-- dump date 20140618_191108 -- class Genbank::Feature -- table feature -- table main -- field 1 id -- field 2 type -- field 3 name -- field 4 contig -- field 5 start_pos -- field 6 end_pos -- field 7 strand -- field 8 description -- field 9 chrom_position -- field 10 organism -- field 11 GeneID -- header -- id type name contig start_pos end_pos strand description chrom_position organism GeneID 416269000001 SEQ_END SEQ_END NC_009053.1 2274482 2274482 DR NC_009053.1; contig end 2274482..2274482 Actinobacillus pleuropneumoniae serovar 5b str. L20 YP_001052714.1 CDS dnaA NC_009053.1 63 1547 D binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.; chromosomal replication initiation protein 63..1547 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848864 YP_001052715.1 CDS dnaN NC_009053.1 1564 2667 D binds the polymerase to DNA and acts as a sliding clamp; DNA polymerase III subunit beta 1564..2667 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848723 YP_001052716.1 CDS recF NC_009053.1 3001 4083 D Required for DNA replication; binds preferentially to single-stranded, linear DNA; recombination protein F 3001..4083 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848972 YP_001052717.1 CDS sodC NC_009053.1 4139 4711 R superoxide dismutase complement(4139..4711) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850277 YP_001052718.1 CDS asd NC_009053.1 4894 6006 D catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde; aspartate-semialdehyde dehydrogenase 4894..6006 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848944 YP_001052719.1 CDS ompP2A NC_009053.1 6134 7264 R outer membrane protein P2 complement(6134..7264) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849612 YP_001052720.1 CDS lpxB NC_009053.1 7413 8594 D catalyzes the formation of lipid A disaccharide from UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate, lipid A disaccharide is a precursor of lipid A that anchors LPS to the OM; lipid-A-disaccharide synthase 7413..8594 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850465 YP_001052721.1 CDS sohB NC_009053.1 8624 9679 D SohB; periplasmic protein; member of the peptidase S49 family; periplasmic protease 8624..9679 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849517 YP_001052722.1 CDS APL_0009 NC_009053.1 9914 10372 D MraZ; UPF0040; crystal structure shows similarity to AbrB; cell division protein MraZ 9914..10372 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848558 YP_001052723.1 CDS mraW NC_009053.1 10398 11339 D S-adenosyl-methyltransferase MraW 10398..11339 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849206 YP_001052724.1 CDS ftsL NC_009053.1 11352 11666 D cell division protein FtsL 11352..11666 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848698 YP_001052725.1 CDS ftsI NC_009053.1 11670 13730 D peptidoglycan synthetase FtsI 11670..13730 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849420 YP_001052726.1 CDS murE NC_009053.1 13754 15256 D involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate; UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase 13754..15256 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849091 YP_001052727.1 CDS murF NC_009053.1 15471 16865 D UDP-MurNAc-pentapeptide synthetase 15471..16865 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849439 YP_001052728.1 CDS mraY NC_009053.1 16962 18044 D First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; phospho-N-acetylmuramoyl-pentapeptide- transferase 16962..18044 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849765 YP_001052729.1 CDS murD NC_009053.1 18128 19438 D UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase 18128..19438 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849627 YP_001052730.1 CDS ftsW NC_009053.1 19440 20618 D cell division protein FtsW 19440..20618 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848662 YP_001052731.1 CDS murG NC_009053.1 20773 21828 D UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis; undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase 20773..21828 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849438 YP_001052732.1 CDS murC NC_009053.1 21880 23307 D Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis; UDP-N-acetylmuramate--L-alanine ligase 21880..23307 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849865 YP_001052733.1 CDS ddl NC_009053.1 23415 24326 D D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanine--D-alanine ligase 23415..24326 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849242 YP_001052734.1 CDS ftsQ NC_009053.1 24467 25120 D cell division protein FtsQ 24467..25120 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850111 YP_001052735.1 CDS ftsA NC_009053.1 25146 26420 D cell division protein FtsA 25146..26420 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850265 YP_001052736.1 CDS ftsZ NC_009053.1 26459 27670 D GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function; cell division protein FtsZ 26459..27670 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849860 YP_001052737.1 CDS lpxC NC_009053.1 27704 28624 D zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase 27704..28624 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848703 YP_001052738.1 CDS recN NC_009053.1 28786 30459 D DNA repair protein RecN 28786..30459 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850036 YP_001052739.1 CDS APL_0026 NC_009053.1 30601 32004 R ABC transporter ATP-binding protein complement(30601..32004) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849161 YP_001052740.1 CDS APL_0027 NC_009053.1 32004 32789 R nickel transport system permease complement(32004..32789) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850299 YP_001052741.1 CDS APL_0028 NC_009053.1 32792 33739 R ABC transporter permease complement(32792..33739) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849855 YP_001052742.1 CDS APL_0029 NC_009053.1 33833 35407 R ABC transporter periplasmic protein complement(33833..35407) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850375 YP_001052743.1 CDS prfC NC_009053.1 35601 37181 R stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein; peptide chain release factor 3 complement(35601..37181) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850473 YP_001052744.1 CDS APL_0031 NC_009053.1 37364 37831 D integral membrane protein 37364..37831 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848990 YP_001052745.1 CDS yhaH NC_009053.1 37878 38393 D hypothetical protein 37878..38393 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849641 YP_001052746.1 CDS pth NC_009053.1 38520 39104 D Enables the recycling of peptidyl-tRNAs produced at termination of translation; peptidyl-tRNA hydrolase 38520..39104 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850373 YP_001052747.1 CDS engD NC_009053.1 39213 40304 D translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1; GTP-dependent nucleic acid-binding protein EngD 39213..40304 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850367 YP_001052748.1 CDS APL_0035 NC_009053.1 40376 40813 D protein-S-isoprenylcysteine methyltransferase 40376..40813 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848852 YP_001052749.1 CDS APL_0036 NC_009053.1 40863 41138 R hypothetical protein complement(40863..41138) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849023 YP_001052750.1 CDS slyB NC_009053.1 41169 41633 R outer membrane lipoprotein complement(41169..41633) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849099 YP_001052751.1 CDS APL_0038 NC_009053.1 41660 42256 R hypothetical protein complement(41660..42256) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849455 YP_001052752.1 CDS argS NC_009053.1 42435 44081 D catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase; arginyl-tRNA synthetase 42435..44081 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849485 YP_001052753.1 CDS obgE NC_009053.1 44225 45400 D essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication; GTPase ObgE 44225..45400 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849935 YP_001052754.1 CDS APL_0041 NC_009053.1 45475 46086 D hypothetical protein 45475..46086 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850545 YP_001052755.1 CDS rlmB NC_009053.1 46186 46929 R Specifically methylates the ribose of guanosine 2251 in 23S rRNA; 23S rRNA (guanosine-2'-O-)-methyltransferase complement(46186..46929) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849275 YP_001052756.1 CDS pssA NC_009053.1 47008 48372 R catalyzes de novo synthesis of phosphatidylserine from CDP-diacylglycerol and L-serine which leads eventually to the production of phosphatidylethanolamine; bounds to the ribosome; phosphatidylserine synthase complement(47008..48372) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849573 YP_001052757.1 CDS ileS NC_009053.1 48524 51340 R IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 1 subfamily; some organisms carry two different copies of this enzyme; isoleucyl-tRNA synthetase complement(48524..51340) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849600 YP_001052758.1 CDS ribF NC_009053.1 51401 52363 R riboflavin biosynthesis protein complement(51401..52363) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849356 YP_001052759.1 CDS nadR NC_009053.1 52696 53976 D catalyzes the formation of NAD(+) from nicotinamide ribonucleotide; nicotinamide-nucleotide adenylyltransferase 52696..53976 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848774 YP_001052760.1 CDS APL_0047 NC_009053.1 53973 54671 D diadenosine tetraphosphatase 53973..54671 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848487 YP_001052761.1 CDS arcA NC_009053.1 54844 55560 D two-component response regulator 54844..55560 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850431 YP_001052762.1 CDS APL_0049 NC_009053.1 55612 56130 D hypothetical protein 55612..56130 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848466 YP_001052763.1 CDS APL_0050 NC_009053.1 56285 57073 R hypothetical protein complement(56285..57073) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848484 YP_001052764.1 CDS APL_0051 NC_009053.1 57311 57847 R 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase complement(57311..57847) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848509 YP_001052765.1 CDS APL_0052 NC_009053.1 57902 58597 D hypothetical protein 57902..58597 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849192 YP_001052766.1 CDS typA NC_009053.1 58930 60636 D GTP-binding protein 58930..60636 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850307 YP_001052767.1 CDS grxA NC_009053.1 60795 61058 D functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase; also involved in reducing some disulfides in a coupled system with glutathione reductase; glutaredoxin 60795..61058 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848965 YP_001052768.1 CDS rph NC_009053.1 61124 61840 R RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs; ribonuclease PH complement(61124..61840) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848506 YP_001052769.1 CDS yicC NC_009053.1 62044 62907 D hypothetical protein 62044..62907 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849267 YP_001052770.1 CDS APL_0057 NC_009053.1 62916 63803 D hypothetical protein 62916..63803 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848692 YP_001052771.1 CDS yfhL NC_009053.1 63853 64113 R ferredoxin complement(63853..64113) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849163 YP_001052772.1 CDS narP NC_009053.1 64259 64888 R nitrate/nitrite response regulator protein complement(64259..64888) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850420 YP_001052773.1 CDS rlmL NC_009053.1 65092 67230 D catalyzes the N2-methyl guanosine modification of the G2445 residue of 23S rRNA; 23S rRNA m(2)G2445 methyltransferase 65092..67230 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850334 YP_001052774.1 CDS yibK NC_009053.1 67288 67767 D tRNA/rRNA methyltransferase 67288..67767 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848512 YP_001052775.1 CDS mipB NC_009053.1 67907 68854 R transaldolase B complement(67907..68854) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848514 YP_001052776.1 CDS dppA NC_009053.1 75007 76602 D dipeptide transport protein 75007..76602 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849378 YP_001052777.1 CDS dppA NC_009053.1 76770 78371 D dipeptide transport protein 76770..78371 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849736 YP_001052778.1 CDS dppB NC_009053.1 78499 79503 D dipeptide transport system permease DppB 78499..79503 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849592 YP_001052779.1 CDS dppC NC_009053.1 79581 80471 D dipeptide transport system permease DppC 79581..80471 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849771 YP_001052780.1 CDS dppD NC_009053.1 80482 81468 D DppD and DppF are the ATP-binding components of the ABC dipeptide transport system DppABCDF; dipeptide transporter ATP-binding subunit 80482..81468 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850399 YP_001052781.1 CDS dppF NC_009053.1 81481 82470 D Part of the ABC transporter complex DppABCDF involved in the transport of dipeptides; dipeptide transporter ATP-binding subunit 81481..82470 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849111 YP_001052782.1 CDS psiE NC_009053.1 82543 82953 R phosphate-starvation-inducible protein PsiE complement(82543..82953) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848646 YP_001052783.1 CDS APL_0070 NC_009053.1 83031 83663 R hypothetical protein complement(83031..83663) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848660 YP_001052784.1 CDS APL_0071 NC_009053.1 83718 84062 R hypothetical protein complement(83718..84062) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848801 YP_001052785.1 CDS ilvE NC_009053.1 84149 85186 R catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; branched-chain amino acid aminotransferase complement(84149..85186) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850388 YP_001052786.1 CDS ydhD NC_009053.1 85329 85655 R monothiol glutaredoxin-like protein complement(85329..85655) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848705 YP_001052787.1 CDS recR NC_009053.1 85727 86392 R involved in a recombinational process of DNA repair, independent of the recBC complex; recombination protein RecR complement(85727..86392) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848935 YP_001052788.1 CDS ybaB NC_009053.1 86403 86732 R pubmed:14742511; hypothetical protein complement(86403..86732) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849372 YP_001052789.1 CDS tonB2 NC_009053.1 86901 87767 R pubmed:14742511; protein TonB2 complement(86901..87767) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849656 YP_001052790.1 CDS exbD2 NC_009053.1 87777 88166 R pubmed:14742511; biopolymer transport protein ExbD2 complement(87777..88166) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850227 YP_001052791.1 CDS exbB2 NC_009053.1 88211 88663 R pubmed:14742511; biopolymer transport protein ExbB2 complement(88211..88663) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849622 YP_001052792.1 CDS glpE NC_009053.1 88851 89177 D thiosulfate sulfurtransferase GlpE 88851..89177 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849423 YP_001052793.1 CDS APL_0080 NC_009053.1 89221 90066 D thioredoxin-like protein 89221..90066 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849473 YP_001052794.1 CDS dhaM NC_009053.1 90141 90548 R PTS system mannnose-specific transporter subunit IIA complement(90141..90548) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848860 YP_001052795.1 CDS dhaL NC_009053.1 90557 91183 R with DhaK and DhaM catalyzes the phosphorylation of dihydroxyacetone; dihydroxyacetone kinase subunit DhaL complement(90557..91183) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848917 YP_001052796.1 CDS dhaK NC_009053.1 91185 92255 R with DhaL and DhaM forms dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone; DhaK is the dihydroxyacetone binding subunit of the dihydroxyacetone kinase; dihydroxyacetone kinase subunit DhaK complement(91185..92255) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850016 YP_001052797.1 CDS trxB NC_009053.1 92425 93378 D thioredoxin reductase 92425..93378 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848878 YP_001052798.1 CDS kdsB NC_009053.1 93486 94238 D CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS; 3-deoxy-manno-octulosonate cytidylyltransferase 93486..94238 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850180 YP_001052799.1 CDS APL_0086 NC_009053.1 94362 94787 D hypothetical protein 94362..94787 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848829 YP_001052800.1 CDS nudC NC_009053.1 94861 95631 R can catalyze hydrolysis of broad range of dinucleotide pyrophosphates but prefers reduced form of NADH; requires divalent metal ions such as magnesium and manganese and produces two mononucleoside 5'-phosphates; NADH pyrophosphatase complement(94861..95631) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849752 YP_001052801.1 CDS rluE NC_009053.1 95649 96344 R ribosomal large subunit pseudouridine synthase E complement(95649..96344) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849869 YP_001052802.1 CDS rhaT NC_009053.1 96348 97166 R hypothetical protein complement(96348..97166) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850548 YP_001052803.1 CDS APL_0090 NC_009053.1 97196 97660 R hypothetical protein complement(97196..97660) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850415 YP_001052804.1 CDS pepQ NC_009053.1 97683 99014 R catalyzes the hydrolysis of dipeptides with a proline at the C-terminal; also catalyzes the low efficiency hydrolysis of organophosphate di- and tri-esters; proline dipeptidase complement(97683..99014) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850267 YP_001052805.1 CDS sirA NC_009053.1 99038 99277 D TusA; transfers sulfur to TusBCD complex; involved in thiouridation of U34 position of some tRNAs; sulfur transfer protein SirA 99038..99277 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850253 YP_001052806.1 CDS APL_0093 NC_009053.1 99327 99767 R hypothetical protein complement(99327..99767) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850458 YP_001052807.1 CDS engB NC_009053.1 99769 100389 R binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential; ribosome biogenesis GTP-binding protein YsxC complement(99769..100389) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850562 YP_001052808.1 CDS APL_0095 NC_009053.1 100684 101100 R hypothetical protein complement(100684..101100) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850025 YP_001052809.1 CDS APL_0096 NC_009053.1 101138 101968 R zinc transporter family protein ZIP complement(101138..101968) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849744 YP_001052810.1 CDS ilvD NC_009053.1 102119 103954 R catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; dihydroxy-acid dehydratase complement(102119..103954) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849997 YP_001052811.1 CDS ilvM NC_009053.1 104072 104290 R acetolactate synthase 2 regulatory subunit complement(104072..104290) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848715 YP_001052812.1 CDS ilvG NC_009053.1 104311 105810 R acetolactate synthase isozyme II large subunit complement(104311..105810) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848528 YP_001052813.1 CDS nrfA NC_009053.1 106390 107871 D catalyzes the formate-dependent reduction of nitrite to ammonia; cytochrome C552; cytochrome c552 106390..107871 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849298 YP_001052814.1 CDS nrfB NC_009053.1 107892 108539 D part of nitrite reductase complex; NrfB is active at high nitrate conditions; NrfA, B, C, and D are essential for the formate-dependent nitrite reduction to ammonia; cytochrome c nitrite reductase pentaheme subunit 107892..108539 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849077 YP_001052815.1 CDS nrfC NC_009053.1 108539 109216 D nitrate reductase 108539..109216 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849381 YP_001052816.1 CDS nrfD NC_009053.1 109216 110184 D nitrite reductase transmembrane protein 109216..110184 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849924 YP_001052817.1 CDS APL_0104 NC_009053.1 110472 119936 D autotransporter adhesin 110472..119936 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849579 YP_001052818.1 CDS uraA NC_009053.1 120177 121406 R uracil permease complement(120177..121406) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848529 YP_001052819.1 CDS putA NC_009053.1 121566 125171 R proline utilization protein A; multifunctional protein that functions in proline catabolism in the first two enzymatic steps resulting in the conversion of proline to glutamate; in Escherichia coli this protein self regulates transcription via a DNA-binding domain at the N-terminus but the protein from Pseudomonas does not have this domain; bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase complement(121566..125171) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850443 YP_001052820.1 CDS putP NC_009053.1 125274 126788 R sodium/proline symporter complement(125274..126788) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849239 YP_001052821.1 CDS iclR NC_009053.1 127363 128148 R HTH-type transcriptional regulator complement(127363..128148) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850533 YP_001052822.1 CDS APL_0109 NC_009053.1 128145 128720 R hypothetical protein complement(128145..128720) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849384 YP_001052823.1 CDS APL_0110 NC_009053.1 128991 129311 R hypothetical protein complement(128991..129311) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850432 YP_001052824.1 CDS APL_0111 NC_009053.1 129389 129940 D hypothetical protein 129389..129940 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848757 YP_001052825.1 CDS hemE NC_009053.1 130046 131110 D catalyzes the formation of coproporphyrinogen from uroporphyrinogen III; uroporphyrinogen decarboxylase 130046..131110 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849940 YP_001052826.1 CDS APL_0113 NC_009053.1 131234 131824 D hypothetical protein 131234..131824 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848468 YP_001052827.1 CDS hupA NC_009053.1 131960 132232 D DNA-binding protein HU 131960..132232 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850001 YP_001052828.1 CDS thyA NC_009053.1 132285 133136 R ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived; thymidylate synthase complement(132285..133136) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850429 YP_001052829.1 CDS APL_0116 NC_009053.1 133224 133808 D hypothetical protein 133224..133808 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848786 YP_001052830.1 CDS bioB NC_009053.1 133904 134914 D biotin synthase 133904..134914 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849847 YP_001052831.1 CDS cspC NC_009053.1 134978 135187 R cold shock-like protein CspC complement(134978..135187) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850298 YP_001052832.1 CDS proQ NC_009053.1 135550 136098 D affects solute and DNA transport through an unknown mechanism; solute/DNA competence effector 135550..136098 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848877 YP_001052833.1 CDS prc NC_009053.1 136190 138202 D Involved in the cleavage of a C-terminal peptide of 11 residues from the precursor form of penicillin-binding protein 3; carboxy-terminal protease 136190..138202 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849922 YP_001052834.1 CDS APL_0121 NC_009053.1 138299 139864 D hypothetical protein 138299..139864 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848724 YP_001052835.1 CDS APL_0122 NC_009053.1 140036 140590 D hypothetical protein 140036..140590 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849154 YP_001052836.1 CDS APL_0123 NC_009053.1 140608 141237 D glyoxalase II family protein 140608..141237 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850418 YP_001052837.1 CDS APL_0124 NC_009053.1 141240 141989 R hypothetical protein complement(141240..141989) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849767 YP_001052838.1 CDS APL_0125 NC_009053.1 141986 142360 R hypothetical protein complement(141986..142360) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850306 YP_001052839.1 CDS APL_0126 NC_009053.1 142362 142727 R HIT-like protein complement(142362..142727) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849657 YP_001052840.1 CDS yfeD NC_009053.1 142799 143629 R iron transport system membrane protein complement(142799..143629) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849141 YP_001052841.1 CDS yfeC NC_009053.1 143622 144476 R iron transport system membrane protein complement(143622..144476) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850468 YP_001052842.1 CDS rnhB NC_009053.1 144477 145070 R RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids; ribonuclease HII complement(144477..145070) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850382 YP_001052843.1 CDS engC NC_009053.1 145093 146127 R EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity; ribosome-associated GTPase complement(145093..146127) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848826 YP_001052844.1 CDS gcvA NC_009053.1 146637 147527 D Glycine cleavage system transcriptional activator; activates the gcvTHP operon in the presence of glycine and represses the operon in its absence; DNA-binding transcriptional activator GcvA 146637..147527 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848555 YP_001052845.1 CDS APL_0132 NC_009053.1 147527 148207 D manganese-dependent 5'-nucleotidase; specific for 5'-UMP, 5'-dUMP, and 5'-dTMP; member of haloacid dehalogenase (HAD)-like hydrolase superfamily; nucleotidase 147527..148207 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849778 YP_001052846.1 CDS cysB NC_009053.1 148207 149190 D LysR-type transcriptional regulator; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates cysteine biosynthesis by controlling expression of the cys regulon; autoregulates expression; crystal structure of Klebsiella aerogenes showed tetramer formation; transcriptional regulator CysB 148207..149190 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849948 YP_001052847.1 CDS APL_0134 NC_009053.1 149191 149835 D hypothetical protein 149191..149835 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848959 YP_001052848.1 CDS ansB NC_009053.1 149916 150965 R catalyzes the formation of aspartate from asparagine, periplasmic; regulated by cyclic AMP receptor protein (CRP) and also induced by anaerobiosis; L-asparaginase II complement(149916..150965) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849926 YP_001052849.1 CDS pyrG NC_009053.1 151269 152906 D CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer; CTP synthetase 151269..152906 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848586 YP_001052850.1 CDS APL_0137 NC_009053.1 153009 153515 D hypothetical protein 153009..153515 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849795 YP_001052851.1 CDS leuD NC_009053.1 153561 154163 R catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D; isopropylmalate isomerase small subunit complement(153561..154163) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849167 YP_001052852.1 CDS leuC NC_009053.1 154174 155583 R dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; isopropylmalate isomerase large subunit complement(154174..155583) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848700 YP_001052853.1 CDS APL_0140 NC_009053.1 155925 157040 D hypothetical protein 155925..157040 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849272 YP_001052854.1 CDS APL_0141 NC_009053.1 157168 158430 D hypothetical protein 157168..158430 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848973 YP_001052855.1 CDS glxK NC_009053.1 158441 159574 D glycerate kinase 158441..159574 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850276 YP_001052856.1 CDS APL_0143 NC_009053.1 159593 159865 D catalyzes the hydrolysis of acylphosphate; acylphosphatase 159593..159865 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849368 YP_001052857.1 CDS APL_0144 NC_009053.1 159936 161495 R ATP-dependent endonuclease complement(159936..161495) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849883 YP_001052858.1 CDS APL_0145 NC_009053.1 161499 162878 R hypothetical protein complement(161499..162878) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849240 YP_001052859.1 CDS dusA NC_009053.1 162938 163915 R tRNA-dihydrouridine synthase A complement(162938..163915) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848620 YP_001052860.1 CDS APL_0147 NC_009053.1 164268 165245 D ribonucleoside-diphosphate reductase subunit beta 164268..165245 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848713 YP_001052861.1 CDS rnr1 NC_009053.1 165232 166896 D Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 165232..166896 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849431 YP_001052862.1 CDS APL_0149 NC_009053.1 167032 167631 R cytoplasmic protein that may be involved in the utilization of double-stranded DNA as a carbon source; DNA uptake protein complement(167032..167631) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850137 YP_001052863.1 CDS nqrA NC_009053.1 168086 169435 D uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm; Na(+)-translocating NADH-quinone reductase subunit A 168086..169435 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848604 YP_001052864.1 CDS nqrB NC_009053.1 169440 170672 D uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm; Na(+)-translocating NADH-quinone reductase subunit B 169440..170672 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850490 YP_001052865.1 CDS nqrC NC_009053.1 170675 171448 D uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm; Na(+)-translocating NADH-quinone reductase subunit C 170675..171448 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850114 YP_001052866.1 CDS nqrD NC_009053.1 171448 172071 D Part of the NQR complex which catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm; Na(+)-translocating NADH-quinone reductase subunit D 171448..172071 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850337 YP_001052867.1 CDS nqrE NC_009053.1 172073 172669 D Part of the NQR complex which consists of NqrA, NqrB, NqrC, NqrD, NqrE and NqrF; NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm; NqrE is probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.; Na(+)-translocating NADH-quinone reductase subunit E 172073..172669 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848756 YP_001052868.1 CDS nqrF NC_009053.1 172680 173909 D uses the energy from reduction of ubiquinone-1 to ubiquinol to move Na(+) ions from the cytoplasm to the periplasm; Na(+)-translocating NADH-quinone reductase subunit F 172680..173909 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848745 YP_001052869.1 CDS apbE NC_009053.1 174116 175147 D thiamine biosynthesis lipoprotein ApbE 174116..175147 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849574 YP_001052870.1 CDS APL_0157 NC_009053.1 175160 175405 D hypothetical protein 175160..175405 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849639 YP_001052871.1 CDS mnmA NC_009053.1 175634 176803 D catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs; tRNA-specific 2-thiouridylase MnmA 175634..176803 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848961 YP_001052872.1 CDS hcaT NC_009053.1 176876 178030 R putative transporter of 3-phenylpropionate across the inner membrane; member of the major facilitator superfamily of transporters; 3-phenylpropionic acid transporter complement(176876..178030) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848879 YP_001052873.1 CDS proC NC_009053.1 178027 178857 R pyrroline-5-carboxylate reductase complement(178027..178857) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849218 YP_001052874.1 CDS rdgC NC_009053.1 179020 179928 D Required for efficient pilin antigenic variation; recombination associated protein 179020..179928 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850196 YP_001052875.1 CDS APL_0162 NC_009053.1 179938 180543 D phosphatase 179938..180543 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848789 YP_001052876.1 CDS APL_0163 NC_009053.1 180719 182578 R Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates; anaerobic ribonucleoside triphosphate reductase complement(180719..182578) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850074 YP_001052877.1 CDS APL_0164 NC_009053.1 182583 183050 R hypothetical protein complement(182583..183050) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848989 YP_001052878.1 CDS rnfA NC_009053.1 183432 184013 D Na(+)-translocating NADH-quinone reductase subunit E 183432..184013 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849320 YP_001052879.1 CDS rnfB NC_009053.1 184034 184624 D part of membrane-bound complex thought to be involved in electron transport to nitrogen; electron transport complex protein RnfB 184034..184624 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850292 YP_001052880.1 CDS rnfC NC_009053.1 184617 186929 D part of membrane-bound complex thought to be involved in electron transport to nitrogen; electron transport complex protein RnfC 184617..186929 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850091 YP_001052881.1 CDS APL_0168 NC_009053.1 186922 187566 D hypothetical protein 186922..187566 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849098 YP_001052882.1 CDS rnfD NC_009053.1 187586 188632 D RnfD; RsxD; required for nitrogen fixation in Rhodobacter capsulatus; part of a membrane-bound complex thought to be involved in electron transport to nitrogenase; in Escherichia coli this gene is part of a cluster controlling SoxR-mediated induction of the SoxS transcription factor in the absence of oxidizing agents; electron transport complex protein RnfD 187586..188632 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849268 YP_001052883.1 CDS rnfG NC_009053.1 188632 189264 D part of membrane-bound complex hought to be involved in electron transport to nitrogen; electron transport complex protein RnfG 188632..189264 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849174 YP_001052884.1 CDS rnfE NC_009053.1 189276 189962 D in Excherichia coli RsxABCDEG reduces SoxR which turns off induction of SoxS transcription factor in the absence of oxidizing agents; similar to the rnfABCDGE operon in Rhodobacter capsulatus involved in transferring electrons to nitrogenase; electron transport complex protein RsxE 189276..189962 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849181 YP_001052885.1 CDS msbB NC_009053.1 189971 190927 D Transfers myristate or laurate, activated on ACP, to the lipid IVA moiety of (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase 189971..190927 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849294 YP_001052886.1 CDS APL_0173 NC_009053.1 190987 191973 R hypothetical protein complement(190987..191973) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849297 YP_001052887.1 CDS tbpA NC_009053.1 192415 193380 D thiamine-binding periplasmic protein 192415..193380 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848929 YP_001052888.1 CDS dksA NC_009053.1 193587 194036 D DnaK suppressor protein 193587..194036 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848733 YP_001052889.1 CDS pcnB NC_009053.1 194179 195711 D poly(A) polymerase 194179..195711 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850168 YP_001052890.1 CDS folK NC_009053.1 195781 196251 D 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase 195781..196251 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849273 YP_001052891.1 CDS APL_0178 NC_009053.1 196289 196510 R hypothetical protein complement(196289..196510) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849590 YP_001052892.1 CDS APL_0179 NC_009053.1 196507 199203 R hypothetical protein complement(196507..199203) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849589 YP_001052893.1 CDS APL_0180 NC_009053.1 199236 200000 R hypothetical protein complement(199236..200000) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850195 YP_001052894.1 CDS gloA NC_009053.1 200154 200561 D lactoylglutathione lyase 200154..200561 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849951 YP_001052895.1 CDS dnaQ NC_009053.1 200701 201357 D Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A); ribonuclease T 200701..201357 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848650 YP_001052896.1 CDS APL_0183 NC_009053.1 201448 202725 R Mn2+/Fe2+ transporter complement(201448..202725) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849311 YP_001052897.1 CDS tyrA NC_009053.1 203301 204422 R catalyzes the formation of prephenate from chorismate and the formation of 4-hydroxyphenylpyruvate from prephenate in tyrosine biosynthesis; bifunctional chorismate mutase/prephenate dehydrogenase complement(203301..204422) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849979 YP_001052898.1 CDS aroF NC_009053.1 204535 205596 R catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, tyrosine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase complement(204535..205596) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848729 YP_001052899.1 CDS APL_0186 NC_009053.1 205638 206684 R ADP-heptose--LPS heptosyltransferase complement(205638..206684) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848721 YP_001052900.1 CDS pykA NC_009053.1 206772 208211 R pyruvate kinase complement(206772..208211) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849495 YP_001052901.1 CDS sixA NC_009053.1 208343 208834 D phosphohistidine phosphatase 208343..208834 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849543 YP_001052902.1 CDS dus NC_009053.1 209057 210019 D tRNA-dihydrouridine synthase B 209057..210019 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849811 YP_001052903.1 CDS fis NC_009053.1 210047 210343 D Stimulates excision of phage lambda; affects Mu development; acts as an activator of rRNA and iRNA transcription; DNA-binding protein Fis 210047..210343 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849061 YP_001052904.1 CDS APL_0191 NC_009053.1 210408 211766 R SNF family Na+-dependent transporter complement(210408..211766) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849377 YP_001052905.1 CDS dam NC_009053.1 211831 212664 R DNA adenine methylase complement(211831..212664) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850113 YP_001052906.1 CDS aroB NC_009053.1 212657 213757 R catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis; 3-dehydroquinate synthase complement(212657..213757) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849357 YP_001052907.1 CDS aroK NC_009053.1 213831 214352 R catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis; shikimate kinase complement(213831..214352) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849931 YP_001052908.1 CDS mrcA NC_009053.1 214614 217181 R membrane carboxypeptidase/penicillin-binding protein complement(214614..217181) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849608 YP_001052909.1 CDS APL_0196 NC_009053.1 217320 218000 D hypothetical protein 217320..218000 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849432 YP_001052910.1 CDS APL_0197 NC_009053.1 218072 218503 D hypothetical protein 218072..218503 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850377 YP_001052911.1 CDS APL_0198 NC_009053.1 218506 219033 D hypothetical protein 218506..219033 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850078 YP_001052912.1 CDS APL_0199 NC_009053.1 219026 219430 D hypothetical protein 219026..219430 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848727 YP_001052913.1 CDS hofQ NC_009053.1 219442 220740 D type II secretory pathway, component HofQ 219442..220740 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849326 YP_001052914.1 CDS nusB NC_009053.1 220866 221279 D Regulates rRNA biosynthesis by transcriptional antitermination; transcription antitermination protein NusB 220866..221279 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850347 YP_001052915.1 CDS thiL NC_009053.1 221347 222309 D thiamine-monophosphate kinase 221347..222309 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849002 YP_001052916.1 CDS pgpA NC_009053.1 222322 222795 D phosphatidylglycerophosphatase A 222322..222795 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849345 YP_001052917.1 CDS APL_0204 NC_009053.1 222804 223430 D threonine efflux protein 222804..223430 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849137 YP_001052918.1 CDS APL_0205 NC_009053.1 223489 224526 R rRNA methyltransferase complement(223489..224526) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848504 YP_001052919.1 CDS suhB NC_009053.1 224692 225504 D inositol-1-monophosphatase 224692..225504 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850361 YP_001052920.1 CDS dxs NC_009053.1 225625 227478 D catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate; 1-deoxy-D-xylulose-5-phosphate synthase 225625..227478 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849947 YP_001052921.1 CDS APL_0208 NC_009053.1 227524 227862 R transposase-like protein complement(227524..227862) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849697 YP_001052922.1 CDS APL_0209 NC_009053.1 227895 228212 R transposase-like protein complement(227895..228212) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849959 YP_001052923.1 CDS APL_0210 NC_009053.1 228224 228733 R transposase and inactivated derivatives complement(228224..228733) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848969 YP_001052924.1 CDS glyA NC_009053.1 228822 230087 R catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase complement(228822..230087) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849582 YP_001052925.1 CDS ppnK NC_009053.1 230318 231205 R catalyzes the phosphorylation of NAD to NADP; inorganic polyphosphate/ATP-NAD kinase complement(230318..231205) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848976 YP_001052926.1 CDS APL_0213 NC_009053.1 231296 234643 R hypothetical protein complement(231296..234643) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850321 YP_001052927.1 CDS APL_0214 NC_009053.1 234640 235596 R hypothetical protein complement(234640..235596) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850069 YP_001052928.1 CDS APL_0215 NC_009053.1 237305 237874 R hypothetical protein complement(237305..237874) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849803 YP_001052929.1 CDS APL_0216 NC_009053.1 237877 238872 R hypothetical protein complement(237877..238872) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848799 YP_001052930.1 CDS APL_0217 NC_009053.1 238874 239833 R hypothetical protein complement(238874..239833) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849603 YP_001052931.1 CDS APL_0218 NC_009053.1 239830 241179 R hypothetical protein complement(239830..241179) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849123 YP_001052932.1 CDS thrS NC_009053.1 241585 243516 D catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; threonyl-tRNA synthetase 241585..243516 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850216 YP_001052933.1 CDS APL_0220 NC_009053.1 243658 244332 D lipoprotein 243658..244332 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848459 YP_001052934.1 CDS APL_0221 NC_009053.1 244342 244689 D hypothetical protein 244342..244689 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849136 YP_001052935.1 CDS APL_0222 NC_009053.1 244701 245360 D lipoprotein 244701..245360 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848999 YP_001052936.1 CDS infC NC_009053.1 245638 246117 D translation initiation factor IF-3 245638..246117 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849300 YP_001052937.1 CDS rpmI NC_009053.1 246366 246563 D 50S ribosomal protein L35 246366..246563 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848747 YP_001052938.1 CDS rplT NC_009053.1 246631 246984 D binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit; 50S ribosomal protein L20 246631..246984 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849480 YP_001052939.1 CDS APL_0226 NC_009053.1 247033 247569 D hypothetical protein 247033..247569 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849692 YP_001052940.1 CDS APL_0227 NC_009053.1 247602 247895 D hypothetical protein 247602..247895 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849604 YP_001052941.1 CDS APL_0228 NC_009053.1 247952 249247 R hypothetical protein complement(247952..249247) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850052 YP_001052942.1 CDS rluA NC_009053.1 249291 249941 R RNA pseudouridine synthase complement(249291..249941) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848886 YP_001052943.1 CDS gpmB NC_009053.1 249991 250623 D phosphoglycerate mutase 249991..250623 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849578 YP_001052944.1 CDS APL_0231 NC_009053.1 250690 251103 R similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function; Holliday junction resolvase-like protein complement(250690..251103) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849687 YP_001052945.1 CDS APL_0232 NC_009053.1 251156 251716 R hypothetical protein complement(251156..251716) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849131 YP_001052946.1 CDS APL_0233 NC_009053.1 251716 252447 R in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase; 16S ribosomal RNA methyltransferase RsmE complement(251716..252447) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849410 YP_001052947.1 CDS APL_0234 NC_009053.1 252622 253212 R lipoprotein complement(252622..253212) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848763 YP_001052948.1 CDS bolA NC_009053.1 253341 253652 D stress-induced morphogen 253341..253652 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849709 YP_001052949.1 CDS APL_0236 NC_009053.1 254045 254419 R lipoprotein complement(254045..254419) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849291 YP_001052950.1 CDS APL_0237 NC_009053.1 254439 254747 R hypothetical protein complement(254439..254747) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849938 YP_001052951.1 CDS APL_0238 NC_009053.1 254850 255176 D hypothetical protein 254850..255176 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850328 YP_001052952.1 CDS secA NC_009053.1 255285 258002 D functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA 255285..258002 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849668 YP_001052953.1 CDS APL_0240 NC_009053.1 258132 259319 D hypothetical protein 258132..259319 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849575 YP_001052954.1 CDS mutT NC_009053.1 259316 259714 D mutator mutT protein 259316..259714 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849832 YP_001052955.1 CDS argC NC_009053.1 259949 260893 D catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis; N-acetyl-gamma-glutamyl-phosphate reductase 259949..260893 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849407 YP_001052956.1 CDS argB NC_009053.1 260923 261777 D catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate; acetylglutamate kinase 260923..261777 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850320 YP_001052957.1 CDS argD NC_009053.1 261791 262972 D catalyzes the formation of N-acetyl-l-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine; acetylornithine aminotransferase 261791..262972 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849016 YP_001052958.1 CDS APL_0245 NC_009053.1 263186 264895 D transferrin binding protein-like solute binding protein 263186..264895 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850352 YP_001052959.1 CDS APL_0246 NC_009053.1 264910 267177 D truncated transferrin-binding protein 1 264910..267177 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850331 YP_001052960.1 CDS rho NC_009053.1 267745 269007 R An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes; transcription termination factor Rho complement(267745..269007) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848841 YP_001052961.1 CDS cysK NC_009053.1 269205 270155 R cysteine synthase complement(269205..270155) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850357 YP_001052962.1 CDS thrB NC_009053.1 270367 271317 R catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate; homoserine kinase complement(270367..271317) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848981 YP_001052963.1 CDS thrA NC_009053.1 271317 273773 R multifunctional homotetrameric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways; bifunctional aspartokinase I/homoserine dehydrogenase I complement(271317..273773) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849975 YP_001052964.1 CDS sodA NC_009053.1 274183 274824 D manganese superoxide dismutase 274183..274824 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849691 YP_001052965.1 CDS alr NC_009053.1 274912 276036 R converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer; alanine racemase complement(274912..276036) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850055 YP_001052966.1 CDS recD NC_009053.1 276157 278094 D exodeoxyribonuclease V subunit alpha 276157..278094 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850327 YP_001052967.1 CDS pepD NC_009053.1 284242 285696 R aminoacyl-histidine dipeptidase complement(284242..285696) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849124 YP_001052968.1 CDS gpt NC_009053.1 285869 286342 D catalyzes the conversion of guanine, xanthine and, to a lesser extent, hypoxanthine to GMP, XMP and IMP, respectively; xanthine-guanine phosphoribosyltransferase 285869..286342 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848992 YP_001052969.1 CDS gmk NC_009053.1 286426 287046 D Essential for recycling GMP and indirectly, cGMP; guanylate kinase 286426..287046 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849492 YP_001052970.1 CDS APL_0257 NC_009053.1 287148 288542 D outer membrane protein 287148..288542 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850131 YP_001052971.1 CDS APL_0258 NC_009053.1 288590 288886 R hypothetical protein complement(288590..288886) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849411 YP_001052972.1 CDS APL_0259 NC_009053.1 288879 289313 R oligoketide cyclase/lipid transport protein complement(288879..289313) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849024 YP_001052973.1 CDS modC NC_009053.1 289361 290416 R Part of the ABC transporter complex modABC involved in molybdenum import; molybdate transporter ATP-binding protein complement(289361..290416) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850463 YP_001052974.1 CDS modB NC_009053.1 290420 291109 R part of ModCBA molybdate transporter; member of ABC superfamily; inner membrane component; regulated by repressor protein ModE; molybdate ABC transporter permease complement(290420..291109) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849595 YP_001052975.1 CDS modA NC_009053.1 291169 291927 R molybdate-binding periplasmic protein complement(291169..291927) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849834 YP_001052976.1 CDS APL_0263 NC_009053.1 292023 292784 R ABC transport system permease complement(292023..292784) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850204 YP_001052977.1 CDS APL_0264 NC_009053.1 292788 293696 R ABC transporter ATP-binding protein complement(292788..293696) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850520 YP_001052978.1 CDS dnaX NC_009053.1 293696 295762 R catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA; DNA polymerase III subunits gamma and tau complement(293696..295762) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848964 YP_001052979.1 CDS apt NC_009053.1 295811 296350 R catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis; adenine phosphoribosyltransferase complement(295811..296350) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850209 YP_001052980.1 CDS APL_0267 NC_009053.1 296551 297183 D hypothetical protein 296551..297183 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850194 YP_001052981.1 CDS APL_0268 NC_009053.1 297183 297545 D translation initiation inhibitor 297183..297545 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850339 YP_001052982.1 CDS thrCA NC_009053.1 297556 298650 D threonine synthase 297556..298650 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850358 YP_001052983.1 CDS APL_0270 NC_009053.1 298665 299156 D hypothetical protein 298665..299156 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849299 YP_001052984.1 CDS APL_0271 NC_009053.1 299267 300022 R chelated iron transport system ATP-binding protein complement(299267..300022) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849295 YP_001052985.1 CDS yfeA NC_009053.1 300024 300920 R iron (chelated) ABC transporter, periplasmic-binding protein complement(300024..300920) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849179 YP_001052986.1 CDS APL_0273 NC_009053.1 300987 301322 R dissimilatory sulfite reductase complement(300987..301322) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849128 YP_001052987.1 CDS APL_0274 NC_009053.1 301375 302040 R hypothetical protein complement(301375..302040) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849125 YP_001052988.1 CDS pgsA NC_009053.1 302222 302773 D phosphatidylglycerophosphate synthase 302222..302773 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849015 YP_001052989.1 CDS frpB NC_009053.1 302893 304863 D iron-regulated outer membrane protein B 302893..304863 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848963 YP_001052990.1 CDS uvrC NC_009053.1 305016 306848 D The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision; excinuclease ABC subunit C 305016..306848 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848769 YP_001052991.1 CDS APL_0278 NC_009053.1 306917 307669 D Mg-dependent deoxyribonuclease 306917..307669 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848836 YP_001052992.1 CDS rep NC_009053.1 307806 309824 R ATP-dependent DNA helicase complement(307806..309824) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848755 YP_001052993.1 CDS potA NC_009053.1 310158 311273 D functions together with PotBCD (A2BCD) in ATP-dependent polyamine transport; PotA is the membrane-associated ATPase; putrescine/spermidine ABC transporter ATPase 310158..311273 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849576 YP_001052994.1 CDS potB NC_009053.1 311260 312126 D can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotB is a membrane component; spermidine/putrescine ABC transporter membrane protein 311260..312126 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850013 YP_001052995.1 CDS potC NC_009053.1 312153 312893 D can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotC is a membrane component; spermidine/putrescine ABC transporter membrane protein 312153..312893 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849700 YP_001052996.1 CDS ruvA NC_009053.1 313035 313640 D plays an essential role in ATP-dependent branch migration of the Holliday junction; Holliday junction DNA helicase RuvA 313035..313640 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848753 YP_001052997.1 CDS ruvB NC_009053.1 313779 314663 D promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration; Holliday junction DNA helicase RuvB 313779..314663 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849172 YP_001052998.1 CDS ubiG NC_009053.1 314720 315424 R Involved in ubiquinone biosynthesis; 3-demethylubiquinone-9 3-methyltransferase complement(314720..315424) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850312 YP_001052999.1 CDS gyrA NC_009053.1 315604 318294 D DNA gyrase subunit A 315604..318294 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848939 YP_001053000.1 CDS APL_0289 NC_009053.1 319940 320260 D hypothetical protein 319940..320260 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850251 YP_001053001.1 CDS APL_0290 NC_009053.1 320427 321521 D Type I restriction enzyme EcoR124II specificity protein 320427..321521 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848545 YP_001053002.1 CDS APL_0293 NC_009053.1 322648 325785 D type I site-specific restriction-modification system, R (restriction) subunit 322648..325785 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848791 YP_001053003.1 CDS uupA NC_009053.1 325804 327747 D Uup; in Escherichia coli this cytoplasmic protein was shown to contain ATPase activity; mutations in this gene affect RecA-independent excision of transposons and affects Mu bacteriophage growth; ABC transporter ATPase 325804..327747 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849858 YP_001053004.1 CDS APL_0295 NC_009053.1 327747 328511 D hypothetical protein 327747..328511 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850368 YP_001053005.1 CDS APL_0296 NC_009053.1 328590 328922 R hypothetical protein complement(328590..328922) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849367 YP_001053006.1 CDS cydA NC_009053.1 329378 330928 D cytochrome oxidase subunit 1 329378..330928 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848902 YP_001053007.1 CDS cydB NC_009053.1 330942 332078 D cytochrome oxidase subunit 2 330942..332078 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849720 YP_001053008.1 CDS APL_0299 NC_009053.1 332646 333035 D hypothetical protein 332646..333035 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848531 YP_001053009.1 CDS tolQ NC_009053.1 333070 333750 D colicin transport protein TolQ 333070..333750 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849739 YP_001053010.1 CDS tolR NC_009053.1 333829 334269 D membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins; colicin uptake protein TolR 333829..334269 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849474 YP_001053011.1 CDS tolA NC_009053.1 334285 335580 D cell envelope integrity inner membrane protein TolA 334285..335580 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849712 YP_001053012.1 CDS tolB NC_009053.1 335598 336878 D forms dimers; may be involved in cell envelope integrity; interacts with outer membrane proteins and with the C-terminal domain of inner membrane protein TolA; translocation protein TolB 335598..336878 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848550 YP_001053013.1 CDS palA NC_009053.1 336904 337374 D pubmed:8763621; outer membrane protein PalA 336904..337374 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850080 YP_001053014.1 CDS APL_0305 NC_009053.1 337552 338358 D hypothetical protein 337552..338358 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849003 YP_001053015.1 CDS djlA NC_009053.1 338438 339298 D functions as a co-chaperone with DnaK; involved in regulation of colanic acid capsule; inner membrane protein; dimerized via transmembrane domain; J-like domain is cytoplasmic and can functionally substitute for DnaJ; stimulates synthesis of colanic acid mucoid capsule through the RcsB/C signal transduction system; Dna-J like membrane chaperone protein 338438..339298 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848489 YP_001053016.1 CDS dusC NC_009053.1 339383 340345 D tRNA-dihydrouridine synthase C 339383..340345 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850130 YP_001053017.1 CDS APL_0308 NC_009053.1 340397 341443 D hypothetical protein 340397..341443 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848500 YP_001053018.1 CDS yheS NC_009053.1 341631 343547 R ABC transporter ATP-binding protein YheS complement(341631..343547) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849762 YP_001053019.1 CDS moeA NC_009053.1 344138 345379 D molybdopterin biosynthesis protein MoeA 344138..345379 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849782 YP_001053020.1 CDS moeB NC_009053.1 345389 346135 D ATP-dependent adenylate transferase, transfers adenyl moiety to the MoeD subunit of molybdopterin synthase; molybdopterin biosynthesis protein MoeB 345389..346135 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849852 YP_001053021.1 CDS rumA NC_009053.1 346529 347857 R in Escherichia coli this enzyme catalyzes the SAM-dependent methylation of U1939 in the 23S ribomal RNA; binds an iron-sulfur cluster [4Fe-4S]; 23S rRNA 5-methyluridine methyltransferase complement(346529..347857) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849070 YP_001053022.1 CDS APL_0313 NC_009053.1 347915 349240 D dGTPase family type 2 subfamily; presumably hydrolyzes dGTP to deoxyguanosine and triphosphate; deoxyguanosinetriphosphate triphosphohydrolase-like protein 347915..349240 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848469 YP_001053023.1 CDS hepA NC_009053.1 349416 352325 D transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA; ATP-dependent helicase HepA 349416..352325 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850089 YP_001053024.1 CDS rluA NC_009053.1 352395 353108 D ribosomal large subunit pseudouridine synthase A 352395..353108 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849289 YP_001053025.1 CDS ampD NC_009053.1 353304 353852 R N-acetyl-anhydromuranmyl-L-alanine amidase complement(353304..353852) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850174 YP_001053026.1 CDS yhiR NC_009053.1 353973 354815 D hypothetical protein 353973..354815 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849998 YP_001053027.1 CDS pyrE NC_009053.1 354902 355543 D involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate; orotate phosphoribosyltransferase 354902..355543 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850389 YP_001053028.1 CDS APL_0319 NC_009053.1 355682 356770 D hypothetical protein 355682..356770 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848467 YP_001053029.1 CDS metC NC_009053.1 356847 358037 R catalyzes the formation of L-homocysteine from cystathionine; cystathionine beta-lyase complement(356847..358037) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849519 YP_001053030.1 CDS dsbB NC_009053.1 358114 358653 R disulfide oxidoreductase; integral membrane protein; required for perioplasmic disulfide bond formation; oxidizes DsbA protein; disulfide bond formation protein B complement(358114..358653) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849109 YP_001053031.1 CDS nhaB NC_009053.1 358750 360291 R involved in regulation of intracellular pH under alkaline conditions; sodium/proton antiporter complement(358750..360291) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849254 YP_001053032.1 CDS fadR NC_009053.1 360456 361184 D Multifunctional regulator of fatty acid metabolism; fatty acid metabolism regulator 360456..361184 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848492 YP_001053033.1 CDS phoH NC_009053.1 361193 362263 D PhoH-like protein 361193..362263 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849644 YP_001053034.1 CDS APL_0325 NC_009053.1 362302 363279 R hypothetical protein complement(362302..363279) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848486 YP_001053035.1 CDS prfB NC_009053.1 363351 364256 R peptide chain release factor 2 complement(363351..364256) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849157 YP_001053036.1 CDS selD NC_009053.1 364716 365633 D catalyzes the formation of selenophosphate from selenide and ATP; selenophosphate synthetase 364716..365633 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850157 YP_001053037.1 CDS mutT NC_009053.1 365638 366093 D MutT/NUDIX family NTP pyrophosphohydrolase 365638..366093 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850060 YP_001053038.1 CDS APL_0329 NC_009053.1 366103 367302 D 2-octaprenyl-6-methoxyphenol hydroxylase 366103..367302 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848498 YP_001053039.1 CDS APL_0330 NC_009053.1 367332 367808 R hypothetical protein complement(367332..367808) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850308 YP_001053040.1 CDS hlp NC_009053.1 367865 368542 R lipoprotein complement(367865..368542) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849654 YP_001053041.1 CDS hlpB NC_009053.1 368623 369102 R lipoprotein HlpB complement(368623..369102) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850413 YP_001053042.1 CDS visC NC_009053.1 369238 370383 R monooxygenase family protein complement(369238..370383) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850274 YP_001053043.1 CDS APL_0334 NC_009053.1 370507 371367 R hypothetical protein complement(370507..371367) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849666 YP_001053044.1 CDS ptsN NC_009053.1 371386 371898 R PTS system, nitrogen regulatory IIA-like protein complement(371386..371898) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849772 YP_001053045.1 CDS yhgB NC_009053.1 371948 372673 R ABC transporter ATP-binding protein complement(371948..372673) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849032 YP_001053046.1 CDS APL_0337 NC_009053.1 372683 373186 R hypothetical protein complement(372683..373186) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848608 YP_001053047.1 CDS APL_0338 NC_009053.1 373211 373807 R hypothetical protein complement(373211..373807) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848798 YP_001053048.1 CDS pepC NC_009053.1 373967 376606 R catalyzes the formation of oxaloacetate from phosphoenolpyruvate; phosphoenolpyruvate carboxylase complement(373967..376606) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848495 YP_001053049.1 CDS APL_0340 NC_009053.1 376821 377660 R hypothetical protein complement(376821..377660) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849749 YP_001053050.1 CDS APL_0341 NC_009053.1 377657 378106 R hypothetical protein complement(377657..378106) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848473 YP_001053051.1 CDS APL_0342 NC_009053.1 378173 378733 R hypothetical protein complement(378173..378733) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848493 YP_001053052.1 CDS fruA NC_009053.1 378909 380570 R Includes: Fructose-specific phosphotransferase enzyme IIB component; Fructose permease IIC component; PTS system fructose-specific transporter subunit IIBC complement(378909..380570) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848501 YP_001053053.1 CDS fruK NC_009053.1 380652 381599 R converts fructose-1-phosphate and ATP to fructose-1,6-bisphosphate and ADP; highly specific for fructose-1-phopshate; similar to PfkB; forms homodimers; 1-phosphofructokinase complement(380652..381599) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848472 YP_001053054.1 CDS fruB NC_009053.1 381614 383122 R phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIA is phosphorylated by phospho-HP which then transfers the phosphoryl group to the IIB componentr; PTS system fructose-specific transporter subunit IIA/HPr protein complement(381614..383122) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848474 YP_001053055.1 CDS glgB NC_009053.1 383383 385716 D catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain; glycogen branching protein 383383..385716 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849471 YP_001053056.1 CDS glgX NC_009053.1 385723 387708 D glycogen operon protein GlgX 385723..387708 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848505 YP_001053057.1 CDS glgC NC_009053.1 387724 389040 D catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate; glucose-1-phosphate adenylyltransferase 387724..389040 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848510 YP_001053058.1 CDS glgA NC_009053.1 389143 390579 D catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose; glycogen synthase 389143..390579 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849988 YP_001053059.1 CDS glgP NC_009053.1 390609 393113 D glycogen phosphorylase 390609..393113 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849041 YP_001053060.1 CDS ndk NC_009053.1 393225 393641 R nucleoside diphosphate kinase complement(393225..393641) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849819 YP_001053061.1 CDS metG NC_009053.1 393700 395727 R methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content; methionyl-tRNA synthetase complement(393700..395727) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849066 YP_001053062.1 CDS menC NC_009053.1 395906 396868 D catalyzes the dehydration of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid to form O-succinylbenzoate; O-succinylbenzoate synthase 395906..396868 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848940 YP_001053063.1 CDS rsuA NC_009053.1 397182 397874 D ribosomal small subunit pseudouridine synthase A 397182..397874 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850423 YP_001053064.1 CDS proP NC_009053.1 397874 399070 D Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance; bicyclomycin/multidrug efflux system protein 397874..399070 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850102 YP_001053065.1 CDS APL_0356 NC_009053.1 399116 399502 R hypothetical protein complement(399116..399502) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850145 YP_001053066.1 CDS APL_0357 NC_009053.1 399573 400142 R hypothetical protein complement(399573..400142) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848684 YP_001053067.1 CDS nfo NC_009053.1 400200 401042 D Assists in DNA repair by cleaving phosphodiester bonds at apurinic or apyrimidinic sties to produce new 5' ends that are base-free deoxyribose 5-phosphate residues; endonuclease IV 400200..401042 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849433 YP_001053068.1 CDS nlpC NC_009053.1 401163 401759 D lipoprotein 401163..401759 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849434 YP_001053069.1 CDS impA NC_009053.1 401808 402263 R hypothetical protein complement(401808..402263) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849776 YP_001053070.1 CDS grcA NC_009053.1 402489 402875 R stress-induced glycyl radical protein that can replace an oxidatively damaged pyruvate formate-lyase subunit; autonomous glycyl radical cofactor GrcA complement(402489..402875) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850301 YP_001053071.1 CDS ung NC_009053.1 403081 403758 D Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; uracil-DNA glycosylase 403081..403758 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848615 YP_001053072.1 CDS APL_0363 NC_009053.1 403856 404728 R hypothetical protein complement(403856..404728) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849435 YP_001053073.1 CDS ssa1 NC_009053.1 404823 407621 R serotype-specific antigen 1 complement(404823..407621) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848488 YP_001053074.1 CDS hrpA NC_009053.1 407842 411741 R involved in the post-transcriptional processing of the daa operon mRNA, which encodes proteins involved in fimbrial biogenesis of an enteropathogenic E. coli strain; ATP-dependent RNA helicase HrpA complement(407842..411741) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848496 YP_001053075.1 CDS APL_0366 NC_009053.1 411911 412363 R hypothetical protein complement(411911..412363) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849063 YP_001053076.1 CDS grpE NC_009053.1 412560 413156 R with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor; heat shock protein GrpE complement(412560..413156) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849732 YP_001053077.1 CDS potD2 NC_009053.1 413401 414483 D spermidine/putrescine-binding periplasmic protein 1 413401..414483 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849538 YP_001053078.1 CDS norM NC_009053.1 414627 416018 D multidrug resistance protein NorM 414627..416018 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849637 YP_001053079.1 CDS recB NC_009053.1 416034 419642 D exodeoxyribonuclease V subunit beta 416034..419642 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848610 YP_001053080.1 CDS lnt NC_009053.1 419720 421231 R Transfers the fatty acyl group on membrane lipoproteins; apolipoprotein N-acyltransferase complement(419720..421231) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848490 YP_001053081.1 CDS corC NC_009053.1 421313 422206 R magnesium and cobalt efflux protein complement(421313..422206) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849211 YP_001053082.1 CDS APL_0373 NC_009053.1 422376 422978 D hypothetical protein 422376..422978 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849734 YP_001053083.1 CDS glpF NC_009053.1 423214 423996 D glycerol uptake facilitator protein 423214..423996 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849747 YP_001053084.1 CDS glpK NC_009053.1 424031 425542 D Converts glycerol and ADP to glycerol-3-phosphate and ADP; glycerol kinase 424031..425542 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850540 YP_001053085.1 CDS lon NC_009053.1 425663 428071 R ATP-dependent protease La complement(425663..428071) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849930 YP_001053086.1 CDS glpT NC_009053.1 428217 429662 R glycerol-3-phosphate transporter complement(428217..429662) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849214 YP_001053087.1 CDS glpQ NC_009053.1 429865 430953 R hydrolyzes deacylated phospholipids to glycerol 3-phosphate and the corresponding alcohols; periplasmic; glycerophosphodiester phosphodiesterase complement(429865..430953) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849296 YP_001053088.1 CDS glpA NC_009053.1 431205 432890 D anaerobic, catalyzes the conversion of glycerol 3-phosphate to dihydroxyacetone using fumarate or nitrate as electron acceptor; sn-glycerol-3-phosphate dehydrogenase subunit A 431205..432890 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848491 YP_001053089.1 CDS glpB NC_009053.1 432880 434166 D sn-glycerol-3-phosphate dehydrogenase (anaerobic); catalyzes the formation of dihydroxyacetone from glycerol 3-phosphate; part of GlpABC complex; presumably this subunit is responsible for membrane interactions and contains iron-sulfur clusters; anaerobic glycerol-3-phosphate dehydrogenase subunit B 432880..434166 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849845 YP_001053090.1 CDS glpC NC_009053.1 434163 435437 D anaerobic; with GlpAB catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate; sn-glycerol-3-phosphate dehydrogenase subunit C 434163..435437 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849497 YP_001053091.1 CDS ribD NC_009053.1 435609 436841 D pubmed:8522537; Includes: Diaminohydroxyphosphoribosylaminopyrimidine deaminase; 5-amino-6-(5-phosphoribosylamino)uracil reductase; riboflavin biosynthesis protein 435609..436841 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850371 YP_001053092.1 CDS ribE NC_009053.1 436964 437611 D catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine; riboflavin synthase subunit alpha 436964..437611 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850289 YP_001053093.1 CDS ribA NC_009053.1 437672 438877 D pubmed:8522537; Includes: GTP cyclohydrolase-2; 3,4-dihydroxy-2-butanone 4-phosphate synthase; riboflavin biosynthesis protein 437672..438877 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850491 YP_001053094.1 CDS ribH NC_009053.1 438988 439449 D RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not; 6,7-dimethyl-8-ribityllumazine synthase 438988..439449 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850446 YP_001053095.1 CDS greB NC_009053.1 439538 440026 R necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreB complement(439538..440026) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849984 YP_001053096.1 CDS kpsF NC_009053.1 440036 440971 R arabinose-5-phosphate isomerase complement(440036..440971) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848889 YP_001053097.1 CDS pepB NC_009053.1 441099 442391 R catalyzes the removal of an N-terminal amino acid from a peptide or arylamide; aminopeptidase B complement(441099..442391) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849640 YP_001053098.1 CDS ompP4 NC_009053.1 442506 443321 R lipoprotein E complement(442506..443321) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849773 YP_001053099.1 CDS APL_0390 NC_009053.1 443494 444432 D hypothetical protein 443494..444432 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850084 YP_001053100.1 CDS macA NC_009053.1 444512 445693 R macrolide-specific efflux protein complement(444512..445693) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849198 YP_001053101.1 CDS APL_0392 NC_009053.1 445790 446605 R hypothetical protein complement(445790..446605) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848966 YP_001053102.1 CDS leuA NC_009053.1 447202 448743 D catalyzes the formation of 2-isopropylmalate from acetyl-CoA and 2-oxoisovalerate in leucine biosynthesis; 2-isopropylmalate synthase 447202..448743 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848680 YP_001053103.1 CDS rpoE NC_009053.1 449086 449664 D Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response; RNA polymerase sigma factor RpoE 449086..449664 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850464 YP_001053104.1 CDS rseA NC_009053.1 449684 450307 D sigma-E factor negative regulatory protein 449684..450307 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849993 YP_001053105.1 CDS rseC NC_009053.1 450532 450960 D sigma-E factor regulatory protein 450532..450960 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848823 YP_001053106.1 CDS lcfA NC_009053.1 450972 452663 D Activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase 450972..452663 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849270 YP_001053107.1 CDS upp NC_009053.1 452730 453356 D Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate; uracil phosphoribosyltransferase 452730..453356 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850045 YP_001053108.1 CDS ksgA NC_009053.1 453463 454332 R catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin; dimethyladenosine transferase complement(453463..454332) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850436 YP_001053109.1 CDS surA NC_009053.1 454398 455348 R peptidyl-prolyl cis-trans isomerase SurA complement(454398..455348) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848708 YP_001053110.1 CDS pyrR NC_009053.1 455429 455968 R regulates pyrimidine biosynthesis by binding to the mRNA of the pyr genes, also has been shown to have uracil phosphoribosyltransferase activity; bifunctional pyrimidine regulatory protein PyrR/uracil phosphoribosyltransferase complement(455429..455968) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849058 YP_001053111.1 CDS hldE NC_009053.1 455984 457414 R catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate to form D,D-heptose-1,7-bisphosphate and catalyzes transfer of ADP to D-glycero-D-manno-heptose 1-phosphate forming ADP-D,D-heptose; bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase complement(455984..457414) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849548 YP_001053112.1 CDS engA NC_009053.1 457528 459048 R EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains; GTP-binding protein EngA complement(457528..459048) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850385 YP_001053113.1 CDS hemA NC_009053.1 459206 460516 R catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins; glutamyl-tRNA reductase complement(459206..460516) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849853 YP_001053114.1 CDS relA NC_009053.1 460794 463001 D GTP pyrophosphokinase 460794..463001 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850472 YP_001053115.1 CDS dxr NC_009053.1 463075 464265 D catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate; 1-deoxy-D-xylulose 5-phosphate reductoisomerase 463075..464265 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850032 YP_001053116.1 CDS lpxA NC_009053.1 464325 465119 R catalyzes the addition of (R)-3-hydroxytetradecanoyl to the glucosamine disaccharide in lipid A biosynthesis; UDP-N-acetylglucosamine acyltransferase complement(464325..465119) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850034 YP_001053117.1 CDS fabZ NC_009053.1 465147 465611 R in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP; (3R)-hydroxymyristoyl-ACP dehydratase complement(465147..465611) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850532 YP_001053118.1 CDS lpxD NC_009053.1 465680 466705 R adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase complement(465680..466705) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850126 YP_001053119.1 CDS APL_0410 NC_009053.1 466705 467511 R hypothetical protein complement(466705..467511) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850156 YP_001053120.1 CDS D15 NC_009053.1 467627 470008 R protective surface antigen D15 complement(467627..470008) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849236 YP_001053121.1 CDS ecfE NC_009053.1 470070 471383 R zinc metalloprotease complement(470070..471383) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849151 YP_001053122.1 CDS cdsA NC_009053.1 471390 472259 R phosphatidate cytidylyltransferase complement(471390..472259) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849555 YP_001053123.1 CDS uppS NC_009053.1 472284 472997 R undecaprenyl pyrophosphate synthetase complement(472284..472997) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850397 YP_001053124.1 CDS gloB NC_009053.1 473169 473876 R hydroxyacylglutathione hydrolase complement(473169..473876) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848668 YP_001053125.1 CDS APL_0416 NC_009053.1 473935 474852 R catalyzes the formation of N-acetyl-D-glucosamine-6-phosphate from N-acetyl-D-glucosamine; N-acetyl-D-glucosamine kinase complement(473935..474852) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850273 YP_001053126.1 CDS pgpB NC_009053.1 474855 475559 R phosphatidylglycerophosphatase B complement(474855..475559) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849227 YP_001053127.1 CDS APL_0418 NC_009053.1 475651 476052 R hypothetical protein complement(475651..476052) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848847 YP_001053128.1 CDS lgtF NC_009053.1 476090 476848 D UDP-glucose--lipooligosaccharide glucosyltransferase 476090..476848 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848858 YP_001053129.1 CDS pbpG NC_009053.1 476952 477731 R penicillin-binding protein 7 complement(476952..477731) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850322 YP_001053130.1 CDS waaQ NC_009053.1 477815 478852 R heptosyltransferase complement(477815..478852) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849880 YP_001053131.1 CDS argG NC_009053.1 479096 480427 D catalyzes the formation of arginosuccinate from citrulline and aspartate in arginine biosynthesis; argininosuccinate synthase 479096..480427 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849166 YP_001053132.1 CDS rnhA NC_009053.1 480549 481010 D An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids; ribonuclease H 480549..481010 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849462 YP_001053133.1 CDS cvpA NC_009053.1 481167 481670 D colicin V production protein 481167..481670 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850387 YP_001053134.1 CDS purF NC_009053.1 481684 483201 D Catalyzes first step of the de novo purine nucleotide biosynthetic pathway; amidophosphoribosyltransferase 481684..483201 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849646 YP_001053135.1 CDS APL_0426 NC_009053.1 483270 483728 R hypothetical protein complement(483270..483728) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849512 YP_001053136.1 CDS gdhA NC_009053.1 483824 485164 R converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer; glutamate dehydrogenase complement(483824..485164) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849507 YP_001053137.1 CDS smpA NC_009053.1 485468 485812 R small protein A complement(485468..485812) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849093 YP_001053138.1 CDS APL_0429 NC_009053.1 485883 486884 R nucleoid-associated protein NdpA complement(485883..486884) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849616 YP_001053139.1 CDS APL_0430 NC_009053.1 486977 487366 D hypothetical protein 486977..487366 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850275 YP_001053140.1 CDS APL_0431 NC_009053.1 487394 488131 D hypothetical protein 487394..488131 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848943 YP_001053141.1 CDS leuB NC_009053.1 488696 489778 D catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis; 3-isopropylmalate dehydrogenase 488696..489778 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849836 YP_001053142.1 CDS msrB NC_009053.1 489902 490297 R this stereospecific enzymes reduces the R isomer of methionine sulfoxide while MsrA reduces the S form; provides protection against oxidative stress; methionine sulfoxide reductase B complement(489902..490297) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850240 YP_001053143.1 CDS gapA NC_009053.1 490520 491524 D glyceraldehyde-3-phosphate dehydrogenase 490520..491524 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849090 YP_001053144.1 CDS mreB NC_009053.1 491720 492772 D functions in MreBCD complex in some organisms; rod shape-determining protein MreB 491720..492772 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849029 YP_001053145.1 CDS mreC NC_009053.1 492889 493938 D in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall; rod shape-determining protein MreC 492889..493938 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849620 YP_001053146.1 CDS mreD NC_009053.1 493938 494426 D rod shape-determining protein MreD 493938..494426 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850011 YP_001053147.1 CDS APL_0438 NC_009053.1 494439 495779 D recombination factor protein RarA 494439..495779 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849421 YP_001053148.1 CDS znuB NC_009053.1 495860 496645 D high-affinity zinc uptake system membrane protein ZnuB 495860..496645 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850129 YP_001053149.1 CDS APL_0440 NC_009053.1 496824 497621 D hypothetical protein 496824..497621 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848890 YP_001053150.1 CDS metX NC_009053.1 497701 498777 R Catalyzes the conversion of acetyl-CoA and L-homoserine to CoA and O-acetyl-L-homoserine; homoserine O-acetyltransferase complement(497701..498777) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848898 YP_001053151.1 CDS sanA NC_009053.1 499069 499758 D SanA protein 499069..499758 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848750 YP_001053152.1 CDS APL_0443 NC_009053.1 500018 510061 D autotransporter adhesin 500018..510061 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850478 YP_001053153.1 CDS APL_0444 NC_009053.1 510370 511068 R hypothetical protein complement(510370..511068) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849113 YP_001053154.1 CDS ykgF NC_009053.1 511197 512606 R electron transport protein complement(511197..512606) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849659 YP_001053155.1 CDS ykgE NC_009053.1 512616 513341 R dehydrogenase complement(512616..513341) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849509 YP_001053156.1 CDS lctP NC_009053.1 513511 515106 R L-lactate permease complement(513511..515106) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848664 YP_001053157.1 CDS hns NC_009053.1 515572 515979 R DNA-binding protein H-NS complement(515572..515979) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848588 YP_001053158.1 CDS APL_0449 NC_009053.1 516537 518054 D hypothetical protein 516537..518054 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850164 YP_001053159.1 CDS mglB NC_009053.1 518260 519231 D D-galactose-binding periplasmic protein 518260..519231 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849395 YP_001053160.1 CDS sucD NC_009053.1 519366 520238 R succinyl-CoA ligase [ADP-forming] subunit alpha complement(519366..520238) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849399 YP_001053161.1 CDS sucC NC_009053.1 520241 521407 R catalyzes the interconversion of succinyl-CoA and succinate; succinyl-CoA synthetase subunit beta complement(520241..521407) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850531 YP_001053162.1 CDS APL_0453 NC_009053.1 521551 522417 R hypothetical protein complement(521551..522417) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850456 YP_001053163.1 CDS sucB NC_009053.1 522560 523789 R dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex (E2) complement(522560..523789) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850079 YP_001053164.1 CDS sucA NC_009053.1 523909 526719 R SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide; 2-oxoglutarate dehydrogenase E1 component complement(523909..526719) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849779 YP_001053165.1 CDS znuC NC_009053.1 526962 527762 R high-affinity zinc uptake system ATP-binding protein ZnuC complement(526962..527762) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849945 YP_001053166.1 CDS APL_0457 NC_009053.1 527966 529456 D metalloprotease 527966..529456 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848513 YP_001053167.1 CDS dsbC NC_009053.1 529475 530170 D thiol:disulfide interchange protein DsbC 529475..530170 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849817 YP_001053168.1 CDS recJ NC_009053.1 530220 531977 D single-stranded-DNA-specific exonuclease RecJ 530220..531977 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848602 YP_001053169.1 CDS plpD NC_009053.1 532111 532962 D lipoprotein Plp4 532111..532962 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850167 YP_001053170.1 CDS APL_0461 NC_009053.1 533044 533862 D HAD superfamily hydrolase 533044..533862 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849088 YP_001053171.1 CDS narQ NC_009053.1 533862 535577 D nitrate/nitrite sensor protein NarQ 533862..535577 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848480 YP_001053172.1 CDS APL_0463 NC_009053.1 535600 536118 D sortase 535600..536118 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849369 YP_001053173.1 CDS APL_0464 NC_009053.1 536159 536755 D HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine; deoxyribonucleotide triphosphate pyrophosphatase 536159..536755 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849729 YP_001053174.1 CDS APL_0465 NC_009053.1 536783 537103 D hypothetical protein 536783..537103 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848645 YP_001053175.1 CDS fhs NC_009053.1 537209 538879 R catalyzes the formation of 10-formyltetrahydrofolate from formate and tetrahydrofolate; formate--tetrahydrofolate ligase complement(537209..538879) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850530 YP_001053176.1 CDS APL_0467 NC_009053.1 538989 539435 D hypothetical protein 538989..539435 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848516 YP_001053177.1 CDS APL_0468 NC_009053.1 539525 540274 D NADP-dependent dehydrogenase 539525..540274 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850519 YP_001053178.1 CDS trpB NC_009053.1 540457 541647 D catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate; tryptophan synthase subunit beta 540457..541647 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849352 YP_001053179.1 CDS trpA NC_009053.1 541649 542458 D catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis; tryptophan synthase subunit alpha 541649..542458 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849907 YP_001053180.1 CDS APL_0471 NC_009053.1 542535 542828 R hypothetical protein complement(542535..542828) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849380 YP_001053181.1 CDS APL_0472 NC_009053.1 542837 543121 R hypothetical protein complement(542837..543121) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849257 YP_001053182.1 CDS polA NC_009053.1 543301 546174 D has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair; DNA polymerase I 543301..546174 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849768 YP_001053183.1 CDS lolA NC_009053.1 546848 547489 D participates with LolB in the incorporation of lipoprotein into the outer membrane; outer-membrane lipoprotein carrier protein 546848..547489 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849737 YP_001053184.1 CDS trpR NC_009053.1 547564 547872 D When complexed with L-tryptophan it binds the operator region of the trp operon and prevents the initiation of transcription; Trp operon repressor 547564..547872 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850243 YP_001053185.1 CDS mtgA NC_009053.1 547901 548662 D monofunctional biosynthetic peptidoglycan transglycosylase 547901..548662 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849614 YP_001053186.1 CDS APL_0477 NC_009053.1 548732 549067 R hypothetical protein complement(548732..549067) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848694 YP_001053187.1 CDS APL_0478 NC_009053.1 549094 550098 R hypothetical protein complement(549094..550098) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850017 YP_001053188.1 CDS APL_0479 NC_009053.1 550113 550454 R hypothetical protein complement(550113..550454) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850042 YP_001053189.1 CDS APL_0480 NC_009053.1 550465 551808 R hypothetical protein complement(550465..551808) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850406 YP_001053190.1 CDS APL_0481 NC_009053.1 551853 552065 R hypothetical protein complement(551853..552065) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848914 YP_001053191.1 CDS APL_0482 NC_009053.1 552220 552507 D transcriptional regulator 552220..552507 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848732 YP_001053192.1 CDS APL_0483 NC_009053.1 552582 553301 D NADPH-dependent; oxygen-insensitive; catalyzes the reduction of nitroaromatic compounds; nitroreductase A 552582..553301 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849379 YP_001053193.1 CDS rimK NC_009053.1 553298 554212 D ribosomal protein S6 modification protein 553298..554212 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849742 YP_001053194.1 CDS APL_0485 NC_009053.1 554247 555005 R hypothetical protein complement(554247..555005) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848515 YP_001053195.1 CDS maeB NC_009053.1 555322 556590 D NADP-dependent malic enzyme (NADP-ME) 555322..556590 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849821 YP_001053196.1 CDS rplY NC_009053.1 556776 557063 D the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response; 50S ribosomal protein L25 556776..557063 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848481 YP_001053197.1 CDS APL_0488 NC_009053.1 557223 558263 R phage integrase family protein complement(557223..558263) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849290 YP_001053198.1 CDS APL_0489 NC_009053.1 558525 559046 R hypothetical protein complement(558525..559046) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849496 YP_001053199.1 CDS APL_0490 NC_009053.1 559253 559663 R hypothetical protein complement(559253..559663) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849941 YP_001053200.1 CDS APL_0491 NC_009053.1 559664 559897 R hypothetical protein complement(559664..559897) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849792 YP_001053201.1 CDS APL_0492 NC_009053.1 560157 560363 R hypothetical protein complement(560157..560363) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849944 YP_001053202.1 CDS APL_0493 NC_009053.1 560398 561120 R hypothetical protein complement(560398..561120) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849274 YP_001053203.1 CDS rdgC NC_009053.1 561319 562221 R Required for efficient pilin antigenic variation; recombination associated protein complement(561319..562221) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849138 YP_001053204.1 CDS APL_0495 NC_009053.1 565375 566190 R DNA-methyltransferase complement(565375..566190) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848485 YP_001053205.1 CDS APL_0496 NC_009053.1 566235 567878 R hypothetical protein complement(566235..567878) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849340 YP_001053206.1 CDS APL_0497 NC_009053.1 567934 568200 R hypothetical protein complement(567934..568200) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849731 YP_001053207.1 CDS APL_0498 NC_009053.1 568720 568908 D hypothetical protein 568720..568908 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849339 YP_001053208.1 CDS APL_0499 NC_009053.1 568967 569662 D hypothetical protein 568967..569662 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850383 YP_001053209.1 CDS APL_0500 NC_009053.1 569818 570690 D hypothetical protein 569818..570690 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849387 YP_001053210.1 CDS APL_0501 NC_009053.1 570693 571217 D DNA methylase 570693..571217 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849217 YP_001053211.1 CDS APL_0502 NC_009053.1 571412 572434 D hypothetical protein 571412..572434 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849972 YP_001053212.1 CDS rusA NC_009053.1 572506 572874 D endodeoxyribonuclease RusA 572506..572874 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850208 YP_001053213.1 CDS APL_0504 NC_009053.1 572867 573379 D hypothetical protein 572867..573379 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849116 YP_001053214.1 CDS APL_0505 NC_009053.1 573751 574293 D endolysin 573751..574293 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850222 YP_001053215.1 CDS APL_0506 NC_009053.1 574385 574756 D hypothetical protein 574385..574756 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849479 YP_001053216.1 CDS APL_0507 NC_009053.1 575285 575704 D hypothetical protein 575285..575704 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849243 YP_001053217.1 CDS APL_0508 NC_009053.1 575707 577824 D bacteriophage tail assembly protein 575707..577824 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849735 YP_001053218.1 CDS APL_0509 NC_009053.1 578045 579565 D bacteriophage capsid protein 578045..579565 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849460 YP_001053219.1 CDS APL_0510 NC_009053.1 579501 581525 D Clp-like protease 579501..581525 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849362 YP_001053220.1 CDS APL_0511 NC_009053.1 581599 581922 D hypothetical protein 581599..581922 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849117 YP_001053221.1 CDS APL_0512 NC_009053.1 581915 582217 D hypothetical protein 581915..582217 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849284 YP_001053222.1 CDS APL_0513 NC_009053.1 582220 582747 D phage tail component 582220..582747 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849831 YP_001053223.1 CDS APL_0514 NC_009053.1 582744 583157 D hypothetical protein 582744..583157 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848507 YP_001053224.1 CDS APL_0515 NC_009053.1 583157 583813 D hypothetical protein 583157..583813 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849332 YP_001053225.1 CDS APL_0516 NC_009053.1 583872 584264 D hypothetical protein 583872..584264 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850236 YP_001053226.1 CDS APL_0517 NC_009053.1 584288 584563 D hypothetical protein 584288..584563 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850181 YP_001053227.1 CDS APL_0518 NC_009053.1 584929 588360 D hypothetical protein 584929..588360 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850425 YP_001053228.1 CDS APL_0519 NC_009053.1 588612 588947 D phage minor tail protein 588612..588947 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848522 YP_001053229.1 CDS APL_0520 NC_009053.1 589800 590663 D hypothetical protein 589800..590663 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850026 YP_001053230.1 CDS APL_0521 NC_009053.1 590784 591521 D phage-related minor tail protein L 590784..591521 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849482 YP_001053231.1 CDS APL_0522 NC_009053.1 591682 592296 D phage-related tail assembly protein K 591682..592296 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849142 YP_001053232.1 CDS APL_0523 NC_009053.1 592320 592841 D phage tail assembly protein 592320..592841 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848502 YP_001053233.1 CDS APL_0524 NC_009053.1 593159 598756 D phage tail protein 593159..598756 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848476 YP_001053234.1 CDS APL_0525 NC_009053.1 598815 599156 D hypothetical protein 598815..599156 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848508 YP_001053235.1 CDS APL_0526 NC_009053.1 600117 600758 D hypothetical protein 600117..600758 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849960 YP_001053236.1 CDS APL_0527 NC_009053.1 600881 601744 D ABC transporter permease 600881..601744 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848511 YP_001053237.1 CDS APL_0528 NC_009053.1 601844 603292 D transporter 601844..603292 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849155 YP_001053238.1 CDS APL_0531 NC_009053.1 604407 605156 D ABC transporter permease 604407..605156 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850223 YP_001053239.1 CDS APL_0532 NC_009053.1 605200 605481 D molybdopterin/thiamine biosynthesis dinucleotide-utilizing protein 605200..605481 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849839 YP_001053240.1 CDS thiF NC_009053.1 605569 605949 D molybdopterin/thiamine biosynthesis dinucleotide-utilizing protein 605569..605949 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848599 YP_001053241.1 CDS thiS NC_009053.1 605980 606180 D thiamine biosynthesis protein ThiS 605980..606180 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850128 YP_001053242.1 CDS thiG NC_009053.1 606616 607026 D thiazole biosynthesis protein ThiG 606616..607026 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850160 YP_001053243.1 CDS thiH NC_009053.1 607036 608181 D thiazole biosynthesis protein ThiH 607036..608181 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848553 YP_001053244.1 CDS APL_0537 NC_009053.1 608236 608859 D transcriptional activator 608236..608859 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848854 YP_001053245.1 CDS APL_0538 NC_009053.1 608882 609826 D ABC transporter substrate-binding protein 608882..609826 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848853 YP_001053246.1 CDS thiD NC_009053.1 609992 610450 D phosphomethylpyrimidine kinase 609992..610450 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849500 YP_001053247.1 CDS thiE NC_009053.1 610464 610877 D thiamine monophosphate synthase 610464..610877 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849688 YP_001053248.1 CDS lepA NC_009053.1 611049 612848 D binds to the ribosome on the universally-conserved alpha-sarcin loop; GTP-binding protein LepA 611049..612848 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849995 YP_001053249.1 CDS lepB NC_009053.1 612953 613912 D Signal peptidase I 612953..613912 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849355 YP_001053250.1 CDS rnc NC_009053.1 614009 614680 D cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity; ribonuclease III 614009..614680 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849615 YP_001053251.1 CDS era NC_009053.1 614750 615664 D Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome; GTP-binding protein Era 614750..615664 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850396 YP_001053252.1 CDS recO NC_009053.1 615674 616396 D involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA; DNA repair protein RecO 615674..616396 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850408 YP_001053253.1 CDS tadG NC_009053.1 616487 618049 R tight adherence protein G complement(616487..618049) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849175 YP_001053254.1 CDS tadF NC_009053.1 618073 618669 R tight adherence protein F complement(618073..618669) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848562 YP_001053255.1 CDS tadE NC_009053.1 618641 619126 R tight adherence protein E complement(618641..619126) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849200 YP_001053256.1 CDS tadD NC_009053.1 619129 619881 R tight adherence protein D complement(619129..619881) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849202 YP_001053257.1 CDS tadC NC_009053.1 619871 620716 R tight adherence protein C complement(619871..620716) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850248 YP_001053258.1 CDS tadB NC_009053.1 620716 621603 R tight adherence protein B complement(620716..621603) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850182 YP_001053259.1 CDS tadA NC_009053.1 621603 622880 R tight adherence protein A complement(621603..622880) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850372 YP_001053260.1 CDS tadZ NC_009053.1 622889 624016 R flp operon protein D complement(622889..624016) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849780 YP_001053261.1 CDS rcpB NC_009053.1 624179 624682 R rough colony protein B complement(624179..624682) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850518 YP_001053262.1 CDS rcpA NC_009053.1 624679 626067 R rough colony protein A complement(624679..626067) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849021 YP_001053263.1 CDS rcpC NC_009053.1 626057 626875 R flp operon protein C complement(626057..626875) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848477 YP_001053264.1 CDS tadV NC_009053.1 626904 627332 R flp operon protein B complement(626904..627332) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849976 YP_001053265.1 CDS flp2 NC_009053.1 627377 627568 R minor fimbrial protein complement(627377..627568) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849062 YP_001053266.1 CDS flp1 NC_009053.1 627628 627858 R fimbrial protein Flp precursor complement(627628..627858) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849348 YP_001053267.1 CDS rhlB NC_009053.1 628451 629671 D ATP-dependent RNA helicase RhlB 628451..629671 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849037 YP_001053268.1 CDS APL_0561 NC_009053.1 629789 630211 D hypothetical protein 629789..630211 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850237 YP_001053269.1 CDS APL_0562 NC_009053.1 630262 631746 D hypothetical protein 630262..631746 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848600 YP_001053270.1 CDS afuA_2 NC_009053.1 631946 632977 D Fe3+ ABC transporter substrate-binding protein 631946..632977 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848663 YP_001053271.1 CDS afuB_2 NC_009053.1 633109 635109 D ferric transport system permease protein 633109..635109 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849067 YP_001053272.1 CDS cirA NC_009053.1 635398 638538 D ABC transporter ATP-binding protein 635398..638538 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848927 YP_001053273.1 CDS rpsB NC_009053.1 638803 639519 D one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit; 30S ribosomal protein S2 638803..639519 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848938 YP_001053274.1 CDS tsf NC_009053.1 639615 640466 D EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu; elongation factor Ts 639615..640466 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848776 YP_001053275.1 CDS APL_0568 NC_009053.1 640596 642149 R hypothetical protein complement(640596..642149) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850433 YP_001053276.1 CDS pyrH NC_009053.1 642261 642974 D Catalyzes the phosphorylation of UMP to UDP; uridylate kinase 642261..642974 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850270 YP_001053277.1 CDS frr NC_009053.1 643158 643715 D Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs; ribosome recycling factor 643158..643715 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850072 YP_001053278.1 CDS gntR NC_009053.1 643793 645193 R HTH-type transcriptional regulator complement(643793..645193) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849775 YP_001053279.1 CDS pdxS NC_009053.1 645280 646167 D with PdxT forms pyridoxal 5'-phosphate from glutamine, either ribose 5-phosphate or ribulose 5-phosphate, and either glyceraldehyde 3-phosphate or dihydroxyacetone phosphate; pyridoxal biosynthesis lyase PdxS 645280..646167 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850439 YP_001053280.1 CDS pdxT NC_009053.1 646167 646742 D with PdxST is involved in the biosynthesis of pyridoxal 5'-phosphate; PdxT catalyzes the hydrolysis of glutamine to glutamate and ammonia; PdxS utilizes the ammonia to synthesize pyridoxal 5'-phosphate; glutamine amidotransferase subunit PdxT 646167..646742 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848573 YP_001053281.1 CDS APL_0574 NC_009053.1 646816 647385 R tRNA-specific adenosine deaminase complement(646816..647385) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850221 YP_001053282.1 CDS deaD NC_009053.1 647423 649282 R cold-shock DEAD box protein A-like protein complement(647423..649282) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849259 YP_001053283.1 CDS nlpI NC_009053.1 649504 650445 R lipoprotein that appears to be involved in cell division; interacts with the periplasmic protease Prc and may be activated by protease processing; lipoprotein NlpI complement(649504..650445) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848726 YP_001053284.1 CDS pnp NC_009053.1 650506 652653 R polynucleotide phosphorylase/polyadenylase complement(650506..652653) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849054 YP_001053285.1 CDS parC NC_009053.1 652954 655200 D decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit A 652954..655200 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848482 YP_001053286.1 CDS mukF NC_009053.1 655340 656671 D acts with MukB and MukE to condense the chromosome and allow for segregation during cell division; condesin subunit F 655340..656671 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849076 YP_001053287.1 CDS mukE NC_009053.1 656751 657464 D acts with MukB and MukF to condense the chromosome and allow for segregation during cell division; condesin subunit E 656751..657464 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849385 YP_001053288.1 CDS mukB NC_009053.1 657485 661975 D SMC (structural maintenance of chromosomes) family of proteins; involved in chromosome condensatin and partitioning; forms a homodimer and the C-terminal is essential for DNA-binding activity while the purified N-terminal domain binds FtsZ; mutations result in cell division defects; cell division protein MukB 657485..661975 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850470 YP_001053289.1 CDS sotB NC_009053.1 662052 663227 D sugar efflux transporter 662052..663227 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849327 YP_001053290.1 CDS APL_0583 NC_009053.1 663279 665018 R hypothetical protein complement(663279..665018) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850228 YP_001053291.1 CDS APL_0584 NC_009053.1 665021 665242 R hypothetical protein complement(665021..665242) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850272 YP_001053292.1 CDS APL_0585 NC_009053.1 665452 666030 D hypothetical protein 665452..666030 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849650 YP_001053293.1 CDS APL_0586 NC_009053.1 666063 667268 D RND efflux membrane fusion protein 666063..667268 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850264 YP_001053294.1 CDS acrB NC_009053.1 667281 670400 D acriflavine resistance protein 667281..670400 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850040 YP_001053295.1 CDS glmU NC_009053.1 670619 671992 D forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis; bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 670619..671992 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848525 YP_001053296.1 CDS APL_0589 NC_009053.1 672091 672408 R hypothetical protein complement(672091..672408) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849264 YP_001053297.1 CDS APL_0590 NC_009053.1 672412 673032 R hypothetical protein complement(672412..673032) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850535 YP_001053298.1 CDS pgm NC_009053.1 673326 674984 D phosphoglucomutase/phosphomannomutase 673326..674984 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848688 YP_001053299.1 CDS guaA NC_009053.1 675066 676637 R contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway; GMP synthase complement(675066..676637) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849920 YP_001053300.1 CDS guaB NC_009053.1 677056 678519 R catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5'-monophosphate dehydrogenase complement(677056..678519) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848725 YP_001053301.1 CDS rrmJ NC_009053.1 678772 679398 D Specifically methylates the uridine in position 2552 of 23S rRNA in the fully assembled 50S ribosomal subunit; 23S rRNA methyltransferase J 678772..679398 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849193 YP_001053302.1 CDS ftsH NC_009053.1 679502 681424 D cell division protease FtsH-like protein 679502..681424 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848857 YP_001053303.1 CDS tyrP-A NC_009053.1 681662 682876 D tyrosine-specific transporter 681662..682876 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849170 YP_001053304.1 CDS tyrP-B NC_009053.1 682972 684189 D tyrosine-specific transport protein 2 682972..684189 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850138 YP_001053305.1 CDS glnD NC_009053.1 684296 686848 D PII uridylyl-transferase 684296..686848 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849164 YP_001053306.1 CDS APL_0599 NC_009053.1 686881 687279 R hypothetical protein complement(686881..687279) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848946 YP_001053307.1 CDS rplM NC_009053.1 687584 688012 D in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit; 50S ribosomal protein L13 687584..688012 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848534 YP_001053308.1 CDS rpsI NC_009053.1 688029 688424 D forms a direct contact with the tRNA during translation; 30S ribosomal protein S9 688029..688424 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848734 YP_001053309.1 CDS APL_0602 NC_009053.1 688546 689328 D hypothetical protein 688546..689328 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848765 YP_001053310.1 CDS APL_0603 NC_009053.1 689328 689873 D hypothetical protein 689328..689873 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849718 YP_001053311.1 CDS fieF NC_009053.1 689899 690822 D cation-efflux pump FieF 689899..690822 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849335 YP_001053312.1 CDS APL_0605 NC_009053.1 690803 691573 D hypothetical protein 690803..691573 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850384 YP_001053313.1 CDS APL_0606 NC_009053.1 691672 692997 D symporter protein 691672..692997 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848957 YP_001053314.1 CDS nfnB NC_009053.1 693099 693761 R NAD(P)H nitroreductase complement(693099..693761) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850503 YP_001053315.1 CDS pheS NC_009053.1 694038 695024 D catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily; phenylalanyl-tRNA synthetase subunit alpha 694038..695024 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850547 YP_001053316.1 CDS pheT NC_009053.1 695123 697510 D catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily; phenylalanyl-tRNA synthetase subunit beta 695123..697510 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850009 YP_001053317.1 CDS ihfA NC_009053.1 697528 697824 D This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control; integration host factor subunit alpha 697528..697824 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848771 YP_001053318.1 CDS APL_0611 NC_009053.1 697885 698409 D lipoprotein 697885..698409 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849078 YP_001053319.1 CDS APL_0612 NC_009053.1 698682 699464 R transposase complement(698682..699464) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849864 YP_001053320.1 CDS APL_0613 NC_009053.1 699506 700015 R transposase complement(699506..700015) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850205 YP_001053321.1 CDS bioD NC_009053.1 700088 700807 R DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium; dithiobiotin synthetase complement(700088..700807) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849152 YP_001053322.1 CDS mlc NC_009053.1 700861 702051 R transcriptional repressor of carbohydrate metabolism complement(700861..702051) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850158 YP_001053323.1 CDS rnd NC_009053.1 702230 703345 D ribonuclease D 702230..703345 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849996 YP_001053324.1 CDS lrp NC_009053.1 703430 703912 D mediates a global response to leucine; acts as a regulator for several genes involved in the high-affinity branched-chain amino acid transport system; leucine-responsive transcriptional regulator 703430..703912 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849728 YP_001053325.1 CDS ftsK NC_009053.1 703924 706794 D DNA translocase FtsK 703924..706794 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849416 YP_001053326.1 CDS APL_0619 NC_009053.1 706979 707842 D hypothetical protein 706979..707842 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848928 YP_001053327.1 CDS aroG NC_009053.1 707965 709038 D catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase 707965..709038 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850370 YP_001053328.1 CDS APL_0621 NC_009053.1 709142 709834 D M22-like peptidase 709142..709834 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849704 YP_001053329.1 CDS tdk NC_009053.1 710274 710855 R catalyzes the formation of thymidine 5'-phosphate from thymidine; thymidine kinase complement(710274..710855) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850310 YP_001053330.1 CDS APL_0623 NC_009053.1 710915 711133 R hypothetical protein complement(710915..711133) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849561 YP_001053331.1 CDS glpX NC_009053.1 711318 712316 D type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese; fructose 1,6-bisphosphatase II 711318..712316 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850452 YP_001053332.1 CDS APL_0625 NC_009053.1 712379 713152 R hypothetical protein complement(712379..713152) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849628 YP_001053333.1 CDS macB NC_009053.1 713244 715166 R macrolide-specific ABC-type efflux carrier complement(713244..715166) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848569 YP_001053334.1 CDS APL_0627 NC_009053.1 715311 716195 R two-component sensor protein complement(715311..716195) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850430 YP_001053335.1 CDS APL_0628 NC_009053.1 716424 716711 R hypothetical protein complement(716424..716711) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850506 YP_001053336.1 CDS cpxR NC_009053.1 716776 717504 R transcriptional regulatory protein CpxR complement(716776..717504) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849870 YP_001053337.1 CDS mazG NC_009053.1 717629 718228 R pyrophosphatase complement(717629..718228) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849382 YP_001053338.1 CDS accD NC_009053.1 718567 719460 D catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits; acetyl-CoA carboxylase subunit beta 718567..719460 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848891 YP_001053339.1 CDS folC NC_009053.1 719517 720821 D bifunctional folylpolyglutamate synthase/dihydrofolate synthase 719517..720821 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849235 YP_001053340.1 CDS hsdM3 NC_009053.1 721030 722595 D type I modification enzyme 721030..722595 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849470 YP_001053341.1 CDS hsdS3 NC_009053.1 722739 723980 D type I restriction system specificity protein 722739..723980 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848919 YP_001053342.1 CDS APL_0635 NC_009053.1 724156 724608 D hypothetical protein 724156..724608 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850112 YP_001053343.1 CDS hsdR3 NC_009053.1 724743 727883 D type I site-specific restriction-modification system, restriction subunit 724743..727883 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848782 YP_001053344.1 CDS APL_0637 NC_009053.1 728268 728729 D in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins; hypothetical protein 728268..728729 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850438 YP_001053345.1 CDS nusA NC_009053.1 728746 730227 D modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination; transcription elongation factor NusA 728746..730227 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849882 YP_001053346.1 CDS infB NC_009053.1 730249 732774 D Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; translation initiation factor IF-2 730249..732774 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850027 YP_001053347.1 CDS rbfA NC_009053.1 732946 733329 D associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock; ribosome-binding factor A 732946..733329 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850241 YP_001053348.1 CDS truB NC_009053.1 733330 734247 D catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs; tRNA pseudouridine synthase B 733330..734247 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848654 YP_001053349.1 CDS mltB NC_009053.1 734293 735381 D membrane-bound lytic murein transglycosylase B 734293..735381 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848752 YP_001053350.1 CDS APL_0643 NC_009053.1 735510 735695 D hypothetical protein 735510..735695 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848605 YP_001053351.1 CDS pta NC_009053.1 735814 737952 R catalyzes the synthesis of acetylphosphate or propionylphosphate from acetyl-CoA or propionyl-CoA and inorganic phosphate; when using propionyl-CoA the enzyme is functioning in the anaerobic pathway catabolizing threonine to propionate; phosphate acetyltransferase complement(735814..737952) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849927 YP_001053352.1 CDS ackA NC_009053.1 738008 739216 R AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA; acetate kinase complement(738008..739216) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848842 YP_001053353.1 CDS cpdB NC_009053.1 739513 741489 D periplasmic enzyme; functions during ribonucleic acid degradation; 2',3'-cyclic nucleotides are first converted to 3'-nucleotide and then cleaved to yield a ribonucleotide and a phosphate; bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic protein 739513..741489 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848735 YP_001053354.1 CDS ompP2 NC_009053.1 742439 743515 R Outer membrane protein P2 precursor (OMP P2) complement(742439..743515) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849863 YP_001053355.1 CDS APL_0650 NC_009053.1 743985 744506 D hypothetical protein 743985..744506 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849038 YP_001053356.1 CDS galU NC_009053.1 744538 745425 R UTP--glucose-1-phosphate uridylyltransferase complement(744538..745425) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849515 YP_001053357.1 CDS manB NC_009053.1 745538 746896 R phosphomannomutase complement(745538..746896) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849846 YP_001053358.1 CDS csrA NC_009053.1 746931 747125 R affects carbohydrate metabolism; has regulatory role in many processes; carbon storage regulator complement(746931..747125) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849837 YP_001053359.1 CDS alaS NC_009053.1 747203 749827 R Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; alanyl-tRNA synthetase complement(747203..749827) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849910 YP_001053360.1 CDS uspA NC_009053.1 750053 750478 R universal stress protein A-like protein complement(750053..750478) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850314 YP_001053361.1 CDS hlyX NC_009053.1 750742 751509 D Global transcription factor that controls the expression of over 100 target genes in response to anoxia; fumarate/nitrate reduction transcriptional regulator 750742..751509 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850318 YP_001053362.1 CDS sspB NC_009053.1 751608 752024 R ClpXP protease specificity-enhancing factor complement(751608..752024) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849260 YP_001053363.1 CDS sspA NC_009053.1 752024 752668 R stringent starvation protein A-like protein complement(752024..752668) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849760 YP_001053364.1 CDS purE NC_009053.1 752887 753381 D phosphoribosylaminoimidazole carboxylase catalytic subunit 752887..753381 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849665 YP_001053365.1 CDS ansB NC_009053.1 753391 754356 D L-asparaginase 753391..754356 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850050 YP_001053366.1 CDS purK NC_009053.1 754466 755554 D With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase ATPase subunit 754466..755554 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850178 YP_001053367.1 CDS aspC NC_009053.1 755686 756882 D catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate; aromatic amino acid aminotransferase 755686..756882 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849663 YP_001053368.1 CDS pepP NC_009053.1 757061 758347 R Xaa-Pro aminopeptidase complement(757061..758347) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850407 YP_001053369.1 CDS APL_0664 NC_009053.1 758756 759979 R hypothetical protein complement(758756..759979) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849866 YP_001053370.1 CDS APL_0665 NC_009053.1 760115 760504 R hypothetical protein complement(760115..760504) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849785 YP_001053371.1 CDS APL_0666 NC_009053.1 760505 760765 R hypothetical protein complement(760505..760765) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849419 YP_001053372.1 CDS uvrB NC_009053.1 760899 762920 R The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion; excinuclease ABC subunit B complement(760899..762920) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849100 YP_001053373.1 CDS APL_0668 NC_009053.1 763097 763909 D hypothetical protein 763097..763909 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849710 YP_001053374.1 CDS APL_0669 NC_009053.1 763924 765114 D iron dependent peroxidase 763924..765114 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849234 YP_001053375.1 CDS APL_0670 NC_009053.1 765125 765745 D Fe2+/Pb2+ permease 765125..765745 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849632 YP_001053376.1 CDS trpH NC_009053.1 765785 766603 R TrpH-like protein complement(765785..766603) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850309 YP_001053377.1 CDS APL_0672 NC_009053.1 766607 767197 R hypothetical protein complement(766607..767197) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848893 YP_001053378.1 CDS sbcB NC_009053.1 767214 768758 R Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates; exonuclease I complement(767214..768758) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849733 YP_001053379.1 CDS APL_0674 NC_009053.1 769000 770406 R hypothetical protein complement(769000..770406) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850507 YP_001053380.1 CDS asnC NC_009053.1 770614 772017 D catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; asparaginyl-tRNA synthetase 770614..772017 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850404 YP_001053381.1 CDS APL_0676 NC_009053.1 772121 773122 R hypothetical protein complement(772121..773122) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850486 YP_001053382.1 CDS APL_0677 NC_009053.1 773209 773772 R hypothetical protein complement(773209..773772) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849743 YP_001053383.1 CDS efp NC_009053.1 773923 774489 D Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA; elongation factor P 773923..774489 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849216 YP_001053384.1 CDS glnS NC_009053.1 774644 776314 D catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; glutaminyl-tRNA synthetase 774644..776314 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850177 YP_001053385.1 CDS APL_0680 NC_009053.1 776545 777936 R transporter complement(776545..777936) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849818 YP_001053386.1 CDS APL_0681 NC_009053.1 778118 780226 R soluble lytic murein transglycosylase complement(778118..780226) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848758 YP_001053387.1 CDS hpt NC_009053.1 780335 780874 R yypoxanthine phosphoribosyltransferase complement(780335..780874) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849400 YP_001053388.1 CDS metB NC_009053.1 780978 782114 R catalyzes the formation of cysteine from cystathionine; in B. subtilis also has O-acetylhomoserine thiolyase activity; cystathionine gamma-synthase complement(780978..782114) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850199 YP_001053389.1 CDS dapB NC_009053.1 782228 783037 R catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate reductase complement(782228..783037) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849484 YP_001053390.1 CDS mtfA NC_009053.1 783146 784237 R RNA 2'-O-ribose methyltransferase complement(783146..784237) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850086 YP_001053391.1 CDS APL_0686 NC_009053.1 784609 785013 R hypothetical protein complement(784609..785013) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850231 YP_001053392.1 CDS dld NC_009053.1 785117 786808 D component of the membrane-bound D-lactate oxidase, FAD-binding, NADH independent; D-lactate dehydrogenase 785117..786808 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848915 YP_001053393.1 CDS torZ NC_009053.1 786946 789420 R trimethylamine-N-oxide reductase precursor complement(786946..789420) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849281 YP_001053394.1 CDS torY NC_009053.1 789616 790734 R cytochrome c-type protein TorY complement(789616..790734) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849696 YP_001053395.1 CDS moaA NC_009053.1 791084 792106 D together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z; molybdenum cofactor biosynthesis protein A 791084..792106 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848653 YP_001053396.1 CDS moaC NC_009053.1 792354 792830 D molybdenum cofactor biosynthesis protein C 792354..792830 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849808 YP_001053397.1 CDS moaD NC_009053.1 792852 793097 D molybdopterin-converting factor subunit 1 792852..793097 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849322 YP_001053398.1 CDS moaE NC_009053.1 793098 793553 D molybdopterin-converting factor subunit 2 793098..793553 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850230 YP_001053399.1 CDS APL_0694 NC_009053.1 793634 794125 D metalloprotease 793634..794125 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849394 YP_001053400.1 CDS APL_0695 NC_009053.1 794137 795927 D hypothetical protein 794137..795927 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849978 YP_001053401.1 CDS topA NC_009053.1 795991 798600 R catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity; DNA topoisomerase I complement(795991..798600) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848978 YP_001053402.1 CDS APL_0697 NC_009053.1 798742 799638 D HTH-type transcriptional regulator 798742..799638 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849703 YP_001053403.1 CDS argA NC_009053.1 799732 801045 R catalyzes the formation of N-acetyl-L-glutamate from L-glutamate and acetyl-CoA in arginine biosynthesis; N-acetylglutamate synthase complement(799732..801045) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848575 YP_001053404.1 CDS aroA NC_009053.1 801193 802491 R catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis; 3-phosphoshikimate 1-carboxyvinyltransferase complement(801193..802491) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848647 YP_001053405.1 CDS hisC NC_009053.1 802505 803599 R catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis; histidinol-phosphate aminotransferase complement(802505..803599) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849807 YP_001053406.1 CDS APL_0701 NC_009053.1 803799 805067 R O-acetylhomoserine (thiol)-lyase complement(803799..805067) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849265 YP_001053407.1 CDS serC NC_009053.1 805273 806361 R catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; required both in major phosphorylated pathway of serine biosynthesis and in the biosynthesis of pyridoxine; phosphoserine aminotransferase complement(805273..806361) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848737 YP_001053408.1 CDS APL_0703 NC_009053.1 806555 809425 R ATP-dependent helicase complement(806555..809425) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850296 YP_001053409.1 CDS APL_0704 NC_009053.1 809425 812742 R hypothetical protein complement(809425..812742) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849186 YP_001053410.1 CDS APL_0705 NC_009053.1 813144 816032 R methylation subunit, type III restriction-modification system complement(813144..816032) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849014 YP_001053411.1 CDS APL_0706 NC_009053.1 816312 817184 R HTH-type transcriptional regulator complement(816312..817184) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849799 YP_001053412.1 CDS APL_0707 NC_009053.1 817194 817661 R hypothetical protein complement(817194..817661) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850560 YP_001053413.1 CDS ppx NC_009053.1 817862 819370 R exopolyphosphatase complement(817862..819370) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850477 YP_001053414.1 CDS APL_0709 NC_009053.1 819579 819914 D hypothetical protein 819579..819914 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849813 YP_001053415.1 CDS lysC NC_009053.1 820409 821761 D catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; functions in amino acid biosynthesis; lysine sensitive; aspartate kinase III 820409..821761 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848679 YP_001053416.1 CDS nrdR NC_009053.1 821887 822336 R transcriptional regulator NrdR complement(821887..822336) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849670 YP_001053417.1 CDS APL_0712 NC_009053.1 822336 822575 R hypothetical protein complement(822336..822575) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849856 YP_001053418.1 CDS dnaB NC_009053.1 822613 824076 R replicative DNA helicase complement(822613..824076) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849493 YP_001053419.1 CDS APL_0714 NC_009053.1 824256 825164 D ABC transport system periplasmic protein 824256..825164 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849876 YP_001053420.1 CDS APL_0715 NC_009053.1 825251 826198 D ABC transporter permease 825251..826198 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850229 YP_001053421.1 CDS APL_0716 NC_009053.1 826261 827139 D iron(III) ABC transporter permease 826261..827139 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848954 YP_001053422.1 CDS APL_0717 NC_009053.1 827141 827899 D iron(III) ABC transporter ATP-binding protein 827141..827899 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849885 YP_001053423.1 CDS APL_0718 NC_009053.1 828088 828768 D hypothetical protein 828088..828768 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850330 YP_001053424.1 CDS APL_0719 NC_009053.1 828778 830040 D phosphate permease 828778..830040 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849064 YP_001053425.1 CDS APL_0720 NC_009053.1 830104 830709 D hypothetical protein 830104..830709 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849359 YP_001053426.1 CDS APL_0721 NC_009053.1 830763 830990 R hypothetical protein complement(830763..830990) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849126 YP_001053427.1 CDS APL_0722 NC_009053.1 830997 831512 R hypothetical protein complement(830997..831512) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849699 YP_001053428.1 CDS tgt NC_009053.1 831585 832733 R Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr); queuine tRNA-ribosyltransferase complement(831585..832733) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849571 YP_001053429.1 CDS APL_0724 NC_009053.1 833056 833628 D hypothetical protein 833056..833628 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849286 YP_001053430.1 CDS cspD NC_009053.1 833751 833942 D cold shock-like protein CspD 833751..833942 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850493 YP_001053431.1 CDS APL_0726 NC_009053.1 834060 834776 D carbonic anhydrase 834060..834776 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848775 YP_001053432.1 CDS ilvI NC_009053.1 835093 836817 D acetolactate synthase large subunit; catalyzes the formation of 2-acetolactate from pyruvate; acetolactate synthase 3 catalytic subunit 835093..836817 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848759 YP_001053433.1 CDS ilvH NC_009053.1 836810 837301 D with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit; acetolactate synthase 3 regulatory subunit 836810..837301 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850448 YP_001053434.1 CDS pmbA NC_009053.1 837571 838920 R antibiotic maturation factor complement(837571..838920) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850502 YP_001053435.1 CDS APL_0730 NC_009053.1 839028 839558 D hypothetical protein 839028..839558 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848560 YP_001053436.1 CDS APL_0731 NC_009053.1 839603 839974 D hypothetical protein 839603..839974 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850255 YP_001053437.1 CDS ubiX NC_009053.1 840034 840606 D aromatic acid decarboxylase 840034..840606 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848808 YP_001053438.1 CDS APL_0733 NC_009053.1 840609 841322 D hypothetical protein 840609..841322 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850551 YP_001053439.1 CDS APL_0734 NC_009053.1 841369 841818 D hypothetical protein 841369..841818 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849761 YP_001053440.1 CDS APL_0735 NC_009053.1 841891 842202 R involved in start site selection during the initiation of translation; translation initiation factor Sui1 complement(841891..842202) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850544 YP_001053441.1 CDS pyrF NC_009053.1 842282 842974 R type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase; orotidine 5'-phosphate decarboxylase complement(842282..842974) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849199 YP_001053442.1 CDS APL_0737 NC_009053.1 842999 844195 R hypothetical protein complement(842999..844195) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849523 YP_001053443.1 CDS APL_0738 NC_009053.1 844195 844485 R hypothetical protein complement(844195..844485) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849112 YP_001053444.1 CDS ihfB NC_009053.1 844554 844835 R This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control; integration host factor subunit beta complement(844554..844835) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849982 YP_001053445.1 CDS rpsA NC_009053.1 844909 846573 R in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins; 30S ribosomal protein S1 complement(844909..846573) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848897 YP_001053446.1 CDS cmkA NC_009053.1 846670 847344 R cytidylate kinase complement(846670..847344) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848859 YP_001053447.1 CDS degS NC_009053.1 847374 848405 R protease DegS complement(847374..848405) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850201 YP_001053448.1 CDS secG NC_009053.1 848654 848980 R preprotein translocase subunit SecG complement(848654..848980) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848977 YP_001053449.1 CDS topB2 NC_009053.1 849112 851049 R decatenates replicating daughter chromosomes; DNA topoisomerase III complement(849112..851049) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848998 YP_001053450.1 CDS mepA NC_009053.1 852612 853442 R D-alanyl-D-alanine endopeptidase; functions in hydrolyzing cell wall peptidoglycan; similar to LAS metallopeptidases; forms a dimer in periplasm; penicillin-insensitive murein endopeptidase complement(852612..853442) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850197 YP_001053451.1 CDS aroC NC_009053.1 853537 854619 R catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis; chorismate synthase complement(853537..854619) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848838 YP_001053452.1 CDS APL_0749 NC_009053.1 854641 857949 R small mechanosensitive ion channel (MscS) that opens in response to stretch forces in the membrane lipid bilayer; maintains cell turgor through accumulation and release of potassium; large protein class of MscS; potassium efflux protein KefA complement(854641..857949) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849695 YP_001053453.1 CDS APL_0750 NC_009053.1 857967 861311 R small mechanosensitive ion channel (MscS) that opens in response to stretch forces in the membrane lipid bilayer; maintains cell turgor through accumulation and release of potassium; large protein class of MscS; potassium efflux protein KefA complement(857967..861311) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849564 YP_001053454.1 CDS menE NC_009053.1 861292 862722 R O-succinylbenzoic acid--CoA ligase complement(861292..862722) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850325 YP_001053455.1 CDS seqA NC_009053.1 862740 863300 R negative modulator of the initiation of chromosome replication; replication initiation regulator SeqA complement(862740..863300) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849176 YP_001053456.1 CDS APL_0753 NC_009053.1 863424 864209 D esterase/lipase 863424..864209 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849325 YP_001053457.1 CDS yecO NC_009053.1 864217 864942 D S-adenosyl-L-methionine-dependent methyltransferase 864217..864942 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850360 YP_001053458.1 CDS fabI NC_009053.1 865141 865929 D enoyl-ACP reductase 865141..865929 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850419 YP_001053459.1 CDS APL_0756 NC_009053.1 866377 866655 D hypothetical protein 866377..866655 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849324 YP_001053460.1 CDS rnb NC_009053.1 866787 868763 D Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction; exoribonuclease II 866787..868763 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850359 YP_001053461.1 CDS APL_0758 NC_009053.1 868838 869209 D hypothetical protein 868838..869209 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849238 YP_001053462.1 CDS APL_0759 NC_009053.1 869206 869892 D hypothetical protein 869206..869892 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848766 YP_001053463.1 CDS apaH NC_009053.1 869917 870729 D hydrolyzes P(1),P(4)-bis(5'-adenosyl) tetraphosphate to form 2 ADP; diadenosine tetraphosphatase 869917..870729 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849814 YP_001053464.1 CDS APL_0761 NC_009053.1 870918 871160 R hypothetical protein complement(870918..871160) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848461 YP_001053465.1 CDS APL_0762 NC_009053.1 871328 872083 D hypothetical protein 871328..872083 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850338 YP_001053466.1 CDS perM NC_009053.1 872142 873203 D permease perM-like protein 872142..873203 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849955 YP_001053467.1 CDS APL_0764 NC_009053.1 873233 874162 D hypothetical protein 873233..874162 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850215 YP_001053468.1 CDS queA NC_009053.1 874210 875295 D Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step; S-adenosylmethionine--tRNA ribosyltransferase-isomerase 874210..875295 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849804 YP_001053469.1 CDS rec2 NC_009053.1 875330 877624 R recombination protein 2 complement(875330..877624) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849683 YP_001053470.1 CDS APL_0767 NC_009053.1 877724 878938 R involved in the import of serine and threonine coupled with the import of sodium; serine/threonine transporter SstT complement(877724..878938) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849414 YP_001053471.1 CDS dgkA NC_009053.1 879187 879549 D diacylglycerol kinase 879187..879549 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850028 YP_001053472.1 CDS ushA NC_009053.1 879630 881273 D catalyzes the degradation of periplasmic UDP-glucose to uridine, glucose-1-phosphate and inorganic phosphate; specific for uridine nucleotides; bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic 879630..881273 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849444 YP_001053473.1 CDS APL_0770 NC_009053.1 881728 882330 D hypothetical protein 881728..882330 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849545 YP_001053474.1 CDS lpdA NC_009053.1 883954 885378 R E3 component of pyruvate and 2-oxoglutarate dehydrogenase complex; catalyzes the oxidation of dihydrolipoamide to lipoamide; dihydrolipoamide dehydrogenase complement(883954..885378) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849746 YP_001053475.1 CDS aceF NC_009053.1 885474 887372 R E2 component of pyruvate dehydrogenase multienzyme complex; in Escherichia coli AceF contains three N-terminal lipoyl domains; dihydrolipoamide acetyltransferase complement(885474..887372) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849635 YP_001053476.1 CDS aceE NC_009053.1 887432 890086 R E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC; pyruvate dehydrogenase subunit E1 complement(887432..890086) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849055 YP_001053477.1 CDS pyrD NC_009053.1 890441 891448 R catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors; dihydroorotate dehydrogenase 2 complement(890441..891448) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849059 YP_001053478.1 CDS prsA NC_009053.1 891522 892472 R catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase complement(891522..892472) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849903 YP_001053479.1 CDS ipk NC_009053.1 892484 893341 R An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis; 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase complement(892484..893341) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850291 YP_001053480.1 CDS lolB NC_009053.1 893351 893983 R Incorporates lipoproteins in the outer membrane after they are released by the LolA protein; outer membrane lipoprotein LolB complement(893351..893983) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848899 YP_001053481.1 CDS msbA NC_009053.1 894112 895860 R involved in the transport of lipid A across the inner membrane; lipid transporter ATP-binding protein/permease complement(894112..895860) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850141 YP_001053482.1 CDS APL_0779 NC_009053.1 895965 896651 R hypothetical protein complement(895965..896651) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850262 YP_001053483.1 CDS APL_0780 NC_009053.1 896661 897020 R hypothetical protein complement(896661..897020) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850300 YP_001053484.1 CDS APL_0781 NC_009053.1 897087 899009 R ATP-dependent helicase complement(897087..899009) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848640 YP_001053485.1 CDS uvrA NC_009053.1 899489 902317 R The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate; excinuclease ABC subunit A complement(899489..902317) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850311 YP_001053486.1 CDS ssb NC_009053.1 902468 902992 D binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA; single-stranded DNA-binding protein 902468..902992 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848611 YP_001053487.1 CDS APL_0784 NC_009053.1 903161 903979 R hypothetical protein complement(903161..903979) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849461 YP_001053488.1 CDS APL_0785 NC_009053.1 904303 906294 R hypothetical protein complement(904303..906294) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848781 YP_001053489.1 CDS APL_0786 NC_009053.1 906716 907804 R hypothetical protein complement(906716..907804) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849488 YP_001053490.1 CDS APL_0787 NC_009053.1 907871 909199 R ATPase complement(907871..909199) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849802 YP_001053491.1 CDS APL_0788 NC_009053.1 909512 910399 R transcriptional regulator complement(909512..910399) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848968 YP_001053492.1 CDS APL_0789 NC_009053.1 910504 911478 D dioxygenase 910504..911478 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849149 YP_001053493.1 CDS APL_0792 NC_009053.1 913424 914191 R hypothetical protein complement(913424..914191) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850059 YP_001053494.1 CDS sapD NC_009053.1 914274 915311 R peptide transport system ATP-binding protein SapD complement(914274..915311) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849957 YP_001053495.1 CDS sapC NC_009053.1 915325 916212 R peptide transport system permease SapC complement(915325..916212) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850239 YP_001053496.1 CDS sapB NC_009053.1 916202 917164 R peptide transport system permease SapB complement(916202..917164) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849406 YP_001053497.1 CDS sapA NC_009053.1 917164 918861 R peptide transport periplasmic protein SapA complement(917164..918861) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850200 YP_001053498.1 CDS tyrR NC_009053.1 918871 920019 R transcriptional regulatory protein TyrR complement(918871..920019) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848644 YP_001053499.1 CDS gmhA NC_009053.1 920224 920808 D catalyzes the isomerization of sedoheptulose 7-phosphate to D-glycero-D-manno-heptose 7-phosphate; phosphoheptose isomerase 920224..920808 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849187 YP_001053500.1 CDS APL_0799 NC_009053.1 921300 921911 D hypothetical protein 921300..921911 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849393 YP_001053501.1 CDS pckA NC_009053.1 922121 923731 R PEP carboxykinase; PEP carboxylase; PEPCK; catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using ATP; phosphoenolpyruvate carboxykinase complement(922121..923731) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848958 YP_001053502.1 CDS ftsB NC_009053.1 924004 924282 D cell division protein FtsB-like protein 924004..924282 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849566 YP_001053503.1 CDS ispD NC_009053.1 924298 924984 D 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 924298..924984 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850225 YP_001053504.1 CDS ispF NC_009053.1 924981 925457 D catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate; 2-C-methyl-D-erythritol 2,4-cyclo diphosphate synthase 924981..925457 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850073 YP_001053505.1 CDS APL_0804 NC_009053.1 926126 928102 R hypothetical protein complement(926126..928102) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850211 YP_001053506.1 CDS APL_0805 NC_009053.1 928140 928928 R hypothetical protein complement(928140..928928) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848840 YP_001053507.1 CDS xseB NC_009053.1 929073 929297 D catalyzes the bidirectional exonucleolytic cleavage of DNA; exodeoxyribonuclease VII small subunit 929073..929297 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849309 YP_001053508.1 CDS ispA NC_009053.1 929306 930199 D geranyltranstransferase 929306..930199 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850324 YP_001053509.1 CDS APL_0808 NC_009053.1 930283 930627 R hypothetical protein complement(930283..930627) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849333 YP_001053510.1 CDS lysS NC_009053.1 930728 932230 R class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1; lysyl-tRNA synthetase complement(930728..932230) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849593 YP_001053511.1 CDS cafA NC_009053.1 932365 933840 R involved in the processing of the 5'end of 16S rRNA; ribonuclease G complement(932365..933840) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849973 YP_001053512.1 CDS APL_0811 NC_009053.1 934070 935833 D hypothetical protein 934070..935833 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848751 YP_001053513.1 CDS res NC_009053.1 935866 938478 R type III restriction enzyme complement(935866..938478) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849815 YP_001053514.1 CDS mod NC_009053.1 938618 940465 R type III restriction-modification system methyltransferase complement(938618..940465) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849673 YP_001053515.1 CDS APL_0814 NC_009053.1 940675 941637 D hypothetical protein 940675..941637 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850246 YP_001053516.1 CDS APL_0815 NC_009053.1 941783 942118 D hypothetical protein 941783..942118 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848762 YP_001053517.1 CDS mltA NC_009053.1 942185 943282 R membrane-bound, lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; murein transglycosylase A complement(942185..943282) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849552 YP_001053518.1 CDS xseA NC_009053.1 943691 945151 D bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides; exodeoxyribonuclease VII large subunit 943691..945151 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848764 YP_001053519.1 CDS APL_0818 NC_009053.1 945527 945940 R transthyretin-like periplasmic protein complement(945527..945940) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850323 YP_001053520.1 CDS purR NC_009053.1 946139 947149 D binds to the purF operator and coregulates other genes for de novo purine nucleotide synthesis; is involved in regulation of purB, purC, purEK, purHD, purL, purMN and guaBA expression; binds hypoxanthine and guanine as inducers; DNA-binding transcriptional repressor PurR 946139..947149 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849135 YP_001053521.1 CDS APL_0820 NC_009053.1 947172 947774 D membrane-associated protein 947172..947774 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849330 YP_001053522.1 CDS gyrB NC_009053.1 947874 950306 R DNA gyrase subunit B complement(947874..950306) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850065 YP_001053523.1 CDS ubiA NC_009053.1 950519 951400 R catalyzes the conversion of 4-Hydroxybenzoate into 3-octaprenyl-4-hydroxybenzoate, as part of the ubiquinone biosynthesis pathway; 4-hydroxybenzoate octaprenyltransferase complement(950519..951400) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850044 YP_001053524.1 CDS glpR NC_009053.1 951400 952161 R glycerol-3-phosphate regulon repressor complement(951400..952161) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849004 YP_001053525.1 CDS purB NC_009053.1 952229 953596 R Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; adenylosuccinate lyase complement(952229..953596) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849396 YP_001053526.1 CDS APL_0825 NC_009053.1 953653 954285 R HflD; UPF0274; in Escherichia coli this protein is peripherally associated with the membrane and appears to act with lambda CII protein; in Haemophilus influenzae a knockout of the HI0638 gene affected paracytosis; hypothetical protein complement(953653..954285) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850190 YP_001053527.1 CDS cydC NC_009053.1 954450 956117 R in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c; cysteine/glutathione ABC transporter membrane/ATP-binding protein complement(954450..956117) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849282 YP_001053528.1 CDS cydD NC_009053.1 956128 957870 R in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c; cysteine/glutathione ABC transporter membrane/ATP-binding protein complement(956128..957870) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849570 YP_001053529.1 CDS APL_0828 NC_009053.1 958030 961989 R hypothetical protein complement(958030..961989) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848988 YP_001053530.1 CDS APL_0829 NC_009053.1 962050 963876 R hypothetical protein complement(962050..963876) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848551 YP_001053531.1 CDS APL_0830 NC_009053.1 963892 964740 R hypothetical protein complement(963892..964740) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849001 YP_001053532.1 CDS APL_0831 NC_009053.1 964740 965939 R membrane-bound metallopeptidase complement(964740..965939) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848739 YP_001053533.1 CDS gpmA NC_009053.1 966118 966801 D 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate; phosphoglyceromutase 966118..966801 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848641 YP_001053534.1 CDS APL_0833 NC_009053.1 966885 967520 R hypothetical protein complement(966885..967520) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848802 YP_001053535.1 CDS udk NC_009053.1 967638 968291 D functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor; uridine kinase 967638..968291 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849621 YP_001053536.1 CDS dcd NC_009053.1 968300 968884 D Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis; deoxycytidine triphosphate deaminase 968300..968884 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849342 YP_001053537.1 CDS APL_0836 NC_009053.1 968953 969507 R transcriptional regulator complement(968953..969507) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849542 YP_001053538.1 CDS APL_0837 NC_009053.1 969648 970709 D hypothetical protein 969648..970709 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849069 YP_001053539.1 CDS APL_0838 NC_009053.1 970713 973454 D ABC transporter ATP-binding protein 970713..973454 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850235 YP_001053540.1 CDS APL_0839 NC_009053.1 973456 974580 D inner membrane transport permease 973456..974580 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849830 YP_001053541.1 CDS APL_0840 NC_009053.1 974597 975991 D outer membrane protein 974597..975991 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849516 YP_001053542.1 CDS pntB NC_009053.1 976069 977517 R catalyzes reversible transfer of hydride ion equivalent between NAD and NADP; membrane-bound proton pump that translocates protons from cytosolic to periplasmic side of the inner membrane; forms a tetramer composed of two alpha and 2 beta subunits; AB-stereospecific enzyme; pyridine nucleotide transhydrogenase complement(976069..977517) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848714 YP_001053543.1 CDS pntA NC_009053.1 977528 979066 R forms a tetramer composed of 2 alpha subunits and 2 beta subunits in the inner membrane; involved in catalyzing transfer of hydride ion equivalents between NAD and NADP; stereospecific (AB-specific); functions as a proton pump by translocating protons from cytoplasm to periplasm; NAD(P) transhydrogenase subunit alpha complement(977528..979066) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849810 YP_001053544.1 CDS APL_0843 NC_009053.1 979271 980002 D tRNA/rRNA methyltransferase 979271..980002 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849914 YP_001053545.1 CDS queF NC_009053.1 980048 980887 R catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) in queuosine biosynthesis; 7-cyano-7-deazaguanine reductase complement(980048..980887) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850362 YP_001053546.1 CDS gmhB NC_009053.1 980900 981445 R Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1-phosphate; D,D-heptose 1,7-bisphosphate phosphatase complement(980900..981445) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848689 YP_001053547.1 CDS bcp NC_009053.1 981448 981918 R bacterioferritin comigratory protein; thiol peroxidase; thioredoxin-dependent; hydroperoxide peroxidase; in Escherichia coli this enzyme preferentially reduces linoleic acid hydroperoxide; contains an active site cysteine; thioredoxin-dependent thiol peroxidase complement(981448..981918) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849873 YP_001053548.1 CDS APL_0847 NC_009053.1 981993 983150 R catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase complement(981993..983150) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849506 YP_001053549.1 CDS APL_0848 NC_009053.1 983413 984987 D ABC transporter substrate-binding protein 983413..984987 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850266 YP_001053550.1 CDS APL_0849 NC_009053.1 985086 986039 D inner membrane ABC transporter permease 985086..986039 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849824 YP_001053551.1 CDS APL_0850 NC_009053.1 986039 988012 D ABC transporter ATP-binding protein/permease 986039..988012 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849075 YP_001053552.1 CDS APL_0851 NC_009053.1 988016 988822 D ABC transporter ATP-binding protein 988016..988822 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849258 YP_001053553.1 CDS APL_0852 NC_009053.1 988874 990472 D FAD flavoprotein oxidase 988874..990472 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848565 YP_001053554.1 CDS APL_0853 NC_009053.1 990534 991691 R methionine synthase II (cobalamin-independent) complement(990534..991691) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849550 YP_001053555.1 CDS metF NC_009053.1 991911 992792 D MTHFR; catalyzes NADH-linked reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate using FAD as a cofactor; 5,10-methylenetetrahydrofolate reductase 991911..992792 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848533 YP_001053556.1 CDS hbpA NC_009053.1 993070 994665 R heme-binding protein A complement(993070..994665) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848937 YP_001053557.1 CDS sdaC NC_009053.1 995022 996251 D serine transporter 995022..996251 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849667 YP_001053558.1 CDS sdaA NC_009053.1 996347 997726 D L-serine dehydratase 996347..997726 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849245 YP_001053559.1 CDS mnmC NC_009053.1 997904 999919 R catalyzes the formation of 5-methylaminomethyl-2-thiouridine in position 34 of the anticodon of tRNA molecules; 5-methylaminomethyl-2-thiouridine methyltransferase complement(997904..999919) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849445 YP_001053560.1 CDS trpCF NC_009053.1 1000124 1001533 R monomeric bifunctional protein; functions in tryptophan biosynthesis pathway; phosphoribosylanthranilate is rearranged to carboxyphenylaminodeoxyribulosephosphate which is then closed to form indole-3-glycerol phosphate; bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase complement(1000124..1001533) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849255 YP_001053561.1 CDS fic NC_009053.1 1001711 1002376 D filamentation induced by cAMP protein Fic-like protein 1001711..1002376 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848695 YP_001053562.1 CDS APL_0861 NC_009053.1 1002384 1002695 D hypothetical protein 1002384..1002695 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849624 YP_001053563.1 CDS truC NC_009053.1 1002696 1003439 D catalyzes formation of pseudouridine at position 65 in tRNA-Ile1 and tRNA-Asp; tRNA pseudouridine synthase C 1002696..1003439 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849094 YP_001053564.1 CDS APL_0863 NC_009053.1 1003441 1003605 D hypothetical protein 1003441..1003605 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849950 YP_001053565.1 CDS APL_0864 NC_009053.1 1003602 1004054 D hypothetical protein 1003602..1004054 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849652 YP_001053566.1 CDS aape0934 NC_009053.1 1004099 1004938 R hypothetical protein complement(1004099..1004938) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849365 YP_001053567.1 CDS APL_0866 NC_009053.1 1004961 1006415 D hypothetical protein 1004961..1006415 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848538 YP_001053568.1 CDS smpB NC_009053.1 1006549 1007028 D binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation; SsrA-binding protein 1006549..1007028 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849572 YP_001053569.1 CDS serS NC_009053.1 1007146 1008453 D catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; seryl-tRNA synthetase 1007146..1008453 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850467 YP_001053570.1 CDS abgB NC_009053.1 1008524 1009792 R aminobenzoyl-glutamate utilization-like protein complement(1008524..1009792) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849082 YP_001053571.1 CDS APL_0870 NC_009053.1 1009886 1011178 R C4-dicarboxylate transporter complement(1009886..1011178) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848851 YP_001053572.1 CDS pepE NC_009053.1 1011189 1011893 R alpha-aspartyl dipeptidase; catalyzes the hydrolysis of dipeptides with an N-terminal aspartate residue; belongs to peptidase S51 family; peptidase E complement(1011189..1011893) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850173 YP_001053573.1 CDS leuS NC_009053.1 1012144 1014729 D leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase; leucyl-tRNA synthetase 1012144..1014729 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849039 YP_001053574.1 CDS rlpB NC_009053.1 1014837 1015331 D rare lipoprotein B 1014837..1015331 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849269 YP_001053575.1 CDS holA NC_009053.1 1015440 1016465 D required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA; DNA polymerase III subunit delta 1015440..1016465 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849510 YP_001053576.1 CDS yacG NC_009053.1 1016542 1016730 R zinc-binding protein complement(1016542..1016730) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849655 YP_001053577.1 CDS coaE NC_009053.1 1016712 1017350 R catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis; dephospho-CoA kinase complement(1016712..1017350) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848625 YP_001053578.1 CDS apfD NC_009053.1 1017372 1018010 R pubmed:14742510; fimbrial leader peptidase complement(1017372..1018010) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850263 YP_001053579.1 CDS apfC NC_009053.1 1018037 1019239 R pubmed:14742510; fimbrial biogenesis protein complement(1018037..1019239) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848621 YP_001053580.1 CDS apfB NC_009053.1 1019223 1020617 R pubmed:14742510; fimbrial biogenesis protein complement(1019223..1020617) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849336 YP_001053581.1 CDS apfA NC_009053.1 1020635 1021081 R pubmed:14742510; type 4 prepilin subunit ApfA complement(1020635..1021081) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849505 YP_001053582.1 CDS radA NC_009053.1 1021263 1022642 D Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents; DNA repair protein RadA 1021263..1022642 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850366 YP_001053583.1 CDS APL_0882 NC_009053.1 1022686 1022919 R hypothetical protein complement(1022686..1022919) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849711 YP_001053584.1 CDS folA NC_009053.1 1023046 1023534 R dihydrofolate reductase complement(1023046..1023534) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850244 YP_001053585.1 CDS proB NC_009053.1 1023621 1024712 D catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis; gamma-glutamyl kinase 1023621..1024712 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850252 YP_001053586.1 CDS APL_0885 NC_009053.1 1024725 1025501 D hypothetical protein 1024725..1025501 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849341 YP_001053587.1 CDS nth NC_009053.1 1025502 1026134 D endonuclease III 1025502..1026134 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849103 YP_001053588.1 CDS fadI NC_009053.1 1026344 1027648 D 3-ketoacyl-CoA thiolase 1026344..1027648 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848975 YP_001053589.1 CDS fadJ NC_009053.1 1027658 1029775 D fatty acid oxidation complex subunit alpha 1027658..1029775 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849370 YP_001053590.1 CDS APL_0889 NC_009053.1 1029866 1031281 D hypothetical protein 1029866..1031281 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848552 YP_001053591.1 CDS APL_0890 NC_009053.1 1031364 1032296 R hypothetical protein complement(1031364..1032296) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848761 YP_001053592.1 CDS fdhD NC_009053.1 1032298 1033104 R formate dehydrogenase accessory protein-like protein complement(1032298..1033104) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849981 YP_001053593.1 CDS fdxG NC_009053.1 1033523 1034110 D formate dehydrogenase, nitrate-inducible, major subunit 1033523..1034110 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850066 YP_001053594.1 CDS fdxG NC_009053.1 1034159 1036582 D formate dehydrogenase, nitrate-inducible, major subunit 1034159..1036582 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848642 YP_001053595.1 CDS fdxH NC_009053.1 1036582 1037481 D formate dehydrogenase, iron-sulfur subunit 1036582..1037481 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848699 YP_001053596.1 CDS fdnI NC_009053.1 1037474 1038145 D formate dehydrogenase, cytochrome b556 subunit 1037474..1038145 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848527 YP_001053597.1 CDS fdhE NC_009053.1 1038255 1039172 D required for the formation of active formate dehydrogenase; formate dehydrogenase accessory protein FdhE 1038255..1039172 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849150 YP_001053598.1 CDS folD NC_009053.1 1039775 1040632 D catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate; bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase 1039775..1040632 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850107 YP_001053599.1 CDS APL_0898 NC_009053.1 1040777 1042315 D oxalate/formate antiporter 1040777..1042315 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848687 YP_001053600.1 CDS dapA NC_009053.1 1042413 1043300 R catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate synthase complement(1042413..1043300) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848494 YP_001053601.1 CDS lpxL NC_009053.1 1043459 1044400 R Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis lauroyl acyltransferase complement(1043459..1044400) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850171 YP_001053602.1 CDS APL_0901 NC_009053.1 1044565 1044879 D ribosome-associated inhibitor A 1044565..1044879 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848519 YP_001053603.1 CDS truA NC_009053.1 1044938 1045726 R mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability; tRNA pseudouridine synthase A complement(1044938..1045726) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850172 YP_001053604.1 CDS folE NC_009053.1 1045805 1046461 R involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer; GTP cyclohydrolase I complement(1045805..1046461) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850242 YP_001053605.1 CDS kdkA NC_009053.1 1046562 1047266 D catalyzes the phosphorylation of 3-deoxy-D-manno-octulosonic acid at the 4-OH position; 3-deoxy-D-manno-octulosonic-acid kinase 1046562..1047266 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848656 YP_001053606.1 CDS APL_0905 NC_009053.1 1047346 1047684 R hypothetical protein complement(1047346..1047684) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848731 YP_001053607.1 CDS APL_0906 NC_009053.1 1047743 1048318 R acetyltransferase complement(1047743..1048318) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849913 YP_001053608.1 CDS APL_0907 NC_009053.1 1048403 1049545 R hypothetical protein complement(1048403..1049545) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849518 YP_001053609.1 CDS APL_0908 NC_009053.1 1049704 1050588 D transcriptional regulator 1049704..1050588 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849854 YP_001053610.1 CDS plpB NC_009053.1 1050643 1051461 R outer membrane lipoprotein 2 complement(1050643..1051461) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849928 YP_001053611.1 CDS plpA NC_009053.1 1051576 1052397 R outer membrane lipoprotein 1 complement(1051576..1052397) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849722 YP_001053612.1 CDS metI NC_009053.1 1052424 1053101 R D-methionine transport system permease protein MetI complement(1052424..1053101) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849613 YP_001053613.1 CDS metN NC_009053.1 1053091 1054125 R part of the metNIQ transport system for methionine; DL-methionine transporter ATP-binding subunit complement(1053091..1054125) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848930 YP_001053614.1 CDS cysS NC_009053.1 1054323 1055702 R catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase complement(1054323..1055702) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848686 YP_001053615.1 CDS ppiB NC_009053.1 1055847 1056356 D peptidyl-prolyl cis-trans isomerase B 1055847..1056356 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849798 YP_001053616.1 CDS cca NC_009053.1 1056460 1057695 D catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template; phosphohydrolase activities include hydrolysis of pyrophosphate, 5'-nucleoside tri- and diphosphates, NADP, and 2'-AMP with the production of Pi, metal-dependent phosphodiesterase activity for 2',3'-cAMP, 2',3'-cGMP, and 2',3'-cCMP, and hydrolysis 2',3'-cyclic substrates with the formation of 2'-nucleotides and 3'-nucleotides; these phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases; multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase 1056460..1057695 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850166 YP_001053617.1 CDS APL_0916 NC_009053.1 1057930 1058280 D transposase 1057930..1058280 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848601 YP_001053618.1 CDS APL_0917 NC_009053.1 1058292 1058627 D transposase 1058292..1058627 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849459 YP_001053619.1 CDS APL_0918 NC_009053.1 1058593 1058949 D transposase 1058593..1058949 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849919 YP_001053620.1 CDS irp NC_009053.1 1059147 1061495 R iron-regulated outer membrane protein complement(1059147..1061495) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849145 YP_001053621.1 CDS APL_0920 NC_009053.1 1061681 1062937 D hypothetical protein 1061681..1062937 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849991 YP_001053622.1 CDS APL_0921 NC_009053.1 1062993 1064408 D hypothetical protein 1062993..1064408 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848683 YP_001053623.1 CDS APL_0922 NC_009053.1 1064548 1065114 R hypothetical protein complement(1064548..1065114) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850484 YP_001053624.1 CDS APL_0923 NC_009053.1 1066530 1066724 R hypothetical protein complement(1066530..1066724) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849071 YP_001053625.1 CDS fdx NC_009053.1 1066724 1067065 R 2Fe-2S ferredoxin complement(1066724..1067065) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848661 YP_001053626.1 CDS hscA NC_009053.1 1067186 1069039 R involved in the maturation of iron-sulfur cluster-containing proteins; chaperone protein HscA complement(1067186..1069039) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849751 YP_001053627.1 CDS APL_0926 NC_009053.1 1069158 1069790 R hypothetical protein complement(1069158..1069790) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850565 YP_001053628.1 CDS APL_0927 NC_009053.1 1069818 1070270 R hypothetical protein complement(1069818..1070270) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850380 YP_001053629.1 CDS hscB NC_009053.1 1070318 1070839 R J-type co-chaperone that regulates the ATPase and peptide-binding activity of Hsc66 chaperone; may function in biogenesis of iron-sulfur proteins; co-chaperone HscB complement(1070318..1070839) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849755 YP_001053630.1 CDS iscA NC_009053.1 1070849 1071172 R iron-binding protein IscA complement(1070849..1071172) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850030 YP_001053631.1 CDS nifU NC_009053.1 1071314 1071697 R scaffold protein complement(1071314..1071697) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850192 YP_001053632.1 CDS iscS NC_009053.1 1071830 1073056 R catalyzes the removal of elemental sulfur from cysteine to produce alanine; involved in NAD biosynthesis; cysteine desulfurase complement(1071830..1073056) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849774 YP_001053633.1 CDS APL_0932 NC_009053.1 1073111 1073563 R HTH-type transcriptional regulator complement(1073111..1073563) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849487 YP_001053634.1 CDS ompP1 NC_009053.1 1074053 1075444 D outer membrane protein 1074053..1075444 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848549 YP_001053635.1 CDS ogt NC_009053.1 1075530 1076093 D methylated DNA-protein cysteine methyltransferase 1075530..1076093 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848863 YP_001053636.1 CDS APL_0935 NC_009053.1 1076113 1077963 R aerobic respiration control sensor protein complement(1076113..1077963) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848563 YP_001053637.1 CDS APL_0936 NC_009053.1 1078069 1078932 R hypothetical protein complement(1078069..1078932) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850288 YP_001053638.1 CDS APL_0937 NC_009053.1 1079048 1079590 R hypothetical protein complement(1079048..1079590) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850012 YP_001053639.1 CDS bioD NC_009053.1 1079580 1080224 R DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium; dithiobiotin synthetase complement(1079580..1080224) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848856 YP_001053640.1 CDS bioC NC_009053.1 1080224 1080994 R biotin synthesis protein complement(1080224..1080994) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850409 YP_001053641.1 CDS APL_0940 NC_009053.1 1080982 1081641 R hypothetical protein complement(1080982..1081641) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849890 YP_001053642.1 CDS bioF NC_009053.1 1081651 1082814 R catalyzes the formation of 8-amino-7-oxononanoate from 6-carboxyhexanoyl-CoA and L-alanine; 8-amino-7-oxononanoate synthase complement(1081651..1082814) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848997 YP_001053643.1 CDS bioA NC_009053.1 1082841 1084139 R catalyzes the formation of S-adenosyl-4-methylthionine-2-oxobutanoate and 7,8-diaminononanoate from S-adenosyl-L-methionine and 8-amino-7-oxononanoate; adenosylmethionine-8-amino-7-oxononanoate aminotransferase complement(1082841..1084139) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849031 YP_001053644.1 CDS APL_0943 NC_009053.1 1084230 1085174 D involved in methylation of ribosomal protein L3; N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase 1084230..1085174 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849475 YP_001053645.1 CDS greA NC_009053.1 1085256 1085732 R necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreA complement(1085256..1085732) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849017 YP_001053646.1 CDS dacB NC_009053.1 1085816 1087258 D penicillin binding protein 4; penicillin sensitive; catalyzes the formation of D-alanine from D-alanyl-D-alanine; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains; D-alanyl-D-alanine carboxypeptidase 1085816..1087258 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848609 YP_001053647.1 CDS APL_0946 NC_009053.1 1087295 1087564 R hypothetical protein complement(1087295..1087564) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849030 YP_001053648.1 CDS APL_0947 NC_009053.1 1087883 1089004 R transposase complement(1087883..1089004) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850206 YP_001053649.1 CDS APL_0948 NC_009053.1 1089835 1090875 D transposase 1089835..1090875 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850053 YP_001053650.1 CDS APL_0949 NC_009053.1 1090914 1091474 R hypothetical protein complement(1090914..1091474) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849868 YP_001053651.1 CDS APL_0950 NC_009053.1 1091939 1092502 R hypothetical protein complement(1091939..1092502) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849602 YP_001053652.1 CDS APL_0951 NC_009053.1 1092656 1092964 R hypothetical protein complement(1092656..1092964) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850424 YP_001053653.1 CDS APL_0952 NC_009053.1 1093033 1094115 D transposase 1093033..1094115 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848736 YP_001053654.1 CDS APL_0953 NC_009053.1 1094115 1094549 D hypothetical protein 1094115..1094549 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850483 YP_001053655.1 CDS APL_0954 NC_009053.1 1094550 1094939 R hypothetical protein complement(1094550..1094939) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848920 YP_001053656.1 CDS apxIIB NC_009053.1 1094981 1095553 R leukotoxin translocation ATP-binding protein LktB (apxIIB) complement(1094981..1095553) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850184 YP_001053657.1 CDS apxIIA NC_009053.1 1095618 1098488 R RTX-II toxin determinant A complement(1095618..1098488) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848738 YP_001053658.1 CDS APL_0957 NC_009053.1 1099185 1100414 R hypothetical protein complement(1099185..1100414) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849786 YP_001053659.1 CDS purH NC_009053.1 1100837 1102426 D involved in de novo purine biosynthesis; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 1100837..1102426 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849104 YP_001053660.1 CDS APL_0959 NC_009053.1 1104021 1111811 R hemagglutinin/hemolysin-like protein complement(1104021..1111811) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849498 YP_001053661.1 CDS ostA NC_009053.1 1113814 1116150 R determines N-hexane tolerance and is involved in outer membrane permeability; organic solvent tolerance protein complement(1113814..1116150) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849645 YP_001053662.1 CDS hemN NC_009053.1 1116207 1117574 R catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase complement(1116207..1117574) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849323 YP_001053663.1 CDS APL_0964 NC_009053.1 1117604 1118032 R hypothetical protein complement(1117604..1118032) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848926 YP_001053664.1 CDS APL_0965 NC_009053.1 1118087 1118665 R hypothetical protein complement(1118087..1118665) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849317 YP_001053665.1 CDS APL_0966 NC_009053.1 1118814 1120472 R hypothetical protein complement(1118814..1120472) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850175 YP_001053666.1 CDS gltS NC_009053.1 1120735 1121952 D sodium/glutamate symport carrier protein 1120735..1121952 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849481 YP_001053667.1 CDS APL_0968 NC_009053.1 1122022 1122399 R hypothetical protein complement(1122022..1122399) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849974 YP_001053668.1 CDS glnE NC_009053.1 1122496 1125375 R catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme; bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase complement(1122496..1125375) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848970 YP_001053669.1 CDS APL_0970 NC_009053.1 1125450 1125716 R hypothetical protein complement(1125450..1125716) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848881 YP_001053670.1 CDS APL_0971 NC_009053.1 1125743 1126234 R acyl CoA thioester hydrolase complement(1125743..1126234) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849942 YP_001053671.1 CDS ispZ NC_009053.1 1126221 1126772 R Involved in cell division; probably involved in intracellular septation; intracellular septation protein A complement(1126221..1126772) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848571 YP_001053672.1 CDS APL_0973 NC_009053.1 1126774 1127511 R hypothetical protein complement(1126774..1127511) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849246 YP_001053673.1 CDS APL_0974 NC_009053.1 1127670 1128104 D hypothetical protein 1127670..1128104 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849118 YP_001053674.1 CDS APL_0975 NC_009053.1 1128272 1129228 D TtcA; YdaO; catalyzes the thiolation of cytosine 32 in specific tRNAs; C32 tRNA thiolase 1128272..1129228 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848931 YP_001053675.1 CDS APL_0976 NC_009053.1 1129435 1130811 D hypothetical protein 1129435..1130811 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850083 YP_001053676.1 CDS xthA NC_009053.1 1130902 1131705 D removes the damaged DNA at cytosines and guanines by cleaving on the 3' side of the AP site by a beta-elimination reaction; exonuclease III 1130902..1131705 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849520 YP_001053677.1 CDS ilvY NC_009053.1 1131769 1132653 R participates in controlling several genes involved in isoleucine and valine biosynthesis; activates the transcription of the ilvC gene in the presence of acetolactate or acetohydroxybutyrate; DNA-binding transcriptional regulator IlvY complement(1131769..1132653) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848812 YP_001053678.1 CDS lbgB NC_009053.1 1132654 1133694 R D-glycero-D-manno-heptosyl transferase complement(1132654..1133694) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849101 YP_001053679.1 CDS lbgA NC_009053.1 1133736 1134377 R LPS biosynthesis protein complement(1133736..1134377) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849398 YP_001053680.1 CDS APL_0981 NC_009053.1 1134486 1135547 D hypothetical protein 1134486..1135547 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850379 YP_001053681.1 CDS rpmE NC_009053.1 1135609 1135821 R RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 complement(1135609..1135821) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850269 YP_001053682.1 CDS tktA NC_009053.1 1136203 1138209 D catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase 1136203..1138209 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849549 YP_001053683.1 CDS APL_0984 NC_009053.1 1138339 1138848 D transposase 1138339..1138848 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849653 YP_001053684.1 CDS APL_0985 NC_009053.1 1138860 1139195 D transposase 1138860..1139195 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849725 YP_001053685.1 CDS APL_0986 NC_009053.1 1139161 1139670 D transposase-like protein 1139161..1139670 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850475 YP_001053686.1 CDS htpG NC_009053.1 1139729 1141606 R molecular chaperone; heat shock protein 90 complement(1139729..1141606) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848844 YP_001053687.1 CDS hktE NC_009053.1 1141834 1143360 D catalase 1141834..1143360 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849862 YP_001053688.1 CDS APL_0989 NC_009053.1 1143527 1143706 D transposase 1143527..1143706 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848537 YP_001053689.1 CDS APL_0990 NC_009053.1 1143726 1144064 D transposase 1143726..1144064 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850495 YP_001053690.1 CDS APL_0991 NC_009053.1 1144177 1145256 D hypothetical protein 1144177..1145256 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848793 YP_001053691.1 CDS nrdA NC_009053.1 1145469 1147739 D Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 1145469..1147739 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849859 YP_001053692.1 CDS nrdB NC_009053.1 1148036 1149166 D B2 or R2 protein; type 1a enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdA; ribonucleotide-diphosphate reductase subunit beta 1148036..1149166 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849173 YP_001053693.1 CDS galT NC_009053.1 1149428 1150477 D catalyzes the interconversion of UDP-galactose and galactose-1-P with UDP-galactose and glucose-1-P; galactose-1-phosphate uridylyltransferase 1149428..1150477 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849633 YP_001053694.1 CDS galK NC_009053.1 1150505 1151659 D catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism; galactokinase 1150505..1151659 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848693 YP_001053695.1 CDS galM NC_009053.1 1151717 1152685 D aldose 1-epimerase 1151717..1152685 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849904 YP_001053696.1 CDS lacZ NC_009053.1 1152710 1155730 D beta-galactosidase 1152710..1155730 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850088 YP_001053697.1 CDS apxIVA NC_009053.1 1155848 1161703 R pubmed:10463177; RTX toxin protein complement(1155848..1161703) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849889 YP_001053698.1 CDS APL_0999 NC_009053.1 1161732 1162208 R hypothetical protein complement(1161732..1162208) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848942 YP_001053699.1 CDS mrp NC_009053.1 1162405 1163502 R ATPase complement(1162405..1163502) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848795 YP_001053700.1 CDS APL_1001 NC_009053.1 1163506 1165056 R binding protein complement(1163506..1165056) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849908 YP_001053701.1 CDS APL_1002 NC_009053.1 1165071 1165724 R hypothetical protein complement(1165071..1165724) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849353 YP_001053702.1 CDS ppiD NC_009053.1 1165846 1167723 R peptidyl-prolyl cis-trans isomerase D complement(1165846..1167723) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848846 YP_001053703.1 CDS nhaP NC_009053.1 1167952 1169265 D Na(+)/H(+) exchanger beta-like protein 1167952..1169265 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849110 YP_001053704.1 CDS rpsO NC_009053.1 1169387 1169656 D primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence; 30S ribosomal protein S15 1169387..1169656 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850401 YP_001053705.1 CDS APL_1006 NC_009053.1 1169734 1170603 D hypothetical protein 1169734..1170603 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849838 YP_001053706.1 CDS hemY NC_009053.1 1170661 1171911 R HemY-like protein complement(1170661..1171911) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849551 YP_001053707.1 CDS hemX NC_009053.1 1171923 1173263 R uroporphyrin-III C-methyltransferase complement(1171923..1173263) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848690 YP_001053708.1 CDS hemD NC_009053.1 1173273 1174037 R uroporphyrinogen-III synthase complement(1173273..1174037) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850081 YP_001053709.1 CDS hemC NC_009053.1 1174046 1174975 R porphobilinogen deaminase complement(1174046..1174975) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849719 YP_001053710.1 CDS adh2 NC_009053.1 1175244 1177859 D Includes: Alcohol dehydrogenase; Acetaldehyde dehydrogenase; bifunctional acetaldehyde-CoA/alcohol dehydrogenase 1175244..1177859 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849056 YP_001053711.1 CDS groEL NC_009053.1 1178033 1179676 R 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth; chaperonin GroEL complement(1178033..1179676) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849874 YP_001053712.1 CDS groES NC_009053.1 1179740 1180030 R 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring; co-chaperonin GroES complement(1179740..1180030) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848835 YP_001053713.1 CDS deoD NC_009053.1 1180242 1180964 R catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate; purine nucleoside phosphorylase complement(1180242..1180964) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850479 YP_001053714.1 CDS deoC NC_009053.1 1181023 1181799 R catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate; deoxyribose-phosphate aldolase complement(1181023..1181799) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849634 YP_001053715.1 CDS APL_1016 NC_009053.1 1181936 1183204 R nucleoside transporter complement(1181936..1183204) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848934 YP_001053716.1 CDS APL_1017 NC_009053.1 1183417 1184061 D hypothetical protein 1183417..1184061 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849105 YP_001053717.1 CDS eda NC_009053.1 1184113 1184754 R catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate; keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase complement(1184113..1184754) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848777 YP_001053718.1 CDS kdgK NC_009053.1 1184769 1185713 R 2-dehydro-3-deoxygluconokinase complement(1184769..1185713) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850106 YP_001053719.1 CDS uxaC NC_009053.1 1185726 1186316 R uronate isomerase complement(1185726..1186316) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849310 YP_001053720.1 CDS APL_1021 NC_009053.1 1186618 1188096 D alpha-glucosidase 2 1186618..1188096 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849794 YP_001053721.1 CDS APL_1022 NC_009053.1 1188100 1188336 D transcriptional regulator 1188100..1188336 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849554 YP_001053722.1 CDS APL_1023 NC_009053.1 1188311 1188892 D hypothetical protein 1188311..1188892 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849073 YP_001053723.1 CDS APL_1024 NC_009053.1 1188983 1189489 D peptide methionine sulfoxide reductase MsrA 1188983..1189489 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848824 YP_001053724.1 CDS lsgF NC_009053.1 1189524 1190324 R glycosyl transferase complement(1189524..1190324) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850305 YP_001053725.1 CDS APL_1026 NC_009053.1 1190324 1191205 R glycosyltransferase complement(1190324..1191205) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848728 YP_001053726.1 CDS APL_1027 NC_009053.1 1191198 1192397 R hypothetical protein complement(1191198..1192397) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850304 YP_001053727.1 CDS APL_1028 NC_009053.1 1192398 1193168 R glycosyltransferase complement(1192398..1193168) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850037 YP_001053728.1 CDS APL_1029 NC_009053.1 1193165 1194310 R hypothetical protein complement(1193165..1194310) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850061 YP_001053729.1 CDS APL_1030 NC_009053.1 1194351 1195316 R hypothetical protein complement(1194351..1195316) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849911 YP_001053730.1 CDS APL_1031 NC_009053.1 1195472 1196212 D hypothetical protein 1195472..1196212 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849160 YP_001053731.1 CDS priA NC_009053.1 1196311 1198527 R binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity; primosome assembly protein PriA complement(1196311..1198527) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849089 YP_001053732.1 CDS pheA NC_009053.1 1198612 1199769 R Includes: Chorismate mutase; Prephenate dehydratase; P-protein complement(1198612..1199769) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849636 YP_001053733.1 CDS prlC NC_009053.1 1199892 1201925 R oligopeptidase A complement(1199892..1201925) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848772 YP_001053734.1 CDS pflA NC_009053.1 1202068 1202805 R activates pyruvate formate-lyase 1 under anaerobic conditions; pyruvate formate lyase-activating enzyme 1 complement(1202068..1202805) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849949 YP_001053735.1 CDS pflB NC_009053.1 1202932 1205244 R formate acetyltransferase complement(1202932..1205244) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848607 YP_001053736.1 CDS focA NC_009053.1 1205337 1206161 R formate transporter complement(1205337..1206161) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849565 YP_001053737.1 CDS APL_1038 NC_009053.1 1206365 1206847 D hypothetical protein 1206365..1206847 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848677 YP_001053738.1 CDS htpX NC_009053.1 1206907 1207776 R putative metalloprotease; heat shock protein HtpX complement(1206907..1207776) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850496 YP_001053739.1 CDS dinP NC_009053.1 1207863 1208933 R involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function; DNA polymerase IV complement(1207863..1208933) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848671 YP_001053740.1 CDS APL_1041 NC_009053.1 1209040 1209948 D hypothetical protein 1209040..1209948 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849256 YP_001053741.1 CDS menF NC_009053.1 1209987 1211267 R menaquinone-specific isochorismate synthase complement(1209987..1211267) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848673 YP_001053742.1 CDS APL_1043 NC_009053.1 1211431 1212648 D broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor; aminotransferase AlaT 1211431..1212648 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848497 YP_001053743.1 CDS APL_1044 NC_009053.1 1212692 1213585 D hypothetical protein 1212692..1213585 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850183 YP_001053744.1 CDS APL_1045 NC_009053.1 1213610 1214452 D hypothetical protein 1213610..1214452 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848675 YP_001053745.1 CDS APL_1046 NC_009053.1 1214449 1215066 D lysine exporter protein 1214449..1215066 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849107 YP_001053746.1 CDS hgbA NC_009053.1 1215147 1217993 R hemoglobin-binding protein A complement(1215147..1217993) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849777 YP_001053747.1 CDS hugZ NC_009053.1 1218053 1218574 R heme utilization protein complement(1218053..1218574) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850087 YP_001053748.1 CDS nrfX NC_009053.1 1219936 1220469 R disulfide bound formation protein DsbE complement(1219936..1220469) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848676 YP_001053749.1 CDS nrfE NC_009053.1 1220471 1222387 R cytochrome c-type biogenesis protein NrfE complement(1220471..1222387) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849065 YP_001053750.1 CDS kefBC NC_009053.1 1222558 1224423 R glutathione-regulated potassium-efflux system protein complement(1222558..1224423) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849469 YP_001053751.1 CDS cyaA NC_009053.1 1224512 1227040 R catalyzes transfer of adenylyl group of ATP from pyrophosphate to the 3'-hydroxyl group to form cyclic AMP; adenylate cyclase complement(1224512..1227040) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848674 YP_001053752.1 CDS fabB NC_009053.1 1227296 1228516 D FabB, beta-Ketoacyl-ACP synthase I, KASI; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-ACP synthase 1227296..1228516 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849232 YP_001053753.1 CDS APL_1056 NC_009053.1 1228708 1229016 D transposase 1228708..1229016 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848672 YP_001053754.1 CDS APL_1057 NC_009053.1 1229003 1229218 D transposase 1229003..1229218 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849844 YP_001053755.1 CDS APL_1058 NC_009053.1 1229230 1229565 D transposase 1229230..1229565 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849617 YP_001053756.1 CDS APL_1059 NC_009053.1 1229531 1230040 D transposase-like protein 1229531..1230040 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848685 YP_001053757.1 CDS APL_1060 NC_009053.1 1230187 1230534 D hypothetical protein 1230187..1230534 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848925 YP_001053758.1 CDS APL_1061 NC_009053.1 1230590 1231186 D hypothetical protein 1230590..1231186 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849916 YP_001053759.1 CDS APL_1062 NC_009053.1 1231227 1231601 D hypothetical protein 1231227..1231601 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848678 YP_001053760.1 CDS qseB NC_009053.1 1231690 1232355 D transcriptional regulatory protein QseB 1231690..1232355 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850302 YP_001053761.1 CDS qseC NC_009053.1 1232348 1233724 D sensor protein QseC 1232348..1233724 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848807 YP_001053762.1 CDS APL_1065 NC_009053.1 1233772 1234332 R hypothetical protein complement(1233772..1234332) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850256 YP_001053763.1 CDS yajC NC_009053.1 1234526 1234822 D member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex; preprotein translocase subunit YajC 1234526..1234822 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850259 YP_001053764.2 CDS secD NC_009053.1 1234849 1236696 D part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; preprotein translocase subunit SecD 1234849..1236696 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850482 YP_001053765.1 CDS secF NC_009053.1 1236707 1237681 D forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF; preprotein translocase subunit SecF 1236707..1237681 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850039 YP_001053766.1 CDS ftnA NC_009053.1 1237828 1238334 D ferritin-like protein 1 1237828..1238334 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849144 YP_001053767.1 CDS ftnB NC_009053.1 1238334 1238831 D ferritin-like protein 2 1238334..1238831 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849547 YP_001053768.1 CDS APL_1071 NC_009053.1 1239071 1240372 D hypothetical protein 1239071..1240372 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850538 YP_001053769.1 CDS APL_1072 NC_009053.1 1240429 1241019 R Maf-like protein complement(1240429..1241019) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850536 YP_001053770.1 CDS APL_1073 NC_009053.1 1241175 1241717 D hypothetical protein 1241175..1241717 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849114 YP_001053771.1 CDS thiI NC_009053.1 1241813 1243261 R Required for the synthesis of the thiazole moiety; thiamine biosynthesis protein ThiI complement(1241813..1243261) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849557 YP_001053772.1 CDS purA NC_009053.1 1243448 1244746 R catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis; adenylosuccinate synthetase complement(1243448..1244746) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850489 YP_001053773.1 CDS hflC NC_009053.1 1244933 1245820 R protein HflC complement(1244933..1245820) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850537 YP_001053774.1 CDS hflK NC_009053.1 1245823 1247013 R protein HflK complement(1245823..1247013) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848945 YP_001053775.1 CDS trxA NC_009053.1 1247188 1247505 R thioredoxin complement(1247188..1247505) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849716 YP_001053776.1 CDS APL_1079 NC_009053.1 1247641 1248933 R purine permease complement(1247641..1248933) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848848 YP_001053777.1 CDS metK NC_009053.1 1249095 1250246 R catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase; S-adenosylmethionine synthetase complement(1249095..1250246) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850527 YP_001053778.1 CDS APL_1081 NC_009053.1 1250466 1251359 D homocysteine/selenocysteine methylase 1250466..1251359 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849266 YP_001053779.1 CDS arcD NC_009053.1 1251451 1252866 D arginine/ornithine antiporter 1251451..1252866 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849750 YP_001053780.1 CDS arcD NC_009053.1 1252962 1254368 D arginine/ornithine antiporter 1252962..1254368 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849791 YP_001053781.1 CDS APL_1084 NC_009053.1 1254377 1255156 D hypothetical protein 1254377..1255156 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849537 YP_001053782.1 CDS argE NC_009053.1 1255171 1256313 D catalyzes the formation of L-ornithine from N(2)-acetyl-L-ornithine in arginine biosynthesis; acetylornithine deacetylase 1255171..1256313 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849223 YP_001053783.1 CDS ompW NC_009053.1 1256394 1257041 R outer membrane protein W complement(1256394..1257041) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848880 YP_001053784.1 CDS clpB NC_009053.1 1257302 1259875 D chaperone ClpB 1257302..1259875 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850133 YP_001053785.1 CDS APL_1088 NC_009053.1 1259932 1260933 R hypothetical protein complement(1259932..1260933) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849476 YP_001053786.1 CDS arsC NC_009053.1 1260945 1261349 R arsenate reductase complement(1260945..1261349) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850179 YP_001053787.1 CDS arsR NC_009053.1 1261409 1261723 R transcriptional regulator complement(1261409..1261723) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849422 YP_001053788.1 CDS aspA NC_009053.1 1261851 1263278 R catalyzes the formation of fumarate from aspartate; aspartate ammonia-lyase complement(1261851..1263278) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850000 YP_001053789.1 CDS APL_1092 NC_009053.1 1263419 1263700 R hypothetical protein complement(1263419..1263700) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849707 YP_001053790.1 CDS APL_1093 NC_009053.1 1263774 1264523 R hypothetical protein complement(1263774..1264523) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850159 YP_001053791.1 CDS APL_1094 NC_009053.1 1264888 1266276 D transcription regulator protein 1264888..1266276 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849371 YP_001053792.1 CDS purM NC_009053.1 1266330 1267367 R catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis; phosphoribosylaminoimidazole synthetase complement(1266330..1267367) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850427 YP_001053793.1 CDS APL_1096 NC_009053.1 1267582 1268715 D hypothetical protein 1267582..1268715 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849205 YP_001053794.1 CDS queC NC_009053.1 1268863 1269531 D queuosine biosynthesis protein QueC 1268863..1269531 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849631 YP_001053795.1 CDS APL_1098 NC_009053.1 1269524 1269946 D 6-pyruvoyl tetrahydrobiopterin synthase 1269524..1269946 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849527 YP_001053796.1 CDS APL_1099 NC_009053.1 1270039 1270671 D hypothetical protein 1270039..1270671 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849350 YP_001053797.1 CDS APL_1100 NC_009053.1 1270812 1271369 R hypothetical protein complement(1270812..1271369) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850049 YP_001053798.1 CDS pepA NC_009053.1 1272039 1273538 R catalyzes the removal of N-terminal amino acids preferably leucine from various peptides; leucyl aminopeptidase complement(1272039..1273538) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848868 YP_001053799.1 CDS APL_1102 NC_009053.1 1273906 1274721 D hypothetical protein 1273906..1274721 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850437 YP_001053800.1 CDS APL_1103 NC_009053.1 1274992 1276023 D hypothetical protein 1274992..1276023 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849226 YP_001053801.1 CDS APL_1104 NC_009053.1 1276024 1277106 D hypothetical protein 1276024..1277106 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848783 YP_001053802.1 CDS dnaE NC_009053.1 1277313 1280789 D catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase; DNA polymerase III subunit alpha 1277313..1280789 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850566 YP_001053803.1 CDS purT NC_009053.1 1281666 1282847 R non-folate utilizing enzyme, catalyzes the production of beta-formyl glycinamide ribonucleotide from formate, ATP, and beta-GAR and a side reaction producing acetyl phosphate and ADP from acetate and ATP; involved in de novo purine biosynthesis; phosphoribosylglycinamide formyltransferase 2 complement(1281666..1282847) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850260 YP_001053804.1 CDS plsB NC_009053.1 1282970 1285444 R PlsB; catalyzes the formation of 1-acyl-sn-glycerol 3-phosphate by transfering the acyl moiety from acyl-CoA; glycerol-3-phosphate acyltransferase complement(1282970..1285444) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849349 YP_001053805.1 CDS lexA NC_009053.1 1285601 1286233 D Represses a number of genes involved in the response to DNA damage; LexA repressor 1285601..1286233 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849212 YP_001053806.1 CDS mutH NC_009053.1 1286293 1286973 D MutH; Sequence-specific endonuclease that cleaves unmethylated GATC sequences during DNA repair; DNA mismatch repair protein 1286293..1286973 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849156 YP_001053807.1 CDS APL_1110 NC_009053.1 1287059 1287790 D hypothetical protein 1287059..1287790 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850561 YP_001053808.1 CDS nagZ NC_009053.1 1287905 1288942 D hydrolyzes the terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides; beta-hexosaminidase 1287905..1288942 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849180 YP_001053809.1 CDS rumB NC_009053.1 1289023 1290198 D RNA uridine methyltransferase B; catalyzes the formation of 5-methyl-uridine at position 747 in 23S rRNA; 23S rRNA methyluridine methyltransferase 1289023..1290198 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848460 YP_001053810.1 CDS eno NC_009053.1 1290405 1291715 D enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis; phosphopyruvate hydratase 1290405..1291715 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849738 YP_001053811.1 CDS APL_1114 NC_009053.1 1291740 1292420 D hypothetical protein 1291740..1292420 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849249 YP_001053812.1 CDS APL_1115 NC_009053.1 1292434 1292844 D hypothetical protein 1292434..1292844 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850029 YP_001053813.1 CDS recQ NC_009053.1 1292903 1294711 R ATP-dependent DNA helicase RecQ complement(1292903..1294711) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849458 YP_001053814.1 CDS cyaY NC_009053.1 1294796 1295101 R defects in the mitochondrial frataxin protein cause Friedreich ataxis which is an autosomal recessive neurodegenerative disease; based on phylogenomic distribution this protein may have a role in iron-sulfur cluster protein assembly; frataxin-like protein complement(1294796..1295101) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850559 YP_001053815.1 CDS gcp NC_009053.1 1295927 1296970 R in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity; DNA-binding/iron metalloprotein/AP endonuclease complement(1295927..1296970) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848639 YP_001053816.1 CDS APL_1121 NC_009053.1 1297062 1297838 R lipoprotein complement(1297062..1297838) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849816 YP_001053817.1 CDS rluD NC_009053.1 1297991 1298968 D responsible for synthesis of pseudouridine from uracil at positions 1911, 1915 and 1917 in 23S ribosomal RNA; 23S rRNA pseudouridine synthase D 1297991..1298968 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849280 YP_001053818.1 CDS APL_1123 NC_009053.1 1299012 1299725 R hypothetical protein complement(1299012..1299725) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850459 YP_001053819.1 CDS pfkA NC_009053.1 1299786 1300760 R catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis; 6-phosphofructokinase complement(1299786..1300760) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849861 YP_001053820.1 CDS APL_1125 NC_009053.1 1300870 1302072 R cysteine desulfurase complement(1300870..1302072) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848865 YP_001053821.1 CDS APL_1126 NC_009053.1 1302072 1302770 R micrococcal nuclease (thermonuclease)-like protein complement(1302072..1302770) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849195 YP_001053822.1 CDS APL_1127 NC_009053.1 1302836 1304203 R Na+/alanine symporter complement(1302836..1304203) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850110 YP_001053823.1 CDS APL_1128 NC_009053.1 1304670 1305722 R membrane protein complement(1304670..1305722) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850386 YP_001053824.1 CDS APL_1129 NC_009053.1 1305816 1306190 R hypothetical protein complement(1305816..1306190) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849999 YP_001053825.1 CDS APL_1130 NC_009053.1 1306339 1307736 D protease 1306339..1307736 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849878 YP_001053826.1 CDS APL_1131 NC_009053.1 1307881 1309230 D hypothetical protein 1307881..1309230 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849203 YP_001053827.1 CDS kdtA NC_009053.1 1309230 1310510 D catalyzes the transfer of 2-keto-3-deoxy-D-manno-octulosonic acid to lipid A; 3-deoxy-D-manno-octulosonic-acid transferase 1309230..1310510 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850395 YP_001053828.1 CDS coaD NC_009053.1 1310512 1310988 D Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA; phosphopantetheine adenylyltransferase 1310512..1310988 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849508 YP_001053829.1 CDS orn NC_009053.1 1310991 1311545 D 3'-5' exoribonuclease specific for small oligoribonuclotides; oligoribonuclease 1310991..1311545 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850534 YP_001053830.1 CDS APL_1135 NC_009053.1 1311553 1312044 D hypothetical protein 1311553..1312044 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850257 YP_001053831.1 CDS amiB NC_009053.1 1312068 1313213 D N-acetylmuramoyl-L-alanine amidase AmiB precursor 1312068..1313213 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848706 YP_001053832.1 CDS pgi NC_009053.1 1313292 1314932 R functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; glucose-6-phosphate isomerase complement(1313292..1314932) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849562 YP_001053833.1 CDS APL_1138 NC_009053.1 1314969 1315220 R hypothetical protein complement(1314969..1315220) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848670 YP_001053834.1 CDS aroE NC_009053.1 1316031 1316855 R AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate; shikimate 5-dehydrogenase complement(1316031..1316855) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849556 YP_001053835.1 CDS APL_1140 NC_009053.1 1316862 1317416 R hypothetical protein complement(1316862..1317416) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849072 YP_001053836.1 CDS APL_1141 NC_009053.1 1317939 1318247 R hypothetical protein complement(1317939..1318247) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848574 YP_001053837.1 CDS recX NC_009053.1 1318240 1318695 R binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities; recombination regulator RecX complement(1318240..1318695) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850002 YP_001053838.1 CDS recA NC_009053.1 1318766 1319896 R catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs; recombinase A complement(1318766..1319896) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848924 YP_001053839.1 CDS APL_1144 NC_009053.1 1320010 1320600 R hypothetical protein complement(1320010..1320600) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849658 YP_001053840.1 CDS pabB NC_009053.1 1320593 1321561 R catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine; para-aminobenzoate synthase component I complement(1320593..1321561) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849472 YP_001053841.1 CDS rmuC NC_009053.1 1321696 1323330 D DNA recombination protein RmuC-like protein 1321696..1323330 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848471 YP_001053842.1 CDS trpG NC_009053.1 1323314 1323898 D catalyzes the formation of anthranilate from chorismate and glutamine; functions in tryptophan biosynthesis; anthranilate synthase component II 1323314..1323898 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849035 YP_001053843.1 CDS APL_1148 NC_009053.1 1324003 1324452 D hypothetical protein 1324003..1324452 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848655 YP_001053844.1 CDS aspS NC_009053.1 1324625 1326400 D catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes; aspartyl-tRNA synthetase 1324625..1326400 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849850 YP_001053845.1 CDS ntpA NC_009053.1 1326434 1326904 D converts dATP to dAMP and pyrophosphate; dATP pyrophosphohydrolase 1326434..1326904 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849943 YP_001053846.1 CDS APL_1151 NC_009053.1 1326928 1327668 D hypothetical protein 1326928..1327668 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848794 YP_001053847.1 CDS APL_1152 NC_009053.1 1327802 1328326 D hypothetical protein 1327802..1328326 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848543 YP_001053848.1 CDS ruvC NC_009053.1 1328410 1328988 D endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity; Holliday junction resolvase 1328410..1328988 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848696 YP_001053849.1 CDS APL_1154 NC_009053.1 1329028 1330542 R zinc protease complement(1329028..1330542) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848894 YP_001053850.1 CDS metE NC_009053.1 1330700 1332973 R catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine; 5- methyltetrahydropteroyltriglutamate/homocysteine S-methyltransferase complement(1330700..1332973) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849095 YP_001053851.1 CDS metR NC_009053.1 1334889 1335818 D HTH-type transcriptional regulator MetR 1334889..1335818 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849502 YP_001053852.1 CDS APL_1159 NC_009053.1 1335896 1336777 R hypothetical protein complement(1335896..1336777) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848624 YP_001053853.1 CDS rluB NC_009053.1 1336910 1337959 R ribosomal large subunit pseudouridine synthase B complement(1336910..1337959) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849713 YP_001053854.1 CDS APL_1161 NC_009053.1 1338031 1338648 R hypothetical protein complement(1338031..1338648) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850104 YP_001053855.1 CDS APL_1162 NC_009053.1 1339192 1340088 R hypothetical protein complement(1339192..1340088) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849867 YP_001053856.1 CDS trpE NC_009053.1 1340248 1341798 D with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine; anthranilate synthase component I 1340248..1341798 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850422 YP_001053857.1 CDS trpG NC_009053.1 1341812 1342399 D TrpG; with TrpE catalyzes the formation of anthranilate and glutamate from chorismate and glutamine; TrpG provides the glutamine amidotransferase activity; anthranilate synthase component II 1341812..1342399 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849087 YP_001053858.1 CDS trpD NC_009053.1 1342456 1343460 D Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate; anthranilate phosphoribosyltransferase 1342456..1343460 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849521 YP_001053859.1 CDS APL_1166 NC_009053.1 1343503 1344258 D ubiquinone/menaquinone biosynthesis methyltransferase 1343503..1344258 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849563 YP_001053860.1 CDS APL_1167 NC_009053.1 1344285 1345370 R hypothetical protein complement(1344285..1345370) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848547 YP_001053861.1 CDS APL_1168 NC_009053.1 1345566 1345781 D hypothetical protein 1345566..1345781 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848499 YP_001053862.1 CDS rplI NC_009053.1 1345870 1346319 R in Escherichia coli this protein is wrapped around the base of the L1 stalk; 50S ribosomal protein L9 complement(1345870..1346319) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848741 YP_001053863.1 CDS priB NC_009053.1 1346539 1346913 R binds single-stranded DNA at the primosome assembly site; primosomal replication protein N complement(1346539..1346913) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849208 YP_001053864.1 CDS rpsF NC_009053.1 1346888 1347262 R binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21; 30S ribosomal protein S6 complement(1346888..1347262) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850541 YP_001053865.1 CDS purD NC_009053.1 1347552 1348838 D catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis; phosphoribosylamine--glycine ligase 1347552..1348838 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848787 YP_001053866.1 CDS pnuC NC_009053.1 1348930 1349622 R nicotinamide mononucleotide transporter complement(1348930..1349622) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849630 YP_001053867.1 CDS APL_1174 NC_009053.1 1349750 1350373 R hypothetical protein complement(1349750..1350373) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850398 YP_001053868.1 CDS hisS NC_009053.1 1350389 1351630 R catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG; histidyl-tRNA synthetase complement(1350389..1351630) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850132 YP_001053869.1 CDS ispG NC_009053.1 1351788 1352900 R catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase complement(1351788..1352900) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848995 YP_001053870.1 CDS APL_1177 NC_009053.1 1352910 1353878 R hypothetical protein complement(1352910..1353878) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850400 YP_001053871.1 CDS APL_1178 NC_009053.1 1354158 1355714 D integral membrane sulfate transporter 1354158..1355714 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850220 YP_001053872.1 CDS argH NC_009053.1 1356023 1357399 R catalyzes the formation of arginine from (N-L-arginino)succinate; argininosuccinate lyase complement(1356023..1357399) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849954 YP_001053873.1 CDS APL_1180 NC_009053.1 1357682 1358725 R oxidoreductase complement(1357682..1358725) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849293 YP_001053874.1 CDS kefB NC_009053.1 1358973 1360778 D glutathione-regulated potassium-efflux system protein 1358973..1360778 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849034 YP_001053875.1 CDS APL_1182 NC_009053.1 1360973 1362181 D hypothetical protein 1360973..1362181 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849079 YP_001053876.1 CDS APL_1183 NC_009053.1 1362278 1363678 D hypothetical protein 1362278..1363678 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849097 YP_001053877.1 CDS APL_1184 NC_009053.1 1363681 1364178 D hypothetical protein 1363681..1364178 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850057 YP_001053878.1 CDS APL_1185 NC_009053.1 1364192 1364836 D hypothetical protein 1364192..1364836 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850332 YP_001053879.1 CDS APL_1186 NC_009053.1 1365058 1365951 R transcriptional regulator complement(1365058..1365951) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848754 YP_001053880.1 CDS APL_1187 NC_009053.1 1366076 1366528 D hypothetical protein 1366076..1366528 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849360 YP_001053881.1 CDS APL_1188 NC_009053.1 1366651 1367283 R hypothetical protein complement(1366651..1367283) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849490 YP_001053882.1 CDS APL_1189 NC_009053.1 1367935 1368357 D hypothetical protein 1367935..1368357 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849491 YP_001053883.1 CDS APL_1190 NC_009053.1 1368533 1369432 R transcriptional regulator LysR-like protein complement(1368533..1369432) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849952 YP_001053884.1 CDS namA NC_009053.1 1369523 1370584 D NADPH dehydrogenase 1369523..1370584 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850349 YP_001053885.1 CDS APL_1192 NC_009053.1 1370654 1371703 D hypothetical protein 1370654..1371703 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849005 YP_001053886.1 CDS APL_1193 NC_009053.1 1371916 1373130 R type I restriction-modification system, S subunit complement(1371916..1373130) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850421 YP_001053887.1 CDS APL_1194 NC_009053.1 1373145 1374797 R type I restriction-modification system, M subunit complement(1373145..1374797) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849148 YP_001053888.1 CDS APL_1195 NC_009053.1 1374794 1376674 R hypothetical protein complement(1374794..1376674) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850035 YP_001053889.1 CDS APL_1196 NC_009053.1 1376676 1379810 R type I restriction enzyme, R subunit complement(1376676..1379810) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849306 YP_001053890.1 CDS APL_1197 NC_009053.1 1379926 1380792 R 3-hydroxyacid dehydrogenase complement(1379926..1380792) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849522 YP_001053891.1 CDS APL_1198 NC_009053.1 1381046 1381708 D NAD(P)H nitroreductase 1381046..1381708 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848834 YP_001053892.1 CDS APL_1199 NC_009053.1 1381862 1382479 D hypothetical protein 1381862..1382479 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849840 YP_001053893.1 CDS APL_1200 NC_009053.1 1382582 1383007 R DNA mismatch endonuclease complement(1382582..1383007) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849842 YP_001053894.1 CDS APL_1201 NC_009053.1 1383014 1384675 R hypothetical protein complement(1383014..1384675) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848666 YP_001053895.1 CDS APL_1202 NC_009053.1 1384691 1385785 R modification methylase complement(1384691..1385785) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849693 YP_001053896.1 CDS APL_1203 NC_009053.1 1386211 1386774 D hypothetical protein 1386211..1386774 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848742 YP_001053897.1 CDS APL_1204 NC_009053.1 1386848 1387705 R esterase complement(1386848..1387705) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849466 YP_001053898.1 CDS APL_1205 NC_009053.1 1387841 1388524 R glutathione S-transferase complement(1387841..1388524) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849588 YP_001053899.1 CDS APL_1206 NC_009053.1 1388658 1389077 R plasmid stability-like protein complement(1388658..1389077) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849939 YP_001053900.1 CDS APL_1207 NC_009053.1 1389087 1389344 R hypothetical protein complement(1389087..1389344) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848637 YP_001053901.1 CDS adhC NC_009053.1 1389494 1390612 R alcohol dehydrogenase class 3 complement(1389494..1390612) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850185 YP_001053902.1 CDS betT NC_009053.1 1390767 1392794 R choline-glycine betaine transporter complement(1390767..1392794) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850378 YP_001053903.1 CDS APL_1210 NC_009053.1 1393091 1393801 D hypothetical protein 1393091..1393801 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850155 YP_001053904.1 CDS APL_1211 NC_009053.1 1393801 1394637 D hypothetical protein 1393801..1394637 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849106 YP_001053905.1 CDS tehA NC_009053.1 1394716 1395663 R potassium-tellurite ethidium and proflavin transporter complement(1394716..1395663) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849430 YP_001053906.1 CDS APL_1213 NC_009053.1 1395762 1396412 R hypothetical protein complement(1395762..1396412) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848638 YP_001053907.1 CDS APL_1214 NC_009053.1 1396650 1397213 R hypothetical protein complement(1396650..1397213) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850198 YP_001053908.1 CDS APL_1215 NC_009053.1 1397300 1399144 R ABC transporter ATP-binding protein complement(1397300..1399144) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849642 YP_001053909.1 CDS luxS NC_009053.1 1399250 1399759 R catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2; S-ribosylhomocysteinase complement(1399250..1399759) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850390 YP_001053910.1 CDS APL_1217 NC_009053.1 1399814 1402480 R hypothetical protein complement(1399814..1402480) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849465 YP_001053911.1 CDS fur NC_009053.1 1402628 1403077 R ferric uptake regulation protein complement(1402628..1403077) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848648 YP_001053912.1 CDS fldA NC_009053.1 1403106 1403630 R An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin FldA complement(1403106..1403630) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850414 YP_001053913.1 CDS APL_1220 NC_009053.1 1403652 1403945 R LexA regulated protein complement(1403652..1403945) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848869 YP_001053914.1 CDS APL_1221 NC_009053.1 1404145 1404621 R hypothetical protein complement(1404145..1404621) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849209 YP_001053915.1 CDS APL_1222 NC_009053.1 1404705 1405706 D catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde; aspartate-semialdehyde dehydrogenase 1404705..1405706 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848720 YP_001053916.1 CDS APL_1223 NC_009053.1 1405767 1407062 D inner membrane protein 1405767..1407062 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849040 YP_001053917.1 CDS APL_1224 NC_009053.1 1407172 1407522 D hypothetical protein 1407172..1407522 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848779 YP_001053918.1 CDS APL_1227 NC_009053.1 1408957 1409745 D hypothetical protein 1408957..1409745 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849721 YP_001053919.1 CDS infA NC_009053.1 1409885 1410103 R stimulates the activities of the other two initiation factors, IF-2 and IF-3; translation initiation factor IF-1 complement(1409885..1410103) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848564 YP_001053920.1 CDS aphA NC_009053.1 1410195 1410857 R AphA-like protein complement(1410195..1410857) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850329 YP_001053921.1 CDS serB NC_009053.1 1410957 1411817 D phosphoserine phosphatase 1410957..1411817 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849887 YP_001053922.1 CDS APL_1231 NC_009053.1 1411876 1412367 D putative nucleotide binding property based on structural studies of Haemophilus influenzae crystallized protein in PDB Accession Number 1IN0 and NMR studies of Escherichia coli YajQ; the YajQ protein from Pseudomonas synringae appears to play a role in activation of bateriophage phi6 segment L transcription; nucleotide-binding protein 1411876..1412367 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850480 YP_001053923.1 CDS malP NC_009053.1 1412721 1415120 D maltodextrin phosphorylase 1412721..1415120 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849754 YP_001053924.1 CDS malT NC_009053.1 1415184 1417901 R HTH-type transcriptional regulator MalT complement(1415184..1417901) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849638 YP_001053925.1 CDS APL_1234 NC_009053.1 1418016 1418900 R maltose regulon periplasmic protein complement(1418016..1418900) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849331 YP_001053926.1 CDS lamB NC_009053.1 1418968 1420242 R porin involved in the transport of maltose and maltodextrins; maltoporin complement(1418968..1420242) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849936 YP_001053927.1 CDS malK NC_009053.1 1420312 1421451 R with malEFG is involved in import of maltose/maltodextrin; maltose/maltodextrin transporter ATP-binding protein complement(1420312..1421451) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850405 YP_001053928.1 CDS malE NC_009053.1 1421783 1422967 D functions in the MalKFGE ABC transporter complex to transport maltose into the cell by using ATP hydrolysis; maltose ABC transporter periplasmic protein 1421783..1422967 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849018 YP_001053929.1 CDS malF NC_009053.1 1423046 1424596 D with MalKGE is involved in maltose transport into the cell; maltose transporter membrane protein 1423046..1424596 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850103 YP_001053930.1 CDS malG NC_009053.1 1424647 1425537 D with MalKFE is involved in the transport of maltose into the cell; maltose transporter permease 1424647..1425537 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849316 YP_001053931.1 CDS malQ NC_009053.1 1425628 1427646 D amylomaltase; acts to release glucose from maltodextrins; 4-alpha-glucanotransferase 1425628..1427646 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849684 YP_001053932.1 CDS APL_1241 NC_009053.1 1427864 1429450 D hypothetical protein 1427864..1429450 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850492 YP_001053933.1 CDS APL_1242 NC_009053.1 1429516 1430310 D deoxyribonuclease 1429516..1430310 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848743 YP_001053934.1 CDS gor NC_009053.1 1430369 1431739 R catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels of reduced glutathione in the cytosol; involved in redox regulation and oxidative defense; glutathione reductase complement(1430369..1431739) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850290 YP_001053935.1 CDS APL_1244 NC_009053.1 1432223 1432834 D hypothetical protein 1432223..1432834 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849647 YP_001053936.1 CDS APL_1245 NC_009053.1 1432923 1433441 R hypothetical protein complement(1432923..1433441) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849086 YP_001053937.1 CDS APL_1246 NC_009053.1 1433543 1434181 R hypothetical protein complement(1433543..1434181) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848993 YP_001053938.1 CDS APL_1247 NC_009053.1 1434344 1434637 R hypothetical protein complement(1434344..1434637) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850010 YP_001053939.1 CDS APL_1248 NC_009053.1 1434637 1435296 R AzlC family protein complement(1434637..1435296) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848542 YP_001053940.1 CDS sapF NC_009053.1 1435370 1436170 R peptide transport system ATP-binding protein SapF complement(1435370..1436170) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849165 YP_001053941.1 CDS fba NC_009053.1 1436286 1437362 R catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate; fructose-bisphosphate aldolase complement(1436286..1437362) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849625 YP_001053942.1 CDS pgk NC_009053.1 1437463 1438638 R Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; phosphoglycerate kinase complement(1437463..1438638) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849213 YP_001053943.1 CDS APL_1252 NC_009053.1 1438796 1440184 R hypothetical protein complement(1438796..1440184) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848866 YP_001053944.1 CDS APL_1253 NC_009053.1 1440415 1441689 R sodium/sulfate transporter complement(1440415..1441689) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849583 YP_001053945.1 CDS APL_1254 NC_009053.1 1441994 1443385 R hypothetical protein complement(1441994..1443385) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849820 YP_001053946.1 CDS parE NC_009053.1 1443581 1445494 R decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit B complement(1443581..1445494) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848979 YP_001053947.1 CDS phoR NC_009053.1 1445572 1446864 R phosphate regulon sensor protein PhoR complement(1445572..1446864) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848760 YP_001053948.1 CDS phoB NC_009053.1 1446864 1447505 R phosphate regulon transcriptional regulatory protein PhoB complement(1446864..1447505) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849784 YP_001053949.1 CDS pstB NC_009053.1 1447685 1448464 R ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate transporter ATP-binding protein complement(1447685..1448464) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848884 YP_001053950.1 CDS pstA NC_009053.1 1448473 1449324 R phosphate transport system permease protein PstA complement(1448473..1449324) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849139 YP_001053951.1 CDS pstC NC_009053.1 1449324 1450277 R phosphate transport system permease protein PstC complement(1449324..1450277) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849351 YP_001053952.1 CDS pstS NC_009053.1 1450428 1451471 R phosphate-binding periplasmic protein complement(1450428..1451471) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849321 YP_001053953.1 CDS APL_1262 NC_009053.1 1451604 1451990 R MerR family transcriptional regulator complement(1451604..1451990) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850441 YP_001053954.1 CDS APL_1263 NC_009053.1 1452076 1452528 D hypothetical protein 1452076..1452528 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849953 YP_001053955.1 CDS APL_1264 NC_009053.1 1452546 1452746 D cation transport ATPase 1452546..1452746 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849219 YP_001053956.1 CDS copA NC_009053.1 1452985 1455135 D copper-transporting P-type ATPase 1452985..1455135 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850188 YP_001053957.1 CDS APL_1266 NC_009053.1 1455233 1456054 R dehydrogenase complement(1455233..1456054) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849375 YP_001053958.1 CDS APL_1267 NC_009053.1 1456082 1456657 R hypothetical protein complement(1456082..1456657) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849285 YP_001053959.1 CDS sppA NC_009053.1 1456773 1458629 D protease 4 1456773..1458629 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849651 YP_001053960.1 CDS APL_1269 NC_009053.1 1458764 1459531 D ribonuclease 1458764..1459531 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848521 YP_001053961.1 CDS sprT NC_009053.1 1459562 1460053 D hypothetical protein 1459562..1460053 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849672 YP_001053962.1 CDS ndh NC_009053.1 1460158 1461444 D NADH dehydrogenase 1460158..1461444 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849539 YP_001053963.1 CDS APL_1272 NC_009053.1 1461636 1463975 R transcriptional accessory protein complement(1461636..1463975) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849222 YP_001053964.1 CDS APL_1273 NC_009053.1 1464050 1464598 R fimbrial biogenesis and twitching motility protein PilF-like protein complement(1464050..1464598) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849364 YP_001053965.1 CDS APL_1274 NC_009053.1 1464652 1465833 R 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance; ribosomal RNA large subunit methyltransferase N complement(1464652..1465833) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850169 YP_001053966.1 CDS gltX NC_009053.1 1466737 1468176 D Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation; glutamyl-tRNA synthetase 1466737..1468176 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849358 YP_001053967.1 CDS APL_1276 NC_009053.1 1468514 1468765 D Antitoxin that counteracts the effect of the YoeB toxin; antitoxin YefM 1468514..1468765 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849757 YP_001053968.1 CDS APL_1277 NC_009053.1 1469179 1469346 R hypothetical protein complement(1469179..1469346) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849171 YP_001053969.1 CDS lpxK NC_009053.1 1469348 1470328 R transfers the gamma-phosphate of ATP to the 4' position of a tetraacyldisaccharide 1-phosphate intermediate to form tetraacyldisaccharide 1,4'-bis-phosphate; tetraacyldisaccharide 4'-kinase complement(1469348..1470328) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848849 YP_001053970.1 CDS clpX NC_009053.1 1470422 1471681 R binds and unfolds substrates as part of the ClpXP protease; ATP-dependent protease ATP-binding subunit ClpX complement(1470422..1471681) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849329 YP_001053971.1 CDS clpP NC_009053.1 1471681 1472271 R hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit complement(1471681..1472271) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849909 YP_001053972.1 CDS APL_1281 NC_009053.1 1472393 1472785 D hypothetical protein 1472393..1472785 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850488 YP_001053973.1 CDS dnaQ NC_009053.1 1473144 1473917 R DNA polymerase III subunit epsilon complement(1473144..1473917) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850481 YP_001053974.1 CDS APL_1283 NC_009053.1 1474004 1475674 R ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence; ABC transporter ATP-binding protein complement(1474004..1475674) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848861 YP_001053975.1 CDS APL_1284 NC_009053.1 1475839 1476177 D DNA-binding protein 1475839..1476177 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849906 YP_001053976.1 CDS APL_1285 NC_009053.1 1476170 1476538 D hypothetical protein 1476170..1476538 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848709 YP_001053977.1 CDS murA NC_009053.1 1477025 1478299 R adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase complement(1477025..1478299) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850469 YP_001053978.1 CDS APL_1287 NC_009053.1 1478431 1478691 R hypothetical protein complement(1478431..1478691) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848803 YP_001053979.1 CDS APL_1288 NC_009053.1 1478704 1479057 R hypothetical protein complement(1478704..1479057) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848651 YP_001053980.1 CDS APL_1289 NC_009053.1 1479067 1479705 R hypothetical protein complement(1479067..1479705) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849237 YP_001053981.1 CDS APL_1290 NC_009053.1 1479783 1480310 R hypothetical protein complement(1479783..1480310) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849248 YP_001053982.1 CDS APL_1291 NC_009053.1 1480329 1481033 R hypothetical protein complement(1480329..1481033) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850474 YP_001053983.1 CDS APL_1292 NC_009053.1 1481098 1481901 R ABC transporter ATP-binding protein complement(1481098..1481901) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849921 YP_001053984.1 CDS htrA NC_009053.1 1482162 1483556 D periplasmic serine protease do/hhoA-like precursor 1482162..1483556 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848722 YP_001053985.1 CDS APL_1294 NC_009053.1 1483595 1484482 R hypothetical protein complement(1483595..1484482) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850365 YP_001053986.1 CDS argR NC_009053.1 1484482 1484943 R regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes; arginine repressor complement(1484482..1484943) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849304 YP_001053987.1 CDS mdh NC_009053.1 1485137 1486090 D oxidizes malate to oxaloacetate; malate dehydrogenase 1485137..1486090 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850462 YP_001053988.1 CDS APL_1297 NC_009053.1 1486180 1486449 D hypothetical protein 1486180..1486449 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850268 YP_001053989.1 CDS adk NC_009053.1 1486517 1487161 R essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP; adenylate kinase complement(1486517..1487161) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849685 YP_001053990.1 CDS APL_1299 NC_009053.1 1487313 1489436 R TonB dependent/ligand-gated channel complement(1487313..1489436) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849119 YP_001053991.1 CDS APL_1300 NC_009053.1 1489613 1490893 R hypothetical protein complement(1489613..1490893) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849770 YP_001053992.1 CDS galE NC_009053.1 1491032 1492048 R UDP-glucose 4-epimerase complement(1491032..1492048) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850058 YP_001053993.1 CDS ligA NC_009053.1 1492112 1494163 R this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB; NAD-dependent DNA ligase LigA complement(1492112..1494163) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849676 YP_001053994.1 CDS zipA NC_009053.1 1494227 1495237 R interacts with cell division protein FitsZ and may be required to anchor septal ring structure; cell division protein ZipA complement(1494227..1495237) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849591 YP_001053995.1 CDS cysZ NC_009053.1 1495357 1496238 D putative role in sulfur assimilation; sulfate transport protein CysZ 1495357..1496238 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850451 YP_001053996.1 CDS gnd NC_009053.1 1496719 1498173 R catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate; 6-phosphogluconate dehydrogenase complement(1496719..1498173) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849467 YP_001053997.1 CDS APL_1306 NC_009053.1 1498244 1498696 R hypothetical protein complement(1498244..1498696) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849413 YP_001053998.1 CDS APL_1309 NC_009053.1 1499927 1501249 R permease complement(1499927..1501249) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849801 YP_001053999.1 CDS pgl NC_009053.1 1501382 1502080 R 6-phosphogluconolactonase complement(1501382..1502080) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850258 YP_001054000.1 CDS zwf NC_009053.1 1502152 1503639 R catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate; glucose-6-phosphate 1-dehydrogenase complement(1502152..1503639) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849468 YP_001054001.1 CDS cysQ NC_009053.1 1503711 1504526 R CysQ-like protein complement(1503711..1504526) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849833 YP_001054002.1 CDS nudE NC_009053.1 1504539 1505096 R ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose; ADP-ribose diphosphatase NudE complement(1504539..1505096) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848464 YP_001054003.1 CDS hslR NC_009053.1 1505239 1505643 D heat shock-like protein 15 1505239..1505643 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850340 YP_001054004.1 CDS hslO NC_009053.1 1505774 1506664 D becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers; Hsp33-like chaperonin 1505774..1506664 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849060 YP_001054005.1 CDS dcuB2 NC_009053.1 1506732 1508066 R functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to DcuA; DcuA and DcuB function as independent and mutually redundant C4-dicarboxylate (aspartate, malate, fumarate and succinate) transporters; anaerobic C4-dicarboxylate transporter complement(1506732..1508066) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849204 YP_001054006.1 CDS arcB NC_009053.1 1508919 1509923 D ornithine carbamoyltransferase 1508919..1509923 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849194 YP_001054007.1 CDS arcC NC_009053.1 1509945 1510892 D reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP; carbamate kinase 1509945..1510892 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849769 YP_001054008.1 CDS ptsB NC_009053.1 1511140 1512561 R Includes: Sucrose-specific phosphotransferase enzyme IIB component; Sucrose permease IIC component; PTS system sucrose-specific transporter subunit IIBC complement(1511140..1512561) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848682 YP_001054009.1 CDS thiQ NC_009053.1 1512752 1513396 R thiamine transport ATP-binding protein ThiQ complement(1512752..1513396) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849884 YP_001054010.1 CDS thiP NC_009053.1 1513393 1515018 R permease; with TbpA and ThiQ functions in transport of thiamine and thiamine pyrophosphate into the cell; repressed in presence of exogenous thiamine; thiamine transporter membrane protein complement(1513393..1515018) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848892 YP_001054011.1 CDS ptsH NC_009053.1 1515255 1515512 D PTS system phosphocarrier protein HPr 1515255..1515512 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848616 YP_001054012.1 CDS ptsI NC_009053.1 1515636 1517357 D Phosphotransferase system, enzyme I; transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein; part of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active-transport system; phosphoenolpyruvate-protein phosphotransferase 1515636..1517357 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850041 YP_001054013.1 CDS crr NC_009053.1 1517442 1517942 D functions in phosphoenolpyruvate-(PEP)-dependent phosphotransferase (PTS) system; functions in the transport and phosphorylation of glucose; PTS system glucose-specific transporter 1517442..1517942 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848523 YP_001054014.1 CDS APL_1325 NC_009053.1 1518127 1519554 D catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A); (dimethylallyl)adenosine tRNA methylthiotransferase 1518127..1519554 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850295 YP_001054015.1 CDS uvrD NC_009053.1 1519784 1521982 D unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present; involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair.; DNA-dependent helicase II 1519784..1521982 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850442 YP_001054016.1 CDS hypB NC_009053.1 1522186 1522995 D GTP hydrolase involved in nickel liganding into hydrogenases; hydrogenase nickel incorporation protein HypB 1522186..1522995 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850355 YP_001054017.1 CDS hypD NC_009053.1 1523007 1524122 D hydrogenase expression/formation protein HypD 1523007..1524122 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849730 YP_001054018.1 CDS hypE NC_009053.1 1524124 1525137 D hydrogenase isoenzymes formation protein HypE 1524124..1525137 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849877 YP_001054019.1 CDS hypF NC_009053.1 1525217 1527502 R carbamoyltransferase HypF complement(1525217..1527502) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848518 YP_001054020.1 CDS hyaA NC_009053.1 1527737 1528879 D involved in hydrogen uptake; hydrogenase 2 small subunit 1527737..1528879 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850165 YP_001054021.1 CDS hybA NC_009053.1 1528872 1529909 D Fe-S ferrodoxin type component; participates in the periplasmic electron-transferring activity of hydrogenase 2; hydrogenase 2 protein HybA 1528872..1529909 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849879 YP_001054022.1 CDS hybB NC_009053.1 1529902 1531083 D HybB; cytochrome b subunit of the hydrogenase 2 enzyme, composed of HybA, B, C, and O subunits; hydrogenase 2 b cytochrome subunit 1529902..1531083 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849386 YP_001054023.1 CDS hyaB NC_009053.1 1531080 1532789 D involved in hydrogen uptake; hydrogenase 2 large subunit 1531080..1532789 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849682 YP_001054024.1 CDS hybD NC_009053.1 1532789 1533286 D protease responsible for the cleavage of a 15 amino acid peptide from the C-terminal end of the large subunit of hydrogenase 2 (HybC); hydrogenase 2 maturation endopeptidase 1532789..1533286 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849231 YP_001054025.1 CDS hybE NC_009053.1 1533279 1533782 D hydrogenase 2-specific chaperone 1533279..1533782 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848718 YP_001054026.1 CDS hybG NC_009053.1 1533810 1534088 D hydrogenase 2 accessory protein HypG 1533810..1534088 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850033 YP_001054027.1 CDS hybF NC_009053.1 1534183 1534524 R hydrogenase nickel incorporation protein HybF complement(1534183..1534524) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849033 YP_001054028.1 CDS mfd NC_009053.1 1535447 1538896 R transcription-repair coupling factor complement(1535447..1538896) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849083 YP_001054029.1 CDS pepN NC_009053.1 1538998 1541607 D aminopeptidase N 1538998..1541607 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850410 YP_001054030.1 CDS APL_1341 NC_009053.1 1541745 1542335 R involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsX; glycerol-3-phosphate acyltransferase PlsY complement(1541745..1542335) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849871 YP_001054031.1 CDS folB NC_009053.1 1542407 1542760 D dihydroneopterin aldolase 1542407..1542760 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849872 YP_001054032.1 CDS cdd NC_009053.1 1542869 1543762 D Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis; cytidine deaminase 1542869..1543762 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848536 YP_001054033.1 CDS ftsX NC_009053.1 1543809 1544747 R putative ABC transporter, membrane protein; cell division protein FtsX complement(1543809..1544747) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848568 YP_001054034.1 CDS fstE NC_009053.1 1544757 1545410 R cell division ATP-binding protein FtsE complement(1544757..1545410) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849886 YP_001054035.1 CDS ftsY NC_009053.1 1545501 1547234 R cell division protein FtsY complement(1545501..1547234) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849585 YP_001054036.1 CDS APL_1347 NC_009053.1 1547312 1547905 D methylase 1547312..1547905 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850022 YP_001054037.1 CDS APL_1348 NC_009053.1 1547971 1548282 D highly acidic protein; the structure of the Haemophilus influenzae protein shows similarity to uracil DNA glycosylase inhibitor (Ugi); binds heat-unstable protein (HU-alpha) which is a histone-like protein; dsDNA-mimic protein 1547971..1548282 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850449 YP_001054038.1 CDS hpaC NC_009053.1 1548298 1548810 D 4-hydroxyphenylacetic acid hydroxylase 1548298..1548810 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849417 YP_001054039.1 CDS tehB NC_009053.1 1548925 1549797 D with TehA confers resistance to tellurite; tellurite resistance protein TehB 1548925..1549797 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849418 YP_001054040.1 CDS artM NC_009053.1 1549925 1550608 R with ArtPQJI acts to transport arginine across the inner membrane; arginine transporter permease subunit ArtM complement(1549925..1550608) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850417 YP_001054041.1 CDS artQ NC_009053.1 1550608 1551279 R with ArtPMJI transports arginine across the inner membrane; arginine transporter permease subunit ArtQ complement(1550608..1551279) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849758 YP_001054042.1 CDS artI NC_009053.1 1551285 1552004 R arginine-binding periplasmic protein complement(1551285..1552004) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849504 YP_001054043.1 CDS artP NC_009053.1 1552024 1552758 R With ArtMQJI transports arginine across the inner membrane; arginine transporter ATP-binding subunit complement(1552024..1552758) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850162 YP_001054044.1 CDS APL_1355 NC_009053.1 1552983 1553480 R hypothetical protein complement(1552983..1553480) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850015 YP_001054045.1 CDS APL_1356 NC_009053.1 1553553 1554515 D sodium/calcium exchange protein 1553553..1554515 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850416 YP_001054046.1 CDS APL_1357 NC_009053.1 1554593 1554886 R HTH-type transcriptional regulator complement(1554593..1554886) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850500 YP_001054047.1 CDS APL_1358 NC_009053.1 1554867 1555238 R hypothetical protein complement(1554867..1555238) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850501 YP_001054048.1 CDS dipZ NC_009053.1 1555432 1557183 D two electrons are transferred from cytoplasmic NADPH to thioredoxin and then to the inner membrane protein DsbD which keeps the disulfide isomerase DsbC in a reduced state in the oxidizing periplasm; DsbC in turns rearranges incorrectly made disulfide bonds in the periplasm; thiol:disulfide interchange protein 1555432..1557183 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849875 YP_001054049.1 CDS APL_1360 NC_009053.1 1557241 1557810 D hypothetical protein 1557241..1557810 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850555 YP_001054050.1 CDS APL_1361 NC_009053.1 1557854 1558708 R hypothetical protein complement(1557854..1558708) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848811 YP_001054051.1 CDS APL_1362 NC_009053.1 1558781 1560529 D hypothetical protein 1558781..1560529 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848800 YP_001054052.1 CDS APL_1363 NC_009053.1 1560504 1560875 D hypothetical protein 1560504..1560875 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850163 YP_001054053.1 CDS gmhA NC_009053.1 1560884 1561462 D phosphoheptose isomerase 1560884..1561462 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850556 YP_001054054.1 CDS hly NC_009053.1 1561484 1562071 D pubmed:8461417; hypothetical protein 1561484..1562071 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849618 YP_001054055.1 CDS APL_1366 NC_009053.1 1562283 1563650 R YfhD; uncharacterized member of the transglycosylase slt family; part of the rob operon, which plays a role in cellular resistance to antibiotics, bactericidal agents, and organic solvents; unknown function; transglycosylase complement(1562283..1563650) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849619 YP_001054056.1 CDS ccmF NC_009053.1 1564521 1566470 R cytochrome c-type biogenesis protein CcmF complement(1564521..1566470) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849019 YP_001054057.1 CDS ccmE NC_009053.1 1566470 1567015 R CycJ; periplasmic heme chaperone that binds heme transiently via a histidine residue and delivers it to newly synthesized and exported c-type cytochromes; requires the ATP hydrolysis activity of the CcmA protein in order to transfer the heme to the apocytochrome; part of the cytochrome c maturation system; periplasmic protein anchored to the inner membrane; cytochrome c-type biogenesis protein CcmE complement(1566470..1567015) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850381 YP_001054058.1 CDS ccmD NC_009053.1 1567199 1567396 R heme exporter protein D complement(1567199..1567396) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850524 YP_001054059.1 CDS ccmC NC_009053.1 1567409 1568140 R heme exporter protein C complement(1567409..1568140) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848862 YP_001054060.1 CDS ccmB NC_009053.1 1568191 1568853 R heme exporter protein B complement(1568191..1568853) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849990 YP_001054061.1 CDS ccmA NC_009053.1 1568850 1569485 R ATP-binding protein; required for proper cytochrome c maturation; cytochrome c biogenesis protein CcmA complement(1568850..1569485) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850250 YP_001054062.1 CDS APL_1373 NC_009053.1 1569626 1570336 R controls initiation of DNA replication by inhibiting re-initiation of replication, promotes hydrolysis of DnaA-bound ATP; DNA replication initiation factor complement(1569626..1570336) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849253 YP_001054063.1 CDS APL_1374 NC_009053.1 1576322 1577155 D hypothetical protein 1576322..1577155 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850498 YP_001054064.1 CDS oadG NC_009053.1 1577337 1577594 D catalyzes the decarboxylation of oxaloacetate to form pyruvate and carbon dioxide; oxaloacetate decarboxylase subunit gamma 1577337..1577594 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849424 YP_001054065.1 CDS oadA NC_009053.1 1577610 1579418 D catalyzes the formation of pyruvate from oxaloacetate; oxaloacetate decarboxylase 1577610..1579418 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850189 YP_001054066.1 CDS oadB NC_009053.1 1579435 1580739 D oxaloacetate decarboxylase subunit beta 1579435..1580739 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850139 YP_001054067.1 CDS phnA NC_009053.1 1580872 1581195 D alkylphosphonate uptake protein 1580872..1581195 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849084 YP_001054068.1 CDS ccp NC_009053.1 1581367 1582767 D cytochrome c peroxidase 1581367..1582767 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849036 YP_001054069.1 CDS APL_1380 NC_009053.1 1582833 1583126 R hypothetical protein complement(1582833..1583126) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849305 YP_001054070.1 CDS APL_1381 NC_009053.1 1583128 1583661 R hypothetical protein complement(1583128..1583661) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850261 YP_001054071.1 CDS APL_1382 NC_009053.1 1583783 1584124 R hypothetical protein complement(1583783..1584124) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850186 YP_001054072.1 CDS trmB NC_009053.1 1584180 1584932 R tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine; tRNA (guanine-N(7)-)-methyltransferase complement(1584180..1584932) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850187 YP_001054073.1 CDS fabH NC_009053.1 1584980 1585930 R FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs; 3-oxoacyl-ACP synthase complement(1584980..1585930) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848572 YP_001054074.1 CDS plsX NC_009053.1 1585942 1586976 R involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY; glycerol-3-phosphate acyltransferase PlsX complement(1585942..1586976) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849428 YP_001054075.1 CDS rpmF NC_009053.1 1587001 1587171 R some L32 proteins have zinc finger motifs consisting of CXXC while others do not; 50S ribosomal protein L32 complement(1587001..1587171) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850127 YP_001054076.1 CDS APL_1387 NC_009053.1 1587189 1587716 R hypothetical protein complement(1587189..1587716) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850529 YP_001054077.1 CDS APL_1388 NC_009053.1 1587936 1588727 D ABC transporter permease 1587936..1588727 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849660 YP_001054078.1 CDS APL_1389 NC_009053.1 1588913 1590085 D hypothetical protein 1588913..1590085 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849835 YP_001054079.1 CDS APL_1390 NC_009053.1 1590464 1591978 D sodium-dependent transporter 1590464..1591978 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850434 YP_001054080.1 CDS APL_1391 NC_009053.1 1592366 1593337 D Includes: Mannose-specific phosphotransferase enzyme IIA component; Mannose-specific phosphotransferase enzyme IIB component; PTS system mannose-specific transporter subunit IIAB 1592366..1593337 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850435 YP_001054081.1 CDS ptnC NC_009053.1 1593350 1594150 D mannose permease IIC component 1593350..1594150 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850313 YP_001054082.1 CDS ptnD NC_009053.1 1594164 1595000 D hosphoenolpyruvate-dependent sugar phosphotransferase system catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IID with IIC forms the translocation channel; PTS system mannose-specific transporter subunit IID 1594164..1595000 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849514 YP_001054083.1 CDS APL_1394 NC_009053.1 1595099 1595557 D hypothetical protein 1595099..1595557 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850317 YP_001054084.1 CDS manA NC_009053.1 1595554 1596759 D mannose-6-phosphate isomerase 1595554..1596759 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850440 YP_001054085.1 CDS APL_1396 NC_009053.1 1596821 1597336 D hypothetical protein 1596821..1597336 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849392 YP_001054086.1 CDS APL_1397 NC_009053.1 1597474 1598262 R hypothetical protein complement(1597474..1598262) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850068 YP_001054087.1 CDS tufB NC_009053.1 1598554 1599738 R EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu complement(1598554..1599738) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850108 YP_001054088.1 CDS fusA NC_009053.1 1599800 1601905 R EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G complement(1599800..1601905) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850109 YP_001054089.1 CDS rpsG NC_009053.1 1602005 1602475 R binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit; 30S ribosomal protein S7 complement(1602005..1602475) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849915 YP_001054090.1 CDS rpsL NC_009053.1 1602612 1602986 R interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance; 30S ribosomal protein S12 complement(1602612..1602986) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849900 YP_001054091.1 CDS rfaC NC_009053.1 1603108 1604067 R ADP-heptose--LPS heptosyltransferase complement(1603108..1604067) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850499 YP_001054092.1 CDS rfaF NC_009053.1 1604143 1605180 R ADP-heptose--LPS heptosyltransferase complement(1604143..1605180) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850170 YP_001054093.1 CDS oapB NC_009053.1 1605262 1605666 R opacity associated protein B complement(1605262..1605666) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850393 YP_001054094.1 CDS oapA NC_009053.1 1605788 1607179 R opacity associated protein A complement(1605788..1607179) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848876 YP_001054095.1 CDS comEA NC_009053.1 1607480 1607824 D DNA uptake protein 1607480..1607824 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849558 YP_001054096.1 CDS psd NC_009053.1 1607975 1608868 D catalyzes the decarboxylation of phosphatidyl-L-serine to phosphatidylethanoleamine; phosphatidylserine decarboxylase 1607975..1608868 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849559 YP_001054097.1 CDS gshA NC_009053.1 1609024 1611297 D Synthesizes glutathione from L-glutamate and L-cysteine via gamma-L-glutamyl-L-cysteine; bifunctional glutamate--cysteine ligase/glutathione synthetase 1609024..1611297 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848463 YP_001054098.1 CDS APL_1409 NC_009053.1 1611389 1612009 R CueR-like transcriptional regulator complement(1611389..1612009) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850048 YP_001054099.1 CDS tnaB NC_009053.1 1612209 1613411 D ttryptophan-specific transport protein 1612209..1613411 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850161 YP_001054100.1 CDS APL_1411 NC_009053.1 1613475 1613768 R hypothetical protein complement(1613475..1613768) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849501 YP_001054101.1 CDS APL_1412 NC_009053.1 1613908 1614810 D oxidoreductase 1613908..1614810 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849606 YP_001054102.1 CDS APL_1413 NC_009053.1 1614873 1616648 R long-chain-fatty-acid--CoA ligase complement(1614873..1616648) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848649 YP_001054103.1 CDS mqo NC_009053.1 1616829 1618304 R malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate; malate:quinone oxidoreductase complement(1616829..1618304) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850549 YP_001054104.1 CDS APL_1415 NC_009053.1 1618412 1618825 R hypothetical protein complement(1618412..1618825) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850550 YP_001054105.1 CDS APL_1416 NC_009053.1 1619045 1619386 D hypothetical protein 1619045..1619386 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848548 YP_001054106.1 CDS APL_1417 NC_009053.1 1619428 1619853 D hypothetical protein 1619428..1619853 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848870 YP_001054107.1 CDS mglC NC_009053.1 1619924 1620934 R ABC transporter; functions in galactose transport; part of MglA2C2B transporter complex; beta-methylgalactoside transporter inner membrane protein complement(1619924..1620934) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849553 YP_001054108.1 CDS mglA NC_009053.1 1620951 1622450 R with MglBC transports galactose or methyl galactoside into the cell; contains 2 ATP binding domains; galactose/methyl galaxtoside transporter ATP-binding protein complement(1620951..1622450) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849247 YP_001054109.1 CDS mglB NC_009053.1 1622513 1623505 R D-galactose-binding periplasmic protein complement(1622513..1623505) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850497 YP_001054110.1 CDS ompA NC_009053.1 1623759 1624865 R outer membrane protein P5 complement(1623759..1624865) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850046 YP_001054111.1 CDS APL_1422 NC_009053.1 1625293 1628382 D hypothetical protein 1625293..1628382 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848874 YP_001054112.1 CDS APL_1423 NC_009053.1 1628515 1628940 D hypothetical protein 1628515..1628940 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848875 YP_001054113.1 CDS oxaA NC_009053.1 1629241 1630722 D functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria; inner membrane protein translocase component YidC 1629241..1630722 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849881 YP_001054114.1 CDS napC NC_009053.1 1631007 1631621 R cytochrome c-type protein NapC complement(1631007..1631621) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848707 YP_001054115.1 CDS napB NC_009053.1 1631633 1632055 R nitrate reductase cytochrome c-type subunit complement(1631633..1632055) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848740 YP_001054116.1 CDS napH NC_009053.1 1632074 1632967 R part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA; quinol dehydrogenase membrane component complement(1632074..1632967) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849477 YP_001054117.1 CDS napG NC_009053.1 1632967 1633872 R part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA; secreted by twin arginine translocation pathway; quinol dehydrogenase periplasmic component complement(1632967..1633872) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850453 YP_001054118.1 CDS napA NC_009053.1 1634007 1636490 R periplasmic; catalytic subunit; with NapBC catalyzes the reduction of nitrate to nitrite; NapAB receives electrons from NapC; nitrate reductase catalytic subunit complement(1634007..1636490) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850345 YP_001054119.1 CDS napD NC_009053.1 1636522 1636791 R napD protein complement(1636522..1636791) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848830 YP_001054120.1 CDS napF NC_009053.1 1636794 1637324 R ferredoxin-type protein NapF complement(1636794..1637324) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848831 YP_001054121.1 CDS APL_1432 NC_009053.1 1637523 1638098 D NAD(P)H oxidoreductase 1637523..1638098 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849188 YP_001054122.1 CDS APL_1433 NC_009053.1 1638234 1639016 R transposase complement(1638234..1639016) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850105 YP_001054123.1 CDS APL_1434 NC_009053.1 1639058 1639567 R hypothetical protein complement(1639058..1639567) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849233 YP_001054124.1 CDS APL_1435 NC_009053.1 1639673 1640185 R hypothetical protein complement(1639673..1640185) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848901 YP_001054125.1 CDS rne NC_009053.1 1640346 1643333 R ribonuclease E complement(1640346..1643333) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848780 YP_001054126.1 CDS APL_1437 NC_009053.1 1643803 1644810 D hypothetical protein 1643803..1644810 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849229 YP_001054127.1 CDS APL_1438 NC_009053.1 1644880 1645401 R hypothetical protein complement(1644880..1645401) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850542 YP_001054128.1 CDS ubiD NC_009053.1 1645551 1647014 R 3-octaprenyl-4-hydroxybenzoate carboxy-lyase complement(1645551..1647014) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850543 YP_001054129.1 CDS znuA NC_009053.1 1647160 1648137 D involved in transport of zinc(II) with ZnuA and C; high-affinity zinc transporter periplasmic protein 1647160..1648137 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850149 YP_001054130.1 CDS APL_1441 NC_009053.1 1648236 1648847 R hypothetical protein complement(1648236..1648847) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849338 YP_001054131.1 CDS apxID NC_009053.1 1649278 1650714 R RTX-I toxin secretion component complement(1649278..1650714) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849611 YP_001054132.1 CDS apxIB NC_009053.1 1650723 1652846 R pubmed:8181764; toxin RTX-I translocation ATP-binding protein complement(1650723..1652846) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850021 YP_001054133.1 CDS apxIA NC_009053.1 1652927 1655995 R pubmed:8359891; RTX-I toxin determinant A complement(1652927..1655995) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850247 YP_001054134.1 CDS apxIC NC_009053.1 1656005 1656523 R pubmed:8359891; RTX-I toxin-activating lysine-acyltransferase ApxIC complement(1656005..1656523) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849898 YP_001054135.1 CDS afuA NC_009053.1 1656814 1657854 D Fe3+ ABC transporter periplasmic protein 1656814..1657854 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850146 YP_001054136.1 CDS afuB NC_009053.1 1657959 1660022 D ferric transport system permease fbpB 1657959..1660022 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850147 YP_001054137.1 CDS fbpC NC_009053.1 1660069 1661115 D Part of the ABC transporter complex FbpABC involved in Fe(3+) ions import; ferric transporter ATP-binding subunit 1660069..1661115 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850154 YP_001054138.1 CDS mpl NC_009053.1 1661206 1662570 R UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase complement(1661206..1662570) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849899 YP_001054139.1 CDS fbp NC_009053.1 1662693 1663697 D catalyzes the formation of D-fructose 6-phosphate from fructose-1,6-bisphosphate; fructose-1,6-bisphosphatase 1662693..1663697 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849228 YP_001054140.1 CDS APL_1451 NC_009053.1 1663853 1664464 R hypothetical protein complement(1663853..1664464) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849230 YP_001054141.1 CDS serA NC_009053.1 1664928 1666157 R catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate; D-3-phosphoglycerate dehydrogenase complement(1664928..1666157) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849901 YP_001054142.1 CDS rpiA NC_009053.1 1666301 1666960 R Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway; ribose-5-phosphate isomerase A complement(1666301..1666960) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850152 YP_001054143.1 CDS glmM NC_009053.1 1667107 1668441 R catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; phosphoglucosamine mutase complement(1667107..1668441) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849540 YP_001054144.1 CDS ilvA NC_009053.1 1668513 1670039 R threonine deaminase; threonine dehydratase; in Escherichia coli, IlvA is part of the isoleucine biosynthetic pathway; threonine dehydratase complement(1668513..1670039) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849541 YP_001054145.1 CDS slyD NC_009053.1 1670166 1670762 R FKBP-type peptidyl-prolyl cis-trans isomerase SlyD complement(1670166..1670762) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849499 YP_001054146.1 CDS aqpZ NC_009053.1 1671115 1671801 R aquaporin Z complement(1671115..1671801) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849383 YP_001054147.1 CDS APL_1458 NC_009053.1 1671947 1672663 R hypothetical protein complement(1671947..1672663) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850293 YP_001054148.1 CDS APL_1459 NC_009053.1 1672705 1673460 R hypothetical protein complement(1672705..1673460) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850249 YP_001054149.1 CDS APL_1460 NC_009053.1 1673509 1674525 D hypothetical protein 1673509..1674525 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849443 YP_001054150.1 CDS menA NC_009053.1 1674525 1675433 D catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate; 1,4-dihydroxy-2-naphthoate octaprenyltransferase 1674525..1675433 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848805 YP_001054151.1 CDS APL_1462 NC_009053.1 1675512 1675853 R essential respiratory protein A; may be involved in the transfer of iron-sulfur clusters; essential for growth using oxygen or alternate electron acceptors; iron-sulfur cluster insertion protein ErpA complement(1675512..1675853) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849052 YP_001054152.1 CDS APL_1463 NC_009053.1 1676054 1676845 D ABC-transporter 1676054..1676845 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849053 YP_001054153.1 CDS wzm NC_009053.1 1676845 1677576 D ABC transporter 1676845..1677576 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849745 YP_001054154.1 CDS APL_1465 NC_009053.1 1677587 1678366 D hypothetical protein 1677587..1678366 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848719 YP_001054155.1 CDS APL_1466 NC_009053.1 1679260 1679664 D hypothetical protein 1679260..1679664 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849191 YP_001054156.1 CDS rfbD NC_009053.1 1679666 1680814 D UDP-galactopyranose mutase 1679666..1680814 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849905 YP_001054157.1 CDS APL_1468 NC_009053.1 1680877 1681446 D hypothetical protein 1680877..1681446 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849363 YP_001054158.1 CDS APL_1469 NC_009053.1 1681443 1682366 D glycosyl transferase family protein 1681443..1682366 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848665 YP_001054159.1 CDS APL_1470 NC_009053.1 1682372 1683145 D hypothetical protein 1682372..1683145 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849146 YP_001054160.1 CDS APL_1471 NC_009053.1 1683164 1684582 D sugar transferase 1683164..1684582 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849147 YP_001054161.1 CDS rfbB1 NC_009053.1 1684665 1685738 D dTDP-glucose 4,6-dehydratase 1684665..1685738 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850143 YP_001054162.1 CDS rpsU NC_009053.1 1685959 1686174 D a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA; 30S ribosomal protein S21 1685959..1686174 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849891 YP_001054163.1 CDS dnaG NC_009053.1 1686354 1688096 D synthesizes RNA primers at the replication forks; DNA primase 1686354..1688096 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849503 YP_001054164.1 CDS rpoD NC_009053.1 1688201 1690060 D sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this is the primary sigma factor of bacteria; RNA polymerase sigma factor RpoD 1688201..1690060 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849057 YP_001054165.1 CDS tyrS NC_009053.1 1690213 1691403 R catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr); tyrosyl-tRNA synthetase complement(1690213..1691403) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849892 YP_001054166.1 CDS APL_1477 NC_009053.1 1691748 1692212 R hypothetical protein complement(1691748..1692212) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848796 YP_001054167.1 CDS vacB NC_009053.1 1692326 1694683 R ribonuclease R complement(1692326..1694683) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850023 YP_001054168.1 CDS APL_1479 NC_009053.1 1694751 1695266 R thioredoxin-like protein complement(1694751..1695266) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850024 YP_001054169.1 CDS APL_1480 NC_009053.1 1695266 1695898 R negatively controls the expression of fabA and fabB, genes involved in the unsaturated fatty acid biosynthesis; DNA-binding transcriptional repressor FabR complement(1695266..1695898) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849546 YP_001054170.1 CDS oxyR NC_009053.1 1695891 1696784 R Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS, dps, fur and grxA; DNA-binding transcriptional regulator OxyR complement(1695891..1696784) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850297 YP_001054171.1 CDS APL_1482 NC_009053.1 1696909 1697643 D hybrid peroxiredoxin HyPrx5 1696909..1697643 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849888 YP_001054172.1 CDS APL_1483 NC_009053.1 1698048 1698659 D hypothetical protein 1698048..1698659 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849902 YP_001054173.1 CDS APL_1484 NC_009053.1 1698893 1699525 R hypothetical protein complement(1698893..1699525) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848806 YP_001054174.1 CDS pdxY NC_009053.1 1699929 1700789 R catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal; pyridoxamine kinase complement(1699929..1700789) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848730 YP_001054175.1 CDS accA NC_009053.1 1701093 1702046 R catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein; acetyl-CoA carboxylase carboxyltransferase subunit alpha complement(1701093..1702046) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849457 YP_001054176.1 CDS sufI NC_009053.1 1702163 1703572 R protein SufI complement(1702163..1703572) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850294 YP_001054177.1 CDS plsC NC_009053.1 1703581 1704315 R 1-acyl-sn-glycerol-3-phosphate acyltransferase complement(1703581..1704315) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849225 YP_001054178.1 CDS tpx NC_009053.1 1704458 1704958 D antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein; thiol peroxidase 1704458..1704958 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850369 YP_001054179.1 CDS trmE NC_009053.1 1705081 1706439 D in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE; tRNA modification GTPase TrmE 1705081..1706439 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850018 YP_001054180.1 CDS APL_1491 NC_009053.1 1706547 1707902 R hypothetical protein complement(1706547..1707902) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849648 YP_001054181.1 CDS APL_1492 NC_009053.1 1707915 1708187 R ACT domain-containing protein; hypothetical protein complement(1707915..1708187) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849649 YP_001054182.1 CDS APL_1493 NC_009053.1 1708325 1709014 R hypothetical protein complement(1708325..1709014) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848885 YP_001054183.1 CDS ftpA NC_009053.1 1709330 1709899 D fine tangled pili major subunit 1709330..1709899 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849748 YP_001054184.1 CDS APL_1495 NC_009053.1 1710145 1710447 D transcriptional regulator 1710145..1710447 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849664 YP_001054185.1 CDS APL_1496 NC_009053.1 1710594 1711958 D hypothetical protein 1710594..1711958 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849741 YP_001054186.1 CDS APL_1497 NC_009053.1 1712026 1714200 R hypothetical protein complement(1712026..1714200) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849544 YP_001054187.1 CDS mgsA NC_009053.1 1714282 1714740 R catalyzes the formation of methylglyoxal from glycerone phosphate; methylglyoxal synthase complement(1714282..1714740) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849849 YP_001054188.1 CDS thrC NC_009053.1 1714873 1716153 D catalyzes the formation of L-threonine from O-phospho-L-homoserine; threonine synthase 1714873..1716153 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848887 YP_001054189.1 CDS APL_1500 NC_009053.1 1716239 1716748 D hypothetical protein 1716239..1716748 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848888 YP_001054190.1 CDS APL_1501 NC_009053.1 1716790 1717572 D transposase 1716790..1717572 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848778 YP_001054191.1 CDS valS NC_009053.1 1717631 1720495 R valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain; valyl-tRNA synthetase complement(1717631..1720495) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849983 YP_001054192.1 CDS APL_1503 NC_009053.1 1721238 1721414 R hypothetical protein complement(1721238..1721414) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849224 YP_001054193.1 CDS APL_1504 NC_009053.1 1721574 1721996 R acetyltransferase complement(1721574..1721996) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850374 YP_001054194.1 CDS holC NC_009053.1 1721997 1722434 R binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB; DNA polymerase III subunit chi complement(1721997..1722434) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849759 YP_001054195.1 CDS APL_1506 NC_009053.1 1722708 1723151 D LysM domain/BON superfamily protein 1722708..1723151 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850148 YP_001054196.1 CDS tig NC_009053.1 1723353 1724654 D Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer; trigger factor 1723353..1724654 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849723 YP_001054197.1 CDS APL_1508 NC_009053.1 1724787 1725236 D rhodanese-related sulfurtransferase 1724787..1725236 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849724 YP_001054198.1 CDS secB NC_009053.1 1725261 1725761 D molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA; preprotein translocase subunit SecB 1725261..1725761 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849426 YP_001054199.1 CDS gpsA NC_009053.1 1725946 1726956 D catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase 1725946..1726956 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850014 YP_001054200.1 CDS cysE NC_009053.1 1726968 1727783 D catalyzes the O-acetylation of serine; serine acetyltransferase 1726968..1727783 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849361 YP_001054201.1 CDS tufB NC_009053.1 1727979 1729163 R EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu complement(1727979..1729163) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849708 YP_001054202.1 CDS coaA NC_009053.1 1729917 1730867 D catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis; pantothenate kinase 1729917..1730867 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850403 YP_001054203.1 CDS dsbE NC_009053.1 1731002 1731544 D thiol:disulfide interchange protein DsbE 1731002..1731544 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848702 YP_001054204.1 CDS APL_1515 NC_009053.1 1731549 1732016 D hypothetical protein 1731549..1732016 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850075 YP_001054205.1 CDS APL_1516 NC_009053.1 1732016 1732930 D cytochrome c biogenesis factor-like protein 1732016..1732930 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849197 YP_001054206.1 CDS mogA NC_009053.1 1733002 1733586 D forms a trimer; related to eukaryotic protein gephyrin; functions during molybdenum cofactor biosynthesis; molybdenum cofactor biosynthesis protein MogA 1733002..1733586 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850254 YP_001054207.1 CDS glnB NC_009053.1 1733706 1734044 D nitrogen regulatory protein P-II 1733706..1734044 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849241 YP_001054208.1 CDS lspA NC_009053.1 1734123 1734605 D lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis; lipoprotein signal peptidase 1734123..1734605 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849343 YP_001054209.1 CDS ispH NC_009053.1 1734606 1735550 D catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway; 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 1734606..1735550 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849344 YP_001054210.1 CDS APL_1521 NC_009053.1 1735550 1735798 D hypothetical protein 1735550..1735798 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849986 YP_001054211.1 CDS APL_1522 NC_009053.1 1735867 1736466 R hypothetical protein complement(1735867..1736466) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850051 YP_001054212.1 CDS chuW NC_009053.1 1736466 1738283 R coproporphyrinogen III oxidase complement(1736466..1738283) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848479 YP_001054213.1 CDS gst NC_009053.1 1738440 1739057 R glutathione S-transferase complement(1738440..1739057) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848541 YP_001054214.1 CDS lysA NC_009053.1 1739123 1740373 R diaminopimelate decarboxylase complement(1739123..1740373) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849221 YP_001054215.1 CDS frdD NC_009053.1 1740789 1741133 R in conjunction with FrdC acts to anchor the catalytic components of the fumarate reductase to the cytoplasmic membrane; fumarate reductase subunit D complement(1740789..1741133) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850090 YP_001054216.1 CDS frdC NC_009053.1 1741146 1741538 R part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase subunit C complement(1741146..1741538) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850135 YP_001054217.1 CDS frdB NC_009053.1 1741547 1742281 R part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase iron-sulfur subunit complement(1741547..1742281) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850136 YP_001054218.1 CDS frdA NC_009053.1 1742294 1744093 R part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase flavoprotein subunit complement(1742294..1744093) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850125 YP_001054219.1 CDS poxA NC_009053.1 1744436 1745419 D lysine--tRNA ligase beta chain; poxA; class II aminoacyl tRNA synthetase; catalyzes a two-step reaction; first charging a lysine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; lysyl-tRNA synthetase 1744436..1745419 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849092 YP_001054220.1 CDS dapF NC_009053.1 1745501 1746325 R involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate; diaminopimelate epimerase complement(1745501..1746325) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848681 YP_001054221.1 CDS dcuB NC_009053.1 1746506 1747828 D functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to dcuB; anaerobic C4-dicarboxylate transporter 1746506..1747828 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849397 YP_001054222.1 CDS crcB NC_009053.1 1747900 1748271 R camphor resistance-like protein CrcB complement(1747900..1748271) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850326 YP_001054223.1 CDS APL_1534 NC_009053.1 1748274 1749338 R transport system permease complement(1748274..1749338) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848839 YP_001054224.1 CDS anmK NC_009053.1 1749433 1750542 D catalyzes hydrolysis of 1,6-anhydro bond of anyhydro-N-acetylmuramic acid (anhMurNAc) and phosphorylates anhMurNAc to produce N-acetyl-muramate-6-phosphate; involved in murein recycling; anhydro-N-acetylmuramic acid kinase 1749433..1750542 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849027 YP_001054225.1 CDS murQ NC_009053.1 1750596 1751510 D catalyzes the cleavage of the lactyl ether moiety of N-acetylmuramic acid-6-phosphate (MurNAc-6-P) to form N-acetylglucosamine-6-phosphate (GlcNAc-6-P) and lactate; involved in MurNAc dissimilation pathway; N-acetylmuramic acid 6-phosphate etherase 1750596..1751510 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849028 YP_001054226.1 CDS prmA NC_009053.1 1751577 1752458 R methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype; 50S ribosomal protein L11 methyltransferase complement(1751577..1752458) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849675 YP_001054227.1 CDS APL_1538 NC_009053.1 1752542 1753009 R acetyltransferase complement(1752542..1753009) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849809 YP_001054228.1 CDS APL_1539 NC_009053.1 1753013 1753273 R hypothetical protein complement(1753013..1753273) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849524 YP_001054229.1 CDS tldD NC_009053.1 1753394 1754854 R TldD-like protein complement(1753394..1754854) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849276 YP_001054230.1 CDS tilS NC_009053.1 1754984 1756243 D tRNA(Ile)-lysidine synthase 1754984..1756243 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849337 YP_001054231.1 CDS xerD NC_009053.1 1756562 1757455 R site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; XerD specifically exchanges the bottom strands; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerD complement(1756562..1757455) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849196 YP_001054232.1 CDS wecG NC_009053.1 1764006 1764731 R UDP-N-acetyl-D-mannosaminuronic acid transferase complement(1764006..1764731) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849596 YP_001054233.1 CDS APL_1544 NC_009053.1 1764715 1766049 R enterobacterial common antigen polymerase; common antigen polymerase complement(1764715..1766049) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850076 YP_001054234.1 CDS wecF NC_009053.1 1766049 1767119 R catalyzes the synthesis of a lipid-linked intermediate involved in ECA synthesis; 4-alpha-L-fucosyltransferase complement(1766049..1767119) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849404 YP_001054235.1 CDS hcp NC_009053.1 1767397 1769052 D catalyzes the reduction of hydroxylamine to ammonia and water; hydroxylamine reductase 1767397..1769052 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849405 YP_001054236.1 CDS hcr NC_009053.1 1769175 1770194 D HCP oxidoreductase 1769175..1770194 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848843 YP_001054237.1 CDS APL_1548 NC_009053.1 1770236 1771486 R hypothetical protein complement(1770236..1771486) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850319 YP_001054238.1 CDS wecE NC_009053.1 1771474 1772619 R catalyzes the formation of dTDP-D-fucosamine from dTDP-4-oxo-6-deoxy-D-glucose in enterobacterial common antigen biosynthesis; TDP-4-oxo-6-deoxy-D-glucose transaminase complement(1771474..1772619) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848746 YP_001054239.1 CDS wecD NC_009053.1 1772626 1773249 R TDP-fucosamine acetyltransferase complement(1772626..1773249) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849599 YP_001054240.1 CDS wecC NC_009053.1 1773249 1774520 R catalyzes the oxidation of UDP-N-acetyl-D-mannosamine to UDP-N-acetylmannosaminuronic acid; UDP-N-acetyl-D-mannosamine dehydrogenase complement(1773249..1774520) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849827 YP_001054241.1 CDS wecB NC_009053.1 1774599 1775678 R UDP-N-acetylglucosamine 2-epimerase complement(1774599..1775678) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850351 YP_001054242.1 CDS APL_1553 NC_009053.1 1775719 1776597 R hypothetical protein complement(1775719..1776597) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849307 YP_001054243.1 CDS wecA NC_009053.1 1776632 1777705 R undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase complement(1776632..1777705) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849308 YP_001054244.1 CDS hemL NC_009053.1 1778004 1779284 D Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway; glutamate-1-semialdehyde aminotransferase 1778004..1779284 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850218 YP_001054245.1 CDS APL_1556 NC_009053.1 1779339 1780406 R transport system permease complement(1779339..1780406) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848962 YP_001054246.1 CDS mviN NC_009053.1 1780426 1781955 R virulence factor-like MviN complement(1780426..1781955) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850212 YP_001054247.1 CDS rpsT NC_009053.1 1782389 1782652 D binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase; 30S ribosomal protein S20 1782389..1782652 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850402 YP_001054248.1 CDS trkA NC_009053.1 1782709 1784085 R involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain; potassium transporter peripheral membrane protein complement(1782709..1784085) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850067 YP_001054249.1 CDS rsmB NC_009053.1 1784135 1785433 R ribosomal RNA small subunit methyltransferase B complement(1784135..1785433) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849977 YP_001054250.1 CDS selB NC_009053.1 1785447 1787282 R selenocysteine-specific elongation factor complement(1785447..1787282) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849301 YP_001054251.1 CDS selA NC_009053.1 1787279 1788664 R catalyzes the formation of selenocysteinyl-tRNA(Sec) from seryl-tRNA(Sec) and L-selenophosphate in selenoprotein biosynthesis; selenocysteine synthase complement(1787279..1788664) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849302 YP_001054252.1 CDS mioC NC_009053.1 1788841 1789284 D An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin 1788841..1789284 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849677 YP_001054253.1 CDS lyx NC_009053.1 1790122 1791579 R L-xylulose kinase complement(1790122..1791579) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849143 YP_001054254.1 CDS APL_1565 NC_009053.1 1791594 1792037 R gluconolactonase complement(1791594..1792037) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849680 YP_001054255.1 CDS APL_1566 NC_009053.1 1792412 1792594 R hypothetical protein complement(1792412..1792594) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849277 YP_001054256.1 CDS tbpA NC_009053.1 1793088 1795895 R transferrin-binding protein 1 Tbp1 complement(1793088..1795895) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849278 YP_001054257.1 CDS tbpB NC_009053.1 1795909 1797552 R transferrin-binding protein complement(1795909..1797552) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850335 YP_001054258.1 CDS exbD NC_009053.1 1797580 1797990 R biopolymer transport ExbD protein complement(1797580..1797990) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848773 YP_001054259.1 CDS exbB NC_009053.1 1797990 1798658 R biopolymer transport ExbB protein complement(1797990..1798658) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849793 YP_001054260.1 CDS tonB1 NC_009053.1 1798680 1799420 R pubmed:14742511; hypothetical protein complement(1798680..1799420) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849115 YP_001054261.1 CDS APL_1572 NC_009053.1 1799696 1799944 R hypothetical protein complement(1799696..1799944) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849929 YP_001054262.1 CDS APL_1573 NC_009053.1 1800111 1800818 R 2,3-diketo-L-gulonate reductase complement(1800111..1800818) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850062 YP_001054263.1 CDS APL_1574 NC_009053.1 1801340 1801882 D hypothetical protein 1801340..1801882 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850522 YP_001054264.1 CDS APL_1575 NC_009053.1 1801954 1802508 R hypothetical protein complement(1801954..1802508) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850523 YP_001054265.1 CDS kpsF NC_009053.1 1802526 1803461 R arabinose-5-phosphate isomerase complement(1802526..1803461) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848974 YP_001054266.1 CDS kdsB NC_009053.1 1803473 1804231 R CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS; 3-deoxy-manno-octulosonate cytidylyltransferase complement(1803473..1804231) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850210 YP_001054267.1 CDS kdsA NC_009053.1 1804277 1805137 R catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis; 2-dehydro-3-deoxyphosphooctonate aldolase complement(1804277..1805137) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848960 YP_001054268.1 CDS cps5C NC_009053.1 1805186 1806334 R pubmed:9632602; region 2 capsular polysaccharide biosynthesis protein complement(1805186..1806334) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849478 YP_001054269.1 CDS cps5B NC_009053.1 1806349 1807929 R pubmed:9632602; region 2 capsular polysaccharide biosynthesis protein complement(1806349..1807929) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849020 YP_001054270.1 CDS APL_1581 NC_009053.1 1807932 1808897 R pubmed:9632602; glycosyltransferase complement(1807932..1808897) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849402 YP_001054271.1 CDS cpxD NC_009053.1 1809226 1810410 D pubmed:9169799; capsule polysaccharide export protein 1809226..1810410 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849025 YP_001054272.1 CDS cpxC NC_009053.1 1810436 1811593 D pubmed:9169799; capsule polysaccharide export inner-membrane protein 1810436..1811593 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849026 YP_001054273.1 CDS cpxB NC_009053.1 1811593 1812390 D pubmed:9169799; capsule polysaccharide export inner-membrane protein 1811593..1812390 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850217 YP_001054274.1 CDS cpxA NC_009053.1 1812387 1813037 D pubmed:9169799; ATP-binding protein 1812387..1813037 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848980 YP_001054275.1 CDS modF NC_009053.1 1813385 1814857 R contains 2 ATP-binding cassettes; involved in the transport of molybdenum; molybdenum transport ATP-binding protein ModF complement(1813385..1814857) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848837 YP_001054276.1 CDS fmt NC_009053.1 1814950 1815900 R modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth; methionyl-tRNA formyltransferase complement(1814950..1815900) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850457 YP_001054277.1 CDS APL_1588 NC_009053.1 1816063 1817013 R TRAP transporter solute receptor complement(1816063..1817013) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848788 YP_001054278.1 CDS APL_1589 NC_009053.1 1817075 1817803 D hypothetical protein 1817075..1817803 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849120 YP_001054279.1 CDS trkH NC_009053.1 1817884 1819362 D Trk system potassium uptake protein TrkH 1817884..1819362 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849006 YP_001054280.1 CDS APL_1591 NC_009053.1 1819377 1819904 D hypothetical protein 1819377..1819904 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849007 YP_001054281.1 CDS mscL NC_009053.1 1820008 1820397 D forms homopentamer; channel that opens in response to pressure or hypoosmotic shock; large-conductance mechanosensitive channel 1820008..1820397 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849008 YP_001054282.1 CDS lipA NC_009053.1 1820527 1821519 R catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group; lipoyl synthase complement(1820527..1821519) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849701 YP_001054283.1 CDS lipB NC_009053.1 1821631 1822287 R lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein; lipoate-protein ligase B complement(1821631..1822287) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849594 YP_001054284.1 CDS APL_1595 NC_009053.1 1822319 1822618 R hypothetical protein complement(1822319..1822618) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849800 YP_001054285.1 CDS dacA NC_009053.1 1822752 1823930 R D-alanyl-D-alanine carboxypeptidase complement(1822752..1823930) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849686 YP_001054286.1 CDS APL_1597 NC_009053.1 1824026 1824589 R rare lipoprotein A RlpA-like protein complement(1824026..1824589) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850214 YP_001054287.1 CDS mrdB NC_009053.1 1824764 1825888 R rod shape-determining protein complement(1824764..1825888) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849312 YP_001054288.1 CDS mrdA NC_009053.1 1825881 1827842 R penicillin-binding protein 2 complement(1825881..1827842) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849313 YP_001054289.1 CDS APL_1600 NC_009053.1 1827924 1828391 R SPOUT methyltransferase family protein; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA; rRNA large subunit methyltransferase complement(1827924..1828391) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849303 YP_001054290.1 CDS APL_1601 NC_009053.1 1828414 1828728 R hypothetical protein complement(1828414..1828728) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850082 YP_001054291.1 CDS mutS NC_009053.1 1828954 1831548 R This protein performs the mismatch recognition step during the DNA repair process; DNA mismatch repair protein MutS complement(1828954..1831548) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849408 YP_001054292.1 CDS APL_1603 NC_009053.1 1831714 1832463 R amino acid ABC transporter ATP-binding protein complement(1831714..1832463) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849251 YP_001054293.1 CDS APL_1604 NC_009053.1 1832485 1833168 R amino acid ABC transporter permease complement(1832485..1833168) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849463 YP_001054294.1 CDS APL_1605 NC_009053.1 1833350 1834648 R hypothetical protein complement(1833350..1834648) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849629 YP_001054295.1 CDS APL_1606 NC_009053.1 1834920 1835414 D regulator of cell morphogenesis and NO signaling 1834920..1835414 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850454 YP_001054296.1 CDS APL_1607 NC_009053.1 1835493 1835822 R drug resistance protein complement(1835493..1835822) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850455 YP_001054297.1 CDS APL_1608 NC_009053.1 1835910 1836200 R hypothetical protein complement(1835910..1836200) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850461 YP_001054298.1 CDS APL_1609 NC_009053.1 1836354 1836914 R hypothetical protein complement(1836354..1836914) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850563 YP_001054299.1 CDS APL_1610 NC_009053.1 1837087 1837380 R hypothetical protein complement(1837087..1837380) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848770 YP_001054300.1 CDS ureD NC_009053.1 1837396 1838208 R urease accessory protein UreD complement(1837396..1838208) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849315 YP_001054301.1 CDS ureG NC_009053.1 1838377 1839012 R urease accessory protein UreG complement(1838377..1839012) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849436 YP_001054302.1 CDS ureF NC_009053.1 1839033 1839716 R urease accessory protein UreF complement(1839033..1839716) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848971 YP_001054303.1 CDS ureE NC_009053.1 1839728 1840306 R involved in the assembly of the urease metallocenter; possible nickel donor; urease accessory protein UreE complement(1839728..1840306) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849828 YP_001054304.1 CDS gst NC_009053.1 1840422 1841039 R glutathione S-transferase complement(1840422..1841039) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849829 YP_001054305.1 CDS ureC NC_009053.1 1841163 1842881 R ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alpha) and 3 ureAB (gamma/beta) subunits; urease subunit alpha complement(1841163..1842881) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850391 YP_001054306.1 CDS ureB NC_009053.1 1842892 1843197 R ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori and Yersinia enterocolitica the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 UreC (alpha) and 3 UreAB (gamma/beta); in Brucella suis the urease encoded by this operon (one of two urease-encoding operons found in its genome) is involved with urease activity, optimum growth, resistance to low-pH killing in-vitro and persistence in-vivo, while the other operon does not seem to be active; urease subunit beta complement(1842892..1843197) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848933 YP_001054307.1 CDS ureA NC_009053.1 1843387 1843689 R UreA, with UreB and UreC catalyzes the hydrolysis of urea into ammonia and carbon dioxide; nickel metalloenzyme; accessory proteins UreD, UreE, UreF, and UreG are necessary for assembly of the metallocenter; urease subunit gamma complement(1843387..1843689) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850336 YP_001054308.1 CDS utp NC_009053.1 1843761 1844576 R urea transport protein ApUT complement(1843761..1844576) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850193 YP_001054309.1 CDS cbiO NC_009053.1 1844688 1845317 R ABC transporter ATP-binding protein complement(1844688..1845317) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850447 YP_001054310.1 CDS cbiQ NC_009053.1 1845340 1845957 R ABC transport permease protein CbiQ complement(1845340..1845957) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849178 YP_001054311.1 CDS cbiM NC_009053.1 1845964 1846572 R catalyzes the ATP-dependent transport of cobalt; cobalt transport protein CbiM complement(1845964..1846572) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849796 YP_001054312.1 CDS cbiL NC_009053.1 1846573 1847055 R cytoplasmic membrane protein CbiL complement(1846573..1847055) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849797 YP_001054313.1 CDS cbiK NC_009053.1 1847055 1847741 R periplasmic binding protein CbiK complement(1847055..1847741) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849601 YP_001054314.1 CDS apuR NC_009053.1 1848084 1848839 D LysR-type transcriptional regulator 1848084..1848839 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849096 YP_001054315.1 CDS APL_1626 NC_009053.1 1848918 1849379 R hypothetical protein complement(1848918..1849379) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849074 YP_001054316.1 CDS APL_1627 NC_009053.1 1849607 1851472 R hypothetical protein complement(1849607..1851472) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849153 YP_001054317.1 CDS mtlR NC_009053.1 1851533 1852057 R Acts as a repressor of the mtlAD operon; mannitol repressor protein complement(1851533..1852057) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850043 YP_001054318.1 CDS mtlD NC_009053.1 1852057 1853196 R mannitol-1-phosphate 5-dehydrogenase complement(1852057..1853196) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849415 YP_001054319.1 CDS mtlA NC_009053.1 1853283 1855172 R Includes: Mannitol permease IIC component; Mannitol-specific phosphotransferase enzyme IIB component; Mannitol-specific phosphotransferase enzyme IIA component; PTS system mannitol-specific transporter subunit IICBA complement(1853283..1855172) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848748 YP_001054320.1 CDS glmS NC_009053.1 1855480 1857312 R Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source; glucosamine--fructose-6-phosphate aminotransferase complement(1855480..1857312) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848749 YP_001054321.1 CDS APL_1632 NC_009053.1 1857436 1858194 R sugar metabolism transcriptional regulator complement(1857436..1858194) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848867 YP_001054322.1 CDS APL_1633 NC_009053.1 1858332 1858532 R hypothetical protein complement(1858332..1858532) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849923 YP_001054323.1 CDS APL_1634 NC_009053.1 1858631 1859623 R glycosyltransferase complement(1858631..1859623) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849851 YP_001054324.1 CDS APL_1635 NC_009053.1 1859672 1861534 R adhesin processing HmwC-like protein complement(1859672..1861534) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849812 YP_001054325.1 CDS rimO NC_009053.1 1861550 1862881 R catalyzes the methylthiolation of an aspartic acid residue of the S12 protein of the 30S ribosomal subunit; 30S ribosomal protein S12 methylthiotransferase complement(1861550..1862881) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849937 YP_001054326.1 CDS mtn NC_009053.1 1863055 1863753 R MTA/SAH nucleosidase complement(1863055..1863753) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850348 YP_001054327.1 CDS dsbA_2 NC_009053.1 1863753 1864460 R thiol disulfide oxidoreductase complement(1863753..1864460) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849714 YP_001054328.1 CDS slyX NC_009053.1 1864527 1864748 R hypothetical protein complement(1864527..1864748) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849715 YP_001054329.1 CDS fkpA NC_009053.1 1864839 1865570 D FKBP-type peptidyl-prolyl cis-trans isomerase 1864839..1865570 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849158 YP_001054330.1 CDS APL_1641 NC_009053.1 1865682 1866341 D hypothetical protein 1865682..1866341 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849702 YP_001054331.1 CDS tusD NC_009053.1 1866341 1866718 D in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs; sulfur transfer complex subunit TusD 1866341..1866718 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849841 YP_001054332.1 CDS APL_1643 NC_009053.1 1866721 1867092 D hypothetical protein 1866721..1867092 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850350 YP_001054333.1 CDS APL_1644 NC_009053.1 1867105 1867374 D hypothetical protein 1867105..1867374 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850134 YP_001054334.1 CDS atpC NC_009053.1 1873346 1873765 R part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane; F0F1 ATP synthase subunit epsilon complement(1873346..1873765) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848768 YP_001054335.1 CDS atpD NC_009053.1 1873805 1875178 R Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit; F0F1 ATP synthase subunit beta complement(1873805..1875178) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849292 YP_001054336.1 CDS atpG NC_009053.1 1875192 1876058 R Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit; F0F1 ATP synthase subunit gamma complement(1875192..1876058) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850085 YP_001054337.1 CDS atpA NC_009053.1 1876081 1877622 R produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit; F0F1 ATP synthase subunit alpha complement(1876081..1877622) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850203 YP_001054338.1 CDS atpH NC_009053.1 1877635 1878168 R Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex; F0F1 ATP synthase subunit delta complement(1877635..1878168) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850346 YP_001054339.1 CDS atpF NC_009053.1 1878182 1878652 R Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.; F0F1 ATP synthase subunit B complement(1878182..1878652) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850234 YP_001054340.1 CDS atpE NC_009053.1 1878712 1878966 R Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0; F0F1 ATP synthase subunit C complement(1878712..1878966) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848669 YP_001054341.1 CDS atpB NC_009053.1 1879085 1879873 R Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0; F0F1 ATP synthase subunit A complement(1879085..1879873) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849825 YP_001054342.1 CDS APL_1653 NC_009053.1 1879898 1880281 R Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation; F0F1 ATP synthase subunit I complement(1879898..1880281) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849826 YP_001054343.1 CDS gidB NC_009053.1 1880642 1881259 R glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA; 16S rRNA methyltransferase GidB complement(1880642..1881259) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848985 YP_001054344.1 CDS gidA NC_009053.1 1881359 1883251 R GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs; tRNA uridine 5-carboxymethylaminomethyl modification protein GidA complement(1881359..1883251) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850207 YP_001054345.1 CDS APL_1656 NC_009053.1 1883701 1884513 D hypothetical protein 1883701..1884513 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849946 YP_001054346.1 CDS APL_1657 NC_009053.1 1884563 1885345 R amino-acid ABC transporter-binding protein complement(1884563..1885345) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849177 YP_001054347.1 CDS APL_1658 NC_009053.1 1885558 1886034 R hypothetical protein complement(1885558..1886034) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849013 YP_001054348.1 CDS APL_1659 NC_009053.1 1886037 1886414 R hypothetical protein complement(1886037..1886414) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850356 YP_001054349.1 CDS APL_1660 NC_009053.1 1886502 1887329 R mannose permease IID component complement(1886502..1887329) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849822 YP_001054350.1 CDS APL_1661 NC_009053.1 1887340 1888134 R mannose permease IIC component complement(1887340..1888134) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849823 YP_001054351.1 CDS APL_1662 NC_009053.1 1888149 1889117 R Includes: Mannose-specific phosphotransferase enzyme IIA component; Mannose-specific phosphotransferase enzyme IIB component; PTS system mannose-specific transporter subunit IIAB complement(1888149..1889117) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848953 YP_001054352.1 CDS APL_1663 NC_009053.1 1889293 1890105 R transposase-like protein complement(1889293..1890105) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848833 YP_001054353.1 CDS APL_1664 NC_009053.1 1890117 1890626 R transposase complement(1890117..1890626) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850031 YP_001054354.1 CDS gntP_1 NC_009053.1 1890708 1892057 R gluconate permease complement(1890708..1892057) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848952 YP_001054355.1 CDS gntK NC_009053.1 1892235 1892750 D thermosensitive gluconokinase 1892235..1892750 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848711 YP_001054356.1 CDS gntR NC_009053.1 1892822 1893820 R HTH-type transcriptional regulator complement(1892822..1893820) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848900 YP_001054357.1 CDS rbsR NC_009053.1 1893943 1894932 D ribose operon repressor 1893943..1894932 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850343 YP_001054358.1 CDS rbsD NC_009053.1 1895053 1895472 D cytoplasmic mutarotase that catalyzes the conversion between beta-pyran and beta-furan forms of D-ribose; RbsD is required for efficient ribose utilization in E. coli; rbsD-mutant E. coli strains are unable to use ribose as a sole carbon source; D-ribose pyranase 1895053..1895472 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850344 YP_001054359.1 CDS rbsA NC_009053.1 1895485 1896966 D with RbsBCD acts to import ribose into the cell; RbsA contains 2 ATP-binding domain; D-ribose transporter ATP-binding protein 1895485..1896966 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848659 YP_001054360.1 CDS rbsC NC_009053.1 1897019 1897978 D functions to transport ribose at high affinity; forms a complex with RbsA2C2B; ribose ABC transporter permease 1897019..1897978 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849671 YP_001054361.1 CDS rbsB NC_009053.1 1898002 1898874 D periplasmic substrate-binding component of the ATP-dependent ribose transport system; D-ribose transporter subunit RbsB 1898002..1898874 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850077 YP_001054362.1 CDS rbsK NC_009053.1 1898947 1899858 D catalyzes the formation of D-ribose 5-phosphate from ribose; ribokinase 1898947..1899858 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848967 YP_001054363.1 CDS dmsA NC_009053.1 1900092 1902509 D anaerobic dimethyl sulfoxide reductase subunit A 1900092..1902509 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849184 YP_001054364.1 CDS dmsB NC_009053.1 1902519 1903136 D anaerobic dimethyl sulfoxide reductase subunit B 1902519..1903136 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849409 YP_001054365.1 CDS dmsC NC_009053.1 1903138 1903971 D anaerobic dimethyl sulfoxide reductase subunit C 1903138..1903971 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849011 YP_001054366.1 CDS APL_1677 NC_009053.1 1904027 1904632 D binds to the twin-arginine signal peptides of certain proteins, including dimethylsulfoxide reductase and trimethylamine N-oxide reductase that are translocated to the cytoplasmic membrane; twin-argninine leader-binding protein DmsD 1904027..1904632 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849012 YP_001054367.1 CDS APL_1678 NC_009053.1 1904636 1905145 D ferredoxin 1904636..1905145 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849805 YP_001054368.1 CDS APL_1679 NC_009053.1 1905189 1905518 R transcriptional regulator complement(1905189..1905518) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848850 YP_001054369.1 CDS APL_1680 NC_009053.1 1905515 1906846 R hypothetical protein complement(1905515..1906846) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849080 YP_001054370.1 CDS APL_1681 NC_009053.1 1907178 1908869 R hypothetical protein complement(1907178..1908869) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850054 YP_001054371.1 CDS purL NC_009053.1 1908937 1912833 R catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis; phosphoribosylformylglycinamidine synthase complement(1908937..1912833) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848986 YP_001054372.1 CDS fucR NC_009053.1 1913060 1913806 D L-fucose operon activator 1913060..1913806 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848567 YP_001054373.1 CDS fucI NC_009053.1 1914009 1915775 D catalyzes the conversion of the aldose L-fucose into the corresponding ketose L-fuculose; L-fucose isomerase 1914009..1915775 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849689 YP_001054374.1 CDS fucK NC_009053.1 1915853 1917286 D L-fuculokinase 1915853..1917286 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849690 YP_001054375.1 CDS fucU NC_009053.1 1917421 1917855 D fucose operon FucU protein 1917421..1917855 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849287 YP_001054376.1 CDS fucA NC_009053.1 1917906 1918556 D catalyzes the formation of glycerone phosphate and (S)-lactaldehyde from L-fuculose 1-phosphate; L-fuculose phosphate aldolase 1917906..1918556 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850363 YP_001054377.1 CDS fucP NC_009053.1 1918611 1919900 D L-fucose permease 1918611..1919900 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850213 YP_001054378.1 CDS APL_1689 NC_009053.1 1920020 1921171 D L-1,2-propanediol oxidoreductase 1920020..1921171 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848950 YP_001054379.1 CDS APL_1690 NC_009053.1 1921375 1922016 D inner membrane protein 1921375..1922016 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849681 YP_001054380.1 CDS APL_1691 NC_009053.1 1922228 1922887 D ABC transporter, permease protein, amino acid 1922228..1922887 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849108 YP_001054381.1 CDS APL_1692 NC_009053.1 1922877 1923545 D ABC transporter, permease protein, amino acid 1922877..1923545 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850063 YP_001054382.1 CDS APL_1693 NC_009053.1 1923546 1924277 D amino acid ABC transporter ATP-binding protein 1923546..1924277 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850064 YP_001054383.1 CDS APL_1694 NC_009053.1 1924338 1925174 D pubmed:10459579; antigenic protein, ABC transporter-like protein 1924338..1925174 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850202 YP_001054384.1 CDS kpsC NC_009053.1 1925307 1927376 D capsule polysaccharide modification protein LipA 1925307..1927376 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849698 YP_001054385.1 CDS hcsB NC_009053.1 1927399 1928715 D capsule polysaccharide modification protein HcsB 1927399..1928715 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848561 YP_001054386.1 CDS APL_1697 NC_009053.1 1928704 1929798 R hypothetical protein complement(1928704..1929798) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849958 YP_001054387.1 CDS ulaD NC_009053.1 1929811 1930491 R catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate in anaerobic L-ascorbate utilization; 3-keto-L-gulonate-6-phosphate decarboxylase complement(1929811..1930491) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849252 YP_001054388.1 CDS ulaC NC_009053.1 1930564 1931031 R ascorbate-specific phosphotransferase protein IIA component complement(1930564..1931031) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849334 YP_001054389.2 CDS ulaA NC_009053.1 1931109 1932914 R PTS system ascorbate-specific transporter subunits IICB complement(1931109..1932914) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849168 YP_001054390.1 CDS ulaG NC_009053.1 1933388 1934479 D L-ascorbate 6-phosphate lactonase 1933388..1934479 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849169 YP_001054391.1 CDS ulaR NC_009053.1 1934581 1935327 D negative regulator of ulaG and ulaABCDEF; transcriptional repressor UlaR 1934581..1935327 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848517 YP_001054392.1 CDS APL_1703 NC_009053.1 1935413 1936273 D L-xylulose 5-phosphate 3-epimerase activity not yet demonstrated; may be involved in the utilization of 2,3-diketo-L-gulonate; L-xylulose 5-phosphate 3-epimerase 1935413..1936273 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849328 YP_001054393.1 CDS araD NC_009053.1 1936300 1936980 D catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source; L-ribulose-5-phosphate 4-epimerase 1936300..1936980 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850342 YP_001054394.1 CDS APL_1705 NC_009053.1 1937132 1937761 R FKBP-type peptidyl-prolyl cis-trans isomerase complement(1937132..1937761) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850071 YP_001054395.1 CDS APL_1706 NC_009053.1 1938143 1938826 D hypothetical protein 1938143..1938826 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848524 YP_001054396.1 CDS APL_1707 NC_009053.1 1939172 1939606 D hypothetical protein 1939172..1939606 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848903 YP_001054397.1 CDS APL_1708 NC_009053.1 1939752 1940381 D hypothetical protein 1939752..1940381 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848955 YP_001054398.1 CDS APL_1709 NC_009053.1 1940493 1941149 D hypothetical protein 1940493..1941149 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848956 YP_001054399.1 CDS rfaD NC_009053.1 1941209 1942135 R catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose; ADP-L-glycero-D-manno-heptose-6-epimerase complement(1941209..1942135) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849464 YP_001054400.1 CDS def NC_009053.1 1942275 1942739 R cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase complement(1942275..1942739) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849403 YP_001054401.1 CDS smf NC_009053.1 1942973 1944127 D DNA-processing protein subunit A 1942973..1944127 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849130 YP_001054402.1 CDS APL_1713 NC_009053.1 1944171 1946177 R hypothetical protein complement(1944171..1946177) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849000 YP_001054403.1 CDS ulaA NC_009053.1 1946399 1947754 R membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr; PTS system ascorbate-specific transporter subunit IIC complement(1946399..1947754) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848704 YP_001054404.1 CDS sgaB NC_009053.1 1947763 1948035 R PTS system galactitol-specific transporter subunit IIB complement(1947763..1948035) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849932 YP_001054405.1 CDS secE NC_009053.1 1948338 1948751 D forms a complex with SecY and SecG; SecYEG forms a putative protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force; preprotein translocase subunit SecE 1948338..1948751 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850557 YP_001054406.1 CDS nusG NC_009053.1 1948786 1949316 D Modulates Rho-dependent transcription termination; transcription antitermination protein NusG 1948786..1949316 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850558 YP_001054407.1 CDS rplK NC_009053.1 1949605 1950033 D binds directly to 23S ribosomal RNA; 50S ribosomal protein L11 1949605..1950033 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848949 YP_001054408.1 CDS rplA NC_009053.1 1950038 1950727 D in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA; 50S ribosomal protein L1 1950038..1950727 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849494 YP_001054409.1 CDS rplJ NC_009053.1 1951016 1951507 D binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit; 50S ribosomal protein L10 1951016..1951507 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849068 YP_001054410.1 CDS rplL NC_009053.1 1951568 1951936 D present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors; 50S ribosomal protein L7/L12 1951568..1951936 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849283 YP_001054411.1 CDS APL_1722 NC_009053.1 1952100 1952372 D hypothetical protein 1952100..1952372 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849261 YP_001054412.1 CDS APL_1723 NC_009053.1 1952377 1953633 D hypothetical protein 1952377..1953633 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848987 YP_001054413.1 CDS APL_1724 NC_009053.1 1954021 1954560 D hypothetical protein 1954021..1954560 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848895 YP_001054414.1 CDS APL_1725 NC_009053.1 1955367 1956155 D hypothetical protein 1955367..1956155 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848896 YP_001054415.1 CDS APL_1726 NC_009053.1 1956260 1956808 D hypothetical protein 1956260..1956808 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848832 YP_001054416.1 CDS rpoB NC_009053.1 1957228 1961256 D DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme; DNA-directed RNA polymerase subunit beta 1957228..1961256 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848804 YP_001054417.1 CDS rpoC NC_009053.1 1961382 1965620 D DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter; DNA-directed RNA polymerase subunit beta' 1961382..1965620 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850553 YP_001054418.1 CDS APL_1729 NC_009053.1 1965725 1967146 D hypothetical protein 1965725..1967146 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849159 YP_001054419.1 CDS APL_1730 NC_009053.1 1967877 1968107 D hypothetical protein 1967877..1968107 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850444 YP_001054420.1 CDS APL_1731 NC_009053.1 1968119 1968505 D hypothetical protein 1968119..1968505 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849848 YP_001054421.1 CDS APL_1732 NC_009053.1 1968640 1969056 R hypothetical protein complement(1968640..1969056) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848982 YP_001054422.1 CDS APL_1733 NC_009053.1 1969302 1969952 D hypothetical protein 1969302..1969952 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848983 YP_001054423.1 CDS APL_1734 NC_009053.1 1970132 1970911 R hypothetical protein complement(1970132..1970911) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849587 YP_001054424.1 CDS hslU NC_009053.1 1970984 1972306 R heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease ATP-binding subunit HslU complement(1970984..1972306) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849314 YP_001054425.1 CDS hslV NC_009053.1 1972361 1972882 R heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease peptidase subunit complement(1972361..1972882) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849526 YP_001054426.1 CDS sfsA NC_009053.1 1972961 1973674 R Regulatory factor involved in maltose metabolism; sugar fermentation stimulation protein A complement(1972961..1973674) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848991 YP_001054427.1 CDS APL_1738 NC_009053.1 1973932 1974324 R lactoylglutathione lyase complement(1973932..1974324) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849987 YP_001054428.1 CDS mutY NC_009053.1 1974422 1975567 D A/G-specific adenine glycosylase 1974422..1975567 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848691 YP_001054429.1 CDS APL_1740 NC_009053.1 1975571 1975846 D hypothetical protein 1975571..1975846 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848882 YP_001054430.1 CDS mltC NC_009053.1 1975864 1976961 D Murein hydrolase C; membrane-bound; lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; murein transglycosylase C 1975864..1976961 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848883 YP_001054431.1 CDS srp54 NC_009053.1 1977954 1979345 D signal recognition particle protein (sigma-54 like protein) 1977954..1979345 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848475 YP_001054432.1 CDS APL_1743 NC_009053.1 1979499 1981163 R Ser/Thr protein phosphatase family protein complement(1979499..1981163) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848643 YP_001054433.1 CDS ubiF NC_009053.1 1981355 1982521 R 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase complement(1981355..1982521) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848618 YP_001054434.1 CDS APL_1745 NC_009053.1 1982555 1982863 R hypothetical protein complement(1982555..1982863) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848619 YP_001054435.1 CDS APL_1746 NC_009053.1 1982836 1983150 R hypothetical protein complement(1982836..1983150) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849401 YP_001054436.1 CDS comM NC_009053.1 1983337 1984863 D competence protein comM 1983337..1984863 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848710 YP_001054437.1 CDS APL_1748 NC_009053.1 1984988 1986091 D Outer membrane lipoprotein A precursor 1984988..1986091 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849489 YP_001054438.1 CDS APL_1749 NC_009053.1 1986137 1986901 R catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA; acyl-CoA thioester hydrolase YfbB complement(1986137..1986901) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849121 YP_001054439.1 CDS menD NC_009053.1 1986901 1988607 R SEPHCHC synthase; forms 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1- carboxylate from 2-oxoglutarate and isochorismate in menaquinone biosynthesis; 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase complement(1986901..1988607) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849122 YP_001054440.1 CDS APL_1751 NC_009053.1 1988860 1989453 D hypothetical protein 1988860..1989453 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848570 YP_001054441.1 CDS nanE NC_009053.1 1989491 1990180 D Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate; N-acetylmannosamine-6-phosphate 2-epimerase 1989491..1990180 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849607 YP_001054442.1 CDS nanK NC_009053.1 1990190 1991062 D catalyzes the phosphorylation of the N-acetylmannosamine (ManNAc) liberated from N-acetyl-neuraminic acid by the nanA protein; N-acetylmannosamine kinase 1990190..1991062 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849440 YP_001054443.1 CDS nanA NC_009053.1 1991083 1991961 D catalyzes the formation of pyruvate and N-acetylmannosamine from N-acetylneuraminic acid; N-acetylneuraminate lyase 1991083..1991961 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848657 YP_001054444.1 CDS nagB NC_009053.1 1992011 1992814 D catalyzes the reversible formation of fructose 6-phosphate from glucosamine 6-phosphate; glucosamine-6-phosphate deaminase 1992011..1992814 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848658 YP_001054445.1 CDS nagA NC_009053.1 1992866 1994011 D catalyzes the formation of glucosamine 6-phosphate from N-acetylglucosamine 6-phosphate; N-acetylglucosamine-6-phosphate deacetylase 1992866..1994011 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848984 YP_001054446.1 CDS fumC NC_009053.1 1994160 1995554 R class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle; fumarate hydratase complement(1994160..1995554) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849162 YP_001054447.1 CDS APL_1758 NC_009053.1 1995709 1996365 R DNA transformation protein complement(1995709..1996365) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850142 YP_001054448.1 CDS rpsJ NC_009053.1 1996773 1997084 D 30S ribosomal protein S10 1996773..1997084 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849705 YP_001054449.1 CDS rplC NC_009053.1 1997110 1997736 D binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin; 50S ribosomal protein L3 1997110..1997736 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849706 YP_001054450.1 CDS rplD NC_009053.1 1997752 1998354 D L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA; 50S ribosomal protein L4 1997752..1998354 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849201 YP_001054451.1 CDS rplW NC_009053.1 1998351 1998656 D binds third domain of 23S rRNA and protein L29; part of exit tunnel; 50S ribosomal protein L23 1998351..1998656 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849806 YP_001054452.1 CDS rplB NC_009053.1 1998677 1999498 D one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation; 50S ribosomal protein L2 1998677..1999498 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849586 YP_001054453.1 CDS rpsS NC_009053.1 1999526 1999801 D protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA; 30S ribosomal protein S19 1999526..1999801 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849009 YP_001054454.1 CDS rplV NC_009053.1 1999812 2000144 D binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center; 50S ribosomal protein L22 1999812..2000144 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849010 YP_001054455.1 CDS rpsC NC_009053.1 2000163 2000870 D forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation; 30S ribosomal protein S3 2000163..2000870 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848566 YP_001054456.1 CDS rplP NC_009053.1 2000884 2001294 D located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e; 50S ribosomal protein L16 2000884..2001294 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850219 YP_001054457.1 CDS rpmC NC_009053.1 2001294 2001485 D one of the stabilizing components for the large ribosomal subunit; 50S ribosomal protein L29 2001294..2001485 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849389 YP_001054458.1 CDS rpsQ NC_009053.1 2001485 2001739 D primary binding protein; helps mediate assembly; involved in translation fidelity; 30S ribosomal protein S17 2001485..2001739 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849678 YP_004770516.1 CDS APL_1769a NC_009053.1 2001979 2002350 D 50S ribosomal protein L14 2001979..2002350 Actinobacillus pleuropneumoniae serovar 5b str. L20 11031964 YP_001054459.1 CDS rplX NC_009053.1 2002361 2002672 D assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel; 50S ribosomal protein L24 2002361..2002672 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849679 YP_001054460.1 CDS rplE NC_009053.1 2002690 2003229 D part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13; 50S ribosomal protein L5 2002690..2003229 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850224 YP_001054461.1 CDS rpsN NC_009053.1 2003241 2003546 D located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif; 30S ribosomal protein S14 2003241..2003546 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849185 YP_001054462.1 CDS rpsH NC_009053.1 2003583 2003975 D binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; 30S ribosomal protein S8 2003583..2003975 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849183 YP_001054463.1 CDS rplF NC_009053.1 2003992 2004525 D ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance; 50S ribosomal protein L6 2003992..2004525 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850353 YP_001054464.1 CDS rplR NC_009053.1 2004540 2004893 D binds 5S rRNA along with protein L5 and L25; 50S ribosomal protein L18 2004540..2004893 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850354 YP_001054465.1 CDS rpsE NC_009053.1 2004908 2005408 D located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance; 30S ribosomal protein S5 2004908..2005408 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849674 YP_001054466.1 CDS rpmD NC_009053.1 2005415 2005594 D L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7; 50S ribosomal protein L30 2005415..2005594 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849961 YP_001054467.1 CDS rplO NC_009053.1 2005599 2006033 D late assembly protein; 50S ribosomal protein L15 2005599..2006033 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848606 YP_001054468.1 CDS secY NC_009053.1 2006037 2007359 D forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY 2006037..2007359 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848922 YP_001054469.1 CDS rpmJ NC_009053.1 2007385 2007498 D smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif; 50S ribosomal protein L36 2007385..2007498 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848923 YP_001054470.1 CDS rpsM NC_009053.1 2007635 2007991 D located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA; 30S ribosomal protein S13 2007635..2007991 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849271 YP_001054471.1 CDS rpsK NC_009053.1 2008008 2008397 D located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3; 30S ribosomal protein S11 2008008..2008397 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848916 YP_001054472.1 CDS rpsD NC_009053.1 2008426 2009052 D primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination; 30S ribosomal protein S4 2008426..2009052 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848996 YP_001054473.1 CDS rpoA NC_009053.1 2009118 2010107 D catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha 2009118..2010107 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849580 YP_001054474.1 CDS rplQ NC_009053.1 2010213 2010527 D 50S ribosomal protein L17 2010213..2010527 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849581 YP_001054475.1 CDS rpsP NC_009053.1 2010764 2011012 D binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity; 30S ribosomal protein S16 2010764..2011012 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848767 YP_001054476.1 CDS rimM NC_009053.1 2011046 2011573 D Essential for efficient processing of 16S rRNA; 16S rRNA-processing protein RimM 2011046..2011573 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849140 YP_001054477.1 CDS trmD NC_009053.1 2011631 2012386 D methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA; tRNA (guanine-N(1)-)-methyltransferase 2011631..2012386 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848951 YP_001054478.1 CDS rplS NC_009053.1 2012412 2012762 D this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site; 50S ribosomal protein L19 2012412..2012762 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849390 YP_001054479.1 CDS APL_1790 NC_009053.1 2012932 2014125 R hypothetical protein complement(2012932..2014125) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849391 YP_001054480.1 CDS APL_1791 NC_009053.1 2014341 2015456 D periplasmic iron/siderophore binding protein 2014341..2015456 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849022 YP_001054481.1 CDS APL_1792 NC_009053.1 2015459 2016340 D Fe(III) dicitrate ABC transporter permease 2015459..2016340 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850471 YP_001054482.1 CDS APL_1793 NC_009053.1 2016356 2017123 D Fe(III) dicitrate ABC transporter, ATP-binding protein 2016356..2017123 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849244 YP_001054483.1 CDS APL_1794 NC_009053.1 2017133 2017564 D pseudoazurin 2017133..2017564 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849373 YP_001054484.1 CDS APL_1795 NC_009053.1 2017573 2018679 D periplasmic iron/siderophore binding protein 2017573..2018679 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849374 YP_001054485.1 CDS APL_1796 NC_009053.1 2018735 2019586 D hypothetical protein 2018735..2019586 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849085 YP_001054486.1 CDS torD NC_009053.1 2019629 2020228 R TorD; involved in the biogenesis of torA; acts on torA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor; chaperone protein TorD complement(2019629..2020228) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850316 YP_001054487.1 CDS torA NC_009053.1 2020228 2022711 R trimethylamine-N-oxide reductase precursor complement(2020228..2022711) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848614 YP_001054488.1 CDS torC NC_009053.1 2022721 2023341 R pentahemic c-type cytochrome complement(2022721..2023341) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849763 YP_001054489.1 CDS glyQ NC_009053.1 2023532 2024437 D glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit alpha 2023532..2024437 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849764 YP_001054490.1 CDS APL_1801 NC_009053.1 2024484 2024867 D hypothetical protein 2024484..2024867 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850144 YP_001054491.1 CDS APL_1802 NC_009053.1 2025340 2025744 D hypothetical protein 2025340..2025744 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850392 YP_001054492.1 CDS glyS NC_009053.1 2025782 2027851 D glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit beta 2025782..2027851 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848617 YP_001054493.1 CDS APL_1804 NC_009053.1 2027967 2028257 D hypothetical protein 2027967..2028257 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848622 YP_001054494.1 CDS xerC NC_009053.1 2028258 2029268 D site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerC 2028258..2029268 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848623 YP_001054495.1 CDS APL_1806 NC_009053.1 2029272 2029661 R hypothetical protein complement(2029272..2029661) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849081 YP_001054496.1 CDS APL_1807 NC_009053.1 2029725 2030471 R hypothetical protein complement(2029725..2030471) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850020 YP_001054497.1 CDS lpxH NC_009053.1 2030513 2031244 R catalyzes the formation of 2,3=diacylglucosamine 1-phosphate from UDP-2,3=diacylglucosamine; UDP-2,3-diacylglucosamine hydrolase complement(2030513..2031244) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848921 YP_001054498.1 CDS APL_1809 NC_009053.1 2031277 2031801 R hypothetical protein complement(2031277..2031801) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848612 YP_001054499.1 CDS APL_1810 NC_009053.1 2031836 2032624 R Mg-dependent DNAse complement(2031836..2032624) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848613 YP_001054500.1 CDS APL_1811 NC_009053.1 2033633 2034265 D hypothetical protein 2033633..2034265 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849623 YP_001054501.1 CDS macA NC_009053.1 2036534 2037310 R macrolide-specific efflux protein complement(2036534..2037310) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848873 YP_001054502.1 CDS APL_1815 NC_009053.1 2037606 2038382 R hypothetical protein complement(2037606..2038382) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850564 YP_001054503.1 CDS holB NC_009053.1 2038713 2039696 R catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA; DNA polymerase III subunit delta' complement(2038713..2039696) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848871 YP_001054504.1 CDS tmk NC_009053.1 2039699 2040325 R catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP); thymidylate kinase complement(2039699..2040325) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850003 YP_001054505.1 CDS APL_1818 NC_009053.1 2040329 2041363 R hypothetical protein complement(2040329..2041363) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850004 YP_001054506.1 CDS acpP NC_009053.1 2041962 2042195 R carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein complement(2041962..2042195) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848526 YP_001054507.1 CDS rpe NC_009053.1 2042459 2043133 R ribulose-phosphate 3-epimerase complement(2042459..2043133) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850554 YP_001054508.1 CDS rpmE2 NC_009053.1 2043355 2043624 D RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 2043355..2043624 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848556 YP_001054509.1 CDS rpmJ NC_009053.1 2043638 2043763 D smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group do not have the motif; 50S ribosomal protein L36 2043638..2043763 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848557 YP_001054510.1 CDS pbpB NC_009053.1 2043868 2046270 R penicillin-binding protein 1B (PBP1b) complement(2043868..2046270) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849753 YP_001054511.1 CDS menB NC_009053.1 2046349 2047206 R catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA; naphthoate synthase complement(2046349..2047206) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849102 YP_001054512.1 CDS spoT NC_009053.1 2047341 2049047 R guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase (ppGpp)ase) complement(2047341..2049047) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850525 YP_001054513.1 CDS rpoZ NC_009053.1 2049150 2049425 R promotes RNA polymerase assembly or stability; latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits; DNA-directed RNA polymerase subunit omega complement(2049150..2049425) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850526 YP_001054514.1 CDS recG NC_009053.1 2049552 2051633 R catalyzes branch migration in Holliday junction intermediates; ATP-dependent DNA helicase RecG complement(2049552..2051633) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848872 YP_001054515.1 CDS APL_1828 NC_009053.1 2051757 2052122 R PilT protein-like protein complement(2051757..2052122) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850238 YP_001054516.1 CDS APL_1829 NC_009053.1 2052185 2052472 R hypothetical protein complement(2052185..2052472) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849525 YP_001054517.1 CDS syp NC_009053.1 2052678 2054393 D catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro); prolyl-tRNA synthetase 2052678..2054393 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849609 YP_001054518.1 CDS APL_1831 NC_009053.1 2054650 2055231 R Bacteria have multiple sigma factors which are active under specific conditions; the sigma factor binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; RNA polymerase sigma factor complement(2054650..2055231) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849610 YP_001054519.1 CDS APL_1832 NC_009053.1 2055320 2056276 D in Escherichia coli this periplasmic enzyme was found to encode the periplasmic catalytic subunit of an oxidoreductase; sulfite oxidase activity not demonstrated; requires inner membrane anchor protein YedZ; sulfite oxidase subunit YedY 2055320..2056276 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850019 YP_001054520.1 CDS APL_1833 NC_009053.1 2056276 2056869 D in Escherichia coli this inner membrane protein was found to anchor the periplasmic catalytic oxidoreductase YedY; sulfite oxidase activity not demonstrated; contains heme; sulfite oxidase subunit YedZ 2056276..2056869 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850245 YP_001054521.1 CDS rpoH NC_009053.1 2056980 2057930 R binds with the catalytic core of RNA polymerase to produce the holoenzyme; this sigma factor is responsible for the expression of heat shock promoters; RNA polymerase factor sigma-32 complement(2056980..2057930) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849511 YP_001054522.1 CDS glpT NC_009053.1 2058079 2059236 R glycerol-3-phosphate transporter complement(2058079..2059236) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849789 YP_001054523.1 CDS APL_1836 NC_009053.1 2059991 2060503 D hypothetical protein 2059991..2060503 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849790 YP_001054524.1 CDS asnA NC_009053.1 2061014 2062006 R catalyzes the formation of asparagine from aspartate and ammonia; asparagine synthetase AsnA complement(2061014..2062006) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849781 YP_001054525.1 CDS asnC NC_009053.1 2062188 2062649 D transcriptional repressor of asnA which codes for aspartate-ammonia ligase; DNA-binding transcriptional regulator AsnC 2062188..2062649 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849437 YP_001054526.1 CDS udp NC_009053.1 2062838 2063602 D catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate; involved in the pyrimidine salvage pathway; uridine phosphorylase 2062838..2063602 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848809 YP_001054527.1 CDS ubiC NC_009053.1 2063672 2064148 D 4-hydroxybenzoate synthetase 2063672..2064148 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848810 YP_001054528.1 CDS murI NC_009053.1 2064220 2065017 D converts L-glutamate to D-glutamate, a component of peptidoglycan; glutamate racemase 2064220..2065017 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850271 YP_001054529.1 CDS cysI NC_009053.1 2071381 2073147 R hemoprotein; NADPH dependent; with the alpha subunit (a flavoprotein) catalyzes the reduction of sulfite to sulfide; sulfite reductase subunit beta complement(2071381..2073147) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848697 YP_001054530.1 CDS cysJ NC_009053.1 2073175 2074986 R sulfite reductase [NADPH] flavoprotein alpha-component (SIR-FP) complement(2073175..2074986) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849567 YP_001054531.1 CDS cysN NC_009053.1 2075287 2076018 R sulfate adenylate transferase subunit 1 complement(2075287..2076018) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849912 YP_001054532.1 CDS sbp NC_009053.1 2076271 2077065 D sulfate-binding protein 2076271..2077065 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850426 YP_001054533.1 CDS cysT NC_009053.1 2077084 2077896 D sulfate transport system permease protein cysT 2077084..2077896 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849189 YP_001054534.1 CDS cysW NC_009053.1 2077909 2078721 D sulfate transport system permease protein cysW 2077909..2078721 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849190 YP_001054535.1 CDS cysA NC_009053.1 2078734 2079804 D sulfate/thiosulfate import ATP-binding protein cysA 2078734..2079804 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850485 YP_001054536.1 CDS lldD NC_009053.1 2079893 2081038 R flavin mononucleotide-dependent dehydrogenase; functions in aerobic respiration and also has a role in anaerobic nitrate respiration; L-lactate dehydrogenase complement(2079893..2081038) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849717 YP_001054537.1 CDS birA NC_009053.1 2081220 2081984 R bifunctional biotin operon repressor/biotin synthetase BirA complement(2081220..2081984) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848554 YP_001054538.1 CDS murB NC_009053.1 2081993 2083027 R catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis; UDP-N-acetylenolpyruvoylglucosamine reductase complement(2081993..2083027) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849933 YP_001054539.1 CDS ompA NC_009053.1 2083177 2084271 R Outer membrane protein P5 precursor (OMP P5) complement(2083177..2084271) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849934 YP_001054540.1 CDS ilvC NC_009053.1 2084660 2086141 R catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis; ketol-acid reductoisomerase complement(2084660..2086141) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849756 YP_001054541.1 CDS pqiA NC_009053.1 2086378 2087619 D hypothetical protein 2086378..2087619 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849425 YP_001054542.1 CDS APL_1855 NC_009053.1 2087796 2088896 D hypothetical protein 2087796..2088896 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850504 YP_001054543.1 CDS APL_1856 NC_009053.1 2088868 2089221 D hypothetical protein 2088868..2089221 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850505 YP_001054544.1 CDS merP NC_009053.1 2089218 2089532 D Copper chaperone; MerP 2089218..2089532 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849980 YP_001054545.1 CDS APL_1858 NC_009053.1 2089760 2090005 R hypothetical protein complement(2089760..2090005) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848546 YP_001054546.1 CDS APL_1859 NC_009053.1 2090045 2090944 R NADH-dependent butanol dehydrogenase 1 complement(2090045..2090944) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849263 YP_001054547.1 CDS lysR NC_009053.1 2091060 2091962 D LysR protein 2091060..2091962 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848539 YP_001054548.1 CDS dapD NC_009053.1 2092166 2092990 D catalyzes the formation of N-succinyl-2-amino-6-ketopimelate from succinyl-CoA and tetrahydrodipicolinate in the lysine biosynthetic pathway; 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase 2092166..2092990 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848540 YP_001054549.1 CDS aroQ NC_009053.1 2093055 2093519 D catalyzes the formation of 3-dehydroshikimate from 3-dehydroquinate in chorismate biosynthesis; 3-dehydroquinate dehydratase 2093055..2093519 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849643 YP_001054550.1 CDS APL_1863 NC_009053.1 2093512 2094300 D glycosyltransferase 2093512..2094300 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850008 YP_001054551.1 CDS accB NC_009053.1 2094471 2095010 D biotin carboxyl carrier protein of acetyl-CoA carboxylase (BCCP) 2094471..2095010 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848716 YP_001054552.1 CDS accC NC_009053.1 2095087 2096430 D an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxylase subunit 2095087..2096430 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848717 YP_001054553.1 CDS mobAB NC_009053.1 2096473 2097564 R in Escherichia coli MobA links a guanosine 5'-phosphate to molydopterin to form molybdopterin guanine dinucleotide during molybdenum cofactor biosynthesis; MobB is not essential but has been found to interact with multiple proteins involved in the molybdopterin guanine dinucleotide cofactor biosynthesis pathway; bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobA/MobB complement(2096473..2097564) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848790 YP_001054554.1 CDS APL_1867 NC_009053.1 2097651 2097920 D hypothetical protein 2097651..2097920 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848559 YP_001054555.1 CDS dsbA NC_009053.1 2097964 2098602 D Thiol:disulfide interchange protein dsbA precursor 2097964..2098602 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849992 YP_001054556.1 CDS APL_1869 NC_009053.1 2098821 2099300 R hypothetical protein complement(2098821..2099300) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849787 YP_001054557.1 CDS APL_1870 NC_009053.1 2099777 2100700 R hypothetical protein complement(2099777..2100700) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849788 YP_001054558.1 CDS APL_1871 NC_009053.1 2100812 2101567 R hypothetical protein complement(2100812..2101567) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848792 YP_001054559.1 CDS APL_1872 NC_009053.1 2101585 2102253 R D-alanyl-D-alanine carboxypeptidase complement(2101585..2102253) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849766 YP_001054560.1 CDS dapE NC_009053.1 2102272 2103405 R dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica.; succinyl-diaminopimelate desuccinylase complement(2102272..2103405) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849441 YP_001054561.1 CDS arsC NC_009053.1 2103428 2103778 R ArsC protein complement(2103428..2103778) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849442 YP_001054562.1 CDS APL_1875 NC_009053.1 2103986 2104696 D hypothetical protein 2103986..2104696 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850150 YP_001054563.1 CDS folP NC_009053.1 2104747 2105592 R dihydropteroate synthase complement(2104747..2105592) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850494 YP_001054564.1 CDS rluC NC_009053.1 2105654 2106619 R catalyzes the transformation of uracil to pseudouracil at nucleotides U955, U2504, and U2580 in 23S rRNA; 23S rRNA pseudouridylate synthase C complement(2105654..2106619) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849513 YP_001054565.1 CDS mscS NC_009053.1 2109487 2110398 D small-conductance mechanosensitive channel 2109487..2110398 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849347 YP_001054566.1 CDS APL_1881 NC_009053.1 2110594 2111772 D hypothetical protein 2110594..2111772 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849605 YP_001054567.1 CDS APL_1882 NC_009053.1 2111784 2112536 D hypothetical protein 2111784..2112536 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848947 YP_001054568.1 CDS ptrA NC_009053.1 2112604 2115552 R protease 3 complement(2112604..2115552) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848948 YP_001054569.1 CDS recC NC_009053.1 2115561 2118905 R exodeoxyribonuclease V subunit gamma complement(2115561..2118905) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849210 YP_001054570.1 CDS APL_1885 NC_009053.1 2119010 2119306 R hypothetical protein complement(2119010..2119306) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848827 YP_001054571.1 CDS APL_1886 NC_009053.1 2119296 2119952 R hypothetical protein complement(2119296..2119952) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848828 YP_001054572.1 CDS pulJ NC_009053.1 2119962 2120495 R hypothetical protein complement(2119962..2120495) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849215 YP_001054573.1 CDS pulG NC_009053.1 2120620 2121150 R hypothetical protein complement(2120620..2121150) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849727 YP_001054574.1 CDS fabA NC_009053.1 2121238 2121768 R catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to 2,3-decenoyl-ACP or 3,4-decenoyl-ACP; 3-hydroxydecanoyl-ACP dehydratase complement(2121238..2121768) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849568 YP_001054575.1 CDS lonH NC_009053.1 2121879 2123516 R protease La-like protein complement(2121879..2123516) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849569 YP_001054576.1 CDS APL_1891 NC_009053.1 2123601 2124047 D hypothetical protein 2123601..2124047 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850376 YP_001054577.1 CDS trpS NC_009053.1 2124119 2124982 R tryptophanyl-tRNA synthetase complement(2124119..2124982) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848530 YP_001054578.1 CDS gph NC_009053.1 2125286 2125951 R catalyzes the dephosphorylation of 2-phosphoglycolate to form glycolate and phosphate; phosphoglycolate phosphatase complement(2125286..2125951) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849925 YP_001054579.1 CDS APL_1894 NC_009053.1 2126121 2126351 R hypothetical protein complement(2126121..2126351) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849917 YP_001054580.1 CDS lgt NC_009053.1 2126510 2127304 R transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein; prolipoprotein diacylglyceryl transferase complement(2126510..2127304) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849918 YP_001054581.1 CDS APL_1896 NC_009053.1 2127357 2128148 R hypothetical protein complement(2127357..2128148) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848532 YP_001054582.1 CDS nudH NC_009053.1 2128145 2128765 R hydrolyzes diadenosine polyphosphate; dinucleoside polyphosphate hydrolase complement(2128145..2128765) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848701 YP_001054583.1 CDS ap2029 NC_009053.1 2129311 2130078 R hypothetical protein complement(2129311..2130078) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848784 YP_001054584.1 CDS ppa NC_009053.1 2130174 2130701 R catalyzes the hydrolysis of pyrophosphate to phosphate; inorganic pyrophosphatase complement(2130174..2130701) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848785 YP_001054585.1 CDS APL_1900 NC_009053.1 2130775 2131485 D hypothetical protein 2130775..2131485 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849626 YP_001054586.1 CDS rraA NC_009053.1 2131532 2132029 R regulator of RNase E; increases half-life and abundance of RNAs; interacts with RNase E possibly inhibiting catalytic activity; ribonuclease activity regulator protein RraA complement(2131532..2132029) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850450 YP_001054587.1 CDS yrhG NC_009053.1 2132332 2133024 D transport protein YrhG 2132332..2133024 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850539 YP_001054588.1 CDS APL_1903 NC_009053.1 2133195 2134019 D hypothetical protein 2133195..2134019 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850232 YP_001054589.1 CDS APL_1904 NC_009053.1 2134138 2134926 R hypothetical protein complement(2134138..2134926) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850233 YP_001054590.1 CDS dnaJ NC_009053.1 2135185 2136327 R chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; chaperone protein DnaJ complement(2135185..2136327) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849429 YP_001054591.1 CDS dnaK NC_009053.1 2136557 2138455 R heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria; molecular chaperone DnaK complement(2136557..2138455) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848587 YP_001054592.1 CDS xylB NC_009053.1 2138730 2140175 R xylulose kinase complement(2138730..2140175) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849661 YP_001054593.1 CDS xylA NC_009053.1 2140373 2141692 R catalyzes the interconversion of D-xylose to D-xylulose; xylose isomerase complement(2140373..2141692) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849662 YP_001054594.1 CDS xylF NC_009053.1 2141946 2142944 D periplasmic substrate-binding component of the ATP-dependent xylose transport system; high affinity; D-xylose transporter subunit XylF 2141946..2142944 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850411 YP_001054595.1 CDS xylG NC_009053.1 2143008 2144522 D with XylFH is part of the high affinity xylose ABC transporter; xylose transporter ATP-binding subunit 2143008..2144522 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850412 YP_001054596.1 CDS xylH NC_009053.1 2144526 2145653 D xylose transport system permease xylH 2144526..2145653 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849893 YP_001054597.1 CDS xylR NC_009053.1 2145778 2146959 D xylose operon regulatory protein 2145778..2146959 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849894 YP_001054598.1 CDS pepO NC_009053.1 2146964 2148991 D neutral endopeptidase 2146964..2148991 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849895 YP_001054599.1 CDS APL_1914 NC_009053.1 2149066 2149293 D hypothetical protein 2149066..2149293 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849896 YP_001054600.1 CDS panF NC_009053.1 2149362 2150774 R mediates high affinitiy panthothenate transport which is stimulated by the presence of sodium ions; member of SSS family of sodium/solute symporters; the imported panthothenate is phosphorylated by panthothenate kinase; sodium/panthothenate symporter complement(2149362..2150774) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849897 YP_001054601.1 CDS ap2048 NC_009053.1 2150794 2151018 R hypothetical protein complement(2150794..2151018) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848626 YP_001054602.1 CDS metJ NC_009053.1 2151070 2151387 R when combined with S-adenosylmethionine represses the expression of the methionine regulon and of proteins involved in S-adenosylmethionine synthesis; transcriptional repressor protein MetJ complement(2151070..2151387) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848627 YP_001054603.1 CDS vacJ NC_009053.1 2151556 2152305 D lipoprotein VacJ-like protein 2151556..2152305 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848628 YP_001054604.1 CDS APL_1919 NC_009053.1 2152380 2153189 D hypothetical protein 2152380..2153189 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848629 YP_001054605.1 CDS APL_1920 NC_009053.1 2153314 2155281 D site-specific recombinase 2153314..2155281 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848630 YP_001054606.1 CDS pgaA NC_009053.1 2156031 2158523 D biofilm PGA synthesis protein PgaA 2156031..2158523 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848631 YP_001054607.1 CDS pgaB NC_009053.1 2158538 2160310 D biofilm PGA synthesis lipoprotein PgaB 2158538..2160310 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848632 YP_001054608.1 CDS pgaC NC_009053.1 2160319 2161554 D predicted polysaccharide polymerase involved in biofilm formation; required for the synthesis of the beta-1,6-N-acetylglucosamine polysaccharide; PgaC; in Yersinia the HmsR protein is an inner membrane protein; N-glycosyltransferase 2160319..2161554 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848633 YP_001054609.1 CDS pgaD NC_009053.1 2161556 2161840 D biofilm PGA synthesis protein pgaD 2161556..2161840 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848634 YP_001054610.1 CDS tpiA NC_009053.1 2161944 2162714 R Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate; triosephosphate isomerase complement(2161944..2162714) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848635 YP_001054611.1 CDS truD NC_009053.1 2162989 2164002 D catalyzes the modification of U13 in tRNA(Glu); tRNA pseudouridine synthase D 2162989..2164002 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848636 YP_001054612.1 CDS surE NC_009053.1 2164002 2164766 D catalyzes the conversion of a phosphate monoester to an alcohol and a phosphate; stationary phase survival protein SurE 2164002..2164766 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849446 YP_001054613.1 CDS APL_1928 NC_009053.1 2164766 2165350 D hypothetical protein 2164766..2165350 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849447 YP_001054614.1 CDS APL_1929 NC_009053.1 2165362 2165937 D lipoprotein 2165362..2165937 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849448 YP_001054615.1 CDS APL_1930 NC_009053.1 2166254 2167492 D Outer membrane antigenic lipoprotein B 2166254..2167492 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849449 YP_001054616.1 CDS tagI NC_009053.1 2167581 2168144 D 3-methyladenine DNA glycosylase 2167581..2168144 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849450 YP_001054617.1 CDS APL_1934 NC_009053.1 2169338 2169802 R hypothetical protein complement(2169338..2169802) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849452 YP_001054618.1 CDS APL_1935 NC_009053.1 2169799 2170224 R hypothetical protein complement(2169799..2170224) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849453 YP_001054619.1 CDS APL_1936 NC_009053.1 2170294 2170437 R hypothetical protein complement(2170294..2170437) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849454 YP_001054620.1 CDS hemH NC_009053.1 2170615 2171574 R ferrochelatase complement(2170615..2171574) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850278 YP_001054621.1 CDS rpmH NC_009053.1 2171850 2171984 D in Escherichia coli transcription of this gene is enhanced by polyamines; 50S ribosomal protein L34 2171850..2171984 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850279 YP_001054622.1 CDS rnpA NC_009053.1 2172077 2172379 D protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates; ribonuclease P 2172077..2172379 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850280 YP_001054623.1 CDS APL_1940 NC_009053.1 2172340 2172642 D hypothetical protein 2172340..2172642 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850281 YP_001054624.1 CDS glnA NC_009053.1 2172693 2174108 R glutamine synthetase complement(2172693..2174108) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850282 YP_001054625.1 CDS icc NC_009053.1 2174466 2175293 R cyclic 3',5'-adenosine monophosphate phosphodiesterase complement(2174466..2175293) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850283 YP_001054626.1 CDS APL_1943 NC_009053.1 2175500 2176123 R ADP-ribose pyrophosphatase complement(2175500..2176123) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850284 YP_001054627.1 CDS APL_1944 NC_009053.1 2176133 2176552 R phosphate-starvation-inducible protein PsiE complement(2176133..2176552) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850285 YP_001054628.1 CDS APL_1945 NC_009053.1 2176545 2177273 R hypothetical protein complement(2176545..2177273) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850286 YP_001054629.1 CDS APL_1946 NC_009053.1 2177333 2177761 R hypothetical protein complement(2177333..2177761) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850287 YP_001054630.1 CDS nhaA NC_009053.1 2177937 2179121 D exports sodium by using the electrochemical proton gradient to allow protons into the cell; functions in adaptation to high salinity and alkaline pH; activity increases at higher pH; downregulated at acidic pH; pH-dependent sodium/proton antiporter 2177937..2179121 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848576 YP_001054631.1 CDS APL_1948 NC_009053.1 2179264 2179752 D hypothetical protein 2179264..2179752 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848577 YP_001054632.1 CDS dtd NC_009053.1 2179788 2180222 R hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine; D-tyrosyl-tRNA(Tyr) deacylase complement(2179788..2180222) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848578 YP_001054633.1 CDS rbn NC_009053.1 2180219 2181049 R RNase BN; required for 3' maturation of certain phage T4-encoded tRNAs; forms a dimer; specific for immature tRNA substrates containing incorrect residues within the universal CCA sequence; 3' to 5' exoribonuclease; ribonuclease BN complement(2180219..2181049) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848579 YP_001054634.1 CDS proA NC_009053.1 2181067 2182305 R Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway; gamma-glutamyl phosphate reductase complement(2181067..2182305) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848580 YP_001054635.1 CDS APL_1956 NC_009053.1 2184989 2185945 R hypothetical protein complement(2184989..2185945) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848582 YP_001054636.1 CDS APL_1957 NC_009053.1 2185963 2187207 R Lipoprotein_5 domain-containing protein complement(2185963..2187207) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848583 YP_001054637.1 CDS mutL NC_009053.1 2187521 2189389 D This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex; DNA mismatch repair protein 2187521..2189389 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848584 YP_001054638.1 CDS adhI NC_009053.1 2189591 2190640 D similar to zinc-dependent eukaryotic ADH enzymes and distinct from fermentative ADHs; alcohol dehydrogenase 2189591..2190640 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848585 YP_001054639.1 CDS miaA NC_009053.1 2190802 2191716 D IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity; tRNA delta(2)-isopentenylpyrophosphate transferase 2190802..2191716 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849962 YP_001054640.1 CDS hfq NC_009053.1 2191781 2192059 D RNA-binding protein Hfq 2191781..2192059 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849963 YP_001054641.1 CDS hflX NC_009053.1 2192241 2193464 D GTP-binding protein hflX 2192241..2193464 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849964 YP_001054642.1 CDS APL_1963 NC_009053.1 2193500 2194060 R hypothetical protein complement(2193500..2194060) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849965 YP_001054643.1 CDS APL_1964 NC_009053.1 2194123 2194446 D hypothetical protein 2194123..2194446 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849966 YP_001054644.1 CDS crp NC_009053.1 2194502 2195182 R complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons; cAMP-regulatory protein complement(2194502..2195182) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849967 YP_001054645.1 CDS APL_1966 NC_009053.1 2195254 2195472 R hypothetical protein complement(2195254..2195472) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849968 YP_001054646.1 CDS slmA NC_009053.1 2195478 2196086 R FtsZ binding protein; synthetically lethal with a defect in the Min system; this protein is the first identified nucleoid occlusion factor which works along with the Min system to properly position the FtsZ ring assembly; nucleoid occlusion protein complement(2195478..2196086) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849969 YP_001054647.1 CDS dut NC_009053.1 2196192 2196647 R catalyzes the formation of dUMP from dUTP; deoxyuridine 5'-triphosphate nucleotidohydrolase complement(2196192..2196647) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849970 YP_001054648.1 CDS dfp NC_009053.1 2196656 2197861 R catalyzes the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, which is then decarboxylated to form 4'-phosphopantotheine; bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase complement(2196656..2197861) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849971 YP_001054649.1 CDS radC NC_009053.1 2198069 2198731 D Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase; DNA repair protein RadC 2198069..2198731 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848589 YP_001054650.1 CDS rpmB NC_009053.1 2198900 2199136 D required for 70S ribosome assembly; 50S ribosomal protein L28 2198900..2199136 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848590 YP_001054651.1 CDS rpmG NC_009053.1 2199148 2199318 D in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 2199148..2199318 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848591 YP_001054652.1 CDS APL_1973 NC_009053.1 2199731 2200291 D hypothetical protein 2199731..2200291 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848592 YP_001054653.1 CDS argD NC_009053.1 2200641 2201936 D catalyzes the reversible formation of diaminobutyrate and 2-oxoglutarate from glutamate and L-aspartic beta-semialdehyde; diaminobutyrate--2-oxoglutarate aminotransferase 2200641..2201936 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848593 YP_001054654.1 CDS ddc NC_009053.1 2202065 2203600 D L-2,4-diaminobutyrate decarboxylase 2202065..2203600 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848594 YP_001054655.1 CDS yedF NC_009053.1 2203659 2203928 R hypothetical protein complement(2203659..2203928) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848595 YP_001054656.1 CDS yedE NC_009053.1 2203946 2205166 R inner membrane protein complement(2203946..2205166) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848596 YP_001054657.1 CDS APL_1978 NC_009053.1 2205462 2205794 D hypothetical protein 2205462..2205794 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848597 YP_001054658.1 CDS trmA NC_009053.1 2205957 2207063 D catalyzes the formation of 5-methyl-uridine at position 54 in all tRNAs; tRNA (uracil-5-)-methyltransferase 2205957..2207063 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848598 YP_001054659.1 CDS APL_1980 NC_009053.1 2207584 2208186 R hypothetical protein complement(2207584..2208186) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849530 YP_001054660.1 CDS corA NC_009053.1 2208647 2209600 R responsible for the influx of magnesium ions; magnesium/nickel/cobalt transporter CorA complement(2208647..2209600) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849531 YP_001054661.1 CDS ubiE NC_009053.1 2209901 2210677 D ubiquinone/menaquinone biosynthesis methyltransferase ubiE 2209901..2210677 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849532 YP_001054662.1 CDS APL_1983 NC_009053.1 2210703 2211335 D hypothetical protein 2210703..2211335 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849533 YP_001054663.1 CDS ubiB NC_009053.1 2211332 2212966 D ubiquinone biosynthesis protein ubiB 2211332..2212966 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849534 YP_001054664.1 CDS tatA NC_009053.1 2213058 2213288 D TatA; similar to TatE that is found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes; twin arginine translocase protein A 2213058..2213288 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849535 YP_001054665.1 CDS tatB NC_009053.1 2213292 2213879 D mediates the export of protein precursors bearing twin-arginine signal peptides; sec-independent translocase 2213292..2213879 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849536 YP_001054666.1 CDS tatC NC_009053.1 2214043 2214615 D Sec-independent protein translocase protein tatC 2214043..2214615 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850092 YP_001054667.1 CDS hemB NC_009053.1 2214675 2215694 D catalyzes the formation of porphobilinogen from 5-aminolevulinate; delta-aminolevulinic acid dehydratase 2214675..2215694 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850093 YP_001054668.1 CDS APL_1989 NC_009053.1 2215781 2216143 D hypothetical protein 2215781..2216143 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850094 YP_001054669.1 CDS mutM NC_009053.1 2216194 2217015 R Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases; formamidopyrimidine-DNA glycosylase complement(2216194..2217015) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850095 YP_001054670.1 CDS brnQ NC_009053.1 2217078 2218370 R branched chain amino acid ABC transporter carrier protein complement(2217078..2218370) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850096 YP_001054671.1 CDS fabG NC_009053.1 2218496 2219221 R catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase complement(2218496..2219221) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850097 YP_001054672.1 CDS fabD NC_009053.1 2219340 2220275 R malonyl CoA-acyl carrier protein transacylase complement(2219340..2220275) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850098 YP_001054673.1 CDS APL_1994 NC_009053.1 2220342 2221088 R hypothetical protein complement(2220342..2221088) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850099 YP_001054674.1 CDS ispB NC_009053.1 2221125 2222120 R octaprenyl-diphosphate synthase complement(2221125..2222120) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850100 YP_001054675.1 CDS rssA NC_009053.1 2222409 2223227 D hypothetical protein 2222409..2223227 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850101 YP_001054676.1 CDS APL_1997 NC_009053.1 2223391 2223942 D hypothetical protein 2223391..2223942 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848813 YP_001054677.1 CDS APL_1998 NC_009053.1 2224143 2224556 D hypothetical protein 2224143..2224556 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848814 YP_001054678.1 CDS rplU NC_009053.1 2224909 2225220 D 50S ribosomal protein L21 2224909..2225220 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848815 YP_001054679.1 CDS rpmA NC_009053.1 2225241 2225498 D involved in the peptidyltransferase reaction during translation; 50S ribosomal protein L27 2225241..2225498 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848816 YP_001054680.1 CDS APL_2001 NC_009053.1 2225578 2226522 D hypothetical protein 2225578..2226522 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848817 YP_001054681.1 CDS APL_2002 NC_009053.1 2226751 2228220 R hypothetical protein complement(2226751..2228220) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848818 YP_001054682.1 CDS ap2140 NC_009053.1 2228336 2229145 R hypothetical protein complement(2228336..2229145) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848819 YP_001054683.1 CDS comF NC_009053.1 2229265 2229942 D competence protein F 2229265..2229942 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848820 YP_001054684.1 CDS rsmC NC_009053.1 2230377 2231366 R 16S rRNA M2G1207 methyltransferase; one of many enzymes that modify bases of the ribosomal RNA; this enzyme methylates the G at position 1207 of the small ribosomal subunit; 16S ribosomal RNA m2G1207 methyltransferase complement(2230377..2231366) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848821 YP_001054685.1 CDS holD NC_009053.1 2231501 2231893 D with the chi subunit binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB; DNA polymerase III subunit psi 2231501..2231893 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848822 YP_001054686.1 CDS rimI NC_009053.1 2231886 2232323 D alanine acetyltransferase that specifically acetylates ribosomal protein S18; ribosomal-protein-alanine N-acetyltransferase 2231886..2232323 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850508 YP_001054687.1 CDS srmB NC_009053.1 2232346 2233683 D facilitates an early step in the assembly of the 50S subunit of the ribosome; ATP-dependent RNA helicase SrmB 2232346..2233683 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850509 YP_001054688.1 CDS pdxH NC_009053.1 2233758 2234387 D catalyzes the formation of pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate; pyridoxamine 5'-phosphate oxidase 2233758..2234387 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850510 YP_001054689.1 CDS hbpA NC_009053.1 2234459 2236096 R heme-binding protein A complement(2234459..2236096) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850511 YP_001054690.1 CDS aldA NC_009053.1 2236287 2237768 R aldehyde dehydrogenase aldA complement(2236287..2237768) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850512 YP_001054691.1 CDS APL_2012 NC_009053.1 2237974 2238543 R hypothetical protein complement(2237974..2238543) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850513 YP_001054692.1 CDS fhuC NC_009053.1 2238869 2239549 D ferrichrome ABC transporter ATP-binding protein 2238869..2239549 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850514 YP_001054693.1 CDS APL_2014 NC_009053.1 2239666 2240505 D similar to Haemophilus parasuis FhuD; ABC-type Fe3+-hydroxamate transport system, periplasmic component; FhuD 2239666..2240505 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850515 YP_001054694.1 CDS fhuB NC_009053.1 2240499 2242451 D part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter involved in the high-affinity transport of Fe(3+)-ferrichrome; iron-hydroxamate transporter permease subunit 2240499..2242451 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850516 YP_001054695.1 CDS APL_2016 NC_009053.1 2242636 2244489 D ferrioxamine B receptor 2242636..2244489 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850517 YP_001054696.1 CDS APL_2017 NC_009053.1 2244556 2244873 D hypothetical protein 2244556..2244873 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850115 YP_001054697.1 CDS purC NC_009053.1 2244964 2245821 R catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase; phosphoribosylaminoimidazolesuccinocarboxamide synthase complement(2244964..2245821) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850116 YP_001054698.1 CDS hisG NC_009053.1 2246191 2247090 D long form of enzyme; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms active dimers and inactive hexamers which is dependent on concentration of substrates and inhibitors; ATP phosphoribosyltransferase 2246191..2247090 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850117 YP_001054699.1 CDS hisD NC_009053.1 2247206 2248492 D catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer; histidinol dehydrogenase 2247206..2248492 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850118 YP_001054700.1 CDS hisC NC_009053.1 2248616 2249668 D catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis; histidinol-phosphate aminotransferase 2248616..2249668 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850119 YP_001054701.1 CDS APL_2022 NC_009053.1 2249794 2250234 D transposase IS200 2249794..2250234 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850120 YP_001054702.1 CDS hisB NC_009053.1 2250366 2251457 D catalyzes the formation of 3-(imidazol-4-yl)-2-oxopropyl phosphate from D-ethythro-1-(imidazol-4-yl)glycerol 3-phosphate and histidinol from histidinol phosphate; imidazole glycerol-phosphate dehydratase/histidinol phosphatase 2250366..2251457 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850121 YP_001054703.1 CDS APL_2024 NC_009053.1 2252274 2253059 D hypothetical protein 2252274..2253059 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850122 YP_001054704.1 CDS hisH NC_009053.1 2253185 2253775 D with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide; imidazole glycerol phosphate synthase subunit HisH 2253185..2253775 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850123 YP_001054705.1 CDS hisA NC_009053.1 2253896 2254648 D catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide; 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase 2253896..2254648 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850124 YP_001054706.1 CDS hisF NC_009053.1 2254771 2255403 D imidazole glycerol phosphate synthase subunit HisF 2254771..2255403 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849042 YP_001054707.1 CDS hisI NC_009053.1 2255532 2256176 D catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribosyl)-ATP and the subsequent formation of 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide from 1-(5-phosphoribosyl)-AMP in histidine biosynthesis; bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase 2255532..2256176 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849043 YP_001054708.1 CDS APL_2029 NC_009053.1 2256297 2256962 D hypothetical protein 2256297..2256962 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849044 YP_001054709.1 CDS map NC_009053.1 2257069 2257875 D catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn; methionine aminopeptidase 2257069..2257875 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849045 YP_001054710.1 CDS APL_2031 NC_009053.1 2257942 2258436 R hypothetical protein complement(2257942..2258436) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849046 YP_001054711.1 CDS scrR NC_009053.1 2258469 2259488 R sucrose operon repressor (Scr operon regulatory protein) complement(2258469..2259488) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849047 YP_001054712.1 CDS scrB NC_009053.1 2259559 2260995 R sucrose-6-phosphate hydrolase (Sucrase) (invertase) complement(2259559..2260995) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849048 YP_001054713.1 CDS scrK NC_009053.1 2261049 2261972 R phosphorylates aminoimidazole ribotide (AIR) which forms 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate (HMP-P); synthesis of HMP-P from AIR is complex and requires the product of thiC gene at least; aminoimidazole riboside kinase complement(2261049..2261972) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849049 YP_001054714.1 CDS sufI NC_009053.1 2262184 2263194 D copper-containing nitrite reductase 2262184..2263194 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849050 YP_001054715.1 CDS lolE NC_009053.1 2263265 2264515 R part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane; outer membrane-specific lipoprotein transporter subunit LolE complement(2263265..2264515) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849051 YP_001054716.1 CDS lolD NC_009053.1 2264515 2265228 R lipoprotein-releasing system ATP-binding protein lolD complement(2264515..2265228) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848904 YP_001054717.1 CDS lolC NC_009053.1 2265296 2266468 R lipoprotein-releasing system transmembrane protein lolC complement(2265296..2266468) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848905 YP_001054718.1 CDS ldhA NC_009053.1 2266593 2267543 R Catalyzes the reduction of hydroxypyruvate to form D-glycerate, using NADH as an electron donor; glycerate dehydrogenase complement(2266593..2267543) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848906 YP_001054719.1 CDS kdsA NC_009053.1 2267599 2268453 R catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis; 2-dehydro-3-deoxyphosphooctonate aldolase complement(2267599..2268453) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848907 YP_001054720.1 CDS APL_2041 NC_009053.1 2268504 2269370 R hypothetical protein complement(2268504..2269370) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848908 YP_001054721.1 CDS hemK NC_009053.1 2269371 2270243 R similar to M.PmuHemKP; HemK-like protein complement(2269371..2270243) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848909 YP_001054722.1 CDS APL_2043 NC_009053.1 2270245 2270772 R hypothetical protein complement(2270245..2270772) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848910 YP_001054723.1 CDS prfA NC_009053.1 2270835 2271836 R recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2; peptide chain release factor 1 complement(2270835..2271836) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848911 YP_001054724.1 CDS sseA NC_009053.1 2272069 2273439 R thiosulfate sulfurtransferase complement(2272069..2273439) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848912 YP_001054725.1 CDS APL_2046 NC_009053.1 2273448 2274440 R hypothetical protein complement(2273448..2274440) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848913 APL_2047 tRNA APL_2047 NC_009053.1 70978 71054 D tRNA-Ile 70978..71054 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850394 APL_2048 tRNA APL_2048 NC_009053.1 71106 71181 D tRNA-Ala 71106..71181 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848520 APL_2049 tRNA APL_2049 NC_009053.1 253764 253853 D tRNA-Ser 253764..253853 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850341 APL_2050 tRNA APL_2050 NC_009053.1 280422 280497 D tRNA-Glu 280422..280497 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849318 APL_2051 tRNA APL_2051 NC_009053.1 346228 346303 D tRNA-Asn 346228..346303 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850047 APL_2052 tRNA APL_2052 NC_009053.1 488229 488305 D tRNA-Met 488229..488305 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848936 APL_2053 tRNA APL_2053 NC_009053.1 727971 728047 D tRNA-Met 727971..728047 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850476 APL_2108 tRNA APL_2108 NC_009053.1 848550 848635 R tRNA-Leu complement(848550..848635) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850176 APL_2054 tRNA APL_2054 NC_009053.1 870793 870869 D tRNA-Val 870793..870869 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849376 APL_2107 tRNA APL_2107 NC_009053.1 883530 883603 R tRNA-Cys complement(883530..883603) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849220 APL_2106 tRNA APL_2106 NC_009053.1 883621 883696 R tRNA-Gly complement(883621..883696) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848667 APL_2055 tRNA APL_2055 NC_009053.1 943487 943563 D tRNA-Met 943487..943563 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849597 APL_2056 tRNA APL_2056 NC_009053.1 945401 945486 D tRNA-Leu 945401..945486 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850070 APL_2105 tRNA APL_2105 NC_009053.1 1039391 1039467 R tRNA-Arg complement(1039391..1039467) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850528 APL_2104 tRNA APL_2104 NC_009053.1 1039511 1039587 R tRNA-Pro complement(1039511..1039587) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848462 APL_2103 tRNA APL_2103 NC_009053.1 1315346 1315420 R tRNA-Gln complement(1315346..1315420) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850521 APL_2102 tRNA APL_2102 NC_009053.1 1315469 1315543 R tRNA-Gln complement(1315469..1315543) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848797 APL_2101 tRNA APL_2101 NC_009053.1 1315592 1315666 R tRNA-Gln complement(1315592..1315666) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850038 APL_2100 tRNA APL_2100 NC_009053.1 1315692 1315776 R tRNA-Leu complement(1315692..1315776) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849250 APL_2099 tRNA APL_2099 NC_009053.1 1315780 1315856 R tRNA-Met complement(1315780..1315856) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849427 APL_2098 tRNA APL_2098 NC_009053.1 1466083 1466158 R tRNA-Val complement(1466083..1466158) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848845 APL_2097 tRNA APL_2097 NC_009053.1 1466209 1466284 R tRNA-Val complement(1466209..1466284) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849843 APL_2096 tRNA APL_2096 NC_009053.1 1466335 1466410 R tRNA-Val complement(1466335..1466410) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850428 APL_2095 tRNA APL_2095 NC_009053.1 1466458 1466533 R tRNA-Val complement(1466458..1466533) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849182 APL_2057 tRNA APL_2057 NC_009053.1 1468226 1468301 D tRNA-Ala 1468226..1468301 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848652 APL_2094 tRNA APL_2094 NC_009053.1 1472847 1472923 R tRNA-Asp complement(1472847..1472923) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850226 APL_2093 tRNA APL_2093 NC_009053.1 1472965 1473041 R tRNA-Asp complement(1472965..1473041) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848932 APL_2092 tRNA APL_2092 NC_009053.1 1534654 1534729 R tRNA-Gly complement(1534654..1534729) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850460 APL_2091 tRNA APL_2091 NC_009053.1 1534776 1534862 R tRNA-Leu complement(1534776..1534862) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849740 APL_2090 tRNA APL_2090 NC_009053.1 1534895 1534981 R tRNA-Leu complement(1534895..1534981) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850303 APL_2089 tRNA APL_2089 NC_009053.1 1535004 1535079 R tRNA-Gly complement(1535004..1535079) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849388 APL_2088 tRNA APL_2088 NC_009053.1 1535106 1535192 R tRNA-Leu complement(1535106..1535192) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849783 APL_2087 tRNA APL_2087 NC_009053.1 1535204 1535279 R tRNA-Gly complement(1535204..1535279) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848941 APL_2086 tRNA APL_2086 NC_009053.1 1563896 1563972 R tRNA-Arg complement(1563896..1563972) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849584 APL_2085 tRNA APL_2085 NC_009053.1 1564045 1564121 R tRNA-Arg complement(1564045..1564121) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849412 APL_2084 tRNA APL_2084 NC_009053.1 1564135 1564229 R tRNA-Ser complement(1564135..1564229) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849262 APL_2083 tRNA APL_2083 NC_009053.1 1574010 1574085 R tRNA-Ala complement(1574010..1574085) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850191 APL_2082 tRNA APL_2082 NC_009053.1 1574137 1574213 R tRNA-Ile complement(1574137..1574213) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850466 APL_2058 tRNA APL_2058 NC_009053.1 1700890 1700965 D tRNA-Thr 1700890..1700965 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849456 APL_2081 tRNA APL_2081 NC_009053.1 1729277 1729352 R tRNA-Thr complement(1729277..1729352) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850140 APL_2080 tRNA APL_2080 NC_009053.1 1729356 1729430 R tRNA-Gly complement(1729356..1729430) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850153 APL_2079 tRNA APL_2079 NC_009053.1 1729475 1729559 R tRNA-Tyr complement(1729475..1729559) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850315 APL_2078 tRNA APL_2078 NC_009053.1 1729596 1729671 R tRNA-Thr complement(1729596..1729671) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848994 APL_2077 tRNA APL_2077 NC_009053.1 1757569 1757644 R tRNA-Trp complement(1757569..1757644) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849132 APL_2076 tRNA APL_2076 NC_009053.1 1757694 1757770 R tRNA-Asp complement(1757694..1757770) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849133 APL_2075 tRNA APL_2075 NC_009053.1 1761302 1761377 R tRNA-Glu complement(1761302..1761377) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848544 APL_2074 tRNA APL_2074 NC_009053.1 1763559 1763635 R tRNA-Pro complement(1763559..1763635) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849319 APL_2073 tRNA APL_2073 NC_009053.1 1763664 1763739 R tRNA-His complement(1763664..1763739) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849694 APL_2072 tRNA APL_2072 NC_009053.1 1763770 1763846 R tRNA-Arg complement(1763770..1763846) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849994 APL_2059 tRNA APL_2059 NC_009053.1 1788731 1788821 D tRNA-Sec 1788731..1788821 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849483 APL_2071 tRNA APL_2071 NC_009053.1 1871046 1871121 R tRNA-Ala complement(1871046..1871121) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850333 APL_2070 tRNA APL_2070 NC_009053.1 1871173 1871249 R tRNA-Ile complement(1871173..1871249) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850006 APL_2060 tRNA APL_2060 NC_009053.1 1977086 1977161 D tRNA-Phe 1977086..1977161 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850151 APL_2061 tRNA APL_2061 NC_009053.1 1977167 1977242 D tRNA-Asn 1977167..1977242 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848825 APL_2062 tRNA APL_2062 NC_009053.1 1977375 1977450 D tRNA-Phe 1977375..1977450 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848918 APL_2063 tRNA APL_2063 NC_009053.1 1977456 1977531 D tRNA-Asn 1977456..1977531 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849366 APL_2069 tRNA APL_2069 NC_009053.1 2041483 2041558 R tRNA-Lys complement(2041483..2041558) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850005 APL_2068 tRNA APL_2068 NC_009053.1 2041593 2041668 R tRNA-Lys complement(2041593..2041668) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848603 APL_2067 tRNA APL_2067 NC_009053.1 2041692 2041767 R tRNA-Lys complement(2041692..2041767) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850056 APL_2064 tRNA APL_2064 NC_009053.1 2067372 2067447 D tRNA-Glu 2067372..2067447 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850445 APL_2065 tRNA APL_2065 NC_009053.1 2207169 2207258 D tRNA-Ser 2207169..2207258 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849528 APL_2066 tRNA APL_2066 NC_009053.1 2207342 2207431 D tRNA-Ser 2207342..2207431 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849529 APL_2109 rRNA APL_2109 NC_009053.1 69354 70891 D 16S ribosomal RNA 69354..70891 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848465 APL_2115 rRNA APL_2115 NC_009053.1 71448 74342 D 23S ribosomal RNA 71448..74342 Actinobacillus pleuropneumoniae serovar 5b str. L20 4848470 APL_2121 rRNA APL_2121 NC_009053.1 74508 74626 D 5S ribosomal RNA 74508..74626 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849956 APL_2116 rRNA APL_2116 NC_009053.1 280714 283608 D 23S ribosomal RNA 280714..283608 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849207 APL_2122 rRNA APL_2122 NC_009053.1 283776 283894 D 5S ribosomal RNA 283776..283894 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849669 APL_2123 rRNA APL_2123 NC_009053.1 1570566 1570683 R 5S ribosomal RNA complement(1570566..1570683) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849279 APL_2117 rRNA APL_2117 NC_009053.1 1570844 1573747 R 23S ribosomal RNA complement(1570844..1573747) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849127 APL_2111 rRNA APL_2111 NC_009053.1 1574295 1575837 R 16S ribosomal RNA complement(1574295..1575837) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850007 APL_2124 rRNA APL_2124 NC_009053.1 1757783 1757899 R 5S ribosomal RNA complement(1757783..1757899) Actinobacillus pleuropneumoniae serovar 5b str. L20 4849577 APL_2124a rRNA APL_2124a NC_009053.1 1757954 1758072 R 5S ribosomal RNA complement(1757954..1758072) Actinobacillus pleuropneumoniae serovar 5b str. L20 5309707 APL_2118 rRNA APL_2118 NC_009053.1 1758184 1761087 R 23S ribosomal RNA complement(1758184..1761087) Actinobacillus pleuropneumoniae serovar 5b str. L20 4850364 APL_2125 rRNA APL_2125 NC_009053.1 1867605 1867719 R 5S ribosomal RNA complement(1867605..1867719) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848535 APL_2119 rRNA APL_2119 NC_009053.1 1867880 1870783 R 23S ribosomal RNA complement(1867880..1870783) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848712 APL_2113 rRNA APL_2113 NC_009053.1 1871331 1872873 R 16S ribosomal RNA complement(1871331..1872873) Actinobacillus pleuropneumoniae serovar 5b str. L20 4848744 APL_2120 rRNA APL_2120 NC_009053.1 2067662 2070566 D 23S ribosomal RNA 2067662..2070566 Actinobacillus pleuropneumoniae serovar 5b str. L20 4850487 APL_2126 rRNA APL_2126 NC_009053.1 2070727 2070844 D 5S ribosomal RNA 2070727..2070844 Actinobacillus pleuropneumoniae serovar 5b str. L20 4849726