-- dump date 20140618_191234 -- class Genbank::misc_feature -- table misc_feature_note -- id note 696748000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 696748000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 696748000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 696748000004 Walker B motif; other site 696748000005 arginine finger; other site 696748000006 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 696748000007 DnaA box-binding interface [nucleotide binding]; other site 696748000008 DNA polymerase III subunit beta; Validated; Region: PRK05643 696748000009 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 696748000010 putative DNA binding surface [nucleotide binding]; other site 696748000011 dimer interface [polypeptide binding]; other site 696748000012 beta-clamp/clamp loader binding surface; other site 696748000013 beta-clamp/translesion DNA polymerase binding surface; other site 696748000014 recF protein; Region: recf; TIGR00611 696748000015 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 696748000016 Walker A/P-loop; other site 696748000017 ATP binding site [chemical binding]; other site 696748000018 Q-loop/lid; other site 696748000019 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 696748000020 ABC transporter signature motif; other site 696748000021 Walker B; other site 696748000022 D-loop; other site 696748000023 H-loop/switch region; other site 696748000024 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 696748000025 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 696748000026 E-class dimer interface [polypeptide binding]; other site 696748000027 P-class dimer interface [polypeptide binding]; other site 696748000028 active site 696748000029 Cu2+ binding site [ion binding]; other site 696748000030 Zn2+ binding site [ion binding]; other site 696748000031 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 696748000032 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 696748000033 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 696748000034 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 696748000035 eyelet of channel; other site 696748000036 trimer interface [polypeptide binding]; other site 696748000037 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 696748000038 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 696748000039 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 696748000040 putative inner membrane peptidase; Provisional; Region: PRK11778 696748000041 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 696748000042 tandem repeat interface [polypeptide binding]; other site 696748000043 oligomer interface [polypeptide binding]; other site 696748000044 active site residues [active] 696748000045 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 696748000046 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 696748000047 DNA binding site [nucleotide binding] 696748000048 catalytic residue [active] 696748000049 H2TH interface [polypeptide binding]; other site 696748000050 putative catalytic residues [active] 696748000051 turnover-facilitating residue; other site 696748000052 intercalation triad [nucleotide binding]; other site 696748000053 8OG recognition residue [nucleotide binding]; other site 696748000054 putative reading head residues; other site 696748000055 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 696748000056 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 696748000057 Branched-chain amino acid permeases [Amino acid transport and metabolism]; Region: BrnQ; COG1114 696748000058 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 696748000059 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 696748000060 NAD(P) binding site [chemical binding]; other site 696748000061 homotetramer interface [polypeptide binding]; other site 696748000062 homodimer interface [polypeptide binding]; other site 696748000063 active site 696748000064 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 696748000065 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 696748000066 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 696748000067 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 696748000068 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 696748000069 substrate binding pocket [chemical binding]; other site 696748000070 chain length determination region; other site 696748000071 substrate-Mg2+ binding site; other site 696748000072 catalytic residues [active] 696748000073 aspartate-rich region 1; other site 696748000074 active site lid residues [active] 696748000075 aspartate-rich region 2; other site 696748000076 Predicted flavoprotein [General function prediction only]; Region: COG0431 696748000077 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 696748000078 Predicted membrane protein [Function unknown]; Region: COG2259 696748000079 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 696748000080 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 696748000081 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 696748000082 EamA-like transporter family; Region: EamA; pfam00892 696748000083 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 696748000084 EamA-like transporter family; Region: EamA; pfam00892 696748000085 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 696748000086 cytidine deaminase; Provisional; Region: PRK09027 696748000087 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 696748000088 active site 696748000089 catalytic motif [active] 696748000090 Zn binding site [ion binding]; other site 696748000091 Cytidine and deoxycytidylate deaminase zinc-binding region; Region: dCMP_cyt_deam_2; pfam08211 696748000092 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 696748000093 EamA-like transporter family; Region: EamA; pfam00892 696748000094 EamA-like transporter family; Region: EamA; pfam00892 696748000095 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 696748000096 homooctamer interface [polypeptide binding]; other site 696748000097 active site 696748000098 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 696748000099 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 696748000100 nucleophilic elbow; other site 696748000101 catalytic triad; other site 696748000102 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 696748000103 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 696748000104 dimerization interface [polypeptide binding]; other site 696748000105 domain crossover interface; other site 696748000106 redox-dependent activation switch; other site 696748000107 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 696748000108 RNA binding surface [nucleotide binding]; other site 696748000109 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 696748000110 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 696748000111 dimer interface [polypeptide binding]; other site 696748000112 ADP-ribose binding site [chemical binding]; other site 696748000113 active site 696748000114 nudix motif; other site 696748000115 metal binding site [ion binding]; metal-binding site 696748000116 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 696748000117 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 696748000118 active site 696748000119 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 696748000120 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 696748000121 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 696748000122 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 696748000123 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 696748000124 putative active site [active] 696748000125 benzoate transport; Region: 2A0115; TIGR00895 696748000126 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696748000127 putative substrate translocation pore; other site 696748000128 potential frameshift: common BLAST hit: gi|190150628|ref|YP_001969153.1| aspartate racemase 696748000129 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG0362 696748000130 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 696748000131 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 696748000132 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 696748000133 putative sulfate transport protein CysZ; Validated; Region: PRK04949 696748000134 cell division protein ZipA; Provisional; Region: PRK01741 696748000135 ZipA, C-terminal FtsZ-binding domain; Region: ZipA_C; pfam04354 696748000136 FtsZ protein binding site [polypeptide binding]; other site 696748000137 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 696748000138 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 696748000139 nucleotide binding pocket [chemical binding]; other site 696748000140 K-X-D-G motif; other site 696748000141 catalytic site [active] 696748000142 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 696748000143 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 696748000144 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 696748000145 Dimer interface [polypeptide binding]; other site 696748000146 BRCT sequence motif; other site 696748000147 tyrosine kinase; Provisional; Region: PRK11519 696748000148 Chain length determinant protein; Region: Wzz; pfam02706 696748000149 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 696748000150 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 696748000151 polysaccharide export protein Wza; Provisional; Region: PRK15078 696748000152 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 696748000153 SLBB domain; Region: SLBB; pfam10531 696748000154 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 696748000155 Bacterial sugar transferase; Region: Bac_transf; pfam02397 696748000156 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 696748000157 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 696748000158 putative ADP-binding pocket [chemical binding]; other site 696748000159 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 696748000160 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 696748000161 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 696748000162 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 696748000163 Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039 696748000164 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 696748000165 UDP-glucose 4-epimerase; Region: PLN02240 696748000166 NAD binding site [chemical binding]; other site 696748000167 homodimer interface [polypeptide binding]; other site 696748000168 active site 696748000169 substrate binding site [chemical binding]; other site 696748000170 muropeptide transporter; Reviewed; Region: ampG; PRK11902 696748000171 AmpG-like permease; Region: 2A0125; TIGR00901 696748000172 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 696748000173 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 696748000174 adenylate kinase; Reviewed; Region: adk; PRK00279 696748000175 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 696748000176 AMP-binding site [chemical binding]; other site 696748000177 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 696748000178 malate dehydrogenase; Provisional; Region: PRK05086 696748000179 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 696748000180 NAD binding site [chemical binding]; other site 696748000181 dimerization interface [polypeptide binding]; other site 696748000182 Substrate binding site [chemical binding]; other site 696748000183 arginine repressor; Provisional; Region: PRK05066 696748000184 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 696748000185 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 696748000186 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696748000187 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 696748000188 NAD(P) binding site [chemical binding]; other site 696748000189 active site 696748000190 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 696748000191 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 696748000192 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 696748000193 protein binding site [polypeptide binding]; other site 696748000194 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 696748000195 protein binding site [polypeptide binding]; other site 696748000196 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 696748000197 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 696748000198 Walker A/P-loop; other site 696748000199 ATP binding site [chemical binding]; other site 696748000200 Q-loop/lid; other site 696748000201 ABC transporter signature motif; other site 696748000202 Walker B; other site 696748000203 D-loop; other site 696748000204 H-loop/switch region; other site 696748000205 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 696748000206 Permease; Region: Permease; cl00510 696748000207 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 696748000208 mce related protein; Region: MCE; pfam02470 696748000209 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; cl01074 696748000210 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 696748000211 anti sigma factor interaction site; other site 696748000212 regulatory phosphorylation site [posttranslational modification]; other site 696748000213 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 696748000214 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 696748000215 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 696748000216 hinge; other site 696748000217 active site 696748000218 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 696748000219 active site residue [active] 696748000220 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 696748000221 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 696748000222 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 696748000223 ABC transporter; Region: ABC_tran_2; pfam12848 696748000224 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 696748000225 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 696748000226 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 696748000227 active site 696748000228 catalytic site [active] 696748000229 substrate binding site [chemical binding]; other site 696748000230 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 696748000231 active site 696748000232 Fe-S metabolism associated domain; Region: SufE; cl00951 696748000233 Clp protease; Region: CLP_protease; pfam00574 696748000234 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 696748000235 oligomer interface [polypeptide binding]; other site 696748000236 active site residues [active] 696748000237 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 696748000238 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 696748000239 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 696748000240 Walker A motif; other site 696748000241 ATP binding site [chemical binding]; other site 696748000242 Walker B motif; other site 696748000243 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 696748000244 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 696748000245 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 696748000246 Uncharacterized conserved protein [Function unknown]; Region: COG2835 696748000247 Domain of unknown function (DUF927); Region: DUF927; cl12098 696748000248 Ash protein family; Region: Phage_ASH; pfam10554 696748000249 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713 696748000250 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3646 696748000251 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 696748000252 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 696748000253 integrase; Provisional; Region: PRK09692 696748000254 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 696748000255 active site 696748000256 Int/Topo IB signature motif; other site 696748000257 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 696748000258 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 696748000259 HIGH motif; other site 696748000260 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 696748000261 active site 696748000262 KMSKS motif; other site 696748000263 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 696748000264 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 696748000265 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 696748000266 FeS/SAM binding site; other site 696748000267 TPR repeat; Region: TPR_11; pfam13414 696748000268 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 696748000269 binding surface 696748000270 TPR motif; other site 696748000271 TPR repeat; Region: TPR_11; pfam13414 696748000272 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 696748000273 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 696748000274 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 696748000275 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 696748000276 RNA binding site [nucleotide binding]; other site 696748000277 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 696748000278 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 696748000279 oligomeric interface; other site 696748000280 putative active site [active] 696748000281 homodimer interface [polypeptide binding]; other site 696748000282 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 696748000283 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 696748000284 hypothetical protein; Provisional; Region: PRK04860 696748000285 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 696748000286 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 696748000287 B1 nucleotide binding pocket [chemical binding]; other site 696748000288 B2 nucleotide binding pocket [chemical binding]; other site 696748000289 CAS motifs; other site 696748000290 active site 696748000291 protease 4; Provisional; Region: PRK10949 696748000292 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 696748000293 tandem repeat interface [polypeptide binding]; other site 696748000294 oligomer interface [polypeptide binding]; other site 696748000295 active site residues [active] 696748000296 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 696748000297 tandem repeat interface [polypeptide binding]; other site 696748000298 oligomer interface [polypeptide binding]; other site 696748000299 active site residues [active] 696748000300 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 696748000301 putative FMN binding site [chemical binding]; other site 696748000302 short chain dehydrogenase; Provisional; Region: PRK05993 696748000303 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 696748000304 NADP binding site [chemical binding]; other site 696748000305 active site 696748000306 steroid binding site; other site 696748000307 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 696748000308 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 696748000309 metal-binding site [ion binding] 696748000310 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 696748000311 Soluble P-type ATPase [General function prediction only]; Region: COG4087 696748000312 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 696748000313 metal-binding site [ion binding] 696748000314 Protein of unknown function, DUF; Region: DUF411; cl01142 696748000315 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 696748000316 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 696748000317 DNA binding residues [nucleotide binding] 696748000318 dimer interface [polypeptide binding]; other site 696748000319 copper binding site [ion binding]; other site 696748000320 PBP superfamily domain; Region: PBP_like_2; cl17296 696748000321 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 696748000322 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 696748000323 eyelet of channel; other site 696748000324 trimer interface [polypeptide binding]; other site 696748000325 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 696748000326 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 696748000327 dimer interface [polypeptide binding]; other site 696748000328 conserved gate region; other site 696748000329 putative PBP binding loops; other site 696748000330 ABC-ATPase subunit interface; other site 696748000331 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 696748000332 fructuronate transporter; Provisional; Region: PRK10034; cl15264 696748000333 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 696748000334 dimer interface [polypeptide binding]; other site 696748000335 conserved gate region; other site 696748000336 putative PBP binding loops; other site 696748000337 ABC-ATPase subunit interface; other site 696748000338 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 696748000339 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 696748000340 Walker A/P-loop; other site 696748000341 ATP binding site [chemical binding]; other site 696748000342 Q-loop/lid; other site 696748000343 ABC transporter signature motif; other site 696748000344 Walker B; other site 696748000345 D-loop; other site 696748000346 H-loop/switch region; other site 696748000347 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 696748000348 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 696748000349 active site 696748000350 phosphorylation site [posttranslational modification] 696748000351 intermolecular recognition site; other site 696748000352 dimerization interface [polypeptide binding]; other site 696748000353 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 696748000354 DNA binding site [nucleotide binding] 696748000355 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 696748000356 PAS domain; Region: PAS; smart00091 696748000357 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 696748000358 dimer interface [polypeptide binding]; other site 696748000359 phosphorylation site [posttranslational modification] 696748000360 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 696748000361 ATP binding site [chemical binding]; other site 696748000362 Mg2+ binding site [ion binding]; other site 696748000363 G-X-G motif; other site 696748000364 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 696748000365 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 696748000366 ATP binding site [chemical binding]; other site 696748000367 Mg2+ binding site [ion binding]; other site 696748000368 G-X-G motif; other site 696748000369 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 696748000370 anchoring element; other site 696748000371 dimer interface [polypeptide binding]; other site 696748000372 ATP binding site [chemical binding]; other site 696748000373 TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030 696748000374 active site 696748000375 putative metal-binding site [ion binding]; other site 696748000376 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 696748000377 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 696748000378 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 696748000379 transmembrane helices; other site 696748000380 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 696748000381 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 696748000382 transmembrane helices; other site 696748000383 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 696748000384 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 696748000385 transmembrane helices; other site 696748000386 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 696748000387 Phosphoglycerate kinase; Region: PGK; pfam00162 696748000388 substrate binding site [chemical binding]; other site 696748000389 hinge regions; other site 696748000390 ADP binding site [chemical binding]; other site 696748000391 catalytic site [active] 696748000392 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 696748000393 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 696748000394 active site 696748000395 intersubunit interface [polypeptide binding]; other site 696748000396 zinc binding site [ion binding]; other site 696748000397 Na+ binding site [ion binding]; other site 696748000398 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SapF; COG4167 696748000399 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 696748000400 Walker A/P-loop; other site 696748000401 ATP binding site [chemical binding]; other site 696748000402 Q-loop/lid; other site 696748000403 ABC transporter signature motif; other site 696748000404 Walker B; other site 696748000405 D-loop; other site 696748000406 H-loop/switch region; other site 696748000407 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 696748000408 Predicted membrane protein [Function unknown]; Region: COG4541 696748000409 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 696748000410 dimer interface [polypeptide binding]; other site 696748000411 FMN binding site [chemical binding]; other site 696748000412 hypothetical protein; Provisional; Region: PRK05208 696748000413 glutathione reductase; Validated; Region: PRK06116 696748000414 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 696748000415 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 696748000416 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 696748000417 Transposase IS200 like; Region: Y1_Tnp; pfam01797 696748000418 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 696748000419 active site 696748000420 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 696748000421 Carbon starvation protein CstA; Region: CstA; pfam02554 696748000422 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 696748000423 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 696748000424 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 696748000425 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 696748000426 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 696748000427 dimer interface [polypeptide binding]; other site 696748000428 conserved gate region; other site 696748000429 putative PBP binding loops; other site 696748000430 ABC-ATPase subunit interface; other site 696748000431 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 696748000432 dimer interface [polypeptide binding]; other site 696748000433 conserved gate region; other site 696748000434 putative PBP binding loops; other site 696748000435 ABC-ATPase subunit interface; other site 696748000436 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 696748000437 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 696748000438 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 696748000439 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 696748000440 Walker A/P-loop; other site 696748000441 ATP binding site [chemical binding]; other site 696748000442 Q-loop/lid; other site 696748000443 ABC transporter signature motif; other site 696748000444 Walker B; other site 696748000445 D-loop; other site 696748000446 H-loop/switch region; other site 696748000447 TOBE domain; Region: TOBE_2; pfam08402 696748000448 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 696748000449 trimer interface; other site 696748000450 sugar binding site [chemical binding]; other site 696748000451 maltose regulon periplasmic protein; Provisional; Region: PRK10564 696748000452 transcriptional regulator MalT; Provisional; Region: PRK04841 696748000453 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 696748000454 DNA binding residues [nucleotide binding] 696748000455 dimerization interface [polypeptide binding]; other site 696748000456 maltodextrin phosphorylase; Provisional; Region: PRK14985 696748000457 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 696748000458 active site pocket [active] 696748000459 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 696748000460 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 696748000461 phosphoserine phosphatase SerB; Region: serB; TIGR00338 696748000462 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 696748000463 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 696748000464 motif II; other site 696748000465 Uncharacterized membrane protein affecting hemolysin expression [General function prediction only]; Region: AhpA; COG3726 696748000466 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 696748000467 rRNA binding site [nucleotide binding]; other site 696748000468 predicted 30S ribosome binding site; other site 696748000469 Predicted flavoproteins [General function prediction only]; Region: COG2081 696748000470 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 696748000471 Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553 696748000472 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 696748000473 Protein of unknown function (DUF3464); Region: DUF3464; pfam11947 696748000474 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK06901 696748000475 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 696748000476 putative deacylase active site [active] 696748000477 LexA regulated protein; Provisional; Region: PRK11675 696748000478 flavodoxin FldA; Validated; Region: PRK09267 696748000479 ferric uptake regulator; Provisional; Region: fur; PRK09462 696748000480 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 696748000481 metal binding site 2 [ion binding]; metal-binding site 696748000482 putative DNA binding helix; other site 696748000483 metal binding site 1 [ion binding]; metal-binding site 696748000484 dimer interface [polypeptide binding]; other site 696748000485 structural Zn2+ binding site [ion binding]; other site 696748000486 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 696748000487 mce related protein; Region: MCE; pfam02470 696748000488 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 696748000489 mce related protein; Region: MCE; pfam02470 696748000490 mce related protein; Region: MCE; pfam02470 696748000491 mce related protein; Region: MCE; pfam02470 696748000492 S-ribosylhomocysteinase; Provisional; Region: PRK02260 696748000493 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 696748000494 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 696748000495 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 696748000496 Walker A/P-loop; other site 696748000497 ATP binding site [chemical binding]; other site 696748000498 Q-loop/lid; other site 696748000499 ABC transporter signature motif; other site 696748000500 Walker B; other site 696748000501 D-loop; other site 696748000502 H-loop/switch region; other site 696748000503 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 696748000504 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 696748000505 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 696748000506 motif II; other site 696748000507 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 696748000508 hypothetical protein; Provisional; Region: PRK10396 696748000509 Uncharacterized protein family (UPF0149); Region: UPF0149; pfam03695 696748000510 SEC-C motif; Region: SEC-C; pfam02810 696748000511 putative oxidoreductase; Provisional; Region: PRK11579 696748000512 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 696748000513 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 696748000514 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 696748000515 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 696748000516 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 696748000517 Transcriptional regulator [Transcription]; Region: LysR; COG0583 696748000518 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 696748000519 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 696748000520 dimerization interface [polypeptide binding]; other site 696748000521 YCII-related domain; Region: YCII; cl00999 696748000522 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 696748000523 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 696748000524 Uncharacterized conserved protein [Function unknown]; Region: COG1359 696748000525 argininosuccinate lyase; Provisional; Region: PRK04833 696748000526 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 696748000527 active sites [active] 696748000528 tetramer interface [polypeptide binding]; other site 696748000529 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 696748000530 Sulfate transporter family; Region: Sulfate_transp; pfam00916 696748000531 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 696748000532 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 696748000533 non-specific DNA binding site [nucleotide binding]; other site 696748000534 salt bridge; other site 696748000535 sequence-specific DNA binding site [nucleotide binding]; other site 696748000536 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 696748000537 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 696748000538 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 696748000539 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 696748000540 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 696748000541 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 696748000542 dimer interface [polypeptide binding]; other site 696748000543 motif 1; other site 696748000544 active site 696748000545 motif 2; other site 696748000546 motif 3; other site 696748000547 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 696748000548 anticodon binding site; other site 696748000549 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 696748000550 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 696748000551 Nicotinamide mononucleotide transporter [Coenzyme metabolism]; Region: PnuC; COG3201 696748000552 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 696748000553 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 696748000554 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 696748000555 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 696748000556 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 696748000557 primosomal replication protein N; Provisional; Region: PRK02801 696748000558 generic binding surface I; other site 696748000559 generic binding surface II; other site 696748000560 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 696748000561 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 696748000562 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 696748000563 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 696748000564 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2841 696748000565 trehalose repressor; Provisional; Region: treR; PRK09492 696748000566 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 696748000567 DNA binding site [nucleotide binding] 696748000568 domain linker motif; other site 696748000569 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 696748000570 Methyltransferase domain; Region: Methyltransf_31; pfam13847 696748000571 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 696748000572 S-adenosylmethionine binding site [chemical binding]; other site 696748000573 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 696748000574 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 696748000575 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 696748000576 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 696748000577 Glutamine amidotransferase class-I; Region: GATase; pfam00117 696748000578 glutamine binding [chemical binding]; other site 696748000579 catalytic triad [active] 696748000580 anthranilate synthase component I; Provisional; Region: PRK13564 696748000581 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 696748000582 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 696748000583 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 696748000584 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 696748000585 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 696748000586 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 696748000587 RNA binding surface [nucleotide binding]; other site 696748000588 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 696748000589 probable active site [active] 696748000590 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 696748000591 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 696748000592 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 696748000593 putative dimerization interface [polypeptide binding]; other site 696748000594 Transferrin binding protein-like solute binding protein; Region: Lipoprotein_5; pfam01298 696748000595 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 696748000596 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 696748000597 THF binding site; other site 696748000598 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 696748000599 substrate binding site [chemical binding]; other site 696748000600 THF binding site; other site 696748000601 zinc-binding site [ion binding]; other site 696748000602 Protein of unknown function (DUF560); Region: DUF560; pfam04575 696748000603 Transferrin binding protein-like solute binding protein; Region: Lipoprotein_5; pfam01298 696748000604 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 696748000605 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 696748000606 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 696748000607 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 696748000608 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 696748000609 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 696748000610 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 696748000611 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 696748000612 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 696748000613 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 696748000614 active site 696748000615 putative DNA-binding cleft [nucleotide binding]; other site 696748000616 dimer interface [polypeptide binding]; other site 696748000617 hypothetical protein; Validated; Region: PRK00110 696748000618 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 696748000619 nudix motif; other site 696748000620 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 696748000621 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 696748000622 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 696748000623 dimer interface [polypeptide binding]; other site 696748000624 anticodon binding site; other site 696748000625 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 696748000626 homodimer interface [polypeptide binding]; other site 696748000627 motif 1; other site 696748000628 active site 696748000629 motif 2; other site 696748000630 GAD domain; Region: GAD; pfam02938 696748000631 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 696748000632 active site 696748000633 motif 3; other site 696748000634 hypothetical protein; Validated; Region: PRK06886 696748000635 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 696748000636 active site 696748000637 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 696748000638 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 696748000639 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 696748000640 poly(A) polymerase; Region: pcnB; TIGR01942 696748000641 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 696748000642 active site 696748000643 NTP binding site [chemical binding]; other site 696748000644 metal binding triad [ion binding]; metal-binding site 696748000645 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 696748000646 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 696748000647 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 696748000648 catalytic center binding site [active] 696748000649 ATP binding site [chemical binding]; other site 696748000650 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 696748000651 Dicarboxylate transport; Region: DctA-YdbH; cl14674 696748000652 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 696748000653 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 696748000654 dimer interface [polypeptide binding]; other site 696748000655 active site 696748000656 metal binding site [ion binding]; metal-binding site 696748000657 glutathione binding site [chemical binding]; other site 696748000658 ribonuclease T; Provisional; Region: PRK05168 696748000659 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 696748000660 active site 696748000661 catalytic site [active] 696748000662 substrate binding site [chemical binding]; other site 696748000663 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 696748000664 metabolite-proton symporter; Region: 2A0106; TIGR00883 696748000665 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696748000666 putative substrate translocation pore; other site 696748000667 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 696748000668 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 696748000669 dimer interface [polypeptide binding]; other site 696748000670 active site 696748000671 adenylate cyclase; Provisional; Region: cyaA; PRK09450 696748000672 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 696748000673 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 696748000674 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 696748000675 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 696748000676 TrkA-N domain; Region: TrkA_N; pfam02254 696748000677 cytochrome c nitrate reductase biogenesis protein NrfE; Region: cyt_nit_nrfE; TIGR03145 696748000678 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 696748000679 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 696748000680 cytochrome c nitrite reductase, accessory protein NrfF; Region: cyt_nit_nrfF; TIGR03147 696748000681 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 696748000682 binding surface 696748000683 TPR motif; other site 696748000684 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3787; cl17897 696748000685 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748 696748000686 heme utilization protein HutZ; Region: heme_HutZ; TIGR04110 696748000687 TonB-dependent lactoferrin and transferrin receptors; Region: TonB-tbp-lbp; TIGR01776 696748000688 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 696748000689 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 696748000690 ligand-binding site [chemical binding]; other site 696748000691 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 696748000692 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 696748000693 Prephenate dehydratase; Region: PDT; pfam00800 696748000694 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 696748000695 putative L-Phe binding site [chemical binding]; other site 696748000696 oligopeptidase A; Provisional; Region: PRK10911 696748000697 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 696748000698 active site 696748000699 Zn binding site [ion binding]; other site 696748000700 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 696748000701 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 696748000702 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 696748000703 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 696748000704 FeS/SAM binding site; other site 696748000705 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 696748000706 Pyruvate formate lyase 1; Region: PFL1; cd01678 696748000707 coenzyme A binding site [chemical binding]; other site 696748000708 active site 696748000709 catalytic residues [active] 696748000710 glycine loop; other site 696748000711 formate transporter FocA; Region: formate_focA; TIGR04060 696748000712 Predicted membrane protein [Function unknown]; Region: COG1238 696748000713 heat shock protein HtpX; Provisional; Region: PRK05457 696748000714 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 696748000715 active site 696748000716 DNA polymerase IV; Validated; Region: PRK02406 696748000717 DNA binding site [nucleotide binding] 696748000718 Predicted membrane protein [Function unknown]; Region: COG2431 696748000719 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 696748000720 chorismate binding enzyme; Region: Chorismate_bind; cl10555 696748000721 aminotransferase AlaT; Validated; Region: PRK09265 696748000722 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 696748000723 pyridoxal 5'-phosphate binding site [chemical binding]; other site 696748000724 homodimer interface [polypeptide binding]; other site 696748000725 catalytic residue [active] 696748000726 Predicted permeases [General function prediction only]; Region: RarD; COG2962 696748000727 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 696748000728 Predicted permeases [General function prediction only]; Region: RarD; COG2962 696748000729 primosome assembly protein PriA; Validated; Region: PRK05580 696748000730 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 696748000731 ATP binding site [chemical binding]; other site 696748000732 putative Mg++ binding site [ion binding]; other site 696748000733 helicase superfamily c-terminal domain; Region: HELICc; smart00490 696748000734 ATP-binding site [chemical binding]; other site 696748000735 Uncharacterized conserved protein [Function unknown]; Region: COG1434 696748000736 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 696748000737 putative active site [active] 696748000738 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 696748000739 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 696748000740 putative trimer interface [polypeptide binding]; other site 696748000741 putative CoA binding site [chemical binding]; other site 696748000742 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 696748000743 NeuB family; Region: NeuB; pfam03102 696748000744 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 696748000745 NeuB binding interface [polypeptide binding]; other site 696748000746 putative substrate binding site [chemical binding]; other site 696748000747 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 696748000748 ligand binding site; other site 696748000749 tetramer interface; other site 696748000750 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 696748000751 active site 696748000752 catalytic triad [active] 696748000753 oxyanion hole [active] 696748000754 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 696748000755 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 696748000756 active site 696748000757 homodimer interface [polypeptide binding]; other site 696748000758 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 696748000759 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 696748000760 Glycosyltransferase family 52; Region: Glyco_transf_52; pfam07922 696748000761 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 696748000762 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 696748000763 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 696748000764 active site 696748000765 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 696748000766 GT2_AmsE_like is involved in exopolysaccharide amylovora biosynthesis; Region: GT2_AmsE_like; cd04195 696748000767 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 696748000768 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 696748000769 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 696748000770 Nucleoside recognition; Region: Gate; pfam07670 696748000771 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 696748000772 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 696748000773 intersubunit interface [polypeptide binding]; other site 696748000774 active site 696748000775 catalytic residue [active] 696748000776 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 696748000777 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 696748000778 N-acetyl-gamma-glutamyl-phosphate reductase; Provisional; Region: PRK11863 696748000779 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 696748000780 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 696748000781 homohexameric interface [polypeptide binding]; other site 696748000782 feedback inhibition sensing region; other site 696748000783 nucleotide binding site [chemical binding]; other site 696748000784 N-acetyl-L-glutamate binding site [chemical binding]; other site 696748000785 acetylornithine aminotransferase; Provisional; Region: PRK02627 696748000786 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 696748000787 inhibitor-cofactor binding pocket; inhibition site 696748000788 pyridoxal 5'-phosphate binding site [chemical binding]; other site 696748000789 catalytic residue [active] 696748000790 Transferrin binding protein-like solute binding protein; Region: Lipoprotein_5; pfam01298 696748000791 TonB-dependent lactoferrin and transferrin receptors; Region: TonB-tbp-lbp; TIGR01776 696748000792 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 696748000793 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 696748000794 transcription termination factor Rho; Provisional; Region: rho; PRK09376 696748000795 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 696748000796 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 696748000797 RNA binding site [nucleotide binding]; other site 696748000798 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 696748000799 multimer interface [polypeptide binding]; other site 696748000800 Walker A motif; other site 696748000801 ATP binding site [chemical binding]; other site 696748000802 Walker B motif; other site 696748000803 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 696748000804 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 696748000805 dimer interface [polypeptide binding]; other site 696748000806 pyridoxal 5'-phosphate binding site [chemical binding]; other site 696748000807 catalytic residue [active] 696748000808 homoserine kinase; Provisional; Region: PRK01212 696748000809 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 696748000810 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 696748000811 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 696748000812 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 696748000813 nucleotide binding site [chemical binding]; other site 696748000814 substrate binding site [chemical binding]; other site 696748000815 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 696748000816 dimer interface [polypeptide binding]; other site 696748000817 putative threonine allosteric regulatory site; other site 696748000818 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 696748000819 putative threonine allosteric regulatory site; other site 696748000820 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 696748000821 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 696748000822 superoxide dismutase; Provisional; Region: PRK10925 696748000823 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 696748000824 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 696748000825 alanine racemase; Reviewed; Region: alr; PRK00053 696748000826 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 696748000827 active site 696748000828 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 696748000829 substrate binding site [chemical binding]; other site 696748000830 catalytic residues [active] 696748000831 dimer interface [polypeptide binding]; other site 696748000832 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 696748000833 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 696748000834 Helicase; Region: Helicase_RecD; pfam05127 696748000835 Family description; Region: UvrD_C_2; pfam13538 696748000836 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 696748000837 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 696748000838 metal binding site [ion binding]; metal-binding site 696748000839 dimer interface [polypeptide binding]; other site 696748000840 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 696748000841 active site 696748000842 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 696748000843 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 696748000844 catalytic site [active] 696748000845 G-X2-G-X-G-K; other site 696748000846 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 696748000847 hypothetical protein; Validated; Region: PRK01777 696748000848 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 696748000849 putative coenzyme Q binding site [chemical binding]; other site 696748000850 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 696748000851 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 696748000852 Walker A/P-loop; other site 696748000853 ATP binding site [chemical binding]; other site 696748000854 Q-loop/lid; other site 696748000855 ABC transporter signature motif; other site 696748000856 Walker B; other site 696748000857 D-loop; other site 696748000858 H-loop/switch region; other site 696748000859 TOBE domain; Region: TOBE; cl01440 696748000860 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 696748000861 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 696748000862 dimer interface [polypeptide binding]; other site 696748000863 conserved gate region; other site 696748000864 putative PBP binding loops; other site 696748000865 ABC-ATPase subunit interface; other site 696748000866 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 696748000867 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 696748000868 inner membrane transport permease; Provisional; Region: PRK15066 696748000869 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 696748000870 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 696748000871 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 696748000872 Walker A/P-loop; other site 696748000873 ATP binding site [chemical binding]; other site 696748000874 Q-loop/lid; other site 696748000875 ABC transporter signature motif; other site 696748000876 Walker B; other site 696748000877 D-loop; other site 696748000878 H-loop/switch region; other site 696748000879 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 696748000880 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 696748000881 Walker A motif; other site 696748000882 ATP binding site [chemical binding]; other site 696748000883 Walker B motif; other site 696748000884 DNA polymerase III subunit delta'; Validated; Region: PRK08485 696748000885 arginine finger; other site 696748000886 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 696748000887 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 696748000888 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 696748000889 active site 696748000890 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 696748000891 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 696748000892 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 696748000893 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 696748000894 metal binding site [ion binding]; metal-binding site 696748000895 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 696748000896 sulfur relay protein, TusE/DsrC/DsvC family; Region: dsrC_tusE_dsvC; TIGR03342 696748000897 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 696748000898 YccA-like proteins; Region: YccA_like; cd10433 696748000899 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 696748000900 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 696748000901 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 696748000902 N-terminal plug; other site 696748000903 ligand-binding site [chemical binding]; other site 696748000904 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 696748000905 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 696748000906 GIY-YIG motif/motif A; other site 696748000907 active site 696748000908 catalytic site [active] 696748000909 putative DNA binding site [nucleotide binding]; other site 696748000910 metal binding site [ion binding]; metal-binding site 696748000911 UvrB/uvrC motif; Region: UVR; pfam02151 696748000912 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 696748000913 Helix-hairpin-helix motif; Region: HHH; pfam00633 696748000914 xanthine permease; Region: pbuX; TIGR03173 696748000915 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 696748000916 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 696748000917 catalytic residues [active] 696748000918 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 696748000919 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 696748000920 HflK protein; Region: hflK; TIGR01933 696748000921 FtsH protease regulator HflC; Provisional; Region: PRK11029 696748000922 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 696748000923 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 696748000924 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 696748000925 GDP-binding site [chemical binding]; other site 696748000926 ACT binding site; other site 696748000927 IMP binding site; other site 696748000928 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 696748000929 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 696748000930 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 696748000931 Ligand Binding Site [chemical binding]; other site 696748000932 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 696748000933 active site residue [active] 696748000934 Uncharacterized conserved protein [Function unknown]; Region: COG2128 696748000935 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 696748000936 Maf-like protein; Region: Maf; pfam02545 696748000937 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 696748000938 active site 696748000939 dimer interface [polypeptide binding]; other site 696748000940 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 696748000941 Sulfate transporter family; Region: Sulfate_transp; pfam00916 696748000942 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 696748000943 Ferritin-like domain; Region: Ferritin; pfam00210 696748000944 ferroxidase diiron center [ion binding]; other site 696748000945 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 696748000946 Ferritin-like domain; Region: Ferritin; pfam00210 696748000947 ferroxidase diiron center [ion binding]; other site 696748000948 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 696748000949 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 696748000950 Protein export membrane protein; Region: SecD_SecF; pfam02355 696748000951 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 696748000952 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 696748000953 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 696748000954 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 696748000955 Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; pfam09695 696748000956 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 696748000957 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 696748000958 S-adenosylmethionine binding site [chemical binding]; other site 696748000959 DNA gyrase subunit A; Validated; Region: PRK05560 696748000960 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 696748000961 CAP-like domain; other site 696748000962 active site 696748000963 primary dimer interface [polypeptide binding]; other site 696748000964 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 696748000965 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 696748000966 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 696748000967 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 696748000968 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 696748000969 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 696748000970 BRO family, N-terminal domain; Region: Bro-N; smart01040 696748000971 ABC transporter ATPase component; Reviewed; Region: PRK11147 696748000972 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 696748000973 Walker A/P-loop; other site 696748000974 ATP binding site [chemical binding]; other site 696748000975 ABC transporter signature motif; other site 696748000976 Walker B; other site 696748000977 D-loop; other site 696748000978 H-loop/switch region; other site 696748000979 ABC transporter; Region: ABC_tran_2; pfam12848 696748000980 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 696748000981 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 696748000982 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 696748000983 putative ATP binding site [chemical binding]; other site 696748000984 putative substrate interface [chemical binding]; other site 696748000985 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 696748000986 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 696748000987 putative catalytic cysteine [active] 696748000988 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 696748000989 putative active site [active] 696748000990 metal binding site [ion binding]; metal-binding site 696748000991 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 696748000992 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 696748000993 domain interfaces; other site 696748000994 active site 696748000995 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 696748000996 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 696748000997 active site 696748000998 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 696748000999 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 696748001000 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 696748001001 HemY protein N-terminus; Region: HemY_N; pfam07219 696748001002 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 696748001003 TPR motif; other site 696748001004 binding surface 696748001005 Protein of unknown function (DUF808); Region: DUF808; pfam05661 696748001006 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 696748001007 16S/18S rRNA binding site [nucleotide binding]; other site 696748001008 S13e-L30e interaction site [polypeptide binding]; other site 696748001009 25S rRNA binding site [nucleotide binding]; other site 696748001010 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 696748001011 periplasmic folding chaperone; Provisional; Region: PRK10788 696748001012 SurA N-terminal domain; Region: SurA_N_3; cl07813 696748001013 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 696748001014 hypothetical protein; Provisional; Region: PRK11111 696748001015 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 696748001016 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 696748001017 peptide binding site [polypeptide binding]; other site 696748001018 antiporter inner membrane protein; Provisional; Region: PRK11670 696748001019 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 696748001020 Walker A motif; other site 696748001021 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 696748001022 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 696748001023 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 696748001024 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 696748001025 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 696748001026 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 696748001027 active site 696748001028 catalytic residues [active] 696748001029 galactokinase; Provisional; Region: PRK05101 696748001030 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 696748001031 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 696748001032 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 696748001033 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 696748001034 dimer interface [polypeptide binding]; other site 696748001035 active site 696748001036 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 696748001037 sensor protein QseC; Provisional; Region: PRK10337 696748001038 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 696748001039 dimer interface [polypeptide binding]; other site 696748001040 phosphorylation site [posttranslational modification] 696748001041 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 696748001042 ATP binding site [chemical binding]; other site 696748001043 Mg2+ binding site [ion binding]; other site 696748001044 G-X-G motif; other site 696748001045 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 696748001046 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 696748001047 active site 696748001048 phosphorylation site [posttranslational modification] 696748001049 intermolecular recognition site; other site 696748001050 dimerization interface [polypeptide binding]; other site 696748001051 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 696748001052 DNA binding site [nucleotide binding] 696748001053 Bacterial OB fold (BOF) protein; Region: BOF; cl01196 696748001054 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 696748001055 Bacterial OB fold (BOF) protein; Region: BOF; cl01196 696748001056 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 696748001057 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 696748001058 dimer interface [polypeptide binding]; other site 696748001059 active site 696748001060 glycine-pyridoxal phosphate binding site [chemical binding]; other site 696748001061 folate binding site [chemical binding]; other site 696748001062 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 696748001063 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 696748001064 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 696748001065 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 696748001066 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 696748001067 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 696748001068 active site 696748001069 dimer interface [polypeptide binding]; other site 696748001070 motif 1; other site 696748001071 motif 2; other site 696748001072 motif 3; other site 696748001073 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 696748001074 anticodon binding site; other site 696748001075 translation initiation factor IF-3; Region: infC; TIGR00168 696748001076 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 696748001077 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 696748001078 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 696748001079 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 696748001080 23S rRNA binding site [nucleotide binding]; other site 696748001081 L21 binding site [polypeptide binding]; other site 696748001082 L13 binding site [polypeptide binding]; other site 696748001083 AAA domain; Region: AAA_17; pfam13207 696748001084 putative metal dependent hydrolase; Provisional; Region: PRK11598 696748001085 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 696748001086 Domain of unknown function DUF21; Region: DUF21; pfam01595 696748001087 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 696748001088 Transporter associated domain; Region: CorC_HlyC; smart01091 696748001089 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 696748001090 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 696748001091 active site 696748001092 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 696748001093 catalytic core [active] 696748001094 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 696748001095 hypothetical protein; Validated; Region: PRK00228 696748001096 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 696748001097 RNA methyltransferase, RsmE family; Region: TIGR00046 696748001098 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cd02106 696748001099 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 696748001100 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 696748001101 dimer interface [polypeptide binding]; other site 696748001102 putative radical transfer pathway; other site 696748001103 diiron center [ion binding]; other site 696748001104 tyrosyl radical; other site 696748001105 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 696748001106 ATP cone domain; Region: ATP-cone; pfam03477 696748001107 Class I ribonucleotide reductase; Region: RNR_I; cd01679 696748001108 active site 696748001109 dimer interface [polypeptide binding]; other site 696748001110 catalytic residues [active] 696748001111 effector binding site; other site 696748001112 R2 peptide binding site; other site 696748001113 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 696748001114 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 696748001115 putative active site [active] 696748001116 putative metal binding site [ion binding]; other site 696748001117 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 696748001118 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 696748001119 tetramer interface [polypeptide binding]; other site 696748001120 heme binding pocket [chemical binding]; other site 696748001121 NADPH binding site [chemical binding]; other site 696748001122 heat shock protein 90; Provisional; Region: PRK05218 696748001123 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 696748001124 ATP binding site [chemical binding]; other site 696748001125 Mg2+ binding site [ion binding]; other site 696748001126 G-X-G motif; other site 696748001127 cystathionine beta-lyase; Provisional; Region: PRK08114 696748001128 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 696748001129 homodimer interface [polypeptide binding]; other site 696748001130 substrate-cofactor binding pocket; other site 696748001131 pyridoxal 5'-phosphate binding site [chemical binding]; other site 696748001132 catalytic residue [active] 696748001133 disulfide bond formation protein B; Provisional; Region: PRK01749 696748001134 sodium/proton antiporter; Reviewed; Region: nhaB; PRK09547 696748001135 fatty acid metabolism regulator; Provisional; Region: PRK04984 696748001136 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 696748001137 DNA-binding site [nucleotide binding]; DNA binding site 696748001138 FadR C-terminal domain; Region: FadR_C; pfam07840 696748001139 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 696748001140 PhoH-like protein; Region: PhoH; pfam02562 696748001141 transketolase; Reviewed; Region: PRK12753 696748001142 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 696748001143 TPP-binding site [chemical binding]; other site 696748001144 dimer interface [polypeptide binding]; other site 696748001145 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 696748001146 PYR/PP interface [polypeptide binding]; other site 696748001147 dimer interface [polypeptide binding]; other site 696748001148 TPP binding site [chemical binding]; other site 696748001149 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 696748001150 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 696748001151 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 696748001152 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 696748001153 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 696748001154 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 696748001155 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 696748001156 putative active site [active] 696748001157 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 696748001158 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 696748001159 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 696748001160 putative dimerization interface [polypeptide binding]; other site 696748001161 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 696748001162 putative catalytic site [active] 696748001163 putative phosphate binding site [ion binding]; other site 696748001164 active site 696748001165 metal binding site A [ion binding]; metal-binding site 696748001166 DNA binding site [nucleotide binding] 696748001167 putative AP binding site [nucleotide binding]; other site 696748001168 putative metal binding site B [ion binding]; other site 696748001169 Predicted permease [General function prediction only]; Region: COG2056 696748001170 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 696748001171 Predicted membrane protein [Function unknown]; Region: COG1288; cl17886 696748001172 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 696748001173 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 696748001174 Ligand Binding Site [chemical binding]; other site 696748001175 Protein of unknown function, DUF412; Region: DUF412; pfam04217 696748001176 intracellular septation protein A; Reviewed; Region: PRK00259 696748001177 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 696748001178 YciI-like protein; Reviewed; Region: PRK11370 696748001179 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 696748001180 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 696748001181 metal binding triad; other site 696748001182 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 696748001183 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 696748001184 metal binding triad; other site 696748001185 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 696748001186 Uncharacterized protein family (UPF0231); Region: UPF0231; pfam06062 696748001187 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 696748001188 putative transporter; Validated; Region: PRK03818 696748001189 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 696748001190 TrkA-C domain; Region: TrkA_C; pfam02080 696748001191 TrkA-C domain; Region: TrkA_C; pfam02080 696748001192 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 696748001193 Der GTPase activator; Provisional; Region: PRK05244 696748001194 Protein of unknown function (DUF2489); Region: DUF2489; pfam10675 696748001195 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 696748001196 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 696748001197 FeS/SAM binding site; other site 696748001198 HemN C-terminal domain; Region: HemN_C; pfam06969 696748001199 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 696748001200 OstA-like protein; Region: OstA; pfam03968 696748001201 Organic solvent tolerance protein; Region: OstA_C; pfam04453 696748001202 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 696748001203 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 696748001204 purine monophosphate binding site [chemical binding]; other site 696748001205 dimer interface [polypeptide binding]; other site 696748001206 putative catalytic residues [active] 696748001207 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 696748001208 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 696748001209 metal-binding heat shock protein; Provisional; Region: PRK00016 696748001210 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 696748001211 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 696748001212 Coenzyme A binding pocket [chemical binding]; other site 696748001213 RTX toxin acyltransferase family; Region: HlyC; pfam02794 696748001214 RTX N-terminal domain; Region: RTX; pfam02382 696748001215 RTX C-terminal domain; Region: RTX_C; pfam08339 696748001216 Winged helix-turn helix; Region: HTH_29; pfam13551 696748001217 Helix-turn-helix domain; Region: HTH_28; pfam13518 696748001218 Integrase core domain; Region: rve; pfam00665 696748001219 Integrase core domain; Region: rve_3; pfam13683 696748001220 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 696748001221 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 696748001222 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 696748001223 Predicted acetyltransferase [General function prediction only]; Region: COG2388 696748001224 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 696748001225 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 696748001226 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 696748001227 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 696748001228 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 696748001229 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK11805 696748001230 HemK family putative methylases; Region: hemK_fam; TIGR00536 696748001231 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06173 696748001232 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 696748001233 inhibitor-cofactor binding pocket; inhibition site 696748001234 pyridoxal 5'-phosphate binding site [chemical binding]; other site 696748001235 catalytic residue [active] 696748001236 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 696748001237 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 696748001238 substrate-cofactor binding pocket; other site 696748001239 pyridoxal 5'-phosphate binding site [chemical binding]; other site 696748001240 catalytic residue [active] 696748001241 Protein of unknown function (DUF452); Region: DUF452; cl01062 696748001242 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 696748001243 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 696748001244 S-adenosylmethionine binding site [chemical binding]; other site 696748001245 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 696748001246 AAA domain; Region: AAA_26; pfam13500 696748001247 hypothetical protein; Provisional; Region: PRK04946 696748001248 Smr domain; Region: Smr; pfam01713 696748001249 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 696748001250 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 696748001251 dimer interface [polypeptide binding]; other site 696748001252 phosphorylation site [posttranslational modification] 696748001253 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 696748001254 ATP binding site [chemical binding]; other site 696748001255 Mg2+ binding site [ion binding]; other site 696748001256 G-X-G motif; other site 696748001257 Response regulator receiver domain; Region: Response_reg; pfam00072 696748001258 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 696748001259 active site 696748001260 phosphorylation site [posttranslational modification] 696748001261 intermolecular recognition site; other site 696748001262 dimerization interface [polypeptide binding]; other site 696748001263 FOG: HPt domain [Signal transduction mechanisms]; Region: ArcB; COG2198 696748001264 putative binding surface; other site 696748001265 active site 696748001266 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 696748001267 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 696748001268 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 696748001269 DNA binding site [nucleotide binding] 696748001270 active site 696748001271 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 696748001272 iron-sulfur cluster assembly transcription factor IscR; Region: IscR; TIGR02010 696748001273 Rrf2 family protein; Region: rrf2_super; TIGR00738 696748001274 cysteine desulfurase; Provisional; Region: PRK14012 696748001275 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 696748001276 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 696748001277 catalytic residue [active] 696748001278 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 696748001279 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 696748001280 trimerization site [polypeptide binding]; other site 696748001281 active site 696748001282 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 696748001283 co-chaperone HscB; Provisional; Region: hscB; PRK01773 696748001284 DnaJ domain; Region: DnaJ; pfam00226 696748001285 HSP70 interaction site [polypeptide binding]; other site 696748001286 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 696748001287 Protein of unknown function, DUF606; Region: DUF606; pfam04657 696748001288 Protein of unknown function DUF2625; Region: DUF2625; pfam10946 696748001289 chaperone protein HscA; Provisional; Region: hscA; PRK05183 696748001290 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 696748001291 nucleotide binding site [chemical binding]; other site 696748001292 putative NEF/HSP70 interaction site [polypeptide binding]; other site 696748001293 SBD interface [polypeptide binding]; other site 696748001294 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 696748001295 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 696748001296 catalytic loop [active] 696748001297 iron binding site [ion binding]; other site 696748001298 Iron-sulphur cluster assembly; Region: Fe-S_assembly; cl01123 696748001299 Tetratricopeptide repeat; Region: TPR_16; pfam13432 696748001300 Protein of unknown function (DUF560); Region: DUF560; pfam04575 696748001301 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 696748001302 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 696748001303 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 696748001304 putative transposase OrfB; Reviewed; Region: PHA02517 696748001305 HTH-like domain; Region: HTH_21; pfam13276 696748001306 Integrase core domain; Region: rve; pfam00665 696748001307 Integrase core domain; Region: rve_2; pfam13333 696748001308 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 696748001309 Helix-turn-helix domain; Region: HTH_28; pfam13518 696748001310 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 696748001311 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 696748001312 active site 696748001313 NTP binding site [chemical binding]; other site 696748001314 metal binding triad [ion binding]; metal-binding site 696748001315 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 696748001316 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 696748001317 Zn2+ binding site [ion binding]; other site 696748001318 Mg2+ binding site [ion binding]; other site 696748001319 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 696748001320 substrate binding site [chemical binding]; other site 696748001321 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 696748001322 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 696748001323 active site 696748001324 HIGH motif; other site 696748001325 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 696748001326 KMSKS motif; other site 696748001327 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 696748001328 tRNA binding surface [nucleotide binding]; other site 696748001329 anticodon binding site; other site 696748001330 L-arabinose isomerase; Provisional; Region: PRK02929 696748001331 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 696748001332 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 696748001333 trimer interface [polypeptide binding]; other site 696748001334 putative substrate binding site [chemical binding]; other site 696748001335 putative metal binding site [ion binding]; other site 696748001336 L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 696748001337 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 696748001338 putative N- and C-terminal domain interface [polypeptide binding]; other site 696748001339 putative active site [active] 696748001340 MgATP binding site [chemical binding]; other site 696748001341 catalytic site [active] 696748001342 metal binding site [ion binding]; metal-binding site 696748001343 putative carbohydrate binding site [chemical binding]; other site 696748001344 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 696748001345 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 696748001346 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 696748001347 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 696748001348 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 696748001349 TM-ABC transporter signature motif; other site 696748001350 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 696748001351 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 696748001352 Walker A/P-loop; other site 696748001353 ATP binding site [chemical binding]; other site 696748001354 Q-loop/lid; other site 696748001355 ABC transporter signature motif; other site 696748001356 Walker B; other site 696748001357 D-loop; other site 696748001358 H-loop/switch region; other site 696748001359 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 696748001360 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 696748001361 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 696748001362 ligand binding site [chemical binding]; other site 696748001363 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 696748001364 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 696748001365 Walker A/P-loop; other site 696748001366 ATP binding site [chemical binding]; other site 696748001367 Q-loop/lid; other site 696748001368 ABC transporter signature motif; other site 696748001369 Walker B; other site 696748001370 D-loop; other site 696748001371 H-loop/switch region; other site 696748001372 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 696748001373 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 696748001374 dimer interface [polypeptide binding]; other site 696748001375 conserved gate region; other site 696748001376 ABC-ATPase subunit interface; other site 696748001377 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 696748001378 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 696748001379 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 696748001380 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 696748001381 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 696748001382 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 696748001383 Transcriptional regulator [Transcription]; Region: LysR; COG0583 696748001384 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 696748001385 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 696748001386 putative effector binding pocket; other site 696748001387 putative dimerization interface [polypeptide binding]; other site 696748001388 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 696748001389 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 696748001390 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 696748001391 trimer interface [polypeptide binding]; other site 696748001392 active site 696748001393 substrate binding site [chemical binding]; other site 696748001394 CoA binding site [chemical binding]; other site 696748001395 Uncharacterized conserved protein [Function unknown]; Region: COG4925 696748001396 3-deoxy-D-manno-octulosonic-acid kinase; Reviewed; Region: PRK01723 696748001397 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 696748001398 active site 696748001399 ATP binding site [chemical binding]; other site 696748001400 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 696748001401 homodecamer interface [polypeptide binding]; other site 696748001402 GTP cyclohydrolase I; Provisional; Region: PLN03044 696748001403 active site 696748001404 putative catalytic site residues [active] 696748001405 zinc binding site [ion binding]; other site 696748001406 GTP-CH-I/GFRP interaction surface; other site 696748001407 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 696748001408 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 696748001409 dimerization interface 3.5A [polypeptide binding]; other site 696748001410 active site 696748001411 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 696748001412 30S subunit binding site; other site 696748001413 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 696748001414 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 696748001415 putative acyl-acceptor binding pocket; other site 696748001416 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 696748001417 dihydrodipicolinate synthase; Region: dapA; TIGR00674 696748001418 dimer interface [polypeptide binding]; other site 696748001419 active site 696748001420 catalytic residue [active] 696748001421 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 696748001422 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696748001423 putative substrate translocation pore; other site 696748001424 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 696748001425 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 696748001426 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 696748001427 homodimer interface [polypeptide binding]; other site 696748001428 NADP binding site [chemical binding]; other site 696748001429 substrate binding site [chemical binding]; other site 696748001430 Repair protein; Region: Repair_PSII; pfam04536 696748001431 Repair protein; Region: Repair_PSII; cl01535 696748001432 LemA family; Region: LemA; pfam04011 696748001433 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 696748001434 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 696748001435 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 696748001436 active site 696748001437 P-loop; other site 696748001438 phosphorylation site [posttranslational modification] 696748001439 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 696748001440 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 696748001441 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 696748001442 putative substrate binding site [chemical binding]; other site 696748001443 putative ATP binding site [chemical binding]; other site 696748001444 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK13779 696748001445 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 696748001446 active site 696748001447 phosphorylation site [posttranslational modification] 696748001448 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 696748001449 active site 696748001450 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 696748001451 dimerization domain swap beta strand [polypeptide binding]; other site 696748001452 regulatory protein interface [polypeptide binding]; other site 696748001453 active site 696748001454 regulatory phosphorylation site [posttranslational modification]; other site 696748001455 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 696748001456 dimerization domain swap beta strand [polypeptide binding]; other site 696748001457 regulatory protein interface [polypeptide binding]; other site 696748001458 active site 696748001459 regulatory phosphorylation site [posttranslational modification]; other site 696748001460 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 696748001461 dimerization domain swap beta strand [polypeptide binding]; other site 696748001462 regulatory protein interface [polypeptide binding]; other site 696748001463 active site 696748001464 regulatory phosphorylation site [posttranslational modification]; other site 696748001465 glycogen branching enzyme; Provisional; Region: PRK05402 696748001466 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 696748001467 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 696748001468 active site 696748001469 catalytic site [active] 696748001470 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 696748001471 glycogen debranching enzyme; Provisional; Region: PRK03705 696748001472 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 696748001473 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 696748001474 active site 696748001475 catalytic site [active] 696748001476 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 696748001477 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 696748001478 ligand binding site; other site 696748001479 oligomer interface; other site 696748001480 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 696748001481 dimer interface [polypeptide binding]; other site 696748001482 N-terminal domain interface [polypeptide binding]; other site 696748001483 sulfate 1 binding site; other site 696748001484 glycogen synthase; Provisional; Region: glgA; PRK00654 696748001485 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 696748001486 ADP-binding pocket [chemical binding]; other site 696748001487 homodimer interface [polypeptide binding]; other site 696748001488 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 696748001489 homodimer interface [polypeptide binding]; other site 696748001490 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 696748001491 active site pocket [active] 696748001492 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 696748001493 active site 696748001494 multimer interface [polypeptide binding]; other site 696748001495 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 696748001496 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 696748001497 active site 696748001498 HIGH motif; other site 696748001499 KMSKS motif; other site 696748001500 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 696748001501 tRNA binding surface [nucleotide binding]; other site 696748001502 anticodon binding site; other site 696748001503 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 696748001504 dimer interface [polypeptide binding]; other site 696748001505 putative tRNA-binding site [nucleotide binding]; other site 696748001506 O-succinylbenzoate synthase; Provisional; Region: PRK05105 696748001507 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 696748001508 active site 696748001509 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 696748001510 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 696748001511 RNA binding surface [nucleotide binding]; other site 696748001512 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 696748001513 active site 696748001514 uracil binding [chemical binding]; other site 696748001515 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696748001516 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 696748001517 putative substrate translocation pore; other site 696748001518 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 696748001519 endonuclease IV; Provisional; Region: PRK01060 696748001520 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 696748001521 AP (apurinic/apyrimidinic) site pocket; other site 696748001522 DNA interaction; other site 696748001523 Metal-binding active site; metal-binding site 696748001524 NlpC/P60 family; Region: NLPC_P60; pfam00877 696748001525 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 696748001526 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 696748001527 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 696748001528 ligand binding site [chemical binding]; other site 696748001529 active site 696748001530 UGI interface [polypeptide binding]; other site 696748001531 catalytic site [active] 696748001532 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 696748001533 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 696748001534 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 696748001535 ATP binding site [chemical binding]; other site 696748001536 putative Mg++ binding site [ion binding]; other site 696748001537 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 696748001538 nucleotide binding region [chemical binding]; other site 696748001539 ATP-binding site [chemical binding]; other site 696748001540 Helicase associated domain (HA2); Region: HA2; pfam04408 696748001541 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 696748001542 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 696748001543 Predicted membrane protein [Function unknown]; Region: COG2707 696748001544 GrpE; Region: GrpE; pfam01025 696748001545 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 696748001546 dimer interface [polypeptide binding]; other site 696748001547 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 696748001548 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 696748001549 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 696748001550 multidrug efflux protein; Reviewed; Region: PRK01766 696748001551 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 696748001552 cation binding site [ion binding]; other site 696748001553 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 696748001554 Part of AAA domain; Region: AAA_19; pfam13245 696748001555 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 696748001556 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 696748001557 non-specific DNA binding site [nucleotide binding]; other site 696748001558 salt bridge; other site 696748001559 sequence-specific DNA binding site [nucleotide binding]; other site 696748001560 HipA N-terminal domain; Region: couple_hipA; TIGR03071 696748001561 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 696748001562 HipA-like N-terminal domain; Region: HipA_N; pfam07805 696748001563 HipA-like C-terminal domain; Region: HipA_C; pfam07804 696748001564 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 696748001565 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 696748001566 Nucleoside recognition; Region: Gate; pfam07670 696748001567 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 696748001568 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 696748001569 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 696748001570 FeS/SAM binding site; other site 696748001571 glycine radical enzyme, YjjI family; Region: glycyl_YjjI; TIGR04040 696748001572 Pyruvate formate lyase; Region: PFL; pfam02901 696748001573 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 696748001574 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 696748001575 putative active site [active] 696748001576 catalytic triad [active] 696748001577 putative dimer interface [polypeptide binding]; other site 696748001578 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 696748001579 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 696748001580 Transporter associated domain; Region: CorC_HlyC; smart01091 696748001581 Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; cl11437 696748001582 hypothetical protein; Provisional; Region: PRK03641 696748001583 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 696748001584 amphipathic channel; other site 696748001585 Asn-Pro-Ala signature motifs; other site 696748001586 glycerol kinase; Provisional; Region: glpK; PRK00047 696748001587 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 696748001588 N- and C-terminal domain interface [polypeptide binding]; other site 696748001589 active site 696748001590 MgATP binding site [chemical binding]; other site 696748001591 catalytic site [active] 696748001592 metal binding site [ion binding]; metal-binding site 696748001593 glycerol binding site [chemical binding]; other site 696748001594 homotetramer interface [polypeptide binding]; other site 696748001595 homodimer interface [polypeptide binding]; other site 696748001596 FBP binding site [chemical binding]; other site 696748001597 protein IIAGlc interface [polypeptide binding]; other site 696748001598 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 696748001599 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 696748001600 active site 696748001601 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 696748001602 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 696748001603 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 696748001604 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 696748001605 trimer interface [polypeptide binding]; other site 696748001606 active site 696748001607 UDP-GlcNAc binding site [chemical binding]; other site 696748001608 lipid binding site [chemical binding]; lipid-binding site 696748001609 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 696748001610 periplasmic chaperone; Provisional; Region: PRK10780 696748001611 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 696748001612 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 696748001613 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 696748001614 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 696748001615 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 696748001616 Surface antigen; Region: Bac_surface_Ag; pfam01103 696748001617 zinc metallopeptidase RseP; Provisional; Region: PRK10779 696748001618 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 696748001619 active site 696748001620 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 696748001621 protein binding site [polypeptide binding]; other site 696748001622 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 696748001623 protein binding site [polypeptide binding]; other site 696748001624 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 696748001625 putative substrate binding region [chemical binding]; other site 696748001626 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 696748001627 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 696748001628 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 696748001629 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 696748001630 catalytic residue [active] 696748001631 putative FPP diphosphate binding site; other site 696748001632 putative FPP binding hydrophobic cleft; other site 696748001633 dimer interface [polypeptide binding]; other site 696748001634 putative IPP diphosphate binding site; other site 696748001635 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 696748001636 fructokinase; Reviewed; Region: PRK09557 696748001637 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 696748001638 nucleotide binding site [chemical binding]; other site 696748001639 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 696748001640 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 696748001641 active site 696748001642 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 696748001643 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 696748001644 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 696748001645 putative metal binding site; other site 696748001646 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 696748001647 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 696748001648 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 696748001649 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 696748001650 putative active site [active] 696748001651 argininosuccinate synthase; Validated; Region: PRK05370 696748001652 argininosuccinate synthase; Provisional; Region: PRK13820 696748001653 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 696748001654 RNA/DNA hybrid binding site [nucleotide binding]; other site 696748001655 active site 696748001656 Colicin V production protein; Region: Colicin_V; cl00567 696748001657 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 696748001658 amidophosphoribosyltransferase; Provisional; Region: PRK09246 696748001659 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 696748001660 active site 696748001661 tetramer interface [polypeptide binding]; other site 696748001662 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 696748001663 active site 696748001664 Predicted CRISPR-associated nuclease, contains McrA/HNH-nuclease and RuvC-like nuclease domain [Defense mechanisms]; Region: COG3513 696748001665 CRISPR/Cas system-associated protein Cas9; Region: Csn1; cd09643 696748001666 CRISPR/Cas system-associated protein Cas1; Region: Cas1_II; cd09720 696748001667 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638 696748001668 glutamate dehydrogenase; Provisional; Region: PRK09414 696748001669 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 696748001670 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 696748001671 NAD(P) binding site [chemical binding]; other site 696748001672 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 696748001673 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 696748001674 Nucleoid-associated protein [General function prediction only]; Region: COG3081 696748001675 nucleoid-associated protein NdpA; Validated; Region: PRK00378 696748001676 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 696748001677 homotrimer interaction site [polypeptide binding]; other site 696748001678 putative active site [active] 696748001679 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 696748001680 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 696748001681 integrase; Provisional; Region: int; PHA02601 696748001682 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 696748001683 active site 696748001684 DNA binding site [nucleotide binding] 696748001685 Int/Topo IB signature motif; other site 696748001686 DNA repair and recombination protein RadA; Validated; Region: radA; PRK04301 696748001687 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 696748001688 cofactor binding site; other site 696748001689 substrate interaction site [chemical binding]; other site 696748001690 Protein of unknown function (DUF551); Region: DUF551; pfam04448 696748001691 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Deinococcus radiodurans DR2231 protein and its bacterial homologs; Region: NTP-PPase_DR2231_like; cd11530 696748001692 metal binding site [ion binding]; metal-binding site 696748001693 Uncharacterized conserved protein (DUF2303); Region: DUF2303; cl02338 696748001694 Domain of unknown function (DUF4325); Region: DUF4325; pfam14213 696748001695 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 696748001696 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 696748001697 non-specific DNA binding site [nucleotide binding]; other site 696748001698 salt bridge; other site 696748001699 sequence-specific DNA binding site [nucleotide binding]; other site 696748001700 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 696748001701 Catalytic site [active] 696748001702 Uncharacterized protein conserved in bacteria, prophage-related [Function unknown]; Region: COG4197 696748001703 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 696748001704 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 696748001705 Conserved phage C-terminus (Phg_2220_C); Region: Phg_2220_C; cl09752 696748001706 DNA N-6-adenine-methyltransferase (Dam); Region: Dam; cl05442 696748001707 Protein of unknown function (DUF968); Region: DUF968; pfam06147 696748001708 Endodeoxyribonuclease RusA; Region: RusA; cl01885 696748001709 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 696748001710 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 696748001711 catalytic residues [active] 696748001712 Protein of unknown function (DUF2570); Region: DUF2570; pfam10828 696748001713 Protein of unknown function (DUF1441); Region: DUF1441; pfam07278 696748001714 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876 696748001715 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 696748001716 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 696748001717 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 696748001718 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 696748001719 oligomer interface [polypeptide binding]; other site 696748001720 active site residues [active] 696748001721 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 696748001722 Uncharacterized conserved protein (DUF2190); Region: DUF2190; pfam09956 696748001723 ATP-binding sugar transporter from pro-phage; Region: Gifsy-2; pfam13856 696748001724 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 696748001725 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 696748001726 Protein of unknown function (DUF4035); Region: DUF4035; pfam13227 696748001727 Phage-related minor tail protein [Function unknown]; Region: COG5281 696748001728 tape measure domain; Region: tape_meas_nterm; TIGR02675 696748001729 Tail length tape measure protein; Region: Phage_HK97_TLTM; pfam06120 696748001730 phage tail tape measure protein, lambda family; Region: tape_meas_lam_C; TIGR01541 696748001731 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 696748001732 Phage minor tail protein; Region: Phage_min_tail; cl01940 696748001733 Phage-related protein [Function unknown]; Region: gp18; COG4672 696748001734 YcfA-like protein; Region: YcfA; pfam07927 696748001735 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 696748001736 MPN+ (JAMM) motif; other site 696748001737 Zinc-binding site [ion binding]; other site 696748001738 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 696748001739 NlpC/P60 family; Region: NLPC_P60; cl17555 696748001740 Phage-related protein, tail component [Function unknown]; Region: COG4723 696748001741 Phage-related protein, tail component [Function unknown]; Region: COG4733 696748001742 Putative phage tail protein; Region: Phage-tail_3; pfam13550 696748001743 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 696748001744 TolA protein; Region: tolA_full; TIGR02794 696748001745 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 696748001746 integrase; Provisional; Region: PRK09692 696748001747 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 696748001748 active site 696748001749 Int/Topo IB signature motif; other site 696748001750 Fic family protein [Function unknown]; Region: COG3177 696748001751 Fic/DOC family; Region: Fic; pfam02661 696748001752 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 696748001753 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 696748001754 potential frameshift: common BLAST hit: gi|378775168|ref|YP_005177411.1| putative phage regulatory protein Rha family 696748001755 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 696748001756 nucleotide binding site [chemical binding]; other site 696748001757 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 696748001758 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 696748001759 putative N- and C-terminal domain interface [polypeptide binding]; other site 696748001760 putative active site [active] 696748001761 putative xylulose binding site [chemical binding]; other site 696748001762 MgATP binding site [chemical binding]; other site 696748001763 Terminase small subunit; Region: Terminase_2; cl01513 696748001764 Ash protein family; Region: Phage_ASH; pfam10554 696748001765 Superfamily II helicase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG5519 696748001766 Protein of unknown function (DUF1375); Region: DUF1375; pfam07119 696748001767 tartrate dehydrogenase; Provisional; Region: PRK08194 696748001768 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 696748001769 methionine sulfoxide reductase B; Provisional; Region: PRK00222 696748001770 SelR domain; Region: SelR; pfam01641 696748001771 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 696748001772 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 696748001773 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 696748001774 rod shape-determining protein MreB; Provisional; Region: PRK13927 696748001775 MreB and similar proteins; Region: MreB_like; cd10225 696748001776 nucleotide binding site [chemical binding]; other site 696748001777 Mg binding site [ion binding]; other site 696748001778 putative protofilament interaction site [polypeptide binding]; other site 696748001779 RodZ interaction site [polypeptide binding]; other site 696748001780 rod shape-determining protein MreC; Region: mreC; TIGR00219 696748001781 rod shape-determining protein MreC; Region: MreC; pfam04085 696748001782 rod shape-determining protein MreD; Region: MreD; cl01087 696748001783 recombination factor protein RarA; Reviewed; Region: PRK13342 696748001784 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 696748001785 Walker A motif; other site 696748001786 ATP binding site [chemical binding]; other site 696748001787 Walker B motif; other site 696748001788 arginine finger; other site 696748001789 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 696748001790 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 696748001791 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 696748001792 ABC-ATPase subunit interface; other site 696748001793 dimer interface [polypeptide binding]; other site 696748001794 putative PBP binding regions; other site 696748001795 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 696748001796 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 696748001797 putative active site [active] 696748001798 putative dimer interface [polypeptide binding]; other site 696748001799 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 696748001800 homotrimer interaction site [polypeptide binding]; other site 696748001801 zinc binding site [ion binding]; other site 696748001802 CDP-binding sites; other site 696748001803 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 696748001804 substrate binding site; other site 696748001805 dimer interface; other site 696748001806 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 696748001807 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 696748001808 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 696748001809 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 696748001810 active site 696748001811 substrate-binding site [chemical binding]; other site 696748001812 metal-binding site [ion binding] 696748001813 ATP binding site [chemical binding]; other site 696748001814 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 696748001815 CoA binding domain; Region: CoA_binding; smart00881 696748001816 CoA-ligase; Region: Ligase_CoA; pfam00549 696748001817 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 696748001818 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 696748001819 CoA-ligase; Region: Ligase_CoA; pfam00549 696748001820 Protein of unknown function (DUF535); Region: DUF535; pfam04393 696748001821 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 696748001822 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 696748001823 E3 interaction surface; other site 696748001824 lipoyl attachment site [posttranslational modification]; other site 696748001825 e3 binding domain; Region: E3_binding; pfam02817 696748001826 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 696748001827 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 696748001828 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 696748001829 TPP-binding site [chemical binding]; other site 696748001830 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 696748001831 dimer interface [polypeptide binding]; other site 696748001832 PYR/PP interface [polypeptide binding]; other site 696748001833 TPP binding site [chemical binding]; other site 696748001834 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 696748001835 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 696748001836 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 696748001837 putative peptidase; Provisional; Region: PRK11649 696748001838 Peptidase family M23; Region: Peptidase_M23; pfam01551 696748001839 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 696748001840 dimerization domain [polypeptide binding]; other site 696748001841 dimer interface [polypeptide binding]; other site 696748001842 catalytic residues [active] 696748001843 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 696748001844 DHH family; Region: DHH; pfam01368 696748001845 DHHA1 domain; Region: DHHA1; pfam02272 696748001846 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 696748001847 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 696748001848 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 696748001849 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 696748001850 ligand binding site [chemical binding]; other site 696748001851 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 696748001852 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 696748001853 active site 696748001854 motif I; other site 696748001855 motif II; other site 696748001856 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 696748001857 motif II; other site 696748001858 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 696748001859 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 696748001860 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 696748001861 dimerization interface [polypeptide binding]; other site 696748001862 Histidine kinase; Region: HisKA_3; pfam07730 696748001863 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 696748001864 ATP binding site [chemical binding]; other site 696748001865 Mg2+ binding site [ion binding]; other site 696748001866 G-X-G motif; other site 696748001867 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 696748001868 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 696748001869 Coenzyme A binding pocket [chemical binding]; other site 696748001870 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 696748001871 active site 696748001872 dimerization interface [polypeptide binding]; other site 696748001873 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 696748001874 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 696748001875 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 696748001876 Potassium binding sites [ion binding]; other site 696748001877 Cesium cation binding sites [ion binding]; other site 696748001878 hypothetical protein; Provisional; Region: PRK05170 696748001879 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696748001880 malonic semialdehyde reductase; Provisional; Region: PRK10538 696748001881 NAD(P) binding site [chemical binding]; other site 696748001882 active site 696748001883 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 696748001884 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 696748001885 pyridoxal 5'-phosphate binding site [chemical binding]; other site 696748001886 catalytic residue [active] 696748001887 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 696748001888 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 696748001889 substrate binding site [chemical binding]; other site 696748001890 active site 696748001891 catalytic residues [active] 696748001892 heterodimer interface [polypeptide binding]; other site 696748001893 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 696748001894 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 696748001895 ATP binding site [chemical binding]; other site 696748001896 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 696748001897 LrgA family; Region: LrgA; cl00608 696748001898 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 696748001899 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 696748001900 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 696748001901 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 696748001902 Walker A/P-loop; other site 696748001903 ATP binding site [chemical binding]; other site 696748001904 Q-loop/lid; other site 696748001905 ABC transporter signature motif; other site 696748001906 Walker B; other site 696748001907 D-loop; other site 696748001908 H-loop/switch region; other site 696748001909 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 696748001910 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 696748001911 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 696748001912 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 696748001913 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 696748001914 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 696748001915 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 696748001916 active site 696748001917 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 696748001918 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 696748001919 quinone interaction residues [chemical binding]; other site 696748001920 active site 696748001921 catalytic residues [active] 696748001922 FMN binding site [chemical binding]; other site 696748001923 substrate binding site [chemical binding]; other site 696748001924 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 696748001925 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 696748001926 dimer interface [polypeptide binding]; other site 696748001927 TPP-binding site [chemical binding]; other site 696748001928 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 696748001929 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 696748001930 E3 interaction surface; other site 696748001931 lipoyl attachment site [posttranslational modification]; other site 696748001932 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 696748001933 E3 interaction surface; other site 696748001934 lipoyl attachment site [posttranslational modification]; other site 696748001935 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 696748001936 E3 interaction surface; other site 696748001937 lipoyl attachment site [posttranslational modification]; other site 696748001938 e3 binding domain; Region: E3_binding; pfam02817 696748001939 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 696748001940 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 696748001941 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 696748001942 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 696748001943 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 696748001944 Domain of unknown function (DUF4298); Region: DUF4298; pfam14131 696748001945 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 696748001946 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 696748001947 active site 696748001948 metal binding site [ion binding]; metal-binding site 696748001949 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 696748001950 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 696748001951 serine/threonine transporter SstT; Provisional; Region: PRK13628 696748001952 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 696748001953 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 696748001954 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 696748001955 Competence protein; Region: Competence; pfam03772 696748001956 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 696748001957 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 696748001958 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 696748001959 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 696748001960 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 696748001961 phosphate binding site [ion binding]; other site 696748001962 putative substrate binding pocket [chemical binding]; other site 696748001963 dimer interface [polypeptide binding]; other site 696748001964 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 696748001965 Domain of unknown function DUF20; Region: UPF0118; pfam01594 696748001966 Methyltransferase domain; Region: Methyltransf_31; pfam13847 696748001967 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 696748001968 S-adenosylmethionine binding site [chemical binding]; other site 696748001969 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036 696748001970 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 696748001971 Predicted phage phi-C31 gp36 major capsid-like protein [General function prediction only]; Region: COG4653 696748001972 Phage capsid family; Region: Phage_capsid; pfam05065 696748001973 Phage head maturation protease [General function prediction only]; Region: COG3740 696748001974 Phage-related protein [Function unknown]; Region: COG4695 696748001975 Phage portal protein; Region: Phage_portal; pfam04860 696748001976 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 696748001977 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 696748001978 oligomerization interface [polypeptide binding]; other site 696748001979 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 696748001980 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 696748001981 active site 696748001982 Phage terminase, small subunit; Region: Terminase_4; cl01525 696748001983 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 696748001984 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 696748001985 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 696748001986 Ash protein family; Region: Phage_ASH; pfam10554 696748001987 D5 N terminal like; Region: D5_N; pfam08706 696748001988 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 696748001989 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 696748001990 integrase; Provisional; Region: PRK09692 696748001991 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 696748001992 active site 696748001993 Int/Topo IB signature motif; other site 696748001994 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 696748001995 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 696748001996 active site 696748001997 metal binding site [ion binding]; metal-binding site 696748001998 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 696748001999 LrgA family; Region: LrgA; cl00608 696748002000 exoribonuclease II; Provisional; Region: PRK05054 696748002001 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 696748002002 RNB domain; Region: RNB; pfam00773 696748002003 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 696748002004 RNA binding site [nucleotide binding]; other site 696748002005 Domain of unknown function (DUF4415); Region: DUF4415; pfam14384 696748002006 Protein of unknown function (DUF497); Region: DUF497; cl01108 696748002007 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 696748002008 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 696748002009 NAD binding site [chemical binding]; other site 696748002010 homotetramer interface [polypeptide binding]; other site 696748002011 homodimer interface [polypeptide binding]; other site 696748002012 substrate binding site [chemical binding]; other site 696748002013 active site 696748002014 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 696748002015 S-adenosylmethionine binding site [chemical binding]; other site 696748002016 acyl-CoA esterase; Provisional; Region: PRK10673 696748002017 PGAP1-like protein; Region: PGAP1; pfam07819 696748002018 replication initiation regulator SeqA; Provisional; Region: PRK11187 696748002019 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 696748002020 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 696748002021 acyl-activating enzyme (AAE) consensus motif; other site 696748002022 putative AMP binding site [chemical binding]; other site 696748002023 putative active site [active] 696748002024 putative CoA binding site [chemical binding]; other site 696748002025 hypothetical protein; Provisional; Region: PRK11281 696748002026 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 696748002027 Mechanosensitive ion channel; Region: MS_channel; pfam00924 696748002028 hypothetical protein; Provisional; Region: PRK11281 696748002029 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 696748002030 Mechanosensitive ion channel; Region: MS_channel; pfam00924 696748002031 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 696748002032 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 696748002033 Tetramer interface [polypeptide binding]; other site 696748002034 active site 696748002035 FMN-binding site [chemical binding]; other site 696748002036 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 696748002037 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 696748002038 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 696748002039 active site 696748002040 dimer interface [polypeptide binding]; other site 696748002041 DNA topoisomerase III; Provisional; Region: PRK07726 696748002042 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 696748002043 active site 696748002044 putative interdomain interaction site [polypeptide binding]; other site 696748002045 putative metal-binding site [ion binding]; other site 696748002046 putative nucleotide binding site [chemical binding]; other site 696748002047 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 696748002048 domain I; other site 696748002049 DNA binding groove [nucleotide binding] 696748002050 phosphate binding site [ion binding]; other site 696748002051 domain II; other site 696748002052 domain III; other site 696748002053 nucleotide binding site [chemical binding]; other site 696748002054 catalytic site [active] 696748002055 domain IV; other site 696748002056 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 696748002057 serine endoprotease; Provisional; Region: PRK10898 696748002058 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 696748002059 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 696748002060 cytidylate kinase; Provisional; Region: cmk; PRK00023 696748002061 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 696748002062 CMP-binding site; other site 696748002063 The sites determining sugar specificity; other site 696748002064 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 696748002065 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 696748002066 RNA binding site [nucleotide binding]; other site 696748002067 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 696748002068 RNA binding site [nucleotide binding]; other site 696748002069 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 696748002070 RNA binding site [nucleotide binding]; other site 696748002071 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 696748002072 RNA binding site [nucleotide binding]; other site 696748002073 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 696748002074 RNA binding site [nucleotide binding]; other site 696748002075 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 696748002076 RNA binding site [nucleotide binding]; other site 696748002077 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 696748002078 IHF dimer interface [polypeptide binding]; other site 696748002079 IHF - DNA interface [nucleotide binding]; other site 696748002080 Predicted membrane protein [Function unknown]; Region: COG3771 696748002081 tetratricopeptide repeat protein; Provisional; Region: PRK11788 696748002082 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 696748002083 binding surface 696748002084 TPR motif; other site 696748002085 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 696748002086 TPR motif; other site 696748002087 binding surface 696748002088 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 696748002089 active site 696748002090 dimer interface [polypeptide binding]; other site 696748002091 translation initiation factor Sui1; Validated; Region: PRK06824 696748002092 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 696748002093 putative rRNA binding site [nucleotide binding]; other site 696748002094 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3787; cl17897 696748002095 Protein of unknown function (DUF554); Region: DUF554; pfam04474 696748002096 aromatic acid decarboxylase; Validated; Region: PRK05920 696748002097 Flavoprotein; Region: Flavoprotein; pfam02441 696748002098 Invasion gene expression up-regulator, SirB; Region: SirB; pfam04247 696748002099 hypothetical protein; Provisional; Region: PRK05255 696748002100 peptidase PmbA; Provisional; Region: PRK11040 696748002101 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 696748002102 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 696748002103 putative valine binding site [chemical binding]; other site 696748002104 dimer interface [polypeptide binding]; other site 696748002105 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 696748002106 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06882 696748002107 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 696748002108 PYR/PP interface [polypeptide binding]; other site 696748002109 dimer interface [polypeptide binding]; other site 696748002110 TPP binding site [chemical binding]; other site 696748002111 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 696748002112 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 696748002113 TPP-binding site [chemical binding]; other site 696748002114 dimer interface [polypeptide binding]; other site 696748002115 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 696748002116 active site clefts [active] 696748002117 zinc binding site [ion binding]; other site 696748002118 dimer interface [polypeptide binding]; other site 696748002119 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 696748002120 DNA-binding site [nucleotide binding]; DNA binding site 696748002121 RNA-binding motif; other site 696748002122 Protein of unknown function (DUF1439); Region: DUF1439; pfam07273 696748002123 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 696748002124 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 696748002125 Hemerythrin-like domain; Region: Hr-like; cd12108 696748002126 Fe binding site [ion binding]; other site 696748002127 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 696748002128 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 696748002129 Bacterial SH3 domain homologues; Region: SH3b; smart00287 696748002130 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 696748002131 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 696748002132 Protein of unknown function DUF47; Region: PhoU_div; pfam01865 696748002133 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 696748002134 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 696748002135 Walker A/P-loop; other site 696748002136 ATP binding site [chemical binding]; other site 696748002137 Q-loop/lid; other site 696748002138 ABC transporter signature motif; other site 696748002139 Walker B; other site 696748002140 D-loop; other site 696748002141 H-loop/switch region; other site 696748002142 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 696748002143 ABC-ATPase subunit interface; other site 696748002144 dimer interface [polypeptide binding]; other site 696748002145 putative PBP binding regions; other site 696748002146 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 696748002147 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 696748002148 ABC-ATPase subunit interface; other site 696748002149 dimer interface [polypeptide binding]; other site 696748002150 putative PBP binding regions; other site 696748002151 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 696748002152 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 696748002153 putative ligand binding residues [chemical binding]; other site 696748002154 replicative DNA helicase; Validated; Region: PRK06904 696748002155 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 696748002156 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 696748002157 Walker A motif; other site 696748002158 ATP binding site [chemical binding]; other site 696748002159 Walker B motif; other site 696748002160 DNA binding loops [nucleotide binding] 696748002161 YcgL domain; Region: YcgL; pfam05166 696748002162 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 696748002163 ATP cone domain; Region: ATP-cone; pfam03477 696748002164 aspartate kinase III; Validated; Region: PRK09084 696748002165 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 696748002166 nucleotide binding site [chemical binding]; other site 696748002167 substrate binding site [chemical binding]; other site 696748002168 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_1; cd04932 696748002169 dimer interface [polypeptide binding]; other site 696748002170 lysine allosteric regulatory site; other site 696748002171 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 696748002172 dimer interface [polypeptide binding]; other site 696748002173 hypothetical protein; Provisional; Region: PRK05423 696748002174 exopolyphosphatase; Provisional; Region: PRK10854 696748002175 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 696748002176 Domain of unknown function (DUF386); Region: DUF386; cl01047 696748002177 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 696748002178 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 696748002179 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 696748002180 putative active site [active] 696748002181 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 696748002182 homodimer interface [polypeptide binding]; other site 696748002183 substrate-cofactor binding pocket; other site 696748002184 pyridoxal 5'-phosphate binding site [chemical binding]; other site 696748002185 catalytic residue [active] 696748002186 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 696748002187 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 696748002188 pyridoxal 5'-phosphate binding site [chemical binding]; other site 696748002189 homodimer interface [polypeptide binding]; other site 696748002190 catalytic residue [active] 696748002191 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 696748002192 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 696748002193 hinge; other site 696748002194 active site 696748002195 N-acetylglutamate synthase; Validated; Region: PRK05279 696748002196 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 696748002197 putative feedback inhibition sensing region; other site 696748002198 putative nucleotide binding site [chemical binding]; other site 696748002199 putative substrate binding site [chemical binding]; other site 696748002200 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 696748002201 Coenzyme A binding pocket [chemical binding]; other site 696748002202 Transcriptional regulator [Transcription]; Region: LysR; COG0583 696748002203 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 696748002204 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 696748002205 putative effector binding pocket; other site 696748002206 dimerization interface [polypeptide binding]; other site 696748002207 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 696748002208 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 696748002209 active site 696748002210 interdomain interaction site; other site 696748002211 putative metal-binding site [ion binding]; other site 696748002212 nucleotide binding site [chemical binding]; other site 696748002213 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 696748002214 domain I; other site 696748002215 DNA binding groove [nucleotide binding] 696748002216 phosphate binding site [ion binding]; other site 696748002217 domain II; other site 696748002218 domain III; other site 696748002219 nucleotide binding site [chemical binding]; other site 696748002220 catalytic site [active] 696748002221 domain IV; other site 696748002222 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 696748002223 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 696748002224 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 696748002225 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 696748002226 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 696748002227 Helicase; Region: Helicase_RecD; pfam05127 696748002228 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 696748002229 metal-binding heat shock protein; Provisional; Region: PRK00016 696748002230 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 696748002231 MoaE homodimer interface [polypeptide binding]; other site 696748002232 MoaD interaction [polypeptide binding]; other site 696748002233 active site residues [active] 696748002234 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 696748002235 MoaE interaction surface [polypeptide binding]; other site 696748002236 MoeB interaction surface [polypeptide binding]; other site 696748002237 thiocarboxylated glycine; other site 696748002238 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 696748002239 trimer interface [polypeptide binding]; other site 696748002240 dimer interface [polypeptide binding]; other site 696748002241 putative active site [active] 696748002242 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 696748002243 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 696748002244 FeS/SAM binding site; other site 696748002245 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 696748002246 trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162 696748002247 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 696748002248 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 696748002249 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 696748002250 molybdopterin cofactor binding site [chemical binding]; other site 696748002251 substrate binding site [chemical binding]; other site 696748002252 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 696748002253 molybdopterin cofactor binding site; other site 696748002254 Protein of unknown function (DUF423); Region: DUF423; cl01008 696748002255 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 696748002256 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 696748002257 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 696748002258 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 696748002259 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 696748002260 cystathionine gamma-synthase; Reviewed; Region: PRK08247 696748002261 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 696748002262 homodimer interface [polypeptide binding]; other site 696748002263 substrate-cofactor binding pocket; other site 696748002264 pyridoxal 5'-phosphate binding site [chemical binding]; other site 696748002265 catalytic residue [active] 696748002266 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 696748002267 active site 696748002268 lytic murein transglycosylase; Provisional; Region: PRK11619 696748002269 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 696748002270 N-acetyl-D-glucosamine binding site [chemical binding]; other site 696748002271 catalytic residue [active] 696748002272 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 696748002273 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 696748002274 active site 696748002275 HIGH motif; other site 696748002276 nucleotide binding site [chemical binding]; other site 696748002277 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 696748002278 KMSKS motif; other site 696748002279 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 696748002280 isocitrate dehydrogenase; Validated; Region: PRK07362 696748002281 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 696748002282 elongation factor P; Validated; Region: PRK00529 696748002283 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 696748002284 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 696748002285 RNA binding site [nucleotide binding]; other site 696748002286 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 696748002287 RNA binding site [nucleotide binding]; other site 696748002288 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 696748002289 FeS/SAM binding site; other site 696748002290 Radical SAM superfamily; Region: Radical_SAM; pfam04055 696748002291 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 696748002292 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 696748002293 putative dimer interface [polypeptide binding]; other site 696748002294 putative anticodon binding site; other site 696748002295 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 696748002296 homodimer interface [polypeptide binding]; other site 696748002297 motif 1; other site 696748002298 motif 2; other site 696748002299 active site 696748002300 motif 3; other site 696748002301 exonuclease I; Provisional; Region: sbcB; PRK11779 696748002302 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 696748002303 active site 696748002304 catalytic site [active] 696748002305 substrate binding site [chemical binding]; other site 696748002306 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 696748002307 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 696748002308 putative active site [active] 696748002309 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 696748002310 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 696748002311 active site 696748002312 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 696748002313 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 696748002314 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 696748002315 Imelysin; Region: Peptidase_M75; pfam09375 696748002316 excinuclease ABC subunit B; Provisional; Region: PRK05298 696748002317 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 696748002318 ATP binding site [chemical binding]; other site 696748002319 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 696748002320 nucleotide binding region [chemical binding]; other site 696748002321 ATP-binding site [chemical binding]; other site 696748002322 Ultra-violet resistance protein B; Region: UvrB; pfam12344 696748002323 AAA domain; Region: AAA_14; pfam13173 696748002324 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 696748002325 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 696748002326 proline aminopeptidase P II; Provisional; Region: PRK10879 696748002327 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 696748002328 active site 696748002329 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 696748002330 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 696748002331 pyridoxal 5'-phosphate binding site [chemical binding]; other site 696748002332 homodimer interface [polypeptide binding]; other site 696748002333 catalytic residue [active] 696748002334 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 696748002335 ATP-grasp domain; Region: ATP-grasp; pfam02222 696748002336 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 696748002337 active site 696748002338 homodimer interface [polypeptide binding]; other site 696748002339 homotetramer interface [polypeptide binding]; other site 696748002340 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 696748002341 stringent starvation protein A; Provisional; Region: sspA; PRK09481 696748002342 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 696748002343 C-terminal domain interface [polypeptide binding]; other site 696748002344 putative GSH binding site (G-site) [chemical binding]; other site 696748002345 dimer interface [polypeptide binding]; other site 696748002346 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 696748002347 dimer interface [polypeptide binding]; other site 696748002348 N-terminal domain interface [polypeptide binding]; other site 696748002349 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 696748002350 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 696748002351 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 696748002352 ligand binding site [chemical binding]; other site 696748002353 flexible hinge region; other site 696748002354 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 696748002355 putative switch regulator; other site 696748002356 non-specific DNA interactions [nucleotide binding]; other site 696748002357 DNA binding site [nucleotide binding] 696748002358 sequence specific DNA binding site [nucleotide binding]; other site 696748002359 putative cAMP binding site [chemical binding]; other site 696748002360 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 696748002361 Ligand Binding Site [chemical binding]; other site 696748002362 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 696748002363 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 696748002364 motif 1; other site 696748002365 active site 696748002366 motif 2; other site 696748002367 motif 3; other site 696748002368 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 696748002369 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 696748002370 DHHA1 domain; Region: DHHA1; pfam02272 696748002371 carbon storage regulator; Provisional; Region: PRK01712 696748002372 potential frameshift: common BLAST hit: gi|165976062|ref|YP_001651655.1| phosphomannomutase 696748002373 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 696748002374 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 696748002375 active site 696748002376 tetramer interface; other site 696748002377 Primosomal replication protein priB and priC; Region: priB_priC; cl11483 696748002378 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 696748002379 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 696748002380 trimer interface [polypeptide binding]; other site 696748002381 eyelet of channel; other site 696748002382 putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198 696748002383 pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569 696748002384 active site 696748002385 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 696748002386 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 696748002387 active site 696748002388 metal binding site [ion binding]; metal-binding site 696748002389 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 696748002390 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 696748002391 propionate/acetate kinase; Provisional; Region: PRK12379 696748002392 phosphate acetyltransferase; Reviewed; Region: PRK05632 696748002393 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 696748002394 DRTGG domain; Region: DRTGG; pfam07085 696748002395 phosphate acetyltransferase; Region: pta; TIGR00651 696748002396 Domain of unknown function (DUF1508); Region: DUF1508; cl01356 696748002397 D-lactate dehydrogenase; Provisional; Region: PRK11183 696748002398 FAD binding domain; Region: FAD_binding_4; pfam01565 696748002399 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 696748002400 Transglycosylase SLT domain; Region: SLT_2; pfam13406 696748002401 murein hydrolase B; Provisional; Region: PRK10760; cl17906 696748002402 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 696748002403 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 696748002404 RNA binding site [nucleotide binding]; other site 696748002405 active site 696748002406 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 696748002407 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 696748002408 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 696748002409 translation initiation factor IF-2; Region: IF-2; TIGR00487 696748002410 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 696748002411 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 696748002412 G1 box; other site 696748002413 putative GEF interaction site [polypeptide binding]; other site 696748002414 GTP/Mg2+ binding site [chemical binding]; other site 696748002415 Switch I region; other site 696748002416 G2 box; other site 696748002417 G3 box; other site 696748002418 Switch II region; other site 696748002419 G4 box; other site 696748002420 G5 box; other site 696748002421 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 696748002422 Translation-initiation factor 2; Region: IF-2; pfam11987 696748002423 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 696748002424 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 696748002425 NusA N-terminal domain; Region: NusA_N; pfam08529 696748002426 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 696748002427 RNA binding site [nucleotide binding]; other site 696748002428 homodimer interface [polypeptide binding]; other site 696748002429 NusA-like KH domain; Region: KH_5; pfam13184 696748002430 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 696748002431 G-X-X-G motif; other site 696748002432 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 696748002433 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 696748002434 ribosome maturation protein RimP; Reviewed; Region: PRK00092 696748002435 Sm and related proteins; Region: Sm_like; cl00259 696748002436 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 696748002437 putative oligomer interface [polypeptide binding]; other site 696748002438 putative RNA binding site [nucleotide binding]; other site 696748002439 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 696748002440 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 696748002441 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 696748002442 ATP binding site [chemical binding]; other site 696748002443 putative Mg++ binding site [ion binding]; other site 696748002444 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 696748002445 Abortive infection C-terminus; Region: Abi_C; pfam14355 696748002446 Protein of unknown function (DUF3574); Region: DUF3574; pfam12098 696748002447 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 696748002448 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 696748002449 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 696748002450 HsdM N-terminal domain; Region: HsdM_N; pfam12161 696748002451 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 696748002452 Methyltransferase domain; Region: Methyltransf_26; pfam13659 696748002453 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 696748002454 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 696748002455 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 696748002456 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 696748002457 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 696748002458 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 696748002459 homodimer interface [polypeptide binding]; other site 696748002460 metal binding site [ion binding]; metal-binding site 696748002461 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 696748002462 homodimer interface [polypeptide binding]; other site 696748002463 active site 696748002464 putative chemical substrate binding site [chemical binding]; other site 696748002465 metal binding site [ion binding]; metal-binding site 696748002466 DNA-binding response regulator CreB; Provisional; Region: PRK11083 696748002467 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 696748002468 active site 696748002469 phosphorylation site [posttranslational modification] 696748002470 intermolecular recognition site; other site 696748002471 dimerization interface [polypeptide binding]; other site 696748002472 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 696748002473 DNA binding site [nucleotide binding] 696748002474 two-component sensor protein; Provisional; Region: cpxA; PRK09470 696748002475 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 696748002476 dimerization interface [polypeptide binding]; other site 696748002477 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 696748002478 dimer interface [polypeptide binding]; other site 696748002479 phosphorylation site [posttranslational modification] 696748002480 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 696748002481 ATP binding site [chemical binding]; other site 696748002482 Mg2+ binding site [ion binding]; other site 696748002483 G-X-G motif; other site 696748002484 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 696748002485 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 696748002486 Walker A/P-loop; other site 696748002487 ATP binding site [chemical binding]; other site 696748002488 Q-loop/lid; other site 696748002489 ABC transporter signature motif; other site 696748002490 Walker B; other site 696748002491 D-loop; other site 696748002492 H-loop/switch region; other site 696748002493 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 696748002494 FtsX-like permease family; Region: FtsX; pfam02687 696748002495 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 696748002496 Uncharacterized conserved protein [Function unknown]; Region: COG0327 696748002497 Fructose-1,6-bisphosphatase/sedoheptulose 1,7-bisphosphatase and related proteins [Carbohydrate transport and metabolism]; Region: GlpX; COG1494 696748002498 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 696748002499 active site 696748002500 thymidine kinase; Provisional; Region: PRK04296 696748002501 sugar efflux transporter B; Provisional; Region: PRK15011 696748002502 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696748002503 putative substrate translocation pore; other site 696748002504 Glycoprotease family; Region: Peptidase_M22; pfam00814 696748002505 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 696748002506 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 696748002507 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 696748002508 Predicted metalloprotease [General function prediction only]; Region: COG2321 696748002509 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 696748002510 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 696748002511 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 696748002512 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 696748002513 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 696748002514 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 696748002515 dimerization interface [polypeptide binding]; other site 696748002516 putative DNA binding site [nucleotide binding]; other site 696748002517 putative Zn2+ binding site [ion binding]; other site 696748002518 AsnC family; Region: AsnC_trans_reg; pfam01037 696748002519 ribonuclease D; Provisional; Region: PRK10829 696748002520 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 696748002521 catalytic site [active] 696748002522 putative active site [active] 696748002523 putative substrate binding site [chemical binding]; other site 696748002524 HRDC domain; Region: HRDC; pfam00570 696748002525 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 696748002526 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 696748002527 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 696748002528 AAA domain; Region: AAA_26; pfam13500 696748002529 NlpC/P60 family; Region: NLPC_P60; pfam00877 696748002530 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 696748002531 IHF dimer interface [polypeptide binding]; other site 696748002532 IHF - DNA interface [nucleotide binding]; other site 696748002533 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 696748002534 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 696748002535 putative tRNA-binding site [nucleotide binding]; other site 696748002536 B3/4 domain; Region: B3_4; pfam03483 696748002537 tRNA synthetase B5 domain; Region: B5; smart00874 696748002538 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 696748002539 dimer interface [polypeptide binding]; other site 696748002540 motif 1; other site 696748002541 motif 3; other site 696748002542 motif 2; other site 696748002543 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 696748002544 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 696748002545 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 696748002546 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 696748002547 dimer interface [polypeptide binding]; other site 696748002548 motif 1; other site 696748002549 active site 696748002550 motif 2; other site 696748002551 motif 3; other site 696748002552 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 696748002553 dimer interface [polypeptide binding]; other site 696748002554 FMN binding site [chemical binding]; other site 696748002555 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 696748002556 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 696748002557 Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310); Region: DUF2310; pfam10071 696748002558 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 696748002559 Cation efflux family; Region: Cation_efflux; cl00316 696748002560 hypothetical protein; Validated; Region: PRK02101 696748002561 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 696748002562 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 696748002563 23S rRNA interface [nucleotide binding]; other site 696748002564 L3 interface [polypeptide binding]; other site 696748002565 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 696748002566 Protein of unknown function (DUF1043); Region: DUF1043; cl11473 696748002567 PII uridylyl-transferase; Provisional; Region: glnD; PRK01759 696748002568 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 696748002569 metal binding triad; other site 696748002570 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 696748002571 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 696748002572 Zn2+ binding site [ion binding]; other site 696748002573 Mg2+ binding site [ion binding]; other site 696748002574 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 696748002575 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 696748002576 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 696748002577 aromatic amino acid transport protein; Region: araaP; TIGR00837 696748002578 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 696748002579 aromatic amino acid transport protein; Region: araaP; TIGR00837 696748002580 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 696748002581 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 696748002582 Walker A motif; other site 696748002583 ATP binding site [chemical binding]; other site 696748002584 Walker B motif; other site 696748002585 arginine finger; other site 696748002586 Peptidase family M41; Region: Peptidase_M41; pfam01434 696748002587 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 696748002588 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 696748002589 S-adenosylmethionine binding site [chemical binding]; other site 696748002590 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 696748002591 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 696748002592 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 696748002593 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 696748002594 active site 696748002595 GMP synthase; Reviewed; Region: guaA; PRK00074 696748002596 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 696748002597 AMP/PPi binding site [chemical binding]; other site 696748002598 candidate oxyanion hole; other site 696748002599 catalytic triad [active] 696748002600 potential glutamine specificity residues [chemical binding]; other site 696748002601 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 696748002602 ATP Binding subdomain [chemical binding]; other site 696748002603 Ligand Binding sites [chemical binding]; other site 696748002604 Dimerization subdomain; other site 696748002605 Uncharacterized conserved protein [Function unknown]; Region: COG4748 696748002606 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 696748002607 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 696748002608 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 696748002609 active site 696748002610 substrate binding site [chemical binding]; other site 696748002611 metal binding site [ion binding]; metal-binding site 696748002612 Domain of unknown function (DUF1919); Region: DUF1919; pfam08942 696748002613 Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357 696748002614 CHY zinc finger; Region: zf-CHY; pfam05495 696748002615 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 696748002616 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 696748002617 Substrate binding site; other site 696748002618 Mg++ binding site; other site 696748002619 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 696748002620 active site 696748002621 substrate binding site [chemical binding]; other site 696748002622 CoA binding site [chemical binding]; other site 696748002623 multidrug efflux protein; Reviewed; Region: PRK09579 696748002624 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 696748002625 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 696748002626 HlyD family secretion protein; Region: HlyD_3; pfam13437 696748002627 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 696748002628 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 696748002629 hypothetical protein; Provisional; Region: PRK13689 696748002630 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 696748002631 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 696748002632 Sulfatase; Region: Sulfatase; cl17466 696748002633 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 696748002634 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 696748002635 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 696748002636 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 696748002637 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 696748002638 DNA-binding site [nucleotide binding]; DNA binding site 696748002639 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 696748002640 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 696748002641 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 696748002642 substrate binding site [chemical binding]; other site 696748002643 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 696748002644 substrate binding site [chemical binding]; other site 696748002645 ligand binding site [chemical binding]; other site 696748002646 putative arabinose transporter; Provisional; Region: PRK03545 696748002647 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696748002648 putative substrate translocation pore; other site 696748002649 cell division protein MukB; Provisional; Region: mukB; PRK04863 696748002650 P-loop containing region of AAA domain; Region: AAA_29; cl17516 696748002651 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 696748002652 condesin subunit E; Provisional; Region: PRK05256 696748002653 condesin subunit F; Provisional; Region: PRK05260 696748002654 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 696748002655 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 696748002656 CAP-like domain; other site 696748002657 active site 696748002658 primary dimer interface [polypeptide binding]; other site 696748002659 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 696748002660 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 696748002661 RNase E interface [polypeptide binding]; other site 696748002662 trimer interface [polypeptide binding]; other site 696748002663 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 696748002664 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 696748002665 RNase E interface [polypeptide binding]; other site 696748002666 trimer interface [polypeptide binding]; other site 696748002667 active site 696748002668 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 696748002669 putative nucleic acid binding region [nucleotide binding]; other site 696748002670 G-X-X-G motif; other site 696748002671 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 696748002672 RNA binding site [nucleotide binding]; other site 696748002673 domain interface; other site 696748002674 Lipoprotein NlpI, contains TPR repeats [General function prediction only]; Region: NlpI; COG4785 696748002675 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 696748002676 binding surface 696748002677 TPR motif; other site 696748002678 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 696748002679 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 696748002680 ATP binding site [chemical binding]; other site 696748002681 Mg++ binding site [ion binding]; other site 696748002682 motif III; other site 696748002683 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 696748002684 nucleotide binding region [chemical binding]; other site 696748002685 ATP-binding site [chemical binding]; other site 696748002686 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 696748002687 putative RNA binding site [nucleotide binding]; other site 696748002688 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 696748002689 nucleoside/Zn binding site; other site 696748002690 dimer interface [polypeptide binding]; other site 696748002691 catalytic motif [active] 696748002692 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 696748002693 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142 696748002694 predicted active site [active] 696748002695 catalytic triad [active] 696748002696 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 696748002697 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 696748002698 active site 696748002699 multimer interface [polypeptide binding]; other site 696748002700 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 696748002701 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 696748002702 DNA-binding site [nucleotide binding]; DNA binding site 696748002703 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 696748002704 pyridoxal 5'-phosphate binding site [chemical binding]; other site 696748002705 homodimer interface [polypeptide binding]; other site 696748002706 catalytic residue [active] 696748002707 ribosome recycling factor; Reviewed; Region: frr; PRK00083 696748002708 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 696748002709 hinge region; other site 696748002710 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 696748002711 putative nucleotide binding site [chemical binding]; other site 696748002712 uridine monophosphate binding site [chemical binding]; other site 696748002713 homohexameric interface [polypeptide binding]; other site 696748002714 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 696748002715 Sulfatase; Region: Sulfatase; cl17466 696748002716 elongation factor Ts; Provisional; Region: tsf; PRK09377 696748002717 UBA/TS-N domain; Region: UBA; pfam00627 696748002718 Elongation factor TS; Region: EF_TS; pfam00889 696748002719 Elongation factor TS; Region: EF_TS; pfam00889 696748002720 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 696748002721 rRNA interaction site [nucleotide binding]; other site 696748002722 S8 interaction site; other site 696748002723 putative laminin-1 binding site; other site 696748002724 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 696748002725 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 696748002726 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 696748002727 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 696748002728 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 696748002729 N-terminal plug; other site 696748002730 ligand-binding site [chemical binding]; other site 696748002731 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 696748002732 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 696748002733 dimer interface [polypeptide binding]; other site 696748002734 conserved gate region; other site 696748002735 putative PBP binding loops; other site 696748002736 ABC-ATPase subunit interface; other site 696748002737 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 696748002738 dimer interface [polypeptide binding]; other site 696748002739 conserved gate region; other site 696748002740 putative PBP binding loops; other site 696748002741 ABC-ATPase subunit interface; other site 696748002742 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 696748002743 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 696748002744 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 696748002745 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 696748002746 Zonular occludens toxin (Zot); Region: Zot; cl17485 696748002747 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 696748002748 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 696748002749 ATP binding site [chemical binding]; other site 696748002750 Mg++ binding site [ion binding]; other site 696748002751 motif III; other site 696748002752 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 696748002753 nucleotide binding region [chemical binding]; other site 696748002754 ATP-binding site [chemical binding]; other site 696748002755 Flp/Fap pilin component; Region: Flp_Fap; cl01585 696748002756 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 696748002757 SAF domain; Region: SAF; pfam08666 696748002758 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 696748002759 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 696748002760 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 696748002761 Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963 696748002762 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 696748002763 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 696748002764 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 696748002765 ATP binding site [chemical binding]; other site 696748002766 Walker A motif; other site 696748002767 hexamer interface [polypeptide binding]; other site 696748002768 Walker B motif; other site 696748002769 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 696748002770 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 696748002771 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 696748002772 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 696748002773 Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010 696748002774 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 696748002775 TPR motif; other site 696748002776 binding surface 696748002777 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 696748002778 TadE-like protein; Region: TadE; pfam07811 696748002779 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 696748002780 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 696748002781 Recombination protein O N terminal; Region: RecO_N; pfam11967 696748002782 Recombination protein O C terminal; Region: RecO_C; pfam02565 696748002783 GTPase Era; Reviewed; Region: era; PRK00089 696748002784 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 696748002785 G1 box; other site 696748002786 GTP/Mg2+ binding site [chemical binding]; other site 696748002787 Switch I region; other site 696748002788 G2 box; other site 696748002789 Switch II region; other site 696748002790 G3 box; other site 696748002791 G4 box; other site 696748002792 G5 box; other site 696748002793 KH domain; Region: KH_2; pfam07650 696748002794 ribonuclease III; Reviewed; Region: rnc; PRK00102 696748002795 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 696748002796 dimerization interface [polypeptide binding]; other site 696748002797 active site 696748002798 metal binding site [ion binding]; metal-binding site 696748002799 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 696748002800 dsRNA binding site [nucleotide binding]; other site 696748002801 signal peptidase I; Provisional; Region: PRK10861 696748002802 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 696748002803 Catalytic site [active] 696748002804 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 696748002805 GTP-binding protein LepA; Provisional; Region: PRK05433 696748002806 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 696748002807 G1 box; other site 696748002808 putative GEF interaction site [polypeptide binding]; other site 696748002809 GTP/Mg2+ binding site [chemical binding]; other site 696748002810 Switch I region; other site 696748002811 G2 box; other site 696748002812 G3 box; other site 696748002813 Switch II region; other site 696748002814 G4 box; other site 696748002815 G5 box; other site 696748002816 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 696748002817 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 696748002818 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 696748002819 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 696748002820 thiamine phosphate binding site [chemical binding]; other site 696748002821 active site 696748002822 pyrophosphate binding site [ion binding]; other site 696748002823 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 696748002824 dimer interface [polypeptide binding]; other site 696748002825 substrate binding site [chemical binding]; other site 696748002826 ATP binding site [chemical binding]; other site 696748002827 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 696748002828 substrate binding site [chemical binding]; other site 696748002829 multimerization interface [polypeptide binding]; other site 696748002830 ATP binding site [chemical binding]; other site 696748002831 Triacylglycerol lipase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: Triacylglycerol_lipase_like; cd01847 696748002832 active site 696748002833 oxyanion hole [active] 696748002834 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 696748002835 catalytic triad [active] 696748002836 Autotransporter beta-domain; Region: Autotransporter; cl17461 696748002837 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 696748002838 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 696748002839 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 696748002840 Protein of unknown function (DUF1007); Region: DUF1007; pfam06226 696748002841 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 696748002842 5S rRNA interface [nucleotide binding]; other site 696748002843 CTC domain interface [polypeptide binding]; other site 696748002844 L16 interface [polypeptide binding]; other site 696748002845 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 696748002846 Malic enzyme, N-terminal domain; Region: malic; pfam00390 696748002847 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 696748002848 putative NAD(P) binding site [chemical binding]; other site 696748002849 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 696748002850 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 696748002851 transmembrane helices; other site 696748002852 holo-ACP synthase CitX; Region: citrate_citX; TIGR03124 696748002853 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 696748002854 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 696748002855 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 696748002856 citrate lyase subunit gamma; Provisional; Region: PRK13253 696748002857 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 696748002858 FAD binding site [chemical binding]; other site 696748002859 Uncharacterized conserved protein [Function unknown]; Region: COG1434 696748002860 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 696748002861 putative active site [active] 696748002862 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 696748002863 ATP-grasp domain; Region: ATP-grasp_4; cl17255 696748002864 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 696748002865 dimer interface [polypeptide binding]; other site 696748002866 FMN binding site [chemical binding]; other site 696748002867 NADPH bind site [chemical binding]; other site 696748002868 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 696748002869 Transglycosylase; Region: Transgly; cl17702 696748002870 Trp operon repressor; Provisional; Region: PRK01381 696748002871 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 696748002872 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 696748002873 DNA polymerase I; Provisional; Region: PRK05755 696748002874 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 696748002875 active site 696748002876 metal binding site 1 [ion binding]; metal-binding site 696748002877 putative 5' ssDNA interaction site; other site 696748002878 metal binding site 3; metal-binding site 696748002879 metal binding site 2 [ion binding]; metal-binding site 696748002880 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 696748002881 putative DNA binding site [nucleotide binding]; other site 696748002882 putative metal binding site [ion binding]; other site 696748002883 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 696748002884 active site 696748002885 catalytic site [active] 696748002886 substrate binding site [chemical binding]; other site 696748002887 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 696748002888 active site 696748002889 DNA binding site [nucleotide binding] 696748002890 catalytic site [active] 696748002891 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 696748002892 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 696748002893 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 696748002894 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 696748002895 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 696748002896 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 696748002897 dimer interface [polypeptide binding]; other site 696748002898 ssDNA binding site [nucleotide binding]; other site 696748002899 tetramer (dimer of dimers) interface [polypeptide binding]; other site 696748002900 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 696748002901 dimerization interface [polypeptide binding]; other site 696748002902 putative DNA binding site [nucleotide binding]; other site 696748002903 putative Zn2+ binding site [ion binding]; other site 696748002904 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 696748002905 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 696748002906 catalytic residues [active] 696748002907 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 696748002908 Serine hydrolase (FSH1); Region: FSH1; pfam03959 696748002909 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 696748002910 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696748002911 putative substrate translocation pore; other site 696748002912 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 696748002913 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3676 696748002914 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3676 696748002915 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria and archaea; Region: GIY-YIG_unchar_2; cd10447 696748002916 GIY-YIG motif/motif A; other site 696748002917 putative active site [active] 696748002918 putative metal binding site [ion binding]; other site 696748002919 Transcriptional regulator [Transcription]; Region: LysR; COG0583 696748002920 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 696748002921 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 696748002922 putative effector binding pocket; other site 696748002923 dimerization interface [polypeptide binding]; other site 696748002924 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 696748002925 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 696748002926 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268 696748002927 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 696748002928 putative NAD(P) binding site [chemical binding]; other site 696748002929 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 696748002930 Archaeal ATPase; Region: Arch_ATPase; pfam01637 696748002931 Walker A motif; other site 696748002932 ATP binding site [chemical binding]; other site 696748002933 Walker B motif; other site 696748002934 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 696748002935 Transcriptional regulator [Transcription]; Region: LysR; COG0583 696748002936 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 696748002937 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 696748002938 dimerization interface [polypeptide binding]; other site 696748002939 putative effector binding pocket; other site 696748002940 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 696748002941 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 696748002942 FMN binding site [chemical binding]; other site 696748002943 substrate binding site [chemical binding]; other site 696748002944 putative catalytic residue [active] 696748002945 Choline-glycine betaine transporter [Cell envelope biogenesis, outer membrane]; Region: BetT; COG1292 696748002946 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696748002947 Major Facilitator Superfamily; Region: MFS_1; pfam07690 696748002948 putative substrate translocation pore; other site 696748002949 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 696748002950 Sulfatase; Region: Sulfatase; pfam00884 696748002951 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 696748002952 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 696748002953 MOSC domain; Region: MOSC; pfam03473 696748002954 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 696748002955 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 696748002956 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 696748002957 substrate binding pocket [chemical binding]; other site 696748002958 chain length determination region; other site 696748002959 substrate-Mg2+ binding site; other site 696748002960 catalytic residues [active] 696748002961 aspartate-rich region 1; other site 696748002962 active site lid residues [active] 696748002963 aspartate-rich region 2; other site 696748002964 Protein of unknown function, DUF486; Region: DUF486; cl01236 696748002965 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 696748002966 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 696748002967 dimer interface [polypeptide binding]; other site 696748002968 putative anticodon binding site; other site 696748002969 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 696748002970 motif 1; other site 696748002971 active site 696748002972 motif 2; other site 696748002973 motif 3; other site 696748002974 ribonuclease G; Provisional; Region: PRK11712 696748002975 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 696748002976 homodimer interface [polypeptide binding]; other site 696748002977 oligonucleotide binding site [chemical binding]; other site 696748002978 RNB domain; Region: RNB; pfam00773 696748002979 uncharacterized domain; Region: TIGR00702 696748002980 YcaO-like family; Region: YcaO; pfam02624 696748002981 Restriction endonuclease [Defense mechanisms]; Region: COG3587 696748002982 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 696748002983 ATP binding site [chemical binding]; other site 696748002984 putative Mg++ binding site [ion binding]; other site 696748002985 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 696748002986 DNA methylase; Region: N6_N4_Mtase; cl17433 696748002987 DNA methylase; Region: N6_N4_Mtase; pfam01555 696748002988 DNA methylase; Region: N6_N4_Mtase; cl17433 696748002989 Methyltransferase domain; Region: Methyltransf_23; pfam13489 696748002990 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 696748002991 S-adenosylmethionine binding site [chemical binding]; other site 696748002992 murein transglycosylase A; Provisional; Region: mltA; PRK11162 696748002993 MltA specific insert domain; Region: MltA; smart00925 696748002994 3D domain; Region: 3D; pfam06725 696748002995 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 696748002996 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 696748002997 generic binding surface II; other site 696748002998 generic binding surface I; other site 696748002999 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 696748003000 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 696748003001 trimer interface [polypeptide binding]; other site 696748003002 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 696748003003 trimer interface [polypeptide binding]; other site 696748003004 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 696748003005 trimer interface [polypeptide binding]; other site 696748003006 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 696748003007 trimer interface [polypeptide binding]; other site 696748003008 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 696748003009 trimer interface [polypeptide binding]; other site 696748003010 Haemagglutinin; Region: HIM; pfam05662 696748003011 YadA-like C-terminal region; Region: YadA; pfam03895 696748003012 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 696748003013 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SapD; COG4170 696748003014 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 696748003015 Walker A/P-loop; other site 696748003016 ATP binding site [chemical binding]; other site 696748003017 Q-loop/lid; other site 696748003018 ABC transporter signature motif; other site 696748003019 Walker B; other site 696748003020 D-loop; other site 696748003021 H-loop/switch region; other site 696748003022 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 696748003023 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SapC; COG4171 696748003024 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 696748003025 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 696748003026 putative PBP binding loops; other site 696748003027 dimer interface [polypeptide binding]; other site 696748003028 ABC-ATPase subunit interface; other site 696748003029 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SapB; COG4168 696748003030 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 696748003031 dimer interface [polypeptide binding]; other site 696748003032 conserved gate region; other site 696748003033 putative PBP binding loops; other site 696748003034 ABC-ATPase subunit interface; other site 696748003035 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 696748003036 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 696748003037 peptide binding site [polypeptide binding]; other site 696748003038 Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283 696748003039 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 696748003040 Walker A motif; other site 696748003041 ATP binding site [chemical binding]; other site 696748003042 Walker B motif; other site 696748003043 arginine finger; other site 696748003044 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 696748003045 dimer interface [polypeptide binding]; other site 696748003046 active site 696748003047 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 696748003048 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 696748003049 ligand binding site [chemical binding]; other site 696748003050 calcium binding site [ion binding]; other site 696748003051 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 696748003052 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 696748003053 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 696748003054 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 696748003055 L-lactate permease; Region: Lactate_perm; cl00701 696748003056 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 696748003057 Cysteine-rich domain; Region: CCG; pfam02754 696748003058 Cysteine-rich domain; Region: CCG; pfam02754 696748003059 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 696748003060 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 696748003061 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 696748003062 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 696748003063 Uncharacterized conserved protein [Function unknown]; Region: COG1556 696748003064 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 696748003065 putative active site [active] 696748003066 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 696748003067 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 696748003068 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 696748003069 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 696748003070 DNA binding site [nucleotide binding] 696748003071 domain linker motif; other site 696748003072 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 696748003073 dimerization interface [polypeptide binding]; other site 696748003074 ligand binding site [chemical binding]; other site 696748003075 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 696748003076 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 696748003077 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 696748003078 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 696748003079 Mg2+ binding site [ion binding]; other site 696748003080 G-X-G motif; other site 696748003081 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 696748003082 anchoring element; other site 696748003083 dimer interface [polypeptide binding]; other site 696748003084 ATP binding site [chemical binding]; other site 696748003085 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 696748003086 active site 696748003087 putative metal-binding site [ion binding]; other site 696748003088 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 696748003089 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 696748003090 UbiA prenyltransferase family; Region: UbiA; pfam01040 696748003091 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 696748003092 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 696748003093 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 696748003094 adenylosuccinate lyase; Provisional; Region: PRK09285 696748003095 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 696748003096 tetramer interface [polypeptide binding]; other site 696748003097 active site 696748003098 putative lysogenization regulator; Reviewed; Region: PRK00218 696748003099 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 696748003100 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 696748003101 Ligand binding site; other site 696748003102 metal-binding site 696748003103 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 696748003104 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 696748003105 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 696748003106 Walker A/P-loop; other site 696748003107 ATP binding site [chemical binding]; other site 696748003108 Q-loop/lid; other site 696748003109 ABC transporter signature motif; other site 696748003110 Walker B; other site 696748003111 D-loop; other site 696748003112 H-loop/switch region; other site 696748003113 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 696748003114 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 696748003115 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 696748003116 Walker A/P-loop; other site 696748003117 ATP binding site [chemical binding]; other site 696748003118 Q-loop/lid; other site 696748003119 ABC transporter signature motif; other site 696748003120 Walker B; other site 696748003121 D-loop; other site 696748003122 H-loop/switch region; other site 696748003123 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 696748003124 Family of unknown function (DUF490); Region: DUF490; pfam04357 696748003125 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 696748003126 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 696748003127 Surface antigen; Region: Bac_surface_Ag; pfam01103 696748003128 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 696748003129 NodB motif; other site 696748003130 putative active site [active] 696748003131 putative catalytic site [active] 696748003132 Zn binding site [ion binding]; other site 696748003133 AmiB activator; Provisional; Region: PRK11637 696748003134 Peptidase family M23; Region: Peptidase_M23; pfam01551 696748003135 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 696748003136 catalytic core [active] 696748003137 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 696748003138 Lysine efflux permease [General function prediction only]; Region: COG1279 696748003139 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 696748003140 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 696748003141 Sugar specificity; other site 696748003142 Pyrimidine base specificity; other site 696748003143 ATP-binding site [chemical binding]; other site 696748003144 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 696748003145 trimer interface [polypeptide binding]; other site 696748003146 active site 696748003147 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 696748003148 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 696748003149 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 696748003150 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 696748003151 ligand binding site [chemical binding]; other site 696748003152 homodimer interface [polypeptide binding]; other site 696748003153 NAD(P) binding site [chemical binding]; other site 696748003154 trimer interface B [polypeptide binding]; other site 696748003155 trimer interface A [polypeptide binding]; other site 696748003156 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 696748003157 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 696748003158 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 696748003159 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 696748003160 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 696748003161 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 696748003162 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_4; pfam14281 696748003163 D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213 696748003164 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 696748003165 active site 696748003166 motif I; other site 696748003167 motif II; other site 696748003168 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 696748003169 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 696748003170 catalytic triad [active] 696748003171 HemN family oxidoreductase; Provisional; Region: PRK05660 696748003172 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 696748003173 FeS/SAM binding site; other site 696748003174 HemN C-terminal domain; Region: HemN_C; pfam06969 696748003175 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 696748003176 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 696748003177 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 696748003178 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 696748003179 dimer interface [polypeptide binding]; other site 696748003180 conserved gate region; other site 696748003181 ABC-ATPase subunit interface; other site 696748003182 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 696748003183 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 696748003184 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 696748003185 dimer interface [polypeptide binding]; other site 696748003186 conserved gate region; other site 696748003187 putative PBP binding loops; other site 696748003188 ABC-ATPase subunit interface; other site 696748003189 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 696748003190 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 696748003191 Walker A/P-loop; other site 696748003192 ATP binding site [chemical binding]; other site 696748003193 Q-loop/lid; other site 696748003194 ABC transporter signature motif; other site 696748003195 Walker B; other site 696748003196 D-loop; other site 696748003197 H-loop/switch region; other site 696748003198 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 696748003199 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 696748003200 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 696748003201 Walker A/P-loop; other site 696748003202 ATP binding site [chemical binding]; other site 696748003203 Q-loop/lid; other site 696748003204 ABC transporter signature motif; other site 696748003205 Walker B; other site 696748003206 D-loop; other site 696748003207 H-loop/switch region; other site 696748003208 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 696748003209 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 696748003210 L-aspartate oxidase; Provisional; Region: PRK06175 696748003211 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 696748003212 substrate binding site [chemical binding]; other site 696748003213 THF binding site; other site 696748003214 zinc-binding site [ion binding]; other site 696748003215 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 696748003216 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 696748003217 peptide binding site [polypeptide binding]; other site 696748003218 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 696748003219 serine transporter; Region: stp; TIGR00814 696748003220 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 696748003221 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 696748003222 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 696748003223 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 696748003224 Uncharacterized conserved protein [Function unknown]; Region: COG4121 696748003225 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 696748003226 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 696748003227 active site 696748003228 ribulose/triose binding site [chemical binding]; other site 696748003229 phosphate binding site [ion binding]; other site 696748003230 substrate (anthranilate) binding pocket [chemical binding]; other site 696748003231 product (indole) binding pocket [chemical binding]; other site 696748003232 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 696748003233 active site 696748003234 mobile mystery protein B; Region: mob_myst_B; TIGR02613 696748003235 Fic/DOC family; Region: Fic; pfam02661 696748003236 tRNA pseudouridine synthase C; Region: DUF446; pfam04287 696748003237 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 696748003238 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 696748003239 probable active site [active] 696748003240 Uncharacterized protein family (UPF0181); Region: UPF0181; pfam03701 696748003241 Uncharacterized conserved protein [Function unknown]; Region: COG3025 696748003242 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 696748003243 putative active site [active] 696748003244 putative metal binding residues [ion binding]; other site 696748003245 signature motif; other site 696748003246 putative triphosphate binding site [ion binding]; other site 696748003247 YcjX-like family, DUF463; Region: DUF463; pfam04317 696748003248 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 696748003249 SmpB-tmRNA interface; other site 696748003250 seryl-tRNA synthetase; Provisional; Region: PRK05431 696748003251 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 696748003252 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 696748003253 dimer interface [polypeptide binding]; other site 696748003254 active site 696748003255 motif 1; other site 696748003256 motif 2; other site 696748003257 motif 3; other site 696748003258 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; COG3069 696748003259 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 696748003260 active site pocket [active] 696748003261 oxyanion hole [active] 696748003262 catalytic triad [active] 696748003263 active site nucleophile [active] 696748003264 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 696748003265 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 696748003266 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 696748003267 HIGH motif; other site 696748003268 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 696748003269 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 696748003270 active site 696748003271 KMSKS motif; other site 696748003272 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 696748003273 tRNA binding surface [nucleotide binding]; other site 696748003274 Lipopolysaccharide-assembly; Region: LptE; cl01125 696748003275 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 696748003276 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 696748003277 Domain of unknown function (DUF329); Region: DUF329; pfam03884 696748003278 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 696748003279 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 696748003280 CoA-binding site [chemical binding]; other site 696748003281 ATP-binding [chemical binding]; other site 696748003282 type II secretion system protein F; Region: GspF; TIGR02120 696748003283 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 696748003284 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 696748003285 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 696748003286 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 696748003287 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 696748003288 Walker A motif; other site 696748003289 ATP binding site [chemical binding]; other site 696748003290 Walker B motif; other site 696748003291 putative major pilin subunit; Provisional; Region: PRK10574 696748003292 DNA repair protein RadA; Provisional; Region: PRK11823 696748003293 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 696748003294 Walker A motif/ATP binding site; other site 696748003295 ATP binding site [chemical binding]; other site 696748003296 Walker B motif; other site 696748003297 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 696748003298 aminopeptidase B; Provisional; Region: PRK05015 696748003299 Peptidase; Region: DUF3663; pfam12404 696748003300 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 696748003301 interface (dimer of trimers) [polypeptide binding]; other site 696748003302 Substrate-binding/catalytic site; other site 696748003303 Zn-binding sites [ion binding]; other site 696748003304 KpsF/GutQ family protein; Region: kpsF; TIGR00393 696748003305 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 696748003306 putative active site [active] 696748003307 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 696748003308 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 696748003309 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 696748003310 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 696748003311 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 696748003312 homopentamer interface [polypeptide binding]; other site 696748003313 active site 696748003314 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 696748003315 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 696748003316 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 696748003317 dimerization interface [polypeptide binding]; other site 696748003318 active site 696748003319 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 696748003320 Lumazine binding domain; Region: Lum_binding; pfam00677 696748003321 Lumazine binding domain; Region: Lum_binding; pfam00677 696748003322 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 696748003323 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 696748003324 catalytic motif [active] 696748003325 Zn binding site [ion binding]; other site 696748003326 RibD C-terminal domain; Region: RibD_C; cl17279 696748003327 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 696748003328 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 696748003329 Cysteine-rich domain; Region: CCG; pfam02754 696748003330 Cysteine-rich domain; Region: CCG; pfam02754 696748003331 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 696748003332 glycerol-3-phosphate dehydrogenase, anaerobic, B subunit; Region: glycerol3P_GlpB; TIGR03378 696748003333 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 696748003334 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 696748003335 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 696748003336 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 696748003337 active site 696748003338 catalytic site [active] 696748003339 metal binding site [ion binding]; metal-binding site 696748003340 glycerol-3-phosphate transporter; Region: glpT; TIGR00712 696748003341 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696748003342 putative substrate translocation pore; other site 696748003343 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 696748003344 Found in ATP-dependent protease La (LON); Region: LON; smart00464 696748003345 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 696748003346 Walker A motif; other site 696748003347 ATP binding site [chemical binding]; other site 696748003348 Walker B motif; other site 696748003349 arginine finger; other site 696748003350 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 696748003351 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 696748003352 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 696748003353 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 696748003354 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 696748003355 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 696748003356 HD domain; Region: HD_4; pfam13328 696748003357 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 696748003358 synthetase active site [active] 696748003359 NTP binding site [chemical binding]; other site 696748003360 metal binding site [ion binding]; metal-binding site 696748003361 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 696748003362 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 696748003363 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 696748003364 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 696748003365 tRNA; other site 696748003366 putative tRNA binding site [nucleotide binding]; other site 696748003367 putative NADP binding site [chemical binding]; other site 696748003368 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 696748003369 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 696748003370 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 696748003371 GTP-binding protein Der; Reviewed; Region: PRK00093 696748003372 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 696748003373 G1 box; other site 696748003374 GTP/Mg2+ binding site [chemical binding]; other site 696748003375 Switch I region; other site 696748003376 G2 box; other site 696748003377 Switch II region; other site 696748003378 G3 box; other site 696748003379 G4 box; other site 696748003380 G5 box; other site 696748003381 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 696748003382 G1 box; other site 696748003383 GTP/Mg2+ binding site [chemical binding]; other site 696748003384 Switch I region; other site 696748003385 G2 box; other site 696748003386 G3 box; other site 696748003387 Switch II region; other site 696748003388 G4 box; other site 696748003389 G5 box; other site 696748003390 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 696748003391 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 696748003392 putative ribose interaction site [chemical binding]; other site 696748003393 putative ADP binding site [chemical binding]; other site 696748003394 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 696748003395 active site 696748003396 nucleotide binding site [chemical binding]; other site 696748003397 HIGH motif; other site 696748003398 KMSKS motif; other site 696748003399 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 696748003400 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 696748003401 active site 696748003402 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 696748003403 SurA N-terminal domain; Region: SurA_N; pfam09312 696748003404 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 696748003405 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 696748003406 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 696748003407 S-adenosylmethionine binding site [chemical binding]; other site 696748003408 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 696748003409 active site 696748003410 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 696748003411 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 696748003412 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 696748003413 acyl-activating enzyme (AAE) consensus motif; other site 696748003414 putative AMP binding site [chemical binding]; other site 696748003415 putative active site [active] 696748003416 putative CoA binding site [chemical binding]; other site 696748003417 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246 696748003418 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseA; COG3073 696748003419 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 696748003420 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 696748003421 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 696748003422 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 696748003423 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 696748003424 DNA binding residues [nucleotide binding] 696748003425 2-isopropylmalate synthase; Validated; Region: PRK00915 696748003426 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 696748003427 active site 696748003428 catalytic residues [active] 696748003429 metal binding site [ion binding]; metal-binding site 696748003430 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 696748003431 putative hydrolase; Provisional; Region: PRK10976 696748003432 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 696748003433 active site 696748003434 motif I; other site 696748003435 motif II; other site 696748003436 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 696748003437 macrolide transporter subunit MacA; Provisional; Region: PRK11578 696748003438 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 696748003439 HlyD family secretion protein; Region: HlyD_3; pfam13437 696748003440 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 696748003441 Sodium Bile acid symporter family; Region: SBF; pfam01758 696748003442 Predicted secreted acid phosphatase [General function prediction only]; Region: COG2503 696748003443 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 696748003444 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 696748003445 folate binding site [chemical binding]; other site 696748003446 NADP+ binding site [chemical binding]; other site 696748003447 gamma-glutamyl kinase; Provisional; Region: PRK05429 696748003448 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 696748003449 homotetrameric interface [polypeptide binding]; other site 696748003450 putative phosphate binding site [ion binding]; other site 696748003451 putative allosteric binding site; other site 696748003452 nucleotide binding site [chemical binding]; other site 696748003453 PUA domain; Region: PUA; pfam01472 696748003454 hypothetical protein; Provisional; Region: PRK10621 696748003455 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 696748003456 endonuclease III; Provisional; Region: PRK10702 696748003457 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 696748003458 minor groove reading motif; other site 696748003459 helix-hairpin-helix signature motif; other site 696748003460 substrate binding pocket [chemical binding]; other site 696748003461 active site 696748003462 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 696748003463 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 696748003464 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 696748003465 dimer interface [polypeptide binding]; other site 696748003466 active site 696748003467 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 696748003468 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 696748003469 substrate binding site [chemical binding]; other site 696748003470 oxyanion hole (OAH) forming residues; other site 696748003471 trimer interface [polypeptide binding]; other site 696748003472 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 696748003473 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 696748003474 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 696748003475 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 696748003476 Membrane transport protein; Region: Mem_trans; cl09117 696748003477 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 696748003478 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 696748003479 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 696748003480 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 696748003481 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 696748003482 molybdopterin cofactor binding site; other site 696748003483 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 696748003484 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 696748003485 Cytochrome b subunit of formate dehydrogenase [Energy production and conversion]; Region: FdnI; COG2864 696748003486 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 696748003487 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 696748003488 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 696748003489 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 696748003490 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 696748003491 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 696748003492 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117 696748003493 OstA-like protein; Region: OstA; cl00844 696748003494 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 696748003495 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 696748003496 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 696748003497 Walker A/P-loop; other site 696748003498 ATP binding site [chemical binding]; other site 696748003499 Q-loop/lid; other site 696748003500 ABC transporter signature motif; other site 696748003501 Walker B; other site 696748003502 D-loop; other site 696748003503 H-loop/switch region; other site 696748003504 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 696748003505 active site 696748003506 phosphorylation site [posttranslational modification] 696748003507 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 696748003508 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 696748003509 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 696748003510 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 696748003511 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 696748003512 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 696748003513 nudix motif; other site 696748003514 selenophosphate synthetase; Provisional; Region: PRK00943 696748003515 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 696748003516 dimerization interface [polypeptide binding]; other site 696748003517 putative ATP binding site [chemical binding]; other site 696748003518 Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017 696748003519 nucleotide binding site [chemical binding]; other site 696748003520 Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017 696748003521 Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017 696748003522 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 696748003523 active site 696748003524 NAD-dependent deacetylase; Provisional; Region: PRK00481 696748003525 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 696748003526 NAD+ binding site [chemical binding]; other site 696748003527 substrate binding site [chemical binding]; other site 696748003528 Zn binding site [ion binding]; other site 696748003529 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836 696748003530 Mrr N-terminal domain; Region: Mrr_N; pfam14338 696748003531 Restriction endonuclease; Region: Mrr_cat; pfam04471 696748003532 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cd00296 696748003533 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 696748003534 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 696748003535 Walker A motif; other site 696748003536 ATP binding site [chemical binding]; other site 696748003537 Walker B motif; other site 696748003538 arginine finger; other site 696748003539 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 696748003540 Walker A motif; other site 696748003541 ATP binding site [chemical binding]; other site 696748003542 Walker B motif; other site 696748003543 arginine finger; other site 696748003544 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 696748003545 Fic/DOC family; Region: Fic; pfam02661 696748003546 Fic/DOC family; Region: Fic; cl00960 696748003547 WYL domain; Region: WYL; pfam13280 696748003548 peptide chain release factor 2; Provisional; Region: PRK08787 696748003549 This domain is found in peptide chain release factors; Region: PCRF; smart00937 696748003550 RF-1 domain; Region: RF-1; pfam00472 696748003551 Predicted permeases [General function prediction only]; Region: COG0679 696748003552 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 696748003553 substrate binding site [chemical binding]; other site 696748003554 THF binding site; other site 696748003555 zinc-binding site [ion binding]; other site 696748003556 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 696748003557 active site 696748003558 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 696748003559 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 696748003560 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 696748003561 amidase catalytic site [active] 696748003562 Zn binding residues [ion binding]; other site 696748003563 substrate binding site [chemical binding]; other site 696748003564 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 696748003565 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 696748003566 active site 696748003567 ATP-dependent helicase HepA; Validated; Region: PRK04914 696748003568 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 696748003569 ATP binding site [chemical binding]; other site 696748003570 putative Mg++ binding site [ion binding]; other site 696748003571 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 696748003572 nucleotide binding region [chemical binding]; other site 696748003573 ATP-binding site [chemical binding]; other site 696748003574 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK05318 696748003575 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 696748003576 Zn2+ binding site [ion binding]; other site 696748003577 Mg2+ binding site [ion binding]; other site 696748003578 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 696748003579 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 696748003580 TRAM domain; Region: TRAM; pfam01938 696748003581 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 696748003582 S-adenosylmethionine binding site [chemical binding]; other site 696748003583 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 696748003584 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 696748003585 ATP binding site [chemical binding]; other site 696748003586 substrate interface [chemical binding]; other site 696748003587 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 696748003588 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 696748003589 dimer interface [polypeptide binding]; other site 696748003590 putative functional site; other site 696748003591 putative MPT binding site; other site 696748003592 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 696748003593 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 696748003594 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 696748003595 Walker A/P-loop; other site 696748003596 ATP binding site [chemical binding]; other site 696748003597 Q-loop/lid; other site 696748003598 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 696748003599 ABC transporter; Region: ABC_tran_2; pfam12848 696748003600 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 696748003601 hypothetical protein; Provisional; Region: PRK05415 696748003602 Domain of unknown function (DUF697); Region: DUF697; cl12064 696748003603 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_3; pfam13366 696748003604 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 696748003605 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 696748003606 FMN binding site [chemical binding]; other site 696748003607 active site 696748003608 catalytic residues [active] 696748003609 substrate binding site [chemical binding]; other site 696748003610 Predicted membrane protein (DUF2238); Region: DUF2238; cl01464 696748003611 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 696748003612 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 696748003613 putative metal binding site [ion binding]; other site 696748003614 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 696748003615 HSP70 interaction site [polypeptide binding]; other site 696748003616 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 696748003617 ligand binding site [chemical binding]; other site 696748003618 translocation protein TolB; Provisional; Region: tolB; PRK01742 696748003619 TolB amino-terminal domain; Region: TolB_N; pfam04052 696748003620 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 696748003621 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 696748003622 TolA C-terminal; Region: TolA; pfam06519 696748003623 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 696748003624 colicin uptake protein TolR; Provisional; Region: PRK11024 696748003625 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 696748003626 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 696748003627 active site 696748003628 cyd operon protein YbgE; Region: cyd_oper_ybgE; TIGR02112 696748003629 Membrane bound YbgT-like protein; Region: YbgT_YccB; pfam08173 696748003630 cytochrome d oxidase, subunit II (cydB); Region: cydB; TIGR00203 696748003631 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 696748003632 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 696748003633 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 696748003634 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 696748003635 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 696748003636 ring oligomerisation interface [polypeptide binding]; other site 696748003637 ATP/Mg binding site [chemical binding]; other site 696748003638 stacking interactions; other site 696748003639 hinge regions; other site 696748003640 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 696748003641 oligomerisation interface [polypeptide binding]; other site 696748003642 mobile loop; other site 696748003643 roof hairpin; other site 696748003644 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 696748003645 active site 696748003646 8-oxo-dGMP binding site [chemical binding]; other site 696748003647 nudix motif; other site 696748003648 metal binding site [ion binding]; metal-binding site 696748003649 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 696748003650 TPR motif; other site 696748003651 TPR repeat; Region: TPR_11; pfam13414 696748003652 binding surface 696748003653 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 696748003654 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 696748003655 binding surface 696748003656 TPR motif; other site 696748003657 TPR repeat; Region: TPR_11; pfam13414 696748003658 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 696748003659 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 696748003660 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 696748003661 SEC-C motif; Region: SEC-C; pfam02810 696748003662 Protein of unknown function (DUF2547); Region: DUF2547; pfam10818 696748003663 Protein of unknown function (DUF721); Region: DUF721; cl02324 696748003664 NlpE N-terminal domain; Region: NlpE; pfam04170 696748003665 BolA-like protein; Region: BolA; cl00386 696748003666 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 696748003667 Transcriptional regulators [Transcription]; Region: PurR; COG1609 696748003668 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 696748003669 DNA binding site [nucleotide binding] 696748003670 domain linker motif; other site 696748003671 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 696748003672 putative dimerization interface [polypeptide binding]; other site 696748003673 putative ligand binding site [chemical binding]; other site 696748003674 galactoside permease; Reviewed; Region: lacY; PRK09528 696748003675 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696748003676 putative substrate translocation pore; other site 696748003677 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 696748003678 Melibiase; Region: Melibiase; pfam02065 696748003679 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 696748003680 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 696748003681 Walker A/P-loop; other site 696748003682 ATP binding site [chemical binding]; other site 696748003683 Q-loop/lid; other site 696748003684 ABC transporter signature motif; other site 696748003685 Walker B; other site 696748003686 D-loop; other site 696748003687 H-loop/switch region; other site 696748003688 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 696748003689 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 696748003690 Walker A/P-loop; other site 696748003691 ATP binding site [chemical binding]; other site 696748003692 Q-loop/lid; other site 696748003693 ABC transporter signature motif; other site 696748003694 Walker B; other site 696748003695 D-loop; other site 696748003696 H-loop/switch region; other site 696748003697 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 696748003698 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 696748003699 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 696748003700 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 696748003701 dimer interface [polypeptide binding]; other site 696748003702 conserved gate region; other site 696748003703 ABC-ATPase subunit interface; other site 696748003704 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 696748003705 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 696748003706 dimer interface [polypeptide binding]; other site 696748003707 conserved gate region; other site 696748003708 putative PBP binding loops; other site 696748003709 ABC-ATPase subunit interface; other site 696748003710 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 696748003711 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 696748003712 Walker A motif; other site 696748003713 ATP binding site [chemical binding]; other site 696748003714 Walker B motif; other site 696748003715 arginine finger; other site 696748003716 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 696748003717 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 696748003718 RuvA N terminal domain; Region: RuvA_N; pfam01330 696748003719 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 696748003720 helix-hairpin-helix signature motif; other site 696748003721 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 696748003722 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 696748003723 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 696748003724 dimer interface [polypeptide binding]; other site 696748003725 conserved gate region; other site 696748003726 putative PBP binding loops; other site 696748003727 ABC-ATPase subunit interface; other site 696748003728 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 696748003729 dimer interface [polypeptide binding]; other site 696748003730 conserved gate region; other site 696748003731 putative PBP binding loops; other site 696748003732 ABC-ATPase subunit interface; other site 696748003733 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 696748003734 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 696748003735 Walker A/P-loop; other site 696748003736 ATP binding site [chemical binding]; other site 696748003737 Q-loop/lid; other site 696748003738 ABC transporter signature motif; other site 696748003739 Walker B; other site 696748003740 D-loop; other site 696748003741 H-loop/switch region; other site 696748003742 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 696748003743 non-specific DNA binding site [nucleotide binding]; other site 696748003744 salt bridge; other site 696748003745 sequence-specific DNA binding site [nucleotide binding]; other site 696748003746 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 696748003747 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 696748003748 Part of AAA domain; Region: AAA_19; pfam13245 696748003749 Family description; Region: UvrD_C_2; pfam13538 696748003750 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 696748003751 active site 696748003752 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 696748003753 S-adenosylmethionine synthetase; Validated; Region: PRK05250 696748003754 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 696748003755 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 696748003756 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; COG2040 696748003757 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 696748003758 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 696748003759 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 696748003760 acetylornithine deacetylase; Provisional; Region: PRK05111 696748003761 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 696748003762 metal binding site [ion binding]; metal-binding site 696748003763 putative dimer interface [polypeptide binding]; other site 696748003764 Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047 696748003765 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 696748003766 Clp amino terminal domain; Region: Clp_N; pfam02861 696748003767 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 696748003768 Walker A motif; other site 696748003769 ATP binding site [chemical binding]; other site 696748003770 Walker B motif; other site 696748003771 arginine finger; other site 696748003772 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 696748003773 Walker A motif; other site 696748003774 ATP binding site [chemical binding]; other site 696748003775 Walker B motif; other site 696748003776 arginine finger; other site 696748003777 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 696748003778 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 696748003779 arsenical-resistance protein; Region: acr3; TIGR00832 696748003780 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 696748003781 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 696748003782 Sulfate transporter family; Region: Sulfate_transp; pfam00916 696748003783 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 696748003784 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 696748003785 ArsC family; Region: ArsC; pfam03960 696748003786 catalytic residues [active] 696748003787 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 696748003788 putative DNA binding site [nucleotide binding]; other site 696748003789 dimerization interface [polypeptide binding]; other site 696748003790 putative Zn2+ binding site [ion binding]; other site 696748003791 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 696748003792 Aspartase; Region: Aspartase; cd01357 696748003793 active sites [active] 696748003794 tetramer interface [polypeptide binding]; other site 696748003795 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 696748003796 regulatory protein UhpC; Provisional; Region: PRK11663 696748003797 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696748003798 putative substrate translocation pore; other site 696748003799 sensory histidine kinase UhpB; Provisional; Region: PRK11644 696748003800 MASE1; Region: MASE1; pfam05231 696748003801 Histidine kinase; Region: HisKA_3; pfam07730 696748003802 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 696748003803 ATP binding site [chemical binding]; other site 696748003804 Mg2+ binding site [ion binding]; other site 696748003805 G-X-G motif; other site 696748003806 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 696748003807 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 696748003808 active site 696748003809 phosphorylation site [posttranslational modification] 696748003810 intermolecular recognition site; other site 696748003811 dimerization interface [polypeptide binding]; other site 696748003812 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 696748003813 DNA binding residues [nucleotide binding] 696748003814 dimerization interface [polypeptide binding]; other site 696748003815 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 696748003816 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696748003817 putative substrate translocation pore; other site 696748003818 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 696748003819 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 696748003820 dimerization interface [polypeptide binding]; other site 696748003821 putative ATP binding site [chemical binding]; other site 696748003822 Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564 696748003823 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 696748003824 active site 696748003825 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 696748003826 Ligand Binding Site [chemical binding]; other site 696748003827 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 696748003828 active site 696748003829 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 696748003830 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 696748003831 FeS/SAM binding site; other site 696748003832 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 696748003833 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696748003834 putative substrate translocation pore; other site 696748003835 multifunctional aminopeptidase A; Provisional; Region: PRK00913 696748003836 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 696748003837 interface (dimer of trimers) [polypeptide binding]; other site 696748003838 Substrate-binding/catalytic site; other site 696748003839 Zn-binding sites [ion binding]; other site 696748003840 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 696748003841 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 696748003842 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 696748003843 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 696748003844 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 696748003845 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 696748003846 active site 696748003847 phosphorylation site [posttranslational modification] 696748003848 intermolecular recognition site; other site 696748003849 dimerization interface [polypeptide binding]; other site 696748003850 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 696748003851 Walker A motif; other site 696748003852 ATP binding site [chemical binding]; other site 696748003853 Walker B motif; other site 696748003854 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 696748003855 Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms]; Region: COG4192 696748003856 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 696748003857 dimer interface [polypeptide binding]; other site 696748003858 phosphorylation site [posttranslational modification] 696748003859 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 696748003860 ATP binding site [chemical binding]; other site 696748003861 Mg2+ binding site [ion binding]; other site 696748003862 G-X-G motif; other site 696748003863 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 696748003864 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 696748003865 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696748003866 putative substrate translocation pore; other site 696748003867 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 696748003868 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 696748003869 putative active site [active] 696748003870 putative PHP Thumb interface [polypeptide binding]; other site 696748003871 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 696748003872 generic binding surface II; other site 696748003873 generic binding surface I; other site 696748003874 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 696748003875 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696748003876 ATP-grasp domain; Region: ATP-grasp; pfam02222 696748003877 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 696748003878 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 696748003879 putative acyl-acceptor binding pocket; other site 696748003880 LexA repressor; Validated; Region: PRK00215 696748003881 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 696748003882 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 696748003883 Catalytic site [active] 696748003884 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 696748003885 putative DNA-binding cleft [nucleotide binding]; other site 696748003886 putative DNA clevage site; other site 696748003887 molecular lever; other site 696748003888 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 696748003889 beta-hexosaminidase; Provisional; Region: PRK05337 696748003890 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 696748003891 23S rRNA methyluridine methyltransferase; Reviewed; Region: rumB; PRK03522 696748003892 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 696748003893 S-adenosylmethionine binding site [chemical binding]; other site 696748003894 enolase; Provisional; Region: eno; PRK00077 696748003895 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 696748003896 dimer interface [polypeptide binding]; other site 696748003897 metal binding site [ion binding]; metal-binding site 696748003898 substrate binding pocket [chemical binding]; other site 696748003899 Uncharacterized protein conserved in bacteria (DUF2251); Region: DUF2251; pfam10008 696748003900 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 696748003901 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 696748003902 ATP binding site [chemical binding]; other site 696748003903 putative Mg++ binding site [ion binding]; other site 696748003904 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 696748003905 nucleotide binding region [chemical binding]; other site 696748003906 ATP-binding site [chemical binding]; other site 696748003907 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 696748003908 HRDC domain; Region: HRDC; pfam00570 696748003909 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 696748003910 putative iron binding site [ion binding]; other site 696748003911 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 696748003912 metal binding triad [ion binding]; metal-binding site 696748003913 UGMP family protein; Validated; Region: PRK09604 696748003914 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 696748003915 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 696748003916 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 696748003917 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 696748003918 RNA binding surface [nucleotide binding]; other site 696748003919 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 696748003920 active site 696748003921 YwiC-like protein; Region: YwiC; pfam14256 696748003922 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 696748003923 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 696748003924 active site 696748003925 ADP/pyrophosphate binding site [chemical binding]; other site 696748003926 dimerization interface [polypeptide binding]; other site 696748003927 allosteric effector site; other site 696748003928 fructose-1,6-bisphosphate binding site; other site 696748003929 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 696748003930 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 696748003931 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 696748003932 catalytic residue [active] 696748003933 Staphylococcal nuclease homologues; Region: SNc; smart00318 696748003934 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 696748003935 Catalytic site; other site 696748003936 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 696748003937 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 696748003938 amino acid carrier protein; Region: agcS; TIGR00835 696748003939 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 696748003940 Domain of unknown function DUF20; Region: UPF0118; pfam01594 696748003941 Cytochrome b562; Region: Cytochrom_B562; cl01546 696748003942 putative protease; Provisional; Region: PRK15452 696748003943 Peptidase family U32; Region: Peptidase_U32; pfam01136 696748003944 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 696748003945 O-Antigen ligase; Region: Wzy_C; pfam04932 696748003946 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 696748003947 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 696748003948 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 696748003949 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 696748003950 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 696748003951 active site 696748003952 (T/H)XGH motif; other site 696748003953 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 696748003954 catalytic site [active] 696748003955 putative active site [active] 696748003956 putative substrate binding site [chemical binding]; other site 696748003957 dimer interface [polypeptide binding]; other site 696748003958 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 696748003959 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 696748003960 active site 696748003961 metal binding site [ion binding]; metal-binding site 696748003962 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 696748003963 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 696748003964 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 696748003965 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 696748003966 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 696748003967 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 696748003968 FMN binding site [chemical binding]; other site 696748003969 active site 696748003970 catalytic residues [active] 696748003971 substrate binding site [chemical binding]; other site 696748003972 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 696748003973 catalytic core [active] 696748003974 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 696748003975 pyruvate kinase; Provisional; Region: PRK05826 696748003976 domain interfaces; other site 696748003977 active site 696748003978 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 696748003979 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 696748003980 putative active site [active] 696748003981 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 696748003982 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 696748003983 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 696748003984 chorismate mutase domain of T-protein; Region: CM_T; TIGR01799 696748003985 prephenate dehydrogenase; Provisional; Region: PRK06444 696748003986 putative transposase OrfB; Reviewed; Region: PHA02517 696748003987 HTH-like domain; Region: HTH_21; pfam13276 696748003988 Integrase core domain; Region: rve; pfam00665 696748003989 Integrase core domain; Region: rve_2; pfam13333 696748003990 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 696748003991 Helix-turn-helix domain; Region: HTH_28; pfam13518 696748003992 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 696748003993 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 696748003994 TPP-binding site; other site 696748003995 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 696748003996 PYR/PP interface [polypeptide binding]; other site 696748003997 dimer interface [polypeptide binding]; other site 696748003998 TPP binding site [chemical binding]; other site 696748003999 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 696748004000 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 696748004001 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 696748004002 active site 696748004003 dimerization interface [polypeptide binding]; other site 696748004004 putative methyltransferase; Provisional; Region: PRK10864 696748004005 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 696748004006 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 696748004007 LysE type translocator; Region: LysE; cl00565 696748004008 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 696748004009 tetramer interfaces [polypeptide binding]; other site 696748004010 binuclear metal-binding site [ion binding]; other site 696748004011 thiamine monophosphate kinase; Provisional; Region: PRK05731 696748004012 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 696748004013 ATP binding site [chemical binding]; other site 696748004014 dimerization interface [polypeptide binding]; other site 696748004015 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 696748004016 putative RNA binding site [nucleotide binding]; other site 696748004017 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 696748004018 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 696748004019 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 696748004020 Competence protein A; Region: Competence_A; pfam11104 696748004021 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 696748004022 Transglycosylase; Region: Transgly; pfam00912 696748004023 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 696748004024 shikimate kinase; Reviewed; Region: aroK; PRK00131 696748004025 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 696748004026 ADP binding site [chemical binding]; other site 696748004027 magnesium binding site [ion binding]; other site 696748004028 putative shikimate binding site; other site 696748004029 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 696748004030 active site 696748004031 dimer interface [polypeptide binding]; other site 696748004032 metal binding site [ion binding]; metal-binding site 696748004033 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 696748004034 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 696748004035 Na2 binding site [ion binding]; other site 696748004036 putative substrate binding site 1 [chemical binding]; other site 696748004037 Na binding site 1 [ion binding]; other site 696748004038 putative substrate binding site 2 [chemical binding]; other site 696748004039 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 696748004040 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 696748004041 active site 696748004042 dimer interface [polypeptide binding]; other site 696748004043 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 696748004044 dimer interface [polypeptide binding]; other site 696748004045 active site 696748004046 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 696748004047 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 696748004048 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 696748004049 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 696748004050 shikimate binding site; other site 696748004051 NAD(P) binding site [chemical binding]; other site 696748004052 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 696748004053 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 696748004054 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 696748004055 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 696748004056 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 696748004057 recombination regulator RecX; Reviewed; Region: recX; PRK00117 696748004058 recombinase A; Provisional; Region: recA; PRK09354 696748004059 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 696748004060 hexamer interface [polypeptide binding]; other site 696748004061 Walker A motif; other site 696748004062 ATP binding site [chemical binding]; other site 696748004063 Walker B motif; other site 696748004064 hypothetical protein; Provisional; Region: PRK07101 696748004065 para-aminobenzoate synthase component I; Validated; Region: PRK07093 696748004066 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 696748004067 RmuC family; Region: RmuC; pfam02646 696748004068 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 696748004069 Glutamine amidotransferase class-I; Region: GATase; pfam00117 696748004070 glutamine binding [chemical binding]; other site 696748004071 catalytic triad [active] 696748004072 Domain of unknown function DUF302; Region: DUF302; cl01364 696748004073 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 696748004074 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 696748004075 putative acyl-acceptor binding pocket; other site 696748004076 electron transport complex RsxE subunit; Provisional; Region: PRK12405 696748004077 electron transport complex protein RnfG; Validated; Region: PRK01908 696748004078 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 696748004079 Predicted membrane protein [Function unknown]; Region: COG2860 696748004080 UPF0126 domain; Region: UPF0126; pfam03458 696748004081 UPF0126 domain; Region: UPF0126; pfam03458 696748004082 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 696748004083 SLBB domain; Region: SLBB; pfam10531 696748004084 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 696748004085 ferredoxin; Provisional; Region: PRK08764 696748004086 Putative Fe-S cluster; Region: FeS; pfam04060 696748004087 4Fe-4S binding domain; Region: Fer4; pfam00037 696748004088 electron transport complex protein RsxA; Provisional; Region: PRK05151 696748004089 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 696748004090 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 696748004091 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 696748004092 putative active site [active] 696748004093 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 696748004094 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 696748004095 Walker A/P-loop; other site 696748004096 ATP binding site [chemical binding]; other site 696748004097 Q-loop/lid; other site 696748004098 ABC transporter signature motif; other site 696748004099 Walker B; other site 696748004100 D-loop; other site 696748004101 H-loop/switch region; other site 696748004102 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 696748004103 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 696748004104 HlyD family secretion protein; Region: HlyD_3; pfam13437 696748004105 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: RNR_activ_nrdG3; TIGR02826 696748004106 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 696748004107 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08271 696748004108 Class III ribonucleotide reductase; Region: RNR_III; cd01675 696748004109 effector binding site; other site 696748004110 active site 696748004111 Zn binding site [ion binding]; other site 696748004112 glycine loop; other site 696748004113 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 696748004114 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 696748004115 motif II; other site 696748004116 recombination associated protein; Reviewed; Region: rdgC; PRK00321 696748004117 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 696748004118 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 696748004119 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 696748004120 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696748004121 putative substrate translocation pore; other site 696748004122 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 696748004123 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 696748004124 putative active site [active] 696748004125 (T/H)XGH motif; other site 696748004126 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 696748004127 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 696748004128 Ligand Binding Site [chemical binding]; other site 696748004129 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2991 696748004130 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 696748004131 ApbE family; Region: ApbE; pfam02424 696748004132 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 696748004133 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 696748004134 FAD binding pocket [chemical binding]; other site 696748004135 FAD binding motif [chemical binding]; other site 696748004136 phosphate binding motif [ion binding]; other site 696748004137 beta-alpha-beta structure motif; other site 696748004138 NAD binding pocket [chemical binding]; other site 696748004139 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830 696748004140 Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292 696748004141 Na(+)-translocating NADH-quinone reductase subunit C; Provisional; Region: PRK05346 696748004142 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 696748004143 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349 696748004144 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 696748004145 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 696748004146 E3 interaction surface; other site 696748004147 lipoyl attachment site [posttranslational modification]; other site 696748004148 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 696748004149 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 696748004150 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 696748004151 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 696748004152 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 696748004153 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 696748004154 active site 696748004155 purine riboside binding site [chemical binding]; other site 696748004156 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09102 696748004157 Class I ribonucleotide reductase; Region: RNR_I; cd01679 696748004158 active site 696748004159 dimer interface [polypeptide binding]; other site 696748004160 catalytic residues [active] 696748004161 effector binding site; other site 696748004162 R2 peptide binding site; other site 696748004163 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 696748004164 dimer interface [polypeptide binding]; other site 696748004165 putative radical transfer pathway; other site 696748004166 diiron center [ion binding]; other site 696748004167 tyrosyl radical; other site 696748004168 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 696748004169 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 696748004170 FMN binding site [chemical binding]; other site 696748004171 active site 696748004172 catalytic residues [active] 696748004173 substrate binding site [chemical binding]; other site 696748004174 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 696748004175 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 696748004176 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 696748004177 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 696748004178 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 696748004179 putative active site [active] 696748004180 putative metal-binding site [ion binding]; other site 696748004181 Acylphosphatase; Region: Acylphosphatase; cl00551 696748004182 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 696748004183 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 696748004184 fructuronate transporter; Provisional; Region: PRK10034; cl15264 696748004185 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 696748004186 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 696748004187 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 696748004188 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 696748004189 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 696748004190 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 696748004191 peptide binding site [polypeptide binding]; other site 696748004192 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 696748004193 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 696748004194 substrate binding site [chemical binding]; other site 696748004195 ligand binding site [chemical binding]; other site 696748004196 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 696748004197 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 696748004198 substrate binding site [chemical binding]; other site 696748004199 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 696748004200 active site 696748004201 Uncharacterized integral membrane protein (DUF2301); Region: DUF2301; cl02241 696748004202 CTP synthetase; Validated; Region: pyrG; PRK05380 696748004203 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 696748004204 Catalytic site [active] 696748004205 active site 696748004206 UTP binding site [chemical binding]; other site 696748004207 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 696748004208 active site 696748004209 putative oxyanion hole; other site 696748004210 catalytic triad [active] 696748004211 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 696748004212 active site 696748004213 homotetramer interface [polypeptide binding]; other site 696748004214 homodimer interface [polypeptide binding]; other site 696748004215 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 696748004216 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 696748004217 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 696748004218 substrate binding site [chemical binding]; other site 696748004219 dimerization interface [polypeptide binding]; other site 696748004220 dUMP phosphatase; Provisional; Region: PRK09449 696748004221 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 696748004222 motif II; other site 696748004223 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 696748004224 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 696748004225 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 696748004226 dimerization interface [polypeptide binding]; other site 696748004227 substrate binding pocket [chemical binding]; other site 696748004228 GTPase RsgA; Reviewed; Region: PRK12288 696748004229 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 696748004230 RNA binding site [nucleotide binding]; other site 696748004231 homodimer interface [polypeptide binding]; other site 696748004232 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 696748004233 GTPase/Zn-binding domain interface [polypeptide binding]; other site 696748004234 GTP/Mg2+ binding site [chemical binding]; other site 696748004235 G4 box; other site 696748004236 G5 box; other site 696748004237 G1 box; other site 696748004238 Switch I region; other site 696748004239 G2 box; other site 696748004240 G3 box; other site 696748004241 Switch II region; other site 696748004242 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 696748004243 RNA/DNA hybrid binding site [nucleotide binding]; other site 696748004244 active site 696748004245 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 696748004246 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 696748004247 ABC-ATPase subunit interface; other site 696748004248 dimer interface [polypeptide binding]; other site 696748004249 putative PBP binding regions; other site 696748004250 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 696748004251 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 696748004252 ABC-ATPase subunit interface; other site 696748004253 dimer interface [polypeptide binding]; other site 696748004254 putative PBP binding regions; other site 696748004255 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 696748004256 nucleotide binding site/active site [active] 696748004257 HIT family signature motif; other site 696748004258 catalytic residue [active] 696748004259 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 696748004260 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 696748004261 putative dimer interface [polypeptide binding]; other site 696748004262 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 696748004263 active site 696748004264 substrate binding site [chemical binding]; other site 696748004265 ATP binding site [chemical binding]; other site 696748004266 Phosphotransferase enzyme family; Region: APH; pfam01636 696748004267 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 696748004268 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 696748004269 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 696748004270 Peptidase M15; Region: Peptidase_M15_3; cl01194 696748004271 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 696748004272 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 696748004273 carboxy-terminal protease; Provisional; Region: PRK11186 696748004274 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 696748004275 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 696748004276 protein binding site [polypeptide binding]; other site 696748004277 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 696748004278 Catalytic dyad [active] 696748004279 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 696748004280 ProP expression regulator; Provisional; Region: PRK04950 696748004281 ProQ/FINO family; Region: ProQ; pfam04352 696748004282 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 696748004283 DNA-binding site [nucleotide binding]; DNA binding site 696748004284 RNA-binding motif; other site 696748004285 biotin synthase; Region: bioB; TIGR00433 696748004286 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 696748004287 FeS/SAM binding site; other site 696748004288 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 696748004289 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 696748004290 thymidylate synthase; Reviewed; Region: thyA; PRK01827 696748004291 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 696748004292 dimerization interface [polypeptide binding]; other site 696748004293 active site 696748004294 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 696748004295 IHF dimer interface [polypeptide binding]; other site 696748004296 IHF - DNA interface [nucleotide binding]; other site 696748004297 Protein of unknown function (DUF416); Region: DUF416; cl01166 696748004298 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 696748004299 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 696748004300 substrate binding site [chemical binding]; other site 696748004301 active site 696748004302 hypothetical protein; Reviewed; Region: PRK01736 696748004303 Cell division protein ZapA; Region: ZapA; cl01146 696748004304 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 696748004305 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 696748004306 Transcriptional regulator [Transcription]; Region: IclR; COG1414 696748004307 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 696748004308 putative DNA binding site [nucleotide binding]; other site 696748004309 putative Zn2+ binding site [ion binding]; other site 696748004310 Bacterial transcriptional regulator; Region: IclR; pfam01614 696748004311 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 696748004312 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 696748004313 Na binding site [ion binding]; other site 696748004314 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905 696748004315 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 696748004316 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 696748004317 Glutamate binding site [chemical binding]; other site 696748004318 NAD binding site [chemical binding]; other site 696748004319 catalytic residues [active] 696748004320 uracil-xanthine permease; Region: ncs2; TIGR00801 696748004321 Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829 696748004322 haemagglutination activity domain; Region: Haemagg_act; pfam05860 696748004323 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 696748004324 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 696748004325 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 696748004326 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 696748004327 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 696748004328 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 696748004329 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 696748004330 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 696748004331 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 696748004332 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 696748004333 trimer interface [polypeptide binding]; other site 696748004334 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 696748004335 trimer interface [polypeptide binding]; other site 696748004336 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 696748004337 YadA-like C-terminal region; Region: YadA; pfam03895 696748004338 Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301 696748004339 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 696748004340 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 696748004341 cytochrome c nitrite reductase, pentaheme subunit; Region: cyt_nit_nrfB; TIGR03146 696748004342 cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125 696748004343 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 696748004344 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 696748004345 putative ligand binding site [chemical binding]; other site 696748004346 putative NAD binding site [chemical binding]; other site 696748004347 catalytic site [active] 696748004348 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 696748004349 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 696748004350 PYR/PP interface [polypeptide binding]; other site 696748004351 dimer interface [polypeptide binding]; other site 696748004352 TPP binding site [chemical binding]; other site 696748004353 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 696748004354 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 696748004355 TPP-binding site [chemical binding]; other site 696748004356 dimer interface [polypeptide binding]; other site 696748004357 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 696748004358 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 696748004359 dimer interface [polypeptide binding]; other site 696748004360 substrate binding site [chemical binding]; other site 696748004361 metal binding sites [ion binding]; metal-binding site 696748004362 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 696748004363 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 696748004364 ZIP Zinc transporter; Region: Zip; pfam02535 696748004365 Protein of unknown function (DUF805); Region: DUF805; pfam05656 696748004366 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 696748004367 G1 box; other site 696748004368 GTP/Mg2+ binding site [chemical binding]; other site 696748004369 Switch I region; other site 696748004370 G2 box; other site 696748004371 G3 box; other site 696748004372 Switch II region; other site 696748004373 G4 box; other site 696748004374 G5 box; other site 696748004375 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 696748004376 RNase E inhibitor protein; Provisional; Region: PRK11191 696748004377 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 696748004378 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 696748004379 CPxP motif; other site 696748004380 proline dipeptidase; Provisional; Region: PRK13607 696748004381 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 696748004382 active site 696748004383 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 696748004384 EamA-like transporter family; Region: EamA; cl17759 696748004385 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 696748004386 EamA-like transporter family; Region: EamA; pfam00892 696748004387 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 696748004388 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 696748004389 active site 696748004390 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 696748004391 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 696748004392 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 696748004393 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 696748004394 putative NADH binding site [chemical binding]; other site 696748004395 putative active site [active] 696748004396 nudix motif; other site 696748004397 putative metal binding site [ion binding]; other site 696748004398 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 696748004399 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 696748004400 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 696748004401 Ligand binding site; other site 696748004402 oligomer interface; other site 696748004403 thioredoxin reductase; Provisional; Region: PRK10262 696748004404 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 696748004405 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 696748004406 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK11468 696748004407 Dak1 domain; Region: Dak1; pfam02733 696748004408 dihydroxyacetone kinase subunit DhaL; Provisional; Region: PRK10005 696748004409 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 696748004410 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 696748004411 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 696748004412 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 696748004413 active site residue [active] 696748004414 tonB-system energizer ExbB, group 2; Region: exbB2; TIGR02805 696748004415 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 696748004416 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 696748004417 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 696748004418 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 696748004419 hypothetical protein; Validated; Region: PRK00153 696748004420 recombination protein RecR; Reviewed; Region: recR; PRK00076 696748004421 RecR protein; Region: RecR; pfam02132 696748004422 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 696748004423 putative active site [active] 696748004424 putative metal-binding site [ion binding]; other site 696748004425 tetramer interface [polypeptide binding]; other site 696748004426 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 696748004427 putative GSH binding site [chemical binding]; other site 696748004428 catalytic residues [active] 696748004429 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 696748004430 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 696748004431 homodimer interface [polypeptide binding]; other site 696748004432 substrate-cofactor binding pocket; other site 696748004433 catalytic residue [active] 696748004434 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 696748004435 homotrimer interaction site [polypeptide binding]; other site 696748004436 putative active site [active] 696748004437 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 696748004438 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 696748004439 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 696748004440 Walker A/P-loop; other site 696748004441 ATP binding site [chemical binding]; other site 696748004442 Q-loop/lid; other site 696748004443 ABC transporter signature motif; other site 696748004444 Walker B; other site 696748004445 D-loop; other site 696748004446 H-loop/switch region; other site 696748004447 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 696748004448 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 696748004449 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 696748004450 Walker A/P-loop; other site 696748004451 ATP binding site [chemical binding]; other site 696748004452 Q-loop/lid; other site 696748004453 ABC transporter signature motif; other site 696748004454 Walker B; other site 696748004455 D-loop; other site 696748004456 H-loop/switch region; other site 696748004457 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 696748004458 dipeptide transporter; Provisional; Region: PRK10913 696748004459 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 696748004460 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 696748004461 dimer interface [polypeptide binding]; other site 696748004462 conserved gate region; other site 696748004463 putative PBP binding loops; other site 696748004464 ABC-ATPase subunit interface; other site 696748004465 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 696748004466 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 696748004467 dimer interface [polypeptide binding]; other site 696748004468 conserved gate region; other site 696748004469 putative PBP binding loops; other site 696748004470 ABC-ATPase subunit interface; other site 696748004471 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 696748004472 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 696748004473 peptide binding site [polypeptide binding]; other site 696748004474 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 696748004475 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 696748004476 peptide binding site [polypeptide binding]; other site 696748004477 transaldolase-like protein; Provisional; Region: PTZ00411 696748004478 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 696748004479 active site 696748004480 dimer interface [polypeptide binding]; other site 696748004481 catalytic residue [active] 696748004482 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 696748004483 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 696748004484 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 696748004485 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 696748004486 Methyltransferase domain; Region: Methyltransf_26; pfam13659 696748004487 transcriptional regulator NarP; Provisional; Region: PRK10403 696748004488 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 696748004489 active site 696748004490 phosphorylation site [posttranslational modification] 696748004491 intermolecular recognition site; other site 696748004492 dimerization interface [polypeptide binding]; other site 696748004493 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 696748004494 DNA binding residues [nucleotide binding] 696748004495 dimerization interface [polypeptide binding]; other site 696748004496 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 696748004497 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 696748004498 Ca binding site [ion binding]; other site 696748004499 active site 696748004500 catalytic site [active] 696748004501 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 696748004502 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 696748004503 active site turn [active] 696748004504 phosphorylation site [posttranslational modification] 696748004505 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 696748004506 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 696748004507 putative global regulator; Reviewed; Region: PRK09559 696748004508 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 696748004509 hypothetical protein; Provisional; Region: PRK11820 696748004510 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 696748004511 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 696748004512 ribonuclease PH; Reviewed; Region: rph; PRK00173 696748004513 Ribonuclease PH; Region: RNase_PH_bact; cd11362 696748004514 hexamer interface [polypeptide binding]; other site 696748004515 active site 696748004516 glutaredoxin 1; Provisional; Region: grxA; PRK11200 696748004517 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 696748004518 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 696748004519 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 696748004520 G1 box; other site 696748004521 putative GEF interaction site [polypeptide binding]; other site 696748004522 GTP/Mg2+ binding site [chemical binding]; other site 696748004523 Switch I region; other site 696748004524 G2 box; other site 696748004525 G3 box; other site 696748004526 Switch II region; other site 696748004527 G4 box; other site 696748004528 G5 box; other site 696748004529 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 696748004530 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 696748004531 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 696748004532 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 696748004533 catalytic residue [active] 696748004534 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 696748004535 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 696748004536 active site 696748004537 motif I; other site 696748004538 motif II; other site 696748004539 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 696748004540 two-component response regulator; Provisional; Region: PRK11173 696748004541 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 696748004542 active site 696748004543 phosphorylation site [posttranslational modification] 696748004544 intermolecular recognition site; other site 696748004545 dimerization interface [polypeptide binding]; other site 696748004546 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 696748004547 DNA binding site [nucleotide binding] 696748004548 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 696748004549 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 696748004550 active site 696748004551 metal binding site [ion binding]; metal-binding site 696748004552 Diadenosine tetraphosphatase and related serine/threonine protein phosphatases [Signal transduction mechanisms]; Region: ApaH; COG0639 696748004553 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 696748004554 non-specific DNA binding site [nucleotide binding]; other site 696748004555 salt bridge; other site 696748004556 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 696748004557 sequence-specific DNA binding site [nucleotide binding]; other site 696748004558 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 696748004559 active site 696748004560 nucleotide binding site [chemical binding]; other site 696748004561 HIGH motif; other site 696748004562 KMSKS motif; other site 696748004563 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 696748004564 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 696748004565 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 696748004566 active site 696748004567 Riboflavin kinase; Region: Flavokinase; smart00904 696748004568 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 696748004569 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 696748004570 active site 696748004571 HIGH motif; other site 696748004572 nucleotide binding site [chemical binding]; other site 696748004573 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 696748004574 active site 696748004575 KMSKS motif; other site 696748004576 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 696748004577 tRNA binding surface [nucleotide binding]; other site 696748004578 anticodon binding site; other site 696748004579 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 696748004580 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 696748004581 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 696748004582 domain interface [polypeptide binding]; other site 696748004583 putative active site [active] 696748004584 catalytic site [active] 696748004585 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 696748004586 domain interface [polypeptide binding]; other site 696748004587 putative active site [active] 696748004588 catalytic site [active] 696748004589 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 696748004590 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 696748004591 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 696748004592 Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49); Region: G6PD_bact; pfam10786 696748004593 GTPase CgtA; Reviewed; Region: obgE; PRK12298 696748004594 GTP1/OBG; Region: GTP1_OBG; pfam01018 696748004595 Obg GTPase; Region: Obg; cd01898 696748004596 G1 box; other site 696748004597 GTP/Mg2+ binding site [chemical binding]; other site 696748004598 Switch I region; other site 696748004599 G2 box; other site 696748004600 G3 box; other site 696748004601 Switch II region; other site 696748004602 G4 box; other site 696748004603 G5 box; other site 696748004604 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 696748004605 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 696748004606 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 696748004607 active site 696748004608 HIGH motif; other site 696748004609 KMSK motif region; other site 696748004610 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 696748004611 tRNA binding surface [nucleotide binding]; other site 696748004612 anticodon binding site; other site 696748004613 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 696748004614 putative metal binding site [ion binding]; other site 696748004615 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 696748004616 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 696748004617 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 696748004618 GTP-binding protein YchF; Reviewed; Region: PRK09601 696748004619 YchF GTPase; Region: YchF; cd01900 696748004620 G1 box; other site 696748004621 GTP/Mg2+ binding site [chemical binding]; other site 696748004622 Switch I region; other site 696748004623 G2 box; other site 696748004624 Switch II region; other site 696748004625 G3 box; other site 696748004626 G4 box; other site 696748004627 G5 box; other site 696748004628 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 696748004629 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 696748004630 putative active site [active] 696748004631 catalytic residue [active] 696748004632 Protein of unknown function (DUF805); Region: DUF805; pfam05656 696748004633 Protein of unknown function (DUF805); Region: DUF805; pfam05656 696748004634 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 696748004635 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 696748004636 G1 box; other site 696748004637 putative GEF interaction site [polypeptide binding]; other site 696748004638 GTP/Mg2+ binding site [chemical binding]; other site 696748004639 Switch I region; other site 696748004640 G2 box; other site 696748004641 G3 box; other site 696748004642 Switch II region; other site 696748004643 G4 box; other site 696748004644 G5 box; other site 696748004645 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 696748004646 YadA-like C-terminal region; Region: YadA; pfam03895 696748004647 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 696748004648 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 696748004649 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 696748004650 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 696748004651 dimer interface [polypeptide binding]; other site 696748004652 conserved gate region; other site 696748004653 putative PBP binding loops; other site 696748004654 ABC-ATPase subunit interface; other site 696748004655 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 696748004656 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 696748004657 dimer interface [polypeptide binding]; other site 696748004658 conserved gate region; other site 696748004659 putative PBP binding loops; other site 696748004660 ABC-ATPase subunit interface; other site 696748004661 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 696748004662 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 696748004663 Walker A/P-loop; other site 696748004664 ATP binding site [chemical binding]; other site 696748004665 Q-loop/lid; other site 696748004666 ABC transporter signature motif; other site 696748004667 Walker B; other site 696748004668 D-loop; other site 696748004669 H-loop/switch region; other site 696748004670 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 696748004671 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 696748004672 Walker A/P-loop; other site 696748004673 ATP binding site [chemical binding]; other site 696748004674 Q-loop/lid; other site 696748004675 ABC transporter signature motif; other site 696748004676 Walker B; other site 696748004677 D-loop; other site 696748004678 H-loop/switch region; other site 696748004679 recombination and repair protein; Provisional; Region: PRK10869 696748004680 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 696748004681 Walker A/P-loop; other site 696748004682 ATP binding site [chemical binding]; other site 696748004683 Q-loop/lid; other site 696748004684 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 696748004685 Q-loop/lid; other site 696748004686 ABC transporter signature motif; other site 696748004687 Walker B; other site 696748004688 D-loop; other site 696748004689 H-loop/switch region; other site 696748004690 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 696748004691 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 696748004692 cell division protein FtsZ; Region: ftsZ; TIGR00065 696748004693 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 696748004694 nucleotide binding site [chemical binding]; other site 696748004695 SulA interaction site; other site 696748004696 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 696748004697 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 696748004698 nucleotide binding site [chemical binding]; other site 696748004699 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 696748004700 Cell division protein FtsA; Region: FtsA; pfam14450 696748004701 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 696748004702 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 696748004703 Cell division protein FtsQ; Region: FtsQ; pfam03799 696748004704 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 696748004705 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 696748004706 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 696748004707 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 696748004708 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 696748004709 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 696748004710 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 696748004711 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 696748004712 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 696748004713 active site 696748004714 homodimer interface [polypeptide binding]; other site 696748004715 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 696748004716 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 696748004717 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 696748004718 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 696748004719 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 696748004720 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 696748004721 Mg++ binding site [ion binding]; other site 696748004722 putative catalytic motif [active] 696748004723 putative substrate binding site [chemical binding]; other site 696748004724 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 696748004725 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 696748004726 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 696748004727 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 696748004728 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 696748004729 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 696748004730 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 696748004731 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 696748004732 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 696748004733 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 696748004734 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 696748004735 Cell division protein FtsL; Region: FtsL; pfam04999 696748004736 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 696748004737 MraW methylase family; Region: Methyltransf_5; pfam01795 696748004738 cell division protein MraZ; Reviewed; Region: PRK00326 696748004739 MraZ protein; Region: MraZ; pfam02381 696748004740 MraZ protein; Region: MraZ; pfam02381 696748004741 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 696748004742 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 696748004743 acid phosphatase/phosphotransferase; Provisional; Region: aphA; PRK11009 696748004744 ornithine carbamoyltransferase; Provisional; Region: PRK01713 696748004745 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 696748004746 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 696748004747 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 696748004748 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 696748004749 putative substrate binding site [chemical binding]; other site 696748004750 nucleotide binding site [chemical binding]; other site 696748004751 nucleotide binding site [chemical binding]; other site 696748004752 homodimer interface [polypeptide binding]; other site 696748004753 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 696748004754 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 696748004755 active site turn [active] 696748004756 phosphorylation site [posttranslational modification] 696748004757 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 696748004758 ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840 696748004759 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 696748004760 Walker A/P-loop; other site 696748004761 ATP binding site [chemical binding]; other site 696748004762 Q-loop/lid; other site 696748004763 ABC transporter signature motif; other site 696748004764 Walker B; other site 696748004765 D-loop; other site 696748004766 H-loop/switch region; other site 696748004767 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 696748004768 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 696748004769 dimer interface [polypeptide binding]; other site 696748004770 conserved gate region; other site 696748004771 putative PBP binding loops; other site 696748004772 ABC-ATPase subunit interface; other site 696748004773 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 696748004774 putative PBP binding loops; other site 696748004775 ABC-ATPase subunit interface; other site 696748004776 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 696748004777 dimerization domain swap beta strand [polypeptide binding]; other site 696748004778 regulatory protein interface [polypeptide binding]; other site 696748004779 active site 696748004780 regulatory phosphorylation site [posttranslational modification]; other site 696748004781 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 696748004782 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 696748004783 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 696748004784 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 696748004785 PTS system glucose-specific transporter subunit; Provisional; Region: PRK09439 696748004786 HPr interaction site; other site 696748004787 glycerol kinase (GK) interaction site [polypeptide binding]; other site 696748004788 active site 696748004789 phosphorylation site [posttranslational modification] 696748004790 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 696748004791 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 696748004792 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 696748004793 FeS/SAM binding site; other site 696748004794 TRAM domain; Region: TRAM; pfam01938 696748004795 Predicted membrane protein [Function unknown]; Region: COG3059 696748004796 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 696748004797 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 696748004798 Multicopper oxidase; Region: Cu-oxidase; pfam00394 696748004799 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 696748004800 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 696748004801 putative substrate binding site [chemical binding]; other site 696748004802 putative ATP binding site [chemical binding]; other site 696748004803 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 696748004804 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 696748004805 substrate binding [chemical binding]; other site 696748004806 active site 696748004807 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 696748004808 D-fructose-responsive transcription factor; Region: fruct_sucro_rep; TIGR02417 696748004809 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 696748004810 DNA binding site [nucleotide binding] 696748004811 domain linker motif; other site 696748004812 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 696748004813 dimerization interface [polypeptide binding]; other site 696748004814 ligand binding site [chemical binding]; other site 696748004815 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 696748004816 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 696748004817 CPxP motif; other site 696748004818 transcription-repair coupling factor; Provisional; Region: PRK10689 696748004819 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 696748004820 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 696748004821 ATP binding site [chemical binding]; other site 696748004822 putative Mg++ binding site [ion binding]; other site 696748004823 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 696748004824 nucleotide binding region [chemical binding]; other site 696748004825 ATP-binding site [chemical binding]; other site 696748004826 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 696748004827 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 696748004828 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 696748004829 aminopeptidase N; Provisional; Region: pepN; PRK14015 696748004830 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 696748004831 active site 696748004832 Zn binding site [ion binding]; other site 696748004833 Transposase; Region: HTH_Tnp_1; cl17663 696748004834 Predicted membrane protein [Function unknown]; Region: COG3671 696748004835 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 696748004836 dimer interface [polypeptide binding]; other site 696748004837 allosteric magnesium binding site [ion binding]; other site 696748004838 active site 696748004839 aspartate-rich active site metal binding site; other site 696748004840 Schiff base residues; other site 696748004841 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 696748004842 sec-independent translocase; Provisional; Region: PRK01770 696748004843 twin arginine translocase protein A; Provisional; Region: tatA; PRK01833 696748004844 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 696748004845 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 696748004846 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 696748004847 SCP-2 sterol transfer family; Region: SCP2; pfam02036 696748004848 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 696748004849 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 696748004850 S-adenosylmethionine binding site [chemical binding]; other site 696748004851 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 696748004852 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 696748004853 Cl binding site [ion binding]; other site 696748004854 oligomer interface [polypeptide binding]; other site 696748004855 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 696748004856 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 696748004857 S-adenosylmethionine binding site [chemical binding]; other site 696748004858 hypothetical protein; Provisional; Region: PRK11027 696748004859 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 696748004860 pyridoxal 5'-phosphate binding site [chemical binding]; other site 696748004861 catalytic residue [active] 696748004862 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06931 696748004863 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 696748004864 inhibitor-cofactor binding pocket; inhibition site 696748004865 pyridoxal 5'-phosphate binding site [chemical binding]; other site 696748004866 catalytic residue [active] 696748004867 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 696748004868 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 696748004869 hypothetical protein; Reviewed; Region: PRK00024 696748004870 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 696748004871 MPN+ (JAMM) motif; other site 696748004872 Zinc-binding site [ion binding]; other site 696748004873 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 696748004874 Flavoprotein; Region: Flavoprotein; pfam02441 696748004875 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 696748004876 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 696748004877 trimer interface [polypeptide binding]; other site 696748004878 active site 696748004879 division inhibitor protein; Provisional; Region: slmA; PRK09480 696748004880 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 696748004881 hypothetical protein; Provisional; Region: PRK04966 696748004882 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 696748004883 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 696748004884 ligand binding site [chemical binding]; other site 696748004885 flexible hinge region; other site 696748004886 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 696748004887 putative switch regulator; other site 696748004888 non-specific DNA interactions [nucleotide binding]; other site 696748004889 DNA binding site [nucleotide binding] 696748004890 sequence specific DNA binding site [nucleotide binding]; other site 696748004891 putative cAMP binding site [chemical binding]; other site 696748004892 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523 696748004893 metal binding site [ion binding]; metal-binding site 696748004894 GTPase HflX; Provisional; Region: PRK11058 696748004895 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 696748004896 HflX GTPase family; Region: HflX; cd01878 696748004897 G1 box; other site 696748004898 GTP/Mg2+ binding site [chemical binding]; other site 696748004899 Switch I region; other site 696748004900 G2 box; other site 696748004901 G3 box; other site 696748004902 Switch II region; other site 696748004903 G4 box; other site 696748004904 G5 box; other site 696748004905 Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49); Region: G6PD_bact; pfam10786 696748004906 bacterial Hfq-like; Region: Hfq; cd01716 696748004907 hexamer interface [polypeptide binding]; other site 696748004908 Sm1 motif; other site 696748004909 RNA binding site [nucleotide binding]; other site 696748004910 Sm2 motif; other site 696748004911 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 696748004912 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 696748004913 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 696748004914 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 696748004915 NAD binding site [chemical binding]; other site 696748004916 substrate binding site [chemical binding]; other site 696748004917 catalytic Zn binding site [ion binding]; other site 696748004918 tetramer interface [polypeptide binding]; other site 696748004919 structural Zn binding site [ion binding]; other site 696748004920 DNA mismatch repair protein MutL; Region: mutl; TIGR00585 696748004921 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 696748004922 ATP binding site [chemical binding]; other site 696748004923 Mg2+ binding site [ion binding]; other site 696748004924 G-X-G motif; other site 696748004925 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 696748004926 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 696748004927 ATP binding site [chemical binding]; other site 696748004928 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 696748004929 Transferrin binding protein-like solute binding protein; Region: Lipoprotein_5; pfam01298 696748004930 Transferrin binding protein-like solute binding protein; Region: Lipoprotein_5; pfam01298 696748004931 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 696748004932 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 696748004933 N-terminal plug; other site 696748004934 ligand-binding site [chemical binding]; other site 696748004935 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 696748004936 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 696748004937 putative catalytic cysteine [active] 696748004938 hypothetical protein; Reviewed; Region: PRK01637 696748004939 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 696748004940 putative active site [active] 696748004941 dimerization interface [polypeptide binding]; other site 696748004942 putative tRNAtyr binding site [nucleotide binding]; other site 696748004943 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 696748004944 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 696748004945 putative sugar binding sites [chemical binding]; other site 696748004946 Q-X-W motif; other site 696748004947 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560 696748004948 Predicted membrane protein [Function unknown]; Region: COG2510 696748004949 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 696748004950 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 696748004951 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 696748004952 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 696748004953 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 696748004954 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 696748004955 dimer interface [polypeptide binding]; other site 696748004956 ADP-ribose binding site [chemical binding]; other site 696748004957 active site 696748004958 nudix motif; other site 696748004959 metal binding site [ion binding]; metal-binding site 696748004960 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 696748004961 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 696748004962 active site 696748004963 metal binding site [ion binding]; metal-binding site 696748004964 hexamer interface [polypeptide binding]; other site 696748004965 glutamine synthetase; Provisional; Region: glnA; PRK09469 696748004966 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 696748004967 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 696748004968 Haemolytic domain; Region: Haemolytic; pfam01809 696748004969 ribonuclease P; Reviewed; Region: rnpA; PRK01732 696748004970 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 696748004971 ferrochelatase; Reviewed; Region: hemH; PRK00035 696748004972 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 696748004973 C-terminal domain interface [polypeptide binding]; other site 696748004974 active site 696748004975 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 696748004976 active site 696748004977 N-terminal domain interface [polypeptide binding]; other site 696748004978 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 696748004979 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 696748004980 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 696748004981 Peptidase family M23; Region: Peptidase_M23; pfam01551 696748004982 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12407 696748004983 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 696748004984 Predicted membrane protein [Function unknown]; Region: COG1238 696748004985 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 696748004986 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 696748004987 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 696748004988 Permutation of conserved domain; other site 696748004989 active site 696748004990 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 696748004991 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 696748004992 triosephosphate isomerase; Provisional; Region: PRK14567 696748004993 substrate binding site [chemical binding]; other site 696748004994 dimer interface [polypeptide binding]; other site 696748004995 catalytic triad [active] 696748004996 Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848 696748004997 catalytic triad [active] 696748004998 putative active site [active] 696748004999 autotransporter-associated beta strand repeat; Region: autotrns_rpt; TIGR02601 696748005000 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 696748005001 Autotransporter beta-domain; Region: Autotransporter; pfam03797 696748005002 PgaD-like protein; Region: PgaD; cl14676 696748005003 poly-beta-1,6 N-acetyl-D-glucosamine synthase; Region: PgaC_IcaA; TIGR03937 696748005004 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 696748005005 DXD motif; other site 696748005006 poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB; Region: deacetyl_PgaB; TIGR03938 696748005007 N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964 696748005008 putative active site [active] 696748005009 putative metal binding site [ion binding]; other site 696748005010 poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA; Region: PGA_TPR_OMP; TIGR03939 696748005011 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 696748005012 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 696748005013 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 696748005014 acyl-activating enzyme (AAE) consensus motif; other site 696748005015 putative AMP binding site [chemical binding]; other site 696748005016 putative active site [active] 696748005017 putative CoA binding site [chemical binding]; other site 696748005018 Site-specific recombinase; Region: SpecificRecomb; cl15411 696748005019 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 696748005020 active site 696748005021 phosphate binding residues; other site 696748005022 catalytic residues [active] 696748005023 VacJ like lipoprotein; Region: VacJ; cl01073 696748005024 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 696748005025 dimerization interface [polypeptide binding]; other site 696748005026 DNA binding site [nucleotide binding] 696748005027 corepressor binding sites; other site 696748005028 Protein of unknown function (DUF997); Region: DUF997; pfam06196 696748005029 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 696748005030 Na binding site [ion binding]; other site 696748005031 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 696748005032 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 696748005033 CysD dimerization site [polypeptide binding]; other site 696748005034 G1 box; other site 696748005035 putative GEF interaction site [polypeptide binding]; other site 696748005036 GTP/Mg2+ binding site [chemical binding]; other site 696748005037 Switch I region; other site 696748005038 G2 box; other site 696748005039 G3 box; other site 696748005040 Switch II region; other site 696748005041 G4 box; other site 696748005042 G5 box; other site 696748005043 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 696748005044 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 696748005045 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 696748005046 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 696748005047 Active Sites [active] 696748005048 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 696748005049 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 696748005050 Active Sites [active] 696748005051 siroheme synthase; Provisional; Region: cysG; PRK10637 696748005052 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 696748005053 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 696748005054 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 696748005055 active site 696748005056 SAM binding site [chemical binding]; other site 696748005057 homodimer interface [polypeptide binding]; other site 696748005058 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 696748005059 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 696748005060 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 696748005061 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 696748005062 dimer interface [polypeptide binding]; other site 696748005063 conserved gate region; other site 696748005064 putative PBP binding loops; other site 696748005065 ABC-ATPase subunit interface; other site 696748005066 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 696748005067 dimer interface [polypeptide binding]; other site 696748005068 conserved gate region; other site 696748005069 putative PBP binding loops; other site 696748005070 ABC-ATPase subunit interface; other site 696748005071 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 696748005072 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 696748005073 Walker A/P-loop; other site 696748005074 ATP binding site [chemical binding]; other site 696748005075 Q-loop/lid; other site 696748005076 ABC transporter signature motif; other site 696748005077 Walker B; other site 696748005078 D-loop; other site 696748005079 H-loop/switch region; other site 696748005080 TOBE-like domain; Region: TOBE_3; pfam12857 696748005081 Transferrin binding protein-like solute binding protein; Region: Lipoprotein_5; pfam01298 696748005082 haemagglutination activity domain; Region: Haemagg_act; pfam05860 696748005083 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 696748005084 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 696748005085 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 696748005086 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 696748005087 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 696748005088 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cl00185 696748005089 Autotransporter beta-domain; Region: Autotransporter; pfam03797 696748005090 ketol-acid reductoisomerase; Validated; Region: PRK05225 696748005091 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 696748005092 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 696748005093 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 696748005094 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 696748005095 Paraquat-inducible protein A; Region: PqiA; pfam04403 696748005096 Paraquat-inducible protein A; Region: PqiA; pfam04403 696748005097 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 696748005098 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 696748005099 MerT mercuric transport protein; Region: MerT; cl03578 696748005100 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 696748005101 metal-binding site [ion binding] 696748005102 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 696748005103 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 696748005104 NAD(P) binding site [chemical binding]; other site 696748005105 catalytic residues [active] 696748005106 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 696748005107 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 696748005108 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 696748005109 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 696748005110 Immunoglobulin A1 protease; Region: Peptidase_S6; pfam02395 696748005111 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 696748005112 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 696748005113 Autotransporter beta-domain; Region: Autotransporter; pfam03797 696748005114 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 696748005115 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 696748005116 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 696748005117 AAA domain; Region: AAA_14; pfam13173 696748005118 Transcriptional regulator [Transcription]; Region: LysR; COG0583 696748005119 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 696748005120 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 696748005121 putative effector binding pocket; other site 696748005122 dimerization interface [polypeptide binding]; other site 696748005123 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 696748005124 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 696748005125 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 696748005126 conserved cys residue [active] 696748005127 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 696748005128 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 696748005129 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 696748005130 AAA domain; Region: AAA_14; pfam13173 696748005131 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 696748005132 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 696748005133 putative C-terminal domain interface [polypeptide binding]; other site 696748005134 putative GSH binding site (G-site) [chemical binding]; other site 696748005135 putative dimer interface [polypeptide binding]; other site 696748005136 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 696748005137 N-terminal domain interface [polypeptide binding]; other site 696748005138 dimer interface [polypeptide binding]; other site 696748005139 substrate binding pocket (H-site) [chemical binding]; other site 696748005140 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 696748005141 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 696748005142 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 696748005143 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 696748005144 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 696748005145 putative FMN binding site [chemical binding]; other site 696748005146 Protein of unknown function (DUF419); Region: DUF419; pfam04237 696748005147 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 696748005148 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 696748005149 Old yellow enzyme (OYE)-related FMN binding domain, group 2. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733 696748005150 putative active site [active] 696748005151 putative FMN binding site [chemical binding]; other site 696748005152 putative substrate binding site [chemical binding]; other site 696748005153 putative catalytic residue [active] 696748005154 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 696748005155 dimerization interface [polypeptide binding]; other site 696748005156 putative DNA binding site [nucleotide binding]; other site 696748005157 putative Zn2+ binding site [ion binding]; other site 696748005158 magnesium-transporting ATPase; Provisional; Region: PRK15122 696748005159 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 696748005160 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 696748005161 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 696748005162 dinuclear metal binding motif [ion binding]; other site 696748005163 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 696748005164 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 696748005165 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 696748005166 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 696748005167 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 696748005168 dimer interface [polypeptide binding]; other site 696748005169 FMN binding site [chemical binding]; other site 696748005170 Uncharacterized conserved protein [Function unknown]; Region: COG1359 696748005171 Transcriptional regulator [Transcription]; Region: LysR; COG0583 696748005172 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 696748005173 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 696748005174 putative effector binding pocket; other site 696748005175 dimerization interface [polypeptide binding]; other site 696748005176 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 696748005177 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 696748005178 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_3; cd08461 696748005179 putative substrate binding pocket [chemical binding]; other site 696748005180 putative dimerization interface [polypeptide binding]; other site 696748005181 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 696748005182 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 696748005183 active site 696748005184 FMN binding site [chemical binding]; other site 696748005185 substrate binding site [chemical binding]; other site 696748005186 homotetramer interface [polypeptide binding]; other site 696748005187 catalytic residue [active] 696748005188 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 696748005189 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 696748005190 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 696748005191 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 696748005192 trimer interface [polypeptide binding]; other site 696748005193 active site 696748005194 substrate binding site [chemical binding]; other site 696748005195 CoA binding site [chemical binding]; other site 696748005196 Dehydroquinase class II; Region: DHquinase_II; pfam01220 696748005197 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 696748005198 active site 696748005199 trimer interface [polypeptide binding]; other site 696748005200 dimer interface [polypeptide binding]; other site 696748005201 Mannosyltransferase OCH1 and related enzymes [Cell envelope biogenesis, outer membrane]; Region: OCH1; COG3774 696748005202 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 696748005203 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 696748005204 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 696748005205 carboxyltransferase (CT) interaction site; other site 696748005206 biotinylation site [posttranslational modification]; other site 696748005207 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 696748005208 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 696748005209 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 696748005210 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 696748005211 putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobA/MobB; Provisional; Region: PRK14489 696748005212 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 696748005213 GTP binding site; other site 696748005214 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 696748005215 Walker A motif; other site 696748005216 Protein of unknown function (DUF1040); Region: DUF1040; cl01176 696748005217 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 696748005218 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 696748005219 catalytic residues [active] 696748005220 hinge region; other site 696748005221 alpha helical domain; other site 696748005222 Sporulation related domain; Region: SPOR; pfam05036 696748005223 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 696748005224 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 696748005225 S-adenosylmethionine binding site [chemical binding]; other site 696748005226 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 696748005227 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 696748005228 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 696748005229 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 696748005230 metal binding site [ion binding]; metal-binding site 696748005231 dimer interface [polypeptide binding]; other site 696748005232 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 696748005233 ArsC family; Region: ArsC; pfam03960 696748005234 putative catalytic residues [active] 696748005235 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 696748005236 dihydropteroate synthase; Region: DHPS; TIGR01496 696748005237 substrate binding pocket [chemical binding]; other site 696748005238 dimer interface [polypeptide binding]; other site 696748005239 inhibitor binding site; inhibition site 696748005240 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 696748005241 active site 696748005242 NTP binding site [chemical binding]; other site 696748005243 metal binding triad [ion binding]; metal-binding site 696748005244 antibiotic binding site [chemical binding]; other site 696748005245 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; cl17552 696748005246 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 696748005247 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 696748005248 RNA binding surface [nucleotide binding]; other site 696748005249 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 696748005250 active site 696748005251 mechanosensitive channel MscS; Provisional; Region: PRK10334 696748005252 Mechanosensitive ion channel; Region: MS_channel; pfam00924 696748005253 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 696748005254 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 696748005255 Putative esterase; Region: Esterase; pfam00756 696748005256 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 696748005257 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 696748005258 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 696748005259 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 696748005260 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 696748005261 S-adenosylmethionine binding site [chemical binding]; other site 696748005262 Peptidase family M48; Region: Peptidase_M48; pfam01435 696748005263 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 696748005264 putative active site [active] 696748005265 Ap4A binding site [chemical binding]; other site 696748005266 nudix motif; other site 696748005267 putative metal binding site [ion binding]; other site 696748005268 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 696748005269 potential frameshift: common BLAST hit: gi|126209355|ref|YP_001054580.1| prolipoprotein diacylglyceryl transferase 696748005270 phosphoglycolate phosphatase; Provisional; Region: PRK13222 696748005271 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 696748005272 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 696748005273 motif II; other site 696748005274 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 696748005275 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 696748005276 active site 696748005277 HIGH motif; other site 696748005278 dimer interface [polypeptide binding]; other site 696748005279 KMSKS motif; other site 696748005280 Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848 696748005281 catalytic triad [active] 696748005282 putative active site [active] 696748005283 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 696748005284 Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625 696748005285 Autotransporter beta-domain; Region: Autotransporter; pfam03797 696748005286 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 696748005287 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 696748005288 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 696748005289 3-hydroxydecanoyl-(acyl carrier protein) dehydratase; Validated; Region: PRK05174 696748005290 active site 2 [active] 696748005291 active site 1 [active] 696748005292 Protein of unknown function (DUF2572); Region: DUF2572; pfam10833 696748005293 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 696748005294 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 696748005295 protease3; Provisional; Region: PRK15101 696748005296 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 696748005297 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 696748005298 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 696748005299 chaperone protein DnaJ; Provisional; Region: PRK10767 696748005300 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 696748005301 HSP70 interaction site [polypeptide binding]; other site 696748005302 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 696748005303 substrate binding site [polypeptide binding]; other site 696748005304 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 696748005305 Zn binding sites [ion binding]; other site 696748005306 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 696748005307 dimer interface [polypeptide binding]; other site 696748005308 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 696748005309 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 696748005310 nucleotide binding site [chemical binding]; other site 696748005311 xylulokinase; Provisional; Region: PRK15027 696748005312 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 696748005313 N- and C-terminal domain interface [polypeptide binding]; other site 696748005314 active site 696748005315 MgATP binding site [chemical binding]; other site 696748005316 catalytic site [active] 696748005317 metal binding site [ion binding]; metal-binding site 696748005318 xylulose binding site [chemical binding]; other site 696748005319 homodimer interface [polypeptide binding]; other site 696748005320 xylose isomerase; Provisional; Region: PRK05474 696748005321 xylose isomerase; Region: xylose_isom_A; TIGR02630 696748005322 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 696748005323 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 696748005324 putative ligand binding site [chemical binding]; other site 696748005325 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 696748005326 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 696748005327 Walker A/P-loop; other site 696748005328 ATP binding site [chemical binding]; other site 696748005329 Q-loop/lid; other site 696748005330 ABC transporter signature motif; other site 696748005331 Walker B; other site 696748005332 D-loop; other site 696748005333 H-loop/switch region; other site 696748005334 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 696748005335 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 696748005336 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 696748005337 TM-ABC transporter signature motif; other site 696748005338 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 696748005339 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 696748005340 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 696748005341 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 696748005342 inhibitor binding site; inhibition site 696748005343 active site 696748005344 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 696748005345 putative dimerization interface [polypeptide binding]; other site 696748005346 Transcriptional regulators [Transcription]; Region: PurR; COG1609 696748005347 putative ligand binding site [chemical binding]; other site 696748005348 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 696748005349 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 696748005350 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 696748005351 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 696748005352 active site 696748005353 Zn binding site [ion binding]; other site 696748005354 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 696748005355 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 696748005356 Flavodoxin; Region: Flavodoxin_1; pfam00258 696748005357 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 696748005358 FAD binding pocket [chemical binding]; other site 696748005359 FAD binding motif [chemical binding]; other site 696748005360 catalytic residues [active] 696748005361 NAD binding pocket [chemical binding]; other site 696748005362 phosphate binding motif [ion binding]; other site 696748005363 beta-alpha-beta structure motif; other site 696748005364 sulfite reductase subunit beta; Provisional; Region: PRK13504 696748005365 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 696748005366 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 696748005367 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 696748005368 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 696748005369 Ligand binding site; other site 696748005370 metal-binding site 696748005371 glutamate racemase; Provisional; Region: PRK00865 696748005372 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: Cah; COG3338 696748005373 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 696748005374 active site 696748005375 zinc binding site [ion binding]; other site 696748005376 Chorismate lyase; Region: Chor_lyase; cl01230 696748005377 uridine phosphorylase; Provisional; Region: PRK11178 696748005378 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 696748005379 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 696748005380 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 696748005381 putative DNA binding site [nucleotide binding]; other site 696748005382 putative Zn2+ binding site [ion binding]; other site 696748005383 AsnC family; Region: AsnC_trans_reg; pfam01037 696748005384 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 696748005385 dimer interface [polypeptide binding]; other site 696748005386 active site 696748005387 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 696748005388 TMAO/DMSO reductase; Reviewed; Region: PRK05363 696748005389 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 696748005390 Moco binding site; other site 696748005391 metal coordination site [ion binding]; other site 696748005392 RNA polymerase sigma factor; Provisional; Region: PRK12530 696748005393 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 696748005394 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 696748005395 DNA binding residues [nucleotide binding] 696748005396 Putative zinc-finger; Region: zf-HC2; pfam13490 696748005397 prolyl-tRNA synthetase; Provisional; Region: PRK09194 696748005398 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 696748005399 dimer interface [polypeptide binding]; other site 696748005400 motif 1; other site 696748005401 active site 696748005402 motif 2; other site 696748005403 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 696748005404 putative deacylase active site [active] 696748005405 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 696748005406 active site 696748005407 motif 3; other site 696748005408 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 696748005409 anticodon binding site; other site 696748005410 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 696748005411 Pathogenicity locus; Region: Cdd1; pfam11731 696748005412 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 696748005413 generic binding surface II; other site 696748005414 ssDNA binding site; other site 696748005415 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 696748005416 ATP binding site [chemical binding]; other site 696748005417 putative Mg++ binding site [ion binding]; other site 696748005418 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 696748005419 nucleotide binding region [chemical binding]; other site 696748005420 ATP-binding site [chemical binding]; other site 696748005421 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 696748005422 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 696748005423 active site turn [active] 696748005424 phosphorylation site [posttranslational modification] 696748005425 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 696748005426 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 696748005427 HPr interaction site; other site 696748005428 glycerol kinase (GK) interaction site [polypeptide binding]; other site 696748005429 active site 696748005430 phosphorylation site [posttranslational modification] 696748005431 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 696748005432 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 696748005433 active site 696748005434 motif I; other site 696748005435 motif II; other site 696748005436 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 696748005437 Predicted peptidase [General function prediction only]; Region: COG4099 696748005438 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 696748005439 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 696748005440 beta-galactosidase; Region: BGL; TIGR03356 696748005441 transcriptional antiterminator BglG; Provisional; Region: PRK09772 696748005442 CAT RNA binding domain; Region: CAT_RBD; smart01061 696748005443 PRD domain; Region: PRD; pfam00874 696748005444 PRD domain; Region: PRD; pfam00874 696748005445 phosphoenolpyruvate synthase; Validated; Region: PRK06464 696748005446 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 696748005447 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 696748005448 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 696748005449 PEP synthetase regulatory protein; Provisional; Region: PRK05339 696748005450 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 696748005451 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 696748005452 Zn2+ binding site [ion binding]; other site 696748005453 Mg2+ binding site [ion binding]; other site 696748005454 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 696748005455 synthetase active site [active] 696748005456 NTP binding site [chemical binding]; other site 696748005457 metal binding site [ion binding]; metal-binding site 696748005458 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 696748005459 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 696748005460 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 696748005461 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 696748005462 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 696748005463 substrate binding site [chemical binding]; other site 696748005464 oxyanion hole (OAH) forming residues; other site 696748005465 trimer interface [polypeptide binding]; other site 696748005466 penicillin-binding protein 1B; Region: PBP_1b; TIGR02071 696748005467 Transglycosylase; Region: Transgly; pfam00912 696748005468 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 696748005469 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 696748005470 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 696748005471 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 696748005472 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 696748005473 substrate binding site [chemical binding]; other site 696748005474 hexamer interface [polypeptide binding]; other site 696748005475 metal binding site [ion binding]; metal-binding site 696748005476 acyl carrier protein; Provisional; Region: acpP; PRK00982 696748005477 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 696748005478 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 696748005479 dimerization interface [polypeptide binding]; other site 696748005480 thymidylate kinase; Validated; Region: tmk; PRK00698 696748005481 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 696748005482 TMP-binding site; other site 696748005483 ATP-binding site [chemical binding]; other site 696748005484 DNA polymerase III subunit delta'; Validated; Region: PRK06871 696748005485 DNA polymerase III subunit delta'; Validated; Region: PRK08485 696748005486 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 696748005487 MltA-interacting protein MipA; Region: MipA; cl01504 696748005488 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 696748005489 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 696748005490 HlyD family secretion protein; Region: HlyD_3; pfam13437 696748005491 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 696748005492 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 696748005493 Walker A/P-loop; other site 696748005494 ATP binding site [chemical binding]; other site 696748005495 Q-loop/lid; other site 696748005496 ABC transporter signature motif; other site 696748005497 Walker B; other site 696748005498 D-loop; other site 696748005499 H-loop/switch region; other site 696748005500 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 696748005501 FtsX-like permease family; Region: FtsX; pfam02687 696748005502 MULE transposase domain; Region: MULE; pfam10551 696748005503 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 696748005504 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 696748005505 active site 696748005506 Protein of unknown function (DUF1523); Region: DUF1523; pfam07509 696748005507 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 696748005508 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 696748005509 putative active site [active] 696748005510 putative metal binding site [ion binding]; other site 696748005511 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 696748005512 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 696748005513 active site 696748005514 Protein of unknown function (DUF454); Region: DUF454; cl01063 696748005515 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 696748005516 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 696748005517 active site 696748005518 Int/Topo IB signature motif; other site 696748005519 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 696748005520 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 696748005521 S-adenosylmethionine binding site [chemical binding]; other site 696748005522 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 696748005523 DALR anticodon binding domain; Region: DALR_1; pfam05746 696748005524 Domain of unknown function (DUF3825); Region: DUF3825; pfam12873 696748005525 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 696748005526 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 696748005527 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 696748005528 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 696748005529 dimer interface [polypeptide binding]; other site 696748005530 motif 1; other site 696748005531 active site 696748005532 motif 2; other site 696748005533 motif 3; other site 696748005534 trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162 696748005535 trimethylamine N-oxide reductase I catalytic subunit; Provisional; Region: PRK15102 696748005536 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 696748005537 molybdopterin cofactor binding site [chemical binding]; other site 696748005538 substrate binding site [chemical binding]; other site 696748005539 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 696748005540 molybdopterin cofactor binding site; other site 696748005541 chaperone protein TorD; Validated; Region: torD; PRK04976 696748005542 ATP-grasp domain; Region: ATP-grasp_4; cl17255 696748005543 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 696748005544 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 696748005545 intersubunit interface [polypeptide binding]; other site 696748005546 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 696748005547 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 696748005548 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 696748005549 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 696748005550 Walker A/P-loop; other site 696748005551 ATP binding site [chemical binding]; other site 696748005552 Q-loop/lid; other site 696748005553 ABC transporter signature motif; other site 696748005554 Walker B; other site 696748005555 D-loop; other site 696748005556 H-loop/switch region; other site 696748005557 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 696748005558 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 696748005559 ABC-ATPase subunit interface; other site 696748005560 dimer interface [polypeptide binding]; other site 696748005561 putative PBP binding regions; other site 696748005562 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 696748005563 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 696748005564 intersubunit interface [polypeptide binding]; other site 696748005565 Uncharacterized conserved protein [Function unknown]; Region: COG2850 696748005566 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 696748005567 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 696748005568 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 696748005569 RimM N-terminal domain; Region: RimM; pfam01782 696748005570 PRC-barrel domain; Region: PRC; pfam05239 696748005571 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 696748005572 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 696748005573 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 696748005574 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 696748005575 alphaNTD homodimer interface [polypeptide binding]; other site 696748005576 alphaNTD - beta interaction site [polypeptide binding]; other site 696748005577 alphaNTD - beta' interaction site [polypeptide binding]; other site 696748005578 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 696748005579 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 696748005580 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 696748005581 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 696748005582 RNA binding surface [nucleotide binding]; other site 696748005583 30S ribosomal protein S11; Validated; Region: PRK05309 696748005584 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 696748005585 30S ribosomal protein S13; Region: bact_S13; TIGR03631 696748005586 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 696748005587 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 696748005588 SecY translocase; Region: SecY; pfam00344 696748005589 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 696748005590 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 696748005591 23S rRNA binding site [nucleotide binding]; other site 696748005592 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 696748005593 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 696748005594 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 696748005595 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 696748005596 23S rRNA interface [nucleotide binding]; other site 696748005597 L21e interface [polypeptide binding]; other site 696748005598 5S rRNA interface [nucleotide binding]; other site 696748005599 L27 interface [polypeptide binding]; other site 696748005600 L5 interface [polypeptide binding]; other site 696748005601 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 696748005602 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 696748005603 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 696748005604 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 696748005605 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 696748005606 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 696748005607 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 696748005608 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 696748005609 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 696748005610 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 696748005611 RNA binding site [nucleotide binding]; other site 696748005612 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 696748005613 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 696748005614 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 696748005615 23S rRNA interface [nucleotide binding]; other site 696748005616 putative translocon interaction site; other site 696748005617 signal recognition particle (SRP54) interaction site; other site 696748005618 L23 interface [polypeptide binding]; other site 696748005619 trigger factor interaction site; other site 696748005620 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 696748005621 23S rRNA interface [nucleotide binding]; other site 696748005622 5S rRNA interface [nucleotide binding]; other site 696748005623 putative antibiotic binding site [chemical binding]; other site 696748005624 L25 interface [polypeptide binding]; other site 696748005625 L27 interface [polypeptide binding]; other site 696748005626 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 696748005627 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 696748005628 G-X-X-G motif; other site 696748005629 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 696748005630 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 696748005631 protein-rRNA interface [nucleotide binding]; other site 696748005632 putative translocon binding site; other site 696748005633 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 696748005634 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 696748005635 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 696748005636 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 696748005637 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 696748005638 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 696748005639 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 696748005640 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 696748005641 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 696748005642 TfoX N-terminal domain; Region: TfoX_N; pfam04993 696748005643 TfoX C-terminal domain; Region: TfoX_C; pfam04994 696748005644 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 696748005645 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 696748005646 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 696748005647 Major Facilitator Superfamily; Region: MFS_1; pfam07690 696748005648 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696748005649 putative substrate translocation pore; other site 696748005650 selenocysteine synthase; Provisional; Region: PRK04311 696748005651 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 696748005652 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 696748005653 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 696748005654 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 696748005655 G1 box; other site 696748005656 putative GEF interaction site [polypeptide binding]; other site 696748005657 GTP/Mg2+ binding site [chemical binding]; other site 696748005658 Switch I region; other site 696748005659 G2 box; other site 696748005660 G3 box; other site 696748005661 Switch II region; other site 696748005662 G4 box; other site 696748005663 G5 box; other site 696748005664 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 696748005665 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 696748005666 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 696748005667 DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is...; Region: DEP; cl02442 696748005668 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 696748005669 ribosomal RNA small subunit methyltransferase RsmB; Region: rsmB; TIGR00563 696748005670 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 696748005671 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 696748005672 S-adenosylmethionine binding site [chemical binding]; other site 696748005673 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 696748005674 TrkA-N domain; Region: TrkA_N; pfam02254 696748005675 TrkA-C domain; Region: TrkA_C; pfam02080 696748005676 TrkA-N domain; Region: TrkA_N; pfam02254 696748005677 TrkA-C domain; Region: TrkA_C; pfam02080 696748005678 fumarate hydratase; Reviewed; Region: fumC; PRK00485 696748005679 Class II fumarases; Region: Fumarase_classII; cd01362 696748005680 active site 696748005681 tetramer interface [polypeptide binding]; other site 696748005682 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 696748005683 Methyltransferase domain; Region: Methyltransf_18; pfam12847 696748005684 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 696748005685 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 696748005686 protease TldD; Provisional; Region: tldD; PRK10735 696748005687 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 696748005688 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 696748005689 Ligand Binding Site [chemical binding]; other site 696748005690 TilS substrate binding domain; Region: TilS; pfam09179 696748005691 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 696748005692 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 696748005693 dimer interface [polypeptide binding]; other site 696748005694 catalytic triad [active] 696748005695 peroxidatic and resolving cysteines [active] 696748005696 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 696748005697 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 696748005698 putative acyl-acceptor binding pocket; other site 696748005699 FtsI repressor; Provisional; Region: PRK10883 696748005700 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 696748005701 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 696748005702 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 696748005703 pyridoxamine kinase; Validated; Region: PRK05756 696748005704 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 696748005705 dimer interface [polypeptide binding]; other site 696748005706 pyridoxal binding site [chemical binding]; other site 696748005707 ATP binding site [chemical binding]; other site 696748005708 Sialyltransferase PMO188; Region: PM0188; pfam11477 696748005709 elongation factor Tu; Reviewed; Region: PRK00049 696748005710 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 696748005711 G1 box; other site 696748005712 GEF interaction site [polypeptide binding]; other site 696748005713 GTP/Mg2+ binding site [chemical binding]; other site 696748005714 Switch I region; other site 696748005715 G2 box; other site 696748005716 G3 box; other site 696748005717 Switch II region; other site 696748005718 G4 box; other site 696748005719 G5 box; other site 696748005720 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 696748005721 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 696748005722 Antibiotic Binding Site [chemical binding]; other site 696748005723 pantothenate kinase; Provisional; Region: PRK05439 696748005724 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 696748005725 ATP-binding site [chemical binding]; other site 696748005726 CoA-binding site [chemical binding]; other site 696748005727 Mg2+-binding site [ion binding]; other site 696748005728 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 696748005729 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 696748005730 catalytic residues [active] 696748005731 central insert; other site 696748005732 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 696748005733 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 696748005734 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 696748005735 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 696748005736 binding surface 696748005737 TPR motif; other site 696748005738 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 696748005739 MPT binding site; other site 696748005740 trimer interface [polypeptide binding]; other site 696748005741 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 696748005742 Nitrogen regulatory protein P-II; Region: P-II; smart00938 696748005743 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 696748005744 lipoprotein signal peptidase; Provisional; Region: PRK14787 696748005745 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 696748005746 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 696748005747 Uncharacterized conserved protein [Function unknown]; Region: COG2938 696748005748 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 696748005749 Predicted membrane protein [Function unknown]; Region: COG4125 696748005750 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 696748005751 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 696748005752 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 696748005753 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 696748005754 non-specific DNA binding site [nucleotide binding]; other site 696748005755 salt bridge; other site 696748005756 sequence-specific DNA binding site [nucleotide binding]; other site 696748005757 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 696748005758 dimer interface [polypeptide binding]; other site 696748005759 FMN binding site [chemical binding]; other site 696748005760 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 696748005761 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 696748005762 putative NAD(P) binding site [chemical binding]; other site 696748005763 putative substrate binding site [chemical binding]; other site 696748005764 catalytic Zn binding site [ion binding]; other site 696748005765 structural Zn binding site [ion binding]; other site 696748005766 dimer interface [polypeptide binding]; other site 696748005767 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 696748005768 additional DNA contacts [nucleotide binding]; other site 696748005769 mismatch recognition site; other site 696748005770 active site 696748005771 zinc binding site [ion binding]; other site 696748005772 DNA intercalation site [nucleotide binding]; other site 696748005773 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 696748005774 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 696748005775 cofactor binding site; other site 696748005776 DNA binding site [nucleotide binding] 696748005777 substrate interaction site [chemical binding]; other site 696748005778 Protein of unknown function, DUF479; Region: DUF479; cl01203 696748005779 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 696748005780 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 696748005781 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 696748005782 TrkA-N domain; Region: TrkA_N; pfam02254 696748005783 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 696748005784 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 696748005785 active site 696748005786 nucleophile elbow; other site 696748005787 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 696748005788 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 696748005789 ligand binding site [chemical binding]; other site 696748005790 calcium binding site [ion binding]; other site 696748005791 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 696748005792 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 696748005793 Walker A/P-loop; other site 696748005794 ATP binding site [chemical binding]; other site 696748005795 Q-loop/lid; other site 696748005796 ABC transporter signature motif; other site 696748005797 Walker B; other site 696748005798 D-loop; other site 696748005799 H-loop/switch region; other site 696748005800 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 696748005801 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 696748005802 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 696748005803 TM-ABC transporter signature motif; other site 696748005804 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 696748005805 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 696748005806 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 696748005807 DNA binding residues [nucleotide binding] 696748005808 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 696748005809 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696748005810 putative substrate translocation pore; other site 696748005811 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696748005812 Transcriptional regulator [Transcription]; Region: LysR; COG0583 696748005813 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 696748005814 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 696748005815 putative effector binding pocket; other site 696748005816 putative dimerization interface [polypeptide binding]; other site 696748005817 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 696748005818 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 696748005819 catalytic tetrad [active] 696748005820 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 696748005821 Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like-3; cd12810 696748005822 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 696748005823 catalytic site [active] 696748005824 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 696748005825 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 696748005826 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 696748005827 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 696748005828 potential frameshift: common BLAST hit: gi|257126187|ref|YP_003164301.1| alpha/beta hydrolase fold protein 696748005829 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 696748005830 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 696748005831 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 696748005832 Protein of unknown function, DUF606; Region: DUF606; pfam04657 696748005833 Protein of unknown function, DUF606; Region: DUF606; pfam04657 696748005834 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 696748005835 NADH(P)-binding; Region: NAD_binding_10; pfam13460 696748005836 NAD(P) binding site [chemical binding]; other site 696748005837 putative active site [active] 696748005838 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 696748005839 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 696748005840 Domain of unknown function (DUF4405); Region: DUF4405; pfam14358 696748005841 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696748005842 putative substrate translocation pore; other site 696748005843 Transcriptional regulator [Transcription]; Region: LysR; COG0583 696748005844 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 696748005845 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 696748005846 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 696748005847 phosphate binding site [ion binding]; other site 696748005848 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 696748005849 malate:quinone oxidoreductase; Validated; Region: PRK05257 696748005850 Tannase and feruloyl esterase; Region: Tannase; pfam07519 696748005851 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 696748005852 TIGR01666 family membrane protein; Region: YCCS 696748005853 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 696748005854 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 696748005855 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 696748005856 threonine synthase; Validated; Region: PRK09225 696748005857 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 696748005858 catalytic residue [active] 696748005859 regulatory protein UhpC; Provisional; Region: PRK11663 696748005860 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696748005861 putative substrate translocation pore; other site 696748005862 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696748005863 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 696748005864 non-specific DNA binding site [nucleotide binding]; other site 696748005865 salt bridge; other site 696748005866 sequence-specific DNA binding site [nucleotide binding]; other site 696748005867 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 696748005868 HipA-like N-terminal domain; Region: HipA_N; pfam07805 696748005869 HipA-like C-terminal domain; Region: HipA_C; pfam07804 696748005870 Abi-like protein; Region: Abi_2; cl01988 696748005871 Abi-like protein; Region: Abi_2; pfam07751 696748005872 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 696748005873 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 696748005874 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 696748005875 dimerization interface [polypeptide binding]; other site 696748005876 ATP binding site [chemical binding]; other site 696748005877 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 696748005878 dimerization interface [polypeptide binding]; other site 696748005879 ATP binding site [chemical binding]; other site 696748005880 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 696748005881 putative active site [active] 696748005882 catalytic triad [active] 696748005883 Protein of unknown function, DUF399; Region: DUF399; pfam04187 696748005884 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 696748005885 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 696748005886 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 696748005887 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 696748005888 putative hemin binding site; other site 696748005889 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 696748005890 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 696748005891 ABC-ATPase subunit interface; other site 696748005892 dimer interface [polypeptide binding]; other site 696748005893 putative PBP binding regions; other site 696748005894 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 696748005895 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 696748005896 Walker A/P-loop; other site 696748005897 ATP binding site [chemical binding]; other site 696748005898 Q-loop/lid; other site 696748005899 ABC transporter signature motif; other site 696748005900 Walker B; other site 696748005901 D-loop; other site 696748005902 H-loop/switch region; other site 696748005903 Protein of unknown function (DUF1440); Region: DUF1440; pfam07274 696748005904 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 696748005905 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 696748005906 dimer interface [polypeptide binding]; other site 696748005907 conserved gate region; other site 696748005908 putative PBP binding loops; other site 696748005909 ABC-ATPase subunit interface; other site 696748005910 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 696748005911 dimer interface [polypeptide binding]; other site 696748005912 conserved gate region; other site 696748005913 putative PBP binding loops; other site 696748005914 ABC-ATPase subunit interface; other site 696748005915 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 696748005916 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 696748005917 Walker A/P-loop; other site 696748005918 ATP binding site [chemical binding]; other site 696748005919 Q-loop/lid; other site 696748005920 ABC transporter signature motif; other site 696748005921 Walker B; other site 696748005922 D-loop; other site 696748005923 H-loop/switch region; other site 696748005924 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 696748005925 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 696748005926 substrate binding pocket [chemical binding]; other site 696748005927 membrane-bound complex binding site; other site 696748005928 hinge residues; other site 696748005929 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsC; COG3563 696748005930 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 696748005931 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 696748005932 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 696748005933 active site 696748005934 dimer interface [polypeptide binding]; other site 696748005935 magnesium binding site [ion binding]; other site 696748005936 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 696748005937 active site 696748005938 phosphorylation site [posttranslational modification] 696748005939 PTS system ascorbate-specific transporter subunits IICB; Provisional; Region: PRK09548 696748005940 Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037 696748005941 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 696748005942 active site 696748005943 P-loop; other site 696748005944 phosphorylation site [posttranslational modification] 696748005945 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 696748005946 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 696748005947 transcriptional repressor UlaR; Provisional; Region: PRK13509 696748005948 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 696748005949 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 696748005950 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 696748005951 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 696748005952 AP (apurinic/apyrimidinic) site pocket; other site 696748005953 DNA interaction; other site 696748005954 Metal-binding active site; metal-binding site 696748005955 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 696748005956 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 696748005957 intersubunit interface [polypeptide binding]; other site 696748005958 active site 696748005959 Zn2+ binding site [ion binding]; other site 696748005960 hypothetical protein; Provisional; Region: PRK11018 696748005961 CPxP motif; other site 696748005962 putative inner membrane protein; Provisional; Region: PRK11099 696748005963 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 696748005964 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 696748005965 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 696748005966 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 696748005967 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 696748005968 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 696748005969 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 696748005970 Pirin-related protein [General function prediction only]; Region: COG1741 696748005971 Pirin; Region: Pirin; pfam02678 696748005972 Ferritin-like domain; Region: Ferritin; pfam00210 696748005973 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 696748005974 dimerization interface [polypeptide binding]; other site 696748005975 DPS ferroxidase diiron center [ion binding]; other site 696748005976 ion pore; other site 696748005977 PAS domain; Region: PAS_9; pfam13426 696748005978 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 696748005979 putative active site [active] 696748005980 heme pocket [chemical binding]; other site 696748005981 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 696748005982 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 696748005983 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 696748005984 FAD binding pocket [chemical binding]; other site 696748005985 conserved FAD binding motif [chemical binding]; other site 696748005986 phosphate binding motif [ion binding]; other site 696748005987 beta-alpha-beta structure motif; other site 696748005988 NAD binding pocket [chemical binding]; other site 696748005989 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 696748005990 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 696748005991 active site 696748005992 catalytic tetrad [active] 696748005993 lipoyl synthase; Provisional; Region: PRK05481 696748005994 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 696748005995 FeS/SAM binding site; other site 696748005996 lipoate-protein ligase B; Provisional; Region: PRK14342 696748005997 hypothetical protein; Provisional; Region: PRK04998 696748005998 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 696748005999 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 696748006000 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 696748006001 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 696748006002 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 696748006003 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 696748006004 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 696748006005 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 696748006006 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 696748006007 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 696748006008 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 696748006009 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 696748006010 non-specific DNA binding site [nucleotide binding]; other site 696748006011 salt bridge; other site 696748006012 sequence-specific DNA binding site [nucleotide binding]; other site 696748006013 Transcription initiation factor IIE; Region: TFIIE; smart00531 696748006014 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 696748006015 MutS domain I; Region: MutS_I; pfam01624 696748006016 MutS domain II; Region: MutS_II; pfam05188 696748006017 MutS domain III; Region: MutS_III; pfam05192 696748006018 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 696748006019 Walker A/P-loop; other site 696748006020 ATP binding site [chemical binding]; other site 696748006021 Q-loop/lid; other site 696748006022 ABC transporter signature motif; other site 696748006023 Walker B; other site 696748006024 D-loop; other site 696748006025 H-loop/switch region; other site 696748006026 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 696748006027 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 696748006028 Walker A/P-loop; other site 696748006029 ATP binding site [chemical binding]; other site 696748006030 Q-loop/lid; other site 696748006031 ABC transporter signature motif; other site 696748006032 Walker B; other site 696748006033 D-loop; other site 696748006034 H-loop/switch region; other site 696748006035 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 696748006036 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 696748006037 dimer interface [polypeptide binding]; other site 696748006038 conserved gate region; other site 696748006039 putative PBP binding loops; other site 696748006040 ABC-ATPase subunit interface; other site 696748006041 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 696748006042 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 696748006043 substrate binding pocket [chemical binding]; other site 696748006044 membrane-bound complex binding site; other site 696748006045 hinge residues; other site 696748006046 hypothetical protein; Provisional; Region: PRK01752 696748006047 SEC-C motif; Region: SEC-C; pfam02810 696748006048 SEC-C motif; Region: SEC-C; pfam02810 696748006049 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 696748006050 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 696748006051 substrate binding site [chemical binding]; other site 696748006052 dimer interface [polypeptide binding]; other site 696748006053 ATP binding site [chemical binding]; other site 696748006054 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 696748006055 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 696748006056 ligand binding site [chemical binding]; other site 696748006057 dimerization interface [polypeptide binding]; other site 696748006058 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 696748006059 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 696748006060 TM-ABC transporter signature motif; other site 696748006061 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 696748006062 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 696748006063 Walker A/P-loop; other site 696748006064 ATP binding site [chemical binding]; other site 696748006065 Q-loop/lid; other site 696748006066 ABC transporter signature motif; other site 696748006067 Walker B; other site 696748006068 D-loop; other site 696748006069 H-loop/switch region; other site 696748006070 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 696748006071 D-ribose pyranase; Provisional; Region: PRK11797 696748006072 transcriptional repressor RbsR; Provisional; Region: PRK10423 696748006073 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 696748006074 DNA binding site [nucleotide binding] 696748006075 domain linker motif; other site 696748006076 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 696748006077 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 696748006078 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 696748006079 DNA binding site [nucleotide binding] 696748006080 domain linker motif; other site 696748006081 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 696748006082 putative ligand binding site [chemical binding]; other site 696748006083 putative dimerization interface [polypeptide binding]; other site 696748006084 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 696748006085 AAA domain; Region: AAA_18; pfam13238 696748006086 ATP-binding site [chemical binding]; other site 696748006087 Gluconate-6-phosphate binding site [chemical binding]; other site 696748006088 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 696748006089 fructuronate transporter; Provisional; Region: PRK10034; cl15264 696748006090 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 696748006091 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 696748006092 active site 696748006093 active pocket/dimerization site; other site 696748006094 phosphorylation site [posttranslational modification] 696748006095 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 696748006096 active site 696748006097 phosphorylation site [posttranslational modification] 696748006098 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 696748006099 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 696748006100 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 696748006101 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 696748006102 active site 696748006103 motif I; other site 696748006104 motif II; other site 696748006105 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 696748006106 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 696748006107 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 696748006108 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 696748006109 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 696748006110 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 696748006111 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 696748006112 S-adenosylmethionine binding site [chemical binding]; other site 696748006113 F0F1 ATP synthase subunit I; Validated; Region: PRK06099 696748006114 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 696748006115 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 696748006116 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 696748006117 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 696748006118 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 696748006119 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 696748006120 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 696748006121 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 696748006122 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 696748006123 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 696748006124 beta subunit interaction interface [polypeptide binding]; other site 696748006125 Walker A motif; other site 696748006126 ATP binding site [chemical binding]; other site 696748006127 Walker B motif; other site 696748006128 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 696748006129 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 696748006130 core domain interface [polypeptide binding]; other site 696748006131 delta subunit interface [polypeptide binding]; other site 696748006132 epsilon subunit interface [polypeptide binding]; other site 696748006133 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 696748006134 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 696748006135 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 696748006136 alpha subunit interaction interface [polypeptide binding]; other site 696748006137 Walker A motif; other site 696748006138 ATP binding site [chemical binding]; other site 696748006139 Walker B motif; other site 696748006140 inhibitor binding site; inhibition site 696748006141 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 696748006142 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 696748006143 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 696748006144 gamma subunit interface [polypeptide binding]; other site 696748006145 epsilon subunit interface [polypeptide binding]; other site 696748006146 LBP interface [polypeptide binding]; other site 696748006147 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 696748006148 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 696748006149 Ligand binding site; other site 696748006150 metal-binding site 696748006151 DsrH like protein; Region: DsrH; cl17347 696748006152 sulfur relay protein TusC/DsrF; Region: sulf_tusC_dsrF; TIGR03010 696748006153 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 696748006154 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 696748006155 YheO-like PAS domain; Region: PAS_6; pfam08348 696748006156 HTH domain; Region: HTH_22; pfam13309 696748006157 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 696748006158 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 696748006159 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 696748006160 hypothetical protein; Provisional; Region: PRK02119 696748006161 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 696748006162 catalytic residues [active] 696748006163 hinge region; other site 696748006164 alpha helical domain; other site 696748006165 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 696748006166 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 696748006167 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 696748006168 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 696748006169 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 696748006170 FeS/SAM binding site; other site 696748006171 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 696748006172 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 696748006173 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 696748006174 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 696748006175 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 696748006176 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 696748006177 glutaminase active site [active] 696748006178 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 696748006179 dimer interface [polypeptide binding]; other site 696748006180 active site 696748006181 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 696748006182 dimer interface [polypeptide binding]; other site 696748006183 active site 696748006184 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 696748006185 transmembrane helices; other site 696748006186 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 696748006187 TrkA-C domain; Region: TrkA_C; pfam02080 696748006188 TrkA-C domain; Region: TrkA_C; pfam02080 696748006189 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 696748006190 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 696748006191 transmembrane helices; other site 696748006192 TrkA-C domain; Region: TrkA_C; pfam02080 696748006193 TrkA-C domain; Region: TrkA_C; pfam02080 696748006194 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 696748006195 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 696748006196 Transcriptional regulator [Transcription]; Region: LysR; COG0583 696748006197 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 696748006198 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 696748006199 dimerization interface [polypeptide binding]; other site 696748006200 putative effector binding pocket; other site 696748006201 ABC-type Co2+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CbiK; COG5266 696748006202 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 696748006203 cobalt transport protein CbiM; Validated; Region: PRK06265 696748006204 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 696748006205 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 696748006206 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 696748006207 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 696748006208 Walker A/P-loop; other site 696748006209 ATP binding site [chemical binding]; other site 696748006210 Q-loop/lid; other site 696748006211 ABC transporter signature motif; other site 696748006212 Walker B; other site 696748006213 D-loop; other site 696748006214 H-loop/switch region; other site 696748006215 Urea transporter; Region: UT; pfam03253 696748006216 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 696748006217 alpha-gamma subunit interface [polypeptide binding]; other site 696748006218 beta-gamma subunit interface [polypeptide binding]; other site 696748006219 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 696748006220 gamma-beta subunit interface [polypeptide binding]; other site 696748006221 alpha-beta subunit interface [polypeptide binding]; other site 696748006222 urease subunit alpha; Reviewed; Region: ureC; PRK13207 696748006223 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 696748006224 subunit interactions [polypeptide binding]; other site 696748006225 active site 696748006226 flap region; other site 696748006227 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 696748006228 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 696748006229 putative C-terminal domain interface [polypeptide binding]; other site 696748006230 putative GSH binding site (G-site) [chemical binding]; other site 696748006231 putative dimer interface [polypeptide binding]; other site 696748006232 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 696748006233 N-terminal domain interface [polypeptide binding]; other site 696748006234 dimer interface [polypeptide binding]; other site 696748006235 substrate binding pocket (H-site) [chemical binding]; other site 696748006236 potential frameshift: common BLAST hit: gi|386018934|ref|YP_005936958.1| DNA-damage-inducible protein D 696748006237 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 696748006238 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 696748006239 dimer interface [polypeptide binding]; other site 696748006240 catalytic residues [active] 696748006241 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 696748006242 UreF; Region: UreF; pfam01730 696748006243 urease accessory protein UreG; Region: ureG; TIGR00101 696748006244 UreD urease accessory protein; Region: UreD; cl00530 696748006245 Uncharacterized conserved protein [Function unknown]; Region: COG1359 696748006246 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 696748006247 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 696748006248 putative metal binding site [ion binding]; other site 696748006249 conserved hypothetical protein; Region: TIGR00743 696748006250 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 696748006251 Hemerythrin-like domain; Region: Hr-like; cd12108 696748006252 Fe binding site [ion binding]; other site 696748006253 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 696748006254 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 696748006255 NADP binding site [chemical binding]; other site 696748006256 homopentamer interface [polypeptide binding]; other site 696748006257 substrate binding site [chemical binding]; other site 696748006258 active site 696748006259 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 696748006260 active site 696748006261 catalytic residues [active] 696748006262 metal binding site [ion binding]; metal-binding site 696748006263 DNA protecting protein DprA; Region: dprA; TIGR00732 696748006264 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 696748006265 Predicted membrane protein [Function unknown]; Region: COG1297 696748006266 putative oligopeptide transporter, OPT family; Region: TIGR00733 696748006267 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 696748006268 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 696748006269 active site 696748006270 P-loop; other site 696748006271 phosphorylation site [posttranslational modification] 696748006272 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 696748006273 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 696748006274 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 696748006275 putative homodimer interface [polypeptide binding]; other site 696748006276 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 696748006277 heterodimer interface [polypeptide binding]; other site 696748006278 homodimer interface [polypeptide binding]; other site 696748006279 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 696748006280 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 696748006281 23S rRNA interface [nucleotide binding]; other site 696748006282 L7/L12 interface [polypeptide binding]; other site 696748006283 putative thiostrepton binding site; other site 696748006284 L25 interface [polypeptide binding]; other site 696748006285 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 696748006286 mRNA/rRNA interface [nucleotide binding]; other site 696748006287 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 696748006288 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 696748006289 dimer interface [polypeptide binding]; other site 696748006290 active site 696748006291 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 696748006292 active site 2 [active] 696748006293 active site 1 [active] 696748006294 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696748006295 3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831 696748006296 NAD(P) binding site [chemical binding]; other site 696748006297 active site 696748006298 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 696748006299 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 696748006300 dimer interface [polypeptide binding]; other site 696748006301 active site 696748006302 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243 696748006303 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK06816 696748006304 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 696748006305 dimer interface [polypeptide binding]; other site 696748006306 active site 696748006307 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 696748006308 Transposase IS200 like; Region: Y1_Tnp; cl00848 696748006309 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 696748006310 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 696748006311 Walker A/P-loop; other site 696748006312 ATP binding site [chemical binding]; other site 696748006313 Q-loop/lid; other site 696748006314 ABC transporter signature motif; other site 696748006315 Walker B; other site 696748006316 D-loop; other site 696748006317 H-loop/switch region; other site 696748006318 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 696748006319 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 696748006320 Phosphopantetheine attachment site; Region: PP-binding; cl09936 696748006321 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 696748006322 active site 696748006323 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 696748006324 Domain of unknown function (DUF4410); Region: DUF4410; pfam14366 696748006325 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 696748006326 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 696748006327 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 696748006328 putative acyl-acceptor binding pocket; other site 696748006329 Phosphopantetheine attachment site; Region: PP-binding; cl09936 696748006330 acyl carrier protein; Provisional; Region: PRK05350 696748006331 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 696748006332 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 696748006333 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 696748006334 acyl-activating enzyme (AAE) consensus motif; other site 696748006335 acyl-activating enzyme (AAE) consensus motif; other site 696748006336 AMP binding site [chemical binding]; other site 696748006337 active site 696748006338 CoA binding site [chemical binding]; other site 696748006339 Predicted membrane protein [Function unknown]; Region: COG4648 696748006340 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 696748006341 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 696748006342 acyl-activating enzyme (AAE) consensus motif; other site 696748006343 AMP binding site [chemical binding]; other site 696748006344 active site 696748006345 CoA binding site [chemical binding]; other site 696748006346 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 696748006347 active site 2 [active] 696748006348 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 696748006349 Ligand binding site; other site 696748006350 Putative Catalytic site; other site 696748006351 DXD motif; other site 696748006352 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 696748006353 putative acyl-acceptor binding pocket; other site 696748006354 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 696748006355 active site 696748006356 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 696748006357 Predicted exporter [General function prediction only]; Region: COG4258 696748006358 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 696748006359 23S rRNA interface [nucleotide binding]; other site 696748006360 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 696748006361 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 696748006362 core dimer interface [polypeptide binding]; other site 696748006363 peripheral dimer interface [polypeptide binding]; other site 696748006364 L10 interface [polypeptide binding]; other site 696748006365 L11 interface [polypeptide binding]; other site 696748006366 putative EF-Tu interaction site [polypeptide binding]; other site 696748006367 putative EF-G interaction site [polypeptide binding]; other site 696748006368 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 696748006369 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 696748006370 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 696748006371 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 696748006372 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 696748006373 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 696748006374 RPB3 interaction site [polypeptide binding]; other site 696748006375 RPB1 interaction site [polypeptide binding]; other site 696748006376 RPB11 interaction site [polypeptide binding]; other site 696748006377 RPB10 interaction site [polypeptide binding]; other site 696748006378 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 696748006379 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 696748006380 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 696748006381 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 696748006382 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 696748006383 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 696748006384 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 696748006385 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 696748006386 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 696748006387 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 696748006388 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 696748006389 DNA binding site [nucleotide binding] 696748006390 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 696748006391 sporadically distributed protein, TIGR04141 family; Region: TIGR04141 696748006392 sporadically distributed protein, TIGR04141 family; Region: TIGR04141 696748006393 sporadically distributed protein, TIGR04141 family; Region: TIGR04141 696748006394 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 696748006395 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 696748006396 active site 696748006397 metal binding site [ion binding]; metal-binding site 696748006398 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 696748006399 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 696748006400 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 696748006401 Mg chelatase-related protein; Region: TIGR00368 696748006402 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 696748006403 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 696748006404 Walker A motif; other site 696748006405 ATP binding site [chemical binding]; other site 696748006406 Walker B motif; other site 696748006407 arginine finger; other site 696748006408 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 696748006409 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 696748006410 Putative serine esterase (DUF676); Region: DUF676; pfam05057 696748006411 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 696748006412 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 696748006413 dimer interface [polypeptide binding]; other site 696748006414 tetramer interface [polypeptide binding]; other site 696748006415 PYR/PP interface [polypeptide binding]; other site 696748006416 TPP binding site [chemical binding]; other site 696748006417 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 696748006418 TPP-binding site; other site 696748006419 NnaC (CMP-NeuNAc synthetase) _like subfamily of SGNH_hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: NnaC_like; cd01841 696748006420 active site 696748006421 catalytic triad [active] 696748006422 oxyanion hole [active] 696748006423 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 696748006424 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 696748006425 putative active site cavity [active] 696748006426 N-acetylmannosamine kinase; Provisional; Region: PRK05082 696748006427 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 696748006428 nucleotide binding site [chemical binding]; other site 696748006429 N-acetylneuraminate lyase; Provisional; Region: PRK04147 696748006430 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 696748006431 inhibitor site; inhibition site 696748006432 active site 696748006433 dimer interface [polypeptide binding]; other site 696748006434 catalytic residue [active] 696748006435 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 696748006436 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 696748006437 active site 696748006438 trimer interface [polypeptide binding]; other site 696748006439 allosteric site; other site 696748006440 active site lid [active] 696748006441 hexamer (dimer of trimers) interface [polypeptide binding]; other site 696748006442 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 696748006443 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 696748006444 active site 696748006445 dimer interface [polypeptide binding]; other site 696748006446 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 696748006447 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 696748006448 inhibitor-cofactor binding pocket; inhibition site 696748006449 pyridoxal 5'-phosphate binding site [chemical binding]; other site 696748006450 catalytic residue [active] 696748006451 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase; Region: ECA_wecA; TIGR02380 696748006452 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 696748006453 Mg++ binding site [ion binding]; other site 696748006454 putative catalytic motif [active] 696748006455 substrate binding site [chemical binding]; other site 696748006456 Chain length determinant protein [Cell envelope biogenesis, outer membrane]; Region: WzzB; COG3765 696748006457 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 696748006458 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 696748006459 active site 696748006460 homodimer interface [polypeptide binding]; other site 696748006461 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 696748006462 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 696748006463 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 696748006464 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 696748006465 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 696748006466 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 696748006467 Coenzyme A binding pocket [chemical binding]; other site 696748006468 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 696748006469 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 696748006470 inhibitor-cofactor binding pocket; inhibition site 696748006471 pyridoxal 5'-phosphate binding site [chemical binding]; other site 696748006472 catalytic residue [active] 696748006473 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 696748006474 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 696748006475 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 696748006476 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 696748006477 FAD binding pocket [chemical binding]; other site 696748006478 FAD binding motif [chemical binding]; other site 696748006479 phosphate binding motif [ion binding]; other site 696748006480 beta-alpha-beta structure motif; other site 696748006481 NAD binding pocket [chemical binding]; other site 696748006482 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 696748006483 catalytic loop [active] 696748006484 iron binding site [ion binding]; other site 696748006485 hybrid cluster protein; Provisional; Region: PRK05290 696748006486 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 696748006487 ACS interaction site; other site 696748006488 CODH interaction site; other site 696748006489 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 696748006490 CODH interaction site; other site 696748006491 metal cluster binding site [ion binding]; other site 696748006492 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; cl07929 696748006493 putative common antigen polymerase; Provisional; Region: PRK02975 696748006494 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 696748006495 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 696748006496 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 696748006497 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 696748006498 active site 696748006499 Int/Topo IB signature motif; other site 696748006500 Transposase IS200 like; Region: Y1_Tnp; pfam01797 696748006501 outer membrane protein A; Reviewed; Region: PRK10808 696748006502 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 696748006503 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 696748006504 ligand binding site [chemical binding]; other site 696748006505 outer membrane protein A; Reviewed; Region: PRK10808 696748006506 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 696748006507 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 696748006508 ligand binding site [chemical binding]; other site 696748006509 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 696748006510 FAD binding domain; Region: FAD_binding_4; pfam01565 696748006511 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 696748006512 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 696748006513 CoenzymeA binding site [chemical binding]; other site 696748006514 subunit interaction site [polypeptide binding]; other site 696748006515 PHB binding site; other site 696748006516 Protein of unknown function, DUF606; Region: DUF606; pfam04657 696748006517 Protein of unknown function, DUF606; Region: DUF606; pfam04657 696748006518 Transcriptional regulator [Transcription]; Region: LysR; COG0583 696748006519 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 696748006520 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 696748006521 dimerization interface [polypeptide binding]; other site 696748006522 membrane protein insertase; Provisional; Region: PRK01318 696748006523 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 696748006524 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 696748006525 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 696748006526 trmE is a tRNA modification GTPase; Region: trmE; cd04164 696748006527 G1 box; other site 696748006528 GTP/Mg2+ binding site [chemical binding]; other site 696748006529 Switch I region; other site 696748006530 G2 box; other site 696748006531 Switch II region; other site 696748006532 G3 box; other site 696748006533 G4 box; other site 696748006534 G5 box; other site 696748006535 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 696748006536 FMN-binding protein MioC; Provisional; Region: PRK09004 696748006537 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 696748006538 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 696748006539 putative N- and C-terminal domain interface [polypeptide binding]; other site 696748006540 putative active site [active] 696748006541 putative xylulose binding site [chemical binding]; other site 696748006542 MgATP binding site [chemical binding]; other site 696748006543 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 696748006544 nucleotide binding site [chemical binding]; other site 696748006545 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 696748006546 TonB-dependent lactoferrin and transferrin receptors; Region: TonB-tbp-lbp; TIGR01776 696748006547 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 696748006548 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 696748006549 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 696748006550 Transferrin binding protein-like solute binding protein; Region: Lipoprotein_5; pfam01298 696748006551 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 696748006552 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 696748006553 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; pfam01618 696748006554 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 696748006555 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 696748006556 Membrane protein of unknown function (DUF340); Region: DUF340; cl01028 696748006557 Membrane protein of unknown function (DUF340); Region: DUF340; cl01028 696748006558 2,3-diketo-L-gulonate reductase; Provisional; Region: PRK13260 696748006559 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 696748006560 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 696748006561 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 696748006562 NADH(P)-binding; Region: NAD_binding_10; pfam13460 696748006563 NAD(P) binding site [chemical binding]; other site 696748006564 active site 696748006565 putative heme utilization radical SAM enzyme HutW; Region: rSAM_HutW; TIGR04107 696748006566 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 696748006567 FeS/SAM binding site; other site 696748006568 putative heme utilization carrier protein HutX; Region: HutX; TIGR04108 696748006569 glutathionine S-transferase; Provisional; Region: PRK10542 696748006570 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 696748006571 C-terminal domain interface [polypeptide binding]; other site 696748006572 GSH binding site (G-site) [chemical binding]; other site 696748006573 dimer interface [polypeptide binding]; other site 696748006574 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 696748006575 dimer interface [polypeptide binding]; other site 696748006576 N-terminal domain interface [polypeptide binding]; other site 696748006577 substrate binding pocket (H-site) [chemical binding]; other site 696748006578 diaminopimelate decarboxylase; Region: lysA; TIGR01048 696748006579 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 696748006580 active site 696748006581 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 696748006582 substrate binding site [chemical binding]; other site 696748006583 catalytic residues [active] 696748006584 dimer interface [polypeptide binding]; other site 696748006585 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; pfam13627 696748006586 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 696748006587 active site 696748006588 ATP binding site [chemical binding]; other site 696748006589 capsule biosynthesis phosphatase; Region: EcbF-BcbF; TIGR01689 696748006590 GT2_BcbE_like is likely involved in the biosynthesis of the polysaccharide capsule; Region: GT2_BcE_like; cd04183 696748006591 Ligand binding site; other site 696748006592 accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712 696748006593 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 696748006594 active site 696748006595 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 696748006596 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 696748006597 Protein of unknown function (DUF3184); Region: DUF3184; pfam11380 696748006598 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 696748006599 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 696748006600 polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010 696748006601 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 696748006602 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 696748006603 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 696748006604 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 696748006605 Walker A/P-loop; other site 696748006606 ATP binding site [chemical binding]; other site 696748006607 Q-loop/lid; other site 696748006608 ABC transporter signature motif; other site 696748006609 Walker B; other site 696748006610 D-loop; other site 696748006611 H-loop/switch region; other site 696748006612 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 696748006613 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 696748006614 Walker A/P-loop; other site 696748006615 ATP binding site [chemical binding]; other site 696748006616 Q-loop/lid; other site 696748006617 ABC transporter signature motif; other site 696748006618 Walker B; other site 696748006619 D-loop; other site 696748006620 H-loop/switch region; other site 696748006621 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 696748006622 Walker A/P-loop; other site 696748006623 ATP binding site [chemical binding]; other site 696748006624 Q-loop/lid; other site 696748006625 ABC transporter signature motif; other site 696748006626 Walker B; other site 696748006627 D-loop; other site 696748006628 H-loop/switch region; other site 696748006629 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 696748006630 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 696748006631 putative active site [active] 696748006632 substrate binding site [chemical binding]; other site 696748006633 putative cosubstrate binding site; other site 696748006634 catalytic site [active] 696748006635 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 696748006636 substrate binding site [chemical binding]; other site 696748006637 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 696748006638 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 696748006639 hypothetical protein; Provisional; Region: PRK11568 696748006640 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 696748006641 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 696748006642 Cation transport protein; Region: TrkH; cl17365 696748006643 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 696748006644 Flavodoxin domain; Region: Flavodoxin_5; cl17428 696748006645 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 696748006646 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 696748006647 Protein of unknown function, DUF417; Region: DUF417; cl01162 696748006648 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 696748006649 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 696748006650 Walker A motif; other site 696748006651 ATP binding site [chemical binding]; other site 696748006652 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 696748006653 Walker B motif; other site 696748006654 arginine finger; other site 696748006655 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 696748006656 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 696748006657 active site 696748006658 HslU subunit interaction site [polypeptide binding]; other site 696748006659 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 696748006660 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 696748006661 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 696748006662 putative metal binding site [ion binding]; other site 696748006663 adenine DNA glycosylase; Provisional; Region: PRK10880 696748006664 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 696748006665 minor groove reading motif; other site 696748006666 helix-hairpin-helix signature motif; other site 696748006667 substrate binding pocket [chemical binding]; other site 696748006668 active site 696748006669 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 696748006670 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 696748006671 DNA binding and oxoG recognition site [nucleotide binding] 696748006672 oxidative damage protection protein; Provisional; Region: PRK05408 696748006673 murein transglycosylase C; Provisional; Region: mltC; PRK11671 696748006674 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 696748006675 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 696748006676 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 696748006677 N-acetyl-D-glucosamine binding site [chemical binding]; other site 696748006678 catalytic residue [active] 696748006679 signal recognition particle protein; Provisional; Region: PRK10867 696748006680 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 696748006681 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 696748006682 P loop; other site 696748006683 GTP binding site [chemical binding]; other site 696748006684 Signal peptide binding domain; Region: SRP_SPB; pfam02978 696748006685 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 696748006686 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 696748006687 putative active site [active] 696748006688 Uncharacterized protein family (UPF0075); Region: UPF0075; pfam03702 696748006689 Major Facilitator Superfamily; Region: MFS_1; pfam07690 696748006690 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 696748006691 putative substrate translocation pore; other site 696748006692 CrcB-like protein; Region: CRCB; cl09114 696748006693 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 696748006694 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 696748006695 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 696748006696 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 696748006697 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 696748006698 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 696748006699 poxB regulator PoxA; Provisional; Region: PRK09350 696748006700 motif 1; other site 696748006701 dimer interface [polypeptide binding]; other site 696748006702 active site 696748006703 motif 2; other site 696748006704 motif 3; other site 696748006705 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 696748006706 L-aspartate oxidase; Provisional; Region: PRK06175 696748006707 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 696748006708 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 696748006709 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 696748006710 catalytic loop [active] 696748006711 iron binding site [ion binding]; other site 696748006712 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 696748006713 D-subunit interface [polypeptide binding]; other site 696748006714 Iron-sulfur protein interface; other site 696748006715 proximal quinone binding site [chemical binding]; other site 696748006716 distal quinone binding site [chemical binding]; other site 696748006717 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 696748006718 Iron-sulfur protein interface; other site 696748006719 proximal quinone binding site [chemical binding]; other site 696748006720 C-subunit interface; other site 696748006721 distal quinone binding site; other site 696748006722 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 696748006723 ferredoxin-type protein; Provisional; Region: PRK10194 696748006724 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 696748006725 NapD protein; Region: NapD; pfam03927 696748006726 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 696748006727 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 696748006728 [4Fe-4S] binding site [ion binding]; other site 696748006729 molybdopterin cofactor binding site; other site 696748006730 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 696748006731 molybdopterin cofactor binding site; other site 696748006732 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 696748006733 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 696748006734 4Fe-4S binding domain; Region: Fer4_5; pfam12801 696748006735 4Fe-4S binding domain; Region: Fer4_6; pfam12837 696748006736 Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; pfam03892 696748006737 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 696748006738 periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family; Region: napC_nirT; TIGR02161 696748006739 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 696748006740 FAD binding domain; Region: FAD_binding_4; pfam01565 696748006741 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 696748006742 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 696748006743 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 696748006744 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 696748006745 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 696748006746 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 696748006747 putative active site [active] 696748006748 putative FMN binding site [chemical binding]; other site 696748006749 putative substrate binding site [chemical binding]; other site 696748006750 putative catalytic residue [active] 696748006751 Protein of unknown function (DUF406); Region: DUF406; pfam04175 696748006752 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 696748006753 aromatic amino acid transport protein; Region: araaP; TIGR00837 696748006754 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 696748006755 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 696748006756 DNA binding residues [nucleotide binding] 696748006757 bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471 696748006758 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 696748006759 ATP-grasp domain; Region: ATP-grasp_4; cl17255 696748006760 ATP-grasp domain; Region: ATP-grasp_4; cl17255 696748006761 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 696748006762 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 696748006763 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 696748006764 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; cl01604 696748006765 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 696748006766 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 696748006767 putative active site [active] 696748006768 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 696748006769 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 696748006770 putative active site [active] 696748006771 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 696748006772 S17 interaction site [polypeptide binding]; other site 696748006773 S8 interaction site; other site 696748006774 16S rRNA interaction site [nucleotide binding]; other site 696748006775 streptomycin interaction site [chemical binding]; other site 696748006776 23S rRNA interaction site [nucleotide binding]; other site 696748006777 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 696748006778 30S ribosomal protein S7; Validated; Region: PRK05302 696748006779 elongation factor G; Reviewed; Region: PRK00007 696748006780 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 696748006781 G1 box; other site 696748006782 putative GEF interaction site [polypeptide binding]; other site 696748006783 GTP/Mg2+ binding site [chemical binding]; other site 696748006784 Switch I region; other site 696748006785 G2 box; other site 696748006786 G3 box; other site 696748006787 Switch II region; other site 696748006788 G4 box; other site 696748006789 G5 box; other site 696748006790 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 696748006791 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 696748006792 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 696748006793 elongation factor Tu; Reviewed; Region: PRK00049 696748006794 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 696748006795 G1 box; other site 696748006796 GEF interaction site [polypeptide binding]; other site 696748006797 GTP/Mg2+ binding site [chemical binding]; other site 696748006798 Switch I region; other site 696748006799 G2 box; other site 696748006800 G3 box; other site 696748006801 Switch II region; other site 696748006802 G4 box; other site 696748006803 G5 box; other site 696748006804 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 696748006805 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 696748006806 Antibiotic Binding Site [chemical binding]; other site 696748006807 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 696748006808 UbiA prenyltransferase family; Region: UbiA; pfam01040 696748006809 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 696748006810 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 696748006811 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 696748006812 homodimer interaction site [polypeptide binding]; other site 696748006813 cofactor binding site; other site 696748006814 Uncharacterized conserved protein [Function unknown]; Region: COG2968 696748006815 Protein of unknown function (DUF541); Region: SIMPL; cl01077 696748006816 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 696748006817 amphipathic channel; other site 696748006818 Asn-Pro-Ala signature motifs; other site 696748006819 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10737 696748006820 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 696748006821 threonine dehydratase; Reviewed; Region: PRK09224 696748006822 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 696748006823 tetramer interface [polypeptide binding]; other site 696748006824 pyridoxal 5'-phosphate binding site [chemical binding]; other site 696748006825 catalytic residue [active] 696748006826 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 696748006827 putative Ile/Val binding site [chemical binding]; other site 696748006828 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 696748006829 putative Ile/Val binding site [chemical binding]; other site 696748006830 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 696748006831 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 696748006832 active site 696748006833 substrate binding site [chemical binding]; other site 696748006834 metal binding site [ion binding]; metal-binding site 696748006835 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 696748006836 tetramer (dimer of dimers) interface [polypeptide binding]; other site 696748006837 active site 696748006838 dimer interface [polypeptide binding]; other site 696748006839 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 696748006840 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 696748006841 ligand binding site [chemical binding]; other site 696748006842 NAD binding site [chemical binding]; other site 696748006843 tetramer interface [polypeptide binding]; other site 696748006844 catalytic site [active] 696748006845 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 696748006846 L-serine binding site [chemical binding]; other site 696748006847 ACT domain interface; other site 696748006848 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 696748006849 intersubunit interface [polypeptide binding]; other site 696748006850 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 696748006851 metal binding site [ion binding]; metal-binding site 696748006852 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 696748006853 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 696748006854 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 696748006855 ribonuclease E; Reviewed; Region: rne; PRK10811 696748006856 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 696748006857 homodimer interface [polypeptide binding]; other site 696748006858 oligonucleotide binding site [chemical binding]; other site 696748006859 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 696748006860 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 696748006861 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 696748006862 HIGH motif; other site 696748006863 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 696748006864 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 696748006865 active site 696748006866 KMSKS motif; other site 696748006867 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 696748006868 tRNA binding surface [nucleotide binding]; other site 696748006869 anticodon binding site; other site 696748006870 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 696748006871 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 696748006872 Coenzyme A binding pocket [chemical binding]; other site 696748006873 DNA polymerase III subunit chi; Validated; Region: PRK05728 696748006874 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 696748006875 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 696748006876 trigger factor; Provisional; Region: tig; PRK01490 696748006877 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 696748006878 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 696748006879 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 696748006880 active site residue [active] 696748006881 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 696748006882 SecA binding site; other site 696748006883 Preprotein binding site; other site 696748006884 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 696748006885 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 696748006886 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 696748006887 serine acetyltransferase; Provisional; Region: cysE; PRK11132 696748006888 Serine acetyltransferase, N-terminal; Region: SATase_N; smart00971 696748006889 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 696748006890 trimer interface [polypeptide binding]; other site 696748006891 active site 696748006892 substrate binding site [chemical binding]; other site 696748006893 CoA binding site [chemical binding]; other site 696748006894 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 696748006895 Chain length determinant protein; Region: Wzz; pfam02706 696748006896 Chain length determinant protein [Cell envelope biogenesis, outer membrane]; Region: WzzB; COG3765 696748006897 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 696748006898 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 696748006899 putative trimer interface [polypeptide binding]; other site 696748006900 putative CoA binding site [chemical binding]; other site 696748006901 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 696748006902 NeuB family; Region: NeuB; pfam03102 696748006903 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 696748006904 NeuB binding interface [polypeptide binding]; other site 696748006905 putative substrate binding site [chemical binding]; other site 696748006906 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 696748006907 ligand binding site; other site 696748006908 tetramer interface; other site 696748006909 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 696748006910 active site 696748006911 catalytic triad [active] 696748006912 oxyanion hole [active] 696748006913 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 696748006914 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 696748006915 active site 696748006916 homodimer interface [polypeptide binding]; other site 696748006917 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 696748006918 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 696748006919 active site 696748006920 Glycosyltransferase family 52; Region: Glyco_transf_52; pfam07922 696748006921 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 696748006922 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 696748006923 active site 696748006924 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 696748006925 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 696748006926 putative ADP-binding pocket [chemical binding]; other site 696748006927 undecaprenyl-phosphate galactose phosphotransferase; Provisional; Region: PRK15204 696748006928 Bacterial sugar transferase; Region: Bac_transf; pfam02397 696748006929 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 696748006930 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 696748006931 NAD binding site [chemical binding]; other site 696748006932 substrate binding site [chemical binding]; other site 696748006933 homodimer interface [polypeptide binding]; other site 696748006934 active site 696748006935 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 696748006936 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 696748006937 substrate binding site; other site 696748006938 tetramer interface; other site 696748006939 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 696748006940 DNA primase; Validated; Region: dnaG; PRK05667 696748006941 CHC2 zinc finger; Region: zf-CHC2; pfam01807 696748006942 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 696748006943 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 696748006944 active site 696748006945 metal binding site [ion binding]; metal-binding site 696748006946 interdomain interaction site; other site 696748006947 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 696748006948 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 696748006949 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 696748006950 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 696748006951 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 696748006952 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 696748006953 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 696748006954 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 696748006955 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 696748006956 DNA binding residues [nucleotide binding] 696748006957 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 696748006958 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 696748006959 PhnA protein; Region: PhnA; pfam03831 696748006960 Haem-binding domain; Region: Haem_bd; pfam14376 696748006961 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 696748006962 hypothetical protein; Validated; Region: PRK05090 696748006963 YGGT family; Region: YGGT; pfam02325 696748006964 YGGT family; Region: YGGT; pfam02325 696748006965 hypothetical protein; Provisional; Region: PRK11702 696748006966 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 696748006967 S-adenosylmethionine binding site [chemical binding]; other site 696748006968 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 696748006969 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 696748006970 dimer interface [polypeptide binding]; other site 696748006971 active site 696748006972 CoA binding pocket [chemical binding]; other site 696748006973 putative phosphate acyltransferase; Provisional; Region: PRK05331 696748006974 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 696748006975 hypothetical protein; Provisional; Region: PRK11193 696748006976 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 696748006977 hypothetical protein; Provisional; Region: PRK11573 696748006978 Domain of unknown function DUF21; Region: DUF21; pfam01595 696748006979 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 696748006980 Transporter associated domain; Region: CorC_HlyC; smart01091 696748006981 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 696748006982 Na2 binding site [ion binding]; other site 696748006983 putative substrate binding site 1 [chemical binding]; other site 696748006984 Na binding site 1 [ion binding]; other site 696748006985 putative substrate binding site 2 [chemical binding]; other site 696748006986 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 696748006987 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 696748006988 active pocket/dimerization site; other site 696748006989 active site 696748006990 phosphorylation site [posttranslational modification] 696748006991 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 696748006992 active site 696748006993 phosphorylation site [posttranslational modification] 696748006994 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 696748006995 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 696748006996 hypothetical protein; Provisional; Region: PRK02913 696748006997 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 696748006998 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 696748006999 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 696748007000 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 696748007001 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 696748007002 HlyD family secretion protein; Region: HlyD_3; pfam13437 696748007003 A sub-family of peptidase C39 which contains Cyclolysin and Hemolysin processing peptidases. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine...; Region: Peptidase_C39_likeA; cd02417 696748007004 type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846 696748007005 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 696748007006 ATP-binding cassette domain of hemolysin B, subfamily C; Region: ABCC_Hemolysin; cd03252 696748007007 Walker A/P-loop; other site 696748007008 ATP binding site [chemical binding]; other site 696748007009 Q-loop/lid; other site 696748007010 ABC transporter signature motif; other site 696748007011 Walker B; other site 696748007012 D-loop; other site 696748007013 H-loop/switch region; other site 696748007014 RTX N-terminal domain; Region: RTX; pfam02382 696748007015 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 696748007016 RTX C-terminal domain; Region: RTX_C; pfam08339 696748007017 RTX toxin acyltransferase family; Region: HlyC; pfam02794 696748007018 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 696748007019 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 696748007020 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 696748007021 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 696748007022 dimer interface [polypeptide binding]; other site 696748007023 conserved gate region; other site 696748007024 putative PBP binding loops; other site 696748007025 ABC-ATPase subunit interface; other site 696748007026 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 696748007027 dimer interface [polypeptide binding]; other site 696748007028 conserved gate region; other site 696748007029 putative PBP binding loops; other site 696748007030 ABC-ATPase subunit interface; other site 696748007031 ferric transporter ATP-binding subunit; Provisional; Region: fbpC; PRK11432 696748007032 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 696748007033 Walker A/P-loop; other site 696748007034 ATP binding site [chemical binding]; other site 696748007035 Q-loop/lid; other site 696748007036 ABC transporter signature motif; other site 696748007037 Walker B; other site 696748007038 D-loop; other site 696748007039 H-loop/switch region; other site 696748007040 TOBE domain; Region: TOBE_2; pfam08402 696748007041 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 696748007042 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 696748007043 active site 696748007044 HIGH motif; other site 696748007045 dimer interface [polypeptide binding]; other site 696748007046 KMSKS motif; other site 696748007047 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 696748007048 RNA binding surface [nucleotide binding]; other site 696748007049 exoribonuclease R; Provisional; Region: PRK11642 696748007050 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 696748007051 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 696748007052 RNB domain; Region: RNB; pfam00773 696748007053 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 696748007054 RNA binding site [nucleotide binding]; other site 696748007055 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 696748007056 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 696748007057 catalytic residues [active] 696748007058 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 696748007059 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 696748007060 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 696748007061 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 696748007062 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 696748007063 dimerization interface [polypeptide binding]; other site 696748007064 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 696748007065 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 696748007066 catalytic triad [active] 696748007067 dimer interface [polypeptide binding]; other site 696748007068 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 696748007069 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 696748007070 AMP binding site [chemical binding]; other site 696748007071 metal binding site [ion binding]; metal-binding site 696748007072 active site 696748007073 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 696748007074 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 696748007075 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 696748007076 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 696748007077 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 696748007078 catalytic residues [active] 696748007079 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 696748007080 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 696748007081 FMN binding site [chemical binding]; other site 696748007082 substrate binding site [chemical binding]; other site 696748007083 putative catalytic residue [active] 696748007084 OsmC-like protein; Region: OsmC; pfam02566 696748007085 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 696748007086 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 696748007087 catalytic residues [active] 696748007088 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 696748007089 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 696748007090 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 696748007091 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 696748007092 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 696748007093 S-formylglutathione hydrolase; Region: PLN02442 696748007094 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 696748007095 putative S-transferase; Provisional; Region: PRK11752 696748007096 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 696748007097 C-terminal domain interface [polypeptide binding]; other site 696748007098 GSH binding site (G-site) [chemical binding]; other site 696748007099 dimer interface [polypeptide binding]; other site 696748007100 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 696748007101 dimer interface [polypeptide binding]; other site 696748007102 N-terminal domain interface [polypeptide binding]; other site 696748007103 active site 696748007104 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 696748007105 oligomeric interface; other site 696748007106 putative active site [active] 696748007107 homodimer interface [polypeptide binding]; other site 696748007108 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 696748007109 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 696748007110 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 696748007111 substrate binding site [chemical binding]; other site 696748007112 catalytic Zn binding site [ion binding]; other site 696748007113 NAD binding site [chemical binding]; other site 696748007114 structural Zn binding site [ion binding]; other site 696748007115 dimer interface [polypeptide binding]; other site 696748007116 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 696748007117 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 696748007118 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 696748007119 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 696748007120 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 696748007121 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 696748007122 Methyltransferase domain; Region: Methyltransf_26; pfam13659 696748007123 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 696748007124 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 696748007125 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 696748007126 Uncharacterized conserved protein [Function unknown]; Region: COG1801 696748007127 Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; cl00816 696748007128 oxaloacetate decarboxylase; Provisional; Region: PRK14040 696748007129 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 696748007130 active site 696748007131 catalytic residues [active] 696748007132 metal binding site [ion binding]; metal-binding site 696748007133 homodimer binding site [polypeptide binding]; other site 696748007134 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 696748007135 carboxyltransferase (CT) interaction site; other site 696748007136 biotinylation site [posttranslational modification]; other site 696748007137 oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919 696748007138 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 696748007139 Citrate transporter; Region: CitMHS; pfam03600 696748007140 transmembrane helices; other site 696748007141 L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228 696748007142 tartrate dehydratase subunit alpha; Validated; Region: PRK08230 696748007143 Transcriptional regulator [Transcription]; Region: LysR; COG0583 696748007144 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 696748007145 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 696748007146 dimerization interface [polypeptide binding]; other site 696748007147 Adenylation domain of kDNA ligases and similar proteins; Region: Adenylation_kDNA_ligase_like; cd07896 696748007148 DNA binding site [nucleotide binding] 696748007149 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 696748007150 active site 696748007151 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of kDNA ligase-like ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_kDNA_ligase_like; cd08041 696748007152 DNA binding site [nucleotide binding] 696748007153 DNA replication initiation factor; Validated; Region: PRK06893 696748007154 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 696748007155 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 696748007156 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 696748007157 Walker A/P-loop; other site 696748007158 ATP binding site [chemical binding]; other site 696748007159 Q-loop/lid; other site 696748007160 ABC transporter signature motif; other site 696748007161 Walker B; other site 696748007162 D-loop; other site 696748007163 H-loop/switch region; other site 696748007164 heme exporter protein CcmB; Region: ccmB; TIGR01190 696748007165 heme exporter protein CcmC; Region: ccmC; TIGR01191 696748007166 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 696748007167 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165 696748007168 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 696748007169 potential protein location (hypothetical protein ASU2_10965 [Actinobacillus suis H91-0380]) that overlaps RNA (tRNA-R) 696748007170 potential protein location (hypothetical protein ASU2_10965 [Actinobacillus suis H91-0380]) that overlaps RNA (tRNA-S) 696748007171 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 696748007172 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 696748007173 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 696748007174 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 696748007175 substrate binding pocket [chemical binding]; other site 696748007176 membrane-bound complex binding site; other site 696748007177 hinge residues; other site 696748007178 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 696748007179 N-acetyl-D-glucosamine binding site [chemical binding]; other site 696748007180 catalytic residue [active] 696748007181 outer membrane lipoprotein; Provisional; Region: PRK11023 696748007182 BON domain; Region: BON; pfam04972 696748007183 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 696748007184 dimer interface [polypeptide binding]; other site 696748007185 active site 696748007186 hypothetical protein; Reviewed; Region: PRK12497 696748007187 LppC putative lipoprotein; Region: LppC; pfam04348 696748007188 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 696748007189 putative ligand binding site [chemical binding]; other site 696748007190 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 696748007191 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 696748007192 putative SAM binding site [chemical binding]; other site 696748007193 putative homodimer interface [polypeptide binding]; other site 696748007194 Protein of unknown function, DUF462; Region: DUF462; pfam04315 696748007195 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 696748007196 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 696748007197 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 696748007198 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 696748007199 DsbD alpha interface [polypeptide binding]; other site 696748007200 catalytic residues [active] 696748007201 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 696748007202 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 696748007203 non-specific DNA binding site [nucleotide binding]; other site 696748007204 salt bridge; other site 696748007205 sequence-specific DNA binding site [nucleotide binding]; other site 696748007206 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 696748007207 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 696748007208 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 696748007209 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 696748007210 substrate binding site [chemical binding]; other site 696748007211 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 696748007212 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 696748007213 Walker A/P-loop; other site 696748007214 ATP binding site [chemical binding]; other site 696748007215 Q-loop/lid; other site 696748007216 ABC transporter signature motif; other site 696748007217 Walker B; other site 696748007218 D-loop; other site 696748007219 H-loop/switch region; other site 696748007220 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 696748007221 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 696748007222 substrate binding pocket [chemical binding]; other site 696748007223 membrane-bound complex binding site; other site 696748007224 hinge residues; other site 696748007225 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 696748007226 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 696748007227 dimer interface [polypeptide binding]; other site 696748007228 conserved gate region; other site 696748007229 putative PBP binding loops; other site 696748007230 ABC-ATPase subunit interface; other site 696748007231 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 696748007232 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 696748007233 dimer interface [polypeptide binding]; other site 696748007234 conserved gate region; other site 696748007235 putative PBP binding loops; other site 696748007236 ABC-ATPase subunit interface; other site 696748007237 tellurite resistance protein TehB; Provisional; Region: PRK12335 696748007238 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 696748007239 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 696748007240 S-adenosylmethionine binding site [chemical binding]; other site 696748007241 4-hydroxyphenylacetate 3-monooxygenase, reductase component; Region: HpaC; TIGR02296 696748007242 dsDNA-mimic protein; Reviewed; Region: PRK05094 696748007243 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 696748007244 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 696748007245 S-adenosylmethionine binding site [chemical binding]; other site 696748007246 Violaxanthin de-epoxidase (VDE); Region: VDE; cl06253 696748007247 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 696748007248 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 696748007249 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 696748007250 P loop; other site 696748007251 GTP binding site [chemical binding]; other site 696748007252 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 696748007253 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 696748007254 Walker A/P-loop; other site 696748007255 ATP binding site [chemical binding]; other site 696748007256 Q-loop/lid; other site 696748007257 ABC transporter signature motif; other site 696748007258 Walker B; other site 696748007259 D-loop; other site 696748007260 H-loop/switch region; other site 696748007261 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 696748007262 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 696748007263 Autotransporter beta-domain; Region: Autotransporter; pfam03797 696748007264 ribonuclease E; Reviewed; Region: rne; PRK10811 696748007265 Protein of unknown function (DUF560); Region: DUF560; pfam04575 696748007266 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 696748007267 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 696748007268 active site 696748007269 motif I; other site 696748007270 motif II; other site 696748007271 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 696748007272 motif II; other site 696748007273 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 696748007274 DNA utilization protein GntX; Provisional; Region: PRK11595 696748007275 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 696748007276 active site 696748007277 Transcriptional regulator [Transcription]; Region: LysR; COG0583 696748007278 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 696748007279 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 696748007280 putative effector binding pocket; other site 696748007281 dimerization interface [polypeptide binding]; other site 696748007282 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 696748007283 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 696748007284 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 696748007285 S-adenosylmethionine binding site [chemical binding]; other site 696748007286 DNA polymerase III subunit psi; Validated; Region: PRK06856 696748007287 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 696748007288 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 696748007289 Coenzyme A binding pocket [chemical binding]; other site 696748007290 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 696748007291 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 696748007292 ATP binding site [chemical binding]; other site 696748007293 Mg++ binding site [ion binding]; other site 696748007294 motif III; other site 696748007295 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 696748007296 nucleotide binding region [chemical binding]; other site 696748007297 ATP-binding site [chemical binding]; other site 696748007298 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 696748007299 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 696748007300 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 696748007301 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 696748007302 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 696748007303 peptide binding site [polypeptide binding]; other site 696748007304 Uncharacterized Staphylococcus aureus AldA1 (SACOL0154) aldehyde dehydrogenase-like; Region: ALDH_StaphAldA1; cd07117 696748007305 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 696748007306 NAD(P) binding site [chemical binding]; other site 696748007307 catalytic residues [active] 696748007308 Predicted membrane protein [Function unknown]; Region: COG1584 696748007309 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 696748007310 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 696748007311 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 696748007312 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 696748007313 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 696748007314 Walker A/P-loop; other site 696748007315 ATP binding site [chemical binding]; other site 696748007316 Q-loop/lid; other site 696748007317 ABC transporter signature motif; other site 696748007318 Walker B; other site 696748007319 D-loop; other site 696748007320 H-loop/switch region; other site 696748007321 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 696748007322 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 696748007323 siderophore binding site; other site 696748007324 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 696748007325 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 696748007326 ABC-ATPase subunit interface; other site 696748007327 dimer interface [polypeptide binding]; other site 696748007328 putative PBP binding regions; other site 696748007329 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 696748007330 ABC-ATPase subunit interface; other site 696748007331 dimer interface [polypeptide binding]; other site 696748007332 putative PBP binding regions; other site 696748007333 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 696748007334 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 696748007335 N-terminal plug; other site 696748007336 ligand-binding site [chemical binding]; other site 696748007337 Uncharacterized protein conserved in bacteria (DUF2322); Region: DUF2322; pfam10084 696748007338 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 696748007339 ATP binding site [chemical binding]; other site 696748007340 active site 696748007341 substrate binding site [chemical binding]; other site 696748007342 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 696748007343 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 696748007344 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 696748007345 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 696748007346 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 696748007347 NAD binding site [chemical binding]; other site 696748007348 dimerization interface [polypeptide binding]; other site 696748007349 product binding site; other site 696748007350 substrate binding site [chemical binding]; other site 696748007351 zinc binding site [ion binding]; other site 696748007352 catalytic residues [active] 696748007353 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 696748007354 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 696748007355 pyridoxal 5'-phosphate binding site [chemical binding]; other site 696748007356 homodimer interface [polypeptide binding]; other site 696748007357 catalytic residue [active] 696748007358 Transposase IS200 like; Region: Y1_Tnp; pfam01797 696748007359 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 696748007360 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 696748007361 active site 696748007362 motif I; other site 696748007363 motif II; other site 696748007364 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 696748007365 putative active site pocket [active] 696748007366 4-fold oligomerization interface [polypeptide binding]; other site 696748007367 metal binding residues [ion binding]; metal-binding site 696748007368 3-fold/trimer interface [polypeptide binding]; other site 696748007369 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 696748007370 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 696748007371 putative active site [active] 696748007372 oxyanion strand; other site 696748007373 catalytic triad [active] 696748007374 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 696748007375 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 696748007376 catalytic residues [active] 696748007377 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 696748007378 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 696748007379 substrate binding site [chemical binding]; other site 696748007380 glutamase interaction surface [polypeptide binding]; other site 696748007381 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 696748007382 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 696748007383 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 696748007384 metal binding site [ion binding]; metal-binding site 696748007385 hypothetical protein; Provisional; Region: PRK11212 696748007386 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 696748007387 active site 696748007388 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 696748007389 Part of AAA domain; Region: AAA_19; pfam13245 696748007390 Family description; Region: UvrD_C_2; pfam13538 696748007391 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 696748007392 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 696748007393 ligand binding site [chemical binding]; other site 696748007394 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 696748007395 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 696748007396 trimer interface [polypeptide binding]; other site 696748007397 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 696748007398 trimer interface [polypeptide binding]; other site 696748007399 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 696748007400 trimer interface [polypeptide binding]; other site 696748007401 YadA-like C-terminal region; Region: YadA; pfam03895 696748007402 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 696748007403 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 696748007404 FtsX-like permease family; Region: FtsX; pfam02687 696748007405 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 696748007406 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 696748007407 Walker A/P-loop; other site 696748007408 ATP binding site [chemical binding]; other site 696748007409 Q-loop/lid; other site 696748007410 ABC transporter signature motif; other site 696748007411 Walker B; other site 696748007412 D-loop; other site 696748007413 H-loop/switch region; other site 696748007414 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 696748007415 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 696748007416 FtsX-like permease family; Region: FtsX; pfam02687 696748007417 glycerate dehydrogenase; Provisional; Region: PRK06932 696748007418 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 696748007419 putative ligand binding site [chemical binding]; other site 696748007420 putative NAD binding site [chemical binding]; other site 696748007421 catalytic site [active] 696748007422 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 696748007423 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 696748007424 Fic/DOC family; Region: Fic; cl00960 696748007425 VbhA antitoxin and related proteins; Region: VbhA_like; cd11586 696748007426 FIC domain binding interface [polypeptide binding]; other site 696748007427 Uncharacterized conserved protein [Function unknown]; Region: COG2912 696748007428 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 696748007429 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 696748007430 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 696748007431 peptide chain release factor 1; Validated; Region: prfA; PRK00591 696748007432 This domain is found in peptide chain release factors; Region: PCRF; smart00937 696748007433 RF-1 domain; Region: RF-1; pfam00472