 APL_0985 Actinobacillus pleuropneumoniae serovar 5b str. L20 transposase YP_001053684.1 1138860 D 416269 CDS YP_001053685.1 126208460 4850475 1139161..1139670 1 NC_009053.1 transposase-like protein 1139670 4850475 APL_0986 Actinobacillus pleuropneumoniae serovar 5b str. L20 transposase-like protein YP_001053685.1 1139161 D 416269 CDS YP_001053686.1 126208461 4848844 complement(1139729..1141606) 1 NC_009053.1 molecular chaperone; heat shock protein 90 1141606 htpG 4848844 htpG Actinobacillus pleuropneumoniae serovar 5b str. L20 heat shock protein 90 YP_001053686.1 1139729 R 416269 CDS YP_001053687.1 126208462 4849862 1141834..1143360 1 NC_009053.1 catalase 1143360 hktE 4849862 hktE Actinobacillus pleuropneumoniae serovar 5b str. L20 catalase YP_001053687.1 1141834 D 416269 CDS YP_001053688.1 126208463 4848537 1143527..1143706 1 NC_009053.1 transposase 1143706 4848537 APL_0989 Actinobacillus pleuropneumoniae serovar 5b str. L20 transposase YP_001053688.1 1143527 D 416269 CDS YP_001053689.1 126208464 4850495 1143726..1144064 1 NC_009053.1 transposase 1144064 4850495 APL_0990 Actinobacillus pleuropneumoniae serovar 5b str. L20 transposase YP_001053689.1 1143726 D 416269 CDS YP_001053690.1 126208465 4848793 1144177..1145256 1 NC_009053.1 hypothetical protein 1145256 4848793 APL_0991 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053690.1 1144177 D 416269 CDS YP_001053691.1 126208466 4849859 1145469..1147739 1 NC_009053.1 Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 1147739 nrdA 4849859 nrdA Actinobacillus pleuropneumoniae serovar 5b str. L20 ribonucleotide-diphosphate reductase subunit alpha YP_001053691.1 1145469 D 416269 CDS YP_001053692.1 126208467 4849173 1148036..1149166 1 NC_009053.1 B2 or R2 protein; type 1a enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdA; ribonucleotide-diphosphate reductase subunit beta 1149166 nrdB 4849173 nrdB Actinobacillus pleuropneumoniae serovar 5b str. L20 ribonucleotide-diphosphate reductase subunit beta YP_001053692.1 1148036 D 416269 CDS YP_001053693.1 126208468 4849633 1149428..1150477 1 NC_009053.1 catalyzes the interconversion of UDP-galactose and galactose-1-P with UDP-galactose and glucose-1-P; galactose-1-phosphate uridylyltransferase 1150477 galT 4849633 galT Actinobacillus pleuropneumoniae serovar 5b str. L20 galactose-1-phosphate uridylyltransferase YP_001053693.1 1149428 D 416269 CDS YP_001053694.1 126208469 4848693 1150505..1151659 1 NC_009053.1 catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism; galactokinase 1151659 galK 4848693 galK Actinobacillus pleuropneumoniae serovar 5b str. L20 galactokinase YP_001053694.1 1150505 D 416269 CDS YP_001053695.1 126208470 4849904 1151717..1152685 1 NC_009053.1 aldose 1-epimerase 1152685 galM 4849904 galM Actinobacillus pleuropneumoniae serovar 5b str. L20 aldose 1-epimerase YP_001053695.1 1151717 D 416269 CDS YP_001053696.1 126208471 4850088 1152710..1155730 1 NC_009053.1 beta-galactosidase 1155730 lacZ 4850088 lacZ Actinobacillus pleuropneumoniae serovar 5b str. L20 beta-galactosidase YP_001053696.1 1152710 D 416269 CDS YP_001053697.1 126208472 4849889 complement(1155848..1161703) 1 NC_009053.1 pubmed:10463177; RTX toxin protein 1161703 apxIVA 4849889 apxIVA Actinobacillus pleuropneumoniae serovar 5b str. L20 RTX toxin protein YP_001053697.1 1155848 R 416269 CDS YP_001053698.1 126208473 4848942 complement(1161732..1162208) 1 NC_009053.1 hypothetical protein 1162208 4848942 APL_0999 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053698.1 1161732 R 416269 CDS YP_001053699.1 126208474 4848795 complement(1162405..1163502) 1 NC_009053.1 ATPase 1163502 mrp 4848795 mrp Actinobacillus pleuropneumoniae serovar 5b str. L20 ATPase YP_001053699.1 1162405 R 416269 CDS YP_001053700.1 126208475 4849908 complement(1163506..1165056) 1 NC_009053.1 binding protein 1165056 4849908 APL_1001 Actinobacillus pleuropneumoniae serovar 5b str. L20 binding protein YP_001053700.1 1163506 R 416269 CDS YP_001053701.1 126208476 4849353 complement(1165071..1165724) 1 NC_009053.1 hypothetical protein 1165724 4849353 APL_1002 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053701.1 1165071 R 416269 CDS YP_001053702.1 126208477 4848846 complement(1165846..1167723) 1 NC_009053.1 peptidyl-prolyl cis-trans isomerase D 1167723 ppiD 4848846 ppiD Actinobacillus pleuropneumoniae serovar 5b str. L20 peptidyl-prolyl cis-trans isomerase D YP_001053702.1 1165846 R 416269 CDS YP_001053703.1 126208478 4849110 1167952..1169265 1 NC_009053.1 Na(+)/H(+) exchanger beta-like protein 1169265 nhaP 4849110 nhaP Actinobacillus pleuropneumoniae serovar 5b str. L20 Na(+)/H(+) exchanger beta-like protein YP_001053703.1 1167952 D 416269 CDS YP_001053704.1 126208479 4850401 1169387..1169656 1 NC_009053.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence; 30S ribosomal protein S15 1169656 rpsO 4850401 rpsO Actinobacillus pleuropneumoniae serovar 5b str. L20 30S ribosomal protein S15 YP_001053704.1 1169387 D 416269 CDS YP_001053705.1 126208480 4849838 1169734..1170603 1 NC_009053.1 hypothetical protein 1170603 4849838 APL_1006 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053705.1 1169734 D 416269 CDS YP_001053706.1 126208481 4849551 complement(1170661..1171911) 1 NC_009053.1 HemY-like protein 1171911 hemY 4849551 hemY Actinobacillus pleuropneumoniae serovar 5b str. L20 HemY-like protein YP_001053706.1 1170661 R 416269 CDS YP_001053707.1 126208482 4848690 complement(1171923..1173263) 1 NC_009053.1 uroporphyrin-III C-methyltransferase 1173263 hemX 4848690 hemX Actinobacillus pleuropneumoniae serovar 5b str. L20 uroporphyrin-III C-methyltransferase YP_001053707.1 1171923 R 416269 CDS YP_001053708.1 126208483 4850081 complement(1173273..1174037) 1 NC_009053.1 uroporphyrinogen-III synthase 1174037 hemD 4850081 hemD Actinobacillus pleuropneumoniae serovar 5b str. L20 uroporphyrinogen-III synthase YP_001053708.1 1173273 R 416269 CDS YP_001053709.1 126208484 4849719 complement(1174046..1174975) 1 NC_009053.1 porphobilinogen deaminase 1174975 hemC 4849719 hemC Actinobacillus pleuropneumoniae serovar 5b str. L20 porphobilinogen deaminase YP_001053709.1 1174046 R 416269 CDS YP_001053710.1 126208485 4849056 1175244..1177859 1 NC_009053.1 Includes: Alcohol dehydrogenase; Acetaldehyde dehydrogenase; bifunctional acetaldehyde-CoA/alcohol dehydrogenase 1177859 adh2 4849056 adh2 Actinobacillus pleuropneumoniae serovar 5b str. L20 bifunctional acetaldehyde-CoA/alcohol dehydrogenase YP_001053710.1 1175244 D 416269 CDS YP_001053711.1 126208486 4849874 complement(1178033..1179676) 1 NC_009053.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth; chaperonin GroEL 1179676 groEL 4849874 groEL Actinobacillus pleuropneumoniae serovar 5b str. L20 chaperonin GroEL YP_001053711.1 1178033 R 416269 CDS YP_001053712.1 126208487 4848835 complement(1179740..1180030) 1 NC_009053.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring; co-chaperonin GroES 1180030 groES 4848835 groES Actinobacillus pleuropneumoniae serovar 5b str. L20 co-chaperonin GroES YP_001053712.1 1179740 R 416269 CDS YP_001053713.1 126208488 4850479 complement(1180242..1180964) 1 NC_009053.1 catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate; purine nucleoside phosphorylase 1180964 deoD 4850479 deoD Actinobacillus pleuropneumoniae serovar 5b str. L20 purine nucleoside phosphorylase YP_001053713.1 1180242 R 416269 CDS YP_001053714.1 126208489 4849634 complement(1181023..1181799) 1 NC_009053.1 catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate; deoxyribose-phosphate aldolase 1181799 deoC 4849634 deoC Actinobacillus pleuropneumoniae serovar 5b str. L20 deoxyribose-phosphate aldolase YP_001053714.1 1181023 R 416269 CDS YP_001053715.1 126208490 4848934 complement(1181936..1183204) 1 NC_009053.1 nucleoside transporter 1183204 4848934 APL_1016 Actinobacillus pleuropneumoniae serovar 5b str. L20 nucleoside transporter YP_001053715.1 1181936 R 416269 CDS YP_001053716.1 126208491 4849105 1183417..1184061 1 NC_009053.1 hypothetical protein 1184061 4849105 APL_1017 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053716.1 1183417 D 416269 CDS YP_001053717.1 126208492 4848777 complement(1184113..1184754) 1 NC_009053.1 catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate; keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase 1184754 eda 4848777 eda Actinobacillus pleuropneumoniae serovar 5b str. L20 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase YP_001053717.1 1184113 R 416269 CDS YP_001053718.1 126208493 4850106 complement(1184769..1185713) 1 NC_009053.1 2-dehydro-3-deoxygluconokinase 1185713 kdgK 4850106 kdgK Actinobacillus pleuropneumoniae serovar 5b str. L20 2-dehydro-3-deoxygluconokinase YP_001053718.1 1184769 R 416269 CDS YP_001053719.1 126208494 4849310 complement(1185726..1186316) 1 NC_009053.1 uronate isomerase 1186316 uxaC 4849310 uxaC Actinobacillus pleuropneumoniae serovar 5b str. L20 uronate isomerase YP_001053719.1 1185726 R 416269 CDS YP_001053720.1 126208495 4849794 1186618..1188096 1 NC_009053.1 alpha-glucosidase 2 1188096 4849794 APL_1021 Actinobacillus pleuropneumoniae serovar 5b str. L20 alpha-glucosidase 2 YP_001053720.1 1186618 D 416269 CDS YP_001053721.1 126208496 4849554 1188100..1188336 1 NC_009053.1 transcriptional regulator 1188336 4849554 APL_1022 Actinobacillus pleuropneumoniae serovar 5b str. L20 transcriptional regulator YP_001053721.1 1188100 D 416269 CDS YP_001053722.1 126208497 4849073 1188311..1188892 1 NC_009053.1 hypothetical protein 1188892 4849073 APL_1023 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053722.1 1188311 D 416269 CDS YP_001053723.1 126208498 4848824 1188983..1189489 1 NC_009053.1 peptide methionine sulfoxide reductase MsrA 1189489 4848824 APL_1024 Actinobacillus pleuropneumoniae serovar 5b str. L20 peptide methionine sulfoxide reductase MsrA YP_001053723.1 1188983 D 416269 CDS YP_001053724.1 126208499 4850305 complement(1189524..1190324) 1 NC_009053.1 glycosyl transferase 1190324 lsgF 4850305 lsgF Actinobacillus pleuropneumoniae serovar 5b str. L20 glycosyl transferase YP_001053724.1 1189524 R 416269 CDS YP_001053725.1 126208500 4848728 complement(1190324..1191205) 1 NC_009053.1 glycosyltransferase 1191205 4848728 APL_1026 Actinobacillus pleuropneumoniae serovar 5b str. L20 glycosyltransferase YP_001053725.1 1190324 R 416269 CDS YP_001053726.1 126208501 4850304 complement(1191198..1192397) 1 NC_009053.1 hypothetical protein 1192397 4850304 APL_1027 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053726.1 1191198 R 416269 CDS YP_001053727.1 126208502 4850037 complement(1192398..1193168) 1 NC_009053.1 glycosyltransferase 1193168 4850037 APL_1028 Actinobacillus pleuropneumoniae serovar 5b str. L20 glycosyltransferase YP_001053727.1 1192398 R 416269 CDS YP_001053728.1 126208503 4850061 complement(1193165..1194310) 1 NC_009053.1 hypothetical protein 1194310 4850061 APL_1029 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053728.1 1193165 R 416269 CDS YP_001053729.1 126208504 4849911 complement(1194351..1195316) 1 NC_009053.1 hypothetical protein 1195316 4849911 APL_1030 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053729.1 1194351 R 416269 CDS YP_001053730.1 126208505 4849160 1195472..1196212 1 NC_009053.1 hypothetical protein 1196212 4849160 APL_1031 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053730.1 1195472 D 416269 CDS YP_001053731.1 126208506 4849089 complement(1196311..1198527) 1 NC_009053.1 binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity; primosome assembly protein PriA 1198527 priA 4849089 priA Actinobacillus pleuropneumoniae serovar 5b str. L20 primosome assembly protein PriA YP_001053731.1 1196311 R 416269 CDS YP_001053732.1 126208507 4849636 complement(1198612..1199769) 1 NC_009053.1 Includes: Chorismate mutase; Prephenate dehydratase; P-protein 1199769 pheA 4849636 pheA Actinobacillus pleuropneumoniae serovar 5b str. L20 P-protein YP_001053732.1 1198612 R 416269 CDS YP_001053733.1 126208508 4848772 complement(1199892..1201925) 1 NC_009053.1 oligopeptidase A 1201925 prlC 4848772 prlC Actinobacillus pleuropneumoniae serovar 5b str. L20 oligopeptidase A YP_001053733.1 1199892 R 416269 CDS YP_001053734.1 126208509 4849949 complement(1202068..1202805) 1 NC_009053.1 activates pyruvate formate-lyase 1 under anaerobic conditions; pyruvate formate lyase-activating enzyme 1 1202805 pflA 4849949 pflA Actinobacillus pleuropneumoniae serovar 5b str. L20 pyruvate formate lyase-activating enzyme 1 YP_001053734.1 1202068 R 416269 CDS YP_001053735.1 126208510 4848607 complement(1202932..1205244) 1 NC_009053.1 formate acetyltransferase 1205244 pflB 4848607 pflB Actinobacillus pleuropneumoniae serovar 5b str. L20 formate acetyltransferase YP_001053735.1 1202932 R 416269 CDS YP_001053736.1 126208511 4849565 complement(1205337..1206161) 1 NC_009053.1 formate transporter 1206161 focA 4849565 focA Actinobacillus pleuropneumoniae serovar 5b str. L20 formate transporter YP_001053736.1 1205337 R 416269 CDS YP_001053737.1 126208512 4848677 1206365..1206847 1 NC_009053.1 hypothetical protein 1206847 4848677 APL_1038 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053737.1 1206365 D 416269 CDS YP_001053738.1 126208513 4850496 complement(1206907..1207776) 1 NC_009053.1 putative metalloprotease; heat shock protein HtpX 1207776 htpX 4850496 htpX Actinobacillus pleuropneumoniae serovar 5b str. L20 heat shock protein HtpX YP_001053738.1 1206907 R 416269 CDS YP_001053739.1 126208514 4848671 complement(1207863..1208933) 1 NC_009053.1 involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function; DNA polymerase IV 1208933 dinP 4848671 dinP Actinobacillus pleuropneumoniae serovar 5b str. L20 DNA polymerase IV YP_001053739.1 1207863 R 416269 CDS YP_001053740.1 126208515 4849256 1209040..1209948 1 NC_009053.1 hypothetical protein 1209948 4849256 APL_1041 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053740.1 1209040 D 416269 CDS YP_001053741.1 126208516 4848673 complement(1209987..1211267) 1 NC_009053.1 menaquinone-specific isochorismate synthase 1211267 menF 4848673 menF Actinobacillus pleuropneumoniae serovar 5b str. L20 menaquinone-specific isochorismate synthase YP_001053741.1 1209987 R 416269 CDS YP_001053742.1 126208517 4848497 1211431..1212648 1 NC_009053.1 broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor; aminotransferase AlaT 1212648 4848497 APL_1043 Actinobacillus pleuropneumoniae serovar 5b str. L20 aminotransferase AlaT YP_001053742.1 1211431 D 416269 CDS YP_001053743.1 126208518 4850183 1212692..1213585 1 NC_009053.1 hypothetical protein 1213585 4850183 APL_1044 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053743.1 1212692 D 416269 CDS YP_001053744.1 126208519 4848675 1213610..1214452 1 NC_009053.1 hypothetical protein 1214452 4848675 APL_1045 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053744.1 1213610 D 416269 CDS YP_001053745.1 126208520 4849107 1214449..1215066 1 NC_009053.1 lysine exporter protein 1215066 4849107 APL_1046 Actinobacillus pleuropneumoniae serovar 5b str. L20 lysine exporter protein YP_001053745.1 1214449 D 416269 CDS YP_001053746.1 126208521 4849777 complement(1215147..1217993) 1 NC_009053.1 hemoglobin-binding protein A 1217993 hgbA 4849777 hgbA Actinobacillus pleuropneumoniae serovar 5b str. L20 hemoglobin-binding protein A YP_001053746.1 1215147 R 416269 CDS YP_001053747.1 126208522 4850087 complement(1218053..1218574) 1 NC_009053.1 heme utilization protein 1218574 hugZ 4850087 hugZ Actinobacillus pleuropneumoniae serovar 5b str. L20 heme utilization protein YP_001053747.1 1218053 R 416269 CDS YP_001053748.1 126208523 4848676 complement(1219936..1220469) 1 NC_009053.1 disulfide bound formation protein DsbE 1220469 nrfX 4848676 nrfX Actinobacillus pleuropneumoniae serovar 5b str. L20 disulfide bound formation protein DsbE YP_001053748.1 1219936 R 416269 CDS YP_001053749.1 126208524 4849065 complement(1220471..1222387) 1 NC_009053.1 cytochrome c-type biogenesis protein NrfE 1222387 nrfE 4849065 nrfE Actinobacillus pleuropneumoniae serovar 5b str. L20 cytochrome c-type biogenesis protein NrfE YP_001053749.1 1220471 R 416269 CDS YP_001053750.1 126208525 4849469 complement(1222558..1224423) 1 NC_009053.1 glutathione-regulated potassium-efflux system protein 1224423 kefBC 4849469 kefBC Actinobacillus pleuropneumoniae serovar 5b str. L20 glutathione-regulated potassium-efflux system protein YP_001053750.1 1222558 R 416269 CDS YP_001053751.1 126208526 4848674 complement(1224512..1227040) 1 NC_009053.1 catalyzes transfer of adenylyl group of ATP from pyrophosphate to the 3'-hydroxyl group to form cyclic AMP; adenylate cyclase 1227040 cyaA 4848674 cyaA Actinobacillus pleuropneumoniae serovar 5b str. L20 adenylate cyclase YP_001053751.1 1224512 R 416269 CDS YP_001053752.1 126208527 4849232 1227296..1228516 1 NC_009053.1 FabB, beta-Ketoacyl-ACP synthase I, KASI; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-ACP synthase 1228516 fabB 4849232 fabB Actinobacillus pleuropneumoniae serovar 5b str. L20 3-oxoacyl-ACP synthase YP_001053752.1 1227296 D 416269 CDS YP_001053753.1 126208528 4848672 1228708..1229016 1 NC_009053.1 transposase 1229016 4848672 APL_1056 Actinobacillus pleuropneumoniae serovar 5b str. L20 transposase YP_001053753.1 1228708 D 416269 CDS YP_001053754.1 126208529 4849844 1229003..1229218 1 NC_009053.1 transposase 1229218 4849844 APL_1057 Actinobacillus pleuropneumoniae serovar 5b str. L20 transposase YP_001053754.1 1229003 D 416269 CDS YP_001053755.1 126208530 4849617 1229230..1229565 1 NC_009053.1 transposase 1229565 4849617 APL_1058 Actinobacillus pleuropneumoniae serovar 5b str. L20 transposase YP_001053755.1 1229230 D 416269 CDS YP_001053756.1 126208531 4848685 1229531..1230040 1 NC_009053.1 transposase-like protein 1230040 4848685 APL_1059 Actinobacillus pleuropneumoniae serovar 5b str. L20 transposase-like protein YP_001053756.1 1229531 D 416269 CDS YP_001053757.1 126208532 4848925 1230187..1230534 1 NC_009053.1 hypothetical protein 1230534 4848925 APL_1060 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053757.1 1230187 D 416269 CDS YP_001053758.1 126208533 4849916 1230590..1231186 1 NC_009053.1 hypothetical protein 1231186 4849916 APL_1061 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053758.1 1230590 D 416269 CDS YP_001053759.1 126208534 4848678 1231227..1231601 1 NC_009053.1 hypothetical protein 1231601 4848678 APL_1062 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053759.1 1231227 D 416269 CDS YP_001053760.1 126208535 4850302 1231690..1232355 1 NC_009053.1 transcriptional regulatory protein QseB 1232355 qseB 4850302 qseB Actinobacillus pleuropneumoniae serovar 5b str. L20 transcriptional regulatory protein QseB YP_001053760.1 1231690 D 416269 CDS YP_001053761.1 126208536 4848807 1232348..1233724 1 NC_009053.1 sensor protein QseC 1233724 qseC 4848807 qseC Actinobacillus pleuropneumoniae serovar 5b str. L20 sensor protein QseC YP_001053761.1 1232348 D 416269 CDS YP_001053762.1 126208537 4850256 complement(1233772..1234332) 1 NC_009053.1 hypothetical protein 1234332 4850256 APL_1065 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053762.1 1233772 R 416269 CDS YP_001053763.1 126208538 4850259 1234526..1234822 1 NC_009053.1 member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex; preprotein translocase subunit YajC 1234822 yajC 4850259 yajC Actinobacillus pleuropneumoniae serovar 5b str. L20 preprotein translocase subunit YajC YP_001053763.1 1234526 D 416269 CDS YP_001053764.2 162329625 4850482 1234849..1236696 1 NC_009053.1 part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; preprotein translocase subunit SecD 1236696 secD 4850482 secD Actinobacillus pleuropneumoniae serovar 5b str. L20 preprotein translocase subunit SecD YP_001053764.2 1234849 D 416269 CDS YP_001053765.1 126208540 4850039 1236707..1237681 1 NC_009053.1 forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF; preprotein translocase subunit SecF 1237681 secF 4850039 secF Actinobacillus pleuropneumoniae serovar 5b str. L20 preprotein translocase subunit SecF YP_001053765.1 1236707 D 416269 CDS YP_001053766.1 126208541 4849144 1237828..1238334 1 NC_009053.1 ferritin-like protein 1 1238334 ftnA 4849144 ftnA Actinobacillus pleuropneumoniae serovar 5b str. L20 ferritin-like protein 1 YP_001053766.1 1237828 D 416269 CDS YP_001053767.1 126208542 4849547 1238334..1238831 1 NC_009053.1 ferritin-like protein 2 1238831 ftnB 4849547 ftnB Actinobacillus pleuropneumoniae serovar 5b str. L20 ferritin-like protein 2 YP_001053767.1 1238334 D 416269 CDS YP_001053768.1 126208543 4850538 1239071..1240372 1 NC_009053.1 hypothetical protein 1240372 4850538 APL_1071 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053768.1 1239071 D 416269 CDS YP_001053769.1 126208544 4850536 complement(1240429..1241019) 1 NC_009053.1 Maf-like protein 1241019 4850536 APL_1072 Actinobacillus pleuropneumoniae serovar 5b str. L20 Maf-like protein YP_001053769.1 1240429 R 416269 CDS YP_001053770.1 126208545 4849114 1241175..1241717 1 NC_009053.1 hypothetical protein 1241717 4849114 APL_1073 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053770.1 1241175 D 416269 CDS YP_001053771.1 126208546 4849557 complement(1241813..1243261) 1 NC_009053.1 Required for the synthesis of the thiazole moiety; thiamine biosynthesis protein ThiI 1243261 thiI 4849557 thiI Actinobacillus pleuropneumoniae serovar 5b str. L20 thiamine biosynthesis protein ThiI YP_001053771.1 1241813 R 416269 CDS YP_001053772.1 126208547 4850489 complement(1243448..1244746) 1 NC_009053.1 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis; adenylosuccinate synthetase 1244746 purA 4850489 purA Actinobacillus pleuropneumoniae serovar 5b str. L20 adenylosuccinate synthetase YP_001053772.1 1243448 R 416269 CDS YP_001053773.1 126208548 4850537 complement(1244933..1245820) 1 NC_009053.1 protein HflC 1245820 hflC 4850537 hflC Actinobacillus pleuropneumoniae serovar 5b str. L20 protein HflC YP_001053773.1 1244933 R 416269 CDS YP_001053774.1 126208549 4848945 complement(1245823..1247013) 1 NC_009053.1 protein HflK 1247013 hflK 4848945 hflK Actinobacillus pleuropneumoniae serovar 5b str. L20 protein HflK YP_001053774.1 1245823 R 416269 CDS YP_001053775.1 126208550 4849716 complement(1247188..1247505) 1 NC_009053.1 thioredoxin 1247505 trxA 4849716 trxA Actinobacillus pleuropneumoniae serovar 5b str. L20 thioredoxin YP_001053775.1 1247188 R 416269 CDS YP_001053776.1 126208551 4848848 complement(1247641..1248933) 1 NC_009053.1 purine permease 1248933 4848848 APL_1079 Actinobacillus pleuropneumoniae serovar 5b str. L20 purine permease YP_001053776.1 1247641 R 416269 CDS YP_001053777.1 126208552 4850527 complement(1249095..1250246) 1 NC_009053.1 catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase; S-adenosylmethionine synthetase 1250246 metK 4850527 metK Actinobacillus pleuropneumoniae serovar 5b str. L20 S-adenosylmethionine synthetase YP_001053777.1 1249095 R 416269 CDS YP_001053778.1 126208553 4849266 1250466..1251359 1 NC_009053.1 homocysteine/selenocysteine methylase 1251359 4849266 APL_1081 Actinobacillus pleuropneumoniae serovar 5b str. L20 homocysteine/selenocysteine methylase YP_001053778.1 1250466 D 416269 CDS YP_001053779.1 126208554 4849750 1251451..1252866 1 NC_009053.1 arginine/ornithine antiporter 1252866 arcD 4849750 arcD Actinobacillus pleuropneumoniae serovar 5b str. L20 arginine/ornithine antiporter YP_001053779.1 1251451 D 416269 CDS YP_001053780.1 126208555 4849791 1252962..1254368 1 NC_009053.1 arginine/ornithine antiporter 1254368 arcD 4849791 arcD Actinobacillus pleuropneumoniae serovar 5b str. L20 arginine/ornithine antiporter YP_001053780.1 1252962 D 416269 CDS YP_001053781.1 126208556 4849537 1254377..1255156 1 NC_009053.1 hypothetical protein 1255156 4849537 APL_1084 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053781.1 1254377 D 416269 CDS YP_001053782.1 126208557 4849223 1255171..1256313 1 NC_009053.1 catalyzes the formation of L-ornithine from N(2)-acetyl-L-ornithine in arginine biosynthesis; acetylornithine deacetylase 1256313 argE 4849223 argE Actinobacillus pleuropneumoniae serovar 5b str. L20 acetylornithine deacetylase YP_001053782.1 1255171 D 416269 CDS YP_001053783.1 126208558 4848880 complement(1256394..1257041) 1 NC_009053.1 outer membrane protein W 1257041 ompW 4848880 ompW Actinobacillus pleuropneumoniae serovar 5b str. L20 outer membrane protein W YP_001053783.1 1256394 R 416269 CDS YP_001053784.1 126208559 4850133 1257302..1259875 1 NC_009053.1 chaperone ClpB 1259875 clpB 4850133 clpB Actinobacillus pleuropneumoniae serovar 5b str. L20 chaperone ClpB YP_001053784.1 1257302 D 416269 CDS YP_001053785.1 126208560 4849476 complement(1259932..1260933) 1 NC_009053.1 hypothetical protein 1260933 4849476 APL_1088 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053785.1 1259932 R 416269 CDS YP_001053786.1 126208561 4850179 complement(1260945..1261349) 1 NC_009053.1 arsenate reductase 1261349 arsC 4850179 arsC Actinobacillus pleuropneumoniae serovar 5b str. L20 arsenate reductase YP_001053786.1 1260945 R 416269 CDS YP_001053787.1 126208562 4849422 complement(1261409..1261723) 1 NC_009053.1 transcriptional regulator 1261723 arsR 4849422 arsR Actinobacillus pleuropneumoniae serovar 5b str. L20 transcriptional regulator YP_001053787.1 1261409 R 416269 CDS YP_001053788.1 126208563 4850000 complement(1261851..1263278) 1 NC_009053.1 catalyzes the formation of fumarate from aspartate; aspartate ammonia-lyase 1263278 aspA 4850000 aspA Actinobacillus pleuropneumoniae serovar 5b str. L20 aspartate ammonia-lyase YP_001053788.1 1261851 R 416269 CDS YP_001053789.1 126208564 4849707 complement(1263419..1263700) 1 NC_009053.1 hypothetical protein 1263700 4849707 APL_1092 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053789.1 1263419 R 416269 CDS YP_001053790.1 126208565 4850159 complement(1263774..1264523) 1 NC_009053.1 hypothetical protein 1264523 4850159 APL_1093 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053790.1 1263774 R 416269 CDS YP_001053791.1 126208566 4849371 1264888..1266276 1 NC_009053.1 transcription regulator protein 1266276 4849371 APL_1094 Actinobacillus pleuropneumoniae serovar 5b str. L20 transcription regulator protein YP_001053791.1 1264888 D 416269 CDS YP_001053792.1 126208567 4850427 complement(1266330..1267367) 1 NC_009053.1 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis; phosphoribosylaminoimidazole synthetase 1267367 purM 4850427 purM Actinobacillus pleuropneumoniae serovar 5b str. L20 phosphoribosylaminoimidazole synthetase YP_001053792.1 1266330 R 416269 CDS YP_001053793.1 126208568 4849205 1267582..1268715 1 NC_009053.1 hypothetical protein 1268715 4849205 APL_1096 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053793.1 1267582 D 416269 CDS YP_001053794.1 126208569 4849631 1268863..1269531 1 NC_009053.1 queuosine biosynthesis protein QueC 1269531 queC 4849631 queC Actinobacillus pleuropneumoniae serovar 5b str. L20 queuosine biosynthesis protein QueC YP_001053794.1 1268863 D 416269 CDS YP_001053795.1 126208570 4849527 1269524..1269946 1 NC_009053.1 6-pyruvoyl tetrahydrobiopterin synthase 1269946 4849527 APL_1098 Actinobacillus pleuropneumoniae serovar 5b str. L20 6-pyruvoyl tetrahydrobiopterin synthase YP_001053795.1 1269524 D 416269 CDS YP_001053796.1 126208571 4849350 1270039..1270671 1 NC_009053.1 hypothetical protein 1270671 4849350 APL_1099 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053796.1 1270039 D 416269 CDS YP_001053797.1 126208572 4850049 complement(1270812..1271369) 1 NC_009053.1 hypothetical protein 1271369 4850049 APL_1100 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053797.1 1270812 R 416269 CDS YP_001053798.1 126208573 4848868 complement(1272039..1273538) 1 NC_009053.1 catalyzes the removal of N-terminal amino acids preferably leucine from various peptides; leucyl aminopeptidase 1273538 pepA 4848868 pepA Actinobacillus pleuropneumoniae serovar 5b str. L20 leucyl aminopeptidase YP_001053798.1 1272039 R 416269 CDS YP_001053799.1 126208574 4850437 1273906..1274721 1 NC_009053.1 hypothetical protein 1274721 4850437 APL_1102 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053799.1 1273906 D 416269 CDS YP_001053800.1 126208575 4849226 1274992..1276023 1 NC_009053.1 hypothetical protein 1276023 4849226 APL_1103 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053800.1 1274992 D 416269 CDS YP_001053801.1 126208576 4848783 1276024..1277106 1 NC_009053.1 hypothetical protein 1277106 4848783 APL_1104 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053801.1 1276024 D 416269 CDS YP_001053802.1 126208577 4850566 1277313..1280789 1 NC_009053.1 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase; DNA polymerase III subunit alpha 1280789 dnaE 4850566 dnaE Actinobacillus pleuropneumoniae serovar 5b str. L20 DNA polymerase III subunit alpha YP_001053802.1 1277313 D 416269 CDS YP_001053803.1 126208578 4850260 complement(1281666..1282847) 1 NC_009053.1 non-folate utilizing enzyme, catalyzes the production of beta-formyl glycinamide ribonucleotide from formate, ATP, and beta-GAR and a side reaction producing acetyl phosphate and ADP from acetate and ATP; involved in de novo purine biosynthesis; phosphoribosylglycinamide formyltransferase 2 1282847 purT 4850260 purT Actinobacillus pleuropneumoniae serovar 5b str. L20 phosphoribosylglycinamide formyltransferase 2 YP_001053803.1 1281666 R 416269 CDS YP_001053804.1 126208579 4849349 complement(1282970..1285444) 1 NC_009053.1 PlsB; catalyzes the formation of 1-acyl-sn-glycerol 3-phosphate by transfering the acyl moiety from acyl-CoA; glycerol-3-phosphate acyltransferase 1285444 plsB 4849349 plsB Actinobacillus pleuropneumoniae serovar 5b str. L20 glycerol-3-phosphate acyltransferase YP_001053804.1 1282970 R 416269 CDS YP_001053805.1 126208580 4849212 1285601..1286233 1 NC_009053.1 Represses a number of genes involved in the response to DNA damage; LexA repressor 1286233 lexA 4849212 lexA Actinobacillus pleuropneumoniae serovar 5b str. L20 LexA repressor YP_001053805.1 1285601 D 416269 CDS YP_001053806.1 126208581 4849156 1286293..1286973 1 NC_009053.1 MutH; Sequence-specific endonuclease that cleaves unmethylated GATC sequences during DNA repair; DNA mismatch repair protein 1286973 mutH 4849156 mutH Actinobacillus pleuropneumoniae serovar 5b str. L20 DNA mismatch repair protein YP_001053806.1 1286293 D 416269 CDS YP_001053807.1 126208582 4850561 1287059..1287790 1 NC_009053.1 hypothetical protein 1287790 4850561 APL_1110 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053807.1 1287059 D 416269 CDS YP_001053808.1 126208583 4849180 1287905..1288942 1 NC_009053.1 hydrolyzes the terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides; beta-hexosaminidase 1288942 nagZ 4849180 nagZ Actinobacillus pleuropneumoniae serovar 5b str. L20 beta-hexosaminidase YP_001053808.1 1287905 D 416269 CDS YP_001053809.1 126208584 4848460 1289023..1290198 1 NC_009053.1 RNA uridine methyltransferase B; catalyzes the formation of 5-methyl-uridine at position 747 in 23S rRNA; 23S rRNA methyluridine methyltransferase 1290198 rumB 4848460 rumB Actinobacillus pleuropneumoniae serovar 5b str. L20 23S rRNA methyluridine methyltransferase YP_001053809.1 1289023 D 416269 CDS YP_001053810.1 126208585 4849738 1290405..1291715 1 NC_009053.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis; phosphopyruvate hydratase 1291715 eno 4849738 eno Actinobacillus pleuropneumoniae serovar 5b str. L20 phosphopyruvate hydratase YP_001053810.1 1290405 D 416269 CDS YP_001053811.1 126208586 4849249 1291740..1292420 1 NC_009053.1 hypothetical protein 1292420 4849249 APL_1114 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053811.1 1291740 D 416269 CDS YP_001053812.1 126208587 4850029 1292434..1292844 1 NC_009053.1 hypothetical protein 1292844 4850029 APL_1115 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053812.1 1292434 D 416269 CDS YP_001053813.1 126208588 4849458 complement(1292903..1294711) 1 NC_009053.1 ATP-dependent DNA helicase RecQ 1294711 recQ 4849458 recQ Actinobacillus pleuropneumoniae serovar 5b str. L20 ATP-dependent DNA helicase RecQ YP_001053813.1 1292903 R 416269 CDS YP_001053814.1 126208589 4850559 complement(1294796..1295101) 1 NC_009053.1 defects in the mitochondrial frataxin protein cause Friedreich ataxis which is an autosomal recessive neurodegenerative disease; based on phylogenomic distribution this protein may have a role in iron-sulfur cluster protein assembly; frataxin-like protein 1295101 cyaY 4850559 cyaY Actinobacillus pleuropneumoniae serovar 5b str. L20 frataxin-like protein YP_001053814.1 1294796 R 416269 CDS YP_001053815.1 126208590 4848639 complement(1295927..1296970) 1 NC_009053.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity; DNA-binding/iron metalloprotein/AP endonuclease 1296970 gcp 4848639 gcp Actinobacillus pleuropneumoniae serovar 5b str. L20 DNA-binding/iron metalloprotein/AP endonuclease YP_001053815.1 1295927 R 416269 CDS YP_001053816.1 126208591 4849816 complement(1297062..1297838) 1 NC_009053.1 lipoprotein 1297838 4849816 APL_1121 Actinobacillus pleuropneumoniae serovar 5b str. L20 lipoprotein YP_001053816.1 1297062 R 416269 CDS YP_001053817.1 126208592 4849280 1297991..1298968 1 NC_009053.1 responsible for synthesis of pseudouridine from uracil at positions 1911, 1915 and 1917 in 23S ribosomal RNA; 23S rRNA pseudouridine synthase D 1298968 rluD 4849280 rluD Actinobacillus pleuropneumoniae serovar 5b str. L20 23S rRNA pseudouridine synthase D YP_001053817.1 1297991 D 416269 CDS YP_001053818.1 126208593 4850459 complement(1299012..1299725) 1 NC_009053.1 hypothetical protein 1299725 4850459 APL_1123 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053818.1 1299012 R 416269 CDS YP_001053819.1 126208594 4849861 complement(1299786..1300760) 1 NC_009053.1 catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis; 6-phosphofructokinase 1300760 pfkA 4849861 pfkA Actinobacillus pleuropneumoniae serovar 5b str. L20 6-phosphofructokinase YP_001053819.1 1299786 R 416269 CDS YP_001053820.1 126208595 4848865 complement(1300870..1302072) 1 NC_009053.1 cysteine desulfurase 1302072 4848865 APL_1125 Actinobacillus pleuropneumoniae serovar 5b str. L20 cysteine desulfurase YP_001053820.1 1300870 R 416269 CDS YP_001053821.1 126208596 4849195 complement(1302072..1302770) 1 NC_009053.1 micrococcal nuclease (thermonuclease)-like protein 1302770 4849195 APL_1126 Actinobacillus pleuropneumoniae serovar 5b str. L20 micrococcal nuclease (thermonuclease)-like protein YP_001053821.1 1302072 R 416269 CDS YP_001053822.1 126208597 4850110 complement(1302836..1304203) 1 NC_009053.1 Na+/alanine symporter 1304203 4850110 APL_1127 Actinobacillus pleuropneumoniae serovar 5b str. L20 Na+/alanine symporter YP_001053822.1 1302836 R 416269 CDS YP_001053823.1 126208598 4850386 complement(1304670..1305722) 1 NC_009053.1 membrane protein 1305722 4850386 APL_1128 Actinobacillus pleuropneumoniae serovar 5b str. L20 membrane protein YP_001053823.1 1304670 R 416269 CDS YP_001053824.1 126208599 4849999 complement(1305816..1306190) 1 NC_009053.1 hypothetical protein 1306190 4849999 APL_1129 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053824.1 1305816 R 416269 CDS YP_001053825.1 126208600 4849878 1306339..1307736 1 NC_009053.1 protease 1307736 4849878 APL_1130 Actinobacillus pleuropneumoniae serovar 5b str. L20 protease YP_001053825.1 1306339 D 416269 CDS YP_001053826.1 126208601 4849203 1307881..1309230 1 NC_009053.1 hypothetical protein 1309230 4849203 APL_1131 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053826.1 1307881 D 416269 CDS YP_001053827.1 126208602 4850395 1309230..1310510 1 NC_009053.1 catalyzes the transfer of 2-keto-3-deoxy-D-manno-octulosonic acid to lipid A; 3-deoxy-D-manno-octulosonic-acid transferase 1310510 kdtA 4850395 kdtA Actinobacillus pleuropneumoniae serovar 5b str. L20 3-deoxy-D-manno-octulosonic-acid transferase YP_001053827.1 1309230 D 416269 CDS YP_001053828.1 126208603 4849508 1310512..1310988 1 NC_009053.1 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA; phosphopantetheine adenylyltransferase 1310988 coaD 4849508 coaD Actinobacillus pleuropneumoniae serovar 5b str. L20 phosphopantetheine adenylyltransferase YP_001053828.1 1310512 D 416269 CDS YP_001053829.1 126208604 4850534 1310991..1311545 1 NC_009053.1 3'-5' exoribonuclease specific for small oligoribonuclotides; oligoribonuclease 1311545 orn 4850534 orn Actinobacillus pleuropneumoniae serovar 5b str. L20 oligoribonuclease YP_001053829.1 1310991 D 416269 CDS YP_001053830.1 126208605 4850257 1311553..1312044 1 NC_009053.1 hypothetical protein 1312044 4850257 APL_1135 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053830.1 1311553 D 416269 CDS YP_001053831.1 126208606 4848706 1312068..1313213 1 NC_009053.1 N-acetylmuramoyl-L-alanine amidase AmiB precursor 1313213 amiB 4848706 amiB Actinobacillus pleuropneumoniae serovar 5b str. L20 N-acetylmuramoyl-L-alanine amidase AmiB precursor YP_001053831.1 1312068 D 416269 CDS YP_001053832.1 126208607 4849562 complement(1313292..1314932) 1 NC_009053.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; glucose-6-phosphate isomerase 1314932 pgi 4849562 pgi Actinobacillus pleuropneumoniae serovar 5b str. L20 glucose-6-phosphate isomerase YP_001053832.1 1313292 R 416269 CDS YP_001053833.1 126208608 4848670 complement(1314969..1315220) 1 NC_009053.1 hypothetical protein 1315220 4848670 APL_1138 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053833.1 1314969 R 416269 CDS YP_001053834.1 126208609 4849556 complement(1316031..1316855) 1 NC_009053.1 AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate; shikimate 5-dehydrogenase 1316855 aroE 4849556 aroE Actinobacillus pleuropneumoniae serovar 5b str. L20 shikimate 5-dehydrogenase YP_001053834.1 1316031 R 416269 CDS YP_001053835.1 126208610 4849072 complement(1316862..1317416) 1 NC_009053.1 hypothetical protein 1317416 4849072 APL_1140 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053835.1 1316862 R 416269 CDS YP_001053836.1 126208611 4848574 complement(1317939..1318247) 1 NC_009053.1 hypothetical protein 1318247 4848574 APL_1141 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053836.1 1317939 R 416269 CDS YP_001053837.1 126208612 4850002 complement(1318240..1318695) 1 NC_009053.1 binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities; recombination regulator RecX 1318695 recX 4850002 recX Actinobacillus pleuropneumoniae serovar 5b str. L20 recombination regulator RecX YP_001053837.1 1318240 R 416269 CDS YP_001053838.1 126208613 4848924 complement(1318766..1319896) 1 NC_009053.1 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs; recombinase A 1319896 recA 4848924 recA Actinobacillus pleuropneumoniae serovar 5b str. L20 recombinase A YP_001053838.1 1318766 R 416269 CDS YP_001053839.1 126208614 4849658 complement(1320010..1320600) 1 NC_009053.1 hypothetical protein 1320600 4849658 APL_1144 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053839.1 1320010 R 416269 CDS YP_001053840.1 126208615 4849472 complement(1320593..1321561) 1 NC_009053.1 catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine; para-aminobenzoate synthase component I 1321561 pabB 4849472 pabB Actinobacillus pleuropneumoniae serovar 5b str. L20 para-aminobenzoate synthase component I YP_001053840.1 1320593 R 416269 CDS YP_001053841.1 126208616 4848471 1321696..1323330 1 NC_009053.1 DNA recombination protein RmuC-like protein 1323330 rmuC 4848471 rmuC Actinobacillus pleuropneumoniae serovar 5b str. L20 DNA recombination protein RmuC-like protein YP_001053841.1 1321696 D 416269 CDS YP_001053842.1 126208617 4849035 1323314..1323898 1 NC_009053.1 catalyzes the formation of anthranilate from chorismate and glutamine; functions in tryptophan biosynthesis; anthranilate synthase component II 1323898 trpG 4849035 trpG Actinobacillus pleuropneumoniae serovar 5b str. L20 anthranilate synthase component II YP_001053842.1 1323314 D 416269 CDS YP_001053843.1 126208618 4848655 1324003..1324452 1 NC_009053.1 hypothetical protein 1324452 4848655 APL_1148 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053843.1 1324003 D 416269 CDS YP_001053844.1 126208619 4849850 1324625..1326400 1 NC_009053.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes; aspartyl-tRNA synthetase 1326400 aspS 4849850 aspS Actinobacillus pleuropneumoniae serovar 5b str. L20 aspartyl-tRNA synthetase YP_001053844.1 1324625 D 416269 CDS YP_001053845.1 126208620 4849943 1326434..1326904 1 NC_009053.1 converts dATP to dAMP and pyrophosphate; dATP pyrophosphohydrolase 1326904 ntpA 4849943 ntpA Actinobacillus pleuropneumoniae serovar 5b str. L20 dATP pyrophosphohydrolase YP_001053845.1 1326434 D 416269 CDS YP_001053846.1 126208621 4848794 1326928..1327668 1 NC_009053.1 hypothetical protein 1327668 4848794 APL_1151 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053846.1 1326928 D 416269 CDS YP_001053847.1 126208622 4848543 1327802..1328326 1 NC_009053.1 hypothetical protein 1328326 4848543 APL_1152 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053847.1 1327802 D 416269 CDS YP_001053848.1 126208623 4848696 1328410..1328988 1 NC_009053.1 endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity; Holliday junction resolvase 1328988 ruvC 4848696 ruvC Actinobacillus pleuropneumoniae serovar 5b str. L20 Holliday junction resolvase YP_001053848.1 1328410 D 416269 CDS YP_001053849.1 126208624 4848894 complement(1329028..1330542) 1 NC_009053.1 zinc protease 1330542 4848894 APL_1154 Actinobacillus pleuropneumoniae serovar 5b str. L20 zinc protease YP_001053849.1 1329028 R 416269 CDS YP_001053850.1 126208625 4849095 complement(1330700..1332973) 1 NC_009053.1 catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine; 5- methyltetrahydropteroyltriglutamate/homocysteine S-methyltransferase 1332973 metE 4849095 metE Actinobacillus pleuropneumoniae serovar 5b str. L20 5- methyltetrahydropteroyltriglutamate/homocysteine S-methyltransferase YP_001053850.1 1330700 R 416269 CDS YP_001053851.1 126208626 4849502 1334889..1335818 1 NC_009053.1 HTH-type transcriptional regulator MetR 1335818 metR 4849502 metR Actinobacillus pleuropneumoniae serovar 5b str. L20 HTH-type transcriptional regulator MetR YP_001053851.1 1334889 D 416269 CDS YP_001053852.1 126208627 4848624 complement(1335896..1336777) 1 NC_009053.1 hypothetical protein 1336777 4848624 APL_1159 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053852.1 1335896 R 416269 CDS YP_001053853.1 126208628 4849713 complement(1336910..1337959) 1 NC_009053.1 ribosomal large subunit pseudouridine synthase B 1337959 rluB 4849713 rluB Actinobacillus pleuropneumoniae serovar 5b str. L20 ribosomal large subunit pseudouridine synthase B YP_001053853.1 1336910 R 416269 CDS YP_001053854.1 126208629 4850104 complement(1338031..1338648) 1 NC_009053.1 hypothetical protein 1338648 4850104 APL_1161 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053854.1 1338031 R 416269 CDS YP_001053855.1 126208630 4849867 complement(1339192..1340088) 1 NC_009053.1 hypothetical protein 1340088 4849867 APL_1162 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053855.1 1339192 R 416269 CDS YP_001053856.1 126208631 4850422 1340248..1341798 1 NC_009053.1 with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine; anthranilate synthase component I 1341798 trpE 4850422 trpE Actinobacillus pleuropneumoniae serovar 5b str. L20 anthranilate synthase component I YP_001053856.1 1340248 D 416269 CDS YP_001053857.1 126208632 4849087 1341812..1342399 1 NC_009053.1 TrpG; with TrpE catalyzes the formation of anthranilate and glutamate from chorismate and glutamine; TrpG provides the glutamine amidotransferase activity; anthranilate synthase component II 1342399 trpG 4849087 trpG Actinobacillus pleuropneumoniae serovar 5b str. L20 anthranilate synthase component II YP_001053857.1 1341812 D 416269 CDS YP_001053858.1 126208633 4849521 1342456..1343460 1 NC_009053.1 Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate; anthranilate phosphoribosyltransferase 1343460 trpD 4849521 trpD Actinobacillus pleuropneumoniae serovar 5b str. L20 anthranilate phosphoribosyltransferase YP_001053858.1 1342456 D 416269 CDS YP_001053859.1 126208634 4849563 1343503..1344258 1 NC_009053.1 ubiquinone/menaquinone biosynthesis methyltransferase 1344258 4849563 APL_1166 Actinobacillus pleuropneumoniae serovar 5b str. L20 ubiquinone/menaquinone biosynthesis methyltransferase YP_001053859.1 1343503 D 416269 CDS YP_001053860.1 126208635 4848547 complement(1344285..1345370) 1 NC_009053.1 hypothetical protein 1345370 4848547 APL_1167 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053860.1 1344285 R 416269 CDS YP_001053861.1 126208636 4848499 1345566..1345781 1 NC_009053.1 hypothetical protein 1345781 4848499 APL_1168 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053861.1 1345566 D 416269 CDS YP_001053862.1 126208637 4848741 complement(1345870..1346319) 1 NC_009053.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk; 50S ribosomal protein L9 1346319 rplI 4848741 rplI Actinobacillus pleuropneumoniae serovar 5b str. L20 50S ribosomal protein L9 YP_001053862.1 1345870 R 416269 CDS YP_001053863.1 126208638 4849208 complement(1346539..1346913) 1 NC_009053.1 binds single-stranded DNA at the primosome assembly site; primosomal replication protein N 1346913 priB 4849208 priB Actinobacillus pleuropneumoniae serovar 5b str. L20 primosomal replication protein N YP_001053863.1 1346539 R 416269 CDS YP_001053864.1 126208639 4850541 complement(1346888..1347262) 1 NC_009053.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21; 30S ribosomal protein S6 1347262 rpsF 4850541 rpsF Actinobacillus pleuropneumoniae serovar 5b str. L20 30S ribosomal protein S6 YP_001053864.1 1346888 R 416269 CDS YP_001053865.1 126208640 4848787 1347552..1348838 1 NC_009053.1 catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis; phosphoribosylamine--glycine ligase 1348838 purD 4848787 purD Actinobacillus pleuropneumoniae serovar 5b str. L20 phosphoribosylamine--glycine ligase YP_001053865.1 1347552 D 416269 CDS YP_001053866.1 126208641 4849630 complement(1348930..1349622) 1 NC_009053.1 nicotinamide mononucleotide transporter 1349622 pnuC 4849630 pnuC Actinobacillus pleuropneumoniae serovar 5b str. L20 nicotinamide mononucleotide transporter YP_001053866.1 1348930 R 416269 CDS YP_001053867.1 126208642 4850398 complement(1349750..1350373) 1 NC_009053.1 hypothetical protein 1350373 4850398 APL_1174 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053867.1 1349750 R 416269 CDS YP_001053868.1 126208643 4850132 complement(1350389..1351630) 1 NC_009053.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG; histidyl-tRNA synthetase 1351630 hisS 4850132 hisS Actinobacillus pleuropneumoniae serovar 5b str. L20 histidyl-tRNA synthetase YP_001053868.1 1350389 R 416269 CDS YP_001053869.1 126208644 4848995 complement(1351788..1352900) 1 NC_009053.1 catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase 1352900 ispG 4848995 ispG Actinobacillus pleuropneumoniae serovar 5b str. L20 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase YP_001053869.1 1351788 R 416269 CDS YP_001053870.1 126208645 4850400 complement(1352910..1353878) 1 NC_009053.1 hypothetical protein 1353878 4850400 APL_1177 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053870.1 1352910 R 416269 CDS YP_001053871.1 126208646 4850220 1354158..1355714 1 NC_009053.1 integral membrane sulfate transporter 1355714 4850220 APL_1178 Actinobacillus pleuropneumoniae serovar 5b str. L20 integral membrane sulfate transporter YP_001053871.1 1354158 D 416269 CDS YP_001053872.1 126208647 4849954 complement(1356023..1357399) 1 NC_009053.1 catalyzes the formation of arginine from (N-L-arginino)succinate; argininosuccinate lyase 1357399 argH 4849954 argH Actinobacillus pleuropneumoniae serovar 5b str. L20 argininosuccinate lyase YP_001053872.1 1356023 R 416269 CDS YP_001053873.1 126208648 4849293 complement(1357682..1358725) 1 NC_009053.1 oxidoreductase 1358725 4849293 APL_1180 Actinobacillus pleuropneumoniae serovar 5b str. L20 oxidoreductase YP_001053873.1 1357682 R 416269 CDS YP_001053874.1 126208649 4849034 1358973..1360778 1 NC_009053.1 glutathione-regulated potassium-efflux system protein 1360778 kefB 4849034 kefB Actinobacillus pleuropneumoniae serovar 5b str. L20 glutathione-regulated potassium-efflux system protein YP_001053874.1 1358973 D 416269 CDS YP_001053875.1 126208650 4849079 1360973..1362181 1 NC_009053.1 hypothetical protein 1362181 4849079 APL_1182 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053875.1 1360973 D 416269 CDS YP_001053876.1 126208651 4849097 1362278..1363678 1 NC_009053.1 hypothetical protein 1363678 4849097 APL_1183 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053876.1 1362278 D 416269 CDS YP_001053877.1 126208652 4850057 1363681..1364178 1 NC_009053.1 hypothetical protein 1364178 4850057 APL_1184 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053877.1 1363681 D 416269 CDS YP_001053878.1 126208653 4850332 1364192..1364836 1 NC_009053.1 hypothetical protein 1364836 4850332 APL_1185 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053878.1 1364192 D 416269 CDS YP_001053879.1 126208654 4848754 complement(1365058..1365951) 1 NC_009053.1 transcriptional regulator 1365951 4848754 APL_1186 Actinobacillus pleuropneumoniae serovar 5b str. L20 transcriptional regulator YP_001053879.1 1365058 R 416269 CDS YP_001053880.1 126208655 4849360 1366076..1366528 1 NC_009053.1 hypothetical protein 1366528 4849360 APL_1187 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053880.1 1366076 D 416269 CDS YP_001053881.1 126208656 4849490 complement(1366651..1367283) 1 NC_009053.1 hypothetical protein 1367283 4849490 APL_1188 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053881.1 1366651 R 416269 CDS YP_001053882.1 126208657 4849491 1367935..1368357 1 NC_009053.1 hypothetical protein 1368357 4849491 APL_1189 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053882.1 1367935 D 416269 CDS YP_001053883.1 126208658 4849952 complement(1368533..1369432) 1 NC_009053.1 transcriptional regulator LysR-like protein 1369432 4849952 APL_1190 Actinobacillus pleuropneumoniae serovar 5b str. L20 transcriptional regulator LysR-like protein YP_001053883.1 1368533 R 416269 CDS YP_001053884.1 126208659 4850349 1369523..1370584 1 NC_009053.1 NADPH dehydrogenase 1370584 namA 4850349 namA Actinobacillus pleuropneumoniae serovar 5b str. L20 NADPH dehydrogenase YP_001053884.1 1369523 D 416269 CDS YP_001053885.1 126208660 4849005 1370654..1371703 1 NC_009053.1 hypothetical protein 1371703 4849005 APL_1192 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053885.1 1370654 D 416269 CDS YP_001053886.1 126208661 4850421 complement(1371916..1373130) 1 NC_009053.1 type I restriction-modification system, S subunit 1373130 4850421 APL_1193 Actinobacillus pleuropneumoniae serovar 5b str. L20 type I restriction-modification system, S subunit YP_001053886.1 1371916 R 416269 CDS YP_001053887.1 126208662 4849148 complement(1373145..1374797) 1 NC_009053.1 type I restriction-modification system, M subunit 1374797 4849148 APL_1194 Actinobacillus pleuropneumoniae serovar 5b str. L20 type I restriction-modification system, M subunit YP_001053887.1 1373145 R 416269 CDS YP_001053888.1 126208663 4850035 complement(1374794..1376674) 1 NC_009053.1 hypothetical protein 1376674 4850035 APL_1195 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053888.1 1374794 R 416269 CDS YP_001053889.1 126208664 4849306 complement(1376676..1379810) 1 NC_009053.1 type I restriction enzyme, R subunit 1379810 4849306 APL_1196 Actinobacillus pleuropneumoniae serovar 5b str. L20 type I restriction enzyme, R subunit YP_001053889.1 1376676 R 416269 CDS YP_001053890.1 126208665 4849522 complement(1379926..1380792) 1 NC_009053.1 3-hydroxyacid dehydrogenase 1380792 4849522 APL_1197 Actinobacillus pleuropneumoniae serovar 5b str. L20 3-hydroxyacid dehydrogenase YP_001053890.1 1379926 R 416269 CDS YP_001053891.1 126208666 4848834 1381046..1381708 1 NC_009053.1 NAD(P)H nitroreductase 1381708 4848834 APL_1198 Actinobacillus pleuropneumoniae serovar 5b str. L20 NAD(P)H nitroreductase YP_001053891.1 1381046 D 416269 CDS YP_001053892.1 126208667 4849840 1381862..1382479 1 NC_009053.1 hypothetical protein 1382479 4849840 APL_1199 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053892.1 1381862 D 416269 CDS YP_001053893.1 126208668 4849842 complement(1382582..1383007) 1 NC_009053.1 DNA mismatch endonuclease 1383007 4849842 APL_1200 Actinobacillus pleuropneumoniae serovar 5b str. L20 DNA mismatch endonuclease YP_001053893.1 1382582 R 416269 CDS YP_001053894.1 126208669 4848666 complement(1383014..1384675) 1 NC_009053.1 hypothetical protein 1384675 4848666 APL_1201 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053894.1 1383014 R 416269 CDS YP_001053895.1 126208670 4849693 complement(1384691..1385785) 1 NC_009053.1 modification methylase 1385785 4849693 APL_1202 Actinobacillus pleuropneumoniae serovar 5b str. L20 modification methylase YP_001053895.1 1384691 R 416269 CDS YP_001053896.1 126208671 4848742 1386211..1386774 1 NC_009053.1 hypothetical protein 1386774 4848742 APL_1203 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053896.1 1386211 D 416269 CDS YP_001053897.1 126208672 4849466 complement(1386848..1387705) 1 NC_009053.1 esterase 1387705 4849466 APL_1204 Actinobacillus pleuropneumoniae serovar 5b str. L20 esterase YP_001053897.1 1386848 R 416269 CDS YP_001053898.1 126208673 4849588 complement(1387841..1388524) 1 NC_009053.1 glutathione S-transferase 1388524 4849588 APL_1205 Actinobacillus pleuropneumoniae serovar 5b str. L20 glutathione S-transferase YP_001053898.1 1387841 R 416269 CDS YP_001053899.1 126208674 4849939 complement(1388658..1389077) 1 NC_009053.1 plasmid stability-like protein 1389077 4849939 APL_1206 Actinobacillus pleuropneumoniae serovar 5b str. L20 plasmid stability-like protein YP_001053899.1 1388658 R 416269 CDS YP_001053900.1 126208675 4848637 complement(1389087..1389344) 1 NC_009053.1 hypothetical protein 1389344 4848637 APL_1207 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053900.1 1389087 R 416269 CDS YP_001053901.1 126208676 4850185 complement(1389494..1390612) 1 NC_009053.1 alcohol dehydrogenase class 3 1390612 adhC 4850185 adhC Actinobacillus pleuropneumoniae serovar 5b str. L20 alcohol dehydrogenase class 3 YP_001053901.1 1389494 R 416269 CDS YP_001053902.1 126208677 4850378 complement(1390767..1392794) 1 NC_009053.1 choline-glycine betaine transporter 1392794 betT 4850378 betT Actinobacillus pleuropneumoniae serovar 5b str. L20 choline-glycine betaine transporter YP_001053902.1 1390767 R 416269 CDS YP_001053903.1 126208678 4850155 1393091..1393801 1 NC_009053.1 hypothetical protein 1393801 4850155 APL_1210 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053903.1 1393091 D 416269 CDS YP_001053904.1 126208679 4849106 1393801..1394637 1 NC_009053.1 hypothetical protein 1394637 4849106 APL_1211 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053904.1 1393801 D 416269 CDS YP_001053905.1 126208680 4849430 complement(1394716..1395663) 1 NC_009053.1 potassium-tellurite ethidium and proflavin transporter 1395663 tehA 4849430 tehA Actinobacillus pleuropneumoniae serovar 5b str. L20 potassium-tellurite ethidium and proflavin transporter YP_001053905.1 1394716 R 416269 CDS YP_001053906.1 126208681 4848638 complement(1395762..1396412) 1 NC_009053.1 hypothetical protein 1396412 4848638 APL_1213 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053906.1 1395762 R 416269 CDS YP_001053907.1 126208682 4850198 complement(1396650..1397213) 1 NC_009053.1 hypothetical protein 1397213 4850198 APL_1214 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053907.1 1396650 R 416269 CDS YP_001053908.1 126208683 4849642 complement(1397300..1399144) 1 NC_009053.1 ABC transporter ATP-binding protein 1399144 4849642 APL_1215 Actinobacillus pleuropneumoniae serovar 5b str. L20 ABC transporter ATP-binding protein YP_001053908.1 1397300 R 416269 CDS YP_001053909.1 126208684 4850390 complement(1399250..1399759) 1 NC_009053.1 catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2; S-ribosylhomocysteinase 1399759 luxS 4850390 luxS Actinobacillus pleuropneumoniae serovar 5b str. L20 S-ribosylhomocysteinase YP_001053909.1 1399250 R 416269 CDS YP_001053910.1 126208685 4849465 complement(1399814..1402480) 1 NC_009053.1 hypothetical protein 1402480 4849465 APL_1217 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053910.1 1399814 R 416269 CDS YP_001053911.1 126208686 4848648 complement(1402628..1403077) 1 NC_009053.1 ferric uptake regulation protein 1403077 fur 4848648 fur Actinobacillus pleuropneumoniae serovar 5b str. L20 ferric uptake regulation protein YP_001053911.1 1402628 R 416269 CDS YP_001053912.1 126208687 4850414 complement(1403106..1403630) 1 NC_009053.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin FldA 1403630 fldA 4850414 fldA Actinobacillus pleuropneumoniae serovar 5b str. L20 flavodoxin FldA YP_001053912.1 1403106 R 416269 CDS YP_001053913.1 126208688 4848869 complement(1403652..1403945) 1 NC_009053.1 LexA regulated protein 1403945 4848869 APL_1220 Actinobacillus pleuropneumoniae serovar 5b str. L20 LexA regulated protein YP_001053913.1 1403652 R 416269 CDS YP_001053914.1 126208689 4849209 complement(1404145..1404621) 1 NC_009053.1 hypothetical protein 1404621 4849209 APL_1221 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053914.1 1404145 R 416269 CDS YP_001053915.1 126208690 4848720 1404705..1405706 1 NC_009053.1 catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde; aspartate-semialdehyde dehydrogenase 1405706 4848720 APL_1222 Actinobacillus pleuropneumoniae serovar 5b str. L20 aspartate-semialdehyde dehydrogenase YP_001053915.1 1404705 D 416269 CDS YP_001053916.1 126208691 4849040 1405767..1407062 1 NC_009053.1 inner membrane protein 1407062 4849040 APL_1223 Actinobacillus pleuropneumoniae serovar 5b str. L20 inner membrane protein YP_001053916.1 1405767 D 416269 CDS YP_001053917.1 126208692 4848779 1407172..1407522 1 NC_009053.1 hypothetical protein 1407522 4848779 APL_1224 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053917.1 1407172 D 416269 CDS YP_001053918.1 126208693 4849721 1408957..1409745 1 NC_009053.1 hypothetical protein 1409745 4849721 APL_1227 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053918.1 1408957 D 416269 CDS YP_001053919.1 126208694 4848564 complement(1409885..1410103) 1 NC_009053.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3; translation initiation factor IF-1 1410103 infA 4848564 infA Actinobacillus pleuropneumoniae serovar 5b str. L20 translation initiation factor IF-1 YP_001053919.1 1409885 R 416269 CDS YP_001053920.1 126208695 4850329 complement(1410195..1410857) 1 NC_009053.1 AphA-like protein 1410857 aphA 4850329 aphA Actinobacillus pleuropneumoniae serovar 5b str. L20 AphA-like protein YP_001053920.1 1410195 R 416269 CDS YP_001053921.1 126208696 4849887 1410957..1411817 1 NC_009053.1 phosphoserine phosphatase 1411817 serB 4849887 serB Actinobacillus pleuropneumoniae serovar 5b str. L20 phosphoserine phosphatase YP_001053921.1 1410957 D 416269 CDS YP_001053922.1 126208697 4850480 1411876..1412367 1 NC_009053.1 putative nucleotide binding property based on structural studies of Haemophilus influenzae crystallized protein in PDB Accession Number 1IN0 and NMR studies of Escherichia coli YajQ; the YajQ protein from Pseudomonas synringae appears to play a role in activation of bateriophage phi6 segment L transcription; nucleotide-binding protein 1412367 4850480 APL_1231 Actinobacillus pleuropneumoniae serovar 5b str. L20 nucleotide-binding protein YP_001053922.1 1411876 D 416269 CDS YP_001053923.1 126208698 4849754 1412721..1415120 1 NC_009053.1 maltodextrin phosphorylase 1415120 malP 4849754 malP Actinobacillus pleuropneumoniae serovar 5b str. L20 maltodextrin phosphorylase YP_001053923.1 1412721 D 416269 CDS YP_001053924.1 126208699 4849638 complement(1415184..1417901) 1 NC_009053.1 HTH-type transcriptional regulator MalT 1417901 malT 4849638 malT Actinobacillus pleuropneumoniae serovar 5b str. L20 HTH-type transcriptional regulator MalT YP_001053924.1 1415184 R 416269 CDS YP_001053925.1 126208700 4849331 complement(1418016..1418900) 1 NC_009053.1 maltose regulon periplasmic protein 1418900 4849331 APL_1234 Actinobacillus pleuropneumoniae serovar 5b str. L20 maltose regulon periplasmic protein YP_001053925.1 1418016 R 416269 CDS YP_001053926.1 126208701 4849936 complement(1418968..1420242) 1 NC_009053.1 porin involved in the transport of maltose and maltodextrins; maltoporin 1420242 lamB 4849936 lamB Actinobacillus pleuropneumoniae serovar 5b str. L20 maltoporin YP_001053926.1 1418968 R 416269 CDS YP_001053927.1 126208702 4850405 complement(1420312..1421451) 1 NC_009053.1 with malEFG is involved in import of maltose/maltodextrin; maltose/maltodextrin transporter ATP-binding protein 1421451 malK 4850405 malK Actinobacillus pleuropneumoniae serovar 5b str. L20 maltose/maltodextrin transporter ATP-binding protein YP_001053927.1 1420312 R 416269 CDS YP_001053928.1 126208703 4849018 1421783..1422967 1 NC_009053.1 functions in the MalKFGE ABC transporter complex to transport maltose into the cell by using ATP hydrolysis; maltose ABC transporter periplasmic protein 1422967 malE 4849018 malE Actinobacillus pleuropneumoniae serovar 5b str. L20 maltose ABC transporter periplasmic protein YP_001053928.1 1421783 D 416269 CDS YP_001053929.1 126208704 4850103 1423046..1424596 1 NC_009053.1 with MalKGE is involved in maltose transport into the cell; maltose transporter membrane protein 1424596 malF 4850103 malF Actinobacillus pleuropneumoniae serovar 5b str. L20 maltose transporter membrane protein YP_001053929.1 1423046 D 416269 CDS YP_001053930.1 126208705 4849316 1424647..1425537 1 NC_009053.1 with MalKFE is involved in the transport of maltose into the cell; maltose transporter permease 1425537 malG 4849316 malG Actinobacillus pleuropneumoniae serovar 5b str. L20 maltose transporter permease YP_001053930.1 1424647 D 416269 CDS YP_001053931.1 126208706 4849684 1425628..1427646 1 NC_009053.1 amylomaltase; acts to release glucose from maltodextrins; 4-alpha-glucanotransferase 1427646 malQ 4849684 malQ Actinobacillus pleuropneumoniae serovar 5b str. L20 4-alpha-glucanotransferase YP_001053931.1 1425628 D 416269 CDS YP_001053932.1 126208707 4850492 1427864..1429450 1 NC_009053.1 hypothetical protein 1429450 4850492 APL_1241 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053932.1 1427864 D 416269 CDS YP_001053933.1 126208708 4848743 1429516..1430310 1 NC_009053.1 deoxyribonuclease 1430310 4848743 APL_1242 Actinobacillus pleuropneumoniae serovar 5b str. L20 deoxyribonuclease YP_001053933.1 1429516 D 416269 CDS YP_001053934.1 126208709 4850290 complement(1430369..1431739) 1 NC_009053.1 catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels of reduced glutathione in the cytosol; involved in redox regulation and oxidative defense; glutathione reductase 1431739 gor 4850290 gor Actinobacillus pleuropneumoniae serovar 5b str. L20 glutathione reductase YP_001053934.1 1430369 R 416269 CDS YP_001053935.1 126208710 4849647 1432223..1432834 1 NC_009053.1 hypothetical protein 1432834 4849647 APL_1244 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053935.1 1432223 D 416269 CDS YP_001053936.1 126208711 4849086 complement(1432923..1433441) 1 NC_009053.1 hypothetical protein 1433441 4849086 APL_1245 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053936.1 1432923 R 416269 CDS YP_001053937.1 126208712 4848993 complement(1433543..1434181) 1 NC_009053.1 hypothetical protein 1434181 4848993 APL_1246 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053937.1 1433543 R 416269 CDS YP_001053938.1 126208713 4850010 complement(1434344..1434637) 1 NC_009053.1 hypothetical protein 1434637 4850010 APL_1247 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053938.1 1434344 R 416269 CDS YP_001053939.1 126208714 4848542 complement(1434637..1435296) 1 NC_009053.1 AzlC family protein 1435296 4848542 APL_1248 Actinobacillus pleuropneumoniae serovar 5b str. L20 AzlC family protein YP_001053939.1 1434637 R 416269 CDS YP_001053940.1 126208715 4849165 complement(1435370..1436170) 1 NC_009053.1 peptide transport system ATP-binding protein SapF 1436170 sapF 4849165 sapF Actinobacillus pleuropneumoniae serovar 5b str. L20 peptide transport system ATP-binding protein SapF YP_001053940.1 1435370 R 416269 CDS YP_001053941.1 126208716 4849625 complement(1436286..1437362) 1 NC_009053.1 catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate; fructose-bisphosphate aldolase 1437362 fba 4849625 fba Actinobacillus pleuropneumoniae serovar 5b str. L20 fructose-bisphosphate aldolase YP_001053941.1 1436286 R 416269 CDS YP_001053942.1 126208717 4849213 complement(1437463..1438638) 1 NC_009053.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; phosphoglycerate kinase 1438638 pgk 4849213 pgk Actinobacillus pleuropneumoniae serovar 5b str. L20 phosphoglycerate kinase YP_001053942.1 1437463 R 416269 CDS YP_001053943.1 126208718 4848866 complement(1438796..1440184) 1 NC_009053.1 hypothetical protein 1440184 4848866 APL_1252 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053943.1 1438796 R 416269 CDS YP_001053944.1 126208719 4849583 complement(1440415..1441689) 1 NC_009053.1 sodium/sulfate transporter 1441689 4849583 APL_1253 Actinobacillus pleuropneumoniae serovar 5b str. L20 sodium/sulfate transporter YP_001053944.1 1440415 R 416269 CDS YP_001053945.1 126208720 4849820 complement(1441994..1443385) 1 NC_009053.1 hypothetical protein 1443385 4849820 APL_1254 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053945.1 1441994 R 416269 CDS YP_001053946.1 126208721 4848979 complement(1443581..1445494) 1 NC_009053.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit B 1445494 parE 4848979 parE Actinobacillus pleuropneumoniae serovar 5b str. L20 DNA topoisomerase IV subunit B YP_001053946.1 1443581 R 416269 CDS YP_001053947.1 126208722 4848760 complement(1445572..1446864) 1 NC_009053.1 phosphate regulon sensor protein PhoR 1446864 phoR 4848760 phoR Actinobacillus pleuropneumoniae serovar 5b str. L20 phosphate regulon sensor protein PhoR YP_001053947.1 1445572 R 416269 CDS YP_001053948.1 126208723 4849784 complement(1446864..1447505) 1 NC_009053.1 phosphate regulon transcriptional regulatory protein PhoB 1447505 phoB 4849784 phoB Actinobacillus pleuropneumoniae serovar 5b str. L20 phosphate regulon transcriptional regulatory protein PhoB YP_001053948.1 1446864 R 416269 CDS YP_001053949.1 126208724 4848884 complement(1447685..1448464) 1 NC_009053.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate transporter ATP-binding protein 1448464 pstB 4848884 pstB Actinobacillus pleuropneumoniae serovar 5b str. L20 phosphate transporter ATP-binding protein YP_001053949.1 1447685 R 416269 CDS YP_001053950.1 126208725 4849139 complement(1448473..1449324) 1 NC_009053.1 phosphate transport system permease protein PstA 1449324 pstA 4849139 pstA Actinobacillus pleuropneumoniae serovar 5b str. L20 phosphate transport system permease protein PstA YP_001053950.1 1448473 R 416269 CDS YP_001053951.1 126208726 4849351 complement(1449324..1450277) 1 NC_009053.1 phosphate transport system permease protein PstC 1450277 pstC 4849351 pstC Actinobacillus pleuropneumoniae serovar 5b str. L20 phosphate transport system permease protein PstC YP_001053951.1 1449324 R 416269 CDS YP_001053952.1 126208727 4849321 complement(1450428..1451471) 1 NC_009053.1 phosphate-binding periplasmic protein 1451471 pstS 4849321 pstS Actinobacillus pleuropneumoniae serovar 5b str. L20 phosphate-binding periplasmic protein YP_001053952.1 1450428 R 416269 CDS YP_001053953.1 126208728 4850441 complement(1451604..1451990) 1 NC_009053.1 MerR family transcriptional regulator 1451990 4850441 APL_1262 Actinobacillus pleuropneumoniae serovar 5b str. L20 MerR family transcriptional regulator YP_001053953.1 1451604 R 416269 CDS YP_001053954.1 126208729 4849953 1452076..1452528 1 NC_009053.1 hypothetical protein 1452528 4849953 APL_1263 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053954.1 1452076 D 416269 CDS YP_001053955.1 126208730 4849219 1452546..1452746 1 NC_009053.1 cation transport ATPase 1452746 4849219 APL_1264 Actinobacillus pleuropneumoniae serovar 5b str. L20 cation transport ATPase YP_001053955.1 1452546 D 416269 CDS YP_001053956.1 126208731 4850188 1452985..1455135 1 NC_009053.1 copper-transporting P-type ATPase 1455135 copA 4850188 copA Actinobacillus pleuropneumoniae serovar 5b str. L20 copper-transporting P-type ATPase YP_001053956.1 1452985 D 416269 CDS YP_001053957.1 126208732 4849375 complement(1455233..1456054) 1 NC_009053.1 dehydrogenase 1456054 4849375 APL_1266 Actinobacillus pleuropneumoniae serovar 5b str. L20 dehydrogenase YP_001053957.1 1455233 R 416269 CDS YP_001053958.1 126208733 4849285 complement(1456082..1456657) 1 NC_009053.1 hypothetical protein 1456657 4849285 APL_1267 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053958.1 1456082 R 416269 CDS YP_001053959.1 126208734 4849651 1456773..1458629 1 NC_009053.1 protease 4 1458629 sppA 4849651 sppA Actinobacillus pleuropneumoniae serovar 5b str. L20 protease 4 YP_001053959.1 1456773 D 416269 CDS YP_001053960.1 126208735 4848521 1458764..1459531 1 NC_009053.1 ribonuclease 1459531 4848521 APL_1269 Actinobacillus pleuropneumoniae serovar 5b str. L20 ribonuclease YP_001053960.1 1458764 D 416269 CDS YP_001053961.1 126208736 4849672 1459562..1460053 1 NC_009053.1 hypothetical protein 1460053 sprT 4849672 sprT Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053961.1 1459562 D 416269 CDS YP_001053962.1 126208737 4849539 1460158..1461444 1 NC_009053.1 NADH dehydrogenase 1461444 ndh 4849539 ndh Actinobacillus pleuropneumoniae serovar 5b str. L20 NADH dehydrogenase YP_001053962.1 1460158 D 416269 CDS YP_001053963.1 126208738 4849222 complement(1461636..1463975) 1 NC_009053.1 transcriptional accessory protein 1463975 4849222 APL_1272 Actinobacillus pleuropneumoniae serovar 5b str. L20 transcriptional accessory protein YP_001053963.1 1461636 R 416269 CDS YP_001053964.1 126208739 4849364 complement(1464050..1464598) 1 NC_009053.1 fimbrial biogenesis and twitching motility protein PilF-like protein 1464598 4849364 APL_1273 Actinobacillus pleuropneumoniae serovar 5b str. L20 fimbrial biogenesis and twitching motility protein PilF-like protein YP_001053964.1 1464050 R 416269 CDS YP_001053965.1 126208740 4850169 complement(1464652..1465833) 1 NC_009053.1 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance; ribosomal RNA large subunit methyltransferase N 1465833 4850169 APL_1274 Actinobacillus pleuropneumoniae serovar 5b str. L20 ribosomal RNA large subunit methyltransferase N YP_001053965.1 1464652 R 416269 CDS YP_001053966.1 126208741 4849358 1466737..1468176 1 NC_009053.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation; glutamyl-tRNA synthetase 1468176 gltX 4849358 gltX Actinobacillus pleuropneumoniae serovar 5b str. L20 glutamyl-tRNA synthetase YP_001053966.1 1466737 D 416269 CDS YP_001053967.1 126208742 4849757 1468514..1468765 1 NC_009053.1 Antitoxin that counteracts the effect of the YoeB toxin; antitoxin YefM 1468765 4849757 APL_1276 Actinobacillus pleuropneumoniae serovar 5b str. L20 antitoxin YefM YP_001053967.1 1468514 D 416269 CDS YP_001053968.1 126208743 4849171 complement(1469179..1469346) 1 NC_009053.1 hypothetical protein 1469346 4849171 APL_1277 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053968.1 1469179 R 416269 CDS YP_001053969.1 126208744 4848849 complement(1469348..1470328) 1 NC_009053.1 transfers the gamma-phosphate of ATP to the 4' position of a tetraacyldisaccharide 1-phosphate intermediate to form tetraacyldisaccharide 1,4'-bis-phosphate; tetraacyldisaccharide 4'-kinase 1470328 lpxK 4848849 lpxK Actinobacillus pleuropneumoniae serovar 5b str. L20 tetraacyldisaccharide 4'-kinase YP_001053969.1 1469348 R 416269 CDS YP_001053970.1 126208745 4849329 complement(1470422..1471681) 1 NC_009053.1 binds and unfolds substrates as part of the ClpXP protease; ATP-dependent protease ATP-binding subunit ClpX 1471681 clpX 4849329 clpX Actinobacillus pleuropneumoniae serovar 5b str. L20 ATP-dependent protease ATP-binding subunit ClpX YP_001053970.1 1470422 R 416269 CDS YP_001053971.1 126208746 4849909 complement(1471681..1472271) 1 NC_009053.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit 1472271 clpP 4849909 clpP Actinobacillus pleuropneumoniae serovar 5b str. L20 ATP-dependent Clp protease proteolytic subunit YP_001053971.1 1471681 R 416269 CDS YP_001053972.1 126208747 4850488 1472393..1472785 1 NC_009053.1 hypothetical protein 1472785 4850488 APL_1281 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053972.1 1472393 D 416269 CDS YP_001053973.1 126208748 4850481 complement(1473144..1473917) 1 NC_009053.1 DNA polymerase III subunit epsilon 1473917 dnaQ 4850481 dnaQ Actinobacillus pleuropneumoniae serovar 5b str. L20 DNA polymerase III subunit epsilon YP_001053973.1 1473144 R 416269 CDS YP_001053974.1 126208749 4848861 complement(1474004..1475674) 1 NC_009053.1 ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence; ABC transporter ATP-binding protein 1475674 4848861 APL_1283 Actinobacillus pleuropneumoniae serovar 5b str. L20 ABC transporter ATP-binding protein YP_001053974.1 1474004 R 416269 CDS YP_001053975.1 126208750 4849906 1475839..1476177 1 NC_009053.1 DNA-binding protein 1476177 4849906 APL_1284 Actinobacillus pleuropneumoniae serovar 5b str. L20 DNA-binding protein YP_001053975.1 1475839 D 416269 CDS YP_001053976.1 126208751 4848709 1476170..1476538 1 NC_009053.1 hypothetical protein 1476538 4848709 APL_1285 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053976.1 1476170 D 416269 CDS YP_001053977.1 126208752 4850469 complement(1477025..1478299) 1 NC_009053.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1478299 murA 4850469 murA Actinobacillus pleuropneumoniae serovar 5b str. L20 UDP-N-acetylglucosamine 1-carboxyvinyltransferase YP_001053977.1 1477025 R 416269 CDS YP_001053978.1 126208753 4848803 complement(1478431..1478691) 1 NC_009053.1 hypothetical protein 1478691 4848803 APL_1287 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053978.1 1478431 R 416269 CDS YP_001053979.1 126208754 4848651 complement(1478704..1479057) 1 NC_009053.1 hypothetical protein 1479057 4848651 APL_1288 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053979.1 1478704 R 416269 CDS YP_001053980.1 126208755 4849237 complement(1479067..1479705) 1 NC_009053.1 hypothetical protein 1479705 4849237 APL_1289 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053980.1 1479067 R 416269 CDS YP_001053981.1 126208756 4849248 complement(1479783..1480310) 1 NC_009053.1 hypothetical protein 1480310 4849248 APL_1290 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053981.1 1479783 R 416269 CDS YP_001053982.1 126208757 4850474 complement(1480329..1481033) 1 NC_009053.1 hypothetical protein 1481033 4850474 APL_1291 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053982.1 1480329 R 416269 CDS YP_001053983.1 126208758 4849921 complement(1481098..1481901) 1 NC_009053.1 ABC transporter ATP-binding protein 1481901 4849921 APL_1292 Actinobacillus pleuropneumoniae serovar 5b str. L20 ABC transporter ATP-binding protein YP_001053983.1 1481098 R 416269 CDS YP_001053984.1 126208759 4848722 1482162..1483556 1 NC_009053.1 periplasmic serine protease do/hhoA-like precursor 1483556 htrA 4848722 htrA Actinobacillus pleuropneumoniae serovar 5b str. L20 periplasmic serine protease do/hhoA-like precursor YP_001053984.1 1482162 D 416269 CDS YP_001053985.1 126208760 4850365 complement(1483595..1484482) 1 NC_009053.1 hypothetical protein 1484482 4850365 APL_1294 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053985.1 1483595 R 416269 CDS YP_001053986.1 126208761 4849304 complement(1484482..1484943) 1 NC_009053.1 regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes; arginine repressor 1484943 argR 4849304 argR Actinobacillus pleuropneumoniae serovar 5b str. L20 arginine repressor YP_001053986.1 1484482 R 416269 CDS YP_001053987.1 126208762 4850462 1485137..1486090 1 NC_009053.1 oxidizes malate to oxaloacetate; malate dehydrogenase 1486090 mdh 4850462 mdh Actinobacillus pleuropneumoniae serovar 5b str. L20 malate dehydrogenase YP_001053987.1 1485137 D 416269 CDS YP_001053988.1 126208763 4850268 1486180..1486449 1 NC_009053.1 hypothetical protein 1486449 4850268 APL_1297 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053988.1 1486180 D 416269 CDS YP_001053989.1 126208764 4849685 complement(1486517..1487161) 1 NC_009053.1 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP; adenylate kinase 1487161 adk 4849685 adk Actinobacillus pleuropneumoniae serovar 5b str. L20 adenylate kinase YP_001053989.1 1486517 R 416269 CDS YP_001053990.1 126208765 4849119 complement(1487313..1489436) 1 NC_009053.1 TonB dependent/ligand-gated channel 1489436 4849119 APL_1299 Actinobacillus pleuropneumoniae serovar 5b str. L20 TonB dependent/ligand-gated channel YP_001053990.1 1487313 R 416269 CDS YP_001053991.1 126208766 4849770 complement(1489613..1490893) 1 NC_009053.1 hypothetical protein 1490893 4849770 APL_1300 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053991.1 1489613 R 416269 CDS YP_001053992.1 126208767 4850058 complement(1491032..1492048) 1 NC_009053.1 UDP-glucose 4-epimerase 1492048 galE 4850058 galE Actinobacillus pleuropneumoniae serovar 5b str. L20 UDP-glucose 4-epimerase YP_001053992.1 1491032 R 416269 CDS YP_001053993.1 126208768 4849676 complement(1492112..1494163) 1 NC_009053.1 this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB; NAD-dependent DNA ligase LigA 1494163 ligA 4849676 ligA Actinobacillus pleuropneumoniae serovar 5b str. L20 NAD-dependent DNA ligase LigA YP_001053993.1 1492112 R 416269 CDS YP_001053994.1 126208769 4849591 complement(1494227..1495237) 1 NC_009053.1 interacts with cell division protein FitsZ and may be required to anchor septal ring structure; cell division protein ZipA 1495237 zipA 4849591 zipA Actinobacillus pleuropneumoniae serovar 5b str. L20 cell division protein ZipA YP_001053994.1 1494227 R 416269 CDS YP_001053995.1 126208770 4850451 1495357..1496238 1 NC_009053.1 putative role in sulfur assimilation; sulfate transport protein CysZ 1496238 cysZ 4850451 cysZ Actinobacillus pleuropneumoniae serovar 5b str. L20 sulfate transport protein CysZ YP_001053995.1 1495357 D 416269 CDS YP_001053996.1 126208771 4849467 complement(1496719..1498173) 1 NC_009053.1 catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate; 6-phosphogluconate dehydrogenase 1498173 gnd 4849467 gnd Actinobacillus pleuropneumoniae serovar 5b str. L20 6-phosphogluconate dehydrogenase YP_001053996.1 1496719 R 416269 CDS YP_001053997.1 126208772 4849413 complement(1498244..1498696) 1 NC_009053.1 hypothetical protein 1498696 4849413 APL_1306 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001053997.1 1498244 R 416269 CDS YP_001053998.1 126208773 4849801 complement(1499927..1501249) 1 NC_009053.1 permease 1501249 4849801 APL_1309 Actinobacillus pleuropneumoniae serovar 5b str. L20 permease YP_001053998.1 1499927 R 416269 CDS YP_001053999.1 126208774 4850258 complement(1501382..1502080) 1 NC_009053.1 6-phosphogluconolactonase 1502080 pgl 4850258 pgl Actinobacillus pleuropneumoniae serovar 5b str. L20 6-phosphogluconolactonase YP_001053999.1 1501382 R 416269 CDS YP_001054000.1 126208775 4849468 complement(1502152..1503639) 1 NC_009053.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate; glucose-6-phosphate 1-dehydrogenase 1503639 zwf 4849468 zwf Actinobacillus pleuropneumoniae serovar 5b str. L20 glucose-6-phosphate 1-dehydrogenase YP_001054000.1 1502152 R 416269 CDS YP_001054001.1 126208776 4849833 complement(1503711..1504526) 1 NC_009053.1 CysQ-like protein 1504526 cysQ 4849833 cysQ Actinobacillus pleuropneumoniae serovar 5b str. L20 CysQ-like protein YP_001054001.1 1503711 R 416269 CDS YP_001054002.1 126208777 4848464 complement(1504539..1505096) 1 NC_009053.1 ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose; ADP-ribose diphosphatase NudE 1505096 nudE 4848464 nudE Actinobacillus pleuropneumoniae serovar 5b str. L20 ADP-ribose diphosphatase NudE YP_001054002.1 1504539 R 416269 CDS YP_001054003.1 126208778 4850340 1505239..1505643 1 NC_009053.1 heat shock-like protein 15 1505643 hslR 4850340 hslR Actinobacillus pleuropneumoniae serovar 5b str. L20 heat shock-like protein 15 YP_001054003.1 1505239 D 416269 CDS YP_001054004.1 126208779 4849060 1505774..1506664 1 NC_009053.1 becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers; Hsp33-like chaperonin 1506664 hslO 4849060 hslO Actinobacillus pleuropneumoniae serovar 5b str. L20 Hsp33-like chaperonin YP_001054004.1 1505774 D 416269 CDS YP_001054005.1 126208780 4849204 complement(1506732..1508066) 1 NC_009053.1 functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to DcuA; DcuA and DcuB function as independent and mutually redundant C4-dicarboxylate (aspartate, malate, fumarate and succinate) transporters; anaerobic C4-dicarboxylate transporter 1508066 dcuB2 4849204 dcuB2 Actinobacillus pleuropneumoniae serovar 5b str. L20 anaerobic C4-dicarboxylate transporter YP_001054005.1 1506732 R 416269 CDS YP_001054006.1 126208781 4849194 1508919..1509923 1 NC_009053.1 ornithine carbamoyltransferase 1509923 arcB 4849194 arcB Actinobacillus pleuropneumoniae serovar 5b str. L20 ornithine carbamoyltransferase YP_001054006.1 1508919 D 416269 CDS YP_001054007.1 126208782 4849769 1509945..1510892 1 NC_009053.1 reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP; carbamate kinase 1510892 arcC 4849769 arcC Actinobacillus pleuropneumoniae serovar 5b str. L20 carbamate kinase YP_001054007.1 1509945 D 416269 CDS YP_001054008.1 126208783 4848682 complement(1511140..1512561) 1 NC_009053.1 Includes: Sucrose-specific phosphotransferase enzyme IIB component; Sucrose permease IIC component; PTS system sucrose-specific transporter subunit IIBC 1512561 ptsB 4848682 ptsB Actinobacillus pleuropneumoniae serovar 5b str. L20 PTS system sucrose-specific transporter subunit IIBC YP_001054008.1 1511140 R 416269 CDS YP_001054009.1 126208784 4849884 complement(1512752..1513396) 1 NC_009053.1 thiamine transport ATP-binding protein ThiQ 1513396 thiQ 4849884 thiQ Actinobacillus pleuropneumoniae serovar 5b str. L20 thiamine transport ATP-binding protein ThiQ YP_001054009.1 1512752 R 416269 CDS YP_001054010.1 126208785 4848892 complement(1513393..1515018) 1 NC_009053.1 permease; with TbpA and ThiQ functions in transport of thiamine and thiamine pyrophosphate into the cell; repressed in presence of exogenous thiamine; thiamine transporter membrane protein 1515018 thiP 4848892 thiP Actinobacillus pleuropneumoniae serovar 5b str. L20 thiamine transporter membrane protein YP_001054010.1 1513393 R 416269 CDS YP_001054011.1 126208786 4848616 1515255..1515512 1 NC_009053.1 PTS system phosphocarrier protein HPr 1515512 ptsH 4848616 ptsH Actinobacillus pleuropneumoniae serovar 5b str. L20 PTS system phosphocarrier protein HPr YP_001054011.1 1515255 D 416269 CDS YP_001054012.1 126208787 4850041 1515636..1517357 1 NC_009053.1 Phosphotransferase system, enzyme I; transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein; part of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active-transport system; phosphoenolpyruvate-protein phosphotransferase 1517357 ptsI 4850041 ptsI Actinobacillus pleuropneumoniae serovar 5b str. L20 phosphoenolpyruvate-protein phosphotransferase YP_001054012.1 1515636 D 416269 CDS YP_001054013.1 126208788 4848523 1517442..1517942 1 NC_009053.1 functions in phosphoenolpyruvate-(PEP)-dependent phosphotransferase (PTS) system; functions in the transport and phosphorylation of glucose; PTS system glucose-specific transporter 1517942 crr 4848523 crr Actinobacillus pleuropneumoniae serovar 5b str. L20 PTS system glucose-specific transporter YP_001054013.1 1517442 D 416269 CDS YP_001054014.1 126208789 4850295 1518127..1519554 1 NC_009053.1 catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A); (dimethylallyl)adenosine tRNA methylthiotransferase 1519554 4850295 APL_1325 Actinobacillus pleuropneumoniae serovar 5b str. L20 (dimethylallyl)adenosine tRNA methylthiotransferase YP_001054014.1 1518127 D 416269 CDS YP_001054015.1 126208790 4850442 1519784..1521982 1 NC_009053.1 unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present; involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair.; DNA-dependent helicase II 1521982 uvrD 4850442 uvrD Actinobacillus pleuropneumoniae serovar 5b str. L20 DNA-dependent helicase II YP_001054015.1 1519784 D 416269 CDS YP_001054016.1 126208791 4850355 1522186..1522995 1 NC_009053.1 GTP hydrolase involved in nickel liganding into hydrogenases; hydrogenase nickel incorporation protein HypB 1522995 hypB 4850355 hypB Actinobacillus pleuropneumoniae serovar 5b str. L20 hydrogenase nickel incorporation protein HypB YP_001054016.1 1522186 D 416269 CDS YP_001054017.1 126208792 4849730 1523007..1524122 1 NC_009053.1 hydrogenase expression/formation protein HypD 1524122 hypD 4849730 hypD Actinobacillus pleuropneumoniae serovar 5b str. L20 hydrogenase expression/formation protein HypD YP_001054017.1 1523007 D 416269 CDS YP_001054018.1 126208793 4849877 1524124..1525137 1 NC_009053.1 hydrogenase isoenzymes formation protein HypE 1525137 hypE 4849877 hypE Actinobacillus pleuropneumoniae serovar 5b str. L20 hydrogenase isoenzymes formation protein HypE YP_001054018.1 1524124 D 416269 CDS YP_001054019.1 126208794 4848518 complement(1525217..1527502) 1 NC_009053.1 carbamoyltransferase HypF 1527502 hypF 4848518 hypF Actinobacillus pleuropneumoniae serovar 5b str. L20 carbamoyltransferase HypF YP_001054019.1 1525217 R 416269 CDS YP_001054020.1 126208795 4850165 1527737..1528879 1 NC_009053.1 involved in hydrogen uptake; hydrogenase 2 small subunit 1528879 hyaA 4850165 hyaA Actinobacillus pleuropneumoniae serovar 5b str. L20 hydrogenase 2 small subunit YP_001054020.1 1527737 D 416269 CDS YP_001054021.1 126208796 4849879 1528872..1529909 1 NC_009053.1 Fe-S ferrodoxin type component; participates in the periplasmic electron-transferring activity of hydrogenase 2; hydrogenase 2 protein HybA 1529909 hybA 4849879 hybA Actinobacillus pleuropneumoniae serovar 5b str. L20 hydrogenase 2 protein HybA YP_001054021.1 1528872 D 416269 CDS YP_001054022.1 126208797 4849386 1529902..1531083 1 NC_009053.1 HybB; cytochrome b subunit of the hydrogenase 2 enzyme, composed of HybA, B, C, and O subunits; hydrogenase 2 b cytochrome subunit 1531083 hybB 4849386 hybB Actinobacillus pleuropneumoniae serovar 5b str. L20 hydrogenase 2 b cytochrome subunit YP_001054022.1 1529902 D 416269 CDS YP_001054023.1 126208798 4849682 1531080..1532789 1 NC_009053.1 involved in hydrogen uptake; hydrogenase 2 large subunit 1532789 hyaB 4849682 hyaB Actinobacillus pleuropneumoniae serovar 5b str. L20 hydrogenase 2 large subunit YP_001054023.1 1531080 D 416269 CDS YP_001054024.1 126208799 4849231 1532789..1533286 1 NC_009053.1 protease responsible for the cleavage of a 15 amino acid peptide from the C-terminal end of the large subunit of hydrogenase 2 (HybC); hydrogenase 2 maturation endopeptidase 1533286 hybD 4849231 hybD Actinobacillus pleuropneumoniae serovar 5b str. L20 hydrogenase 2 maturation endopeptidase YP_001054024.1 1532789 D 416269 CDS YP_001054025.1 126208800 4848718 1533279..1533782 1 NC_009053.1 hydrogenase 2-specific chaperone 1533782 hybE 4848718 hybE Actinobacillus pleuropneumoniae serovar 5b str. L20 hydrogenase 2-specific chaperone YP_001054025.1 1533279 D 416269 CDS YP_001054026.1 126208801 4850033 1533810..1534088 1 NC_009053.1 hydrogenase 2 accessory protein HypG 1534088 hybG 4850033 hybG Actinobacillus pleuropneumoniae serovar 5b str. L20 hydrogenase 2 accessory protein HypG YP_001054026.1 1533810 D 416269 CDS YP_001054027.1 126208802 4849033 complement(1534183..1534524) 1 NC_009053.1 hydrogenase nickel incorporation protein HybF 1534524 hybF 4849033 hybF Actinobacillus pleuropneumoniae serovar 5b str. L20 hydrogenase nickel incorporation protein HybF YP_001054027.1 1534183 R 416269 CDS YP_001054028.1 126208803 4849083 complement(1535447..1538896) 1 NC_009053.1 transcription-repair coupling factor 1538896 mfd 4849083 mfd Actinobacillus pleuropneumoniae serovar 5b str. L20 transcription-repair coupling factor YP_001054028.1 1535447 R 416269 CDS YP_001054029.1 126208804 4850410 1538998..1541607 1 NC_009053.1 aminopeptidase N 1541607 pepN 4850410 pepN Actinobacillus pleuropneumoniae serovar 5b str. L20 aminopeptidase N YP_001054029.1 1538998 D 416269 CDS YP_001054030.1 126208805 4849871 complement(1541745..1542335) 1 NC_009053.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsX; glycerol-3-phosphate acyltransferase PlsY 1542335 4849871 APL_1341 Actinobacillus pleuropneumoniae serovar 5b str. L20 glycerol-3-phosphate acyltransferase PlsY YP_001054030.1 1541745 R 416269 CDS YP_001054031.1 126208806 4849872 1542407..1542760 1 NC_009053.1 dihydroneopterin aldolase 1542760 folB 4849872 folB Actinobacillus pleuropneumoniae serovar 5b str. L20 dihydroneopterin aldolase YP_001054031.1 1542407 D 416269 CDS YP_001054032.1 126208807 4848536 1542869..1543762 1 NC_009053.1 Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis; cytidine deaminase 1543762 cdd 4848536 cdd Actinobacillus pleuropneumoniae serovar 5b str. L20 cytidine deaminase YP_001054032.1 1542869 D 416269 CDS YP_001054033.1 126208808 4848568 complement(1543809..1544747) 1 NC_009053.1 putative ABC transporter, membrane protein; cell division protein FtsX 1544747 ftsX 4848568 ftsX Actinobacillus pleuropneumoniae serovar 5b str. L20 cell division protein FtsX YP_001054033.1 1543809 R 416269 CDS YP_001054034.1 126208809 4849886 complement(1544757..1545410) 1 NC_009053.1 cell division ATP-binding protein FtsE 1545410 fstE 4849886 fstE Actinobacillus pleuropneumoniae serovar 5b str. L20 cell division ATP-binding protein FtsE YP_001054034.1 1544757 R 416269 CDS YP_001054035.1 126208810 4849585 complement(1545501..1547234) 1 NC_009053.1 cell division protein FtsY 1547234 ftsY 4849585 ftsY Actinobacillus pleuropneumoniae serovar 5b str. L20 cell division protein FtsY YP_001054035.1 1545501 R 416269 CDS YP_001054036.1 126208811 4850022 1547312..1547905 1 NC_009053.1 methylase 1547905 4850022 APL_1347 Actinobacillus pleuropneumoniae serovar 5b str. L20 methylase YP_001054036.1 1547312 D 416269 CDS YP_001054037.1 126208812 4850449 1547971..1548282 1 NC_009053.1 highly acidic protein; the structure of the Haemophilus influenzae protein shows similarity to uracil DNA glycosylase inhibitor (Ugi); binds heat-unstable protein (HU-alpha) which is a histone-like protein; dsDNA-mimic protein 1548282 4850449 APL_1348 Actinobacillus pleuropneumoniae serovar 5b str. L20 dsDNA-mimic protein YP_001054037.1 1547971 D 416269 CDS YP_001054038.1 126208813 4849417 1548298..1548810 1 NC_009053.1 4-hydroxyphenylacetic acid hydroxylase 1548810 hpaC 4849417 hpaC Actinobacillus pleuropneumoniae serovar 5b str. L20 4-hydroxyphenylacetic acid hydroxylase YP_001054038.1 1548298 D 416269 CDS YP_001054039.1 126208814 4849418 1548925..1549797 1 NC_009053.1 with TehA confers resistance to tellurite; tellurite resistance protein TehB 1549797 tehB 4849418 tehB Actinobacillus pleuropneumoniae serovar 5b str. L20 tellurite resistance protein TehB YP_001054039.1 1548925 D 416269 CDS YP_001054040.1 126208815 4850417 complement(1549925..1550608) 1 NC_009053.1 with ArtPQJI acts to transport arginine across the inner membrane; arginine transporter permease subunit ArtM 1550608 artM 4850417 artM Actinobacillus pleuropneumoniae serovar 5b str. L20 arginine transporter permease subunit ArtM YP_001054040.1 1549925 R 416269 CDS YP_001054041.1 126208816 4849758 complement(1550608..1551279) 1 NC_009053.1 with ArtPMJI transports arginine across the inner membrane; arginine transporter permease subunit ArtQ 1551279 artQ 4849758 artQ Actinobacillus pleuropneumoniae serovar 5b str. L20 arginine transporter permease subunit ArtQ YP_001054041.1 1550608 R 416269 CDS YP_001054042.1 126208817 4849504 complement(1551285..1552004) 1 NC_009053.1 arginine-binding periplasmic protein 1552004 artI 4849504 artI Actinobacillus pleuropneumoniae serovar 5b str. L20 arginine-binding periplasmic protein YP_001054042.1 1551285 R 416269 CDS YP_001054043.1 126208818 4850162 complement(1552024..1552758) 1 NC_009053.1 With ArtMQJI transports arginine across the inner membrane; arginine transporter ATP-binding subunit 1552758 artP 4850162 artP Actinobacillus pleuropneumoniae serovar 5b str. L20 arginine transporter ATP-binding subunit YP_001054043.1 1552024 R 416269 CDS YP_001054044.1 126208819 4850015 complement(1552983..1553480) 1 NC_009053.1 hypothetical protein 1553480 4850015 APL_1355 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054044.1 1552983 R 416269 CDS YP_001054045.1 126208820 4850416 1553553..1554515 1 NC_009053.1 sodium/calcium exchange protein 1554515 4850416 APL_1356 Actinobacillus pleuropneumoniae serovar 5b str. L20 sodium/calcium exchange protein YP_001054045.1 1553553 D 416269 CDS YP_001054046.1 126208821 4850500 complement(1554593..1554886) 1 NC_009053.1 HTH-type transcriptional regulator 1554886 4850500 APL_1357 Actinobacillus pleuropneumoniae serovar 5b str. L20 HTH-type transcriptional regulator YP_001054046.1 1554593 R 416269 CDS YP_001054047.1 126208822 4850501 complement(1554867..1555238) 1 NC_009053.1 hypothetical protein 1555238 4850501 APL_1358 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054047.1 1554867 R 416269 CDS YP_001054048.1 126208823 4849875 1555432..1557183 1 NC_009053.1 two electrons are transferred from cytoplasmic NADPH to thioredoxin and then to the inner membrane protein DsbD which keeps the disulfide isomerase DsbC in a reduced state in the oxidizing periplasm; DsbC in turns rearranges incorrectly made disulfide bonds in the periplasm; thiol:disulfide interchange protein 1557183 dipZ 4849875 dipZ Actinobacillus pleuropneumoniae serovar 5b str. L20 thiol:disulfide interchange protein YP_001054048.1 1555432 D 416269 CDS YP_001054049.1 126208824 4850555 1557241..1557810 1 NC_009053.1 hypothetical protein 1557810 4850555 APL_1360 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054049.1 1557241 D 416269 CDS YP_001054050.1 126208825 4848811 complement(1557854..1558708) 1 NC_009053.1 hypothetical protein 1558708 4848811 APL_1361 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054050.1 1557854 R 416269 CDS YP_001054051.1 126208826 4848800 1558781..1560529 1 NC_009053.1 hypothetical protein 1560529 4848800 APL_1362 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054051.1 1558781 D 416269 CDS YP_001054052.1 126208827 4850163 1560504..1560875 1 NC_009053.1 hypothetical protein 1560875 4850163 APL_1363 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054052.1 1560504 D 416269 CDS YP_001054053.1 126208828 4850556 1560884..1561462 1 NC_009053.1 phosphoheptose isomerase 1561462 gmhA 4850556 gmhA Actinobacillus pleuropneumoniae serovar 5b str. L20 phosphoheptose isomerase YP_001054053.1 1560884 D 416269 CDS YP_001054054.1 126208829 4849618 1561484..1562071 1 NC_009053.1 pubmed:8461417; hypothetical protein 1562071 hly 4849618 hly Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054054.1 1561484 D 416269 CDS YP_001054055.1 126208830 4849619 complement(1562283..1563650) 1 NC_009053.1 YfhD; uncharacterized member of the transglycosylase slt family; part of the rob operon, which plays a role in cellular resistance to antibiotics, bactericidal agents, and organic solvents; unknown function; transglycosylase 1563650 4849619 APL_1366 Actinobacillus pleuropneumoniae serovar 5b str. L20 transglycosylase YP_001054055.1 1562283 R 416269 CDS YP_001054056.1 126208831 4849019 complement(1564521..1566470) 1 NC_009053.1 cytochrome c-type biogenesis protein CcmF 1566470 ccmF 4849019 ccmF Actinobacillus pleuropneumoniae serovar 5b str. L20 cytochrome c-type biogenesis protein CcmF YP_001054056.1 1564521 R 416269 CDS YP_001054057.1 126208832 4850381 complement(1566470..1567015) 1 NC_009053.1 CycJ; periplasmic heme chaperone that binds heme transiently via a histidine residue and delivers it to newly synthesized and exported c-type cytochromes; requires the ATP hydrolysis activity of the CcmA protein in order to transfer the heme to the apocytochrome; part of the cytochrome c maturation system; periplasmic protein anchored to the inner membrane; cytochrome c-type biogenesis protein CcmE 1567015 ccmE 4850381 ccmE Actinobacillus pleuropneumoniae serovar 5b str. L20 cytochrome c-type biogenesis protein CcmE YP_001054057.1 1566470 R 416269 CDS YP_001054058.1 126208833 4850524 complement(1567199..1567396) 1 NC_009053.1 heme exporter protein D 1567396 ccmD 4850524 ccmD Actinobacillus pleuropneumoniae serovar 5b str. L20 heme exporter protein D YP_001054058.1 1567199 R 416269 CDS YP_001054059.1 126208834 4848862 complement(1567409..1568140) 1 NC_009053.1 heme exporter protein C 1568140 ccmC 4848862 ccmC Actinobacillus pleuropneumoniae serovar 5b str. L20 heme exporter protein C YP_001054059.1 1567409 R 416269 CDS YP_001054060.1 126208835 4849990 complement(1568191..1568853) 1 NC_009053.1 heme exporter protein B 1568853 ccmB 4849990 ccmB Actinobacillus pleuropneumoniae serovar 5b str. L20 heme exporter protein B YP_001054060.1 1568191 R 416269 CDS YP_001054061.1 126208836 4850250 complement(1568850..1569485) 1 NC_009053.1 ATP-binding protein; required for proper cytochrome c maturation; cytochrome c biogenesis protein CcmA 1569485 ccmA 4850250 ccmA Actinobacillus pleuropneumoniae serovar 5b str. L20 cytochrome c biogenesis protein CcmA YP_001054061.1 1568850 R 416269 CDS YP_001054062.1 126208837 4849253 complement(1569626..1570336) 1 NC_009053.1 controls initiation of DNA replication by inhibiting re-initiation of replication, promotes hydrolysis of DnaA-bound ATP; DNA replication initiation factor 1570336 4849253 APL_1373 Actinobacillus pleuropneumoniae serovar 5b str. L20 DNA replication initiation factor YP_001054062.1 1569626 R 416269 CDS YP_001054063.1 126208838 4850498 1576322..1577155 1 NC_009053.1 hypothetical protein 1577155 4850498 APL_1374 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054063.1 1576322 D 416269 CDS YP_001054064.1 126208839 4849424 1577337..1577594 1 NC_009053.1 catalyzes the decarboxylation of oxaloacetate to form pyruvate and carbon dioxide; oxaloacetate decarboxylase subunit gamma 1577594 oadG 4849424 oadG Actinobacillus pleuropneumoniae serovar 5b str. L20 oxaloacetate decarboxylase subunit gamma YP_001054064.1 1577337 D 416269 CDS YP_001054065.1 126208840 4850189 1577610..1579418 1 NC_009053.1 catalyzes the formation of pyruvate from oxaloacetate; oxaloacetate decarboxylase 1579418 oadA 4850189 oadA Actinobacillus pleuropneumoniae serovar 5b str. L20 oxaloacetate decarboxylase YP_001054065.1 1577610 D 416269 CDS YP_001054066.1 126208841 4850139 1579435..1580739 1 NC_009053.1 oxaloacetate decarboxylase subunit beta 1580739 oadB 4850139 oadB Actinobacillus pleuropneumoniae serovar 5b str. L20 oxaloacetate decarboxylase subunit beta YP_001054066.1 1579435 D 416269 CDS YP_001054067.1 126208842 4849084 1580872..1581195 1 NC_009053.1 alkylphosphonate uptake protein 1581195 phnA 4849084 phnA Actinobacillus pleuropneumoniae serovar 5b str. L20 alkylphosphonate uptake protein YP_001054067.1 1580872 D 416269 CDS YP_001054068.1 126208843 4849036 1581367..1582767 1 NC_009053.1 cytochrome c peroxidase 1582767 ccp 4849036 ccp Actinobacillus pleuropneumoniae serovar 5b str. L20 cytochrome c peroxidase YP_001054068.1 1581367 D 416269 CDS YP_001054069.1 126208844 4849305 complement(1582833..1583126) 1 NC_009053.1 hypothetical protein 1583126 4849305 APL_1380 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054069.1 1582833 R 416269 CDS YP_001054070.1 126208845 4850261 complement(1583128..1583661) 1 NC_009053.1 hypothetical protein 1583661 4850261 APL_1381 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054070.1 1583128 R 416269 CDS YP_001054071.1 126208846 4850186 complement(1583783..1584124) 1 NC_009053.1 hypothetical protein 1584124 4850186 APL_1382 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054071.1 1583783 R 416269 CDS YP_001054072.1 126208847 4850187 complement(1584180..1584932) 1 NC_009053.1 tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine; tRNA (guanine-N(7)-)-methyltransferase 1584932 trmB 4850187 trmB Actinobacillus pleuropneumoniae serovar 5b str. L20 tRNA (guanine-N(7)-)-methyltransferase YP_001054072.1 1584180 R 416269 CDS YP_001054073.1 126208848 4848572 complement(1584980..1585930) 1 NC_009053.1 FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs; 3-oxoacyl-ACP synthase 1585930 fabH 4848572 fabH Actinobacillus pleuropneumoniae serovar 5b str. L20 3-oxoacyl-ACP synthase YP_001054073.1 1584980 R 416269 CDS YP_001054074.1 126208849 4849428 complement(1585942..1586976) 1 NC_009053.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY; glycerol-3-phosphate acyltransferase PlsX 1586976 plsX 4849428 plsX Actinobacillus pleuropneumoniae serovar 5b str. L20 glycerol-3-phosphate acyltransferase PlsX YP_001054074.1 1585942 R 416269 CDS YP_001054075.1 126208850 4850127 complement(1587001..1587171) 1 NC_009053.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not; 50S ribosomal protein L32 1587171 rpmF 4850127 rpmF Actinobacillus pleuropneumoniae serovar 5b str. L20 50S ribosomal protein L32 YP_001054075.1 1587001 R 416269 CDS YP_001054076.1 126208851 4850529 complement(1587189..1587716) 1 NC_009053.1 hypothetical protein 1587716 4850529 APL_1387 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054076.1 1587189 R 416269 CDS YP_001054077.1 126208852 4849660 1587936..1588727 1 NC_009053.1 ABC transporter permease 1588727 4849660 APL_1388 Actinobacillus pleuropneumoniae serovar 5b str. L20 ABC transporter permease YP_001054077.1 1587936 D 416269 CDS YP_001054078.1 126208853 4849835 1588913..1590085 1 NC_009053.1 hypothetical protein 1590085 4849835 APL_1389 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054078.1 1588913 D 416269 CDS YP_001054079.1 126208854 4850434 1590464..1591978 1 NC_009053.1 sodium-dependent transporter 1591978 4850434 APL_1390 Actinobacillus pleuropneumoniae serovar 5b str. L20 sodium-dependent transporter YP_001054079.1 1590464 D 416269 CDS YP_001054080.1 126208855 4850435 1592366..1593337 1 NC_009053.1 Includes: Mannose-specific phosphotransferase enzyme IIA component; Mannose-specific phosphotransferase enzyme IIB component; PTS system mannose-specific transporter subunit IIAB 1593337 4850435 APL_1391 Actinobacillus pleuropneumoniae serovar 5b str. L20 PTS system mannose-specific transporter subunit IIAB YP_001054080.1 1592366 D 416269 CDS YP_001054081.1 126208856 4850313 1593350..1594150 1 NC_009053.1 mannose permease IIC component 1594150 ptnC 4850313 ptnC Actinobacillus pleuropneumoniae serovar 5b str. L20 mannose permease IIC component YP_001054081.1 1593350 D 416269 CDS YP_001054082.1 126208857 4849514 1594164..1595000 1 NC_009053.1 hosphoenolpyruvate-dependent sugar phosphotransferase system catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IID with IIC forms the translocation channel; PTS system mannose-specific transporter subunit IID 1595000 ptnD 4849514 ptnD Actinobacillus pleuropneumoniae serovar 5b str. L20 PTS system mannose-specific transporter subunit IID YP_001054082.1 1594164 D 416269 CDS YP_001054083.1 126208858 4850317 1595099..1595557 1 NC_009053.1 hypothetical protein 1595557 4850317 APL_1394 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054083.1 1595099 D 416269 CDS YP_001054084.1 126208859 4850440 1595554..1596759 1 NC_009053.1 mannose-6-phosphate isomerase 1596759 manA 4850440 manA Actinobacillus pleuropneumoniae serovar 5b str. L20 mannose-6-phosphate isomerase YP_001054084.1 1595554 D 416269 CDS YP_001054085.1 126208860 4849392 1596821..1597336 1 NC_009053.1 hypothetical protein 1597336 4849392 APL_1396 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054085.1 1596821 D 416269 CDS YP_001054086.1 126208861 4850068 complement(1597474..1598262) 1 NC_009053.1 hypothetical protein 1598262 4850068 APL_1397 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054086.1 1597474 R 416269 CDS YP_001054087.1 126208862 4850108 complement(1598554..1599738) 1 NC_009053.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu 1599738 tufB 4850108 tufB Actinobacillus pleuropneumoniae serovar 5b str. L20 elongation factor Tu YP_001054087.1 1598554 R 416269 CDS YP_001054088.1 126208863 4850109 complement(1599800..1601905) 1 NC_009053.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G 1601905 fusA 4850109 fusA Actinobacillus pleuropneumoniae serovar 5b str. L20 elongation factor G YP_001054088.1 1599800 R 416269 CDS YP_001054089.1 126208864 4849915 complement(1602005..1602475) 1 NC_009053.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit; 30S ribosomal protein S7 1602475 rpsG 4849915 rpsG Actinobacillus pleuropneumoniae serovar 5b str. L20 30S ribosomal protein S7 YP_001054089.1 1602005 R 416269 CDS YP_001054090.1 126208865 4849900 complement(1602612..1602986) 1 NC_009053.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance; 30S ribosomal protein S12 1602986 rpsL 4849900 rpsL Actinobacillus pleuropneumoniae serovar 5b str. L20 30S ribosomal protein S12 YP_001054090.1 1602612 R 416269 CDS YP_001054091.1 126208866 4850499 complement(1603108..1604067) 1 NC_009053.1 ADP-heptose--LPS heptosyltransferase 1604067 rfaC 4850499 rfaC Actinobacillus pleuropneumoniae serovar 5b str. L20 ADP-heptose--LPS heptosyltransferase YP_001054091.1 1603108 R 416269 CDS YP_001054092.1 126208867 4850170 complement(1604143..1605180) 1 NC_009053.1 ADP-heptose--LPS heptosyltransferase 1605180 rfaF 4850170 rfaF Actinobacillus pleuropneumoniae serovar 5b str. L20 ADP-heptose--LPS heptosyltransferase YP_001054092.1 1604143 R 416269 CDS YP_001054093.1 126208868 4850393 complement(1605262..1605666) 1 NC_009053.1 opacity associated protein B 1605666 oapB 4850393 oapB Actinobacillus pleuropneumoniae serovar 5b str. L20 opacity associated protein B YP_001054093.1 1605262 R 416269 CDS YP_001054094.1 126208869 4848876 complement(1605788..1607179) 1 NC_009053.1 opacity associated protein A 1607179 oapA 4848876 oapA Actinobacillus pleuropneumoniae serovar 5b str. L20 opacity associated protein A YP_001054094.1 1605788 R 416269 CDS YP_001054095.1 126208870 4849558 1607480..1607824 1 NC_009053.1 DNA uptake protein 1607824 comEA 4849558 comEA Actinobacillus pleuropneumoniae serovar 5b str. L20 DNA uptake protein YP_001054095.1 1607480 D 416269 CDS YP_001054096.1 126208871 4849559 1607975..1608868 1 NC_009053.1 catalyzes the decarboxylation of phosphatidyl-L-serine to phosphatidylethanoleamine; phosphatidylserine decarboxylase 1608868 psd 4849559 psd Actinobacillus pleuropneumoniae serovar 5b str. L20 phosphatidylserine decarboxylase YP_001054096.1 1607975 D 416269 CDS YP_001054097.1 126208872 4848463 1609024..1611297 1 NC_009053.1 Synthesizes glutathione from L-glutamate and L-cysteine via gamma-L-glutamyl-L-cysteine; bifunctional glutamate--cysteine ligase/glutathione synthetase 1611297 gshA 4848463 gshA Actinobacillus pleuropneumoniae serovar 5b str. L20 bifunctional glutamate--cysteine ligase/glutathione synthetase YP_001054097.1 1609024 D 416269 CDS YP_001054098.1 126208873 4850048 complement(1611389..1612009) 1 NC_009053.1 CueR-like transcriptional regulator 1612009 4850048 APL_1409 Actinobacillus pleuropneumoniae serovar 5b str. L20 CueR-like transcriptional regulator YP_001054098.1 1611389 R 416269 CDS YP_001054099.1 126208874 4850161 1612209..1613411 1 NC_009053.1 ttryptophan-specific transport protein 1613411 tnaB 4850161 tnaB Actinobacillus pleuropneumoniae serovar 5b str. L20 ttryptophan-specific transport protein YP_001054099.1 1612209 D 416269 CDS YP_001054100.1 126208875 4849501 complement(1613475..1613768) 1 NC_009053.1 hypothetical protein 1613768 4849501 APL_1411 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054100.1 1613475 R 416269 CDS YP_001054101.1 126208876 4849606 1613908..1614810 1 NC_009053.1 oxidoreductase 1614810 4849606 APL_1412 Actinobacillus pleuropneumoniae serovar 5b str. L20 oxidoreductase YP_001054101.1 1613908 D 416269 CDS YP_001054102.1 126208877 4848649 complement(1614873..1616648) 1 NC_009053.1 long-chain-fatty-acid--CoA ligase 1616648 4848649 APL_1413 Actinobacillus pleuropneumoniae serovar 5b str. L20 long-chain-fatty-acid--CoA ligase YP_001054102.1 1614873 R 416269 CDS YP_001054103.1 126208878 4850549 complement(1616829..1618304) 1 NC_009053.1 malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate; malate:quinone oxidoreductase 1618304 mqo 4850549 mqo Actinobacillus pleuropneumoniae serovar 5b str. L20 malate:quinone oxidoreductase YP_001054103.1 1616829 R 416269 CDS YP_001054104.1 126208879 4850550 complement(1618412..1618825) 1 NC_009053.1 hypothetical protein 1618825 4850550 APL_1415 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054104.1 1618412 R 416269 CDS YP_001054105.1 126208880 4848548 1619045..1619386 1 NC_009053.1 hypothetical protein 1619386 4848548 APL_1416 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054105.1 1619045 D 416269 CDS YP_001054106.1 126208881 4848870 1619428..1619853 1 NC_009053.1 hypothetical protein 1619853 4848870 APL_1417 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054106.1 1619428 D 416269 CDS YP_001054107.1 126208882 4849553 complement(1619924..1620934) 1 NC_009053.1 ABC transporter; functions in galactose transport; part of MglA2C2B transporter complex; beta-methylgalactoside transporter inner membrane protein 1620934 mglC 4849553 mglC Actinobacillus pleuropneumoniae serovar 5b str. L20 beta-methylgalactoside transporter inner membrane protein YP_001054107.1 1619924 R 416269 CDS YP_001054108.1 126208883 4849247 complement(1620951..1622450) 1 NC_009053.1 with MglBC transports galactose or methyl galactoside into the cell; contains 2 ATP binding domains; galactose/methyl galaxtoside transporter ATP-binding protein 1622450 mglA 4849247 mglA Actinobacillus pleuropneumoniae serovar 5b str. L20 galactose/methyl galaxtoside transporter ATP-binding protein YP_001054108.1 1620951 R 416269 CDS YP_001054109.1 126208884 4850497 complement(1622513..1623505) 1 NC_009053.1 D-galactose-binding periplasmic protein 1623505 mglB 4850497 mglB Actinobacillus pleuropneumoniae serovar 5b str. L20 D-galactose-binding periplasmic protein YP_001054109.1 1622513 R 416269 CDS YP_001054110.1 126208885 4850046 complement(1623759..1624865) 1 NC_009053.1 outer membrane protein P5 1624865 ompA 4850046 ompA Actinobacillus pleuropneumoniae serovar 5b str. L20 outer membrane protein P5 YP_001054110.1 1623759 R 416269 CDS YP_001054111.1 126208886 4848874 1625293..1628382 1 NC_009053.1 hypothetical protein 1628382 4848874 APL_1422 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054111.1 1625293 D 416269 CDS YP_001054112.1 126208887 4848875 1628515..1628940 1 NC_009053.1 hypothetical protein 1628940 4848875 APL_1423 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054112.1 1628515 D 416269 CDS YP_001054113.1 126208888 4849881 1629241..1630722 1 NC_009053.1 functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria; inner membrane protein translocase component YidC 1630722 oxaA 4849881 oxaA Actinobacillus pleuropneumoniae serovar 5b str. L20 inner membrane protein translocase component YidC YP_001054113.1 1629241 D 416269 CDS YP_001054114.1 126208889 4848707 complement(1631007..1631621) 1 NC_009053.1 cytochrome c-type protein NapC 1631621 napC 4848707 napC Actinobacillus pleuropneumoniae serovar 5b str. L20 cytochrome c-type protein NapC YP_001054114.1 1631007 R 416269 CDS YP_001054115.1 126208890 4848740 complement(1631633..1632055) 1 NC_009053.1 nitrate reductase cytochrome c-type subunit 1632055 napB 4848740 napB Actinobacillus pleuropneumoniae serovar 5b str. L20 nitrate reductase cytochrome c-type subunit YP_001054115.1 1631633 R 416269 CDS YP_001054116.1 126208891 4849477 complement(1632074..1632967) 1 NC_009053.1 part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA; quinol dehydrogenase membrane component 1632967 napH 4849477 napH Actinobacillus pleuropneumoniae serovar 5b str. L20 quinol dehydrogenase membrane component YP_001054116.1 1632074 R 416269 CDS YP_001054117.1 126208892 4850453 complement(1632967..1633872) 1 NC_009053.1 part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA; secreted by twin arginine translocation pathway; quinol dehydrogenase periplasmic component 1633872 napG 4850453 napG Actinobacillus pleuropneumoniae serovar 5b str. L20 quinol dehydrogenase periplasmic component YP_001054117.1 1632967 R 416269 CDS YP_001054118.1 126208893 4850345 complement(1634007..1636490) 1 NC_009053.1 periplasmic; catalytic subunit; with NapBC catalyzes the reduction of nitrate to nitrite; NapAB receives electrons from NapC; nitrate reductase catalytic subunit 1636490 napA 4850345 napA Actinobacillus pleuropneumoniae serovar 5b str. L20 nitrate reductase catalytic subunit YP_001054118.1 1634007 R 416269 CDS YP_001054119.1 126208894 4848830 complement(1636522..1636791) 1 NC_009053.1 napD protein 1636791 napD 4848830 napD Actinobacillus pleuropneumoniae serovar 5b str. L20 napD protein YP_001054119.1 1636522 R 416269 CDS YP_001054120.1 126208895 4848831 complement(1636794..1637324) 1 NC_009053.1 ferredoxin-type protein NapF 1637324 napF 4848831 napF Actinobacillus pleuropneumoniae serovar 5b str. L20 ferredoxin-type protein NapF YP_001054120.1 1636794 R 416269 CDS YP_001054121.1 126208896 4849188 1637523..1638098 1 NC_009053.1 NAD(P)H oxidoreductase 1638098 4849188 APL_1432 Actinobacillus pleuropneumoniae serovar 5b str. L20 NAD(P)H oxidoreductase YP_001054121.1 1637523 D 416269 CDS YP_001054122.1 126208897 4850105 complement(1638234..1639016) 1 NC_009053.1 transposase 1639016 4850105 APL_1433 Actinobacillus pleuropneumoniae serovar 5b str. L20 transposase YP_001054122.1 1638234 R 416269 CDS YP_001054123.1 126208898 4849233 complement(1639058..1639567) 1 NC_009053.1 hypothetical protein 1639567 4849233 APL_1434 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054123.1 1639058 R 416269 CDS YP_001054124.1 126208899 4848901 complement(1639673..1640185) 1 NC_009053.1 hypothetical protein 1640185 4848901 APL_1435 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054124.1 1639673 R 416269 CDS YP_001054125.1 126208900 4848780 complement(1640346..1643333) 1 NC_009053.1 ribonuclease E 1643333 rne 4848780 rne Actinobacillus pleuropneumoniae serovar 5b str. L20 ribonuclease E YP_001054125.1 1640346 R 416269 CDS YP_001054126.1 126208901 4849229 1643803..1644810 1 NC_009053.1 hypothetical protein 1644810 4849229 APL_1437 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054126.1 1643803 D 416269 CDS YP_001054127.1 126208902 4850542 complement(1644880..1645401) 1 NC_009053.1 hypothetical protein 1645401 4850542 APL_1438 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054127.1 1644880 R 416269 CDS YP_001054128.1 126208903 4850543 complement(1645551..1647014) 1 NC_009053.1 3-octaprenyl-4-hydroxybenzoate carboxy-lyase 1647014 ubiD 4850543 ubiD Actinobacillus pleuropneumoniae serovar 5b str. L20 3-octaprenyl-4-hydroxybenzoate carboxy-lyase YP_001054128.1 1645551 R 416269 CDS YP_001054129.1 126208904 4850149 1647160..1648137 1 NC_009053.1 involved in transport of zinc(II) with ZnuA and C; high-affinity zinc transporter periplasmic protein 1648137 znuA 4850149 znuA Actinobacillus pleuropneumoniae serovar 5b str. L20 high-affinity zinc transporter periplasmic protein YP_001054129.1 1647160 D 416269 CDS YP_001054130.1 126208905 4849338 complement(1648236..1648847) 1 NC_009053.1 hypothetical protein 1648847 4849338 APL_1441 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054130.1 1648236 R 416269 CDS YP_001054131.1 126208906 4849611 complement(1649278..1650714) 1 NC_009053.1 RTX-I toxin secretion component 1650714 apxID 4849611 apxID Actinobacillus pleuropneumoniae serovar 5b str. L20 RTX-I toxin secretion component YP_001054131.1 1649278 R 416269 CDS YP_001054132.1 126208907 4850021 complement(1650723..1652846) 1 NC_009053.1 pubmed:8181764; toxin RTX-I translocation ATP-binding protein 1652846 apxIB 4850021 apxIB Actinobacillus pleuropneumoniae serovar 5b str. L20 toxin RTX-I translocation ATP-binding protein YP_001054132.1 1650723 R 416269 CDS YP_001054133.1 126208908 4850247 complement(1652927..1655995) 1 NC_009053.1 pubmed:8359891; RTX-I toxin determinant A 1655995 apxIA 4850247 apxIA Actinobacillus pleuropneumoniae serovar 5b str. L20 RTX-I toxin determinant A YP_001054133.1 1652927 R 416269 CDS YP_001054134.1 126208909 4849898 complement(1656005..1656523) 1 NC_009053.1 pubmed:8359891; RTX-I toxin-activating lysine-acyltransferase ApxIC 1656523 apxIC 4849898 apxIC Actinobacillus pleuropneumoniae serovar 5b str. L20 RTX-I toxin-activating lysine-acyltransferase ApxIC YP_001054134.1 1656005 R 416269 CDS YP_001054135.1 126208910 4850146 1656814..1657854 1 NC_009053.1 Fe3+ ABC transporter periplasmic protein 1657854 afuA 4850146 afuA Actinobacillus pleuropneumoniae serovar 5b str. L20 Fe3+ ABC transporter periplasmic protein YP_001054135.1 1656814 D 416269 CDS YP_001054136.1 126208911 4850147 1657959..1660022 1 NC_009053.1 ferric transport system permease fbpB 1660022 afuB 4850147 afuB Actinobacillus pleuropneumoniae serovar 5b str. L20 ferric transport system permease fbpB YP_001054136.1 1657959 D 416269 CDS YP_001054137.1 126208912 4850154 1660069..1661115 1 NC_009053.1 Part of the ABC transporter complex FbpABC involved in Fe(3+) ions import; ferric transporter ATP-binding subunit 1661115 fbpC 4850154 fbpC Actinobacillus pleuropneumoniae serovar 5b str. L20 ferric transporter ATP-binding subunit YP_001054137.1 1660069 D 416269 CDS YP_001054138.1 126208913 4849899 complement(1661206..1662570) 1 NC_009053.1 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase 1662570 mpl 4849899 mpl Actinobacillus pleuropneumoniae serovar 5b str. L20 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase YP_001054138.1 1661206 R 416269 CDS YP_001054139.1 126208914 4849228 1662693..1663697 1 NC_009053.1 catalyzes the formation of D-fructose 6-phosphate from fructose-1,6-bisphosphate; fructose-1,6-bisphosphatase 1663697 fbp 4849228 fbp Actinobacillus pleuropneumoniae serovar 5b str. L20 fructose-1,6-bisphosphatase YP_001054139.1 1662693 D 416269 CDS YP_001054140.1 126208915 4849230 complement(1663853..1664464) 1 NC_009053.1 hypothetical protein 1664464 4849230 APL_1451 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054140.1 1663853 R 416269 CDS YP_001054141.1 126208916 4849901 complement(1664928..1666157) 1 NC_009053.1 catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate; D-3-phosphoglycerate dehydrogenase 1666157 serA 4849901 serA Actinobacillus pleuropneumoniae serovar 5b str. L20 D-3-phosphoglycerate dehydrogenase YP_001054141.1 1664928 R 416269 CDS YP_001054142.1 126208917 4850152 complement(1666301..1666960) 1 NC_009053.1 Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway; ribose-5-phosphate isomerase A 1666960 rpiA 4850152 rpiA Actinobacillus pleuropneumoniae serovar 5b str. L20 ribose-5-phosphate isomerase A YP_001054142.1 1666301 R 416269 CDS YP_001054143.1 126208918 4849540 complement(1667107..1668441) 1 NC_009053.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; phosphoglucosamine mutase 1668441 glmM 4849540 glmM Actinobacillus pleuropneumoniae serovar 5b str. L20 phosphoglucosamine mutase YP_001054143.1 1667107 R 416269 CDS YP_001054144.1 126208919 4849541 complement(1668513..1670039) 1 NC_009053.1 threonine deaminase; threonine dehydratase; in Escherichia coli, IlvA is part of the isoleucine biosynthetic pathway; threonine dehydratase 1670039 ilvA 4849541 ilvA Actinobacillus pleuropneumoniae serovar 5b str. L20 threonine dehydratase YP_001054144.1 1668513 R 416269 CDS YP_001054145.1 126208920 4849499 complement(1670166..1670762) 1 NC_009053.1 FKBP-type peptidyl-prolyl cis-trans isomerase SlyD 1670762 slyD 4849499 slyD Actinobacillus pleuropneumoniae serovar 5b str. L20 FKBP-type peptidyl-prolyl cis-trans isomerase SlyD YP_001054145.1 1670166 R 416269 CDS YP_001054146.1 126208921 4849383 complement(1671115..1671801) 1 NC_009053.1 aquaporin Z 1671801 aqpZ 4849383 aqpZ Actinobacillus pleuropneumoniae serovar 5b str. L20 aquaporin Z YP_001054146.1 1671115 R 416269 CDS YP_001054147.1 126208922 4850293 complement(1671947..1672663) 1 NC_009053.1 hypothetical protein 1672663 4850293 APL_1458 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054147.1 1671947 R 416269 CDS YP_001054148.1 126208923 4850249 complement(1672705..1673460) 1 NC_009053.1 hypothetical protein 1673460 4850249 APL_1459 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054148.1 1672705 R 416269 CDS YP_001054149.1 126208924 4849443 1673509..1674525 1 NC_009053.1 hypothetical protein 1674525 4849443 APL_1460 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054149.1 1673509 D 416269 CDS YP_001054150.1 126208925 4848805 1674525..1675433 1 NC_009053.1 catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate; 1,4-dihydroxy-2-naphthoate octaprenyltransferase 1675433 menA 4848805 menA Actinobacillus pleuropneumoniae serovar 5b str. L20 1,4-dihydroxy-2-naphthoate octaprenyltransferase YP_001054150.1 1674525 D 416269 CDS YP_001054151.1 126208926 4849052 complement(1675512..1675853) 1 NC_009053.1 essential respiratory protein A; may be involved in the transfer of iron-sulfur clusters; essential for growth using oxygen or alternate electron acceptors; iron-sulfur cluster insertion protein ErpA 1675853 4849052 APL_1462 Actinobacillus pleuropneumoniae serovar 5b str. L20 iron-sulfur cluster insertion protein ErpA YP_001054151.1 1675512 R 416269 CDS YP_001054152.1 126208927 4849053 1676054..1676845 1 NC_009053.1 ABC-transporter 1676845 4849053 APL_1463 Actinobacillus pleuropneumoniae serovar 5b str. L20 ABC-transporter YP_001054152.1 1676054 D 416269 CDS YP_001054153.1 126208928 4849745 1676845..1677576 1 NC_009053.1 ABC transporter 1677576 wzm 4849745 wzm Actinobacillus pleuropneumoniae serovar 5b str. L20 ABC transporter YP_001054153.1 1676845 D 416269 CDS YP_001054154.1 126208929 4848719 1677587..1678366 1 NC_009053.1 hypothetical protein 1678366 4848719 APL_1465 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054154.1 1677587 D 416269 CDS YP_001054155.1 126208930 4849191 1679260..1679664 1 NC_009053.1 hypothetical protein 1679664 4849191 APL_1466 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054155.1 1679260 D 416269 CDS YP_001054156.1 126208931 4849905 1679666..1680814 1 NC_009053.1 UDP-galactopyranose mutase 1680814 rfbD 4849905 rfbD Actinobacillus pleuropneumoniae serovar 5b str. L20 UDP-galactopyranose mutase YP_001054156.1 1679666 D 416269 CDS YP_001054157.1 126208932 4849363 1680877..1681446 1 NC_009053.1 hypothetical protein 1681446 4849363 APL_1468 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054157.1 1680877 D 416269 CDS YP_001054158.1 126208933 4848665 1681443..1682366 1 NC_009053.1 glycosyl transferase family protein 1682366 4848665 APL_1469 Actinobacillus pleuropneumoniae serovar 5b str. L20 glycosyl transferase family protein YP_001054158.1 1681443 D 416269 CDS YP_001054159.1 126208934 4849146 1682372..1683145 1 NC_009053.1 hypothetical protein 1683145 4849146 APL_1470 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054159.1 1682372 D 416269 CDS YP_001054160.1 126208935 4849147 1683164..1684582 1 NC_009053.1 sugar transferase 1684582 4849147 APL_1471 Actinobacillus pleuropneumoniae serovar 5b str. L20 sugar transferase YP_001054160.1 1683164 D 416269 CDS YP_001054161.1 126208936 4850143 1684665..1685738 1 NC_009053.1 dTDP-glucose 4,6-dehydratase 1685738 rfbB1 4850143 rfbB1 Actinobacillus pleuropneumoniae serovar 5b str. L20 dTDP-glucose 4,6-dehydratase YP_001054161.1 1684665 D 416269 CDS YP_001054162.1 126208937 4849891 1685959..1686174 1 NC_009053.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA; 30S ribosomal protein S21 1686174 rpsU 4849891 rpsU Actinobacillus pleuropneumoniae serovar 5b str. L20 30S ribosomal protein S21 YP_001054162.1 1685959 D 416269 CDS YP_001054163.1 126208938 4849503 1686354..1688096 1 NC_009053.1 synthesizes RNA primers at the replication forks; DNA primase 1688096 dnaG 4849503 dnaG Actinobacillus pleuropneumoniae serovar 5b str. L20 DNA primase YP_001054163.1 1686354 D 416269 CDS YP_001054164.1 126208939 4849057 1688201..1690060 1 NC_009053.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this is the primary sigma factor of bacteria; RNA polymerase sigma factor RpoD 1690060 rpoD 4849057 rpoD Actinobacillus pleuropneumoniae serovar 5b str. L20 RNA polymerase sigma factor RpoD YP_001054164.1 1688201 D 416269 CDS YP_001054165.1 126208940 4849892 complement(1690213..1691403) 1 NC_009053.1 catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr); tyrosyl-tRNA synthetase 1691403 tyrS 4849892 tyrS Actinobacillus pleuropneumoniae serovar 5b str. L20 tyrosyl-tRNA synthetase YP_001054165.1 1690213 R 416269 CDS YP_001054166.1 126208941 4848796 complement(1691748..1692212) 1 NC_009053.1 hypothetical protein 1692212 4848796 APL_1477 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054166.1 1691748 R 416269 CDS YP_001054167.1 126208942 4850023 complement(1692326..1694683) 1 NC_009053.1 ribonuclease R 1694683 vacB 4850023 vacB Actinobacillus pleuropneumoniae serovar 5b str. L20 ribonuclease R YP_001054167.1 1692326 R 416269 CDS YP_001054168.1 126208943 4850024 complement(1694751..1695266) 1 NC_009053.1 thioredoxin-like protein 1695266 4850024 APL_1479 Actinobacillus pleuropneumoniae serovar 5b str. L20 thioredoxin-like protein YP_001054168.1 1694751 R 416269 CDS YP_001054169.1 126208944 4849546 complement(1695266..1695898) 1 NC_009053.1 negatively controls the expression of fabA and fabB, genes involved in the unsaturated fatty acid biosynthesis; DNA-binding transcriptional repressor FabR 1695898 4849546 APL_1480 Actinobacillus pleuropneumoniae serovar 5b str. L20 DNA-binding transcriptional repressor FabR YP_001054169.1 1695266 R 416269 CDS YP_001054170.1 126208945 4850297 complement(1695891..1696784) 1 NC_009053.1 Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS, dps, fur and grxA; DNA-binding transcriptional regulator OxyR 1696784 oxyR 4850297 oxyR Actinobacillus pleuropneumoniae serovar 5b str. L20 DNA-binding transcriptional regulator OxyR YP_001054170.1 1695891 R 416269 CDS YP_001054171.1 126208946 4849888 1696909..1697643 1 NC_009053.1 hybrid peroxiredoxin HyPrx5 1697643 4849888 APL_1482 Actinobacillus pleuropneumoniae serovar 5b str. L20 hybrid peroxiredoxin HyPrx5 YP_001054171.1 1696909 D 416269 CDS YP_001054172.1 126208947 4849902 1698048..1698659 1 NC_009053.1 hypothetical protein 1698659 4849902 APL_1483 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054172.1 1698048 D 416269 CDS YP_001054173.1 126208948 4848806 complement(1698893..1699525) 1 NC_009053.1 hypothetical protein 1699525 4848806 APL_1484 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054173.1 1698893 R 416269 CDS YP_001054174.1 126208949 4848730 complement(1699929..1700789) 1 NC_009053.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal; pyridoxamine kinase 1700789 pdxY 4848730 pdxY Actinobacillus pleuropneumoniae serovar 5b str. L20 pyridoxamine kinase YP_001054174.1 1699929 R 416269 CDS YP_001054175.1 126208950 4849457 complement(1701093..1702046) 1 NC_009053.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein; acetyl-CoA carboxylase carboxyltransferase subunit alpha 1702046 accA 4849457 accA Actinobacillus pleuropneumoniae serovar 5b str. L20 acetyl-CoA carboxylase carboxyltransferase subunit alpha YP_001054175.1 1701093 R 416269 CDS YP_001054176.1 126208951 4850294 complement(1702163..1703572) 1 NC_009053.1 protein SufI 1703572 sufI 4850294 sufI Actinobacillus pleuropneumoniae serovar 5b str. L20 protein SufI YP_001054176.1 1702163 R 416269 CDS YP_001054177.1 126208952 4849225 complement(1703581..1704315) 1 NC_009053.1 1-acyl-sn-glycerol-3-phosphate acyltransferase 1704315 plsC 4849225 plsC Actinobacillus pleuropneumoniae serovar 5b str. L20 1-acyl-sn-glycerol-3-phosphate acyltransferase YP_001054177.1 1703581 R 416269 CDS YP_001054178.1 126208953 4850369 1704458..1704958 1 NC_009053.1 antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein; thiol peroxidase 1704958 tpx 4850369 tpx Actinobacillus pleuropneumoniae serovar 5b str. L20 thiol peroxidase YP_001054178.1 1704458 D 416269 CDS YP_001054179.1 126208954 4850018 1705081..1706439 1 NC_009053.1 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE; tRNA modification GTPase TrmE 1706439 trmE 4850018 trmE Actinobacillus pleuropneumoniae serovar 5b str. L20 tRNA modification GTPase TrmE YP_001054179.1 1705081 D 416269 CDS YP_001054180.1 126208955 4849648 complement(1706547..1707902) 1 NC_009053.1 hypothetical protein 1707902 4849648 APL_1491 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054180.1 1706547 R 416269 CDS YP_001054181.1 126208956 4849649 complement(1707915..1708187) 1 NC_009053.1 ACT domain-containing protein; hypothetical protein 1708187 4849649 APL_1492 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054181.1 1707915 R 416269 CDS YP_001054182.1 126208957 4848885 complement(1708325..1709014) 1 NC_009053.1 hypothetical protein 1709014 4848885 APL_1493 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054182.1 1708325 R 416269 CDS YP_001054183.1 126208958 4849748 1709330..1709899 1 NC_009053.1 fine tangled pili major subunit 1709899 ftpA 4849748 ftpA Actinobacillus pleuropneumoniae serovar 5b str. L20 fine tangled pili major subunit YP_001054183.1 1709330 D 416269 CDS YP_001054184.1 126208959 4849664 1710145..1710447 1 NC_009053.1 transcriptional regulator 1710447 4849664 APL_1495 Actinobacillus pleuropneumoniae serovar 5b str. L20 transcriptional regulator YP_001054184.1 1710145 D 416269 CDS YP_001054185.1 126208960 4849741 1710594..1711958 1 NC_009053.1 hypothetical protein 1711958 4849741 APL_1496 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054185.1 1710594 D 416269 CDS YP_001054186.1 126208961 4849544 complement(1712026..1714200) 1 NC_009053.1 hypothetical protein 1714200 4849544 APL_1497 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054186.1 1712026 R 416269 CDS YP_001054187.1 126208962 4849849 complement(1714282..1714740) 1 NC_009053.1 catalyzes the formation of methylglyoxal from glycerone phosphate; methylglyoxal synthase 1714740 mgsA 4849849 mgsA Actinobacillus pleuropneumoniae serovar 5b str. L20 methylglyoxal synthase YP_001054187.1 1714282 R 416269 CDS YP_001054188.1 126208963 4848887 1714873..1716153 1 NC_009053.1 catalyzes the formation of L-threonine from O-phospho-L-homoserine; threonine synthase 1716153 thrC 4848887 thrC Actinobacillus pleuropneumoniae serovar 5b str. L20 threonine synthase YP_001054188.1 1714873 D 416269 CDS YP_001054189.1 126208964 4848888 1716239..1716748 1 NC_009053.1 hypothetical protein 1716748 4848888 APL_1500 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054189.1 1716239 D 416269 CDS YP_001054190.1 126208965 4848778 1716790..1717572 1 NC_009053.1 transposase 1717572 4848778 APL_1501 Actinobacillus pleuropneumoniae serovar 5b str. L20 transposase YP_001054190.1 1716790 D 416269 CDS YP_001054191.1 126208966 4849983 complement(1717631..1720495) 1 NC_009053.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain; valyl-tRNA synthetase 1720495 valS 4849983 valS Actinobacillus pleuropneumoniae serovar 5b str. L20 valyl-tRNA synthetase YP_001054191.1 1717631 R 416269 CDS YP_001054192.1 126208967 4849224 complement(1721238..1721414) 1 NC_009053.1 hypothetical protein 1721414 4849224 APL_1503 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054192.1 1721238 R 416269 CDS YP_001054193.1 126208968 4850374 complement(1721574..1721996) 1 NC_009053.1 acetyltransferase 1721996 4850374 APL_1504 Actinobacillus pleuropneumoniae serovar 5b str. L20 acetyltransferase YP_001054193.1 1721574 R 416269 CDS YP_001054194.1 126208969 4849759 complement(1721997..1722434) 1 NC_009053.1 binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB; DNA polymerase III subunit chi 1722434 holC 4849759 holC Actinobacillus pleuropneumoniae serovar 5b str. L20 DNA polymerase III subunit chi YP_001054194.1 1721997 R 416269 CDS YP_001054195.1 126208970 4850148 1722708..1723151 1 NC_009053.1 LysM domain/BON superfamily protein 1723151 4850148 APL_1506 Actinobacillus pleuropneumoniae serovar 5b str. L20 LysM domain/BON superfamily protein YP_001054195.1 1722708 D 416269 CDS YP_001054196.1 126208971 4849723 1723353..1724654 1 NC_009053.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer; trigger factor 1724654 tig 4849723 tig Actinobacillus pleuropneumoniae serovar 5b str. L20 trigger factor YP_001054196.1 1723353 D 416269 CDS YP_001054197.1 126208972 4849724 1724787..1725236 1 NC_009053.1 rhodanese-related sulfurtransferase 1725236 4849724 APL_1508 Actinobacillus pleuropneumoniae serovar 5b str. L20 rhodanese-related sulfurtransferase YP_001054197.1 1724787 D 416269 CDS YP_001054198.1 126208973 4849426 1725261..1725761 1 NC_009053.1 molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA; preprotein translocase subunit SecB 1725761 secB 4849426 secB Actinobacillus pleuropneumoniae serovar 5b str. L20 preprotein translocase subunit SecB YP_001054198.1 1725261 D 416269 CDS YP_001054199.1 126208974 4850014 1725946..1726956 1 NC_009053.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase 1726956 gpsA 4850014 gpsA Actinobacillus pleuropneumoniae serovar 5b str. L20 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase YP_001054199.1 1725946 D 416269 CDS YP_001054200.1 126208975 4849361 1726968..1727783 1 NC_009053.1 catalyzes the O-acetylation of serine; serine acetyltransferase 1727783 cysE 4849361 cysE Actinobacillus pleuropneumoniae serovar 5b str. L20 serine acetyltransferase YP_001054200.1 1726968 D 416269 CDS YP_001054201.1 126208976 4849708 complement(1727979..1729163) 1 NC_009053.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu 1729163 tufB 4849708 tufB Actinobacillus pleuropneumoniae serovar 5b str. L20 elongation factor Tu YP_001054201.1 1727979 R 416269 CDS YP_001054202.1 126208977 4850403 1729917..1730867 1 NC_009053.1 catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis; pantothenate kinase 1730867 coaA 4850403 coaA Actinobacillus pleuropneumoniae serovar 5b str. L20 pantothenate kinase YP_001054202.1 1729917 D 416269 CDS YP_001054203.1 126208978 4848702 1731002..1731544 1 NC_009053.1 thiol:disulfide interchange protein DsbE 1731544 dsbE 4848702 dsbE Actinobacillus pleuropneumoniae serovar 5b str. L20 thiol:disulfide interchange protein DsbE YP_001054203.1 1731002 D 416269 CDS YP_001054204.1 126208979 4850075 1731549..1732016 1 NC_009053.1 hypothetical protein 1732016 4850075 APL_1515 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054204.1 1731549 D 416269 CDS YP_001054205.1 126208980 4849197 1732016..1732930 1 NC_009053.1 cytochrome c biogenesis factor-like protein 1732930 4849197 APL_1516 Actinobacillus pleuropneumoniae serovar 5b str. L20 cytochrome c biogenesis factor-like protein YP_001054205.1 1732016 D 416269 CDS YP_001054206.1 126208981 4850254 1733002..1733586 1 NC_009053.1 forms a trimer; related to eukaryotic protein gephyrin; functions during molybdenum cofactor biosynthesis; molybdenum cofactor biosynthesis protein MogA 1733586 mogA 4850254 mogA Actinobacillus pleuropneumoniae serovar 5b str. L20 molybdenum cofactor biosynthesis protein MogA YP_001054206.1 1733002 D 416269 CDS YP_001054207.1 126208982 4849241 1733706..1734044 1 NC_009053.1 nitrogen regulatory protein P-II 1734044 glnB 4849241 glnB Actinobacillus pleuropneumoniae serovar 5b str. L20 nitrogen regulatory protein P-II YP_001054207.1 1733706 D 416269 CDS YP_001054208.1 126208983 4849343 1734123..1734605 1 NC_009053.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis; lipoprotein signal peptidase 1734605 lspA 4849343 lspA Actinobacillus pleuropneumoniae serovar 5b str. L20 lipoprotein signal peptidase YP_001054208.1 1734123 D 416269 CDS YP_001054209.1 126208984 4849344 1734606..1735550 1 NC_009053.1 catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway; 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 1735550 ispH 4849344 ispH Actinobacillus pleuropneumoniae serovar 5b str. L20 4-hydroxy-3-methylbut-2-enyl diphosphate reductase YP_001054209.1 1734606 D 416269 CDS YP_001054210.1 126208985 4849986 1735550..1735798 1 NC_009053.1 hypothetical protein 1735798 4849986 APL_1521 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054210.1 1735550 D 416269 CDS YP_001054211.1 126208986 4850051 complement(1735867..1736466) 1 NC_009053.1 hypothetical protein 1736466 4850051 APL_1522 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054211.1 1735867 R 416269 CDS YP_001054212.1 126208987 4848479 complement(1736466..1738283) 1 NC_009053.1 coproporphyrinogen III oxidase 1738283 chuW 4848479 chuW Actinobacillus pleuropneumoniae serovar 5b str. L20 coproporphyrinogen III oxidase YP_001054212.1 1736466 R 416269 CDS YP_001054213.1 126208988 4848541 complement(1738440..1739057) 1 NC_009053.1 glutathione S-transferase 1739057 gst 4848541 gst Actinobacillus pleuropneumoniae serovar 5b str. L20 glutathione S-transferase YP_001054213.1 1738440 R 416269 CDS YP_001054214.1 126208989 4849221 complement(1739123..1740373) 1 NC_009053.1 diaminopimelate decarboxylase 1740373 lysA 4849221 lysA Actinobacillus pleuropneumoniae serovar 5b str. L20 diaminopimelate decarboxylase YP_001054214.1 1739123 R 416269 CDS YP_001054215.1 126208990 4850090 complement(1740789..1741133) 1 NC_009053.1 in conjunction with FrdC acts to anchor the catalytic components of the fumarate reductase to the cytoplasmic membrane; fumarate reductase subunit D 1741133 frdD 4850090 frdD Actinobacillus pleuropneumoniae serovar 5b str. L20 fumarate reductase subunit D YP_001054215.1 1740789 R 416269 CDS YP_001054216.1 126208991 4850135 complement(1741146..1741538) 1 NC_009053.1 part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase subunit C 1741538 frdC 4850135 frdC Actinobacillus pleuropneumoniae serovar 5b str. L20 fumarate reductase subunit C YP_001054216.1 1741146 R 416269 CDS YP_001054217.1 126208992 4850136 complement(1741547..1742281) 1 NC_009053.1 part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase iron-sulfur subunit 1742281 frdB 4850136 frdB Actinobacillus pleuropneumoniae serovar 5b str. L20 fumarate reductase iron-sulfur subunit YP_001054217.1 1741547 R 416269 CDS YP_001054218.1 126208993 4850125 complement(1742294..1744093) 1 NC_009053.1 part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase flavoprotein subunit 1744093 frdA 4850125 frdA Actinobacillus pleuropneumoniae serovar 5b str. L20 fumarate reductase flavoprotein subunit YP_001054218.1 1742294 R 416269 CDS YP_001054219.1 126208994 4849092 1744436..1745419 1 NC_009053.1 lysine--tRNA ligase beta chain; poxA; class II aminoacyl tRNA synthetase; catalyzes a two-step reaction; first charging a lysine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; lysyl-tRNA synthetase 1745419 poxA 4849092 poxA Actinobacillus pleuropneumoniae serovar 5b str. L20 lysyl-tRNA synthetase YP_001054219.1 1744436 D 416269 CDS YP_001054220.1 126208995 4848681 complement(1745501..1746325) 1 NC_009053.1 involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate; diaminopimelate epimerase 1746325 dapF 4848681 dapF Actinobacillus pleuropneumoniae serovar 5b str. L20 diaminopimelate epimerase YP_001054220.1 1745501 R 416269 CDS YP_001054221.1 126208996 4849397 1746506..1747828 1 NC_009053.1 functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to dcuB; anaerobic C4-dicarboxylate transporter 1747828 dcuB 4849397 dcuB Actinobacillus pleuropneumoniae serovar 5b str. L20 anaerobic C4-dicarboxylate transporter YP_001054221.1 1746506 D 416269 CDS YP_001054222.1 126208997 4850326 complement(1747900..1748271) 1 NC_009053.1 camphor resistance-like protein CrcB 1748271 crcB 4850326 crcB Actinobacillus pleuropneumoniae serovar 5b str. L20 camphor resistance-like protein CrcB YP_001054222.1 1747900 R 416269 CDS YP_001054223.1 126208998 4848839 complement(1748274..1749338) 1 NC_009053.1 transport system permease 1749338 4848839 APL_1534 Actinobacillus pleuropneumoniae serovar 5b str. L20 transport system permease YP_001054223.1 1748274 R 416269 CDS YP_001054224.1 126208999 4849027 1749433..1750542 1 NC_009053.1 catalyzes hydrolysis of 1,6-anhydro bond of anyhydro-N-acetylmuramic acid (anhMurNAc) and phosphorylates anhMurNAc to produce N-acetyl-muramate-6-phosphate; involved in murein recycling; anhydro-N-acetylmuramic acid kinase 1750542 anmK 4849027 anmK Actinobacillus pleuropneumoniae serovar 5b str. L20 anhydro-N-acetylmuramic acid kinase YP_001054224.1 1749433 D 416269 CDS YP_001054225.1 126209000 4849028 1750596..1751510 1 NC_009053.1 catalyzes the cleavage of the lactyl ether moiety of N-acetylmuramic acid-6-phosphate (MurNAc-6-P) to form N-acetylglucosamine-6-phosphate (GlcNAc-6-P) and lactate; involved in MurNAc dissimilation pathway; N-acetylmuramic acid 6-phosphate etherase 1751510 murQ 4849028 murQ Actinobacillus pleuropneumoniae serovar 5b str. L20 N-acetylmuramic acid 6-phosphate etherase YP_001054225.1 1750596 D 416269 CDS YP_001054226.1 126209001 4849675 complement(1751577..1752458) 1 NC_009053.1 methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype; 50S ribosomal protein L11 methyltransferase 1752458 prmA 4849675 prmA Actinobacillus pleuropneumoniae serovar 5b str. L20 50S ribosomal protein L11 methyltransferase YP_001054226.1 1751577 R 416269 CDS YP_001054227.1 126209002 4849809 complement(1752542..1753009) 1 NC_009053.1 acetyltransferase 1753009 4849809 APL_1538 Actinobacillus pleuropneumoniae serovar 5b str. L20 acetyltransferase YP_001054227.1 1752542 R 416269 CDS YP_001054228.1 126209003 4849524 complement(1753013..1753273) 1 NC_009053.1 hypothetical protein 1753273 4849524 APL_1539 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054228.1 1753013 R 416269 CDS YP_001054229.1 126209004 4849276 complement(1753394..1754854) 1 NC_009053.1 TldD-like protein 1754854 tldD 4849276 tldD Actinobacillus pleuropneumoniae serovar 5b str. L20 TldD-like protein YP_001054229.1 1753394 R 416269 CDS YP_001054230.1 126209005 4849337 1754984..1756243 1 NC_009053.1 tRNA(Ile)-lysidine synthase 1756243 tilS 4849337 tilS Actinobacillus pleuropneumoniae serovar 5b str. L20 tRNA(Ile)-lysidine synthase YP_001054230.1 1754984 D 416269 CDS YP_001054231.1 126209006 4849196 complement(1756562..1757455) 1 NC_009053.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; XerD specifically exchanges the bottom strands; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerD 1757455 xerD 4849196 xerD Actinobacillus pleuropneumoniae serovar 5b str. L20 site-specific tyrosine recombinase XerD YP_001054231.1 1756562 R 416269 CDS YP_001054232.1 126209007 4849596 complement(1764006..1764731) 1 NC_009053.1 UDP-N-acetyl-D-mannosaminuronic acid transferase 1764731 wecG 4849596 wecG Actinobacillus pleuropneumoniae serovar 5b str. L20 UDP-N-acetyl-D-mannosaminuronic acid transferase YP_001054232.1 1764006 R 416269 CDS YP_001054233.1 126209008 4850076 complement(1764715..1766049) 1 NC_009053.1 enterobacterial common antigen polymerase; common antigen polymerase 1766049 4850076 APL_1544 Actinobacillus pleuropneumoniae serovar 5b str. L20 common antigen polymerase YP_001054233.1 1764715 R 416269 CDS YP_001054234.1 126209009 4849404 complement(1766049..1767119) 1 NC_009053.1 catalyzes the synthesis of a lipid-linked intermediate involved in ECA synthesis; 4-alpha-L-fucosyltransferase 1767119 wecF 4849404 wecF Actinobacillus pleuropneumoniae serovar 5b str. L20 4-alpha-L-fucosyltransferase YP_001054234.1 1766049 R 416269 CDS YP_001054235.1 126209010 4849405 1767397..1769052 1 NC_009053.1 catalyzes the reduction of hydroxylamine to ammonia and water; hydroxylamine reductase 1769052 hcp 4849405 hcp Actinobacillus pleuropneumoniae serovar 5b str. L20 hydroxylamine reductase YP_001054235.1 1767397 D 416269 CDS YP_001054236.1 126209011 4848843 1769175..1770194 1 NC_009053.1 HCP oxidoreductase 1770194 hcr 4848843 hcr Actinobacillus pleuropneumoniae serovar 5b str. L20 HCP oxidoreductase YP_001054236.1 1769175 D 416269 CDS YP_001054237.1 126209012 4850319 complement(1770236..1771486) 1 NC_009053.1 hypothetical protein 1771486 4850319 APL_1548 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054237.1 1770236 R 416269 CDS YP_001054238.1 126209013 4848746 complement(1771474..1772619) 1 NC_009053.1 catalyzes the formation of dTDP-D-fucosamine from dTDP-4-oxo-6-deoxy-D-glucose in enterobacterial common antigen biosynthesis; TDP-4-oxo-6-deoxy-D-glucose transaminase 1772619 wecE 4848746 wecE Actinobacillus pleuropneumoniae serovar 5b str. L20 TDP-4-oxo-6-deoxy-D-glucose transaminase YP_001054238.1 1771474 R 416269 CDS YP_001054239.1 126209014 4849599 complement(1772626..1773249) 1 NC_009053.1 TDP-fucosamine acetyltransferase 1773249 wecD 4849599 wecD Actinobacillus pleuropneumoniae serovar 5b str. L20 TDP-fucosamine acetyltransferase YP_001054239.1 1772626 R 416269 CDS YP_001054240.1 126209015 4849827 complement(1773249..1774520) 1 NC_009053.1 catalyzes the oxidation of UDP-N-acetyl-D-mannosamine to UDP-N-acetylmannosaminuronic acid; UDP-N-acetyl-D-mannosamine dehydrogenase 1774520 wecC 4849827 wecC Actinobacillus pleuropneumoniae serovar 5b str. L20 UDP-N-acetyl-D-mannosamine dehydrogenase YP_001054240.1 1773249 R 416269 CDS YP_001054241.1 126209016 4850351 complement(1774599..1775678) 1 NC_009053.1 UDP-N-acetylglucosamine 2-epimerase 1775678 wecB 4850351 wecB Actinobacillus pleuropneumoniae serovar 5b str. L20 UDP-N-acetylglucosamine 2-epimerase YP_001054241.1 1774599 R 416269 CDS YP_001054242.1 126209017 4849307 complement(1775719..1776597) 1 NC_009053.1 hypothetical protein 1776597 4849307 APL_1553 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054242.1 1775719 R 416269 CDS YP_001054243.1 126209018 4849308 complement(1776632..1777705) 1 NC_009053.1 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase 1777705 wecA 4849308 wecA Actinobacillus pleuropneumoniae serovar 5b str. L20 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase YP_001054243.1 1776632 R 416269 CDS YP_001054244.1 126209019 4850218 1778004..1779284 1 NC_009053.1 Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway; glutamate-1-semialdehyde aminotransferase 1779284 hemL 4850218 hemL Actinobacillus pleuropneumoniae serovar 5b str. L20 glutamate-1-semialdehyde aminotransferase YP_001054244.1 1778004 D 416269 CDS YP_001054245.1 126209020 4848962 complement(1779339..1780406) 1 NC_009053.1 transport system permease 1780406 4848962 APL_1556 Actinobacillus pleuropneumoniae serovar 5b str. L20 transport system permease YP_001054245.1 1779339 R 416269 CDS YP_001054246.1 126209021 4850212 complement(1780426..1781955) 1 NC_009053.1 virulence factor-like MviN 1781955 mviN 4850212 mviN Actinobacillus pleuropneumoniae serovar 5b str. L20 virulence factor-like MviN YP_001054246.1 1780426 R 416269 CDS YP_001054247.1 126209022 4850402 1782389..1782652 1 NC_009053.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase; 30S ribosomal protein S20 1782652 rpsT 4850402 rpsT Actinobacillus pleuropneumoniae serovar 5b str. L20 30S ribosomal protein S20 YP_001054247.1 1782389 D 416269 CDS YP_001054248.1 126209023 4850067 complement(1782709..1784085) 1 NC_009053.1 involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain; potassium transporter peripheral membrane protein 1784085 trkA 4850067 trkA Actinobacillus pleuropneumoniae serovar 5b str. L20 potassium transporter peripheral membrane protein YP_001054248.1 1782709 R 416269 CDS YP_001054249.1 126209024 4849977 complement(1784135..1785433) 1 NC_009053.1 ribosomal RNA small subunit methyltransferase B 1785433 rsmB 4849977 rsmB Actinobacillus pleuropneumoniae serovar 5b str. L20 ribosomal RNA small subunit methyltransferase B YP_001054249.1 1784135 R 416269 CDS YP_001054250.1 126209025 4849301 complement(1785447..1787282) 1 NC_009053.1 selenocysteine-specific elongation factor 1787282 selB 4849301 selB Actinobacillus pleuropneumoniae serovar 5b str. L20 selenocysteine-specific elongation factor YP_001054250.1 1785447 R 416269 CDS YP_001054251.1 126209026 4849302 complement(1787279..1788664) 1 NC_009053.1 catalyzes the formation of selenocysteinyl-tRNA(Sec) from seryl-tRNA(Sec) and L-selenophosphate in selenoprotein biosynthesis; selenocysteine synthase 1788664 selA 4849302 selA Actinobacillus pleuropneumoniae serovar 5b str. L20 selenocysteine synthase YP_001054251.1 1787279 R 416269 CDS YP_001054252.1 126209027 4849677 1788841..1789284 1 NC_009053.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin 1789284 mioC 4849677 mioC Actinobacillus pleuropneumoniae serovar 5b str. L20 flavodoxin YP_001054252.1 1788841 D 416269 CDS YP_001054253.1 126209028 4849143 complement(1790122..1791579) 1 NC_009053.1 L-xylulose kinase 1791579 lyx 4849143 lyx Actinobacillus pleuropneumoniae serovar 5b str. L20 L-xylulose kinase YP_001054253.1 1790122 R 416269 CDS YP_001054254.1 126209029 4849680 complement(1791594..1792037) 1 NC_009053.1 gluconolactonase 1792037 4849680 APL_1565 Actinobacillus pleuropneumoniae serovar 5b str. L20 gluconolactonase YP_001054254.1 1791594 R 416269 CDS YP_001054255.1 126209030 4849277 complement(1792412..1792594) 1 NC_009053.1 hypothetical protein 1792594 4849277 APL_1566 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054255.1 1792412 R 416269 CDS YP_001054256.1 126209031 4849278 complement(1793088..1795895) 1 NC_009053.1 transferrin-binding protein 1 Tbp1 1795895 tbpA 4849278 tbpA Actinobacillus pleuropneumoniae serovar 5b str. L20 transferrin-binding protein 1 Tbp1 YP_001054256.1 1793088 R 416269 CDS YP_001054257.1 126209032 4850335 complement(1795909..1797552) 1 NC_009053.1 transferrin-binding protein 1797552 tbpB 4850335 tbpB Actinobacillus pleuropneumoniae serovar 5b str. L20 transferrin-binding protein YP_001054257.1 1795909 R 416269 CDS YP_001054258.1 126209033 4848773 complement(1797580..1797990) 1 NC_009053.1 biopolymer transport ExbD protein 1797990 exbD 4848773 exbD Actinobacillus pleuropneumoniae serovar 5b str. L20 biopolymer transport ExbD protein YP_001054258.1 1797580 R 416269 CDS YP_001054259.1 126209034 4849793 complement(1797990..1798658) 1 NC_009053.1 biopolymer transport ExbB protein 1798658 exbB 4849793 exbB Actinobacillus pleuropneumoniae serovar 5b str. L20 biopolymer transport ExbB protein YP_001054259.1 1797990 R 416269 CDS YP_001054260.1 126209035 4849115 complement(1798680..1799420) 1 NC_009053.1 pubmed:14742511; hypothetical protein 1799420 tonB1 4849115 tonB1 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054260.1 1798680 R 416269 CDS YP_001054261.1 126209036 4849929 complement(1799696..1799944) 1 NC_009053.1 hypothetical protein 1799944 4849929 APL_1572 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054261.1 1799696 R 416269 CDS YP_001054262.1 126209037 4850062 complement(1800111..1800818) 1 NC_009053.1 2,3-diketo-L-gulonate reductase 1800818 4850062 APL_1573 Actinobacillus pleuropneumoniae serovar 5b str. L20 2,3-diketo-L-gulonate reductase YP_001054262.1 1800111 R 416269 CDS YP_001054263.1 126209038 4850522 1801340..1801882 1 NC_009053.1 hypothetical protein 1801882 4850522 APL_1574 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054263.1 1801340 D 416269 CDS YP_001054264.1 126209039 4850523 complement(1801954..1802508) 1 NC_009053.1 hypothetical protein 1802508 4850523 APL_1575 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054264.1 1801954 R 416269 CDS YP_001054265.1 126209040 4848974 complement(1802526..1803461) 1 NC_009053.1 arabinose-5-phosphate isomerase 1803461 kpsF 4848974 kpsF Actinobacillus pleuropneumoniae serovar 5b str. L20 arabinose-5-phosphate isomerase YP_001054265.1 1802526 R 416269 CDS YP_001054266.1 126209041 4850210 complement(1803473..1804231) 1 NC_009053.1 CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS; 3-deoxy-manno-octulosonate cytidylyltransferase 1804231 kdsB 4850210 kdsB Actinobacillus pleuropneumoniae serovar 5b str. L20 3-deoxy-manno-octulosonate cytidylyltransferase YP_001054266.1 1803473 R 416269 CDS YP_001054267.1 126209042 4848960 complement(1804277..1805137) 1 NC_009053.1 catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis; 2-dehydro-3-deoxyphosphooctonate aldolase 1805137 kdsA 4848960 kdsA Actinobacillus pleuropneumoniae serovar 5b str. L20 2-dehydro-3-deoxyphosphooctonate aldolase YP_001054267.1 1804277 R 416269 CDS YP_001054268.1 126209043 4849478 complement(1805186..1806334) 1 NC_009053.1 pubmed:9632602; region 2 capsular polysaccharide biosynthesis protein 1806334 cps5C 4849478 cps5C Actinobacillus pleuropneumoniae serovar 5b str. L20 region 2 capsular polysaccharide biosynthesis protein YP_001054268.1 1805186 R 416269 CDS YP_001054269.1 126209044 4849020 complement(1806349..1807929) 1 NC_009053.1 pubmed:9632602; region 2 capsular polysaccharide biosynthesis protein 1807929 cps5B 4849020 cps5B Actinobacillus pleuropneumoniae serovar 5b str. L20 region 2 capsular polysaccharide biosynthesis protein YP_001054269.1 1806349 R 416269 CDS YP_001054270.1 126209045 4849402 complement(1807932..1808897) 1 NC_009053.1 pubmed:9632602; glycosyltransferase 1808897 4849402 APL_1581 Actinobacillus pleuropneumoniae serovar 5b str. L20 glycosyltransferase YP_001054270.1 1807932 R 416269 CDS YP_001054271.1 126209046 4849025 1809226..1810410 1 NC_009053.1 pubmed:9169799; capsule polysaccharide export protein 1810410 cpxD 4849025 cpxD Actinobacillus pleuropneumoniae serovar 5b str. L20 capsule polysaccharide export protein YP_001054271.1 1809226 D 416269 CDS YP_001054272.1 126209047 4849026 1810436..1811593 1 NC_009053.1 pubmed:9169799; capsule polysaccharide export inner-membrane protein 1811593 cpxC 4849026 cpxC Actinobacillus pleuropneumoniae serovar 5b str. L20 capsule polysaccharide export inner-membrane protein YP_001054272.1 1810436 D 416269 CDS YP_001054273.1 126209048 4850217 1811593..1812390 1 NC_009053.1 pubmed:9169799; capsule polysaccharide export inner-membrane protein 1812390 cpxB 4850217 cpxB Actinobacillus pleuropneumoniae serovar 5b str. L20 capsule polysaccharide export inner-membrane protein YP_001054273.1 1811593 D 416269 CDS YP_001054274.1 126209049 4848980 1812387..1813037 1 NC_009053.1 pubmed:9169799; ATP-binding protein 1813037 cpxA 4848980 cpxA Actinobacillus pleuropneumoniae serovar 5b str. L20 ATP-binding protein YP_001054274.1 1812387 D 416269 CDS YP_001054275.1 126209050 4848837 complement(1813385..1814857) 1 NC_009053.1 contains 2 ATP-binding cassettes; involved in the transport of molybdenum; molybdenum transport ATP-binding protein ModF 1814857 modF 4848837 modF Actinobacillus pleuropneumoniae serovar 5b str. L20 molybdenum transport ATP-binding protein ModF YP_001054275.1 1813385 R 416269 CDS YP_001054276.1 126209051 4850457 complement(1814950..1815900) 1 NC_009053.1 modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth; methionyl-tRNA formyltransferase 1815900 fmt 4850457 fmt Actinobacillus pleuropneumoniae serovar 5b str. L20 methionyl-tRNA formyltransferase YP_001054276.1 1814950 R 416269 CDS YP_001054277.1 126209052 4848788 complement(1816063..1817013) 1 NC_009053.1 TRAP transporter solute receptor 1817013 4848788 APL_1588 Actinobacillus pleuropneumoniae serovar 5b str. L20 TRAP transporter solute receptor YP_001054277.1 1816063 R 416269 CDS YP_001054278.1 126209053 4849120 1817075..1817803 1 NC_009053.1 hypothetical protein 1817803 4849120 APL_1589 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054278.1 1817075 D 416269 CDS YP_001054279.1 126209054 4849006 1817884..1819362 1 NC_009053.1 Trk system potassium uptake protein TrkH 1819362 trkH 4849006 trkH Actinobacillus pleuropneumoniae serovar 5b str. L20 Trk system potassium uptake protein TrkH YP_001054279.1 1817884 D 416269 CDS YP_001054280.1 126209055 4849007 1819377..1819904 1 NC_009053.1 hypothetical protein 1819904 4849007 APL_1591 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054280.1 1819377 D 416269 CDS YP_001054281.1 126209056 4849008 1820008..1820397 1 NC_009053.1 forms homopentamer; channel that opens in response to pressure or hypoosmotic shock; large-conductance mechanosensitive channel 1820397 mscL 4849008 mscL Actinobacillus pleuropneumoniae serovar 5b str. L20 large-conductance mechanosensitive channel YP_001054281.1 1820008 D 416269 CDS YP_001054282.1 126209057 4849701 complement(1820527..1821519) 1 NC_009053.1 catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group; lipoyl synthase 1821519 lipA 4849701 lipA Actinobacillus pleuropneumoniae serovar 5b str. L20 lipoyl synthase YP_001054282.1 1820527 R 416269 CDS YP_001054283.1 126209058 4849594 complement(1821631..1822287) 1 NC_009053.1 lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein; lipoate-protein ligase B 1822287 lipB 4849594 lipB Actinobacillus pleuropneumoniae serovar 5b str. L20 lipoate-protein ligase B YP_001054283.1 1821631 R 416269 CDS YP_001054284.1 126209059 4849800 complement(1822319..1822618) 1 NC_009053.1 hypothetical protein 1822618 4849800 APL_1595 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054284.1 1822319 R 416269 CDS YP_001054285.1 126209060 4849686 complement(1822752..1823930) 1 NC_009053.1 D-alanyl-D-alanine carboxypeptidase 1823930 dacA 4849686 dacA Actinobacillus pleuropneumoniae serovar 5b str. L20 D-alanyl-D-alanine carboxypeptidase YP_001054285.1 1822752 R 416269 CDS YP_001054286.1 126209061 4850214 complement(1824026..1824589) 1 NC_009053.1 rare lipoprotein A RlpA-like protein 1824589 4850214 APL_1597 Actinobacillus pleuropneumoniae serovar 5b str. L20 rare lipoprotein A RlpA-like protein YP_001054286.1 1824026 R 416269 CDS YP_001054287.1 126209062 4849312 complement(1824764..1825888) 1 NC_009053.1 rod shape-determining protein 1825888 mrdB 4849312 mrdB Actinobacillus pleuropneumoniae serovar 5b str. L20 rod shape-determining protein YP_001054287.1 1824764 R 416269 CDS YP_001054288.1 126209063 4849313 complement(1825881..1827842) 1 NC_009053.1 penicillin-binding protein 2 1827842 mrdA 4849313 mrdA Actinobacillus pleuropneumoniae serovar 5b str. L20 penicillin-binding protein 2 YP_001054288.1 1825881 R 416269 CDS YP_001054289.1 126209064 4849303 complement(1827924..1828391) 1 NC_009053.1 SPOUT methyltransferase family protein; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA; rRNA large subunit methyltransferase 1828391 4849303 APL_1600 Actinobacillus pleuropneumoniae serovar 5b str. L20 rRNA large subunit methyltransferase YP_001054289.1 1827924 R 416269 CDS YP_001054290.1 126209065 4850082 complement(1828414..1828728) 1 NC_009053.1 hypothetical protein 1828728 4850082 APL_1601 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054290.1 1828414 R 416269 CDS YP_001054291.1 126209066 4849408 complement(1828954..1831548) 1 NC_009053.1 This protein performs the mismatch recognition step during the DNA repair process; DNA mismatch repair protein MutS 1831548 mutS 4849408 mutS Actinobacillus pleuropneumoniae serovar 5b str. L20 DNA mismatch repair protein MutS YP_001054291.1 1828954 R 416269 CDS YP_001054292.1 126209067 4849251 complement(1831714..1832463) 1 NC_009053.1 amino acid ABC transporter ATP-binding protein 1832463 4849251 APL_1603 Actinobacillus pleuropneumoniae serovar 5b str. L20 amino acid ABC transporter ATP-binding protein YP_001054292.1 1831714 R 416269 CDS YP_001054293.1 126209068 4849463 complement(1832485..1833168) 1 NC_009053.1 amino acid ABC transporter permease 1833168 4849463 APL_1604 Actinobacillus pleuropneumoniae serovar 5b str. L20 amino acid ABC transporter permease YP_001054293.1 1832485 R 416269 CDS YP_001054294.1 126209069 4849629 complement(1833350..1834648) 1 NC_009053.1 hypothetical protein 1834648 4849629 APL_1605 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054294.1 1833350 R 416269 CDS YP_001054295.1 126209070 4850454 1834920..1835414 1 NC_009053.1 regulator of cell morphogenesis and NO signaling 1835414 4850454 APL_1606 Actinobacillus pleuropneumoniae serovar 5b str. L20 regulator of cell morphogenesis and NO signaling YP_001054295.1 1834920 D 416269 CDS YP_001054296.1 126209071 4850455 complement(1835493..1835822) 1 NC_009053.1 drug resistance protein 1835822 4850455 APL_1607 Actinobacillus pleuropneumoniae serovar 5b str. L20 drug resistance protein YP_001054296.1 1835493 R 416269 CDS YP_001054297.1 126209072 4850461 complement(1835910..1836200) 1 NC_009053.1 hypothetical protein 1836200 4850461 APL_1608 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054297.1 1835910 R 416269 CDS YP_001054298.1 126209073 4850563 complement(1836354..1836914) 1 NC_009053.1 hypothetical protein 1836914 4850563 APL_1609 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054298.1 1836354 R 416269 CDS YP_001054299.1 126209074 4848770 complement(1837087..1837380) 1 NC_009053.1 hypothetical protein 1837380 4848770 APL_1610 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054299.1 1837087 R 416269 CDS YP_001054300.1 126209075 4849315 complement(1837396..1838208) 1 NC_009053.1 urease accessory protein UreD 1838208 ureD 4849315 ureD Actinobacillus pleuropneumoniae serovar 5b str. L20 urease accessory protein UreD YP_001054300.1 1837396 R 416269 CDS YP_001054301.1 126209076 4849436 complement(1838377..1839012) 1 NC_009053.1 urease accessory protein UreG 1839012 ureG 4849436 ureG Actinobacillus pleuropneumoniae serovar 5b str. L20 urease accessory protein UreG YP_001054301.1 1838377 R 416269 CDS YP_001054302.1 126209077 4848971 complement(1839033..1839716) 1 NC_009053.1 urease accessory protein UreF 1839716 ureF 4848971 ureF Actinobacillus pleuropneumoniae serovar 5b str. L20 urease accessory protein UreF YP_001054302.1 1839033 R 416269 CDS YP_001054303.1 126209078 4849828 complement(1839728..1840306) 1 NC_009053.1 involved in the assembly of the urease metallocenter; possible nickel donor; urease accessory protein UreE 1840306 ureE 4849828 ureE Actinobacillus pleuropneumoniae serovar 5b str. L20 urease accessory protein UreE YP_001054303.1 1839728 R 416269 CDS YP_001054304.1 126209079 4849829 complement(1840422..1841039) 1 NC_009053.1 glutathione S-transferase 1841039 gst 4849829 gst Actinobacillus pleuropneumoniae serovar 5b str. L20 glutathione S-transferase YP_001054304.1 1840422 R 416269 CDS YP_001054305.1 126209080 4850391 complement(1841163..1842881) 1 NC_009053.1 ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alpha) and 3 ureAB (gamma/beta) subunits; urease subunit alpha 1842881 ureC 4850391 ureC Actinobacillus pleuropneumoniae serovar 5b str. L20 urease subunit alpha YP_001054305.1 1841163 R 416269 CDS YP_001054306.1 126209081 4848933 complement(1842892..1843197) 1 NC_009053.1 ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori and Yersinia enterocolitica the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 UreC (alpha) and 3 UreAB (gamma/beta); in Brucella suis the urease encoded by this operon (one of two urease-encoding operons found in its genome) is involved with urease activity, optimum growth, resistance to low-pH killing in-vitro and persistence in-vivo, while the other operon does not seem to be active; urease subunit beta 1843197 ureB 4848933 ureB Actinobacillus pleuropneumoniae serovar 5b str. L20 urease subunit beta YP_001054306.1 1842892 R 416269 CDS YP_001054307.1 126209082 4850336 complement(1843387..1843689) 1 NC_009053.1 UreA, with UreB and UreC catalyzes the hydrolysis of urea into ammonia and carbon dioxide; nickel metalloenzyme; accessory proteins UreD, UreE, UreF, and UreG are necessary for assembly of the metallocenter; urease subunit gamma 1843689 ureA 4850336 ureA Actinobacillus pleuropneumoniae serovar 5b str. L20 urease subunit gamma YP_001054307.1 1843387 R 416269 CDS YP_001054308.1 126209083 4850193 complement(1843761..1844576) 1 NC_009053.1 urea transport protein ApUT 1844576 utp 4850193 utp Actinobacillus pleuropneumoniae serovar 5b str. L20 urea transport protein ApUT YP_001054308.1 1843761 R 416269 CDS YP_001054309.1 126209084 4850447 complement(1844688..1845317) 1 NC_009053.1 ABC transporter ATP-binding protein 1845317 cbiO 4850447 cbiO Actinobacillus pleuropneumoniae serovar 5b str. L20 ABC transporter ATP-binding protein YP_001054309.1 1844688 R 416269 CDS YP_001054310.1 126209085 4849178 complement(1845340..1845957) 1 NC_009053.1 ABC transport permease protein CbiQ 1845957 cbiQ 4849178 cbiQ Actinobacillus pleuropneumoniae serovar 5b str. L20 ABC transport permease protein CbiQ YP_001054310.1 1845340 R 416269 CDS YP_001054311.1 126209086 4849796 complement(1845964..1846572) 1 NC_009053.1 catalyzes the ATP-dependent transport of cobalt; cobalt transport protein CbiM 1846572 cbiM 4849796 cbiM Actinobacillus pleuropneumoniae serovar 5b str. L20 cobalt transport protein CbiM YP_001054311.1 1845964 R 416269 CDS YP_001054312.1 126209087 4849797 complement(1846573..1847055) 1 NC_009053.1 cytoplasmic membrane protein CbiL 1847055 cbiL 4849797 cbiL Actinobacillus pleuropneumoniae serovar 5b str. L20 cytoplasmic membrane protein CbiL YP_001054312.1 1846573 R 416269 CDS YP_001054313.1 126209088 4849601 complement(1847055..1847741) 1 NC_009053.1 periplasmic binding protein CbiK 1847741 cbiK 4849601 cbiK Actinobacillus pleuropneumoniae serovar 5b str. L20 periplasmic binding protein CbiK YP_001054313.1 1847055 R 416269 CDS YP_001054314.1 126209089 4849096 1848084..1848839 1 NC_009053.1 LysR-type transcriptional regulator 1848839 apuR 4849096 apuR Actinobacillus pleuropneumoniae serovar 5b str. L20 LysR-type transcriptional regulator YP_001054314.1 1848084 D 416269 CDS YP_001054315.1 126209090 4849074 complement(1848918..1849379) 1 NC_009053.1 hypothetical protein 1849379 4849074 APL_1626 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054315.1 1848918 R 416269 CDS YP_001054316.1 126209091 4849153 complement(1849607..1851472) 1 NC_009053.1 hypothetical protein 1851472 4849153 APL_1627 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054316.1 1849607 R 416269 CDS YP_001054317.1 126209092 4850043 complement(1851533..1852057) 1 NC_009053.1 Acts as a repressor of the mtlAD operon; mannitol repressor protein 1852057 mtlR 4850043 mtlR Actinobacillus pleuropneumoniae serovar 5b str. L20 mannitol repressor protein YP_001054317.1 1851533 R 416269 CDS YP_001054318.1 126209093 4849415 complement(1852057..1853196) 1 NC_009053.1 mannitol-1-phosphate 5-dehydrogenase 1853196 mtlD 4849415 mtlD Actinobacillus pleuropneumoniae serovar 5b str. L20 mannitol-1-phosphate 5-dehydrogenase YP_001054318.1 1852057 R 416269 CDS YP_001054319.1 126209094 4848748 complement(1853283..1855172) 1 NC_009053.1 Includes: Mannitol permease IIC component; Mannitol-specific phosphotransferase enzyme IIB component; Mannitol-specific phosphotransferase enzyme IIA component; PTS system mannitol-specific transporter subunit IICBA 1855172 mtlA 4848748 mtlA Actinobacillus pleuropneumoniae serovar 5b str. L20 PTS system mannitol-specific transporter subunit IICBA YP_001054319.1 1853283 R 416269 CDS YP_001054320.1 126209095 4848749 complement(1855480..1857312) 1 NC_009053.1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source; glucosamine--fructose-6-phosphate aminotransferase 1857312 glmS 4848749 glmS Actinobacillus pleuropneumoniae serovar 5b str. L20 glucosamine--fructose-6-phosphate aminotransferase YP_001054320.1 1855480 R 416269 CDS YP_001054321.1 126209096 4848867 complement(1857436..1858194) 1 NC_009053.1 sugar metabolism transcriptional regulator 1858194 4848867 APL_1632 Actinobacillus pleuropneumoniae serovar 5b str. L20 sugar metabolism transcriptional regulator YP_001054321.1 1857436 R 416269 CDS YP_001054322.1 126209097 4849923 complement(1858332..1858532) 1 NC_009053.1 hypothetical protein 1858532 4849923 APL_1633 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054322.1 1858332 R 416269 CDS YP_001054323.1 126209098 4849851 complement(1858631..1859623) 1 NC_009053.1 glycosyltransferase 1859623 4849851 APL_1634 Actinobacillus pleuropneumoniae serovar 5b str. L20 glycosyltransferase YP_001054323.1 1858631 R 416269 CDS YP_001054324.1 126209099 4849812 complement(1859672..1861534) 1 NC_009053.1 adhesin processing HmwC-like protein 1861534 4849812 APL_1635 Actinobacillus pleuropneumoniae serovar 5b str. L20 adhesin processing HmwC-like protein YP_001054324.1 1859672 R 416269 CDS YP_001054325.1 126209100 4849937 complement(1861550..1862881) 1 NC_009053.1 catalyzes the methylthiolation of an aspartic acid residue of the S12 protein of the 30S ribosomal subunit; 30S ribosomal protein S12 methylthiotransferase 1862881 rimO 4849937 rimO Actinobacillus pleuropneumoniae serovar 5b str. L20 30S ribosomal protein S12 methylthiotransferase YP_001054325.1 1861550 R 416269 CDS YP_001054326.1 126209101 4850348 complement(1863055..1863753) 1 NC_009053.1 MTA/SAH nucleosidase 1863753 mtn 4850348 mtn Actinobacillus pleuropneumoniae serovar 5b str. L20 MTA/SAH nucleosidase YP_001054326.1 1863055 R 416269 CDS YP_001054327.1 126209102 4849714 complement(1863753..1864460) 1 NC_009053.1 thiol disulfide oxidoreductase 1864460 dsbA_2 4849714 dsbA_2 Actinobacillus pleuropneumoniae serovar 5b str. L20 thiol disulfide oxidoreductase YP_001054327.1 1863753 R 416269 CDS YP_001054328.1 126209103 4849715 complement(1864527..1864748) 1 NC_009053.1 hypothetical protein 1864748 slyX 4849715 slyX Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054328.1 1864527 R 416269 CDS YP_001054329.1 126209104 4849158 1864839..1865570 1 NC_009053.1 FKBP-type peptidyl-prolyl cis-trans isomerase 1865570 fkpA 4849158 fkpA Actinobacillus pleuropneumoniae serovar 5b str. L20 FKBP-type peptidyl-prolyl cis-trans isomerase YP_001054329.1 1864839 D 416269 CDS YP_001054330.1 126209105 4849702 1865682..1866341 1 NC_009053.1 hypothetical protein 1866341 4849702 APL_1641 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054330.1 1865682 D 416269 CDS YP_001054331.1 126209106 4849841 1866341..1866718 1 NC_009053.1 in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs; sulfur transfer complex subunit TusD 1866718 tusD 4849841 tusD Actinobacillus pleuropneumoniae serovar 5b str. L20 sulfur transfer complex subunit TusD YP_001054331.1 1866341 D 416269 CDS YP_001054332.1 126209107 4850350 1866721..1867092 1 NC_009053.1 hypothetical protein 1867092 4850350 APL_1643 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054332.1 1866721 D 416269 CDS YP_001054333.1 126209108 4850134 1867105..1867374 1 NC_009053.1 hypothetical protein 1867374 4850134 APL_1644 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054333.1 1867105 D 416269 CDS YP_001054334.1 126209109 4848768 complement(1873346..1873765) 1 NC_009053.1 part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane; F0F1 ATP synthase subunit epsilon 1873765 atpC 4848768 atpC Actinobacillus pleuropneumoniae serovar 5b str. L20 F0F1 ATP synthase subunit epsilon YP_001054334.1 1873346 R 416269 CDS YP_001054335.1 126209110 4849292 complement(1873805..1875178) 1 NC_009053.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit; F0F1 ATP synthase subunit beta 1875178 atpD 4849292 atpD Actinobacillus pleuropneumoniae serovar 5b str. L20 F0F1 ATP synthase subunit beta YP_001054335.1 1873805 R 416269 CDS YP_001054336.1 126209111 4850085 complement(1875192..1876058) 1 NC_009053.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit; F0F1 ATP synthase subunit gamma 1876058 atpG 4850085 atpG Actinobacillus pleuropneumoniae serovar 5b str. L20 F0F1 ATP synthase subunit gamma YP_001054336.1 1875192 R 416269 CDS YP_001054337.1 126209112 4850203 complement(1876081..1877622) 1 NC_009053.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit; F0F1 ATP synthase subunit alpha 1877622 atpA 4850203 atpA Actinobacillus pleuropneumoniae serovar 5b str. L20 F0F1 ATP synthase subunit alpha YP_001054337.1 1876081 R 416269 CDS YP_001054338.1 126209113 4850346 complement(1877635..1878168) 1 NC_009053.1 Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex; F0F1 ATP synthase subunit delta 1878168 atpH 4850346 atpH Actinobacillus pleuropneumoniae serovar 5b str. L20 F0F1 ATP synthase subunit delta YP_001054338.1 1877635 R 416269 CDS YP_001054339.1 126209114 4850234 complement(1878182..1878652) 1 NC_009053.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.; F0F1 ATP synthase subunit B 1878652 atpF 4850234 atpF Actinobacillus pleuropneumoniae serovar 5b str. L20 F0F1 ATP synthase subunit B YP_001054339.1 1878182 R 416269 CDS YP_001054340.1 126209115 4848669 complement(1878712..1878966) 1 NC_009053.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0; F0F1 ATP synthase subunit C 1878966 atpE 4848669 atpE Actinobacillus pleuropneumoniae serovar 5b str. L20 F0F1 ATP synthase subunit C YP_001054340.1 1878712 R 416269 CDS YP_001054341.1 126209116 4849825 complement(1879085..1879873) 1 NC_009053.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0; F0F1 ATP synthase subunit A 1879873 atpB 4849825 atpB Actinobacillus pleuropneumoniae serovar 5b str. L20 F0F1 ATP synthase subunit A YP_001054341.1 1879085 R 416269 CDS YP_001054342.1 126209117 4849826 complement(1879898..1880281) 1 NC_009053.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation; F0F1 ATP synthase subunit I 1880281 4849826 APL_1653 Actinobacillus pleuropneumoniae serovar 5b str. L20 F0F1 ATP synthase subunit I YP_001054342.1 1879898 R 416269 CDS YP_001054343.1 126209118 4848985 complement(1880642..1881259) 1 NC_009053.1 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA; 16S rRNA methyltransferase GidB 1881259 gidB 4848985 gidB Actinobacillus pleuropneumoniae serovar 5b str. L20 16S rRNA methyltransferase GidB YP_001054343.1 1880642 R 416269 CDS YP_001054344.1 126209119 4850207 complement(1881359..1883251) 1 NC_009053.1 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs; tRNA uridine 5-carboxymethylaminomethyl modification protein GidA 1883251 gidA 4850207 gidA Actinobacillus pleuropneumoniae serovar 5b str. L20 tRNA uridine 5-carboxymethylaminomethyl modification protein GidA YP_001054344.1 1881359 R 416269 CDS YP_001054345.1 126209120 4849946 1883701..1884513 1 NC_009053.1 hypothetical protein 1884513 4849946 APL_1656 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054345.1 1883701 D 416269 CDS YP_001054346.1 126209121 4849177 complement(1884563..1885345) 1 NC_009053.1 amino-acid ABC transporter-binding protein 1885345 4849177 APL_1657 Actinobacillus pleuropneumoniae serovar 5b str. L20 amino-acid ABC transporter-binding protein YP_001054346.1 1884563 R 416269 CDS YP_001054347.1 126209122 4849013 complement(1885558..1886034) 1 NC_009053.1 hypothetical protein 1886034 4849013 APL_1658 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054347.1 1885558 R 416269 CDS YP_001054348.1 126209123 4850356 complement(1886037..1886414) 1 NC_009053.1 hypothetical protein 1886414 4850356 APL_1659 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054348.1 1886037 R 416269 CDS YP_001054349.1 126209124 4849822 complement(1886502..1887329) 1 NC_009053.1 mannose permease IID component 1887329 4849822 APL_1660 Actinobacillus pleuropneumoniae serovar 5b str. L20 mannose permease IID component YP_001054349.1 1886502 R 416269 CDS YP_001054350.1 126209125 4849823 complement(1887340..1888134) 1 NC_009053.1 mannose permease IIC component 1888134 4849823 APL_1661 Actinobacillus pleuropneumoniae serovar 5b str. L20 mannose permease IIC component YP_001054350.1 1887340 R 416269 CDS YP_001054351.1 126209126 4848953 complement(1888149..1889117) 1 NC_009053.1 Includes: Mannose-specific phosphotransferase enzyme IIA component; Mannose-specific phosphotransferase enzyme IIB component; PTS system mannose-specific transporter subunit IIAB 1889117 4848953 APL_1662 Actinobacillus pleuropneumoniae serovar 5b str. L20 PTS system mannose-specific transporter subunit IIAB YP_001054351.1 1888149 R 416269 CDS YP_001054352.1 126209127 4848833 complement(1889293..1890105) 1 NC_009053.1 transposase-like protein 1890105 4848833 APL_1663 Actinobacillus pleuropneumoniae serovar 5b str. L20 transposase-like protein YP_001054352.1 1889293 R 416269 CDS YP_001054353.1 126209128 4850031 complement(1890117..1890626) 1 NC_009053.1 transposase 1890626 4850031 APL_1664 Actinobacillus pleuropneumoniae serovar 5b str. L20 transposase YP_001054353.1 1890117 R 416269 CDS YP_001054354.1 126209129 4848952 complement(1890708..1892057) 1 NC_009053.1 gluconate permease 1892057 gntP_1 4848952 gntP_1 Actinobacillus pleuropneumoniae serovar 5b str. L20 gluconate permease YP_001054354.1 1890708 R 416269 CDS YP_001054355.1 126209130 4848711 1892235..1892750 1 NC_009053.1 thermosensitive gluconokinase 1892750 gntK 4848711 gntK Actinobacillus pleuropneumoniae serovar 5b str. L20 thermosensitive gluconokinase YP_001054355.1 1892235 D 416269 CDS YP_001054356.1 126209131 4848900 complement(1892822..1893820) 1 NC_009053.1 HTH-type transcriptional regulator 1893820 gntR 4848900 gntR Actinobacillus pleuropneumoniae serovar 5b str. L20 HTH-type transcriptional regulator YP_001054356.1 1892822 R 416269 CDS YP_001054357.1 126209132 4850343 1893943..1894932 1 NC_009053.1 ribose operon repressor 1894932 rbsR 4850343 rbsR Actinobacillus pleuropneumoniae serovar 5b str. L20 ribose operon repressor YP_001054357.1 1893943 D 416269 CDS YP_001054358.1 126209133 4850344 1895053..1895472 1 NC_009053.1 cytoplasmic mutarotase that catalyzes the conversion between beta-pyran and beta-furan forms of D-ribose; RbsD is required for efficient ribose utilization in E. coli; rbsD-mutant E. coli strains are unable to use ribose as a sole carbon source; D-ribose pyranase 1895472 rbsD 4850344 rbsD Actinobacillus pleuropneumoniae serovar 5b str. L20 D-ribose pyranase YP_001054358.1 1895053 D 416269 CDS YP_001054359.1 126209134 4848659 1895485..1896966 1 NC_009053.1 with RbsBCD acts to import ribose into the cell; RbsA contains 2 ATP-binding domain; D-ribose transporter ATP-binding protein 1896966 rbsA 4848659 rbsA Actinobacillus pleuropneumoniae serovar 5b str. L20 D-ribose transporter ATP-binding protein YP_001054359.1 1895485 D 416269 CDS YP_001054360.1 126209135 4849671 1897019..1897978 1 NC_009053.1 functions to transport ribose at high affinity; forms a complex with RbsA2C2B; ribose ABC transporter permease 1897978 rbsC 4849671 rbsC Actinobacillus pleuropneumoniae serovar 5b str. L20 ribose ABC transporter permease YP_001054360.1 1897019 D 416269 CDS YP_001054361.1 126209136 4850077 1898002..1898874 1 NC_009053.1 periplasmic substrate-binding component of the ATP-dependent ribose transport system; D-ribose transporter subunit RbsB 1898874 rbsB 4850077 rbsB Actinobacillus pleuropneumoniae serovar 5b str. L20 D-ribose transporter subunit RbsB YP_001054361.1 1898002 D 416269 CDS YP_001054362.1 126209137 4848967 1898947..1899858 1 NC_009053.1 catalyzes the formation of D-ribose 5-phosphate from ribose; ribokinase 1899858 rbsK 4848967 rbsK Actinobacillus pleuropneumoniae serovar 5b str. L20 ribokinase YP_001054362.1 1898947 D 416269 CDS YP_001054363.1 126209138 4849184 1900092..1902509 1 NC_009053.1 anaerobic dimethyl sulfoxide reductase subunit A 1902509 dmsA 4849184 dmsA Actinobacillus pleuropneumoniae serovar 5b str. L20 anaerobic dimethyl sulfoxide reductase subunit A YP_001054363.1 1900092 D 416269 CDS YP_001054364.1 126209139 4849409 1902519..1903136 1 NC_009053.1 anaerobic dimethyl sulfoxide reductase subunit B 1903136 dmsB 4849409 dmsB Actinobacillus pleuropneumoniae serovar 5b str. L20 anaerobic dimethyl sulfoxide reductase subunit B YP_001054364.1 1902519 D 416269 CDS YP_001054365.1 126209140 4849011 1903138..1903971 1 NC_009053.1 anaerobic dimethyl sulfoxide reductase subunit C 1903971 dmsC 4849011 dmsC Actinobacillus pleuropneumoniae serovar 5b str. L20 anaerobic dimethyl sulfoxide reductase subunit C YP_001054365.1 1903138 D 416269 CDS YP_001054366.1 126209141 4849012 1904027..1904632 1 NC_009053.1 binds to the twin-arginine signal peptides of certain proteins, including dimethylsulfoxide reductase and trimethylamine N-oxide reductase that are translocated to the cytoplasmic membrane; twin-argninine leader-binding protein DmsD 1904632 4849012 APL_1677 Actinobacillus pleuropneumoniae serovar 5b str. L20 twin-argninine leader-binding protein DmsD YP_001054366.1 1904027 D 416269 CDS YP_001054367.1 126209142 4849805 1904636..1905145 1 NC_009053.1 ferredoxin 1905145 4849805 APL_1678 Actinobacillus pleuropneumoniae serovar 5b str. L20 ferredoxin YP_001054367.1 1904636 D 416269 CDS YP_001054368.1 126209143 4848850 complement(1905189..1905518) 1 NC_009053.1 transcriptional regulator 1905518 4848850 APL_1679 Actinobacillus pleuropneumoniae serovar 5b str. L20 transcriptional regulator YP_001054368.1 1905189 R 416269 CDS YP_001054369.1 126209144 4849080 complement(1905515..1906846) 1 NC_009053.1 hypothetical protein 1906846 4849080 APL_1680 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054369.1 1905515 R 416269 CDS YP_001054370.1 126209145 4850054 complement(1907178..1908869) 1 NC_009053.1 hypothetical protein 1908869 4850054 APL_1681 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054370.1 1907178 R 416269 CDS YP_001054371.1 126209146 4848986 complement(1908937..1912833) 1 NC_009053.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis; phosphoribosylformylglycinamidine synthase 1912833 purL 4848986 purL Actinobacillus pleuropneumoniae serovar 5b str. L20 phosphoribosylformylglycinamidine synthase YP_001054371.1 1908937 R 416269 CDS YP_001054372.1 126209147 4848567 1913060..1913806 1 NC_009053.1 L-fucose operon activator 1913806 fucR 4848567 fucR Actinobacillus pleuropneumoniae serovar 5b str. L20 L-fucose operon activator YP_001054372.1 1913060 D 416269 CDS YP_001054373.1 126209148 4849689 1914009..1915775 1 NC_009053.1 catalyzes the conversion of the aldose L-fucose into the corresponding ketose L-fuculose; L-fucose isomerase 1915775 fucI 4849689 fucI Actinobacillus pleuropneumoniae serovar 5b str. L20 L-fucose isomerase YP_001054373.1 1914009 D 416269 CDS YP_001054374.1 126209149 4849690 1915853..1917286 1 NC_009053.1 L-fuculokinase 1917286 fucK 4849690 fucK Actinobacillus pleuropneumoniae serovar 5b str. L20 L-fuculokinase YP_001054374.1 1915853 D 416269 CDS YP_001054375.1 126209150 4849287 1917421..1917855 1 NC_009053.1 fucose operon FucU protein 1917855 fucU 4849287 fucU Actinobacillus pleuropneumoniae serovar 5b str. L20 fucose operon FucU protein YP_001054375.1 1917421 D 416269 CDS YP_001054376.1 126209151 4850363 1917906..1918556 1 NC_009053.1 catalyzes the formation of glycerone phosphate and (S)-lactaldehyde from L-fuculose 1-phosphate; L-fuculose phosphate aldolase 1918556 fucA 4850363 fucA Actinobacillus pleuropneumoniae serovar 5b str. L20 L-fuculose phosphate aldolase YP_001054376.1 1917906 D 416269 CDS YP_001054377.1 126209152 4850213 1918611..1919900 1 NC_009053.1 L-fucose permease 1919900 fucP 4850213 fucP Actinobacillus pleuropneumoniae serovar 5b str. L20 L-fucose permease YP_001054377.1 1918611 D 416269 CDS YP_001054378.1 126209153 4848950 1920020..1921171 1 NC_009053.1 L-1,2-propanediol oxidoreductase 1921171 4848950 APL_1689 Actinobacillus pleuropneumoniae serovar 5b str. L20 L-1,2-propanediol oxidoreductase YP_001054378.1 1920020 D 416269 CDS YP_001054379.1 126209154 4849681 1921375..1922016 1 NC_009053.1 inner membrane protein 1922016 4849681 APL_1690 Actinobacillus pleuropneumoniae serovar 5b str. L20 inner membrane protein YP_001054379.1 1921375 D 416269 CDS YP_001054380.1 126209155 4849108 1922228..1922887 1 NC_009053.1 ABC transporter, permease protein, amino acid 1922887 4849108 APL_1691 Actinobacillus pleuropneumoniae serovar 5b str. L20 ABC transporter, permease protein, amino acid YP_001054380.1 1922228 D 416269 CDS YP_001054381.1 126209156 4850063 1922877..1923545 1 NC_009053.1 ABC transporter, permease protein, amino acid 1923545 4850063 APL_1692 Actinobacillus pleuropneumoniae serovar 5b str. L20 ABC transporter, permease protein, amino acid YP_001054381.1 1922877 D 416269 CDS YP_001054382.1 126209157 4850064 1923546..1924277 1 NC_009053.1 amino acid ABC transporter ATP-binding protein 1924277 4850064 APL_1693 Actinobacillus pleuropneumoniae serovar 5b str. L20 amino acid ABC transporter ATP-binding protein YP_001054382.1 1923546 D 416269 CDS YP_001054383.1 126209158 4850202 1924338..1925174 1 NC_009053.1 pubmed:10459579; antigenic protein, ABC transporter-like protein 1925174 4850202 APL_1694 Actinobacillus pleuropneumoniae serovar 5b str. L20 antigenic protein, ABC transporter-like protein YP_001054383.1 1924338 D 416269 CDS YP_001054384.1 126209159 4849698 1925307..1927376 1 NC_009053.1 capsule polysaccharide modification protein LipA 1927376 kpsC 4849698 kpsC Actinobacillus pleuropneumoniae serovar 5b str. L20 capsule polysaccharide modification protein LipA YP_001054384.1 1925307 D 416269 CDS YP_001054385.1 126209160 4848561 1927399..1928715 1 NC_009053.1 capsule polysaccharide modification protein HcsB 1928715 hcsB 4848561 hcsB Actinobacillus pleuropneumoniae serovar 5b str. L20 capsule polysaccharide modification protein HcsB YP_001054385.1 1927399 D 416269 CDS YP_001054386.1 126209161 4849958 complement(1928704..1929798) 1 NC_009053.1 hypothetical protein 1929798 4849958 APL_1697 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054386.1 1928704 R 416269 CDS YP_001054387.1 126209162 4849252 complement(1929811..1930491) 1 NC_009053.1 catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate in anaerobic L-ascorbate utilization; 3-keto-L-gulonate-6-phosphate decarboxylase 1930491 ulaD 4849252 ulaD Actinobacillus pleuropneumoniae serovar 5b str. L20 3-keto-L-gulonate-6-phosphate decarboxylase YP_001054387.1 1929811 R 416269 CDS YP_001054388.1 126209163 4849334 complement(1930564..1931031) 1 NC_009053.1 ascorbate-specific phosphotransferase protein IIA component 1931031 ulaC 4849334 ulaC Actinobacillus pleuropneumoniae serovar 5b str. L20 ascorbate-specific phosphotransferase protein IIA component YP_001054388.1 1930564 R 416269 CDS YP_001054389.2 162329624 4849168 complement(1931109..1932914) 1 NC_009053.1 PTS system ascorbate-specific transporter subunits IICB 1932914 ulaA 4849168 ulaA Actinobacillus pleuropneumoniae serovar 5b str. L20 PTS system ascorbate-specific transporter subunits IICB YP_001054389.2 1931109 R 416269 CDS YP_001054390.1 126209165 4849169 1933388..1934479 1 NC_009053.1 L-ascorbate 6-phosphate lactonase 1934479 ulaG 4849169 ulaG Actinobacillus pleuropneumoniae serovar 5b str. L20 L-ascorbate 6-phosphate lactonase YP_001054390.1 1933388 D 416269 CDS YP_001054391.1 126209166 4848517 1934581..1935327 1 NC_009053.1 negative regulator of ulaG and ulaABCDEF; transcriptional repressor UlaR 1935327 ulaR 4848517 ulaR Actinobacillus pleuropneumoniae serovar 5b str. L20 transcriptional repressor UlaR YP_001054391.1 1934581 D 416269 CDS YP_001054392.1 126209167 4849328 1935413..1936273 1 NC_009053.1 L-xylulose 5-phosphate 3-epimerase activity not yet demonstrated; may be involved in the utilization of 2,3-diketo-L-gulonate; L-xylulose 5-phosphate 3-epimerase 1936273 4849328 APL_1703 Actinobacillus pleuropneumoniae serovar 5b str. L20 L-xylulose 5-phosphate 3-epimerase YP_001054392.1 1935413 D 416269 CDS YP_001054393.1 126209168 4850342 1936300..1936980 1 NC_009053.1 catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source; L-ribulose-5-phosphate 4-epimerase 1936980 araD 4850342 araD Actinobacillus pleuropneumoniae serovar 5b str. L20 L-ribulose-5-phosphate 4-epimerase YP_001054393.1 1936300 D 416269 CDS YP_001054394.1 126209169 4850071 complement(1937132..1937761) 1 NC_009053.1 FKBP-type peptidyl-prolyl cis-trans isomerase 1937761 4850071 APL_1705 Actinobacillus pleuropneumoniae serovar 5b str. L20 FKBP-type peptidyl-prolyl cis-trans isomerase YP_001054394.1 1937132 R 416269 CDS YP_001054395.1 126209170 4848524 1938143..1938826 1 NC_009053.1 hypothetical protein 1938826 4848524 APL_1706 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054395.1 1938143 D 416269 CDS YP_001054396.1 126209171 4848903 1939172..1939606 1 NC_009053.1 hypothetical protein 1939606 4848903 APL_1707 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054396.1 1939172 D 416269 CDS YP_001054397.1 126209172 4848955 1939752..1940381 1 NC_009053.1 hypothetical protein 1940381 4848955 APL_1708 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054397.1 1939752 D 416269 CDS YP_001054398.1 126209173 4848956 1940493..1941149 1 NC_009053.1 hypothetical protein 1941149 4848956 APL_1709 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054398.1 1940493 D 416269 CDS YP_001054399.1 126209174 4849464 complement(1941209..1942135) 1 NC_009053.1 catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose; ADP-L-glycero-D-manno-heptose-6-epimerase 1942135 rfaD 4849464 rfaD Actinobacillus pleuropneumoniae serovar 5b str. L20 ADP-L-glycero-D-manno-heptose-6-epimerase YP_001054399.1 1941209 R 416269 CDS YP_001054400.1 126209175 4849403 complement(1942275..1942739) 1 NC_009053.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase 1942739 def 4849403 def Actinobacillus pleuropneumoniae serovar 5b str. L20 peptide deformylase YP_001054400.1 1942275 R 416269 CDS YP_001054401.1 126209176 4849130 1942973..1944127 1 NC_009053.1 DNA-processing protein subunit A 1944127 smf 4849130 smf Actinobacillus pleuropneumoniae serovar 5b str. L20 DNA-processing protein subunit A YP_001054401.1 1942973 D 416269 CDS YP_001054402.1 126209177 4849000 complement(1944171..1946177) 1 NC_009053.1 hypothetical protein 1946177 4849000 APL_1713 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054402.1 1944171 R 416269 CDS YP_001054403.1 126209178 4848704 complement(1946399..1947754) 1 NC_009053.1 membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr; PTS system ascorbate-specific transporter subunit IIC 1947754 ulaA 4848704 ulaA Actinobacillus pleuropneumoniae serovar 5b str. L20 PTS system ascorbate-specific transporter subunit IIC YP_001054403.1 1946399 R 416269 CDS YP_001054404.1 126209179 4849932 complement(1947763..1948035) 1 NC_009053.1 PTS system galactitol-specific transporter subunit IIB 1948035 sgaB 4849932 sgaB Actinobacillus pleuropneumoniae serovar 5b str. L20 PTS system galactitol-specific transporter subunit IIB YP_001054404.1 1947763 R 416269 CDS YP_001054405.1 126209180 4850557 1948338..1948751 1 NC_009053.1 forms a complex with SecY and SecG; SecYEG forms a putative protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force; preprotein translocase subunit SecE 1948751 secE 4850557 secE Actinobacillus pleuropneumoniae serovar 5b str. L20 preprotein translocase subunit SecE YP_001054405.1 1948338 D 416269 CDS YP_001054406.1 126209181 4850558 1948786..1949316 1 NC_009053.1 Modulates Rho-dependent transcription termination; transcription antitermination protein NusG 1949316 nusG 4850558 nusG Actinobacillus pleuropneumoniae serovar 5b str. L20 transcription antitermination protein NusG YP_001054406.1 1948786 D 416269 CDS YP_001054407.1 126209182 4848949 1949605..1950033 1 NC_009053.1 binds directly to 23S ribosomal RNA; 50S ribosomal protein L11 1950033 rplK 4848949 rplK Actinobacillus pleuropneumoniae serovar 5b str. L20 50S ribosomal protein L11 YP_001054407.1 1949605 D 416269 CDS YP_001054408.1 126209183 4849494 1950038..1950727 1 NC_009053.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA; 50S ribosomal protein L1 1950727 rplA 4849494 rplA Actinobacillus pleuropneumoniae serovar 5b str. L20 50S ribosomal protein L1 YP_001054408.1 1950038 D 416269 CDS YP_001054409.1 126209184 4849068 1951016..1951507 1 NC_009053.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit; 50S ribosomal protein L10 1951507 rplJ 4849068 rplJ Actinobacillus pleuropneumoniae serovar 5b str. L20 50S ribosomal protein L10 YP_001054409.1 1951016 D 416269 CDS YP_001054410.1 126209185 4849283 1951568..1951936 1 NC_009053.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors; 50S ribosomal protein L7/L12 1951936 rplL 4849283 rplL Actinobacillus pleuropneumoniae serovar 5b str. L20 50S ribosomal protein L7/L12 YP_001054410.1 1951568 D 416269 CDS YP_001054411.1 126209186 4849261 1952100..1952372 1 NC_009053.1 hypothetical protein 1952372 4849261 APL_1722 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054411.1 1952100 D 416269 CDS YP_001054412.1 126209187 4848987 1952377..1953633 1 NC_009053.1 hypothetical protein 1953633 4848987 APL_1723 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054412.1 1952377 D 416269 CDS YP_001054413.1 126209188 4848895 1954021..1954560 1 NC_009053.1 hypothetical protein 1954560 4848895 APL_1724 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054413.1 1954021 D 416269 CDS YP_001054414.1 126209189 4848896 1955367..1956155 1 NC_009053.1 hypothetical protein 1956155 4848896 APL_1725 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054414.1 1955367 D 416269 CDS YP_001054415.1 126209190 4848832 1956260..1956808 1 NC_009053.1 hypothetical protein 1956808 4848832 APL_1726 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054415.1 1956260 D 416269 CDS YP_001054416.1 126209191 4848804 1957228..1961256 1 NC_009053.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme; DNA-directed RNA polymerase subunit beta 1961256 rpoB 4848804 rpoB Actinobacillus pleuropneumoniae serovar 5b str. L20 DNA-directed RNA polymerase subunit beta YP_001054416.1 1957228 D 416269 CDS YP_001054417.1 126209192 4850553 1961382..1965620 1 NC_009053.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter; DNA-directed RNA polymerase subunit beta' 1965620 rpoC 4850553 rpoC Actinobacillus pleuropneumoniae serovar 5b str. L20 DNA-directed RNA polymerase subunit beta' YP_001054417.1 1961382 D 416269 CDS YP_001054418.1 126209193 4849159 1965725..1967146 1 NC_009053.1 hypothetical protein 1967146 4849159 APL_1729 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054418.1 1965725 D 416269 CDS YP_001054419.1 126209194 4850444 1967877..1968107 1 NC_009053.1 hypothetical protein 1968107 4850444 APL_1730 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054419.1 1967877 D 416269 CDS YP_001054420.1 126209195 4849848 1968119..1968505 1 NC_009053.1 hypothetical protein 1968505 4849848 APL_1731 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054420.1 1968119 D 416269 CDS YP_001054421.1 126209196 4848982 complement(1968640..1969056) 1 NC_009053.1 hypothetical protein 1969056 4848982 APL_1732 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054421.1 1968640 R 416269 CDS YP_001054422.1 126209197 4848983 1969302..1969952 1 NC_009053.1 hypothetical protein 1969952 4848983 APL_1733 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054422.1 1969302 D 416269 CDS YP_001054423.1 126209198 4849587 complement(1970132..1970911) 1 NC_009053.1 hypothetical protein 1970911 4849587 APL_1734 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054423.1 1970132 R 416269 CDS YP_001054424.1 126209199 4849314 complement(1970984..1972306) 1 NC_009053.1 heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease ATP-binding subunit HslU 1972306 hslU 4849314 hslU Actinobacillus pleuropneumoniae serovar 5b str. L20 ATP-dependent protease ATP-binding subunit HslU YP_001054424.1 1970984 R 416269 CDS YP_001054425.1 126209200 4849526 complement(1972361..1972882) 1 NC_009053.1 heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease peptidase subunit 1972882 hslV 4849526 hslV Actinobacillus pleuropneumoniae serovar 5b str. L20 ATP-dependent protease peptidase subunit YP_001054425.1 1972361 R 416269 CDS YP_001054426.1 126209201 4848991 complement(1972961..1973674) 1 NC_009053.1 Regulatory factor involved in maltose metabolism; sugar fermentation stimulation protein A 1973674 sfsA 4848991 sfsA Actinobacillus pleuropneumoniae serovar 5b str. L20 sugar fermentation stimulation protein A YP_001054426.1 1972961 R 416269 CDS YP_001054427.1 126209202 4849987 complement(1973932..1974324) 1 NC_009053.1 lactoylglutathione lyase 1974324 4849987 APL_1738 Actinobacillus pleuropneumoniae serovar 5b str. L20 lactoylglutathione lyase YP_001054427.1 1973932 R 416269 CDS YP_001054428.1 126209203 4848691 1974422..1975567 1 NC_009053.1 A/G-specific adenine glycosylase 1975567 mutY 4848691 mutY Actinobacillus pleuropneumoniae serovar 5b str. L20 A/G-specific adenine glycosylase YP_001054428.1 1974422 D 416269 CDS YP_001054429.1 126209204 4848882 1975571..1975846 1 NC_009053.1 hypothetical protein 1975846 4848882 APL_1740 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054429.1 1975571 D 416269 CDS YP_001054430.1 126209205 4848883 1975864..1976961 1 NC_009053.1 Murein hydrolase C; membrane-bound; lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; murein transglycosylase C 1976961 mltC 4848883 mltC Actinobacillus pleuropneumoniae serovar 5b str. L20 murein transglycosylase C YP_001054430.1 1975864 D 416269 CDS YP_001054431.1 126209206 4848475 1977954..1979345 1 NC_009053.1 signal recognition particle protein (sigma-54 like protein) 1979345 srp54 4848475 srp54 Actinobacillus pleuropneumoniae serovar 5b str. L20 signal recognition particle protein (sigma-54 like protein) YP_001054431.1 1977954 D 416269 CDS YP_001054432.1 126209207 4848643 complement(1979499..1981163) 1 NC_009053.1 Ser/Thr protein phosphatase family protein 1981163 4848643 APL_1743 Actinobacillus pleuropneumoniae serovar 5b str. L20 Ser/Thr protein phosphatase family protein YP_001054432.1 1979499 R 416269 CDS YP_001054433.1 126209208 4848618 complement(1981355..1982521) 1 NC_009053.1 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase 1982521 ubiF 4848618 ubiF Actinobacillus pleuropneumoniae serovar 5b str. L20 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase YP_001054433.1 1981355 R 416269 CDS YP_001054434.1 126209209 4848619 complement(1982555..1982863) 1 NC_009053.1 hypothetical protein 1982863 4848619 APL_1745 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054434.1 1982555 R 416269 CDS YP_001054435.1 126209210 4849401 complement(1982836..1983150) 1 NC_009053.1 hypothetical protein 1983150 4849401 APL_1746 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054435.1 1982836 R 416269 CDS YP_001054436.1 126209211 4848710 1983337..1984863 1 NC_009053.1 competence protein comM 1984863 comM 4848710 comM Actinobacillus pleuropneumoniae serovar 5b str. L20 competence protein comM YP_001054436.1 1983337 D 416269 CDS YP_001054437.1 126209212 4849489 1984988..1986091 1 NC_009053.1 Outer membrane lipoprotein A precursor 1986091 4849489 APL_1748 Actinobacillus pleuropneumoniae serovar 5b str. L20 Outer membrane lipoprotein A precursor YP_001054437.1 1984988 D 416269 CDS YP_001054438.1 126209213 4849121 complement(1986137..1986901) 1 NC_009053.1 catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA; acyl-CoA thioester hydrolase YfbB 1986901 4849121 APL_1749 Actinobacillus pleuropneumoniae serovar 5b str. L20 acyl-CoA thioester hydrolase YfbB YP_001054438.1 1986137 R 416269 CDS YP_001054439.1 126209214 4849122 complement(1986901..1988607) 1 NC_009053.1 SEPHCHC synthase; forms 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1- carboxylate from 2-oxoglutarate and isochorismate in menaquinone biosynthesis; 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase 1988607 menD 4849122 menD Actinobacillus pleuropneumoniae serovar 5b str. L20 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase YP_001054439.1 1986901 R 416269 CDS YP_001054440.1 126209215 4848570 1988860..1989453 1 NC_009053.1 hypothetical protein 1989453 4848570 APL_1751 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054440.1 1988860 D 416269 CDS YP_001054441.1 126209216 4849607 1989491..1990180 1 NC_009053.1 Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate; N-acetylmannosamine-6-phosphate 2-epimerase 1990180 nanE 4849607 nanE Actinobacillus pleuropneumoniae serovar 5b str. L20 N-acetylmannosamine-6-phosphate 2-epimerase YP_001054441.1 1989491 D 416269 CDS YP_001054442.1 126209217 4849440 1990190..1991062 1 NC_009053.1 catalyzes the phosphorylation of the N-acetylmannosamine (ManNAc) liberated from N-acetyl-neuraminic acid by the nanA protein; N-acetylmannosamine kinase 1991062 nanK 4849440 nanK Actinobacillus pleuropneumoniae serovar 5b str. L20 N-acetylmannosamine kinase YP_001054442.1 1990190 D 416269 CDS YP_001054443.1 126209218 4848657 1991083..1991961 1 NC_009053.1 catalyzes the formation of pyruvate and N-acetylmannosamine from N-acetylneuraminic acid; N-acetylneuraminate lyase 1991961 nanA 4848657 nanA Actinobacillus pleuropneumoniae serovar 5b str. L20 N-acetylneuraminate lyase YP_001054443.1 1991083 D 416269 CDS YP_001054444.1 126209219 4848658 1992011..1992814 1 NC_009053.1 catalyzes the reversible formation of fructose 6-phosphate from glucosamine 6-phosphate; glucosamine-6-phosphate deaminase 1992814 nagB 4848658 nagB Actinobacillus pleuropneumoniae serovar 5b str. L20 glucosamine-6-phosphate deaminase YP_001054444.1 1992011 D 416269 CDS YP_001054445.1 126209220 4848984 1992866..1994011 1 NC_009053.1 catalyzes the formation of glucosamine 6-phosphate from N-acetylglucosamine 6-phosphate; N-acetylglucosamine-6-phosphate deacetylase 1994011 nagA 4848984 nagA Actinobacillus pleuropneumoniae serovar 5b str. L20 N-acetylglucosamine-6-phosphate deacetylase YP_001054445.1 1992866 D 416269 CDS YP_001054446.1 126209221 4849162 complement(1994160..1995554) 1 NC_009053.1 class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle; fumarate hydratase 1995554 fumC 4849162 fumC Actinobacillus pleuropneumoniae serovar 5b str. L20 fumarate hydratase YP_001054446.1 1994160 R 416269 CDS YP_001054447.1 126209222 4850142 complement(1995709..1996365) 1 NC_009053.1 DNA transformation protein 1996365 4850142 APL_1758 Actinobacillus pleuropneumoniae serovar 5b str. L20 DNA transformation protein YP_001054447.1 1995709 R 416269 CDS YP_001054448.1 126209223 4849705 1996773..1997084 1 NC_009053.1 30S ribosomal protein S10 1997084 rpsJ 4849705 rpsJ Actinobacillus pleuropneumoniae serovar 5b str. L20 30S ribosomal protein S10 YP_001054448.1 1996773 D 416269 CDS YP_001054449.1 126209224 4849706 1997110..1997736 1 NC_009053.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin; 50S ribosomal protein L3 1997736 rplC 4849706 rplC Actinobacillus pleuropneumoniae serovar 5b str. L20 50S ribosomal protein L3 YP_001054449.1 1997110 D 416269 CDS YP_001054450.1 126209225 4849201 1997752..1998354 1 NC_009053.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA; 50S ribosomal protein L4 1998354 rplD 4849201 rplD Actinobacillus pleuropneumoniae serovar 5b str. L20 50S ribosomal protein L4 YP_001054450.1 1997752 D 416269 CDS YP_001054451.1 126209226 4849806 1998351..1998656 1 NC_009053.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel; 50S ribosomal protein L23 1998656 rplW 4849806 rplW Actinobacillus pleuropneumoniae serovar 5b str. L20 50S ribosomal protein L23 YP_001054451.1 1998351 D 416269 CDS YP_001054452.1 126209227 4849586 1998677..1999498 1 NC_009053.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation; 50S ribosomal protein L2 1999498 rplB 4849586 rplB Actinobacillus pleuropneumoniae serovar 5b str. L20 50S ribosomal protein L2 YP_001054452.1 1998677 D 416269 CDS YP_001054453.1 126209228 4849009 1999526..1999801 1 NC_009053.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA; 30S ribosomal protein S19 1999801 rpsS 4849009 rpsS Actinobacillus pleuropneumoniae serovar 5b str. L20 30S ribosomal protein S19 YP_001054453.1 1999526 D 416269 CDS YP_001054454.1 126209229 4849010 1999812..2000144 1 NC_009053.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center; 50S ribosomal protein L22 2000144 rplV 4849010 rplV Actinobacillus pleuropneumoniae serovar 5b str. L20 50S ribosomal protein L22 YP_001054454.1 1999812 D 416269 CDS YP_001054455.1 126209230 4848566 2000163..2000870 1 NC_009053.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation; 30S ribosomal protein S3 2000870 rpsC 4848566 rpsC Actinobacillus pleuropneumoniae serovar 5b str. L20 30S ribosomal protein S3 YP_001054455.1 2000163 D 416269 CDS YP_001054456.1 126209231 4850219 2000884..2001294 1 NC_009053.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e; 50S ribosomal protein L16 2001294 rplP 4850219 rplP Actinobacillus pleuropneumoniae serovar 5b str. L20 50S ribosomal protein L16 YP_001054456.1 2000884 D 416269 CDS YP_001054457.1 126209232 4849389 2001294..2001485 1 NC_009053.1 one of the stabilizing components for the large ribosomal subunit; 50S ribosomal protein L29 2001485 rpmC 4849389 rpmC Actinobacillus pleuropneumoniae serovar 5b str. L20 50S ribosomal protein L29 YP_001054457.1 2001294 D 416269 CDS YP_001054458.1 126209233 4849678 2001485..2001739 1 NC_009053.1 primary binding protein; helps mediate assembly; involved in translation fidelity; 30S ribosomal protein S17 2001739 rpsQ 4849678 rpsQ Actinobacillus pleuropneumoniae serovar 5b str. L20 30S ribosomal protein S17 YP_001054458.1 2001485 D 416269 CDS YP_004770516.1 342515706 11031964 2001979..2002350 1 NC_009053.1 50S ribosomal protein L14 2002350 11031964 APL_1769a Actinobacillus pleuropneumoniae serovar 5b str. L20 50S ribosomal protein L14 YP_004770516.1 2001979 D 416269 CDS YP_001054459.1 126209234 4849679 2002361..2002672 1 NC_009053.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel; 50S ribosomal protein L24 2002672 rplX 4849679 rplX Actinobacillus pleuropneumoniae serovar 5b str. L20 50S ribosomal protein L24 YP_001054459.1 2002361 D 416269 CDS YP_001054460.1 126209235 4850224 2002690..2003229 1 NC_009053.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13; 50S ribosomal protein L5 2003229 rplE 4850224 rplE Actinobacillus pleuropneumoniae serovar 5b str. L20 50S ribosomal protein L5 YP_001054460.1 2002690 D 416269 CDS YP_001054461.1 126209236 4849185 2003241..2003546 1 NC_009053.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif; 30S ribosomal protein S14 2003546 rpsN 4849185 rpsN Actinobacillus pleuropneumoniae serovar 5b str. L20 30S ribosomal protein S14 YP_001054461.1 2003241 D 416269 CDS YP_001054462.1 126209237 4849183 2003583..2003975 1 NC_009053.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; 30S ribosomal protein S8 2003975 rpsH 4849183 rpsH Actinobacillus pleuropneumoniae serovar 5b str. L20 30S ribosomal protein S8 YP_001054462.1 2003583 D 416269 CDS YP_001054463.1 126209238 4850353 2003992..2004525 1 NC_009053.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance; 50S ribosomal protein L6 2004525 rplF 4850353 rplF Actinobacillus pleuropneumoniae serovar 5b str. L20 50S ribosomal protein L6 YP_001054463.1 2003992 D 416269 CDS YP_001054464.1 126209239 4850354 2004540..2004893 1 NC_009053.1 binds 5S rRNA along with protein L5 and L25; 50S ribosomal protein L18 2004893 rplR 4850354 rplR Actinobacillus pleuropneumoniae serovar 5b str. L20 50S ribosomal protein L18 YP_001054464.1 2004540 D 416269 CDS YP_001054465.1 126209240 4849674 2004908..2005408 1 NC_009053.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance; 30S ribosomal protein S5 2005408 rpsE 4849674 rpsE Actinobacillus pleuropneumoniae serovar 5b str. L20 30S ribosomal protein S5 YP_001054465.1 2004908 D 416269 CDS YP_001054466.1 126209241 4849961 2005415..2005594 1 NC_009053.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7; 50S ribosomal protein L30 2005594 rpmD 4849961 rpmD Actinobacillus pleuropneumoniae serovar 5b str. L20 50S ribosomal protein L30 YP_001054466.1 2005415 D 416269 CDS YP_001054467.1 126209242 4848606 2005599..2006033 1 NC_009053.1 late assembly protein; 50S ribosomal protein L15 2006033 rplO 4848606 rplO Actinobacillus pleuropneumoniae serovar 5b str. L20 50S ribosomal protein L15 YP_001054467.1 2005599 D 416269 CDS YP_001054468.1 126209243 4848922 2006037..2007359 1 NC_009053.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY 2007359 secY 4848922 secY Actinobacillus pleuropneumoniae serovar 5b str. L20 preprotein translocase subunit SecY YP_001054468.1 2006037 D 416269 CDS YP_001054469.1 126209244 4848923 2007385..2007498 1 NC_009053.1 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif; 50S ribosomal protein L36 2007498 rpmJ 4848923 rpmJ Actinobacillus pleuropneumoniae serovar 5b str. L20 50S ribosomal protein L36 YP_001054469.1 2007385 D 416269 CDS YP_001054470.1 126209245 4849271 2007635..2007991 1 NC_009053.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA; 30S ribosomal protein S13 2007991 rpsM 4849271 rpsM Actinobacillus pleuropneumoniae serovar 5b str. L20 30S ribosomal protein S13 YP_001054470.1 2007635 D 416269 CDS YP_001054471.1 126209246 4848916 2008008..2008397 1 NC_009053.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3; 30S ribosomal protein S11 2008397 rpsK 4848916 rpsK Actinobacillus pleuropneumoniae serovar 5b str. L20 30S ribosomal protein S11 YP_001054471.1 2008008 D 416269 CDS YP_001054472.1 126209247 4848996 2008426..2009052 1 NC_009053.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination; 30S ribosomal protein S4 2009052 rpsD 4848996 rpsD Actinobacillus pleuropneumoniae serovar 5b str. L20 30S ribosomal protein S4 YP_001054472.1 2008426 D 416269 CDS YP_001054473.1 126209248 4849580 2009118..2010107 1 NC_009053.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha 2010107 rpoA 4849580 rpoA Actinobacillus pleuropneumoniae serovar 5b str. L20 DNA-directed RNA polymerase subunit alpha YP_001054473.1 2009118 D 416269 CDS YP_001054474.1 126209249 4849581 2010213..2010527 1 NC_009053.1 50S ribosomal protein L17 2010527 rplQ 4849581 rplQ Actinobacillus pleuropneumoniae serovar 5b str. L20 50S ribosomal protein L17 YP_001054474.1 2010213 D 416269 CDS YP_001054475.1 126209250 4848767 2010764..2011012 1 NC_009053.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity; 30S ribosomal protein S16 2011012 rpsP 4848767 rpsP Actinobacillus pleuropneumoniae serovar 5b str. L20 30S ribosomal protein S16 YP_001054475.1 2010764 D 416269 CDS YP_001054476.1 126209251 4849140 2011046..2011573 1 NC_009053.1 Essential for efficient processing of 16S rRNA; 16S rRNA-processing protein RimM 2011573 rimM 4849140 rimM Actinobacillus pleuropneumoniae serovar 5b str. L20 16S rRNA-processing protein RimM YP_001054476.1 2011046 D 416269 CDS YP_001054477.1 126209252 4848951 2011631..2012386 1 NC_009053.1 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA; tRNA (guanine-N(1)-)-methyltransferase 2012386 trmD 4848951 trmD Actinobacillus pleuropneumoniae serovar 5b str. L20 tRNA (guanine-N(1)-)-methyltransferase YP_001054477.1 2011631 D 416269 CDS YP_001054478.1 126209253 4849390 2012412..2012762 1 NC_009053.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site; 50S ribosomal protein L19 2012762 rplS 4849390 rplS Actinobacillus pleuropneumoniae serovar 5b str. L20 50S ribosomal protein L19 YP_001054478.1 2012412 D 416269 CDS YP_001054479.1 126209254 4849391 complement(2012932..2014125) 1 NC_009053.1 hypothetical protein 2014125 4849391 APL_1790 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054479.1 2012932 R 416269 CDS YP_001054480.1 126209255 4849022 2014341..2015456 1 NC_009053.1 periplasmic iron/siderophore binding protein 2015456 4849022 APL_1791 Actinobacillus pleuropneumoniae serovar 5b str. L20 periplasmic iron/siderophore binding protein YP_001054480.1 2014341 D 416269 CDS YP_001054481.1 126209256 4850471 2015459..2016340 1 NC_009053.1 Fe(III) dicitrate ABC transporter permease 2016340 4850471 APL_1792 Actinobacillus pleuropneumoniae serovar 5b str. L20 Fe(III) dicitrate ABC transporter permease YP_001054481.1 2015459 D 416269 CDS YP_001054482.1 126209257 4849244 2016356..2017123 1 NC_009053.1 Fe(III) dicitrate ABC transporter, ATP-binding protein 2017123 4849244 APL_1793 Actinobacillus pleuropneumoniae serovar 5b str. L20 Fe(III) dicitrate ABC transporter, ATP-binding protein YP_001054482.1 2016356 D 416269 CDS YP_001054483.1 126209258 4849373 2017133..2017564 1 NC_009053.1 pseudoazurin 2017564 4849373 APL_1794 Actinobacillus pleuropneumoniae serovar 5b str. L20 pseudoazurin YP_001054483.1 2017133 D 416269 CDS YP_001054484.1 126209259 4849374 2017573..2018679 1 NC_009053.1 periplasmic iron/siderophore binding protein 2018679 4849374 APL_1795 Actinobacillus pleuropneumoniae serovar 5b str. L20 periplasmic iron/siderophore binding protein YP_001054484.1 2017573 D 416269 CDS YP_001054485.1 126209260 4849085 2018735..2019586 1 NC_009053.1 hypothetical protein 2019586 4849085 APL_1796 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054485.1 2018735 D 416269 CDS YP_001054486.1 126209261 4850316 complement(2019629..2020228) 1 NC_009053.1 TorD; involved in the biogenesis of torA; acts on torA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor; chaperone protein TorD 2020228 torD 4850316 torD Actinobacillus pleuropneumoniae serovar 5b str. L20 chaperone protein TorD YP_001054486.1 2019629 R 416269 CDS YP_001054487.1 126209262 4848614 complement(2020228..2022711) 1 NC_009053.1 trimethylamine-N-oxide reductase precursor 2022711 torA 4848614 torA Actinobacillus pleuropneumoniae serovar 5b str. L20 trimethylamine-N-oxide reductase precursor YP_001054487.1 2020228 R 416269 CDS YP_001054488.1 126209263 4849763 complement(2022721..2023341) 1 NC_009053.1 pentahemic c-type cytochrome 2023341 torC 4849763 torC Actinobacillus pleuropneumoniae serovar 5b str. L20 pentahemic c-type cytochrome YP_001054488.1 2022721 R 416269 CDS YP_001054489.1 126209264 4849764 2023532..2024437 1 NC_009053.1 glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit alpha 2024437 glyQ 4849764 glyQ Actinobacillus pleuropneumoniae serovar 5b str. L20 glycyl-tRNA synthetase subunit alpha YP_001054489.1 2023532 D 416269 CDS YP_001054490.1 126209265 4850144 2024484..2024867 1 NC_009053.1 hypothetical protein 2024867 4850144 APL_1801 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054490.1 2024484 D 416269 CDS YP_001054491.1 126209266 4850392 2025340..2025744 1 NC_009053.1 hypothetical protein 2025744 4850392 APL_1802 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054491.1 2025340 D 416269 CDS YP_001054492.1 126209267 4848617 2025782..2027851 1 NC_009053.1 glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit beta 2027851 glyS 4848617 glyS Actinobacillus pleuropneumoniae serovar 5b str. L20 glycyl-tRNA synthetase subunit beta YP_001054492.1 2025782 D 416269 CDS YP_001054493.1 126209268 4848622 2027967..2028257 1 NC_009053.1 hypothetical protein 2028257 4848622 APL_1804 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054493.1 2027967 D 416269 CDS YP_001054494.1 126209269 4848623 2028258..2029268 1 NC_009053.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerC 2029268 xerC 4848623 xerC Actinobacillus pleuropneumoniae serovar 5b str. L20 site-specific tyrosine recombinase XerC YP_001054494.1 2028258 D 416269 CDS YP_001054495.1 126209270 4849081 complement(2029272..2029661) 1 NC_009053.1 hypothetical protein 2029661 4849081 APL_1806 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054495.1 2029272 R 416269 CDS YP_001054496.1 126209271 4850020 complement(2029725..2030471) 1 NC_009053.1 hypothetical protein 2030471 4850020 APL_1807 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054496.1 2029725 R 416269 CDS YP_001054497.1 126209272 4848921 complement(2030513..2031244) 1 NC_009053.1 catalyzes the formation of 2,3=diacylglucosamine 1-phosphate from UDP-2,3=diacylglucosamine; UDP-2,3-diacylglucosamine hydrolase 2031244 lpxH 4848921 lpxH Actinobacillus pleuropneumoniae serovar 5b str. L20 UDP-2,3-diacylglucosamine hydrolase YP_001054497.1 2030513 R 416269 CDS YP_001054498.1 126209273 4848612 complement(2031277..2031801) 1 NC_009053.1 hypothetical protein 2031801 4848612 APL_1809 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054498.1 2031277 R 416269 CDS YP_001054499.1 126209274 4848613 complement(2031836..2032624) 1 NC_009053.1 Mg-dependent DNAse 2032624 4848613 APL_1810 Actinobacillus pleuropneumoniae serovar 5b str. L20 Mg-dependent DNAse YP_001054499.1 2031836 R 416269 CDS YP_001054500.1 126209275 4849623 2033633..2034265 1 NC_009053.1 hypothetical protein 2034265 4849623 APL_1811 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054500.1 2033633 D 416269 CDS YP_001054501.1 126209276 4848873 complement(2036534..2037310) 1 NC_009053.1 macrolide-specific efflux protein 2037310 macA 4848873 macA Actinobacillus pleuropneumoniae serovar 5b str. L20 macrolide-specific efflux protein YP_001054501.1 2036534 R 416269 CDS YP_001054502.1 126209277 4850564 complement(2037606..2038382) 1 NC_009053.1 hypothetical protein 2038382 4850564 APL_1815 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054502.1 2037606 R 416269 CDS YP_001054503.1 126209278 4848871 complement(2038713..2039696) 1 NC_009053.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA; DNA polymerase III subunit delta' 2039696 holB 4848871 holB Actinobacillus pleuropneumoniae serovar 5b str. L20 DNA polymerase III subunit delta' YP_001054503.1 2038713 R 416269 CDS YP_001054504.1 126209279 4850003 complement(2039699..2040325) 1 NC_009053.1 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP); thymidylate kinase 2040325 tmk 4850003 tmk Actinobacillus pleuropneumoniae serovar 5b str. L20 thymidylate kinase YP_001054504.1 2039699 R 416269 CDS YP_001054505.1 126209280 4850004 complement(2040329..2041363) 1 NC_009053.1 hypothetical protein 2041363 4850004 APL_1818 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054505.1 2040329 R 416269 CDS YP_001054506.1 126209281 4848526 complement(2041962..2042195) 1 NC_009053.1 carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein 2042195 acpP 4848526 acpP Actinobacillus pleuropneumoniae serovar 5b str. L20 acyl carrier protein YP_001054506.1 2041962 R 416269 CDS YP_001054507.1 126209282 4850554 complement(2042459..2043133) 1 NC_009053.1 ribulose-phosphate 3-epimerase 2043133 rpe 4850554 rpe Actinobacillus pleuropneumoniae serovar 5b str. L20 ribulose-phosphate 3-epimerase YP_001054507.1 2042459 R 416269 CDS YP_001054508.1 126209283 4848556 2043355..2043624 1 NC_009053.1 RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 2043624 rpmE2 4848556 rpmE2 Actinobacillus pleuropneumoniae serovar 5b str. L20 50S ribosomal protein L31 YP_001054508.1 2043355 D 416269 CDS YP_001054509.1 126209284 4848557 2043638..2043763 1 NC_009053.1 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group do not have the motif; 50S ribosomal protein L36 2043763 rpmJ 4848557 rpmJ Actinobacillus pleuropneumoniae serovar 5b str. L20 50S ribosomal protein L36 YP_001054509.1 2043638 D 416269 CDS YP_001054510.1 126209285 4849753 complement(2043868..2046270) 1 NC_009053.1 penicillin-binding protein 1B (PBP1b) 2046270 pbpB 4849753 pbpB Actinobacillus pleuropneumoniae serovar 5b str. L20 penicillin-binding protein 1B (PBP1b) YP_001054510.1 2043868 R 416269 CDS YP_001054511.1 126209286 4849102 complement(2046349..2047206) 1 NC_009053.1 catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA; naphthoate synthase 2047206 menB 4849102 menB Actinobacillus pleuropneumoniae serovar 5b str. L20 naphthoate synthase YP_001054511.1 2046349 R 416269 CDS YP_001054512.1 126209287 4850525 complement(2047341..2049047) 1 NC_009053.1 guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase (ppGpp)ase) 2049047 spoT 4850525 spoT Actinobacillus pleuropneumoniae serovar 5b str. L20 guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase (ppGpp)ase) YP_001054512.1 2047341 R 416269 CDS YP_001054513.1 126209288 4850526 complement(2049150..2049425) 1 NC_009053.1 promotes RNA polymerase assembly or stability; latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits; DNA-directed RNA polymerase subunit omega 2049425 rpoZ 4850526 rpoZ Actinobacillus pleuropneumoniae serovar 5b str. L20 DNA-directed RNA polymerase subunit omega YP_001054513.1 2049150 R 416269 CDS YP_001054514.1 126209289 4848872 complement(2049552..2051633) 1 NC_009053.1 catalyzes branch migration in Holliday junction intermediates; ATP-dependent DNA helicase RecG 2051633 recG 4848872 recG Actinobacillus pleuropneumoniae serovar 5b str. L20 ATP-dependent DNA helicase RecG YP_001054514.1 2049552 R 416269 CDS YP_001054515.1 126209290 4850238 complement(2051757..2052122) 1 NC_009053.1 PilT protein-like protein 2052122 4850238 APL_1828 Actinobacillus pleuropneumoniae serovar 5b str. L20 PilT protein-like protein YP_001054515.1 2051757 R 416269 CDS YP_001054516.1 126209291 4849525 complement(2052185..2052472) 1 NC_009053.1 hypothetical protein 2052472 4849525 APL_1829 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054516.1 2052185 R 416269 CDS YP_001054517.1 126209292 4849609 2052678..2054393 1 NC_009053.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro); prolyl-tRNA synthetase 2054393 syp 4849609 syp Actinobacillus pleuropneumoniae serovar 5b str. L20 prolyl-tRNA synthetase YP_001054517.1 2052678 D 416269 CDS YP_001054518.1 126209293 4849610 complement(2054650..2055231) 1 NC_009053.1 Bacteria have multiple sigma factors which are active under specific conditions; the sigma factor binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; RNA polymerase sigma factor 2055231 4849610 APL_1831 Actinobacillus pleuropneumoniae serovar 5b str. L20 RNA polymerase sigma factor YP_001054518.1 2054650 R 416269 CDS YP_001054519.1 126209294 4850019 2055320..2056276 1 NC_009053.1 in Escherichia coli this periplasmic enzyme was found to encode the periplasmic catalytic subunit of an oxidoreductase; sulfite oxidase activity not demonstrated; requires inner membrane anchor protein YedZ; sulfite oxidase subunit YedY 2056276 4850019 APL_1832 Actinobacillus pleuropneumoniae serovar 5b str. L20 sulfite oxidase subunit YedY YP_001054519.1 2055320 D 416269 CDS YP_001054520.1 126209295 4850245 2056276..2056869 1 NC_009053.1 in Escherichia coli this inner membrane protein was found to anchor the periplasmic catalytic oxidoreductase YedY; sulfite oxidase activity not demonstrated; contains heme; sulfite oxidase subunit YedZ 2056869 4850245 APL_1833 Actinobacillus pleuropneumoniae serovar 5b str. L20 sulfite oxidase subunit YedZ YP_001054520.1 2056276 D 416269 CDS YP_001054521.1 126209296 4849511 complement(2056980..2057930) 1 NC_009053.1 binds with the catalytic core of RNA polymerase to produce the holoenzyme; this sigma factor is responsible for the expression of heat shock promoters; RNA polymerase factor sigma-32 2057930 rpoH 4849511 rpoH Actinobacillus pleuropneumoniae serovar 5b str. L20 RNA polymerase factor sigma-32 YP_001054521.1 2056980 R 416269 CDS YP_001054522.1 126209297 4849789 complement(2058079..2059236) 1 NC_009053.1 glycerol-3-phosphate transporter 2059236 glpT 4849789 glpT Actinobacillus pleuropneumoniae serovar 5b str. L20 glycerol-3-phosphate transporter YP_001054522.1 2058079 R 416269 CDS YP_001054523.1 126209298 4849790 2059991..2060503 1 NC_009053.1 hypothetical protein 2060503 4849790 APL_1836 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054523.1 2059991 D 416269 CDS YP_001054524.1 126209299 4849781 complement(2061014..2062006) 1 NC_009053.1 catalyzes the formation of asparagine from aspartate and ammonia; asparagine synthetase AsnA 2062006 asnA 4849781 asnA Actinobacillus pleuropneumoniae serovar 5b str. L20 asparagine synthetase AsnA YP_001054524.1 2061014 R 416269 CDS YP_001054525.1 126209300 4849437 2062188..2062649 1 NC_009053.1 transcriptional repressor of asnA which codes for aspartate-ammonia ligase; DNA-binding transcriptional regulator AsnC 2062649 asnC 4849437 asnC Actinobacillus pleuropneumoniae serovar 5b str. L20 DNA-binding transcriptional regulator AsnC YP_001054525.1 2062188 D 416269 CDS YP_001054526.1 126209301 4848809 2062838..2063602 1 NC_009053.1 catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate; involved in the pyrimidine salvage pathway; uridine phosphorylase 2063602 udp 4848809 udp Actinobacillus pleuropneumoniae serovar 5b str. L20 uridine phosphorylase YP_001054526.1 2062838 D 416269 CDS YP_001054527.1 126209302 4848810 2063672..2064148 1 NC_009053.1 4-hydroxybenzoate synthetase 2064148 ubiC 4848810 ubiC Actinobacillus pleuropneumoniae serovar 5b str. L20 4-hydroxybenzoate synthetase YP_001054527.1 2063672 D 416269 CDS YP_001054528.1 126209303 4850271 2064220..2065017 1 NC_009053.1 converts L-glutamate to D-glutamate, a component of peptidoglycan; glutamate racemase 2065017 murI 4850271 murI Actinobacillus pleuropneumoniae serovar 5b str. L20 glutamate racemase YP_001054528.1 2064220 D 416269 CDS YP_001054529.1 126209304 4848697 complement(2071381..2073147) 1 NC_009053.1 hemoprotein; NADPH dependent; with the alpha subunit (a flavoprotein) catalyzes the reduction of sulfite to sulfide; sulfite reductase subunit beta 2073147 cysI 4848697 cysI Actinobacillus pleuropneumoniae serovar 5b str. L20 sulfite reductase subunit beta YP_001054529.1 2071381 R 416269 CDS YP_001054530.1 126209305 4849567 complement(2073175..2074986) 1 NC_009053.1 sulfite reductase [NADPH] flavoprotein alpha-component (SIR-FP) 2074986 cysJ 4849567 cysJ Actinobacillus pleuropneumoniae serovar 5b str. L20 sulfite reductase [NADPH] flavoprotein alpha-component (SIR-FP) YP_001054530.1 2073175 R 416269 CDS YP_001054531.1 126209306 4849912 complement(2075287..2076018) 1 NC_009053.1 sulfate adenylate transferase subunit 1 2076018 cysN 4849912 cysN Actinobacillus pleuropneumoniae serovar 5b str. L20 sulfate adenylate transferase subunit 1 YP_001054531.1 2075287 R 416269 CDS YP_001054532.1 126209307 4850426 2076271..2077065 1 NC_009053.1 sulfate-binding protein 2077065 sbp 4850426 sbp Actinobacillus pleuropneumoniae serovar 5b str. L20 sulfate-binding protein YP_001054532.1 2076271 D 416269 CDS YP_001054533.1 126209308 4849189 2077084..2077896 1 NC_009053.1 sulfate transport system permease protein cysT 2077896 cysT 4849189 cysT Actinobacillus pleuropneumoniae serovar 5b str. L20 sulfate transport system permease protein cysT YP_001054533.1 2077084 D 416269 CDS YP_001054534.1 126209309 4849190 2077909..2078721 1 NC_009053.1 sulfate transport system permease protein cysW 2078721 cysW 4849190 cysW Actinobacillus pleuropneumoniae serovar 5b str. L20 sulfate transport system permease protein cysW YP_001054534.1 2077909 D 416269 CDS YP_001054535.1 126209310 4850485 2078734..2079804 1 NC_009053.1 sulfate/thiosulfate import ATP-binding protein cysA 2079804 cysA 4850485 cysA Actinobacillus pleuropneumoniae serovar 5b str. L20 sulfate/thiosulfate import ATP-binding protein cysA YP_001054535.1 2078734 D 416269 CDS YP_001054536.1 126209311 4849717 complement(2079893..2081038) 1 NC_009053.1 flavin mononucleotide-dependent dehydrogenase; functions in aerobic respiration and also has a role in anaerobic nitrate respiration; L-lactate dehydrogenase 2081038 lldD 4849717 lldD Actinobacillus pleuropneumoniae serovar 5b str. L20 L-lactate dehydrogenase YP_001054536.1 2079893 R 416269 CDS YP_001054537.1 126209312 4848554 complement(2081220..2081984) 1 NC_009053.1 bifunctional biotin operon repressor/biotin synthetase BirA 2081984 birA 4848554 birA Actinobacillus pleuropneumoniae serovar 5b str. L20 bifunctional biotin operon repressor/biotin synthetase BirA YP_001054537.1 2081220 R 416269 CDS YP_001054538.1 126209313 4849933 complement(2081993..2083027) 1 NC_009053.1 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis; UDP-N-acetylenolpyruvoylglucosamine reductase 2083027 murB 4849933 murB Actinobacillus pleuropneumoniae serovar 5b str. L20 UDP-N-acetylenolpyruvoylglucosamine reductase YP_001054538.1 2081993 R 416269 CDS YP_001054539.1 126209314 4849934 complement(2083177..2084271) 1 NC_009053.1 Outer membrane protein P5 precursor (OMP P5) 2084271 ompA 4849934 ompA Actinobacillus pleuropneumoniae serovar 5b str. L20 Outer membrane protein P5 precursor (OMP P5) YP_001054539.1 2083177 R 416269 CDS YP_001054540.1 126209315 4849756 complement(2084660..2086141) 1 NC_009053.1 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis; ketol-acid reductoisomerase 2086141 ilvC 4849756 ilvC Actinobacillus pleuropneumoniae serovar 5b str. L20 ketol-acid reductoisomerase YP_001054540.1 2084660 R 416269 CDS YP_001054541.1 126209316 4849425 2086378..2087619 1 NC_009053.1 hypothetical protein 2087619 pqiA 4849425 pqiA Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054541.1 2086378 D 416269 CDS YP_001054542.1 126209317 4850504 2087796..2088896 1 NC_009053.1 hypothetical protein 2088896 4850504 APL_1855 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054542.1 2087796 D 416269 CDS YP_001054543.1 126209318 4850505 2088868..2089221 1 NC_009053.1 hypothetical protein 2089221 4850505 APL_1856 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054543.1 2088868 D 416269 CDS YP_001054544.1 126209319 4849980 2089218..2089532 1 NC_009053.1 Copper chaperone; MerP 2089532 merP 4849980 merP Actinobacillus pleuropneumoniae serovar 5b str. L20 MerP YP_001054544.1 2089218 D 416269 CDS YP_001054545.1 126209320 4848546 complement(2089760..2090005) 1 NC_009053.1 hypothetical protein 2090005 4848546 APL_1858 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054545.1 2089760 R 416269 CDS YP_001054546.1 126209321 4849263 complement(2090045..2090944) 1 NC_009053.1 NADH-dependent butanol dehydrogenase 1 2090944 4849263 APL_1859 Actinobacillus pleuropneumoniae serovar 5b str. L20 NADH-dependent butanol dehydrogenase 1 YP_001054546.1 2090045 R 416269 CDS YP_001054547.1 126209322 4848539 2091060..2091962 1 NC_009053.1 LysR protein 2091962 lysR 4848539 lysR Actinobacillus pleuropneumoniae serovar 5b str. L20 LysR protein YP_001054547.1 2091060 D 416269 CDS YP_001054548.1 126209323 4848540 2092166..2092990 1 NC_009053.1 catalyzes the formation of N-succinyl-2-amino-6-ketopimelate from succinyl-CoA and tetrahydrodipicolinate in the lysine biosynthetic pathway; 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase 2092990 dapD 4848540 dapD Actinobacillus pleuropneumoniae serovar 5b str. L20 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase YP_001054548.1 2092166 D 416269 CDS YP_001054549.1 126209324 4849643 2093055..2093519 1 NC_009053.1 catalyzes the formation of 3-dehydroshikimate from 3-dehydroquinate in chorismate biosynthesis; 3-dehydroquinate dehydratase 2093519 aroQ 4849643 aroQ Actinobacillus pleuropneumoniae serovar 5b str. L20 3-dehydroquinate dehydratase YP_001054549.1 2093055 D 416269 CDS YP_001054550.1 126209325 4850008 2093512..2094300 1 NC_009053.1 glycosyltransferase 2094300 4850008 APL_1863 Actinobacillus pleuropneumoniae serovar 5b str. L20 glycosyltransferase YP_001054550.1 2093512 D 416269 CDS YP_001054551.1 126209326 4848716 2094471..2095010 1 NC_009053.1 biotin carboxyl carrier protein of acetyl-CoA carboxylase (BCCP) 2095010 accB 4848716 accB Actinobacillus pleuropneumoniae serovar 5b str. L20 biotin carboxyl carrier protein of acetyl-CoA carboxylase (BCCP) YP_001054551.1 2094471 D 416269 CDS YP_001054552.1 126209327 4848717 2095087..2096430 1 NC_009053.1 an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxylase subunit 2096430 accC 4848717 accC Actinobacillus pleuropneumoniae serovar 5b str. L20 acetyl-CoA carboxylase biotin carboxylase subunit YP_001054552.1 2095087 D 416269 CDS YP_001054553.1 126209328 4848790 complement(2096473..2097564) 1 NC_009053.1 in Escherichia coli MobA links a guanosine 5'-phosphate to molydopterin to form molybdopterin guanine dinucleotide during molybdenum cofactor biosynthesis; MobB is not essential but has been found to interact with multiple proteins involved in the molybdopterin guanine dinucleotide cofactor biosynthesis pathway; bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobA/MobB 2097564 mobAB 4848790 mobAB Actinobacillus pleuropneumoniae serovar 5b str. L20 bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobA/MobB YP_001054553.1 2096473 R 416269 CDS YP_001054554.1 126209329 4848559 2097651..2097920 1 NC_009053.1 hypothetical protein 2097920 4848559 APL_1867 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054554.1 2097651 D 416269 CDS YP_001054555.1 126209330 4849992 2097964..2098602 1 NC_009053.1 Thiol:disulfide interchange protein dsbA precursor 2098602 dsbA 4849992 dsbA Actinobacillus pleuropneumoniae serovar 5b str. L20 Thiol:disulfide interchange protein dsbA precursor YP_001054555.1 2097964 D 416269 CDS YP_001054556.1 126209331 4849787 complement(2098821..2099300) 1 NC_009053.1 hypothetical protein 2099300 4849787 APL_1869 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054556.1 2098821 R 416269 CDS YP_001054557.1 126209332 4849788 complement(2099777..2100700) 1 NC_009053.1 hypothetical protein 2100700 4849788 APL_1870 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054557.1 2099777 R 416269 CDS YP_001054558.1 126209333 4848792 complement(2100812..2101567) 1 NC_009053.1 hypothetical protein 2101567 4848792 APL_1871 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054558.1 2100812 R 416269 CDS YP_001054559.1 126209334 4849766 complement(2101585..2102253) 1 NC_009053.1 D-alanyl-D-alanine carboxypeptidase 2102253 4849766 APL_1872 Actinobacillus pleuropneumoniae serovar 5b str. L20 D-alanyl-D-alanine carboxypeptidase YP_001054559.1 2101585 R 416269 CDS YP_001054560.1 126209335 4849441 complement(2102272..2103405) 1 NC_009053.1 dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica.; succinyl-diaminopimelate desuccinylase 2103405 dapE 4849441 dapE Actinobacillus pleuropneumoniae serovar 5b str. L20 succinyl-diaminopimelate desuccinylase YP_001054560.1 2102272 R 416269 CDS YP_001054561.1 126209336 4849442 complement(2103428..2103778) 1 NC_009053.1 ArsC protein 2103778 arsC 4849442 arsC Actinobacillus pleuropneumoniae serovar 5b str. L20 ArsC protein YP_001054561.1 2103428 R 416269 CDS YP_001054562.1 126209337 4850150 2103986..2104696 1 NC_009053.1 hypothetical protein 2104696 4850150 APL_1875 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054562.1 2103986 D 416269 CDS YP_001054563.1 126209338 4850494 complement(2104747..2105592) 1 NC_009053.1 dihydropteroate synthase 2105592 folP 4850494 folP Actinobacillus pleuropneumoniae serovar 5b str. L20 dihydropteroate synthase YP_001054563.1 2104747 R 416269 CDS YP_001054564.1 126209339 4849513 complement(2105654..2106619) 1 NC_009053.1 catalyzes the transformation of uracil to pseudouracil at nucleotides U955, U2504, and U2580 in 23S rRNA; 23S rRNA pseudouridylate synthase C 2106619 rluC 4849513 rluC Actinobacillus pleuropneumoniae serovar 5b str. L20 23S rRNA pseudouridylate synthase C YP_001054564.1 2105654 R 416269 CDS YP_001054565.1 126209340 4849347 2109487..2110398 1 NC_009053.1 small-conductance mechanosensitive channel 2110398 mscS 4849347 mscS Actinobacillus pleuropneumoniae serovar 5b str. L20 small-conductance mechanosensitive channel YP_001054565.1 2109487 D 416269 CDS YP_001054566.1 126209341 4849605 2110594..2111772 1 NC_009053.1 hypothetical protein 2111772 4849605 APL_1881 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054566.1 2110594 D 416269 CDS YP_001054567.1 126209342 4848947 2111784..2112536 1 NC_009053.1 hypothetical protein 2112536 4848947 APL_1882 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054567.1 2111784 D 416269 CDS YP_001054568.1 126209343 4848948 complement(2112604..2115552) 1 NC_009053.1 protease 3 2115552 ptrA 4848948 ptrA Actinobacillus pleuropneumoniae serovar 5b str. L20 protease 3 YP_001054568.1 2112604 R 416269 CDS YP_001054569.1 126209344 4849210 complement(2115561..2118905) 1 NC_009053.1 exodeoxyribonuclease V subunit gamma 2118905 recC 4849210 recC Actinobacillus pleuropneumoniae serovar 5b str. L20 exodeoxyribonuclease V subunit gamma YP_001054569.1 2115561 R 416269 CDS YP_001054570.1 126209345 4848827 complement(2119010..2119306) 1 NC_009053.1 hypothetical protein 2119306 4848827 APL_1885 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054570.1 2119010 R 416269 CDS YP_001054571.1 126209346 4848828 complement(2119296..2119952) 1 NC_009053.1 hypothetical protein 2119952 4848828 APL_1886 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054571.1 2119296 R 416269 CDS YP_001054572.1 126209347 4849215 complement(2119962..2120495) 1 NC_009053.1 hypothetical protein 2120495 pulJ 4849215 pulJ Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054572.1 2119962 R 416269 CDS YP_001054573.1 126209348 4849727 complement(2120620..2121150) 1 NC_009053.1 hypothetical protein 2121150 pulG 4849727 pulG Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054573.1 2120620 R 416269 CDS YP_001054574.1 126209349 4849568 complement(2121238..2121768) 1 NC_009053.1 catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to 2,3-decenoyl-ACP or 3,4-decenoyl-ACP; 3-hydroxydecanoyl-ACP dehydratase 2121768 fabA 4849568 fabA Actinobacillus pleuropneumoniae serovar 5b str. L20 3-hydroxydecanoyl-ACP dehydratase YP_001054574.1 2121238 R 416269 CDS YP_001054575.1 126209350 4849569 complement(2121879..2123516) 1 NC_009053.1 protease La-like protein 2123516 lonH 4849569 lonH Actinobacillus pleuropneumoniae serovar 5b str. L20 protease La-like protein YP_001054575.1 2121879 R 416269 CDS YP_001054576.1 126209351 4850376 2123601..2124047 1 NC_009053.1 hypothetical protein 2124047 4850376 APL_1891 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054576.1 2123601 D 416269 CDS YP_001054577.1 126209352 4848530 complement(2124119..2124982) 1 NC_009053.1 tryptophanyl-tRNA synthetase 2124982 trpS 4848530 trpS Actinobacillus pleuropneumoniae serovar 5b str. L20 tryptophanyl-tRNA synthetase YP_001054577.1 2124119 R 416269 CDS YP_001054578.1 126209353 4849925 complement(2125286..2125951) 1 NC_009053.1 catalyzes the dephosphorylation of 2-phosphoglycolate to form glycolate and phosphate; phosphoglycolate phosphatase 2125951 gph 4849925 gph Actinobacillus pleuropneumoniae serovar 5b str. L20 phosphoglycolate phosphatase YP_001054578.1 2125286 R 416269 CDS YP_001054579.1 126209354 4849917 complement(2126121..2126351) 1 NC_009053.1 hypothetical protein 2126351 4849917 APL_1894 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054579.1 2126121 R 416269 CDS YP_001054580.1 126209355 4849918 complement(2126510..2127304) 1 NC_009053.1 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein; prolipoprotein diacylglyceryl transferase 2127304 lgt 4849918 lgt Actinobacillus pleuropneumoniae serovar 5b str. L20 prolipoprotein diacylglyceryl transferase YP_001054580.1 2126510 R 416269 CDS YP_001054581.1 126209356 4848532 complement(2127357..2128148) 1 NC_009053.1 hypothetical protein 2128148 4848532 APL_1896 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054581.1 2127357 R 416269 CDS YP_001054582.1 126209357 4848701 complement(2128145..2128765) 1 NC_009053.1 hydrolyzes diadenosine polyphosphate; dinucleoside polyphosphate hydrolase 2128765 nudH 4848701 nudH Actinobacillus pleuropneumoniae serovar 5b str. L20 dinucleoside polyphosphate hydrolase YP_001054582.1 2128145 R 416269 CDS YP_001054583.1 126209358 4848784 complement(2129311..2130078) 1 NC_009053.1 hypothetical protein 2130078 ap2029 4848784 ap2029 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054583.1 2129311 R 416269 CDS YP_001054584.1 126209359 4848785 complement(2130174..2130701) 1 NC_009053.1 catalyzes the hydrolysis of pyrophosphate to phosphate; inorganic pyrophosphatase 2130701 ppa 4848785 ppa Actinobacillus pleuropneumoniae serovar 5b str. L20 inorganic pyrophosphatase YP_001054584.1 2130174 R 416269 CDS YP_001054585.1 126209360 4849626 2130775..2131485 1 NC_009053.1 hypothetical protein 2131485 4849626 APL_1900 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054585.1 2130775 D 416269 CDS YP_001054586.1 126209361 4850450 complement(2131532..2132029) 1 NC_009053.1 regulator of RNase E; increases half-life and abundance of RNAs; interacts with RNase E possibly inhibiting catalytic activity; ribonuclease activity regulator protein RraA 2132029 rraA 4850450 rraA Actinobacillus pleuropneumoniae serovar 5b str. L20 ribonuclease activity regulator protein RraA YP_001054586.1 2131532 R 416269 CDS YP_001054587.1 126209362 4850539 2132332..2133024 1 NC_009053.1 transport protein YrhG 2133024 yrhG 4850539 yrhG Actinobacillus pleuropneumoniae serovar 5b str. L20 transport protein YrhG YP_001054587.1 2132332 D 416269 CDS YP_001054588.1 126209363 4850232 2133195..2134019 1 NC_009053.1 hypothetical protein 2134019 4850232 APL_1903 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054588.1 2133195 D 416269 CDS YP_001054589.1 126209364 4850233 complement(2134138..2134926) 1 NC_009053.1 hypothetical protein 2134926 4850233 APL_1904 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054589.1 2134138 R 416269 CDS YP_001054590.1 126209365 4849429 complement(2135185..2136327) 1 NC_009053.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; chaperone protein DnaJ 2136327 dnaJ 4849429 dnaJ Actinobacillus pleuropneumoniae serovar 5b str. L20 chaperone protein DnaJ YP_001054590.1 2135185 R 416269 CDS YP_001054591.1 126209366 4848587 complement(2136557..2138455) 1 NC_009053.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria; molecular chaperone DnaK 2138455 dnaK 4848587 dnaK Actinobacillus pleuropneumoniae serovar 5b str. L20 molecular chaperone DnaK YP_001054591.1 2136557 R 416269 CDS YP_001054592.1 126209367 4849661 complement(2138730..2140175) 1 NC_009053.1 xylulose kinase 2140175 xylB 4849661 xylB Actinobacillus pleuropneumoniae serovar 5b str. L20 xylulose kinase YP_001054592.1 2138730 R 416269 CDS YP_001054593.1 126209368 4849662 complement(2140373..2141692) 1 NC_009053.1 catalyzes the interconversion of D-xylose to D-xylulose; xylose isomerase 2141692 xylA 4849662 xylA Actinobacillus pleuropneumoniae serovar 5b str. L20 xylose isomerase YP_001054593.1 2140373 R 416269 CDS YP_001054594.1 126209369 4850411 2141946..2142944 1 NC_009053.1 periplasmic substrate-binding component of the ATP-dependent xylose transport system; high affinity; D-xylose transporter subunit XylF 2142944 xylF 4850411 xylF Actinobacillus pleuropneumoniae serovar 5b str. L20 D-xylose transporter subunit XylF YP_001054594.1 2141946 D 416269 CDS YP_001054595.1 126209370 4850412 2143008..2144522 1 NC_009053.1 with XylFH is part of the high affinity xylose ABC transporter; xylose transporter ATP-binding subunit 2144522 xylG 4850412 xylG Actinobacillus pleuropneumoniae serovar 5b str. L20 xylose transporter ATP-binding subunit YP_001054595.1 2143008 D 416269 CDS YP_001054596.1 126209371 4849893 2144526..2145653 1 NC_009053.1 xylose transport system permease xylH 2145653 xylH 4849893 xylH Actinobacillus pleuropneumoniae serovar 5b str. L20 xylose transport system permease xylH YP_001054596.1 2144526 D 416269 CDS YP_001054597.1 126209372 4849894 2145778..2146959 1 NC_009053.1 xylose operon regulatory protein 2146959 xylR 4849894 xylR Actinobacillus pleuropneumoniae serovar 5b str. L20 xylose operon regulatory protein YP_001054597.1 2145778 D 416269 CDS YP_001054598.1 126209373 4849895 2146964..2148991 1 NC_009053.1 neutral endopeptidase 2148991 pepO 4849895 pepO Actinobacillus pleuropneumoniae serovar 5b str. L20 neutral endopeptidase YP_001054598.1 2146964 D 416269 CDS YP_001054599.1 126209374 4849896 2149066..2149293 1 NC_009053.1 hypothetical protein 2149293 4849896 APL_1914 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054599.1 2149066 D 416269 CDS YP_001054600.1 126209375 4849897 complement(2149362..2150774) 1 NC_009053.1 mediates high affinitiy panthothenate transport which is stimulated by the presence of sodium ions; member of SSS family of sodium/solute symporters; the imported panthothenate is phosphorylated by panthothenate kinase; sodium/panthothenate symporter 2150774 panF 4849897 panF Actinobacillus pleuropneumoniae serovar 5b str. L20 sodium/panthothenate symporter YP_001054600.1 2149362 R 416269 CDS YP_001054601.1 126209376 4848626 complement(2150794..2151018) 1 NC_009053.1 hypothetical protein 2151018 ap2048 4848626 ap2048 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054601.1 2150794 R 416269 CDS YP_001054602.1 126209377 4848627 complement(2151070..2151387) 1 NC_009053.1 when combined with S-adenosylmethionine represses the expression of the methionine regulon and of proteins involved in S-adenosylmethionine synthesis; transcriptional repressor protein MetJ 2151387 metJ 4848627 metJ Actinobacillus pleuropneumoniae serovar 5b str. L20 transcriptional repressor protein MetJ YP_001054602.1 2151070 R 416269 CDS YP_001054603.1 126209378 4848628 2151556..2152305 1 NC_009053.1 lipoprotein VacJ-like protein 2152305 vacJ 4848628 vacJ Actinobacillus pleuropneumoniae serovar 5b str. L20 lipoprotein VacJ-like protein YP_001054603.1 2151556 D 416269 CDS YP_001054604.1 126209379 4848629 2152380..2153189 1 NC_009053.1 hypothetical protein 2153189 4848629 APL_1919 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054604.1 2152380 D 416269 CDS YP_001054605.1 126209380 4848630 2153314..2155281 1 NC_009053.1 site-specific recombinase 2155281 4848630 APL_1920 Actinobacillus pleuropneumoniae serovar 5b str. L20 site-specific recombinase YP_001054605.1 2153314 D 416269 CDS YP_001054606.1 126209381 4848631 2156031..2158523 1 NC_009053.1 biofilm PGA synthesis protein PgaA 2158523 pgaA 4848631 pgaA Actinobacillus pleuropneumoniae serovar 5b str. L20 biofilm PGA synthesis protein PgaA YP_001054606.1 2156031 D 416269 CDS YP_001054607.1 126209382 4848632 2158538..2160310 1 NC_009053.1 biofilm PGA synthesis lipoprotein PgaB 2160310 pgaB 4848632 pgaB Actinobacillus pleuropneumoniae serovar 5b str. L20 biofilm PGA synthesis lipoprotein PgaB YP_001054607.1 2158538 D 416269 CDS YP_001054608.1 126209383 4848633 2160319..2161554 1 NC_009053.1 predicted polysaccharide polymerase involved in biofilm formation; required for the synthesis of the beta-1,6-N-acetylglucosamine polysaccharide; PgaC; in Yersinia the HmsR protein is an inner membrane protein; N-glycosyltransferase 2161554 pgaC 4848633 pgaC Actinobacillus pleuropneumoniae serovar 5b str. L20 N-glycosyltransferase YP_001054608.1 2160319 D 416269 CDS YP_001054609.1 126209384 4848634 2161556..2161840 1 NC_009053.1 biofilm PGA synthesis protein pgaD 2161840 pgaD 4848634 pgaD Actinobacillus pleuropneumoniae serovar 5b str. L20 biofilm PGA synthesis protein pgaD YP_001054609.1 2161556 D 416269 CDS YP_001054610.1 126209385 4848635 complement(2161944..2162714) 1 NC_009053.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate; triosephosphate isomerase 2162714 tpiA 4848635 tpiA Actinobacillus pleuropneumoniae serovar 5b str. L20 triosephosphate isomerase YP_001054610.1 2161944 R 416269 CDS YP_001054611.1 126209386 4848636 2162989..2164002 1 NC_009053.1 catalyzes the modification of U13 in tRNA(Glu); tRNA pseudouridine synthase D 2164002 truD 4848636 truD Actinobacillus pleuropneumoniae serovar 5b str. L20 tRNA pseudouridine synthase D YP_001054611.1 2162989 D 416269 CDS YP_001054612.1 126209387 4849446 2164002..2164766 1 NC_009053.1 catalyzes the conversion of a phosphate monoester to an alcohol and a phosphate; stationary phase survival protein SurE 2164766 surE 4849446 surE Actinobacillus pleuropneumoniae serovar 5b str. L20 stationary phase survival protein SurE YP_001054612.1 2164002 D 416269 CDS YP_001054613.1 126209388 4849447 2164766..2165350 1 NC_009053.1 hypothetical protein 2165350 4849447 APL_1928 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054613.1 2164766 D 416269 CDS YP_001054614.1 126209389 4849448 2165362..2165937 1 NC_009053.1 lipoprotein 2165937 4849448 APL_1929 Actinobacillus pleuropneumoniae serovar 5b str. L20 lipoprotein YP_001054614.1 2165362 D 416269 CDS YP_001054615.1 126209390 4849449 2166254..2167492 1 NC_009053.1 Outer membrane antigenic lipoprotein B 2167492 4849449 APL_1930 Actinobacillus pleuropneumoniae serovar 5b str. L20 Outer membrane antigenic lipoprotein B YP_001054615.1 2166254 D 416269 CDS YP_001054616.1 126209391 4849450 2167581..2168144 1 NC_009053.1 3-methyladenine DNA glycosylase 2168144 tagI 4849450 tagI Actinobacillus pleuropneumoniae serovar 5b str. L20 3-methyladenine DNA glycosylase YP_001054616.1 2167581 D 416269 CDS YP_001054617.1 126209392 4849452 complement(2169338..2169802) 1 NC_009053.1 hypothetical protein 2169802 4849452 APL_1934 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054617.1 2169338 R 416269 CDS YP_001054618.1 126209393 4849453 complement(2169799..2170224) 1 NC_009053.1 hypothetical protein 2170224 4849453 APL_1935 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054618.1 2169799 R 416269 CDS YP_001054619.1 126209394 4849454 complement(2170294..2170437) 1 NC_009053.1 hypothetical protein 2170437 4849454 APL_1936 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054619.1 2170294 R 416269 CDS YP_001054620.1 126209395 4850278 complement(2170615..2171574) 1 NC_009053.1 ferrochelatase 2171574 hemH 4850278 hemH Actinobacillus pleuropneumoniae serovar 5b str. L20 ferrochelatase YP_001054620.1 2170615 R 416269 CDS YP_001054621.1 126209396 4850279 2171850..2171984 1 NC_009053.1 in Escherichia coli transcription of this gene is enhanced by polyamines; 50S ribosomal protein L34 2171984 rpmH 4850279 rpmH Actinobacillus pleuropneumoniae serovar 5b str. L20 50S ribosomal protein L34 YP_001054621.1 2171850 D 416269 CDS YP_001054622.1 126209397 4850280 2172077..2172379 1 NC_009053.1 protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates; ribonuclease P 2172379 rnpA 4850280 rnpA Actinobacillus pleuropneumoniae serovar 5b str. L20 ribonuclease P YP_001054622.1 2172077 D 416269 CDS YP_001054623.1 126209398 4850281 2172340..2172642 1 NC_009053.1 hypothetical protein 2172642 4850281 APL_1940 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054623.1 2172340 D 416269 CDS YP_001054624.1 126209399 4850282 complement(2172693..2174108) 1 NC_009053.1 glutamine synthetase 2174108 glnA 4850282 glnA Actinobacillus pleuropneumoniae serovar 5b str. L20 glutamine synthetase YP_001054624.1 2172693 R 416269 CDS YP_001054625.1 126209400 4850283 complement(2174466..2175293) 1 NC_009053.1 cyclic 3',5'-adenosine monophosphate phosphodiesterase 2175293 icc 4850283 icc Actinobacillus pleuropneumoniae serovar 5b str. L20 cyclic 3',5'-adenosine monophosphate phosphodiesterase YP_001054625.1 2174466 R 416269 CDS YP_001054626.1 126209401 4850284 complement(2175500..2176123) 1 NC_009053.1 ADP-ribose pyrophosphatase 2176123 4850284 APL_1943 Actinobacillus pleuropneumoniae serovar 5b str. L20 ADP-ribose pyrophosphatase YP_001054626.1 2175500 R 416269 CDS YP_001054627.1 126209402 4850285 complement(2176133..2176552) 1 NC_009053.1 phosphate-starvation-inducible protein PsiE 2176552 4850285 APL_1944 Actinobacillus pleuropneumoniae serovar 5b str. L20 phosphate-starvation-inducible protein PsiE YP_001054627.1 2176133 R 416269 CDS YP_001054628.1 126209403 4850286 complement(2176545..2177273) 1 NC_009053.1 hypothetical protein 2177273 4850286 APL_1945 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054628.1 2176545 R 416269 CDS YP_001054629.1 126209404 4850287 complement(2177333..2177761) 1 NC_009053.1 hypothetical protein 2177761 4850287 APL_1946 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054629.1 2177333 R 416269 CDS YP_001054630.1 126209405 4848576 2177937..2179121 1 NC_009053.1 exports sodium by using the electrochemical proton gradient to allow protons into the cell; functions in adaptation to high salinity and alkaline pH; activity increases at higher pH; downregulated at acidic pH; pH-dependent sodium/proton antiporter 2179121 nhaA 4848576 nhaA Actinobacillus pleuropneumoniae serovar 5b str. L20 pH-dependent sodium/proton antiporter YP_001054630.1 2177937 D 416269 CDS YP_001054631.1 126209406 4848577 2179264..2179752 1 NC_009053.1 hypothetical protein 2179752 4848577 APL_1948 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054631.1 2179264 D 416269 CDS YP_001054632.1 126209407 4848578 complement(2179788..2180222) 1 NC_009053.1 hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine; D-tyrosyl-tRNA(Tyr) deacylase 2180222 dtd 4848578 dtd Actinobacillus pleuropneumoniae serovar 5b str. L20 D-tyrosyl-tRNA(Tyr) deacylase YP_001054632.1 2179788 R 416269 CDS YP_001054633.1 126209408 4848579 complement(2180219..2181049) 1 NC_009053.1 RNase BN; required for 3' maturation of certain phage T4-encoded tRNAs; forms a dimer; specific for immature tRNA substrates containing incorrect residues within the universal CCA sequence; 3' to 5' exoribonuclease; ribonuclease BN 2181049 rbn 4848579 rbn Actinobacillus pleuropneumoniae serovar 5b str. L20 ribonuclease BN YP_001054633.1 2180219 R 416269 CDS YP_001054634.1 126209409 4848580 complement(2181067..2182305) 1 NC_009053.1 Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway; gamma-glutamyl phosphate reductase 2182305 proA 4848580 proA Actinobacillus pleuropneumoniae serovar 5b str. L20 gamma-glutamyl phosphate reductase YP_001054634.1 2181067 R 416269 CDS YP_001054635.1 126209410 4848582 complement(2184989..2185945) 1 NC_009053.1 hypothetical protein 2185945 4848582 APL_1956 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054635.1 2184989 R 416269 CDS YP_001054636.1 126209411 4848583 complement(2185963..2187207) 1 NC_009053.1 Lipoprotein_5 domain-containing protein 2187207 4848583 APL_1957 Actinobacillus pleuropneumoniae serovar 5b str. L20 Lipoprotein_5 domain-containing protein YP_001054636.1 2185963 R 416269 CDS YP_001054637.1 126209412 4848584 2187521..2189389 1 NC_009053.1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex; DNA mismatch repair protein 2189389 mutL 4848584 mutL Actinobacillus pleuropneumoniae serovar 5b str. L20 DNA mismatch repair protein YP_001054637.1 2187521 D 416269 CDS YP_001054638.1 126209413 4848585 2189591..2190640 1 NC_009053.1 similar to zinc-dependent eukaryotic ADH enzymes and distinct from fermentative ADHs; alcohol dehydrogenase 2190640 adhI 4848585 adhI Actinobacillus pleuropneumoniae serovar 5b str. L20 alcohol dehydrogenase YP_001054638.1 2189591 D 416269 CDS YP_001054639.1 126209414 4849962 2190802..2191716 1 NC_009053.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity; tRNA delta(2)-isopentenylpyrophosphate transferase 2191716 miaA 4849962 miaA Actinobacillus pleuropneumoniae serovar 5b str. L20 tRNA delta(2)-isopentenylpyrophosphate transferase YP_001054639.1 2190802 D 416269 CDS YP_001054640.1 126209415 4849963 2191781..2192059 1 NC_009053.1 RNA-binding protein Hfq 2192059 hfq 4849963 hfq Actinobacillus pleuropneumoniae serovar 5b str. L20 RNA-binding protein Hfq YP_001054640.1 2191781 D 416269 CDS YP_001054641.1 126209416 4849964 2192241..2193464 1 NC_009053.1 GTP-binding protein hflX 2193464 hflX 4849964 hflX Actinobacillus pleuropneumoniae serovar 5b str. L20 GTP-binding protein hflX YP_001054641.1 2192241 D 416269 CDS YP_001054642.1 126209417 4849965 complement(2193500..2194060) 1 NC_009053.1 hypothetical protein 2194060 4849965 APL_1963 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054642.1 2193500 R 416269 CDS YP_001054643.1 126209418 4849966 2194123..2194446 1 NC_009053.1 hypothetical protein 2194446 4849966 APL_1964 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054643.1 2194123 D 416269 CDS YP_001054644.1 126209419 4849967 complement(2194502..2195182) 1 NC_009053.1 complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons; cAMP-regulatory protein 2195182 crp 4849967 crp Actinobacillus pleuropneumoniae serovar 5b str. L20 cAMP-regulatory protein YP_001054644.1 2194502 R 416269 CDS YP_001054645.1 126209420 4849968 complement(2195254..2195472) 1 NC_009053.1 hypothetical protein 2195472 4849968 APL_1966 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054645.1 2195254 R 416269 CDS YP_001054646.1 126209421 4849969 complement(2195478..2196086) 1 NC_009053.1 FtsZ binding protein; synthetically lethal with a defect in the Min system; this protein is the first identified nucleoid occlusion factor which works along with the Min system to properly position the FtsZ ring assembly; nucleoid occlusion protein 2196086 slmA 4849969 slmA Actinobacillus pleuropneumoniae serovar 5b str. L20 nucleoid occlusion protein YP_001054646.1 2195478 R 416269 CDS YP_001054647.1 126209422 4849970 complement(2196192..2196647) 1 NC_009053.1 catalyzes the formation of dUMP from dUTP; deoxyuridine 5'-triphosphate nucleotidohydrolase 2196647 dut 4849970 dut Actinobacillus pleuropneumoniae serovar 5b str. L20 deoxyuridine 5'-triphosphate nucleotidohydrolase YP_001054647.1 2196192 R 416269 CDS YP_001054648.1 126209423 4849971 complement(2196656..2197861) 1 NC_009053.1 catalyzes the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, which is then decarboxylated to form 4'-phosphopantotheine; bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase 2197861 dfp 4849971 dfp Actinobacillus pleuropneumoniae serovar 5b str. L20 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase YP_001054648.1 2196656 R 416269 CDS YP_001054649.1 126209424 4848589 2198069..2198731 1 NC_009053.1 Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase; DNA repair protein RadC 2198731 radC 4848589 radC Actinobacillus pleuropneumoniae serovar 5b str. L20 DNA repair protein RadC YP_001054649.1 2198069 D 416269 CDS YP_001054650.1 126209425 4848590 2198900..2199136 1 NC_009053.1 required for 70S ribosome assembly; 50S ribosomal protein L28 2199136 rpmB 4848590 rpmB Actinobacillus pleuropneumoniae serovar 5b str. L20 50S ribosomal protein L28 YP_001054650.1 2198900 D 416269 CDS YP_001054651.1 126209426 4848591 2199148..2199318 1 NC_009053.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 2199318 rpmG 4848591 rpmG Actinobacillus pleuropneumoniae serovar 5b str. L20 50S ribosomal protein L33 YP_001054651.1 2199148 D 416269 CDS YP_001054652.1 126209427 4848592 2199731..2200291 1 NC_009053.1 hypothetical protein 2200291 4848592 APL_1973 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054652.1 2199731 D 416269 CDS YP_001054653.1 126209428 4848593 2200641..2201936 1 NC_009053.1 catalyzes the reversible formation of diaminobutyrate and 2-oxoglutarate from glutamate and L-aspartic beta-semialdehyde; diaminobutyrate--2-oxoglutarate aminotransferase 2201936 argD 4848593 argD Actinobacillus pleuropneumoniae serovar 5b str. L20 diaminobutyrate--2-oxoglutarate aminotransferase YP_001054653.1 2200641 D 416269 CDS YP_001054654.1 126209429 4848594 2202065..2203600 1 NC_009053.1 L-2,4-diaminobutyrate decarboxylase 2203600 ddc 4848594 ddc Actinobacillus pleuropneumoniae serovar 5b str. L20 L-2,4-diaminobutyrate decarboxylase YP_001054654.1 2202065 D 416269 CDS YP_001054655.1 126209430 4848595 complement(2203659..2203928) 1 NC_009053.1 hypothetical protein 2203928 yedF 4848595 yedF Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054655.1 2203659 R 416269 CDS YP_001054656.1 126209431 4848596 complement(2203946..2205166) 1 NC_009053.1 inner membrane protein 2205166 yedE 4848596 yedE Actinobacillus pleuropneumoniae serovar 5b str. L20 inner membrane protein YP_001054656.1 2203946 R 416269 CDS YP_001054657.1 126209432 4848597 2205462..2205794 1 NC_009053.1 hypothetical protein 2205794 4848597 APL_1978 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054657.1 2205462 D 416269 CDS YP_001054658.1 126209433 4848598 2205957..2207063 1 NC_009053.1 catalyzes the formation of 5-methyl-uridine at position 54 in all tRNAs; tRNA (uracil-5-)-methyltransferase 2207063 trmA 4848598 trmA Actinobacillus pleuropneumoniae serovar 5b str. L20 tRNA (uracil-5-)-methyltransferase YP_001054658.1 2205957 D 416269 CDS YP_001054659.1 126209434 4849530 complement(2207584..2208186) 1 NC_009053.1 hypothetical protein 2208186 4849530 APL_1980 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054659.1 2207584 R 416269 CDS YP_001054660.1 126209435 4849531 complement(2208647..2209600) 1 NC_009053.1 responsible for the influx of magnesium ions; magnesium/nickel/cobalt transporter CorA 2209600 corA 4849531 corA Actinobacillus pleuropneumoniae serovar 5b str. L20 magnesium/nickel/cobalt transporter CorA YP_001054660.1 2208647 R 416269 CDS YP_001054661.1 126209436 4849532 2209901..2210677 1 NC_009053.1 ubiquinone/menaquinone biosynthesis methyltransferase ubiE 2210677 ubiE 4849532 ubiE Actinobacillus pleuropneumoniae serovar 5b str. L20 ubiquinone/menaquinone biosynthesis methyltransferase ubiE YP_001054661.1 2209901 D 416269 CDS YP_001054662.1 126209437 4849533 2210703..2211335 1 NC_009053.1 hypothetical protein 2211335 4849533 APL_1983 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054662.1 2210703 D 416269 CDS YP_001054663.1 126209438 4849534 2211332..2212966 1 NC_009053.1 ubiquinone biosynthesis protein ubiB 2212966 ubiB 4849534 ubiB Actinobacillus pleuropneumoniae serovar 5b str. L20 ubiquinone biosynthesis protein ubiB YP_001054663.1 2211332 D 416269 CDS YP_001054664.1 126209439 4849535 2213058..2213288 1 NC_009053.1 TatA; similar to TatE that is found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes; twin arginine translocase protein A 2213288 tatA 4849535 tatA Actinobacillus pleuropneumoniae serovar 5b str. L20 twin arginine translocase protein A YP_001054664.1 2213058 D 416269 CDS YP_001054665.1 126209440 4849536 2213292..2213879 1 NC_009053.1 mediates the export of protein precursors bearing twin-arginine signal peptides; sec-independent translocase 2213879 tatB 4849536 tatB Actinobacillus pleuropneumoniae serovar 5b str. L20 sec-independent translocase YP_001054665.1 2213292 D 416269 CDS YP_001054666.1 126209441 4850092 2214043..2214615 1 NC_009053.1 Sec-independent protein translocase protein tatC 2214615 tatC 4850092 tatC Actinobacillus pleuropneumoniae serovar 5b str. L20 Sec-independent protein translocase protein tatC YP_001054666.1 2214043 D 416269 CDS YP_001054667.1 126209442 4850093 2214675..2215694 1 NC_009053.1 catalyzes the formation of porphobilinogen from 5-aminolevulinate; delta-aminolevulinic acid dehydratase 2215694 hemB 4850093 hemB Actinobacillus pleuropneumoniae serovar 5b str. L20 delta-aminolevulinic acid dehydratase YP_001054667.1 2214675 D 416269 CDS YP_001054668.1 126209443 4850094 2215781..2216143 1 NC_009053.1 hypothetical protein 2216143 4850094 APL_1989 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054668.1 2215781 D 416269 CDS YP_001054669.1 126209444 4850095 complement(2216194..2217015) 1 NC_009053.1 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases; formamidopyrimidine-DNA glycosylase 2217015 mutM 4850095 mutM Actinobacillus pleuropneumoniae serovar 5b str. L20 formamidopyrimidine-DNA glycosylase YP_001054669.1 2216194 R 416269 CDS YP_001054670.1 126209445 4850096 complement(2217078..2218370) 1 NC_009053.1 branched chain amino acid ABC transporter carrier protein 2218370 brnQ 4850096 brnQ Actinobacillus pleuropneumoniae serovar 5b str. L20 branched chain amino acid ABC transporter carrier protein YP_001054670.1 2217078 R 416269 CDS YP_001054671.1 126209446 4850097 complement(2218496..2219221) 1 NC_009053.1 catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 2219221 fabG 4850097 fabG Actinobacillus pleuropneumoniae serovar 5b str. L20 3-ketoacyl-ACP reductase YP_001054671.1 2218496 R 416269 CDS YP_001054672.1 126209447 4850098 complement(2219340..2220275) 1 NC_009053.1 malonyl CoA-acyl carrier protein transacylase 2220275 fabD 4850098 fabD Actinobacillus pleuropneumoniae serovar 5b str. L20 malonyl CoA-acyl carrier protein transacylase YP_001054672.1 2219340 R 416269 CDS YP_001054673.1 126209448 4850099 complement(2220342..2221088) 1 NC_009053.1 hypothetical protein 2221088 4850099 APL_1994 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054673.1 2220342 R 416269 CDS YP_001054674.1 126209449 4850100 complement(2221125..2222120) 1 NC_009053.1 octaprenyl-diphosphate synthase 2222120 ispB 4850100 ispB Actinobacillus pleuropneumoniae serovar 5b str. L20 octaprenyl-diphosphate synthase YP_001054674.1 2221125 R 416269 CDS YP_001054675.1 126209450 4850101 2222409..2223227 1 NC_009053.1 hypothetical protein 2223227 rssA 4850101 rssA Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054675.1 2222409 D 416269 CDS YP_001054676.1 126209451 4848813 2223391..2223942 1 NC_009053.1 hypothetical protein 2223942 4848813 APL_1997 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054676.1 2223391 D 416269 CDS YP_001054677.1 126209452 4848814 2224143..2224556 1 NC_009053.1 hypothetical protein 2224556 4848814 APL_1998 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054677.1 2224143 D 416269 CDS YP_001054678.1 126209453 4848815 2224909..2225220 1 NC_009053.1 50S ribosomal protein L21 2225220 rplU 4848815 rplU Actinobacillus pleuropneumoniae serovar 5b str. L20 50S ribosomal protein L21 YP_001054678.1 2224909 D 416269 CDS YP_001054679.1 126209454 4848816 2225241..2225498 1 NC_009053.1 involved in the peptidyltransferase reaction during translation; 50S ribosomal protein L27 2225498 rpmA 4848816 rpmA Actinobacillus pleuropneumoniae serovar 5b str. L20 50S ribosomal protein L27 YP_001054679.1 2225241 D 416269 CDS YP_001054680.1 126209455 4848817 2225578..2226522 1 NC_009053.1 hypothetical protein 2226522 4848817 APL_2001 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054680.1 2225578 D 416269 CDS YP_001054681.1 126209456 4848818 complement(2226751..2228220) 1 NC_009053.1 hypothetical protein 2228220 4848818 APL_2002 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054681.1 2226751 R 416269 CDS YP_001054682.1 126209457 4848819 complement(2228336..2229145) 1 NC_009053.1 hypothetical protein 2229145 ap2140 4848819 ap2140 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054682.1 2228336 R 416269 CDS YP_001054683.1 126209458 4848820 2229265..2229942 1 NC_009053.1 competence protein F 2229942 comF 4848820 comF Actinobacillus pleuropneumoniae serovar 5b str. L20 competence protein F YP_001054683.1 2229265 D 416269 CDS YP_001054684.1 126209459 4848821 complement(2230377..2231366) 1 NC_009053.1 16S rRNA M2G1207 methyltransferase; one of many enzymes that modify bases of the ribosomal RNA; this enzyme methylates the G at position 1207 of the small ribosomal subunit; 16S ribosomal RNA m2G1207 methyltransferase 2231366 rsmC 4848821 rsmC Actinobacillus pleuropneumoniae serovar 5b str. L20 16S ribosomal RNA m2G1207 methyltransferase YP_001054684.1 2230377 R 416269 CDS YP_001054685.1 126209460 4848822 2231501..2231893 1 NC_009053.1 with the chi subunit binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB; DNA polymerase III subunit psi 2231893 holD 4848822 holD Actinobacillus pleuropneumoniae serovar 5b str. L20 DNA polymerase III subunit psi YP_001054685.1 2231501 D 416269 CDS YP_001054686.1 126209461 4850508 2231886..2232323 1 NC_009053.1 alanine acetyltransferase that specifically acetylates ribosomal protein S18; ribosomal-protein-alanine N-acetyltransferase 2232323 rimI 4850508 rimI Actinobacillus pleuropneumoniae serovar 5b str. L20 ribosomal-protein-alanine N-acetyltransferase YP_001054686.1 2231886 D 416269 CDS YP_001054687.1 126209462 4850509 2232346..2233683 1 NC_009053.1 facilitates an early step in the assembly of the 50S subunit of the ribosome; ATP-dependent RNA helicase SrmB 2233683 srmB 4850509 srmB Actinobacillus pleuropneumoniae serovar 5b str. L20 ATP-dependent RNA helicase SrmB YP_001054687.1 2232346 D 416269 CDS YP_001054688.1 126209463 4850510 2233758..2234387 1 NC_009053.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate; pyridoxamine 5'-phosphate oxidase 2234387 pdxH 4850510 pdxH Actinobacillus pleuropneumoniae serovar 5b str. L20 pyridoxamine 5'-phosphate oxidase YP_001054688.1 2233758 D 416269 CDS YP_001054689.1 126209464 4850511 complement(2234459..2236096) 1 NC_009053.1 heme-binding protein A 2236096 hbpA 4850511 hbpA Actinobacillus pleuropneumoniae serovar 5b str. L20 heme-binding protein A YP_001054689.1 2234459 R 416269 CDS YP_001054690.1 126209465 4850512 complement(2236287..2237768) 1 NC_009053.1 aldehyde dehydrogenase aldA 2237768 aldA 4850512 aldA Actinobacillus pleuropneumoniae serovar 5b str. L20 aldehyde dehydrogenase aldA YP_001054690.1 2236287 R 416269 CDS YP_001054691.1 126209466 4850513 complement(2237974..2238543) 1 NC_009053.1 hypothetical protein 2238543 4850513 APL_2012 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054691.1 2237974 R 416269 CDS YP_001054692.1 126209467 4850514 2238869..2239549 1 NC_009053.1 ferrichrome ABC transporter ATP-binding protein 2239549 fhuC 4850514 fhuC Actinobacillus pleuropneumoniae serovar 5b str. L20 ferrichrome ABC transporter ATP-binding protein YP_001054692.1 2238869 D 416269 CDS YP_001054693.1 126209468 4850515 2239666..2240505 1 NC_009053.1 similar to Haemophilus parasuis FhuD; ABC-type Fe3+-hydroxamate transport system, periplasmic component; FhuD 2240505 4850515 APL_2014 Actinobacillus pleuropneumoniae serovar 5b str. L20 ABC-type Fe3+-hydroxamate transport system, periplasmic component; FhuD YP_001054693.1 2239666 D 416269 CDS YP_001054694.1 126209469 4850516 2240499..2242451 1 NC_009053.1 part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter involved in the high-affinity transport of Fe(3+)-ferrichrome; iron-hydroxamate transporter permease subunit 2242451 fhuB 4850516 fhuB Actinobacillus pleuropneumoniae serovar 5b str. L20 iron-hydroxamate transporter permease subunit YP_001054694.1 2240499 D 416269 CDS YP_001054695.1 126209470 4850517 2242636..2244489 1 NC_009053.1 ferrioxamine B receptor 2244489 4850517 APL_2016 Actinobacillus pleuropneumoniae serovar 5b str. L20 ferrioxamine B receptor YP_001054695.1 2242636 D 416269 CDS YP_001054696.1 126209471 4850115 2244556..2244873 1 NC_009053.1 hypothetical protein 2244873 4850115 APL_2017 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054696.1 2244556 D 416269 CDS YP_001054697.1 126209472 4850116 complement(2244964..2245821) 1 NC_009053.1 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase; phosphoribosylaminoimidazolesuccinocarboxamide synthase 2245821 purC 4850116 purC Actinobacillus pleuropneumoniae serovar 5b str. L20 phosphoribosylaminoimidazolesuccinocarboxamide synthase YP_001054697.1 2244964 R 416269 CDS YP_001054698.1 126209473 4850117 2246191..2247090 1 NC_009053.1 long form of enzyme; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms active dimers and inactive hexamers which is dependent on concentration of substrates and inhibitors; ATP phosphoribosyltransferase 2247090 hisG 4850117 hisG Actinobacillus pleuropneumoniae serovar 5b str. L20 ATP phosphoribosyltransferase YP_001054698.1 2246191 D 416269 CDS YP_001054699.1 126209474 4850118 2247206..2248492 1 NC_009053.1 catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer; histidinol dehydrogenase 2248492 hisD 4850118 hisD Actinobacillus pleuropneumoniae serovar 5b str. L20 histidinol dehydrogenase YP_001054699.1 2247206 D 416269 CDS YP_001054700.1 126209475 4850119 2248616..2249668 1 NC_009053.1 catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis; histidinol-phosphate aminotransferase 2249668 hisC 4850119 hisC Actinobacillus pleuropneumoniae serovar 5b str. L20 histidinol-phosphate aminotransferase YP_001054700.1 2248616 D 416269 CDS YP_001054701.1 126209476 4850120 2249794..2250234 1 NC_009053.1 transposase IS200 2250234 4850120 APL_2022 Actinobacillus pleuropneumoniae serovar 5b str. L20 transposase IS200 YP_001054701.1 2249794 D 416269 CDS YP_001054702.1 126209477 4850121 2250366..2251457 1 NC_009053.1 catalyzes the formation of 3-(imidazol-4-yl)-2-oxopropyl phosphate from D-ethythro-1-(imidazol-4-yl)glycerol 3-phosphate and histidinol from histidinol phosphate; imidazole glycerol-phosphate dehydratase/histidinol phosphatase 2251457 hisB 4850121 hisB Actinobacillus pleuropneumoniae serovar 5b str. L20 imidazole glycerol-phosphate dehydratase/histidinol phosphatase YP_001054702.1 2250366 D 416269 CDS YP_001054703.1 126209478 4850122 2252274..2253059 1 NC_009053.1 hypothetical protein 2253059 4850122 APL_2024 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054703.1 2252274 D 416269 CDS YP_001054704.1 126209479 4850123 2253185..2253775 1 NC_009053.1 with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide; imidazole glycerol phosphate synthase subunit HisH 2253775 hisH 4850123 hisH Actinobacillus pleuropneumoniae serovar 5b str. L20 imidazole glycerol phosphate synthase subunit HisH YP_001054704.1 2253185 D 416269 CDS YP_001054705.1 126209480 4850124 2253896..2254648 1 NC_009053.1 catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide; 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase 2254648 hisA 4850124 hisA Actinobacillus pleuropneumoniae serovar 5b str. L20 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase YP_001054705.1 2253896 D 416269 CDS YP_001054706.1 126209481 4849042 2254771..2255403 1 NC_009053.1 imidazole glycerol phosphate synthase subunit HisF 2255403 hisF 4849042 hisF Actinobacillus pleuropneumoniae serovar 5b str. L20 imidazole glycerol phosphate synthase subunit HisF YP_001054706.1 2254771 D 416269 CDS YP_001054707.1 126209482 4849043 2255532..2256176 1 NC_009053.1 catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribosyl)-ATP and the subsequent formation of 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide from 1-(5-phosphoribosyl)-AMP in histidine biosynthesis; bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase 2256176 hisI 4849043 hisI Actinobacillus pleuropneumoniae serovar 5b str. L20 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase YP_001054707.1 2255532 D 416269 CDS YP_001054708.1 126209483 4849044 2256297..2256962 1 NC_009053.1 hypothetical protein 2256962 4849044 APL_2029 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054708.1 2256297 D 416269 CDS YP_001054709.1 126209484 4849045 2257069..2257875 1 NC_009053.1 catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn; methionine aminopeptidase 2257875 map 4849045 map Actinobacillus pleuropneumoniae serovar 5b str. L20 methionine aminopeptidase YP_001054709.1 2257069 D 416269 CDS YP_001054710.1 126209485 4849046 complement(2257942..2258436) 1 NC_009053.1 hypothetical protein 2258436 4849046 APL_2031 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054710.1 2257942 R 416269 CDS YP_001054711.1 126209486 4849047 complement(2258469..2259488) 1 NC_009053.1 sucrose operon repressor (Scr operon regulatory protein) 2259488 scrR 4849047 scrR Actinobacillus pleuropneumoniae serovar 5b str. L20 sucrose operon repressor (Scr operon regulatory protein) YP_001054711.1 2258469 R 416269 CDS YP_001054712.1 126209487 4849048 complement(2259559..2260995) 1 NC_009053.1 sucrose-6-phosphate hydrolase (Sucrase) (invertase) 2260995 scrB 4849048 scrB Actinobacillus pleuropneumoniae serovar 5b str. L20 sucrose-6-phosphate hydrolase (Sucrase) (invertase) YP_001054712.1 2259559 R 416269 CDS YP_001054713.1 126209488 4849049 complement(2261049..2261972) 1 NC_009053.1 phosphorylates aminoimidazole ribotide (AIR) which forms 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate (HMP-P); synthesis of HMP-P from AIR is complex and requires the product of thiC gene at least; aminoimidazole riboside kinase 2261972 scrK 4849049 scrK Actinobacillus pleuropneumoniae serovar 5b str. L20 aminoimidazole riboside kinase YP_001054713.1 2261049 R 416269 CDS YP_001054714.1 126209489 4849050 2262184..2263194 1 NC_009053.1 copper-containing nitrite reductase 2263194 sufI 4849050 sufI Actinobacillus pleuropneumoniae serovar 5b str. L20 copper-containing nitrite reductase YP_001054714.1 2262184 D 416269 CDS YP_001054715.1 126209490 4849051 complement(2263265..2264515) 1 NC_009053.1 part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane; outer membrane-specific lipoprotein transporter subunit LolE 2264515 lolE 4849051 lolE Actinobacillus pleuropneumoniae serovar 5b str. L20 outer membrane-specific lipoprotein transporter subunit LolE YP_001054715.1 2263265 R 416269 CDS YP_001054716.1 126209491 4848904 complement(2264515..2265228) 1 NC_009053.1 lipoprotein-releasing system ATP-binding protein lolD 2265228 lolD 4848904 lolD Actinobacillus pleuropneumoniae serovar 5b str. L20 lipoprotein-releasing system ATP-binding protein lolD YP_001054716.1 2264515 R 416269 CDS YP_001054717.1 126209492 4848905 complement(2265296..2266468) 1 NC_009053.1 lipoprotein-releasing system transmembrane protein lolC 2266468 lolC 4848905 lolC Actinobacillus pleuropneumoniae serovar 5b str. L20 lipoprotein-releasing system transmembrane protein lolC YP_001054717.1 2265296 R 416269 CDS YP_001054718.1 126209493 4848906 complement(2266593..2267543) 1 NC_009053.1 Catalyzes the reduction of hydroxypyruvate to form D-glycerate, using NADH as an electron donor; glycerate dehydrogenase 2267543 ldhA 4848906 ldhA Actinobacillus pleuropneumoniae serovar 5b str. L20 glycerate dehydrogenase YP_001054718.1 2266593 R 416269 CDS YP_001054719.1 126209494 4848907 complement(2267599..2268453) 1 NC_009053.1 catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis; 2-dehydro-3-deoxyphosphooctonate aldolase 2268453 kdsA 4848907 kdsA Actinobacillus pleuropneumoniae serovar 5b str. L20 2-dehydro-3-deoxyphosphooctonate aldolase YP_001054719.1 2267599 R 416269 CDS YP_001054720.1 126209495 4848908 complement(2268504..2269370) 1 NC_009053.1 hypothetical protein 2269370 4848908 APL_2041 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054720.1 2268504 R 416269 CDS YP_001054721.1 126209496 4848909 complement(2269371..2270243) 1 NC_009053.1 similar to M.PmuHemKP; HemK-like protein 2270243 hemK 4848909 hemK Actinobacillus pleuropneumoniae serovar 5b str. L20 HemK-like protein YP_001054721.1 2269371 R 416269 CDS YP_001054722.1 126209497 4848910 complement(2270245..2270772) 1 NC_009053.1 hypothetical protein 2270772 4848910 APL_2043 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054722.1 2270245 R 416269 CDS YP_001054723.1 126209498 4848911 complement(2270835..2271836) 1 NC_009053.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2; peptide chain release factor 1 2271836 prfA 4848911 prfA Actinobacillus pleuropneumoniae serovar 5b str. L20 peptide chain release factor 1 YP_001054723.1 2270835 R 416269 CDS YP_001054724.1 126209499 4848912 complement(2272069..2273439) 1 NC_009053.1 thiosulfate sulfurtransferase 2273439 sseA 4848912 sseA Actinobacillus pleuropneumoniae serovar 5b str. L20 thiosulfate sulfurtransferase YP_001054724.1 2272069 R 416269 CDS YP_001054725.1 126209500 4848913 complement(2273448..2274440) 1 NC_009053.1 hypothetical protein 2274440 4848913 APL_2046 Actinobacillus pleuropneumoniae serovar 5b str. L20 hypothetical protein YP_001054725.1 2273448 R 416269 CDS