-- dump date 20140618_191554 -- class Genbank::misc_feature -- table misc_feature_note -- id note 649831000001 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 649831000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 649831000003 Walker A motif; other site 649831000004 ATP binding site [chemical binding]; other site 649831000005 Walker B motif; other site 649831000006 arginine finger; other site 649831000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 649831000008 DnaA box-binding interface [nucleotide binding]; other site 649831000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 649831000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 649831000011 putative DNA binding surface [nucleotide binding]; other site 649831000012 dimer interface [polypeptide binding]; other site 649831000013 beta-clamp/clamp loader binding surface; other site 649831000014 beta-clamp/translesion DNA polymerase binding surface; other site 649831000015 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 649831000016 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 649831000017 recombination protein F; Reviewed; Region: recF; PRK00064 649831000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 649831000019 Walker A/P-loop; other site 649831000020 ATP binding site [chemical binding]; other site 649831000021 Q-loop/lid; other site 649831000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649831000023 ABC transporter signature motif; other site 649831000024 Walker B; other site 649831000025 D-loop; other site 649831000026 H-loop/switch region; other site 649831000027 Protein of unknown function (DUF721); Region: DUF721; cl02324 649831000028 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 649831000029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831000030 Mg2+ binding site [ion binding]; other site 649831000031 G-X-G motif; other site 649831000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 649831000033 anchoring element; other site 649831000034 dimer interface [polypeptide binding]; other site 649831000035 ATP binding site [chemical binding]; other site 649831000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 649831000037 active site 649831000038 putative metal-binding site [ion binding]; other site 649831000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 649831000040 DNA gyrase subunit A; Validated; Region: PRK05560 649831000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 649831000042 CAP-like domain; other site 649831000043 active site 649831000044 primary dimer interface [polypeptide binding]; other site 649831000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 649831000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 649831000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 649831000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 649831000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 649831000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 649831000051 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 649831000052 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 649831000053 Domain of unknown function (DUF4279); Region: DUF4279; pfam14106 649831000054 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 649831000055 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 649831000056 Helix-turn-helix domain; Region: HTH_17; pfam12728 649831000057 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 649831000058 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649831000059 S-adenosylmethionine binding site [chemical binding]; other site 649831000060 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 649831000061 nudix motif; other site 649831000062 PA2301 is an uncharacterized Pseudomonas aeruginosa protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's...; Region: PA2301; cd04939 649831000063 putative deacylase active site [active] 649831000064 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 649831000065 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 649831000066 catalytic residues [active] 649831000067 Fe-S metabolism associated domain; Region: SufE; cl00951 649831000068 FOG: CBS domain [General function prediction only]; Region: COG0517 649831000069 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 649831000070 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 649831000071 active site 649831000072 catalytic triad [active] 649831000073 oxyanion hole [active] 649831000074 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 649831000075 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 649831000076 active site residue [active] 649831000077 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 649831000078 active site residue [active] 649831000079 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 649831000080 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 649831000081 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 649831000082 DNA binding residues [nucleotide binding] 649831000083 Putative zinc-finger; Region: zf-HC2; pfam13490 649831000084 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 649831000085 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649831000086 Walker A/P-loop; other site 649831000087 ATP binding site [chemical binding]; other site 649831000088 Q-loop/lid; other site 649831000089 ABC transporter signature motif; other site 649831000090 Walker B; other site 649831000091 D-loop; other site 649831000092 H-loop/switch region; other site 649831000093 VanZ like family; Region: VanZ; pfam04892 649831000094 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 649831000095 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831000096 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 649831000097 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 649831000098 ATP-grasp domain; Region: ATP-grasp_4; cl17255 649831000099 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 649831000100 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 649831000101 active site 649831000102 catalytic residues [active] 649831000103 metal binding site [ion binding]; metal-binding site 649831000104 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 649831000105 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 649831000106 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 649831000107 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 649831000108 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 649831000109 active site 649831000110 AAA ATPase domain; Region: AAA_16; pfam13191 649831000111 Predicted ATPase [General function prediction only]; Region: COG3903 649831000112 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 649831000113 MarR family; Region: MarR; pfam01047 649831000114 Uncharacterized conserved protein [Function unknown]; Region: COG2353 649831000115 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 649831000116 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 649831000117 sequence-specific DNA binding site [nucleotide binding]; other site 649831000118 salt bridge; other site 649831000119 Domain of unknown function (DUF397); Region: DUF397; pfam04149 649831000120 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 649831000121 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 649831000122 CDP-tyvelose 2-epimerase, extended (e) SDRs; Region: CDP_TE_SDR_e; cd05258 649831000123 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 649831000124 NAD binding site [chemical binding]; other site 649831000125 homotetramer interface [polypeptide binding]; other site 649831000126 homodimer interface [polypeptide binding]; other site 649831000127 active site 649831000128 substrate binding site [chemical binding]; other site 649831000129 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 649831000130 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 649831000131 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 649831000132 phosphopeptide binding site; other site 649831000133 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 649831000134 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 649831000135 phosphopeptide binding site; other site 649831000136 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 649831000137 active site 649831000138 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 649831000139 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 649831000140 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 649831000141 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 649831000142 Catalytic domain of Protein Kinases; Region: PKc; cd00180 649831000143 active site 649831000144 ATP binding site [chemical binding]; other site 649831000145 substrate binding site [chemical binding]; other site 649831000146 activation loop (A-loop); other site 649831000147 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 649831000148 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 649831000149 active site 649831000150 ATP binding site [chemical binding]; other site 649831000151 substrate binding site [chemical binding]; other site 649831000152 activation loop (A-loop); other site 649831000153 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 649831000154 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 649831000155 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 649831000156 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 649831000157 Cysteine-rich domain; Region: CCG; pfam02754 649831000158 Cysteine-rich domain; Region: CCG; pfam02754 649831000159 Uncharacterized protein family (UPF0233); Region: UPF0233; pfam06781 649831000160 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 649831000161 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 649831000162 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 649831000163 active site 649831000164 catalytic site [active] 649831000165 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 649831000166 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 649831000167 glutamine binding [chemical binding]; other site 649831000168 catalytic triad [active] 649831000169 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 649831000170 Domain of unknown function DUF21; Region: DUF21; pfam01595 649831000171 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 649831000172 Transporter associated domain; Region: CorC_HlyC; smart01091 649831000173 Domain of unknown function DUF21; Region: DUF21; pfam01595 649831000174 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 649831000175 FOG: CBS domain [General function prediction only]; Region: COG0517 649831000176 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 649831000177 SnoaL-like domain; Region: SnoaL_4; pfam13577 649831000178 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 649831000179 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831000180 Phosphotransferase enzyme family; Region: APH; pfam01636 649831000181 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 649831000182 substrate binding site [chemical binding]; other site 649831000183 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 649831000184 DNA binding site [nucleotide binding] 649831000185 active site 649831000186 Int/Topo IB signature motif; other site 649831000187 catalytic residues [active] 649831000188 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 649831000189 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 649831000190 trimer interface [polypeptide binding]; other site 649831000191 active site 649831000192 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 649831000193 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 649831000194 YCII-related domain; Region: YCII; cl00999 649831000195 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 649831000196 active site 649831000197 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 649831000198 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 649831000199 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 649831000200 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 649831000201 FAD binding site [chemical binding]; other site 649831000202 substrate binding site [chemical binding]; other site 649831000203 catalytic residues [active] 649831000204 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 649831000205 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 649831000206 catalytic core [active] 649831000207 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 649831000208 NmrA-like family; Region: NmrA; pfam05368 649831000209 NADP binding site [chemical binding]; other site 649831000210 Predicted transcriptional regulators [Transcription]; Region: COG1733 649831000211 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 649831000212 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 649831000213 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 649831000214 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 649831000215 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 649831000216 NHL repeat; Region: NHL; pfam01436 649831000217 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 649831000218 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 649831000219 E3 interaction surface; other site 649831000220 lipoyl attachment site [posttranslational modification]; other site 649831000221 e3 binding domain; Region: E3_binding; pfam02817 649831000222 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 649831000223 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 649831000224 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 649831000225 alpha subunit interface [polypeptide binding]; other site 649831000226 TPP binding site [chemical binding]; other site 649831000227 heterodimer interface [polypeptide binding]; other site 649831000228 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 649831000229 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 649831000230 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 649831000231 TPP-binding site [chemical binding]; other site 649831000232 tetramer interface [polypeptide binding]; other site 649831000233 heterodimer interface [polypeptide binding]; other site 649831000234 phosphorylation loop region [posttranslational modification] 649831000235 104 kDa microneme/rhoptry antigen; Provisional; Region: PTZ00449 649831000236 YfjP GTPase; Region: YfjP; cd11383 649831000237 G1 box; other site 649831000238 GTP/Mg2+ binding site [chemical binding]; other site 649831000239 Switch I region; other site 649831000240 G2 box; other site 649831000241 Switch II region; other site 649831000242 G3 box; other site 649831000243 G4 box; other site 649831000244 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 649831000245 G1 box; other site 649831000246 GTP/Mg2+ binding site [chemical binding]; other site 649831000247 G2 box; other site 649831000248 Switch I region; other site 649831000249 G3 box; other site 649831000250 Switch II region; other site 649831000251 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 649831000252 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 649831000253 nucleotide binding site [chemical binding]; other site 649831000254 NEF interaction site [polypeptide binding]; other site 649831000255 SBD interface [polypeptide binding]; other site 649831000256 heat shock protein GrpE; Provisional; Region: PRK14140 649831000257 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 649831000258 dimer interface [polypeptide binding]; other site 649831000259 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 649831000260 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 649831000261 HSP70 interaction site [polypeptide binding]; other site 649831000262 DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684 649831000263 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 649831000264 Zn binding sites [ion binding]; other site 649831000265 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 649831000266 dimer interface [polypeptide binding]; other site 649831000267 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 649831000268 DNA binding residues [nucleotide binding] 649831000269 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 649831000270 putative dimer interface [polypeptide binding]; other site 649831000271 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 649831000272 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 649831000273 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 649831000274 TrkA-C domain; Region: TrkA_C; pfam02080 649831000275 sugar efflux transporter B; Provisional; Region: PRK15011 649831000276 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831000277 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 649831000278 Clp amino terminal domain; Region: Clp_N; pfam02861 649831000279 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 649831000280 Walker A motif; other site 649831000281 ATP binding site [chemical binding]; other site 649831000282 Walker B motif; other site 649831000283 arginine finger; other site 649831000284 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 649831000285 Walker A motif; other site 649831000286 ATP binding site [chemical binding]; other site 649831000287 Walker B motif; other site 649831000288 arginine finger; other site 649831000289 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 649831000290 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 649831000291 dimerization interface [polypeptide binding]; other site 649831000292 putative DNA binding site [nucleotide binding]; other site 649831000293 putative Zn2+ binding site [ion binding]; other site 649831000294 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 649831000295 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 649831000296 polynucleotide kinase-phosphatase; Region: bacter_Pnkp; TIGR04075 649831000297 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 649831000298 active site 649831000299 metal binding site [ion binding]; metal-binding site 649831000300 RNA repair, ligase-Pnkp-associating, region of Hen1; Region: Hen1_L; pfam12623 649831000301 3' terminal RNA ribose 2'-O-methyltransferase Hen1; Region: bacter_Hen1; TIGR04074 649831000302 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 649831000303 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 649831000304 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 649831000305 active site 649831000306 intersubunit interface [polypeptide binding]; other site 649831000307 zinc binding site [ion binding]; other site 649831000308 Na+ binding site [ion binding]; other site 649831000309 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 649831000310 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 649831000311 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 649831000312 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 649831000313 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 649831000314 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 649831000315 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 649831000316 GDP-binding site [chemical binding]; other site 649831000317 ACT binding site; other site 649831000318 IMP binding site; other site 649831000319 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 649831000320 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 649831000321 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 649831000322 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 649831000323 SCP-2 sterol transfer family; Region: SCP2; pfam02036 649831000324 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 649831000325 dimerization interface [polypeptide binding]; other site 649831000326 putative DNA binding site [nucleotide binding]; other site 649831000327 putative Zn2+ binding site [ion binding]; other site 649831000328 H+ Antiporter protein; Region: 2A0121; TIGR00900 649831000329 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831000330 putative substrate translocation pore; other site 649831000331 adenylosuccinate lyase; Region: purB; TIGR00928 649831000332 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 649831000333 tetramer interface [polypeptide binding]; other site 649831000334 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 649831000335 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 649831000336 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 649831000337 dimerization interface [polypeptide binding]; other site 649831000338 Major Facilitator Superfamily; Region: MFS_1; pfam07690 649831000339 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 649831000340 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 649831000341 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 649831000342 putative active site [active] 649831000343 catalytic triad [active] 649831000344 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 649831000345 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 649831000346 dimerization interface [polypeptide binding]; other site 649831000347 ATP binding site [chemical binding]; other site 649831000348 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 649831000349 dimerization interface [polypeptide binding]; other site 649831000350 ATP binding site [chemical binding]; other site 649831000351 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 649831000352 amidophosphoribosyltransferase; Provisional; Region: PRK07847 649831000353 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 649831000354 active site 649831000355 tetramer interface [polypeptide binding]; other site 649831000356 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 649831000357 active site 649831000358 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 649831000359 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 649831000360 dimerization interface [polypeptide binding]; other site 649831000361 putative ATP binding site [chemical binding]; other site 649831000362 radical SAM/SPASM domain protein, GRRM system; Region: rSAM_GlyRichRpt; TIGR04261 649831000363 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 649831000364 FeS/SAM binding site; other site 649831000365 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 649831000366 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 649831000367 DNA binding residues [nucleotide binding] 649831000368 Second Helix-Turn-Helix DNA binding domain of the regulatory protein TioE; Region: HTH_TioE_rpt2; cd04773 649831000369 DNA binding residues [nucleotide binding] 649831000370 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 649831000371 putative dimer interface [polypeptide binding]; other site 649831000372 Erythromycin esterase; Region: Erythro_esteras; pfam05139 649831000373 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 649831000374 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 649831000375 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 649831000376 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 649831000377 NAD binding site [chemical binding]; other site 649831000378 Phe binding site; other site 649831000379 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 649831000380 DNA binding residues [nucleotide binding] 649831000381 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649831000382 S-adenosylmethionine binding site [chemical binding]; other site 649831000383 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 649831000384 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 649831000385 Protease prsW family; Region: PrsW-protease; pfam13367 649831000386 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 649831000387 CoenzymeA binding site [chemical binding]; other site 649831000388 subunit interaction site [polypeptide binding]; other site 649831000389 PHB binding site; other site 649831000390 SGNH_hydrolase subfamily, similar to Ruminococcus flavefaciens XynB. Most likely a secreted hydrolase with xylanase activity. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from...; Region: XynB_like; cd01833 649831000391 active site 649831000392 catalytic triad [active] 649831000393 oxyanion hole [active] 649831000394 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 649831000395 anti sigma factor interaction site; other site 649831000396 regulatory phosphorylation site [posttranslational modification]; other site 649831000397 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 649831000398 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 649831000399 ATP binding site [chemical binding]; other site 649831000400 Mg2+ binding site [ion binding]; other site 649831000401 G-X-G motif; other site 649831000402 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 649831000403 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 649831000404 hypothetical protein; Provisional; Region: PRK08244 649831000405 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 649831000406 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 649831000407 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 649831000408 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 649831000409 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 649831000410 active site 649831000411 DNA binding site [nucleotide binding] 649831000412 Int/Topo IB signature motif; other site 649831000413 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 649831000414 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 649831000415 DNA binding residues [nucleotide binding] 649831000416 B12 binding domain; Region: B12-binding_2; pfam02607 649831000417 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 649831000418 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 649831000419 active site 649831000420 metal binding site [ion binding]; metal-binding site 649831000421 nudix motif; other site 649831000422 phytoene desaturase; Region: crtI_fam; TIGR02734 649831000423 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 649831000424 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 649831000425 substrate binding pocket [chemical binding]; other site 649831000426 chain length determination region; other site 649831000427 substrate-Mg2+ binding site; other site 649831000428 catalytic residues [active] 649831000429 aspartate-rich region 1; other site 649831000430 active site lid residues [active] 649831000431 aspartate-rich region 2; other site 649831000432 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 649831000433 catalytic residues [active] 649831000434 substrate binding pocket [chemical binding]; other site 649831000435 substrate-Mg2+ binding site; other site 649831000436 aspartate-rich region 1; other site 649831000437 aspartate-rich region 2; other site 649831000438 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 649831000439 DNA photolyase; Region: DNA_photolyase; pfam00875 649831000440 Beta-lactamase; Region: Beta-lactamase; pfam00144 649831000441 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 649831000442 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 649831000443 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 649831000444 ATP binding site [chemical binding]; other site 649831000445 Mg2+ binding site [ion binding]; other site 649831000446 G-X-G motif; other site 649831000447 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 649831000448 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 649831000449 iron-sulfur cluster [ion binding]; other site 649831000450 [2Fe-2S] cluster binding site [ion binding]; other site 649831000451 FAD binding domain; Region: FAD_binding_4; pfam01565 649831000452 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 649831000453 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 649831000454 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 649831000455 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 649831000456 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 649831000457 Walker A/P-loop; other site 649831000458 ATP binding site [chemical binding]; other site 649831000459 Q-loop/lid; other site 649831000460 ABC transporter signature motif; other site 649831000461 Walker B; other site 649831000462 D-loop; other site 649831000463 H-loop/switch region; other site 649831000464 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649831000465 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831000466 active site 649831000467 phosphorylation site [posttranslational modification] 649831000468 intermolecular recognition site; other site 649831000469 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649831000470 DNA binding residues [nucleotide binding] 649831000471 Putative sensor; Region: Sensor; pfam13796 649831000472 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 649831000473 Histidine kinase; Region: HisKA_3; pfam07730 649831000474 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 649831000475 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 649831000476 MoxR-like ATPases [General function prediction only]; Region: COG0714 649831000477 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 649831000478 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 649831000479 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 649831000480 metal ion-dependent adhesion site (MIDAS); other site 649831000481 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 649831000482 Right handed beta helix region; Region: Beta_helix; pfam13229 649831000483 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 649831000484 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 649831000485 active site 649831000486 ATP binding site [chemical binding]; other site 649831000487 substrate binding site [chemical binding]; other site 649831000488 activation loop (A-loop); other site 649831000489 Bulb-type mannose-specific lectin; Region: B_lectin; smart00108 649831000490 Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028 649831000491 dimerization interface [polypeptide binding]; other site 649831000492 mannose binding site [chemical binding]; other site 649831000493 TIGR02594 family protein; Region: TIGR02594 649831000494 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 649831000495 Transposase; Region: DDE_Tnp_ISL3; pfam01610 649831000496 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 649831000497 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 649831000498 non-specific DNA binding site [nucleotide binding]; other site 649831000499 salt bridge; other site 649831000500 sequence-specific DNA binding site [nucleotide binding]; other site 649831000501 Domain of unknown function (DUF955); Region: DUF955; cl01076 649831000502 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 649831000503 DEAD/DEAH box helicase; Region: DEAD; pfam00270 649831000504 ATP binding site [chemical binding]; other site 649831000505 Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271 649831000506 ATP-binding site [chemical binding]; other site 649831000507 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 649831000508 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 649831000509 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 649831000510 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 649831000511 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 649831000512 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 649831000513 cofactor binding site; other site 649831000514 DNA binding site [nucleotide binding] 649831000515 substrate interaction site [chemical binding]; other site 649831000516 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 649831000517 Divergent AAA domain; Region: AAA_4; pfam04326 649831000518 Recombination endonuclease VII; Region: Endonuclease_7; pfam02945 649831000519 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 649831000520 RHS Repeat; Region: RHS_repeat; cl11982 649831000521 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 649831000522 Bacterial transcriptional activator domain; Region: BTAD; smart01043 649831000523 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 649831000524 classical (c) SDRs; Region: SDR_c; cd05233 649831000525 short chain dehydrogenase; Provisional; Region: PRK07041 649831000526 NAD(P) binding site [chemical binding]; other site 649831000527 active site 649831000528 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831000529 NAD(P) binding site [chemical binding]; other site 649831000530 active site 649831000531 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 649831000532 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 649831000533 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 649831000534 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831000535 Bacterial transcriptional activator domain; Region: BTAD; smart01043 649831000536 Thioesterase domain; Region: Thioesterase; pfam00975 649831000537 Cupin domain; Region: Cupin_2; cl17218 649831000538 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: Php; COG1735 649831000539 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 649831000540 FAD binding domain; Region: FAD_binding_4; pfam01565 649831000541 Berberine and berberine like; Region: BBE; pfam08031 649831000542 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 649831000543 salt bridge; other site 649831000544 non-specific DNA binding site [nucleotide binding]; other site 649831000545 sequence-specific DNA binding site [nucleotide binding]; other site 649831000546 A-factor biosynthesis hotdog domain; Region: AfsA; pfam03756 649831000547 A-factor biosynthesis hotdog domain; Region: AfsA; pfam03756 649831000548 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 649831000549 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 649831000550 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 649831000551 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 649831000552 dimer interface [polypeptide binding]; other site 649831000553 active site 649831000554 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831000555 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 649831000556 NAD(P) binding site [chemical binding]; other site 649831000557 active site 649831000558 hypothetical protein; Provisional; Region: PRK06184 649831000559 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 649831000560 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 649831000561 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 649831000562 active site 649831000563 catalytic tetrad [active] 649831000564 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 649831000565 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 649831000566 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 649831000567 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831000568 active site 649831000569 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 649831000570 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 649831000571 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831000572 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 649831000573 Enoylreductase; Region: PKS_ER; smart00829 649831000574 NAD(P) binding site [chemical binding]; other site 649831000575 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 649831000576 putative NADP binding site [chemical binding]; other site 649831000577 KR domain; Region: KR; pfam08659 649831000578 active site 649831000579 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831000580 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831000581 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 649831000582 active site 649831000583 Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631 649831000584 prolyl-tRNA synthetase; Provisional; Region: PRK09194 649831000585 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 649831000586 dimer interface [polypeptide binding]; other site 649831000587 motif 1; other site 649831000588 active site 649831000589 motif 2; other site 649831000590 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 649831000591 putative deacylase active site [active] 649831000592 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 649831000593 active site 649831000594 motif 3; other site 649831000595 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 649831000596 anticodon binding site; other site 649831000597 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 649831000598 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 649831000599 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649831000600 Walker A/P-loop; other site 649831000601 ATP binding site [chemical binding]; other site 649831000602 Q-loop/lid; other site 649831000603 ABC transporter signature motif; other site 649831000604 Walker B; other site 649831000605 D-loop; other site 649831000606 H-loop/switch region; other site 649831000607 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 649831000608 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 649831000609 YcaO-like family; Region: YcaO; pfam02624 649831000610 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 649831000611 Catalytic domain of Protein Kinases; Region: PKc; cd00180 649831000612 active site 649831000613 ATP binding site [chemical binding]; other site 649831000614 substrate binding site [chemical binding]; other site 649831000615 activation loop (A-loop); other site 649831000616 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 649831000617 active site 649831000618 zinc binding site [ion binding]; other site 649831000619 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 649831000620 active site 649831000621 putative substrate binding region [chemical binding]; other site 649831000622 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 649831000623 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 649831000624 active site 649831000625 NAD binding site [chemical binding]; other site 649831000626 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 649831000627 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 649831000628 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 649831000629 catalytic residue [active] 649831000630 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649831000631 S-adenosylmethionine binding site [chemical binding]; other site 649831000632 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 649831000633 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649831000634 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649831000635 DNA binding residues [nucleotide binding] 649831000636 dimerization interface [polypeptide binding]; other site 649831000637 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 649831000638 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 649831000639 acyl-activating enzyme (AAE) consensus motif; other site 649831000640 AMP binding site [chemical binding]; other site 649831000641 active site 649831000642 CoA binding site [chemical binding]; other site 649831000643 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 649831000644 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831000645 active site 649831000646 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 649831000647 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 649831000648 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 649831000649 putative NADP binding site [chemical binding]; other site 649831000650 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 649831000651 active site 649831000652 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831000653 Thioesterase; Region: PKS_TE; smart00824 649831000654 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 649831000655 metal ion-dependent adhesion site (MIDAS); other site 649831000656 von Willebrand factor type A domain; Region: VWA_2; pfam13519 649831000657 metal ion-dependent adhesion site (MIDAS); other site 649831000658 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 649831000659 Protein of unknown function DUF58; Region: DUF58; pfam01882 649831000660 MoxR-like ATPases [General function prediction only]; Region: COG0714 649831000661 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 649831000662 Walker A motif; other site 649831000663 ATP binding site [chemical binding]; other site 649831000664 Walker B motif; other site 649831000665 arginine finger; other site 649831000666 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 649831000667 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 649831000668 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 649831000669 DNA binding residues [nucleotide binding] 649831000670 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 649831000671 Phosphoesterase family; Region: Phosphoesterase; pfam04185 649831000672 Domain of unknown function (DUF756); Region: DUF756; pfam05506 649831000673 Domain of unknown function (DUF756); Region: DUF756; pfam05506 649831000674 transcription termination factor Rho; Provisional; Region: PRK12608 649831000675 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 649831000676 RNA binding site [nucleotide binding]; other site 649831000677 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 649831000678 Walker A motif; other site 649831000679 ATP binding site [chemical binding]; other site 649831000680 Walker B motif; other site 649831000681 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 649831000682 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 649831000683 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 649831000684 catalytic residue [active] 649831000685 NACHT domain; Region: NACHT; pfam05729 649831000686 FOG: WD40 repeat [General function prediction only]; Region: COG2319 649831000687 FOG: WD40 repeat [General function prediction only]; Region: COG2319 649831000688 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 649831000689 structural tetrad; other site 649831000690 Response regulator receiver domain; Region: Response_reg; pfam00072 649831000691 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831000692 active site 649831000693 phosphorylation site [posttranslational modification] 649831000694 intermolecular recognition site; other site 649831000695 dimerization interface [polypeptide binding]; other site 649831000696 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 649831000697 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 649831000698 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 649831000699 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 649831000700 dimer interface [polypeptide binding]; other site 649831000701 phosphorylation site [posttranslational modification] 649831000702 S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711 649831000703 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831000704 ATP binding site [chemical binding]; other site 649831000705 Mg2+ binding site [ion binding]; other site 649831000706 G-X-G motif; other site 649831000707 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 649831000708 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 649831000709 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 649831000710 RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361 649831000711 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 649831000712 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 649831000713 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 649831000714 anti sigma factor interaction site; other site 649831000715 regulatory phosphorylation site [posttranslational modification]; other site 649831000716 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 649831000717 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 649831000718 Putative zinc-finger; Region: zf-HC2; pfam13490 649831000719 Predicted integral membrane protein [Function unknown]; Region: COG5660 649831000720 CGNR zinc finger; Region: zf-CGNR; pfam11706 649831000721 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 649831000722 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 649831000723 TIGR03086 family protein; Region: TIGR03086 649831000724 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 649831000725 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 649831000726 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 649831000727 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 649831000728 FAD binding domain; Region: FAD_binding_4; pfam01565 649831000729 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 649831000730 MarR family; Region: MarR_2; pfam12802 649831000731 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 649831000732 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831000733 NAD(P) binding site [chemical binding]; other site 649831000734 active site 649831000735 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 649831000736 RibD C-terminal domain; Region: RibD_C; cl17279 649831000737 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 649831000738 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 649831000739 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 649831000740 ATP binding site [chemical binding]; other site 649831000741 Mg2+ binding site [ion binding]; other site 649831000742 G-X-G motif; other site 649831000743 GAF domain; Region: GAF; cl17456 649831000744 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 649831000745 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 649831000746 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 649831000747 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 649831000748 dimerization interface [polypeptide binding]; other site 649831000749 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 649831000750 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 649831000751 dimerization interface [polypeptide binding]; other site 649831000752 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 649831000753 dimerization interface [polypeptide binding]; other site 649831000754 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 649831000755 dimerization interface [polypeptide binding]; other site 649831000756 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 649831000757 dimerization interface [polypeptide binding]; other site 649831000758 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 649831000759 dimerization interface [polypeptide binding]; other site 649831000760 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 649831000761 dimerization interface [polypeptide binding]; other site 649831000762 GAF domain; Region: GAF_2; pfam13185 649831000763 GAF domain; Region: GAF; pfam01590 649831000764 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 649831000765 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831000766 ATP binding site [chemical binding]; other site 649831000767 Mg2+ binding site [ion binding]; other site 649831000768 G-X-G motif; other site 649831000769 Response regulator receiver domain; Region: Response_reg; pfam00072 649831000770 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831000771 active site 649831000772 phosphorylation site [posttranslational modification] 649831000773 intermolecular recognition site; other site 649831000774 dimerization interface [polypeptide binding]; other site 649831000775 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831000776 Response regulator receiver domain; Region: Response_reg; pfam00072 649831000777 active site 649831000778 phosphorylation site [posttranslational modification] 649831000779 intermolecular recognition site; other site 649831000780 dimerization interface [polypeptide binding]; other site 649831000781 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 649831000782 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 649831000783 NAD(P) binding site [chemical binding]; other site 649831000784 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 649831000785 anti sigma factor interaction site; other site 649831000786 regulatory phosphorylation site [posttranslational modification]; other site 649831000787 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 649831000788 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 649831000789 inhibitor-cofactor binding pocket; inhibition site 649831000790 pyridoxal 5'-phosphate binding site [chemical binding]; other site 649831000791 catalytic residue [active] 649831000792 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 649831000793 catalytic core [active] 649831000794 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 649831000795 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 649831000796 catalytic residues [active] 649831000797 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 649831000798 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 649831000799 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 649831000800 ResB-like family; Region: ResB; pfam05140 649831000801 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 649831000802 Predicted transcriptional regulators [Transcription]; Region: COG1733 649831000803 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 649831000804 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 649831000805 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 649831000806 menaquinone biosynthesis decarboxylase, SCO4490 family; Region: mena_SCO4490; TIGR03701 649831000807 prenyltransferase; Reviewed; Region: ubiA; PRK12888 649831000808 UbiA prenyltransferase family; Region: UbiA; pfam01040 649831000809 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 649831000810 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 649831000811 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 649831000812 DNA binding residues [nucleotide binding] 649831000813 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 649831000814 Flavoprotein; Region: Flavoprotein; pfam02441 649831000815 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 649831000816 DNA binding residues [nucleotide binding] 649831000817 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 649831000818 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 649831000819 putative DNA binding site [nucleotide binding]; other site 649831000820 putative Zn2+ binding site [ion binding]; other site 649831000821 AsnC family; Region: AsnC_trans_reg; pfam01037 649831000822 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 649831000823 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 649831000824 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 649831000825 catalytic residue [active] 649831000826 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 649831000827 Putative glycolipid-binding; Region: Glycolipid_bind; cl01425 649831000828 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 649831000829 DEAD-like helicases superfamily; Region: DEXDc; smart00487 649831000830 ATP binding site [chemical binding]; other site 649831000831 Mg++ binding site [ion binding]; other site 649831000832 motif III; other site 649831000833 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 649831000834 nucleotide binding region [chemical binding]; other site 649831000835 ATP-binding site [chemical binding]; other site 649831000836 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 649831000837 non-specific DNA binding site [nucleotide binding]; other site 649831000838 salt bridge; other site 649831000839 sequence-specific DNA binding site [nucleotide binding]; other site 649831000840 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 649831000841 polymerase nucleotide-binding site; other site 649831000842 DNA-binding residues [nucleotide binding]; DNA binding site 649831000843 nucleotide binding site [chemical binding]; other site 649831000844 primase nucleotide-binding site [nucleotide binding]; other site 649831000845 D5 N terminal like; Region: D5_N; pfam08706 649831000846 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 649831000847 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 649831000848 HNH endonuclease; Region: HNH_3; pfam13392 649831000849 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 649831000850 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 649831000851 Phage capsid family; Region: Phage_capsid; pfam05065 649831000852 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 649831000853 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 649831000854 N-acetylmuramoyl-L-alanine amidase; Region: Amidase_2; pfam01510 649831000855 amidase catalytic site [active] 649831000856 Zn binding residues [ion binding]; other site 649831000857 substrate binding site [chemical binding]; other site 649831000858 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 649831000859 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 649831000860 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 649831000861 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 649831000862 active site 649831000863 catalytic residues [active] 649831000864 DNA binding site [nucleotide binding] 649831000865 Int/Topo IB signature motif; other site 649831000866 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 649831000867 NlpC/P60 family; Region: NLPC_P60; pfam00877 649831000868 putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700 649831000869 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 649831000870 FeS/SAM binding site; other site 649831000871 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 649831000872 Peptidase M14 Carboxypeptidase T subfamily; Region: M14_CPT; cd03859 649831000873 putative active site [active] 649831000874 Zn binding site [ion binding]; other site 649831000875 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 649831000876 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 649831000877 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 649831000878 Part of AAA domain; Region: AAA_19; pfam13245 649831000879 Family description; Region: UvrD_C_2; pfam13538 649831000880 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 649831000881 putative DNA binding site [nucleotide binding]; other site 649831000882 dimerization interface [polypeptide binding]; other site 649831000883 putative Zn2+ binding site [ion binding]; other site 649831000884 Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621 649831000885 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 649831000886 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 649831000887 active site 649831000888 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 649831000889 Putative Catalytic site; other site 649831000890 DXD motif; other site 649831000891 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 649831000892 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 649831000893 active site 649831000894 catalytic tetrad [active] 649831000895 glycoside hydrolase family 64: laminaripentaose-producing, beta-1,3-glucanase (LPHase)-like; Region: GH64-LPHase-like; cd09216 649831000896 substrate binding pocket [chemical binding]; other site 649831000897 catalytic residues [active] 649831000898 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 649831000899 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 649831000900 putative sugar binding sites [chemical binding]; other site 649831000901 Q-X-W motif; other site 649831000902 Uncharacterized conserved protein [Function unknown]; Region: COG4279 649831000903 SWIM zinc finger; Region: SWIM; pfam04434 649831000904 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 649831000905 SNF2 Helicase protein; Region: DUF3670; pfam12419 649831000906 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 649831000907 ATP binding site [chemical binding]; other site 649831000908 putative Mg++ binding site [ion binding]; other site 649831000909 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 649831000910 nucleotide binding region [chemical binding]; other site 649831000911 ATP-binding site [chemical binding]; other site 649831000912 menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699 649831000913 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 649831000914 FeS/SAM binding site; other site 649831000915 Domain of unknown function (DUF3557); Region: DUF3557; pfam12078 649831000916 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 649831000917 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649831000918 S-adenosylmethionine binding site [chemical binding]; other site 649831000919 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 649831000920 NADH dehydrogenase subunit A; Validated; Region: PRK07928 649831000921 NADH dehydrogenase subunit B; Validated; Region: PRK06411 649831000922 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 649831000923 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 649831000924 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 649831000925 NADH dehydrogenase subunit D; Validated; Region: PRK06075 649831000926 NADH dehydrogenase subunit E; Validated; Region: PRK07539 649831000927 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 649831000928 putative dimer interface [polypeptide binding]; other site 649831000929 [2Fe-2S] cluster binding site [ion binding]; other site 649831000930 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 649831000931 SLBB domain; Region: SLBB; pfam10531 649831000932 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 649831000933 NADH dehydrogenase subunit G; Validated; Region: PRK07860 649831000934 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 649831000935 catalytic loop [active] 649831000936 iron binding site [ion binding]; other site 649831000937 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 649831000938 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 649831000939 molybdopterin cofactor binding site; other site 649831000940 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 649831000941 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 649831000942 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 649831000943 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 649831000944 4Fe-4S binding domain; Region: Fer4; pfam00037 649831000945 4Fe-4S binding domain; Region: Fer4; pfam00037 649831000946 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 649831000947 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 649831000948 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 649831000949 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 649831000950 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 649831000951 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 649831000952 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 649831000953 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 649831000954 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 649831000955 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 649831000956 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 649831000957 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 649831000958 substrate binding pocket [chemical binding]; other site 649831000959 chain length determination region; other site 649831000960 substrate-Mg2+ binding site; other site 649831000961 catalytic residues [active] 649831000962 aspartate-rich region 1; other site 649831000963 active site lid residues [active] 649831000964 aspartate-rich region 2; other site 649831000965 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831000966 Major Facilitator Superfamily; Region: MFS_1; pfam07690 649831000967 Transcriptional regulator [Transcription]; Region: IclR; COG1414 649831000968 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 649831000969 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 649831000970 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 649831000971 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 649831000972 DNA binding residues [nucleotide binding] 649831000973 Putative zinc-finger; Region: zf-HC2; pfam13490 649831000974 Predicted permeases [General function prediction only]; Region: RarD; COG2962 649831000975 Membrane protein of unknown function; Region: DUF360; pfam04020 649831000976 Protein of unknown function (DUF2984); Region: DUF2984; cl12752 649831000977 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 649831000978 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 649831000979 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 649831000980 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 649831000981 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 649831000982 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 649831000983 acetyl-CoA synthetase; Provisional; Region: PRK00174 649831000984 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 649831000985 active site 649831000986 CoA binding site [chemical binding]; other site 649831000987 acyl-activating enzyme (AAE) consensus motif; other site 649831000988 AMP binding site [chemical binding]; other site 649831000989 acetate binding site [chemical binding]; other site 649831000990 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 649831000991 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 649831000992 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 649831000993 anti sigma factor interaction site; other site 649831000994 regulatory phosphorylation site [posttranslational modification]; other site 649831000995 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 649831000996 Type II/IV secretion system protein; Region: T2SE; pfam00437 649831000997 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 649831000998 hexamer interface [polypeptide binding]; other site 649831000999 Walker B motif; other site 649831001000 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 649831001001 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 649831001002 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 649831001003 ATP binding site [chemical binding]; other site 649831001004 putative Mg++ binding site [ion binding]; other site 649831001005 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 649831001006 nucleotide binding region [chemical binding]; other site 649831001007 ATP-binding site [chemical binding]; other site 649831001008 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 649831001009 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 649831001010 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 649831001011 anti sigma factor interaction site; other site 649831001012 regulatory phosphorylation site [posttranslational modification]; other site 649831001013 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 649831001014 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 649831001015 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 649831001016 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 649831001017 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 649831001018 active site 649831001019 interdomain interaction site; other site 649831001020 putative metal-binding site [ion binding]; other site 649831001021 nucleotide binding site [chemical binding]; other site 649831001022 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 649831001023 domain I; other site 649831001024 phosphate binding site [ion binding]; other site 649831001025 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 649831001026 domain II; other site 649831001027 domain III; other site 649831001028 nucleotide binding site [chemical binding]; other site 649831001029 DNA binding groove [nucleotide binding] 649831001030 catalytic site [active] 649831001031 domain IV; other site 649831001032 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 649831001033 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 649831001034 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 649831001035 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 649831001036 FAD binding domain; Region: FAD_binding_4; pfam01565 649831001037 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 649831001038 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 649831001039 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831001040 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 649831001041 dimer interface [polypeptide binding]; other site 649831001042 active site 649831001043 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 649831001044 substrate binding site [chemical binding]; other site 649831001045 catalytic residue [active] 649831001046 H+ Antiporter protein; Region: 2A0121; TIGR00900 649831001047 thymidylate kinase; Validated; Region: tmk; PRK00698 649831001048 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 649831001049 TMP-binding site; other site 649831001050 ATP-binding site [chemical binding]; other site 649831001051 DNA polymerase III subunit delta'; Validated; Region: PRK07940 649831001052 DNA polymerase III subunit delta'; Validated; Region: PRK08485 649831001053 PSP1 C-terminal conserved region; Region: PSP1; cl00770 649831001054 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 649831001055 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 649831001056 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 649831001057 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831001058 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 649831001059 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 649831001060 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 649831001061 DNA binding residues [nucleotide binding] 649831001062 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 649831001063 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 649831001064 Walker A/P-loop; other site 649831001065 ATP binding site [chemical binding]; other site 649831001066 Q-loop/lid; other site 649831001067 ABC transporter signature motif; other site 649831001068 Walker B; other site 649831001069 D-loop; other site 649831001070 H-loop/switch region; other site 649831001071 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219 649831001072 Domain of unknown function (DUF397); Region: DUF397; pfam04149 649831001073 Domain of unknown function (DUF397); Region: DUF397; pfam04149 649831001074 Domain of unknown function (DUF397); Region: DUF397; pfam04149 649831001075 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 649831001076 non-specific DNA binding site [nucleotide binding]; other site 649831001077 salt bridge; other site 649831001078 sequence-specific DNA binding site [nucleotide binding]; other site 649831001079 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 649831001080 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 649831001081 intracellular protease, PfpI family; Region: PfpI; TIGR01382 649831001082 proposed catalytic triad [active] 649831001083 conserved cys residue [active] 649831001084 enterobactin exporter EntS; Provisional; Region: PRK10489 649831001085 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831001086 putative substrate translocation pore; other site 649831001087 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 649831001088 nudix motif; other site 649831001089 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 649831001090 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 649831001091 putative DNA binding site [nucleotide binding]; other site 649831001092 putative homodimer interface [polypeptide binding]; other site 649831001093 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 649831001094 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 649831001095 active site 649831001096 DNA binding site [nucleotide binding] 649831001097 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 649831001098 DNA binding site [nucleotide binding] 649831001099 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 649831001100 nucleotide binding site [chemical binding]; other site 649831001101 Predicted transcriptional regulators [Transcription]; Region: COG1695 649831001102 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 649831001103 Predicted membrane protein [Function unknown]; Region: COG4709 649831001104 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 649831001105 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 649831001106 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 649831001107 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 649831001108 ATP binding site [chemical binding]; other site 649831001109 putative Mg++ binding site [ion binding]; other site 649831001110 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 649831001111 nucleotide binding region [chemical binding]; other site 649831001112 ATP-binding site [chemical binding]; other site 649831001113 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 649831001114 WYL domain; Region: WYL; pfam13280 649831001115 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 649831001116 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 649831001117 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 649831001118 DNA-binding site [nucleotide binding]; DNA binding site 649831001119 RNA-binding motif; other site 649831001120 Menaquinone biosynthesis; Region: VitK2_biosynth; cl17475 649831001121 hypothetical protein; Provisional; Region: PRK08236 649831001122 H+ Antiporter protein; Region: 2A0121; TIGR00900 649831001123 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831001124 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 649831001125 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 649831001126 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 649831001127 MarR family; Region: MarR; pfam01047 649831001128 H+ Antiporter protein; Region: 2A0121; TIGR00900 649831001129 Transcriptional regulators [Transcription]; Region: FadR; COG2186 649831001130 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 649831001131 DNA-binding site [nucleotide binding]; DNA binding site 649831001132 cyanate transporter; Region: CynX; TIGR00896 649831001133 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831001134 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 649831001135 phosphoserine aminotransferase; Provisional; Region: PRK03080 649831001136 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 649831001137 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 649831001138 catalytic residue [active] 649831001139 citrate synthase 2; Provisional; Region: PRK12350 649831001140 Citrate synthase; Region: Citrate_synt; pfam00285 649831001141 oxalacetate binding site [chemical binding]; other site 649831001142 citrylCoA binding site [chemical binding]; other site 649831001143 coenzyme A binding site [chemical binding]; other site 649831001144 catalytic triad [active] 649831001145 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 649831001146 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 649831001147 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 649831001148 enterobactin exporter EntS; Provisional; Region: PRK10489 649831001149 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 649831001150 active site 649831001151 catalytic residues [active] 649831001152 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 649831001153 putative FMN binding site [chemical binding]; other site 649831001154 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 649831001155 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 649831001156 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 649831001157 active site 649831001158 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 649831001159 Domain of unknown function (DUF385); Region: DUF385; cl04387 649831001160 WYL domain; Region: WYL; cl14852 649831001161 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649831001162 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 649831001163 Walker A/P-loop; other site 649831001164 ATP binding site [chemical binding]; other site 649831001165 Q-loop/lid; other site 649831001166 ABC transporter signature motif; other site 649831001167 Walker B; other site 649831001168 D-loop; other site 649831001169 H-loop/switch region; other site 649831001170 response regulator; Provisional; Region: PRK09483 649831001171 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831001172 active site 649831001173 phosphorylation site [posttranslational modification] 649831001174 intermolecular recognition site; other site 649831001175 dimerization interface [polypeptide binding]; other site 649831001176 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649831001177 DNA binding residues [nucleotide binding] 649831001178 dimerization interface [polypeptide binding]; other site 649831001179 Histidine kinase; Region: HisKA_3; pfam07730 649831001180 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831001181 ATP binding site [chemical binding]; other site 649831001182 Mg2+ binding site [ion binding]; other site 649831001183 G-X-G motif; other site 649831001184 PspC domain; Region: PspC; pfam04024 649831001185 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 649831001186 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 649831001187 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 649831001188 active site 649831001189 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 649831001190 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 649831001191 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 649831001192 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 649831001193 Walker A/P-loop; other site 649831001194 ATP binding site [chemical binding]; other site 649831001195 Q-loop/lid; other site 649831001196 ABC transporter signature motif; other site 649831001197 Walker B; other site 649831001198 D-loop; other site 649831001199 H-loop/switch region; other site 649831001200 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 649831001201 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 649831001202 ATP binding site [chemical binding]; other site 649831001203 Mg2+ binding site [ion binding]; other site 649831001204 G-X-G motif; other site 649831001205 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 649831001206 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 649831001207 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 649831001208 motif II; other site 649831001209 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 649831001210 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 649831001211 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 649831001212 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 649831001213 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 649831001214 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 649831001215 active site 649831001216 catalytic tetrad [active] 649831001217 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 649831001218 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 649831001219 Coenzyme A binding pocket [chemical binding]; other site 649831001220 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 649831001221 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 649831001222 Walker A/P-loop; other site 649831001223 ATP binding site [chemical binding]; other site 649831001224 Q-loop/lid; other site 649831001225 ABC transporter signature motif; other site 649831001226 Walker B; other site 649831001227 D-loop; other site 649831001228 H-loop/switch region; other site 649831001229 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 649831001230 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 649831001231 PAS domain S-box; Region: sensory_box; TIGR00229 649831001232 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 649831001233 putative active site [active] 649831001234 heme pocket [chemical binding]; other site 649831001235 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 649831001236 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 649831001237 metal binding site [ion binding]; metal-binding site 649831001238 active site 649831001239 I-site; other site 649831001240 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 649831001241 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; pfam03663 649831001242 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 649831001243 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 649831001244 metal binding site [ion binding]; metal-binding site 649831001245 active site 649831001246 I-site; other site 649831001247 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 649831001248 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 649831001249 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 649831001250 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 649831001251 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 649831001252 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 649831001253 DNA binding residues [nucleotide binding] 649831001254 Putative zinc-finger; Region: zf-HC2; pfam13490 649831001255 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 649831001256 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831001257 putative substrate translocation pore; other site 649831001258 tetracycline repressor protein TetR; Provisional; Region: PRK13756 649831001259 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831001260 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 649831001261 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 649831001262 active site residue [active] 649831001263 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 649831001264 Domain of unknown function (DUF239); Region: DUF239; pfam03080 649831001265 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 649831001266 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 649831001267 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 649831001268 DNA binding residues [nucleotide binding] 649831001269 Protein of unknown function, DUF393; Region: DUF393; pfam04134 649831001270 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 649831001271 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 649831001272 TM-ABC transporter signature motif; other site 649831001273 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 649831001274 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 649831001275 TM-ABC transporter signature motif; other site 649831001276 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 649831001277 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 649831001278 Walker A/P-loop; other site 649831001279 ATP binding site [chemical binding]; other site 649831001280 Q-loop/lid; other site 649831001281 ABC transporter signature motif; other site 649831001282 Walker B; other site 649831001283 D-loop; other site 649831001284 H-loop/switch region; other site 649831001285 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 649831001286 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 649831001287 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 649831001288 putative ligand binding site [chemical binding]; other site 649831001289 Glycosyltransferase (GlcNAc); Region: GlcNAc; pfam11397 649831001290 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 649831001291 active site 649831001292 Domain of unknown function (DUF3432); Region: DUF3432; pfam11914 649831001293 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 649831001294 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 649831001295 large tegument protein UL36; Provisional; Region: PHA03247 649831001296 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 649831001297 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 649831001298 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 649831001299 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 649831001300 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 649831001301 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 649831001302 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 649831001303 Protein of unknown function (DUF690); Region: DUF690; cl04939 649831001304 Protein of unknown function (DUF690); Region: DUF690; cl04939 649831001305 Right handed beta helix region; Region: Beta_helix; pfam13229 649831001306 stage V sporulation protein K; Region: spore_V_K; TIGR02881 649831001307 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 649831001308 Walker A motif; other site 649831001309 ATP binding site [chemical binding]; other site 649831001310 Walker B motif; other site 649831001311 arginine finger; other site 649831001312 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 649831001313 hypothetical protein; Validated; Region: PRK00153 649831001314 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 649831001315 AAA ATPase domain; Region: AAA_16; pfam13191 649831001316 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 649831001317 binding surface 649831001318 TPR motif; other site 649831001319 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 649831001320 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 649831001321 DNA binding site [nucleotide binding] 649831001322 AAA ATPase domain; Region: AAA_16; pfam13191 649831001323 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649831001324 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649831001325 DNA binding residues [nucleotide binding] 649831001326 dimerization interface [polypeptide binding]; other site 649831001327 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 649831001328 Zn binding site [ion binding]; other site 649831001329 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 649831001330 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831001331 WHG domain; Region: WHG; pfam13305 649831001332 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 649831001333 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831001334 putative substrate translocation pore; other site 649831001335 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 649831001336 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831001337 active site 649831001338 phosphorylation site [posttranslational modification] 649831001339 intermolecular recognition site; other site 649831001340 dimerization interface [polypeptide binding]; other site 649831001341 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 649831001342 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 649831001343 metal binding site [ion binding]; metal-binding site 649831001344 active site 649831001345 I-site; other site 649831001346 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 649831001347 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 649831001348 RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950 649831001349 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 649831001350 anti-sigma factor, putative, ChrR family; Region: anti_sig_ChrR; TIGR02451 649831001351 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649831001352 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 649831001353 Walker A/P-loop; other site 649831001354 ATP binding site [chemical binding]; other site 649831001355 Q-loop/lid; other site 649831001356 ABC transporter signature motif; other site 649831001357 Walker B; other site 649831001358 D-loop; other site 649831001359 H-loop/switch region; other site 649831001360 pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590 649831001361 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 649831001362 ligand binding site; other site 649831001363 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 649831001364 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 649831001365 inhibitor-cofactor binding pocket; inhibition site 649831001366 pyridoxal 5'-phosphate binding site [chemical binding]; other site 649831001367 catalytic residue [active] 649831001368 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 649831001369 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 649831001370 NAD(P) binding site [chemical binding]; other site 649831001371 homodimer interface [polypeptide binding]; other site 649831001372 substrate binding site [chemical binding]; other site 649831001373 active site 649831001374 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 649831001375 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 649831001376 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831001377 NAD(P) binding site [chemical binding]; other site 649831001378 active site 649831001379 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 649831001380 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 649831001381 active site 649831001382 CoA binding site [chemical binding]; other site 649831001383 AMP binding site [chemical binding]; other site 649831001384 Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443 649831001385 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 649831001386 NAD(P) binding site [chemical binding]; other site 649831001387 catalytic residues [active] 649831001388 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 649831001389 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 649831001390 Ligand binding site; other site 649831001391 Putative Catalytic site; other site 649831001392 DXD motif; other site 649831001393 CopC domain; Region: CopC; pfam04234 649831001394 Beta-lactamase; Region: Beta-lactamase; pfam00144 649831001395 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 649831001396 Putative sensor; Region: Sensor; pfam13796 649831001397 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 649831001398 Histidine kinase; Region: HisKA_3; pfam07730 649831001399 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831001400 ATP binding site [chemical binding]; other site 649831001401 Mg2+ binding site [ion binding]; other site 649831001402 G-X-G motif; other site 649831001403 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649831001404 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831001405 active site 649831001406 phosphorylation site [posttranslational modification] 649831001407 intermolecular recognition site; other site 649831001408 dimerization interface [polypeptide binding]; other site 649831001409 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649831001410 DNA binding residues [nucleotide binding] 649831001411 MMPL family; Region: MMPL; pfam03176 649831001412 CsbD-like; Region: CsbD; cl17424 649831001413 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 649831001414 metal binding site [ion binding]; metal-binding site 649831001415 active site 649831001416 I-site; other site 649831001417 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 649831001418 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 649831001419 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 649831001420 active site 649831001421 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 649831001422 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 649831001423 pseudaminic acid synthase; Region: PseI; TIGR03586 649831001424 NeuB family; Region: NeuB; pfam03102 649831001425 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 649831001426 NeuB binding interface [polypeptide binding]; other site 649831001427 putative substrate binding site [chemical binding]; other site 649831001428 CrcB-like protein; Region: CRCB; pfam02537 649831001429 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 649831001430 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 649831001431 Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028 649831001432 mannose binding site [chemical binding]; other site 649831001433 dimerization interface [polypeptide binding]; other site 649831001434 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 649831001435 GAF domain; Region: GAF; pfam01590 649831001436 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 649831001437 metal binding site [ion binding]; metal-binding site 649831001438 active site 649831001439 I-site; other site 649831001440 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 649831001441 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 649831001442 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 649831001443 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 649831001444 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 649831001445 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 649831001446 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 649831001447 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649831001448 dimer interface [polypeptide binding]; other site 649831001449 conserved gate region; other site 649831001450 putative PBP binding loops; other site 649831001451 ABC-ATPase subunit interface; other site 649831001452 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 649831001453 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649831001454 dimer interface [polypeptide binding]; other site 649831001455 conserved gate region; other site 649831001456 putative PBP binding loops; other site 649831001457 ABC-ATPase subunit interface; other site 649831001458 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 649831001459 L-threonine dehydrogenase; Region: threonine_DH_like; cd08234 649831001460 putative NAD(P) binding site [chemical binding]; other site 649831001461 catalytic Zn binding site [ion binding]; other site 649831001462 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 649831001463 MarR family; Region: MarR; pfam01047 649831001464 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831001465 putative substrate translocation pore; other site 649831001466 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 649831001467 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 649831001468 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831001469 putative transporter; Provisional; Region: PRK11043 649831001470 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 649831001471 TAP-like protein; Region: Abhydrolase_4; pfam08386 649831001472 Predicted membrane protein [Function unknown]; Region: COG2119 649831001473 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 649831001474 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 649831001475 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 649831001476 Major Facilitator Superfamily; Region: MFS_1; pfam07690 649831001477 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831001478 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831001479 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 649831001480 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831001481 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 649831001482 binding surface 649831001483 TPR motif; other site 649831001484 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 649831001485 binding surface 649831001486 TPR motif; other site 649831001487 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 649831001488 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 649831001489 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 649831001490 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 649831001491 active site 649831001492 P-loop; other site 649831001493 phosphorylation site [posttranslational modification] 649831001494 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 649831001495 active site 649831001496 phosphorylation site [posttranslational modification] 649831001497 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206 649831001498 dimerization domain swap beta strand [polypeptide binding]; other site 649831001499 regulatory protein interface [polypeptide binding]; other site 649831001500 active site 649831001501 regulatory phosphorylation site [posttranslational modification]; other site 649831001502 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 649831001503 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 649831001504 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 649831001505 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 649831001506 Tautomerase enzyme; Region: Tautomerase; pfam01361 649831001507 active site 1 [active] 649831001508 dimer interface [polypeptide binding]; other site 649831001509 hexamer interface [polypeptide binding]; other site 649831001510 active site 2 [active] 649831001511 short chain dehydrogenase; Provisional; Region: PRK12937 649831001512 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 649831001513 NADP binding site [chemical binding]; other site 649831001514 homodimer interface [polypeptide binding]; other site 649831001515 active site 649831001516 substrate binding site [chemical binding]; other site 649831001517 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 649831001518 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 649831001519 Domain of unknown function DUF21; Region: DUF21; pfam01595 649831001520 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 649831001521 Transporter associated domain; Region: CorC_HlyC; smart01091 649831001522 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 649831001523 SpoOM protein; Region: Spo0M; pfam07070 649831001524 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 649831001525 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 649831001526 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 649831001527 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831001528 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831001529 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 649831001530 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 649831001531 metal binding site [ion binding]; metal-binding site 649831001532 active site 649831001533 I-site; other site 649831001534 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 649831001535 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831001536 NAD(P) binding site [chemical binding]; other site 649831001537 active site 649831001538 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649831001539 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 649831001540 Walker A/P-loop; other site 649831001541 ATP binding site [chemical binding]; other site 649831001542 Q-loop/lid; other site 649831001543 ABC transporter signature motif; other site 649831001544 Walker B; other site 649831001545 D-loop; other site 649831001546 H-loop/switch region; other site 649831001547 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 649831001548 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 649831001549 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 649831001550 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 649831001551 Predicted ATPase [General function prediction only]; Region: COG3903 649831001552 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 649831001553 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831001554 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 649831001555 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359 649831001556 putative dimer interface [polypeptide binding]; other site 649831001557 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 649831001558 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 649831001559 Glyco_18 domain; Region: Glyco_18; smart00636 649831001560 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 649831001561 active site 649831001562 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cd00110 649831001563 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 649831001564 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 649831001565 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 649831001566 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 649831001567 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 649831001568 DNA polymerase Ligase (LigD); Region: LigD_N; pfam13298 649831001569 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1672 649831001570 Sulfatase; Region: Sulfatase; cl17466 649831001571 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 649831001572 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 649831001573 putative NAD(P) binding site [chemical binding]; other site 649831001574 putative substrate binding site [chemical binding]; other site 649831001575 catalytic Zn binding site [ion binding]; other site 649831001576 structural Zn binding site [ion binding]; other site 649831001577 dimer interface [polypeptide binding]; other site 649831001578 Uncharacterized protein conserved in bacteria (DUF2186); Region: DUF2186; pfam09952 649831001579 Predicted nucleotidyltransferase [General function prediction only]; Region: COG4849 649831001580 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like; cd11354 649831001581 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 649831001582 active site 649831001583 catalytic site [active] 649831001584 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 649831001585 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 649831001586 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 649831001587 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 649831001588 DNA binding residues [nucleotide binding] 649831001589 Tubby C 2; Region: Tub_2; cl02043 649831001590 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 649831001591 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 649831001592 NAD binding site [chemical binding]; other site 649831001593 catalytic Zn binding site [ion binding]; other site 649831001594 structural Zn binding site [ion binding]; other site 649831001595 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 649831001596 classical (c) SDRs; Region: SDR_c; cd05233 649831001597 NAD(P) binding site [chemical binding]; other site 649831001598 active site 649831001599 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 649831001600 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 649831001601 active site 649831001602 catalytic tetrad [active] 649831001603 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 649831001604 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 649831001605 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 649831001606 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 649831001607 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 649831001608 dimer interface [polypeptide binding]; other site 649831001609 putative CheW interface [polypeptide binding]; other site 649831001610 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 649831001611 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 649831001612 metal binding site [ion binding]; metal-binding site 649831001613 active site 649831001614 I-site; other site 649831001615 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 649831001616 serine hydroxymethyltransferase; Provisional; Region: PRK13580 649831001617 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 649831001618 dimer interface [polypeptide binding]; other site 649831001619 active site 649831001620 glycine-pyridoxal phosphate binding site [chemical binding]; other site 649831001621 folate binding site [chemical binding]; other site 649831001622 Major royal jelly protein; Region: MRJP; pfam03022 649831001623 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649831001624 Walker A/P-loop; other site 649831001625 ATP binding site [chemical binding]; other site 649831001626 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831001627 putative substrate translocation pore; other site 649831001628 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 649831001629 active site 649831001630 metal binding site [ion binding]; metal-binding site 649831001631 homotetramer interface [polypeptide binding]; other site 649831001632 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 649831001633 sugar binding site [chemical binding]; other site 649831001634 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 649831001635 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 649831001636 ligand binding site [chemical binding]; other site 649831001637 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 649831001638 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 649831001639 TM-ABC transporter signature motif; other site 649831001640 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 649831001641 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649831001642 Walker A/P-loop; other site 649831001643 ATP binding site [chemical binding]; other site 649831001644 Q-loop/lid; other site 649831001645 ABC transporter signature motif; other site 649831001646 Walker B; other site 649831001647 D-loop; other site 649831001648 H-loop/switch region; other site 649831001649 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 649831001650 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 649831001651 active site 649831001652 catalytic tetrad [active] 649831001653 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 649831001654 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 649831001655 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 649831001656 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 649831001657 Cysteine-rich domain; Region: CCG; pfam02754 649831001658 Cysteine-rich domain; Region: CCG; pfam02754 649831001659 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 649831001660 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 649831001661 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 649831001662 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 649831001663 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 649831001664 anti sigma factor interaction site; other site 649831001665 regulatory phosphorylation site [posttranslational modification]; other site 649831001666 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 649831001667 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 649831001668 active site 649831001669 catalytic tetrad [active] 649831001670 Methyltransferase domain; Region: Methyltransf_31; pfam13847 649831001671 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649831001672 S-adenosylmethionine binding site [chemical binding]; other site 649831001673 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 649831001674 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 649831001675 Ligand Binding Site [chemical binding]; other site 649831001676 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 649831001677 dimer interface [polypeptide binding]; other site 649831001678 phosphorylation site [posttranslational modification] 649831001679 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831001680 ATP binding site [chemical binding]; other site 649831001681 Mg2+ binding site [ion binding]; other site 649831001682 G-X-G motif; other site 649831001683 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 649831001684 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 649831001685 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 649831001686 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 649831001687 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 649831001688 Adenosylhomocysteinase; Provisional; Region: PTZ00075 649831001689 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 649831001690 homotetramer interface [polypeptide binding]; other site 649831001691 ligand binding site [chemical binding]; other site 649831001692 catalytic site [active] 649831001693 NAD binding site [chemical binding]; other site 649831001694 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 649831001695 DNA binding site [nucleotide binding] 649831001696 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 649831001697 domain linker motif; other site 649831001698 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 649831001699 putative ligand binding site [chemical binding]; other site 649831001700 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 649831001701 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 649831001702 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 649831001703 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 649831001704 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 649831001705 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 649831001706 Metal-binding active site; metal-binding site 649831001707 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 649831001708 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 649831001709 active site 649831001710 catalytic residues [active] 649831001711 metal binding site [ion binding]; metal-binding site 649831001712 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 649831001713 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649831001714 Walker A/P-loop; other site 649831001715 ATP binding site [chemical binding]; other site 649831001716 Q-loop/lid; other site 649831001717 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 649831001718 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649831001719 Walker A/P-loop; other site 649831001720 ATP binding site [chemical binding]; other site 649831001721 Q-loop/lid; other site 649831001722 ABC transporter signature motif; other site 649831001723 Walker B; other site 649831001724 D-loop; other site 649831001725 H-loop/switch region; other site 649831001726 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 649831001727 Cytochrome P450; Region: p450; cl12078 649831001728 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 649831001729 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 649831001730 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 649831001731 Predicted flavoprotein [General function prediction only]; Region: COG0431 649831001732 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 649831001733 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 649831001734 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 649831001735 FAD binding domain; Region: FAD_binding_4; pfam01565 649831001736 Berberine and berberine like; Region: BBE; pfam08031 649831001737 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 649831001738 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 649831001739 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 649831001740 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 649831001741 N-terminal domain interface [polypeptide binding]; other site 649831001742 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 649831001743 putative metal binding site [ion binding]; other site 649831001744 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 649831001745 DNA methylase; Region: N6_N4_Mtase; cl17433 649831001746 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 649831001747 DNA binding site [nucleotide binding] 649831001748 active site 649831001749 Int/Topo IB signature motif; other site 649831001750 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 649831001751 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 649831001752 active site 649831001753 catalytic triad [active] 649831001754 oxyanion hole [active] 649831001755 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 649831001756 Trp docking motif [polypeptide binding]; other site 649831001757 active site 649831001758 PQQ-like domain; Region: PQQ_2; pfam13360 649831001759 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 649831001760 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 649831001761 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 649831001762 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 649831001763 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 649831001764 Dienelactone hydrolase family; Region: DLH; pfam01738 649831001765 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 649831001766 Carbohydrate Binding Module 6 (CBM6); appended to glycoside hydrolase (GH) domains, including GH5 (cellulase); Region: CBM6_cellulase-like; cd04080 649831001767 Ca binding site [ion binding]; other site 649831001768 ligand binding site I [chemical binding]; other site 649831001769 homodimer interface [polypeptide binding]; other site 649831001770 ligand binding site II [chemical binding]; other site 649831001771 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649831001772 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649831001773 DNA binding residues [nucleotide binding] 649831001774 dimerization interface [polypeptide binding]; other site 649831001775 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649831001776 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649831001777 DNA binding residues [nucleotide binding] 649831001778 dimerization interface [polypeptide binding]; other site 649831001779 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649831001780 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649831001781 DNA binding residues [nucleotide binding] 649831001782 dimerization interface [polypeptide binding]; other site 649831001783 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 649831001784 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 649831001785 Uncharacterized conserved protein [Function unknown]; Region: COG5276 649831001786 Domain of unknown function (DUF305); Region: DUF305; pfam03713 649831001787 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 649831001788 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831001789 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 649831001790 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 649831001791 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 649831001792 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 649831001793 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831001794 WHG domain; Region: WHG; pfam13305 649831001795 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 649831001796 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 649831001797 catalytic site [active] 649831001798 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 649831001799 Interdomain contacts; other site 649831001800 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 649831001801 dimer interface [polypeptide binding]; other site 649831001802 phosphorylation site [posttranslational modification] 649831001803 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831001804 ATP binding site [chemical binding]; other site 649831001805 Mg2+ binding site [ion binding]; other site 649831001806 G-X-G motif; other site 649831001807 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 649831001808 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 649831001809 dimer interface [polypeptide binding]; other site 649831001810 phosphorylation site [posttranslational modification] 649831001811 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831001812 ATP binding site [chemical binding]; other site 649831001813 Mg2+ binding site [ion binding]; other site 649831001814 G-X-G motif; other site 649831001815 Response regulator receiver domain; Region: Response_reg; pfam00072 649831001816 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831001817 active site 649831001818 phosphorylation site [posttranslational modification] 649831001819 intermolecular recognition site; other site 649831001820 dimerization interface [polypeptide binding]; other site 649831001821 Hpt domain; Region: Hpt; pfam01627 649831001822 putative binding surface; other site 649831001823 active site 649831001824 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 649831001825 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 649831001826 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 649831001827 active site 649831001828 metal binding site [ion binding]; metal-binding site 649831001829 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 649831001830 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 649831001831 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 649831001832 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 649831001833 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 649831001834 active site 649831001835 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 649831001836 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 649831001837 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cd02019 649831001838 active site 649831001839 Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141 649831001840 putative RNAase interaction site [polypeptide binding]; other site 649831001841 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 649831001842 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831001843 active site 649831001844 phosphorylation site [posttranslational modification] 649831001845 intermolecular recognition site; other site 649831001846 dimerization interface [polypeptide binding]; other site 649831001847 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 649831001848 DNA binding site [nucleotide binding] 649831001849 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 649831001850 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 649831001851 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 649831001852 active site 649831001853 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 649831001854 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831001855 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 649831001856 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 649831001857 active site 649831001858 catalytic site [active] 649831001859 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; pfam09261 649831001860 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 649831001861 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 649831001862 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649831001863 dimer interface [polypeptide binding]; other site 649831001864 conserved gate region; other site 649831001865 putative PBP binding loops; other site 649831001866 ABC-ATPase subunit interface; other site 649831001867 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 649831001868 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649831001869 dimer interface [polypeptide binding]; other site 649831001870 ABC-ATPase subunit interface; other site 649831001871 putative PBP binding loops; other site 649831001872 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 649831001873 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 649831001874 Transcriptional regulators [Transcription]; Region: PurR; COG1609 649831001875 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 649831001876 DNA binding site [nucleotide binding] 649831001877 domain linker motif; other site 649831001878 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 649831001879 dimerization interface [polypeptide binding]; other site 649831001880 ligand binding site [chemical binding]; other site 649831001881 Methyltransferase domain; Region: Methyltransf_23; pfam13489 649831001882 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649831001883 S-adenosylmethionine binding site [chemical binding]; other site 649831001884 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 649831001885 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 649831001886 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436 649831001887 putative dimerization interface [polypeptide binding]; other site 649831001888 Subunit A of Class III extradiol dioxygenases; Region: Extradiol_Dioxygenase_3A_like; cl06673 649831001889 dimer interface [polypeptide binding]; other site 649831001890 tetramer interface [polypeptide binding]; other site 649831001891 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 649831001892 active site 649831001893 metal binding site [ion binding]; metal-binding site 649831001894 Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100 649831001895 active site 649831001896 citrylCoA binding site [chemical binding]; other site 649831001897 oxalacetate binding site [chemical binding]; other site 649831001898 coenzyme A binding site [chemical binding]; other site 649831001899 catalytic triad [active] 649831001900 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 649831001901 CoA-transferase family III; Region: CoA_transf_3; pfam02515 649831001902 hypothetical protein; Provisional; Region: PRK08204 649831001903 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 649831001904 active site 649831001905 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 649831001906 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 649831001907 Bacterial transcriptional regulator; Region: IclR; pfam01614 649831001908 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 649831001909 DPG_synthase is involved in protein N-linked glycosylation; Region: DPG_synthase; cd04188 649831001910 Ligand binding site; other site 649831001911 Ligand binding site; other site 649831001912 Ligand binding site; other site 649831001913 Putative Catalytic site; other site 649831001914 DXD motif; other site 649831001915 Predicted membrane protein [Function unknown]; Region: COG2246 649831001916 GtrA-like protein; Region: GtrA; pfam04138 649831001917 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 649831001918 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 649831001919 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 649831001920 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 649831001921 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 649831001922 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 649831001923 dimer interface [polypeptide binding]; other site 649831001924 phosphorylation site [posttranslational modification] 649831001925 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831001926 ATP binding site [chemical binding]; other site 649831001927 Mg2+ binding site [ion binding]; other site 649831001928 G-X-G motif; other site 649831001929 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 649831001930 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831001931 active site 649831001932 phosphorylation site [posttranslational modification] 649831001933 intermolecular recognition site; other site 649831001934 dimerization interface [polypeptide binding]; other site 649831001935 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 649831001936 DNA binding site [nucleotide binding] 649831001937 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 649831001938 Cytochrome P450; Region: p450; cl12078 649831001939 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831001940 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 649831001941 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 649831001942 binding surface 649831001943 TPR motif; other site 649831001944 TPR repeat; Region: TPR_11; pfam13414 649831001945 Smr domain; Region: Smr; pfam01713 649831001946 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 649831001947 Peptidase family M28; Region: Peptidase_M28; pfam04389 649831001948 metal binding site [ion binding]; metal-binding site 649831001949 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 649831001950 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831001951 active site 649831001952 phosphorylation site [posttranslational modification] 649831001953 intermolecular recognition site; other site 649831001954 dimerization interface [polypeptide binding]; other site 649831001955 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 649831001956 CHASE3 domain; Region: CHASE3; pfam05227 649831001957 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 649831001958 dimerization interface [polypeptide binding]; other site 649831001959 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 649831001960 dimer interface [polypeptide binding]; other site 649831001961 phosphorylation site [posttranslational modification] 649831001962 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831001963 ATP binding site [chemical binding]; other site 649831001964 Mg2+ binding site [ion binding]; other site 649831001965 G-X-G motif; other site 649831001966 Response regulator receiver domain; Region: Response_reg; pfam00072 649831001967 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831001968 active site 649831001969 phosphorylation site [posttranslational modification] 649831001970 intermolecular recognition site; other site 649831001971 dimerization interface [polypeptide binding]; other site 649831001972 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 649831001973 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 649831001974 active site 649831001975 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831001976 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 649831001977 NAD(P) binding site [chemical binding]; other site 649831001978 active site 649831001979 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 649831001980 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 649831001981 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 649831001982 Catalytic domain of Protein Kinases; Region: PKc; cd00180 649831001983 active site 649831001984 ATP binding site [chemical binding]; other site 649831001985 substrate binding site [chemical binding]; other site 649831001986 activation loop (A-loop); other site 649831001987 Cellulose binding domain; Region: CBM_2; pfam00553 649831001988 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 649831001989 TrkA-N domain; Region: TrkA_N; pfam02254 649831001990 TrkA-C domain; Region: TrkA_C; pfam02080 649831001991 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 649831001992 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 649831001993 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 649831001994 classical (c) SDRs; Region: SDR_c; cd05233 649831001995 NAD(P) binding site [chemical binding]; other site 649831001996 active site 649831001997 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 649831001998 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 649831001999 ATP binding site [chemical binding]; other site 649831002000 putative Mg++ binding site [ion binding]; other site 649831002001 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 649831002002 nucleotide binding region [chemical binding]; other site 649831002003 ATP-binding site [chemical binding]; other site 649831002004 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 649831002005 NlpC/P60 family; Region: NLPC_P60; pfam00877 649831002006 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 649831002007 putative homodimer interface [polypeptide binding]; other site 649831002008 putative homotetramer interface [polypeptide binding]; other site 649831002009 putative allosteric switch controlling residues; other site 649831002010 putative metal binding site [ion binding]; other site 649831002011 putative homodimer-homodimer interface [polypeptide binding]; other site 649831002012 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 649831002013 metal-binding site [ion binding] 649831002014 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 649831002015 heme binding pocket [chemical binding]; other site 649831002016 heme ligand [chemical binding]; other site 649831002017 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 649831002018 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 649831002019 DEAD-like helicases superfamily; Region: DEXDc; smart00487 649831002020 ATP binding site [chemical binding]; other site 649831002021 Mg++ binding site [ion binding]; other site 649831002022 motif III; other site 649831002023 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 649831002024 nucleotide binding region [chemical binding]; other site 649831002025 ATP-binding site [chemical binding]; other site 649831002026 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 649831002027 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 649831002028 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831002029 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 649831002030 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 649831002031 catalytic site [active] 649831002032 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 649831002033 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 649831002034 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 649831002035 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 649831002036 ATP binding site [chemical binding]; other site 649831002037 substrate interface [chemical binding]; other site 649831002038 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 649831002039 active site residue [active] 649831002040 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 649831002041 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 649831002042 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 649831002043 Serine hydrolase; Region: Ser_hydrolase; cl17834 649831002044 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 649831002045 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 649831002046 putative catalytic cysteine [active] 649831002047 gamma-glutamyl kinase; Provisional; Region: PRK05429 649831002048 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 649831002049 nucleotide binding site [chemical binding]; other site 649831002050 homotetrameric interface [polypeptide binding]; other site 649831002051 putative phosphate binding site [ion binding]; other site 649831002052 putative allosteric binding site; other site 649831002053 PUA domain; Region: PUA; pfam01472 649831002054 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 649831002055 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 649831002056 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831002057 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 649831002058 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 649831002059 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 649831002060 NADH dehydrogenase subunit B; Validated; Region: PRK06411 649831002061 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 649831002062 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 649831002063 Coenzyme A binding pocket [chemical binding]; other site 649831002064 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 649831002065 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 649831002066 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 649831002067 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 649831002068 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 649831002069 DNA binding residues [nucleotide binding] 649831002070 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 649831002071 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 649831002072 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 649831002073 4Fe-4S binding domain; Region: Fer4; pfam00037 649831002074 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 649831002075 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 649831002076 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 649831002077 proton-translocating NADH-quinone oxidoreductase, chain M; Region: NDH_I_M; TIGR01972 649831002078 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 649831002079 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 649831002080 Peptidase family M48; Region: Peptidase_M48; cl12018 649831002081 Domain of unknown function (DUF4180); Region: DUF4180; pfam13788 649831002082 Helix-turn-helix domain; Region: HTH_17; pfam12728 649831002083 short chain dehydrogenase; Provisional; Region: PRK06500 649831002084 classical (c) SDRs; Region: SDR_c; cd05233 649831002085 NAD(P) binding site [chemical binding]; other site 649831002086 active site 649831002087 Methyltransferase domain; Region: Methyltransf_31; pfam13847 649831002088 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649831002089 S-adenosylmethionine binding site [chemical binding]; other site 649831002090 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 649831002091 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 649831002092 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 649831002093 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 649831002094 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 649831002095 MOSC domain; Region: MOSC; pfam03473 649831002096 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 649831002097 DNA binding site [nucleotide binding] 649831002098 active site 649831002099 Int/Topo IB signature motif; other site 649831002100 catalytic residues [active] 649831002101 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 649831002102 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 649831002103 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 649831002104 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 649831002105 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 649831002106 metal binding site [ion binding]; metal-binding site 649831002107 active site 649831002108 I-site; other site 649831002109 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 649831002110 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 649831002111 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 649831002112 active site 649831002113 catalytic site [active] 649831002114 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 649831002115 active site 2 [active] 649831002116 active site 1 [active] 649831002117 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 649831002118 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 649831002119 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 649831002120 putative homodimer interface [polypeptide binding]; other site 649831002121 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 649831002122 heterodimer interface [polypeptide binding]; other site 649831002123 homodimer interface [polypeptide binding]; other site 649831002124 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 649831002125 mRNA/rRNA interface [nucleotide binding]; other site 649831002126 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 649831002127 23S rRNA interface [nucleotide binding]; other site 649831002128 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 649831002129 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 649831002130 core dimer interface [polypeptide binding]; other site 649831002131 peripheral dimer interface [polypeptide binding]; other site 649831002132 L10 interface [polypeptide binding]; other site 649831002133 L11 interface [polypeptide binding]; other site 649831002134 putative EF-Tu interaction site [polypeptide binding]; other site 649831002135 putative EF-G interaction site [polypeptide binding]; other site 649831002136 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 649831002137 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 649831002138 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 649831002139 RPB1 interaction site [polypeptide binding]; other site 649831002140 RPB10 interaction site [polypeptide binding]; other site 649831002141 RPB11 interaction site [polypeptide binding]; other site 649831002142 RPB3 interaction site [polypeptide binding]; other site 649831002143 RPB12 interaction site [polypeptide binding]; other site 649831002144 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 649831002145 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 649831002146 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 649831002147 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 649831002148 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 649831002149 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 649831002150 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 649831002151 G-loop; other site 649831002152 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 649831002153 DNA binding site [nucleotide binding] 649831002154 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 649831002155 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 649831002156 S17 interaction site [polypeptide binding]; other site 649831002157 S8 interaction site; other site 649831002158 16S rRNA interaction site [nucleotide binding]; other site 649831002159 streptomycin interaction site [chemical binding]; other site 649831002160 23S rRNA interaction site [nucleotide binding]; other site 649831002161 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 649831002162 30S ribosomal protein S7; Validated; Region: PRK05302 649831002163 elongation factor G; Reviewed; Region: PRK00007 649831002164 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 649831002165 G1 box; other site 649831002166 putative GEF interaction site [polypeptide binding]; other site 649831002167 GTP/Mg2+ binding site [chemical binding]; other site 649831002168 Switch I region; other site 649831002169 G2 box; other site 649831002170 G3 box; other site 649831002171 Switch II region; other site 649831002172 G4 box; other site 649831002173 G5 box; other site 649831002174 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 649831002175 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 649831002176 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 649831002177 elongation factor Tu; Reviewed; Region: PRK00049 649831002178 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 649831002179 G1 box; other site 649831002180 GEF interaction site [polypeptide binding]; other site 649831002181 GTP/Mg2+ binding site [chemical binding]; other site 649831002182 Switch I region; other site 649831002183 G2 box; other site 649831002184 G3 box; other site 649831002185 Switch II region; other site 649831002186 G4 box; other site 649831002187 G5 box; other site 649831002188 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 649831002189 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 649831002190 Antibiotic Binding Site [chemical binding]; other site 649831002191 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 649831002192 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 649831002193 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 649831002194 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 649831002195 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 649831002196 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 649831002197 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 649831002198 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 649831002199 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 649831002200 protein-rRNA interface [nucleotide binding]; other site 649831002201 putative translocon binding site; other site 649831002202 ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009 649831002203 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 649831002204 G-X-X-G motif; other site 649831002205 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 649831002206 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 649831002207 23S rRNA interface [nucleotide binding]; other site 649831002208 5S rRNA interface [nucleotide binding]; other site 649831002209 putative antibiotic binding site [chemical binding]; other site 649831002210 L25 interface [polypeptide binding]; other site 649831002211 L27 interface [polypeptide binding]; other site 649831002212 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 649831002213 putative translocon interaction site; other site 649831002214 signal recognition particle (SRP54) interaction site; other site 649831002215 L23 interface [polypeptide binding]; other site 649831002216 trigger factor interaction site; other site 649831002217 23S rRNA interface [nucleotide binding]; other site 649831002218 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 649831002219 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 649831002220 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 649831002221 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 649831002222 RNA binding site [nucleotide binding]; other site 649831002223 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 649831002224 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 649831002225 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 649831002226 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 649831002227 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 649831002228 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 649831002229 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 649831002230 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 649831002231 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 649831002232 5S rRNA interface [nucleotide binding]; other site 649831002233 L27 interface [polypeptide binding]; other site 649831002234 23S rRNA interface [nucleotide binding]; other site 649831002235 L5 interface [polypeptide binding]; other site 649831002236 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 649831002237 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 649831002238 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 649831002239 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 649831002240 23S rRNA binding site [nucleotide binding]; other site 649831002241 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 649831002242 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 649831002243 SecY translocase; Region: SecY; pfam00344 649831002244 adenylate kinase; Reviewed; Region: adk; PRK00279 649831002245 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 649831002246 AMP-binding site [chemical binding]; other site 649831002247 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 649831002248 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 649831002249 active site 649831002250 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 649831002251 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 649831002252 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 649831002253 rRNA binding site [nucleotide binding]; other site 649831002254 predicted 30S ribosome binding site; other site 649831002255 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 649831002256 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 649831002257 30S ribosomal protein S13; Region: bact_S13; TIGR03631 649831002258 30S ribosomal protein S11; Validated; Region: PRK05309 649831002259 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 649831002260 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 649831002261 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 649831002262 RNA binding surface [nucleotide binding]; other site 649831002263 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 649831002264 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 649831002265 alphaNTD homodimer interface [polypeptide binding]; other site 649831002266 alphaNTD - beta interaction site [polypeptide binding]; other site 649831002267 alphaNTD - beta' interaction site [polypeptide binding]; other site 649831002268 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 649831002269 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 649831002270 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 649831002271 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 649831002272 dimerization interface 3.5A [polypeptide binding]; other site 649831002273 active site 649831002274 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 649831002275 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831002276 NAD(P) binding site [chemical binding]; other site 649831002277 active site 649831002278 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 649831002279 salt bridge; other site 649831002280 non-specific DNA binding site [nucleotide binding]; other site 649831002281 sequence-specific DNA binding site [nucleotide binding]; other site 649831002282 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649831002283 S-adenosylmethionine binding site [chemical binding]; other site 649831002284 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 649831002285 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649831002286 Walker A/P-loop; other site 649831002287 ATP binding site [chemical binding]; other site 649831002288 Q-loop/lid; other site 649831002289 ABC transporter signature motif; other site 649831002290 Walker B; other site 649831002291 D-loop; other site 649831002292 H-loop/switch region; other site 649831002293 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 649831002294 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 649831002295 thiamine phosphate binding site [chemical binding]; other site 649831002296 active site 649831002297 pyrophosphate binding site [ion binding]; other site 649831002298 hydroxyglutarate oxidase; Provisional; Region: PRK11728 649831002299 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 649831002300 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 649831002301 thiS-thiF/thiG interaction site; other site 649831002302 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 649831002303 ThiS interaction site; other site 649831002304 putative active site [active] 649831002305 tetramer interface [polypeptide binding]; other site 649831002306 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 649831002307 thiamine phosphate binding site [chemical binding]; other site 649831002308 active site 649831002309 pyrophosphate binding site [ion binding]; other site 649831002310 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 649831002311 dimer interface [polypeptide binding]; other site 649831002312 substrate binding site [chemical binding]; other site 649831002313 ATP binding site [chemical binding]; other site 649831002314 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 649831002315 ThiC-associated domain; Region: ThiC-associated; pfam13667 649831002316 ThiC family; Region: ThiC; pfam01964 649831002317 ribonuclease; Region: Ribonuclease; pfam00545 649831002318 active site 649831002319 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 649831002320 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 649831002321 NMT1/THI5 like; Region: NMT1; pfam09084 649831002322 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 649831002323 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649831002324 dimer interface [polypeptide binding]; other site 649831002325 conserved gate region; other site 649831002326 putative PBP binding loops; other site 649831002327 ABC-ATPase subunit interface; other site 649831002328 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 649831002329 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 649831002330 Nitrate and nitrite sensing; Region: NIT; pfam08376 649831002331 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 649831002332 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831002333 ATP binding site [chemical binding]; other site 649831002334 Mg2+ binding site [ion binding]; other site 649831002335 G-X-G motif; other site 649831002336 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 649831002337 Protein of unknown function (DUF742); Region: DUF742; pfam05331 649831002338 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 649831002339 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 649831002340 G1 box; other site 649831002341 GTP/Mg2+ binding site [chemical binding]; other site 649831002342 G2 box; other site 649831002343 Switch I region; other site 649831002344 G3 box; other site 649831002345 Switch II region; other site 649831002346 G4 box; other site 649831002347 G5 box; other site 649831002348 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 649831002349 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 649831002350 active site 649831002351 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 649831002352 DNA binding site [nucleotide binding] 649831002353 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 649831002354 23S rRNA interface [nucleotide binding]; other site 649831002355 L3 interface [polypeptide binding]; other site 649831002356 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 649831002357 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 649831002358 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 649831002359 active site 649831002360 substrate binding site [chemical binding]; other site 649831002361 metal binding site [ion binding]; metal-binding site 649831002362 aminotransferase; Validated; Region: PRK07777 649831002363 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 649831002364 pyridoxal 5'-phosphate binding site [chemical binding]; other site 649831002365 homodimer interface [polypeptide binding]; other site 649831002366 catalytic residue [active] 649831002367 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 649831002368 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 649831002369 glutaminase active site [active] 649831002370 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 649831002371 dimer interface [polypeptide binding]; other site 649831002372 active site 649831002373 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 649831002374 dimer interface [polypeptide binding]; other site 649831002375 active site 649831002376 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 649831002377 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 649831002378 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 649831002379 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 649831002380 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 649831002381 alanine racemase; Reviewed; Region: alr; PRK00053 649831002382 active site 649831002383 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 649831002384 dimer interface [polypeptide binding]; other site 649831002385 substrate binding site [chemical binding]; other site 649831002386 catalytic residues [active] 649831002387 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 649831002388 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 649831002389 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 649831002390 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 649831002391 ligand binding site [chemical binding]; other site 649831002392 active site 649831002393 UGI interface [polypeptide binding]; other site 649831002394 catalytic site [active] 649831002395 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 649831002396 Glycoprotease family; Region: Peptidase_M22; pfam00814 649831002397 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 649831002398 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 649831002399 Coenzyme A binding pocket [chemical binding]; other site 649831002400 UGMP family protein; Validated; Region: PRK09604 649831002401 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 649831002402 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 649831002403 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 649831002404 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649831002405 Q-loop/lid; other site 649831002406 ABC transporter signature motif; other site 649831002407 Walker B; other site 649831002408 D-loop; other site 649831002409 H-loop/switch region; other site 649831002410 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 649831002411 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 649831002412 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649831002413 Walker A/P-loop; other site 649831002414 ATP binding site [chemical binding]; other site 649831002415 Q-loop/lid; other site 649831002416 ABC transporter signature motif; other site 649831002417 Walker B; other site 649831002418 D-loop; other site 649831002419 H-loop/switch region; other site 649831002420 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 649831002421 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 649831002422 FeS/SAM binding site; other site 649831002423 Protein kinase domain; Region: Pkinase; pfam00069 649831002424 Catalytic domain of Protein Kinases; Region: PKc; cd00180 649831002425 active site 649831002426 ATP binding site [chemical binding]; other site 649831002427 substrate binding site [chemical binding]; other site 649831002428 activation loop (A-loop); other site 649831002429 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 649831002430 active site 649831002431 zinc binding site [ion binding]; other site 649831002432 MarR family; Region: MarR_2; pfam12802 649831002433 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 649831002434 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 649831002435 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 649831002436 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 649831002437 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 649831002438 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 649831002439 TM-ABC transporter signature motif; other site 649831002440 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 649831002441 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 649831002442 Walker A/P-loop; other site 649831002443 ATP binding site [chemical binding]; other site 649831002444 Q-loop/lid; other site 649831002445 ABC transporter signature motif; other site 649831002446 Walker B; other site 649831002447 D-loop; other site 649831002448 H-loop/switch region; other site 649831002449 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 649831002450 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 649831002451 putative ligand binding site [chemical binding]; other site 649831002452 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 649831002453 putative deacylase active site [active] 649831002454 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 649831002455 oligomerisation interface [polypeptide binding]; other site 649831002456 mobile loop; other site 649831002457 roof hairpin; other site 649831002458 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 649831002459 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 649831002460 ring oligomerisation interface [polypeptide binding]; other site 649831002461 ATP/Mg binding site [chemical binding]; other site 649831002462 stacking interactions; other site 649831002463 hinge regions; other site 649831002464 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 649831002465 Moco binding site; other site 649831002466 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 649831002467 metal coordination site [ion binding]; other site 649831002468 dimerization interface [polypeptide binding]; other site 649831002469 Transcription factor WhiB; Region: Whib; pfam02467 649831002470 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649831002471 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649831002472 DNA binding residues [nucleotide binding] 649831002473 dimerization interface [polypeptide binding]; other site 649831002474 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 649831002475 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 649831002476 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 649831002477 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 649831002478 active site 649831002479 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 649831002480 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 649831002481 phosphate binding site [ion binding]; other site 649831002482 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 649831002483 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 649831002484 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 649831002485 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 649831002486 Peptidase family M1; Region: Peptidase_M1; pfam01433 649831002487 Zn binding site [ion binding]; other site 649831002488 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 649831002489 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 649831002490 active site 649831002491 catalytic residues [active] 649831002492 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 649831002493 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 649831002494 active site 649831002495 catalytic residues [active] 649831002496 GMP synthase; Reviewed; Region: guaA; PRK00074 649831002497 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 649831002498 AMP/PPi binding site [chemical binding]; other site 649831002499 candidate oxyanion hole; other site 649831002500 catalytic triad [active] 649831002501 potential glutamine specificity residues [chemical binding]; other site 649831002502 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 649831002503 ATP Binding subdomain [chemical binding]; other site 649831002504 Ligand Binding sites [chemical binding]; other site 649831002505 Dimerization subdomain; other site 649831002506 PspC domain; Region: PspC; pfam04024 649831002507 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 649831002508 nudix motif; other site 649831002509 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 649831002510 nudix motif; other site 649831002511 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 649831002512 nudix motif; other site 649831002513 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 649831002514 nudix motif; other site 649831002515 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 649831002516 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 649831002517 PspC domain; Region: PspC; cl00864 649831002518 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 649831002519 PspC domain; Region: PspC; pfam04024 649831002520 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 649831002521 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831002522 ATP binding site [chemical binding]; other site 649831002523 Mg2+ binding site [ion binding]; other site 649831002524 G-X-G motif; other site 649831002525 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649831002526 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831002527 active site 649831002528 phosphorylation site [posttranslational modification] 649831002529 intermolecular recognition site; other site 649831002530 dimerization interface [polypeptide binding]; other site 649831002531 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649831002532 DNA binding residues [nucleotide binding] 649831002533 dimerization interface [polypeptide binding]; other site 649831002534 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 649831002535 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 649831002536 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 649831002537 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649831002538 conserved gate region; other site 649831002539 putative PBP binding loops; other site 649831002540 ABC-ATPase subunit interface; other site 649831002541 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 649831002542 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649831002543 dimer interface [polypeptide binding]; other site 649831002544 conserved gate region; other site 649831002545 putative PBP binding loops; other site 649831002546 ABC-ATPase subunit interface; other site 649831002547 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 649831002548 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 649831002549 Walker A/P-loop; other site 649831002550 ATP binding site [chemical binding]; other site 649831002551 Q-loop/lid; other site 649831002552 ABC transporter signature motif; other site 649831002553 Walker B; other site 649831002554 D-loop; other site 649831002555 H-loop/switch region; other site 649831002556 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 649831002557 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 649831002558 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 649831002559 Walker A/P-loop; other site 649831002560 ATP binding site [chemical binding]; other site 649831002561 Q-loop/lid; other site 649831002562 ABC transporter signature motif; other site 649831002563 Walker B; other site 649831002564 D-loop; other site 649831002565 H-loop/switch region; other site 649831002566 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 649831002567 Chorismate mutase type II; Region: CM_2; cl00693 649831002568 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 649831002569 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 649831002570 putative active site [active] 649831002571 putative metal binding site [ion binding]; other site 649831002572 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 649831002573 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 649831002574 Part of AAA domain; Region: AAA_19; pfam13245 649831002575 Family description; Region: UvrD_C_2; pfam13538 649831002576 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 649831002577 Peptidase family M23; Region: Peptidase_M23; pfam01551 649831002578 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 649831002579 Peptidase family M23; Region: Peptidase_M23; pfam01551 649831002580 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 649831002581 B12 binding site [chemical binding]; other site 649831002582 cobalt ligand [ion binding]; other site 649831002583 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 649831002584 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 649831002585 CoA-ligase; Region: Ligase_CoA; pfam00549 649831002586 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 649831002587 CoA binding domain; Region: CoA_binding; smart00881 649831002588 CoA-ligase; Region: Ligase_CoA; pfam00549 649831002589 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 649831002590 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 649831002591 active site 649831002592 substrate binding site [chemical binding]; other site 649831002593 cosubstrate binding site; other site 649831002594 catalytic site [active] 649831002595 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 649831002596 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 649831002597 purine monophosphate binding site [chemical binding]; other site 649831002598 dimer interface [polypeptide binding]; other site 649831002599 putative catalytic residues [active] 649831002600 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 649831002601 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 649831002602 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 649831002603 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 649831002604 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 649831002605 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 649831002606 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 649831002607 isocitrate dehydrogenase; Validated; Region: PRK08299 649831002608 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 649831002609 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 649831002610 dimer interface [polypeptide binding]; other site 649831002611 active site 649831002612 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 649831002613 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 649831002614 DNA-binding site [nucleotide binding]; DNA binding site 649831002615 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 649831002616 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 649831002617 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 649831002618 active site 649831002619 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 649831002620 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 649831002621 Methyltransferase domain; Region: Methyltransf_23; pfam13489 649831002622 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 649831002623 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 649831002624 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 649831002625 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 649831002626 Chain length determinant protein; Region: Wzz; pfam02706 649831002627 Chain length determinant protein; Region: Wzz; cl15801 649831002628 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 649831002629 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Validated; Region: PRK05537 649831002630 PUA-like domain; Region: PUA_2; pfam14306 649831002631 ATP-sulfurylase; Region: ATP-sulfurylase; pfam01747 649831002632 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 649831002633 ligand-binding site [chemical binding]; other site 649831002634 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 649831002635 Helix-turn-helix domain; Region: HTH_18; pfam12833 649831002636 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 649831002637 SnoaL-like domain; Region: SnoaL_2; pfam12680 649831002638 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 649831002639 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 649831002640 ADP-ribose binding site [chemical binding]; other site 649831002641 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 649831002642 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 649831002643 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649831002644 Walker A/P-loop; other site 649831002645 ATP binding site [chemical binding]; other site 649831002646 Q-loop/lid; other site 649831002647 ABC transporter signature motif; other site 649831002648 Walker B; other site 649831002649 D-loop; other site 649831002650 H-loop/switch region; other site 649831002651 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 649831002652 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 649831002653 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 649831002654 Walker A/P-loop; other site 649831002655 ATP binding site [chemical binding]; other site 649831002656 Q-loop/lid; other site 649831002657 ABC transporter signature motif; other site 649831002658 Walker B; other site 649831002659 D-loop; other site 649831002660 H-loop/switch region; other site 649831002661 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 649831002662 Phosphoenolpyruvate carboxylase; Region: PEPcase; pfam00311 649831002663 HypX protein, N-terminal hydrolase domain; Region: FMT_core_HypX_N; cd08650 649831002664 putative active site [active] 649831002665 putative substrate binding site [chemical binding]; other site 649831002666 putative cosubstrate binding site; other site 649831002667 catalytic site [active] 649831002668 C-terminal subdomain of the Formyltransferase-like domain found in HypX-like proteins; Region: FMT_C_HypX; cd08701 649831002669 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 649831002670 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 649831002671 substrate binding site [chemical binding]; other site 649831002672 oxyanion hole (OAH) forming residues; other site 649831002673 trimer interface [polypeptide binding]; other site 649831002674 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 649831002675 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 649831002676 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 649831002677 ATP binding site [chemical binding]; other site 649831002678 putative Mg++ binding site [ion binding]; other site 649831002679 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 649831002680 nucleotide binding region [chemical binding]; other site 649831002681 ATP-binding site [chemical binding]; other site 649831002682 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 649831002683 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 649831002684 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 649831002685 homodimer interface [polypeptide binding]; other site 649831002686 metal binding site [ion binding]; metal-binding site 649831002687 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 649831002688 enolase; Provisional; Region: eno; PRK00077 649831002689 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 649831002690 dimer interface [polypeptide binding]; other site 649831002691 metal binding site [ion binding]; metal-binding site 649831002692 substrate binding pocket [chemical binding]; other site 649831002693 Septum formation initiator; Region: DivIC; pfam04977 649831002694 Protein of unknown function (DUF501); Region: DUF501; pfam04417 649831002695 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 649831002696 Coenzyme A binding pocket [chemical binding]; other site 649831002697 exopolyphosphatase; Region: exo_poly_only; TIGR03706 649831002698 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 649831002699 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 649831002700 Predicted transcriptional regulators [Transcription]; Region: COG1695 649831002701 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 649831002702 Fe-S cluster binding site [ion binding]; other site 649831002703 DNA binding site [nucleotide binding] 649831002704 active site 649831002705 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 649831002706 MoxR-like ATPases [General function prediction only]; Region: COG0714 649831002707 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 649831002708 Walker A motif; other site 649831002709 ATP binding site [chemical binding]; other site 649831002710 Walker B motif; other site 649831002711 arginine finger; other site 649831002712 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 649831002713 Protein of unknown function DUF58; Region: DUF58; pfam01882 649831002714 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 649831002715 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 649831002716 Mitochondrial small ribosomal subunit Rsm22; Region: Rsm22; cl17847 649831002717 Bax inhibitor 1 like; Region: BaxI_1; cl17691 649831002718 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 649831002719 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 649831002720 dimer interface [polypeptide binding]; other site 649831002721 active site 649831002722 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 649831002723 active site 649831002724 catalytic triad [active] 649831002725 oxyanion hole [active] 649831002726 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 649831002727 active site 649831002728 catalytic triad [active] 649831002729 oxyanion hole [active] 649831002730 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 649831002731 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 649831002732 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 649831002733 dimer interface [polypeptide binding]; other site 649831002734 pyridoxal 5'-phosphate binding site [chemical binding]; other site 649831002735 catalytic residue [active] 649831002736 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 649831002737 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 649831002738 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 649831002739 protein binding site [polypeptide binding]; other site 649831002740 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 649831002741 Coenzyme A binding pocket [chemical binding]; other site 649831002742 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 649831002743 putative active site; other site 649831002744 putative metal binding residues [ion binding]; other site 649831002745 signature motif; other site 649831002746 putative triphosphate binding site [ion binding]; other site 649831002747 CHAD domain; Region: CHAD; pfam05235 649831002748 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 649831002749 ribonuclease Z; Reviewed; Region: PRK00055 649831002750 methionine sulfoxide reductase A; Provisional; Region: PRK00058 649831002751 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 649831002752 nucleotide binding site/active site [active] 649831002753 HIT family signature motif; other site 649831002754 catalytic residue [active] 649831002755 cystathionine gamma-synthase; Provisional; Region: PRK07811 649831002756 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 649831002757 homodimer interface [polypeptide binding]; other site 649831002758 substrate-cofactor binding pocket; other site 649831002759 pyridoxal 5'-phosphate binding site [chemical binding]; other site 649831002760 catalytic residue [active] 649831002761 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 649831002762 Amidase; Region: Amidase; cl11426 649831002763 threonine dehydratase; Provisional; Region: PRK08198 649831002764 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 649831002765 tetramer interface [polypeptide binding]; other site 649831002766 pyridoxal 5'-phosphate binding site [chemical binding]; other site 649831002767 catalytic residue [active] 649831002768 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 649831002769 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 649831002770 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 649831002771 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 649831002772 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 649831002773 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 649831002774 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 649831002775 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 649831002776 metal binding site [ion binding]; metal-binding site 649831002777 active site 649831002778 I-site; other site 649831002779 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 649831002780 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 649831002781 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 649831002782 catalytic residues [active] 649831002783 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 649831002784 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 649831002785 active site 649831002786 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 649831002787 ATP-grasp domain; Region: ATP-grasp_4; cl17255 649831002788 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 649831002789 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 649831002790 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 649831002791 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 649831002792 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 649831002793 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 649831002794 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 649831002795 active site 649831002796 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 649831002797 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 649831002798 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 649831002799 acyl-activating enzyme (AAE) consensus motif; other site 649831002800 putative AMP binding site [chemical binding]; other site 649831002801 putative active site [active] 649831002802 putative CoA binding site [chemical binding]; other site 649831002803 glycosyl hydrolase 64 family; Region: GH64-like; cd09214 649831002804 substrate binding pocket [chemical binding]; other site 649831002805 catalytic residues [active] 649831002806 TIGR03089 family protein; Region: TIGR03089 649831002807 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 649831002808 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 649831002809 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 649831002810 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 649831002811 Substrate binding site; other site 649831002812 Cupin domain; Region: Cupin_2; cl17218 649831002813 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 649831002814 nudix motif; other site 649831002815 GTP and metal dependent enzyme involved F420 coenzyme biosynthesis (catalyzes addition of two l-glutamates to F420 precursor) [Coenzyme transport and metabolism]; Region: COG1478 649831002816 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996 649831002817 LPPG:FO 2-phospho-L-lactate transferase; Provisional; Region: PRK13606 649831002818 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 649831002819 phosphate binding site [ion binding]; other site 649831002820 dimer interface [polypeptide binding]; other site 649831002821 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 649831002822 FO synthase; Reviewed; Region: fbiC; PRK09234 649831002823 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 649831002824 FeS/SAM binding site; other site 649831002825 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 649831002826 FeS/SAM binding site; other site 649831002827 Transcription factor WhiB; Region: Whib; pfam02467 649831002828 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 649831002829 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 649831002830 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 649831002831 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 649831002832 NodB motif; other site 649831002833 active site 649831002834 catalytic site [active] 649831002835 metal binding site [ion binding]; metal-binding site 649831002836 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 649831002837 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 649831002838 NAD(P) binding site [chemical binding]; other site 649831002839 catalytic residues [active] 649831002840 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 649831002841 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 649831002842 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 649831002843 NAD(P) binding site [chemical binding]; other site 649831002844 catalytic residues [active] 649831002845 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649831002846 S-adenosylmethionine binding site [chemical binding]; other site 649831002847 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 649831002848 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 649831002849 Protein of unknown function (DUF3455); Region: DUF3455; pfam11937 649831002850 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 649831002851 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 649831002852 active site 649831002853 substrate binding site [chemical binding]; other site 649831002854 metal binding site [ion binding]; metal-binding site 649831002855 Uncharacterized conserved protein [Function unknown]; Region: COG2835 649831002856 bifunctional phosphoglucose/phosphomannose isomerase; Region: G6PI_arch; TIGR02128 649831002857 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 649831002858 The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_2; cd05637 649831002859 dimer interface [polypeptide binding]; other site 649831002860 active site 649831002861 Cation efflux family; Region: Cation_efflux; pfam01545 649831002862 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 649831002863 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 649831002864 Domain of unknown function (DUF397); Region: DUF397; pfam04149 649831002865 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 649831002866 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831002867 active site 649831002868 phosphorylation site [posttranslational modification] 649831002869 intermolecular recognition site; other site 649831002870 dimerization interface [polypeptide binding]; other site 649831002871 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 649831002872 DNA binding site [nucleotide binding] 649831002873 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 649831002874 dimerization interface [polypeptide binding]; other site 649831002875 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 649831002876 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 649831002877 dimer interface [polypeptide binding]; other site 649831002878 phosphorylation site [posttranslational modification] 649831002879 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831002880 ATP binding site [chemical binding]; other site 649831002881 Mg2+ binding site [ion binding]; other site 649831002882 G-X-G motif; other site 649831002883 lipoprotein LpqB; Provisional; Region: PRK13616 649831002884 Sporulation and spore germination; Region: Germane; pfam10646 649831002885 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 649831002886 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 649831002887 active site 649831002888 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 649831002889 30S subunit binding site; other site 649831002890 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 649831002891 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 649831002892 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 649831002893 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 649831002894 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 649831002895 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 649831002896 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 649831002897 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 649831002898 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 649831002899 nucleotide binding region [chemical binding]; other site 649831002900 SEC-C motif; Region: SEC-C; pfam02810 649831002901 Helix-turn-helix domain; Region: HTH_17; pfam12728 649831002902 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 649831002903 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 649831002904 putative DNA binding site [nucleotide binding]; other site 649831002905 putative Zn2+ binding site [ion binding]; other site 649831002906 AsnC family; Region: AsnC_trans_reg; pfam01037 649831002907 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 649831002908 active site residue [active] 649831002909 peptide chain release factor 2; Validated; Region: prfB; PRK00578 649831002910 This domain is found in peptide chain release factors; Region: PCRF; smart00937 649831002911 RF-1 domain; Region: RF-1; pfam00472 649831002912 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 649831002913 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649831002914 Walker A/P-loop; other site 649831002915 ATP binding site [chemical binding]; other site 649831002916 Q-loop/lid; other site 649831002917 ABC transporter signature motif; other site 649831002918 Walker B; other site 649831002919 D-loop; other site 649831002920 H-loop/switch region; other site 649831002921 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 649831002922 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 649831002923 FtsX-like permease family; Region: FtsX; pfam02687 649831002924 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 649831002925 Peptidase family M23; Region: Peptidase_M23; pfam01551 649831002926 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 649831002927 SmpB-tmRNA interface; other site 649831002928 Cellulose binding domain; Region: CBM_2; cl17741 649831002929 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 649831002930 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 649831002931 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 649831002932 generic binding surface II; other site 649831002933 generic binding surface I; other site 649831002934 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 649831002935 putative active site [active] 649831002936 putative catalytic site [active] 649831002937 putative Mg binding site IVb [ion binding]; other site 649831002938 putative phosphate binding site [ion binding]; other site 649831002939 putative DNA binding site [nucleotide binding]; other site 649831002940 putative Mg binding site IVa [ion binding]; other site 649831002941 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 649831002942 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 649831002943 active site 649831002944 metal binding site [ion binding]; metal-binding site 649831002945 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 649831002946 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 649831002947 hypothetical protein; Validated; Region: PRK00228 649831002948 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 649831002949 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 649831002950 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 649831002951 Transcriptional regulators [Transcription]; Region: GntR; COG1802 649831002952 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 649831002953 DNA-binding site [nucleotide binding]; DNA binding site 649831002954 FCD domain; Region: FCD; pfam07729 649831002955 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 649831002956 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 649831002957 putative sugar binding sites [chemical binding]; other site 649831002958 Q-X-W motif; other site 649831002959 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cl15820 649831002960 putative sugar binding sites [chemical binding]; other site 649831002961 Q-X-W motif; other site 649831002962 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 649831002963 Prokaryotic N-terminal methylation site; Region: N_methyl_3; pfam13633 649831002964 Pilus assembly protein, PilO; Region: PilO; cl01234 649831002965 Competence protein A; Region: Competence_A; pfam11104 649831002966 Cell division protein FtsA; Region: FtsA; cl17206 649831002967 Cell division protein FtsA; Region: FtsA; pfam14450 649831002968 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 649831002969 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 649831002970 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 649831002971 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 649831002972 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 649831002973 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 649831002974 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 649831002975 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 649831002976 Walker A motif; other site 649831002977 ATP binding site [chemical binding]; other site 649831002978 Walker B motif; other site 649831002979 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 649831002980 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 649831002981 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 649831002982 Walker A motif; other site 649831002983 ATP binding site [chemical binding]; other site 649831002984 Walker B motif; other site 649831002985 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 649831002986 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 649831002987 conserved cys residue [active] 649831002988 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 649831002989 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 649831002990 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831002991 putative substrate translocation pore; other site 649831002992 Major Facilitator Superfamily; Region: MFS_1; pfam07690 649831002993 Streptomyces extracellular neutral proteinase (M7) family; Region: Peptidase_M7; pfam02031 649831002994 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 649831002995 Interdomain contacts; other site 649831002996 Cytokine receptor motif; other site 649831002997 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 649831002998 Interdomain contacts; other site 649831002999 Cytokine receptor motif; other site 649831003000 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 649831003001 Interdomain contacts; other site 649831003002 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 649831003003 Interdomain contacts; other site 649831003004 Cytokine receptor motif; other site 649831003005 Tetratricopeptide repeat; Region: TPR_12; pfam13424 649831003006 Tetratricopeptide repeat; Region: TPR_12; pfam13424 649831003007 Tetratricopeptide repeat; Region: TPR_10; pfam13374 649831003008 Tetratricopeptide repeat; Region: TPR_12; pfam13424 649831003009 Tetratricopeptide repeat; Region: TPR_12; pfam13424 649831003010 Tetratricopeptide repeat; Region: TPR_10; pfam13374 649831003011 Tetratricopeptide repeat; Region: TPR_12; pfam13424 649831003012 Tetratricopeptide repeat; Region: TPR_10; pfam13374 649831003013 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 649831003014 metal binding site [ion binding]; metal-binding site 649831003015 active site 649831003016 I-site; other site 649831003017 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 649831003018 HEXXH motif domain; Region: mod_HExxH; TIGR04267 649831003019 Domain of unknown function (DUF427); Region: DUF427; pfam04248 649831003020 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 649831003021 GAF domain; Region: GAF; pfam01590 649831003022 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 649831003023 GAF domain; Region: GAF; cl17456 649831003024 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 649831003025 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 649831003026 polymerase nucleotide-binding site; other site 649831003027 DNA-binding residues [nucleotide binding]; DNA binding site 649831003028 nucleotide binding site [chemical binding]; other site 649831003029 primase nucleotide-binding site [nucleotide binding]; other site 649831003030 Beta protein; Region: Beta_protein; pfam14350 649831003031 Part of AAA domain; Region: AAA_19; pfam13245 649831003032 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 649831003033 putative FMN binding site [chemical binding]; other site 649831003034 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 649831003035 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 649831003036 Transcriptional regulators [Transcription]; Region: GntR; COG1802 649831003037 DNA-binding site [nucleotide binding]; DNA binding site 649831003038 FCD domain; Region: FCD; pfam07729 649831003039 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 649831003040 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 649831003041 Na binding site [ion binding]; other site 649831003042 putative substrate binding site [chemical binding]; other site 649831003043 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 649831003044 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831003045 active site 649831003046 RibD C-terminal domain; Region: RibD_C; cl17279 649831003047 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 649831003048 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 649831003049 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 649831003050 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 649831003051 Beta-lactamase; Region: Beta-lactamase; pfam00144 649831003052 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 649831003053 Walker A motif; other site 649831003054 ATP binding site [chemical binding]; other site 649831003055 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 649831003056 AAA domain; Region: AAA_12; pfam13087 649831003057 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 649831003058 putative active site [active] 649831003059 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 649831003060 conserved cys residue [active] 649831003061 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 649831003062 PAS domain; Region: PAS_9; pfam13426 649831003063 putative active site [active] 649831003064 heme pocket [chemical binding]; other site 649831003065 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 649831003066 I-site; other site 649831003067 active site 649831003068 metal binding site [ion binding]; metal-binding site 649831003069 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 649831003070 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 649831003071 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 649831003072 MarR family; Region: MarR_2; cl17246 649831003073 Repair protein; Region: Repair_PSII; pfam04536 649831003074 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 649831003075 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 649831003076 NAD binding site [chemical binding]; other site 649831003077 catalytic Zn binding site [ion binding]; other site 649831003078 substrate binding site [chemical binding]; other site 649831003079 structural Zn binding site [ion binding]; other site 649831003080 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 649831003081 alpha-glucosidase; Provisional; Region: PRK10137 649831003082 Trehalase; Region: Trehalase; cl17346 649831003083 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 649831003084 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 649831003085 active site 649831003086 DNA binding site [nucleotide binding] 649831003087 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 649831003088 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 649831003089 FAD binding domain; Region: FAD_binding_3; pfam01494 649831003090 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 649831003091 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 649831003092 D-pathway; other site 649831003093 Putative ubiquinol binding site [chemical binding]; other site 649831003094 Low-spin heme (heme b) binding site [chemical binding]; other site 649831003095 Putative water exit pathway; other site 649831003096 Binuclear center (heme o3/CuB) [ion binding]; other site 649831003097 K-pathway; other site 649831003098 Putative proton exit pathway; other site 649831003099 Major Facilitator Superfamily; Region: MFS_1; pfam07690 649831003100 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831003101 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 649831003102 Isochorismatase family; Region: Isochorismatase; pfam00857 649831003103 catalytic triad [active] 649831003104 conserved cis-peptide bond; other site 649831003105 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 649831003106 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 649831003107 active site 649831003108 AAA ATPase domain; Region: AAA_16; pfam13191 649831003109 AAA domain; Region: AAA_22; pfam13401 649831003110 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649831003111 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649831003112 DNA binding residues [nucleotide binding] 649831003113 dimerization interface [polypeptide binding]; other site 649831003114 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 649831003115 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 649831003116 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 649831003117 active site 649831003118 catalytic tetrad [active] 649831003119 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 649831003120 MPN+ (JAMM) motif; other site 649831003121 Zinc-binding site [ion binding]; other site 649831003122 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 649831003123 MoaE interaction surface [polypeptide binding]; other site 649831003124 MoeB interaction surface [polypeptide binding]; other site 649831003125 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 649831003126 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 649831003127 dimer interface [polypeptide binding]; other site 649831003128 pyridoxal 5'-phosphate binding site [chemical binding]; other site 649831003129 catalytic residue [active] 649831003130 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 649831003131 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 649831003132 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 649831003133 Ribonuclease PH; Region: RNase_PH_bact; cd11362 649831003134 ribonuclease PH; Reviewed; Region: rph; PRK00173 649831003135 hexamer interface [polypeptide binding]; other site 649831003136 active site 649831003137 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 649831003138 active site 649831003139 dimerization interface [polypeptide binding]; other site 649831003140 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 649831003141 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 649831003142 Transcriptional regulators [Transcription]; Region: MarR; COG1846 649831003143 MarR family; Region: MarR; pfam01047 649831003144 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 649831003145 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 649831003146 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 649831003147 DNA binding residues [nucleotide binding] 649831003148 YCII-related domain; Region: YCII; cl00999 649831003149 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 649831003150 active sites [active] 649831003151 tetramer interface [polypeptide binding]; other site 649831003152 imidazolonepropionase; Provisional; Region: PRK14085 649831003153 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 649831003154 active site 649831003155 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 649831003156 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 649831003157 active site 649831003158 allantoate amidohydrolase; Reviewed; Region: PRK09290 649831003159 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 649831003160 active site 649831003161 metal binding site [ion binding]; metal-binding site 649831003162 dimer interface [polypeptide binding]; other site 649831003163 urocanate hydratase; Provisional; Region: PRK05414 649831003164 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 649831003165 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 649831003166 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 649831003167 hypothetical protein; Reviewed; Region: PRK09588 649831003168 Uncharacterized protein family UPF0027; Region: UPF0027; cl17455 649831003169 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 649831003170 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 649831003171 MOSC domain; Region: MOSC; pfam03473 649831003172 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 649831003173 Endoglucanase C-terminal domain/subunit and related proteins [Carbohydrate transport and metabolism]; Region: COG4305 649831003174 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 649831003175 active site 649831003176 Homeodomain-like domain; Region: HTH_23; cl17451 649831003177 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 649831003178 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 649831003179 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 649831003180 dimerization interface [polypeptide binding]; other site 649831003181 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 649831003182 dimer interface [polypeptide binding]; other site 649831003183 putative CheW interface [polypeptide binding]; other site 649831003184 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 649831003185 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 649831003186 catalytic triad [active] 649831003187 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 649831003188 catalytic residues [active] 649831003189 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 649831003190 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 649831003191 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 649831003192 DNA binding residues [nucleotide binding] 649831003193 CopC domain; Region: CopC; pfam04234 649831003194 Copper resistance protein D; Region: CopD; cl00563 649831003195 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 649831003196 putative active site [active] 649831003197 putative substrate binding site [chemical binding]; other site 649831003198 dimer interface [polypeptide binding]; other site 649831003199 catalytic site [active] 649831003200 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 649831003201 hypothetical protein; Provisional; Region: PRK07236 649831003202 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831003203 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831003204 Catalytic NodB homology domain of Streptomyces lividans acetylxylan esterase and its bacterial homologs; Region: CE4_SlAXE_like; cd10953 649831003205 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 649831003206 NodB motif; other site 649831003207 active site 649831003208 catalytic site [active] 649831003209 Zn binding site [ion binding]; other site 649831003210 dimer interface [polypeptide binding]; other site 649831003211 CBD_II domain; Region: CBD_II; smart00637 649831003212 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 649831003213 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831003214 putative substrate translocation pore; other site 649831003215 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 649831003216 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831003217 Alpha-L-arabinofuranosidase B, catalytic; Region: ArabFuran-catal; pfam09206 649831003218 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 649831003219 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 649831003220 putative sugar binding sites [chemical binding]; other site 649831003221 Q-X-W motif; other site 649831003222 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cl15820 649831003223 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 649831003224 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 649831003225 ATP binding site [chemical binding]; other site 649831003226 Mg2+ binding site [ion binding]; other site 649831003227 G-X-G motif; other site 649831003228 GAF domain; Region: GAF; cl17456 649831003229 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 649831003230 PAS fold; Region: PAS_4; pfam08448 649831003231 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 649831003232 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 649831003233 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 649831003234 ATP binding site [chemical binding]; other site 649831003235 Mg2+ binding site [ion binding]; other site 649831003236 G-X-G motif; other site 649831003237 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 649831003238 anti sigma factor interaction site; other site 649831003239 regulatory phosphorylation site [posttranslational modification]; other site 649831003240 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 649831003241 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 649831003242 putative NAD(P) binding site [chemical binding]; other site 649831003243 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 649831003244 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 649831003245 RHS Repeat; Region: RHS_repeat; pfam05593 649831003246 RHS Repeat; Region: RHS_repeat; pfam05593 649831003247 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 649831003248 RHS Repeat; Region: RHS_repeat; pfam05593 649831003249 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 649831003250 RHS Repeat; Region: RHS_repeat; cl11982 649831003251 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 649831003252 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 649831003253 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 649831003254 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 649831003255 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 649831003256 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 649831003257 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 649831003258 Bacterial Ig-like domain; Region: Big_5; pfam13205 649831003259 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 649831003260 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 649831003261 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 649831003262 PRC-barrel domain; Region: PRC; pfam05239 649831003263 Response regulator receiver domain; Region: Response_reg; pfam00072 649831003264 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831003265 active site 649831003266 phosphorylation site [posttranslational modification] 649831003267 intermolecular recognition site; other site 649831003268 dimerization interface [polypeptide binding]; other site 649831003269 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 649831003270 Transglycosylase; Region: Transgly; pfam00912 649831003271 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 649831003272 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 649831003273 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 649831003274 NodB motif; other site 649831003275 active site 649831003276 catalytic site [active] 649831003277 metal binding site [ion binding]; metal-binding site 649831003278 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 649831003279 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 649831003280 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 649831003281 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 649831003282 ATP binding site [chemical binding]; other site 649831003283 Walker A motif; other site 649831003284 hexamer interface [polypeptide binding]; other site 649831003285 Walker B motif; other site 649831003286 Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963 649831003287 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 649831003288 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 649831003289 Flp/Fap pilin component; Region: Flp_Fap; cl01585 649831003290 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 649831003291 Protein of unknown function (DUF2000); Region: DUF2000; cl02074 649831003292 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 649831003293 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 649831003294 putative DNA binding site [nucleotide binding]; other site 649831003295 putative Zn2+ binding site [ion binding]; other site 649831003296 AsnC family; Region: AsnC_trans_reg; pfam01037 649831003297 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 649831003298 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 649831003299 Coenzyme A binding pocket [chemical binding]; other site 649831003300 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 649831003301 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 649831003302 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 649831003303 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 649831003304 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 649831003305 oligomer interface [polypeptide binding]; other site 649831003306 metal binding site [ion binding]; metal-binding site 649831003307 metal binding site [ion binding]; metal-binding site 649831003308 putative Cl binding site [ion binding]; other site 649831003309 basic sphincter; other site 649831003310 hydrophobic gate; other site 649831003311 periplasmic entrance; other site 649831003312 Predicted transcriptional regulator [Transcription]; Region: COG2378 649831003313 HTH domain; Region: HTH_11; pfam08279 649831003314 WYL domain; Region: WYL; pfam13280 649831003315 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 649831003316 active site 649831003317 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 649831003318 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 649831003319 Mg2+ binding site [ion binding]; other site 649831003320 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 649831003321 putative DNA binding site [nucleotide binding]; other site 649831003322 putative Zn2+ binding site [ion binding]; other site 649831003323 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893 649831003324 putative hydrophobic ligand binding site [chemical binding]; other site 649831003325 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 649831003326 A subgroup of the Glycosyl hydrolase family 20 (GH20) catalytic domain found in proteins similar to the N-acetylhexosaminidase from Streptomyces plicatus (SpHex). SpHex catalyzes the hydrolysis of N-acetyl-beta-hexosaminides. An Asp residue within the...; Region: GH20_SpHex_like; cd06568 649831003327 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 649831003328 active site 649831003329 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 649831003330 Cytochrome P450; Region: p450; cl12078 649831003331 Nitrate and nitrite sensing; Region: NIT; pfam08376 649831003332 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 649831003333 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831003334 ATP binding site [chemical binding]; other site 649831003335 Mg2+ binding site [ion binding]; other site 649831003336 G-X-G motif; other site 649831003337 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 649831003338 Protein of unknown function (DUF742); Region: DUF742; pfam05331 649831003339 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 649831003340 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 649831003341 G1 box; other site 649831003342 GTP/Mg2+ binding site [chemical binding]; other site 649831003343 G2 box; other site 649831003344 Switch I region; other site 649831003345 G3 box; other site 649831003346 Switch II region; other site 649831003347 G5 box; other site 649831003348 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 649831003349 DNA binding site [nucleotide binding] 649831003350 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 649831003351 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 649831003352 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 649831003353 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 649831003354 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 649831003355 metal ion-dependent adhesion site (MIDAS); other site 649831003356 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 649831003357 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 649831003358 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 649831003359 MarR family; Region: MarR_2; pfam12802 649831003360 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 649831003361 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 649831003362 xylose isomerase, Arthrobacter type; Region: xylA_Arthro; TIGR02631 649831003363 xylose isomerase; Provisional; Region: PRK12677 649831003364 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 649831003365 D-xylulose kinase; Region: XylB; TIGR01312 649831003366 nucleotide binding site [chemical binding]; other site 649831003367 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 649831003368 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 649831003369 active site 649831003370 catalytic site [active] 649831003371 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 649831003372 HD domain; Region: HD_4; pfam13328 649831003373 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 649831003374 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 649831003375 Predicted phosphoesterases, related to the Icc protein [General function prediction only]; Region: COG2129 649831003376 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 649831003377 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 649831003378 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 649831003379 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 649831003380 TMP-binding site; other site 649831003381 ATP-binding site [chemical binding]; other site 649831003382 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 649831003383 classical (c) SDRs; Region: SDR_c; cd05233 649831003384 NAD(P) binding site [chemical binding]; other site 649831003385 active site 649831003386 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 649831003387 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 649831003388 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 649831003389 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 649831003390 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 649831003391 DNA binding residues [nucleotide binding] 649831003392 NlpC/P60 family; Region: NLPC_P60; pfam00877 649831003393 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 649831003394 BCCT family transporter; Region: BCCT; cl00569 649831003395 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 649831003396 ANTAR domain; Region: ANTAR; pfam03861 649831003397 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 649831003398 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831003399 putative substrate translocation pore; other site 649831003400 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 649831003401 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 649831003402 putative DNA binding site [nucleotide binding]; other site 649831003403 putative Zn2+ binding site [ion binding]; other site 649831003404 Predicted methyltransferase [General function prediction only]; Region: COG3897 649831003405 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 649831003406 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649831003407 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831003408 active site 649831003409 phosphorylation site [posttranslational modification] 649831003410 intermolecular recognition site; other site 649831003411 dimerization interface [polypeptide binding]; other site 649831003412 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649831003413 DNA binding residues [nucleotide binding] 649831003414 dimerization interface [polypeptide binding]; other site 649831003415 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 649831003416 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 649831003417 ligand binding site [chemical binding]; other site 649831003418 NAD binding site [chemical binding]; other site 649831003419 tetramer interface [polypeptide binding]; other site 649831003420 catalytic site [active] 649831003421 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 649831003422 L-serine binding site [chemical binding]; other site 649831003423 ACT domain interface; other site 649831003424 Phosphotransferase enzyme family; Region: APH; pfam01636 649831003425 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 649831003426 active site 649831003427 ATP binding site [chemical binding]; other site 649831003428 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 649831003429 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 649831003430 Predicted transcriptional regulators [Transcription]; Region: COG1695 649831003431 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 649831003432 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 649831003433 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 649831003434 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 649831003435 Coenzyme A binding pocket [chemical binding]; other site 649831003436 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 649831003437 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 649831003438 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 649831003439 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 649831003440 dimer interface [polypeptide binding]; other site 649831003441 ssDNA binding site [nucleotide binding]; other site 649831003442 tetramer (dimer of dimers) interface [polypeptide binding]; other site 649831003443 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 649831003444 cobyric acid synthase; Provisional; Region: PRK00784 649831003445 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 649831003446 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 649831003447 catalytic triad [active] 649831003448 hypothetical protein; Provisional; Region: PRK06547 649831003449 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 649831003450 hypothetical protein; Provisional; Region: PRK07907 649831003451 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 649831003452 active site 649831003453 metal binding site [ion binding]; metal-binding site 649831003454 dimer interface [polypeptide binding]; other site 649831003455 FAD binding domain; Region: FAD_binding_3; pfam01494 649831003456 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 649831003457 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 649831003458 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 649831003459 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015 649831003460 active site 649831003461 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015 649831003462 active site 649831003463 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 649831003464 DNA binding site [nucleotide binding] 649831003465 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 649831003466 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 649831003467 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 649831003468 conserved cys residue [active] 649831003469 TIGR03086 family protein; Region: TIGR03086 649831003470 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 649831003471 Transglycosylase; Region: Transgly; pfam00912 649831003472 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 649831003473 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 649831003474 hypothetical protein; Provisional; Region: PRK07908 649831003475 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 649831003476 pyridoxal 5'-phosphate binding site [chemical binding]; other site 649831003477 homodimer interface [polypeptide binding]; other site 649831003478 catalytic residue [active] 649831003479 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 649831003480 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 649831003481 putative dimer interface [polypeptide binding]; other site 649831003482 active site pocket [active] 649831003483 putative cataytic base [active] 649831003484 siroheme synthase; Provisional; Region: cysG; PRK10637 649831003485 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 649831003486 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 649831003487 active site 649831003488 SAM binding site [chemical binding]; other site 649831003489 homodimer interface [polypeptide binding]; other site 649831003490 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 649831003491 active site 649831003492 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 649831003493 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 649831003494 active site 649831003495 homotetramer interface [polypeptide binding]; other site 649831003496 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 649831003497 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 649831003498 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 649831003499 ABC transporter; Region: ABC_tran_2; pfam12848 649831003500 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 649831003501 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 649831003502 active site 649831003503 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 649831003504 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 649831003505 apolar tunnel; other site 649831003506 heme binding site [chemical binding]; other site 649831003507 dimerization interface [polypeptide binding]; other site 649831003508 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831003509 Major Facilitator Superfamily; Region: MFS_1; pfam07690 649831003510 putative substrate translocation pore; other site 649831003511 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 649831003512 Mechanosensitive ion channel; Region: MS_channel; pfam00924 649831003513 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 649831003514 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 649831003515 active site 649831003516 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 649831003517 active site 649831003518 putative catalytic site [active] 649831003519 Predicted membrane protein [Function unknown]; Region: COG1470 649831003520 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 649831003521 putative active site [active] 649831003522 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 649831003523 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 649831003524 Zn binding site [ion binding]; other site 649831003525 Uncharacterized conserved protein [Function unknown]; Region: COG4198 649831003526 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 649831003527 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 649831003528 substrate binding pocket [chemical binding]; other site 649831003529 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 649831003530 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 649831003531 hypothetical protein; Provisional; Region: PRK01346 649831003532 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 649831003533 Coenzyme A binding pocket [chemical binding]; other site 649831003534 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 649831003535 hydrophobic ligand binding site; other site 649831003536 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 649831003537 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 649831003538 DNA binding site [nucleotide binding] 649831003539 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 649831003540 NB-ARC domain; Region: NB-ARC; pfam00931 649831003541 Tetratricopeptide repeat; Region: TPR_12; pfam13424 649831003542 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 649831003543 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 649831003544 active site 649831003545 oxidoreductase; Provisional; Region: PRK06128 649831003546 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 649831003547 NAD binding site [chemical binding]; other site 649831003548 metal binding site [ion binding]; metal-binding site 649831003549 active site 649831003550 Dihydroorotase and related cyclic amidohydrolases [Nucleotide transport and metabolism]; Region: PyrC; COG0044 649831003551 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 649831003552 active site 649831003553 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 649831003554 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 649831003555 NB-ARC domain; Region: NB-ARC; pfam00931 649831003556 Tetratricopeptide repeat; Region: TPR_12; pfam13424 649831003557 Tetratricopeptide repeat; Region: TPR_12; pfam13424 649831003558 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 649831003559 TPR motif; other site 649831003560 Tetratricopeptide repeat; Region: TPR_12; pfam13424 649831003561 binding surface 649831003562 Tetratricopeptide repeat; Region: TPR_12; pfam13424 649831003563 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 649831003564 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649831003565 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649831003566 DNA binding residues [nucleotide binding] 649831003567 dimerization interface [polypeptide binding]; other site 649831003568 YqcI/YcgG family; Region: YqcI_YcgG; cl01349 649831003569 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 649831003570 motif 1; other site 649831003571 dimer interface [polypeptide binding]; other site 649831003572 active site 649831003573 motif 2; other site 649831003574 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 649831003575 motif 1; other site 649831003576 dimer interface [polypeptide binding]; other site 649831003577 active site 649831003578 motif 2; other site 649831003579 motif 3; other site 649831003580 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649831003581 S-adenosylmethionine binding site [chemical binding]; other site 649831003582 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 649831003583 Major Facilitator Superfamily; Region: MFS_1; pfam07690 649831003584 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 649831003585 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 649831003586 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831003587 NAD(P) binding site [chemical binding]; other site 649831003588 active site 649831003589 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649831003590 S-adenosylmethionine binding site [chemical binding]; other site 649831003591 FkbH-like domain; Region: FkbH; TIGR01686 649831003592 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 649831003593 active site 649831003594 motif I; other site 649831003595 motif II; other site 649831003596 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 649831003597 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 649831003598 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 649831003599 active site 649831003600 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 649831003601 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 649831003602 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 649831003603 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 649831003604 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831003605 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 649831003606 active site 649831003607 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 649831003608 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 649831003609 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 649831003610 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 649831003611 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 649831003612 acyl-activating enzyme (AAE) consensus motif; other site 649831003613 AMP binding site [chemical binding]; other site 649831003614 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 649831003615 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 649831003616 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 649831003617 PYR/PP interface [polypeptide binding]; other site 649831003618 dimer interface [polypeptide binding]; other site 649831003619 TPP binding site [chemical binding]; other site 649831003620 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 649831003621 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 649831003622 TPP-binding site [chemical binding]; other site 649831003623 dimer interface [polypeptide binding]; other site 649831003624 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 649831003625 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 649831003626 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 649831003627 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 649831003628 active site 649831003629 metal binding site [ion binding]; metal-binding site 649831003630 Subunit A of Class III extradiol dioxygenases; Region: Extradiol_Dioxygenase_3A_like; cl06673 649831003631 dimer interface [polypeptide binding]; other site 649831003632 tetramer interface [polypeptide binding]; other site 649831003633 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 649831003634 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 649831003635 homodimer interface [polypeptide binding]; other site 649831003636 substrate-cofactor binding pocket; other site 649831003637 pyridoxal 5'-phosphate binding site [chemical binding]; other site 649831003638 catalytic residue [active] 649831003639 Predicted transcriptional regulators [Transcription]; Region: COG1733 649831003640 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 649831003641 trigger factor; Provisional; Region: tig; PRK01490 649831003642 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 649831003643 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 649831003644 Clp protease; Region: CLP_protease; pfam00574 649831003645 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 649831003646 oligomer interface [polypeptide binding]; other site 649831003647 active site residues [active] 649831003648 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 649831003649 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 649831003650 oligomer interface [polypeptide binding]; other site 649831003651 active site residues [active] 649831003652 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 649831003653 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 649831003654 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 649831003655 Walker A motif; other site 649831003656 ATP binding site [chemical binding]; other site 649831003657 Walker B motif; other site 649831003658 arginine finger; other site 649831003659 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 649831003660 nitrilase; Region: PLN02798 649831003661 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 649831003662 putative active site [active] 649831003663 catalytic triad [active] 649831003664 dimer interface [polypeptide binding]; other site 649831003665 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 649831003666 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 649831003667 HIGH motif; other site 649831003668 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 649831003669 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 649831003670 active site 649831003671 KMSKS motif; other site 649831003672 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 649831003673 tRNA binding surface [nucleotide binding]; other site 649831003674 anticodon binding site; other site 649831003675 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 649831003676 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 649831003677 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 649831003678 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 649831003679 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 649831003680 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 649831003681 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 649831003682 active site 649831003683 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 649831003684 active site 649831003685 multimer interface [polypeptide binding]; other site 649831003686 PhoD-like phosphatase; Region: PhoD; pfam09423 649831003687 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 649831003688 putative active site [active] 649831003689 putative metal binding site [ion binding]; other site 649831003690 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 649831003691 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 649831003692 putative acyl-acceptor binding pocket; other site 649831003693 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 649831003694 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 649831003695 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK12323 649831003696 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 649831003697 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 649831003698 PAS domain; Region: PAS_9; pfam13426 649831003699 putative active site [active] 649831003700 heme pocket [chemical binding]; other site 649831003701 GAF domain; Region: GAF_3; pfam13492 649831003702 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 649831003703 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 649831003704 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 649831003705 ATP binding site [chemical binding]; other site 649831003706 Mg2+ binding site [ion binding]; other site 649831003707 G-X-G motif; other site 649831003708 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 649831003709 anti sigma factor interaction site; other site 649831003710 regulatory phosphorylation site [posttranslational modification]; other site 649831003711 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 649831003712 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 649831003713 B12 binding site [chemical binding]; other site 649831003714 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 649831003715 FeS/SAM binding site; other site 649831003716 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 649831003717 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 649831003718 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 649831003719 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 649831003720 homodimer interface [polypeptide binding]; other site 649831003721 oligonucleotide binding site [chemical binding]; other site 649831003722 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 649831003723 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 649831003724 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 649831003725 GTPase CgtA; Reviewed; Region: obgE; PRK12296 649831003726 GTP1/OBG; Region: GTP1_OBG; pfam01018 649831003727 Obg GTPase; Region: Obg; cd01898 649831003728 G1 box; other site 649831003729 GTP/Mg2+ binding site [chemical binding]; other site 649831003730 Switch I region; other site 649831003731 G2 box; other site 649831003732 G3 box; other site 649831003733 Switch II region; other site 649831003734 G4 box; other site 649831003735 G5 box; other site 649831003736 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 649831003737 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 649831003738 Coenzyme A binding pocket [chemical binding]; other site 649831003739 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 649831003740 putative sugar binding sites [chemical binding]; other site 649831003741 Ricin-type beta-trefoil; Region: RICIN; smart00458 649831003742 Q-X-W motif; other site 649831003743 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 649831003744 putative sugar binding sites [chemical binding]; other site 649831003745 Q-X-W motif; other site 649831003746 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 649831003747 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 649831003748 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 649831003749 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 649831003750 Zn binding site [ion binding]; other site 649831003751 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 649831003752 PAS domain; Region: PAS_8; pfam13188 649831003753 putative active site [active] 649831003754 heme pocket [chemical binding]; other site 649831003755 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 649831003756 dimer interface [polypeptide binding]; other site 649831003757 phosphorylation site [posttranslational modification] 649831003758 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831003759 ATP binding site [chemical binding]; other site 649831003760 Mg2+ binding site [ion binding]; other site 649831003761 G-X-G motif; other site 649831003762 Response regulator receiver domain; Region: Response_reg; pfam00072 649831003763 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831003764 active site 649831003765 phosphorylation site [posttranslational modification] 649831003766 intermolecular recognition site; other site 649831003767 dimerization interface [polypeptide binding]; other site 649831003768 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 649831003769 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 649831003770 active site 649831003771 (T/H)XGH motif; other site 649831003772 Oligomerisation domain; Region: Oligomerisation; pfam02410 649831003773 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 649831003774 catalytic core [active] 649831003775 EDD domain protein, DegV family; Region: DegV; TIGR00762 649831003776 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 649831003777 Protein of unknown function (DUF1444); Region: DUF1444; cl02011 649831003778 comEA protein; Region: comE; TIGR01259 649831003779 Competence protein; Region: Competence; pfam03772 649831003780 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 649831003781 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 649831003782 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831003783 NADH(P)-binding; Region: NAD_binding_10; pfam13460 649831003784 NAD(P) binding site [chemical binding]; other site 649831003785 active site 649831003786 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831003787 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831003788 NADH(P)-binding; Region: NAD_binding_10; pfam13460 649831003789 NAD(P) binding site [chemical binding]; other site 649831003790 active site 649831003791 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 649831003792 hypothetical protein; Reviewed; Region: PRK07914 649831003793 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 649831003794 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 649831003795 Protein of unknown function (DUF4240); Region: DUF4240; pfam14024 649831003796 molybdenum cofactor biosynthesis protein MoaC/MOSC-domain-containing protein; Provisional; Region: PRK14499 649831003797 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 649831003798 GTP-binding protein LepA; Provisional; Region: PRK05433 649831003799 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 649831003800 G1 box; other site 649831003801 putative GEF interaction site [polypeptide binding]; other site 649831003802 GTP/Mg2+ binding site [chemical binding]; other site 649831003803 Switch I region; other site 649831003804 G2 box; other site 649831003805 G3 box; other site 649831003806 Switch II region; other site 649831003807 G4 box; other site 649831003808 G5 box; other site 649831003809 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 649831003810 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 649831003811 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 649831003812 Predicted membrane protein [Function unknown]; Region: COG2261 649831003813 PAS domain S-box; Region: sensory_box; TIGR00229 649831003814 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 649831003815 putative active site [active] 649831003816 heme pocket [chemical binding]; other site 649831003817 enoyl-CoA hydratase; Provisional; Region: PRK07827 649831003818 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 649831003819 substrate binding site [chemical binding]; other site 649831003820 oxyanion hole (OAH) forming residues; other site 649831003821 trimer interface [polypeptide binding]; other site 649831003822 coproporphyrinogen III oxidase; Validated; Region: PRK05628 649831003823 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 649831003824 FeS/SAM binding site; other site 649831003825 Tic20-like protein; Region: Tic20; pfam09685 649831003826 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 649831003827 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 649831003828 chaperone protein DnaJ; Provisional; Region: PRK14278 649831003829 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 649831003830 HSP70 interaction site [polypeptide binding]; other site 649831003831 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 649831003832 Zn binding sites [ion binding]; other site 649831003833 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 649831003834 dimer interface [polypeptide binding]; other site 649831003835 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 649831003836 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 649831003837 conserved cys residue [active] 649831003838 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 649831003839 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 649831003840 RNA methyltransferase, RsmE family; Region: TIGR00046 649831003841 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 649831003842 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 649831003843 ABC-ATPase subunit interface; other site 649831003844 dimer interface [polypeptide binding]; other site 649831003845 putative PBP binding regions; other site 649831003846 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 649831003847 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 649831003848 ABC-ATPase subunit interface; other site 649831003849 dimer interface [polypeptide binding]; other site 649831003850 putative PBP binding regions; other site 649831003851 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 649831003852 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 649831003853 Walker A/P-loop; other site 649831003854 ATP binding site [chemical binding]; other site 649831003855 Q-loop/lid; other site 649831003856 ABC transporter signature motif; other site 649831003857 Walker B; other site 649831003858 D-loop; other site 649831003859 H-loop/switch region; other site 649831003860 MbtH-like protein; Region: MbtH; pfam03621 649831003861 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 649831003862 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 649831003863 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649831003864 Walker A/P-loop; other site 649831003865 ATP binding site [chemical binding]; other site 649831003866 Q-loop/lid; other site 649831003867 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649831003868 ABC transporter signature motif; other site 649831003869 Walker B; other site 649831003870 D-loop; other site 649831003871 H-loop/switch region; other site 649831003872 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 649831003873 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 649831003874 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649831003875 Walker A/P-loop; other site 649831003876 ATP binding site [chemical binding]; other site 649831003877 Q-loop/lid; other site 649831003878 ABC transporter signature motif; other site 649831003879 Walker B; other site 649831003880 D-loop; other site 649831003881 H-loop/switch region; other site 649831003882 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 649831003883 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 649831003884 acyl-activating enzyme (AAE) consensus motif; other site 649831003885 AMP binding site [chemical binding]; other site 649831003886 Condensation domain; Region: Condensation; pfam00668 649831003887 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 649831003888 Condensation domain; Region: Condensation; pfam00668 649831003889 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 649831003890 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 649831003891 acyl-activating enzyme (AAE) consensus motif; other site 649831003892 AMP binding site [chemical binding]; other site 649831003893 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 649831003894 Condensation domain; Region: Condensation; pfam00668 649831003895 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 649831003896 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 649831003897 acyl-activating enzyme (AAE) consensus motif; other site 649831003898 AMP binding site [chemical binding]; other site 649831003899 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 649831003900 Condensation domain; Region: Condensation; pfam00668 649831003901 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 649831003902 Condensation domain; Region: Condensation; pfam00668 649831003903 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 649831003904 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 649831003905 acyl-activating enzyme (AAE) consensus motif; other site 649831003906 AMP binding site [chemical binding]; other site 649831003907 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831003908 Condensation domain; Region: Condensation; pfam00668 649831003909 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 649831003910 Condensation domain; Region: Condensation; pfam00668 649831003911 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 649831003912 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 649831003913 acyl-activating enzyme (AAE) consensus motif; other site 649831003914 AMP binding site [chemical binding]; other site 649831003915 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 649831003916 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 649831003917 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 649831003918 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 649831003919 acyl-activating enzyme (AAE) consensus motif; other site 649831003920 AMP binding site [chemical binding]; other site 649831003921 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 649831003922 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 649831003923 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 649831003924 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 649831003925 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 649831003926 D-pathway; other site 649831003927 Putative ubiquinol binding site [chemical binding]; other site 649831003928 Low-spin heme (heme b) binding site [chemical binding]; other site 649831003929 Putative water exit pathway; other site 649831003930 Binuclear center (heme o3/CuB) [ion binding]; other site 649831003931 K-pathway; other site 649831003932 Putative proton exit pathway; other site 649831003933 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 649831003934 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 649831003935 siderophore binding site; other site 649831003936 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 649831003937 tetramerization interface [polypeptide binding]; other site 649831003938 active site 649831003939 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 649831003940 Helix-turn-helix domain; Region: HTH_31; pfam13560 649831003941 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 649831003942 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 649831003943 Coenzyme A binding pocket [chemical binding]; other site 649831003944 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 649831003945 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 649831003946 active site 649831003947 catalytic tetrad [active] 649831003948 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 649831003949 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 649831003950 active site 649831003951 substrate binding site [chemical binding]; other site 649831003952 cosubstrate binding site; other site 649831003953 catalytic site [active] 649831003954 Carboxy-terminal domain of Formyltransferase and similar domains; Region: FMT_C_like; cl14785 649831003955 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 649831003956 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 649831003957 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 649831003958 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 649831003959 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 649831003960 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 649831003961 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 649831003962 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 649831003963 classical (c) SDRs; Region: SDR_c; cd05233 649831003964 NAD(P) binding site [chemical binding]; other site 649831003965 active site 649831003966 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 649831003967 Beta-lactamase; Region: Beta-lactamase; pfam00144 649831003968 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 649831003969 PhoH-like protein; Region: PhoH; pfam02562 649831003970 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl17442 649831003971 Homing endonuclease; Region: Hom_end; pfam05204 649831003972 PhoH-like protein; Region: PhoH; pfam02562 649831003973 metal-binding heat shock protein; Provisional; Region: PRK00016 649831003974 Domain of unknown function DUF21; Region: DUF21; pfam01595 649831003975 FOG: CBS domain [General function prediction only]; Region: COG0517 649831003976 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 649831003977 Transporter associated domain; Region: CorC_HlyC; smart01091 649831003978 GTPase Era; Reviewed; Region: era; PRK00089 649831003979 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 649831003980 G1 box; other site 649831003981 GTP/Mg2+ binding site [chemical binding]; other site 649831003982 Switch I region; other site 649831003983 G2 box; other site 649831003984 Switch II region; other site 649831003985 G3 box; other site 649831003986 G4 box; other site 649831003987 G5 box; other site 649831003988 KH domain; Region: KH_2; pfam07650 649831003989 Acyltransferase family; Region: Acyl_transf_3; pfam01757 649831003990 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 649831003991 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 649831003992 Recombination protein O N terminal; Region: RecO_N; pfam11967 649831003993 Recombination protein O C terminal; Region: RecO_C; pfam02565 649831003994 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14829 649831003995 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 649831003996 catalytic residue [active] 649831003997 putative FPP diphosphate binding site; other site 649831003998 putative FPP binding hydrophobic cleft; other site 649831003999 dimer interface [polypeptide binding]; other site 649831004000 putative IPP diphosphate binding site; other site 649831004001 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 649831004002 catalytic core [active] 649831004003 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 649831004004 putative active site [active] 649831004005 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 649831004006 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 649831004007 active site 649831004008 YceI-like domain; Region: YceI; smart00867 649831004009 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 649831004010 TPR motif; other site 649831004011 binding surface 649831004012 Tetratricopeptide repeat; Region: TPR_16; pfam13432 649831004013 Domain of unknown function DUF77; Region: DUF77; pfam01910 649831004014 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 649831004015 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 649831004016 motif II; other site 649831004017 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 649831004018 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 649831004019 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 649831004020 non-specific DNA binding site [nucleotide binding]; other site 649831004021 salt bridge; other site 649831004022 sequence-specific DNA binding site [nucleotide binding]; other site 649831004023 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 649831004024 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 649831004025 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831004026 WHG domain; Region: WHG; pfam13305 649831004027 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 649831004028 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 649831004029 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 649831004030 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 649831004031 Walker A/P-loop; other site 649831004032 ATP binding site [chemical binding]; other site 649831004033 Q-loop/lid; other site 649831004034 ABC transporter signature motif; other site 649831004035 Walker B; other site 649831004036 D-loop; other site 649831004037 H-loop/switch region; other site 649831004038 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 649831004039 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 649831004040 Walker A/P-loop; other site 649831004041 ATP binding site [chemical binding]; other site 649831004042 Q-loop/lid; other site 649831004043 ABC transporter signature motif; other site 649831004044 Walker B; other site 649831004045 D-loop; other site 649831004046 H-loop/switch region; other site 649831004047 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 649831004048 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 649831004049 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 649831004050 metal binding site 2 [ion binding]; metal-binding site 649831004051 putative DNA binding helix; other site 649831004052 metal binding site 1 [ion binding]; metal-binding site 649831004053 dimer interface [polypeptide binding]; other site 649831004054 structural Zn2+ binding site [ion binding]; other site 649831004055 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 649831004056 dimerization interface [polypeptide binding]; other site 649831004057 putative DNA binding site [nucleotide binding]; other site 649831004058 putative Zn2+ binding site [ion binding]; other site 649831004059 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 649831004060 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 649831004061 dimer interface [polypeptide binding]; other site 649831004062 putative PBP binding regions; other site 649831004063 ABC-ATPase subunit interface; other site 649831004064 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 649831004065 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 649831004066 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 649831004067 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 649831004068 metal binding site [ion binding]; metal-binding site 649831004069 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 649831004070 glycyl-tRNA synthetase; Provisional; Region: PRK04173 649831004071 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 649831004072 motif 1; other site 649831004073 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 649831004074 active site 649831004075 motif 2; other site 649831004076 motif 3; other site 649831004077 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 649831004078 anticodon binding site; other site 649831004079 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 649831004080 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 649831004081 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 649831004082 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 649831004083 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 649831004084 dimer interface [polypeptide binding]; other site 649831004085 phosphorylation site [posttranslational modification] 649831004086 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831004087 ATP binding site [chemical binding]; other site 649831004088 Mg2+ binding site [ion binding]; other site 649831004089 G-X-G motif; other site 649831004090 AAA domain; Region: AAA_22; pfam13401 649831004091 AAA ATPase domain; Region: AAA_16; pfam13191 649831004092 Integrase core domain; Region: rve; pfam00665 649831004093 Integrase core domain; Region: rve_3; cl15866 649831004094 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 649831004095 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 649831004096 multiple promoter invertase; Provisional; Region: mpi; PRK13413 649831004097 catalytic residues [active] 649831004098 catalytic nucleophile [active] 649831004099 Presynaptic Site I dimer interface [polypeptide binding]; other site 649831004100 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 649831004101 Synaptic Flat tetramer interface [polypeptide binding]; other site 649831004102 Synaptic Site I dimer interface [polypeptide binding]; other site 649831004103 DNA binding site [nucleotide binding] 649831004104 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 649831004105 DNA-binding interface [nucleotide binding]; DNA binding site 649831004106 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 649831004107 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 649831004108 XdhC Rossmann domain; Region: XdhC_C; pfam13478 649831004109 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 649831004110 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 649831004111 FMN binding site [chemical binding]; other site 649831004112 active site 649831004113 catalytic residues [active] 649831004114 substrate binding site [chemical binding]; other site 649831004115 NIPSNAP; Region: NIPSNAP; pfam07978 649831004116 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 649831004117 RibD C-terminal domain; Region: RibD_C; cl17279 649831004118 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 649831004119 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 649831004120 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 649831004121 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 649831004122 active site 649831004123 metal binding site [ion binding]; metal-binding site 649831004124 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 649831004125 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 649831004126 Zn2+ binding site [ion binding]; other site 649831004127 Mg2+ binding site [ion binding]; other site 649831004128 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 649831004129 DNA primase; Validated; Region: dnaG; PRK05667 649831004130 CHC2 zinc finger; Region: zf-CHC2; pfam01807 649831004131 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 649831004132 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 649831004133 active site 649831004134 metal binding site [ion binding]; metal-binding site 649831004135 interdomain interaction site; other site 649831004136 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 649831004137 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 649831004138 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 649831004139 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649831004140 Walker A/P-loop; other site 649831004141 ATP binding site [chemical binding]; other site 649831004142 Q-loop/lid; other site 649831004143 ABC transporter signature motif; other site 649831004144 Walker B; other site 649831004145 D-loop; other site 649831004146 H-loop/switch region; other site 649831004147 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 649831004148 ABC-2 type transporter; Region: ABC2_membrane; cl17235 649831004149 ABC-2 type transporter; Region: ABC2_membrane; cl17235 649831004150 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 649831004151 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 649831004152 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 649831004153 Transcriptional regulators [Transcription]; Region: MarR; COG1846 649831004154 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 649831004155 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 649831004156 nucleotide binding site [chemical binding]; other site 649831004157 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 649831004158 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 649831004159 Walker A/P-loop; other site 649831004160 ATP binding site [chemical binding]; other site 649831004161 Q-loop/lid; other site 649831004162 ABC transporter signature motif; other site 649831004163 Walker B; other site 649831004164 D-loop; other site 649831004165 H-loop/switch region; other site 649831004166 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 649831004167 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 649831004168 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 649831004169 TM-ABC transporter signature motif; other site 649831004170 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 649831004171 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 649831004172 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 649831004173 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 649831004174 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 649831004175 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 649831004176 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 649831004177 Metal-binding active site; metal-binding site 649831004178 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 649831004179 Competence protein CoiA-like family; Region: CoiA; cl11541 649831004180 Divergent AAA domain; Region: AAA_4; pfam04326 649831004181 SnoaL-like domain; Region: SnoaL_2; pfam12680 649831004182 Predicted transcriptional regulator [Transcription]; Region: COG2378 649831004183 HTH domain; Region: HTH_11; pfam08279 649831004184 WYL domain; Region: WYL; pfam13280 649831004185 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 649831004186 substrate binding site [chemical binding]; other site 649831004187 Helix-turn-helix domain; Region: HTH_31; pfam13560 649831004188 Transcriptional regulator [Transcription]; Region: LysR; COG0583 649831004189 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 649831004190 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 649831004191 dimerization interface [polypeptide binding]; other site 649831004192 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 649831004193 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831004194 NAD(P) binding site [chemical binding]; other site 649831004195 active site 649831004196 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 649831004197 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 649831004198 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 649831004199 putative DNA binding site [nucleotide binding]; other site 649831004200 putative Zn2+ binding site [ion binding]; other site 649831004201 AsnC family; Region: AsnC_trans_reg; pfam01037 649831004202 putative transporter; Provisional; Region: PRK11021 649831004203 Transcriptional regulator [Transcription]; Region: LysR; COG0583 649831004204 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 649831004205 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 649831004206 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 649831004207 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 649831004208 active site 649831004209 DNA binding site [nucleotide binding] 649831004210 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 649831004211 DNA binding site [nucleotide binding] 649831004212 short chain dehydrogenase; Provisional; Region: PRK06179 649831004213 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 649831004214 NADP binding site [chemical binding]; other site 649831004215 active site 649831004216 steroid binding site; other site 649831004217 NACHT domain; Region: NACHT; pfam05729 649831004218 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 649831004219 hypothetical protein; Provisional; Region: PRK07588 649831004220 hypothetical protein; Provisional; Region: PRK07236 649831004221 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 649831004222 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831004223 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 649831004224 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 649831004225 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 649831004226 non-specific DNA binding site [nucleotide binding]; other site 649831004227 salt bridge; other site 649831004228 sequence-specific DNA binding site [nucleotide binding]; other site 649831004229 Domain of unknown function (DUF955); Region: DUF955; cl01076 649831004230 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405 649831004231 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 649831004232 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 649831004233 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 649831004234 DNA binding site [nucleotide binding] 649831004235 Peptidase S8 family domain in BacillopeptidaseF-like proteins; Region: Peptidases_S8_BacillopeptidaseF-like; cd07481 649831004236 active site 649831004237 catalytic triad [active] 649831004238 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 649831004239 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 649831004240 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 649831004241 Kelch domain; Region: Kelch; smart00612 649831004242 Kelch motif; Region: Kelch_1; pfam01344 649831004243 Kelch motif; Region: Kelch_1; pfam01344 649831004244 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 649831004245 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 649831004246 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 649831004247 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 649831004248 active site 649831004249 metal binding site [ion binding]; metal-binding site 649831004250 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 649831004251 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 649831004252 NAD binding site [chemical binding]; other site 649831004253 Glycosyl hydrolase family 43, includes mostly 1,4-beta-xylanases; Region: GH43_bXyl; cd09004 649831004254 putative substrate binding site [chemical binding]; other site 649831004255 active site 649831004256 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 649831004257 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 649831004258 active site 649831004259 catalytic residues [active] 649831004260 Flavoprotein; Region: Flavoprotein; pfam02441 649831004261 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 649831004262 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 649831004263 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 649831004264 hydrophobic ligand binding site; other site 649831004265 Protein of unknown function (DUF2283); Region: DUF2283; pfam10049 649831004266 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 649831004267 dimer interface [polypeptide binding]; other site 649831004268 putative CheW interface [polypeptide binding]; other site 649831004269 PilZ domain; Region: PilZ; pfam07238 649831004270 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 649831004271 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 649831004272 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 649831004273 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 649831004274 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 649831004275 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 649831004276 active site 649831004277 HIGH motif; other site 649831004278 KMSK motif region; other site 649831004279 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 649831004280 tRNA binding surface [nucleotide binding]; other site 649831004281 anticodon binding site; other site 649831004282 RDD family; Region: RDD; pfam06271 649831004283 Integral membrane protein DUF95; Region: DUF95; pfam01944 649831004284 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 649831004285 sequence-specific DNA binding site [nucleotide binding]; other site 649831004286 salt bridge; other site 649831004287 Haemolytic domain; Region: Haemolytic; pfam01809 649831004288 BioY family; Region: BioY; pfam02632 649831004289 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 649831004290 Protein of unknown function DUF58; Region: DUF58; pfam01882 649831004291 MoxR-like ATPases [General function prediction only]; Region: COG0714 649831004292 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 649831004293 Walker A motif; other site 649831004294 ATP binding site [chemical binding]; other site 649831004295 Walker B motif; other site 649831004296 arginine finger; other site 649831004297 Domain of unknown function DUF87; Region: DUF87; pfam01935 649831004298 AAA-like domain; Region: AAA_10; pfam12846 649831004299 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 649831004300 FOG: WD40 repeat [General function prediction only]; Region: COG2319 649831004301 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 649831004302 structural tetrad; other site 649831004303 FOG: WD40 repeat [General function prediction only]; Region: COG2319 649831004304 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 649831004305 structural tetrad; other site 649831004306 2',3'-cyclic-nucleotide 2'-phosphodiesterase; Region: CycNucDiestase; TIGR01390 649831004307 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 649831004308 active site 649831004309 metal binding site [ion binding]; metal-binding site 649831004310 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 649831004311 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 649831004312 Catalytic domain of Protein Kinases; Region: PKc; cd00180 649831004313 active site 649831004314 ATP binding site [chemical binding]; other site 649831004315 substrate binding site [chemical binding]; other site 649831004316 activation loop (A-loop); other site 649831004317 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 649831004318 anti sigma factor interaction site; other site 649831004319 regulatory phosphorylation site [posttranslational modification]; other site 649831004320 Survival protein SurE; Region: SurE; cl00448 649831004321 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 649831004322 substrate binding site [chemical binding]; other site 649831004323 ATP binding site [chemical binding]; other site 649831004324 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 649831004325 Family description; Region: UvrD_C_2; pfam13538 649831004326 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 649831004327 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 649831004328 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 649831004329 active site clefts [active] 649831004330 zinc binding site [ion binding]; other site 649831004331 dimer interface [polypeptide binding]; other site 649831004332 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 649831004333 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 649831004334 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 649831004335 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 649831004336 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 649831004337 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831004338 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 649831004339 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 649831004340 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831004341 NAD(P) binding site [chemical binding]; other site 649831004342 active site 649831004343 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831004344 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 649831004345 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 649831004346 dimer interface [polypeptide binding]; other site 649831004347 active site 649831004348 acyl carrier protein; Provisional; Region: acpP; PRK00982 649831004349 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 649831004350 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 649831004351 dimer interface [polypeptide binding]; other site 649831004352 active site 649831004353 CoA binding pocket [chemical binding]; other site 649831004354 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 649831004355 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 649831004356 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 649831004357 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 649831004358 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831004359 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 649831004360 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 649831004361 DNA binding residues [nucleotide binding] 649831004362 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 649831004363 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 649831004364 active site 649831004365 HIGH motif; other site 649831004366 nucleotide binding site [chemical binding]; other site 649831004367 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 649831004368 active site 649831004369 KMSKS motif; other site 649831004370 Cupin; Region: Cupin_6; pfam12852 649831004371 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 649831004372 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 649831004373 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 649831004374 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 649831004375 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 649831004376 active site 649831004377 Major Facilitator Superfamily; Region: MFS_1; pfam07690 649831004378 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831004379 RibD C-terminal domain; Region: RibD_C; cl17279 649831004380 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 649831004381 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 649831004382 dimer interface [polypeptide binding]; other site 649831004383 putative CheW interface [polypeptide binding]; other site 649831004384 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 649831004385 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 649831004386 dimer interface [polypeptide binding]; other site 649831004387 TPP-binding site [chemical binding]; other site 649831004388 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 649831004389 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 649831004390 TPP-binding site [chemical binding]; other site 649831004391 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 649831004392 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 649831004393 PYR/PP interface [polypeptide binding]; other site 649831004394 dimer interface [polypeptide binding]; other site 649831004395 TPP binding site [chemical binding]; other site 649831004396 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 649831004397 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 649831004398 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 649831004399 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 649831004400 dimer interface [polypeptide binding]; other site 649831004401 catalytic triad [active] 649831004402 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 649831004403 CBD_II domain; Region: CBD_II; smart00637 649831004404 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 649831004405 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 649831004406 Cellulose binding domain; Region: CBM_2; pfam00553 649831004407 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 649831004408 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 649831004409 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831004410 Domain of unknown function (DUF4281); Region: DUF4281; pfam14108 649831004411 Histidine kinase; Region: HisKA_3; pfam07730 649831004412 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649831004413 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831004414 active site 649831004415 phosphorylation site [posttranslational modification] 649831004416 intermolecular recognition site; other site 649831004417 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649831004418 DNA binding residues [nucleotide binding] 649831004419 dimerization interface [polypeptide binding]; other site 649831004420 YCII-related domain; Region: YCII; cl00999 649831004421 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 649831004422 Bifunctional DNA primase/polymerase, N-terminal; Region: Prim-Pol; smart00943 649831004423 nucleotide binding site [chemical binding]; other site 649831004424 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 649831004425 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 649831004426 non-specific DNA binding site [nucleotide binding]; other site 649831004427 salt bridge; other site 649831004428 sequence-specific DNA binding site [nucleotide binding]; other site 649831004429 Flavoprotein; Region: Flavoprotein; pfam02441 649831004430 Uncharacterized conserved protein [Function unknown]; Region: COG0327 649831004431 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 649831004432 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 649831004433 Putative zinc ribbon domain; Region: DUF164; pfam02591 649831004434 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 649831004435 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 649831004436 RNA/DNA hybrid binding site [nucleotide binding]; other site 649831004437 active site 649831004438 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 649831004439 catalytic core [active] 649831004440 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 649831004441 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 649831004442 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 649831004443 MarR family; Region: MarR; pfam01047 649831004444 MarR family; Region: MarR_2; cl17246 649831004445 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 649831004446 Na binding site [ion binding]; other site 649831004447 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 649831004448 Glyco_18 domain; Region: Glyco_18; smart00636 649831004449 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 649831004450 active site 649831004451 Nucleotidyltransferase domain; Region: NTP_transf_2; pfam01909 649831004452 metal binding triad [ion binding]; metal-binding site 649831004453 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 649831004454 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 649831004455 catalytic residue [active] 649831004456 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 649831004457 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 649831004458 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 649831004459 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 649831004460 putative deacylase active site [active] 649831004461 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 649831004462 EamA-like transporter family; Region: EamA; pfam00892 649831004463 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 649831004464 sequence-specific DNA binding site [nucleotide binding]; other site 649831004465 salt bridge; other site 649831004466 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649831004467 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831004468 active site 649831004469 phosphorylation site [posttranslational modification] 649831004470 intermolecular recognition site; other site 649831004471 dimerization interface [polypeptide binding]; other site 649831004472 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649831004473 DNA binding residues [nucleotide binding] 649831004474 dimerization interface [polypeptide binding]; other site 649831004475 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 649831004476 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 649831004477 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 649831004478 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 649831004479 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 649831004480 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 649831004481 substrate binding site [chemical binding]; other site 649831004482 ATP binding site [chemical binding]; other site 649831004483 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 649831004484 S-adenosylmethionine synthetase; Validated; Region: PRK05250 649831004485 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 649831004486 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 649831004487 Adenosylhomocysteinase; Provisional; Region: PTZ00075 649831004488 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 649831004489 homotetramer interface [polypeptide binding]; other site 649831004490 ligand binding site [chemical binding]; other site 649831004491 catalytic site [active] 649831004492 NAD binding site [chemical binding]; other site 649831004493 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 649831004494 threonine dehydratase; Provisional; Region: PRK08246 649831004495 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 649831004496 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 649831004497 catalytic residue [active] 649831004498 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 649831004499 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 649831004500 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 649831004501 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 649831004502 dimerization interface [polypeptide binding]; other site 649831004503 active site 649831004504 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 649831004505 Methyltransferase domain; Region: Methyltransf_31; pfam13847 649831004506 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649831004507 S-adenosylmethionine binding site [chemical binding]; other site 649831004508 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 649831004509 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 649831004510 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 649831004511 RNB domain; Region: RNB; pfam00773 649831004512 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 649831004513 Zeta-crystallin with NADP-dependent quinone reductase activity (QOR); Region: zeta_crystallin; cd08253 649831004514 NAD(P) binding site [chemical binding]; other site 649831004515 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 649831004516 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 649831004517 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 649831004518 oligomerization interface [polypeptide binding]; other site 649831004519 active site 649831004520 metal binding site [ion binding]; metal-binding site 649831004521 NAD synthetase; Provisional; Region: PRK13981 649831004522 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 649831004523 multimer interface [polypeptide binding]; other site 649831004524 active site 649831004525 catalytic triad [active] 649831004526 protein interface 1 [polypeptide binding]; other site 649831004527 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 649831004528 homodimer interface [polypeptide binding]; other site 649831004529 NAD binding pocket [chemical binding]; other site 649831004530 ATP binding pocket [chemical binding]; other site 649831004531 Mg binding site [ion binding]; other site 649831004532 active-site loop [active] 649831004533 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 649831004534 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 649831004535 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 649831004536 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 649831004537 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 649831004538 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 649831004539 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 649831004540 Coenzyme A binding pocket [chemical binding]; other site 649831004541 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 649831004542 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 649831004543 catalytic triad [active] 649831004544 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 649831004545 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 649831004546 metal binding triad; other site 649831004547 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 649831004548 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 649831004549 metal binding triad; other site 649831004550 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 649831004551 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 649831004552 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 649831004553 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 649831004554 active site 649831004555 substrate binding site [chemical binding]; other site 649831004556 ATP binding site [chemical binding]; other site 649831004557 Phosphotransferase enzyme family; Region: APH; pfam01636 649831004558 Predicted transcriptional regulators [Transcription]; Region: COG1733 649831004559 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 649831004560 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 649831004561 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 649831004562 putative NAD(P) binding site [chemical binding]; other site 649831004563 glutamine synthetase, type I; Region: GlnA; TIGR00653 649831004564 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 649831004565 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 649831004566 RDD family; Region: RDD; pfam06271 649831004567 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 649831004568 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 649831004569 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 649831004570 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 649831004571 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 649831004572 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 649831004573 active site 649831004574 catalytic tetrad [active] 649831004575 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 649831004576 lipoyl synthase; Provisional; Region: PRK05481 649831004577 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 649831004578 FeS/SAM binding site; other site 649831004579 aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159 649831004580 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 649831004581 Dimer interface [polypeptide binding]; other site 649831004582 anticodon binding site; other site 649831004583 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 649831004584 motif 1; other site 649831004585 dimer interface [polypeptide binding]; other site 649831004586 active site 649831004587 motif 2; other site 649831004588 motif 3; other site 649831004589 Predicted membrane protein [General function prediction only]; Region: COG4194 649831004590 lipoate-protein ligase B; Provisional; Region: PRK14345 649831004591 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 649831004592 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 649831004593 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831004594 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 649831004595 NAD(P) binding site [chemical binding]; other site 649831004596 active site 649831004597 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase; Region: SucB_Actino; TIGR02927 649831004598 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 649831004599 E3 interaction surface; other site 649831004600 lipoyl attachment site [posttranslational modification]; other site 649831004601 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 649831004602 E3 interaction surface; other site 649831004603 lipoyl attachment site [posttranslational modification]; other site 649831004604 e3 binding domain; Region: E3_binding; pfam02817 649831004605 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 649831004606 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 649831004607 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 649831004608 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 649831004609 multifunctional aminopeptidase A; Provisional; Region: PRK00913 649831004610 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 649831004611 interface (dimer of trimers) [polypeptide binding]; other site 649831004612 Substrate-binding/catalytic site; other site 649831004613 Zn-binding sites [ion binding]; other site 649831004614 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 649831004615 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 649831004616 cobalamin synthase; Reviewed; Region: cobS; PRK00235 649831004617 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 649831004618 homotrimer interface [polypeptide binding]; other site 649831004619 Walker A motif; other site 649831004620 GTP binding site [chemical binding]; other site 649831004621 Walker B motif; other site 649831004622 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cl11435 649831004623 active site pocket [active] 649831004624 putative cataytic base [active] 649831004625 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 649831004626 Peptidase family M50; Region: Peptidase_M50; pfam02163 649831004627 active site 649831004628 putative substrate binding region [chemical binding]; other site 649831004629 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 649831004630 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 649831004631 active site 649831004632 catalytic tetrad [active] 649831004633 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 649831004634 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 649831004635 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 649831004636 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 649831004637 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649831004638 Walker A/P-loop; other site 649831004639 ATP binding site [chemical binding]; other site 649831004640 Q-loop/lid; other site 649831004641 ABC transporter signature motif; other site 649831004642 Walker B; other site 649831004643 D-loop; other site 649831004644 H-loop/switch region; other site 649831004645 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 649831004646 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 649831004647 sequence-specific DNA binding site [nucleotide binding]; other site 649831004648 salt bridge; other site 649831004649 Cupin domain; Region: Cupin_2; cl17218 649831004650 AzlC protein; Region: AzlC; cl00570 649831004651 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 649831004652 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 649831004653 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 649831004654 hinge; other site 649831004655 active site 649831004656 quinolinate synthetase; Provisional; Region: PRK09375 649831004657 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 649831004658 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 649831004659 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 649831004660 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 649831004661 substrate binding site [chemical binding]; other site 649831004662 ATP binding site [chemical binding]; other site 649831004663 AAA domain; Region: AAA_33; pfam13671 649831004664 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 649831004665 CPxP motif; other site 649831004666 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 649831004667 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 649831004668 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 649831004669 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 649831004670 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 649831004671 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 649831004672 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 649831004673 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 649831004674 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 649831004675 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 649831004676 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 649831004677 Subunit I/III interface [polypeptide binding]; other site 649831004678 Cytochrome c; Region: Cytochrom_C; pfam00034 649831004679 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 649831004680 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 649831004681 IncA protein; Region: IncA; pfam04156 649831004682 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 649831004683 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 649831004684 iron-sulfur cluster [ion binding]; other site 649831004685 [2Fe-2S] cluster binding site [ion binding]; other site 649831004686 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 649831004687 heme bH binding site [chemical binding]; other site 649831004688 Qi binding site; other site 649831004689 intrachain domain interface; other site 649831004690 heme bL binding site [chemical binding]; other site 649831004691 interchain domain interface [polypeptide binding]; other site 649831004692 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 649831004693 Qo binding site; other site 649831004694 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 649831004695 AsnC family; Region: AsnC_trans_reg; pfam01037 649831004696 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 649831004697 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 649831004698 active site 649831004699 NUDIX domain; Region: NUDIX; pfam00293 649831004700 nudix motif; other site 649831004701 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 649831004702 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 649831004703 Zn2+ binding site [ion binding]; other site 649831004704 Mg2+ binding site [ion binding]; other site 649831004705 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 649831004706 synthetase active site [active] 649831004707 NTP binding site [chemical binding]; other site 649831004708 metal binding site [ion binding]; metal-binding site 649831004709 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 649831004710 hypothetical protein; Validated; Region: PRK07883 649831004711 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 649831004712 active site 649831004713 catalytic site [active] 649831004714 substrate binding site [chemical binding]; other site 649831004715 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 649831004716 GIY-YIG motif/motif A; other site 649831004717 active site 649831004718 catalytic site [active] 649831004719 putative DNA binding site [nucleotide binding]; other site 649831004720 metal binding site [ion binding]; metal-binding site 649831004721 YacP-like NYN domain; Region: NYN_YacP; cl01491 649831004722 Peptidase family M48; Region: Peptidase_M48; cl12018 649831004723 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 649831004724 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 649831004725 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 649831004726 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649831004727 Walker A/P-loop; other site 649831004728 ATP binding site [chemical binding]; other site 649831004729 Q-loop/lid; other site 649831004730 ABC transporter signature motif; other site 649831004731 Walker B; other site 649831004732 D-loop; other site 649831004733 H-loop/switch region; other site 649831004734 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 649831004735 catalytic residues [active] 649831004736 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 649831004737 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 649831004738 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 649831004739 putative catalytic site [active] 649831004740 putative metal binding site [ion binding]; other site 649831004741 putative phosphate binding site [ion binding]; other site 649831004742 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 649831004743 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 649831004744 nucleotide binding site [chemical binding]; other site 649831004745 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 649831004746 putative hydrophobic ligand binding site [chemical binding]; other site 649831004747 GAF domain; Region: GAF_3; pfam13492 649831004748 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 649831004749 Histidine kinase; Region: HisKA_3; pfam07730 649831004750 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831004751 ATP binding site [chemical binding]; other site 649831004752 Mg2+ binding site [ion binding]; other site 649831004753 G-X-G motif; other site 649831004754 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649831004755 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831004756 active site 649831004757 phosphorylation site [posttranslational modification] 649831004758 intermolecular recognition site; other site 649831004759 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649831004760 DNA binding residues [nucleotide binding] 649831004761 dimerization interface [polypeptide binding]; other site 649831004762 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 649831004763 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 649831004764 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 649831004765 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 649831004766 active site 649831004767 homotetramer interface [polypeptide binding]; other site 649831004768 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 649831004769 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 649831004770 putative acyl-acceptor binding pocket; other site 649831004771 Phosphotransferase enzyme family; Region: APH; pfam01636 649831004772 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 649831004773 active site 649831004774 ATP binding site [chemical binding]; other site 649831004775 substrate binding site [chemical binding]; other site 649831004776 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 649831004777 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 649831004778 ligand binding site [chemical binding]; other site 649831004779 flexible hinge region; other site 649831004780 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 649831004781 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 649831004782 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 649831004783 phosphofructokinase; Region: PFK_mixed; TIGR02483 649831004784 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 649831004785 active site 649831004786 ADP/pyrophosphate binding site [chemical binding]; other site 649831004787 dimerization interface [polypeptide binding]; other site 649831004788 allosteric effector site; other site 649831004789 fructose-1,6-bisphosphate binding site; other site 649831004790 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 649831004791 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 649831004792 Protein of unknown function (DUF429); Region: DUF429; pfam04250 649831004793 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 649831004794 aromatic chitin/cellulose binding site residues [chemical binding]; other site 649831004795 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 649831004796 Glyco_18 domain; Region: Glyco_18; smart00636 649831004797 active site 649831004798 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 649831004799 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 649831004800 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 649831004801 tetramer interface [polypeptide binding]; other site 649831004802 pyridoxal 5'-phosphate binding site [chemical binding]; other site 649831004803 catalytic residue [active] 649831004804 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 649831004805 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831004806 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 649831004807 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 649831004808 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831004809 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 649831004810 Coenzyme A binding pocket [chemical binding]; other site 649831004811 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 649831004812 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 649831004813 Erythromycin esterase; Region: Erythro_esteras; cl17110 649831004814 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 649831004815 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 649831004816 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 649831004817 dimerization interface [polypeptide binding]; other site 649831004818 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 649831004819 putative Iron-sulfur protein interface [polypeptide binding]; other site 649831004820 proximal heme binding site [chemical binding]; other site 649831004821 distal heme binding site [chemical binding]; other site 649831004822 putative dimer interface [polypeptide binding]; other site 649831004823 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 649831004824 L-aspartate oxidase; Provisional; Region: PRK06175 649831004825 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 649831004826 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 649831004827 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 649831004828 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 649831004829 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 649831004830 Septum formation; Region: Septum_form; pfam13845 649831004831 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 649831004832 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831004833 H+ Antiporter protein; Region: 2A0121; TIGR00900 649831004834 MarR family; Region: MarR_2; pfam12802 649831004835 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 649831004836 HNH endonuclease; Region: HNH; pfam01844 649831004837 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 649831004838 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 649831004839 FAD binding site [chemical binding]; other site 649831004840 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 649831004841 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 649831004842 substrate binding pocket [chemical binding]; other site 649831004843 chain length determination region; other site 649831004844 substrate-Mg2+ binding site; other site 649831004845 catalytic residues [active] 649831004846 aspartate-rich region 1; other site 649831004847 active site lid residues [active] 649831004848 aspartate-rich region 2; other site 649831004849 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 649831004850 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 649831004851 Helix-turn-helix domain; Region: HTH_17; pfam12728 649831004852 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 649831004853 Catalytic domain of Protein Kinases; Region: PKc; cd00180 649831004854 active site 649831004855 ATP binding site [chemical binding]; other site 649831004856 substrate binding site [chemical binding]; other site 649831004857 activation loop (A-loop); other site 649831004858 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 649831004859 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 649831004860 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 649831004861 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 649831004862 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 649831004863 AP endonuclease family 2; Region: AP2Ec; smart00518 649831004864 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 649831004865 AP (apurinic/apyrimidinic) site pocket; other site 649831004866 DNA interaction; other site 649831004867 Metal-binding active site; metal-binding site 649831004868 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 649831004869 hydrophobic ligand binding site; other site 649831004870 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 649831004871 phytoene desaturase; Region: crtI_fam; TIGR02734 649831004872 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 649831004873 active site 649831004874 Protein of unknown function (DUF422); Region: DUF422; cl00991 649831004875 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 649831004876 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 649831004877 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 649831004878 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 649831004879 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 649831004880 Protein of unknown function DUF72; Region: DUF72; pfam01904 649831004881 GAF domain; Region: GAF; cl17456 649831004882 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 649831004883 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 649831004884 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 649831004885 Histidine kinase; Region: HisKA_3; pfam07730 649831004886 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831004887 ATP binding site [chemical binding]; other site 649831004888 Mg2+ binding site [ion binding]; other site 649831004889 G-X-G motif; other site 649831004890 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649831004891 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831004892 active site 649831004893 phosphorylation site [posttranslational modification] 649831004894 intermolecular recognition site; other site 649831004895 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649831004896 DNA binding residues [nucleotide binding] 649831004897 dimerization interface [polypeptide binding]; other site 649831004898 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831004899 active site 649831004900 phosphorylation site [posttranslational modification] 649831004901 intermolecular recognition site; other site 649831004902 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 649831004903 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 649831004904 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 649831004905 Amino acid permease; Region: AA_permease_2; pfam13520 649831004906 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831004907 NAD(P) binding site [chemical binding]; other site 649831004908 active site 649831004909 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 649831004910 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 649831004911 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 649831004912 FAD binding pocket [chemical binding]; other site 649831004913 FAD binding motif [chemical binding]; other site 649831004914 phosphate binding motif [ion binding]; other site 649831004915 beta-alpha-beta structure motif; other site 649831004916 NAD binding pocket [chemical binding]; other site 649831004917 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 649831004918 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831004919 short chain dehydrogenase; Provisional; Region: PRK06523 649831004920 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831004921 NAD(P) binding site [chemical binding]; other site 649831004922 active site 649831004923 DNA Polymerase Y-family; Region: PolY_like; cd03468 649831004924 DNA binding site [nucleotide binding] 649831004925 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 649831004926 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 649831004927 active site 649831004928 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 649831004929 generic binding surface II; other site 649831004930 generic binding surface I; other site 649831004931 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 649831004932 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 649831004933 Uncharacterized conserved protein [Function unknown]; Region: COG3379 649831004934 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 649831004935 active site 649831004936 DNA polymerase IV; Validated; Region: PRK02406 649831004937 DNA binding site [nucleotide binding] 649831004938 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 649831004939 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; cl17722 649831004940 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 649831004941 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 649831004942 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 649831004943 Protein of unknown function DUF58; Region: DUF58; pfam01882 649831004944 MoxR-like ATPases [General function prediction only]; Region: COG0714 649831004945 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 649831004946 Walker A motif; other site 649831004947 ATP binding site [chemical binding]; other site 649831004948 Walker B motif; other site 649831004949 arginine finger; other site 649831004950 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 649831004951 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 649831004952 HIGH motif; other site 649831004953 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 649831004954 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 649831004955 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 649831004956 active site 649831004957 KMSKS motif; other site 649831004958 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 649831004959 tRNA binding surface [nucleotide binding]; other site 649831004960 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 649831004961 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 649831004962 hinge; other site 649831004963 active site 649831004964 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831004965 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 649831004966 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 649831004967 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 649831004968 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 649831004969 catalytic triad [active] 649831004970 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 649831004971 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 649831004972 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 649831004973 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 649831004974 NlpC/P60 family; Region: NLPC_P60; cl17555 649831004975 cell division protein MraZ; Reviewed; Region: PRK00326 649831004976 MraZ protein; Region: MraZ; pfam02381 649831004977 MraZ protein; Region: MraZ; pfam02381 649831004978 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 649831004979 MraW methylase family; Region: Methyltransf_5; cl17771 649831004980 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 649831004981 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 649831004982 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 649831004983 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 649831004984 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 649831004985 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 649831004986 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 649831004987 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 649831004988 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 649831004989 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 649831004990 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 649831004991 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 649831004992 Mg++ binding site [ion binding]; other site 649831004993 putative catalytic motif [active] 649831004994 putative substrate binding site [chemical binding]; other site 649831004995 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 649831004996 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 649831004997 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 649831004998 active site 649831004999 homodimer interface [polypeptide binding]; other site 649831005000 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 649831005001 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 649831005002 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 649831005003 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 649831005004 Cell division protein FtsQ; Region: FtsQ; pfam03799 649831005005 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 649831005006 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 649831005007 nucleotide binding site [chemical binding]; other site 649831005008 SulA interaction site; other site 649831005009 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 649831005010 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 649831005011 catalytic residue [active] 649831005012 Protein of unknown function (DUF552); Region: DUF552; pfam04472 649831005013 DivIVA protein; Region: DivIVA; pfam05103 649831005014 DivIVA domain; Region: DivI1A_domain; TIGR03544 649831005015 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 649831005016 Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594 649831005017 potassium/proton antiporter; Reviewed; Region: PRK05326 649831005018 TrkA-C domain; Region: TrkA_C; pfam02080 649831005019 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 649831005020 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 649831005021 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 649831005022 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 649831005023 RNA binding surface [nucleotide binding]; other site 649831005024 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 649831005025 active site 649831005026 AAA domain; Region: AAA_31; pfam13614 649831005027 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 649831005028 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 649831005029 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 649831005030 active site 649831005031 PHP Thumb interface [polypeptide binding]; other site 649831005032 metal binding site [ion binding]; metal-binding site 649831005033 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 649831005034 generic binding surface II; other site 649831005035 generic binding surface I; other site 649831005036 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 649831005037 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 649831005038 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 649831005039 NAD binding site [chemical binding]; other site 649831005040 dimerization interface [polypeptide binding]; other site 649831005041 product binding site; other site 649831005042 substrate binding site [chemical binding]; other site 649831005043 zinc binding site [ion binding]; other site 649831005044 catalytic residues [active] 649831005045 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 649831005046 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 649831005047 pyridoxal 5'-phosphate binding site [chemical binding]; other site 649831005048 homodimer interface [polypeptide binding]; other site 649831005049 catalytic residue [active] 649831005050 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 649831005051 putative active site pocket [active] 649831005052 4-fold oligomerization interface [polypeptide binding]; other site 649831005053 metal binding residues [ion binding]; metal-binding site 649831005054 3-fold/trimer interface [polypeptide binding]; other site 649831005055 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 649831005056 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 649831005057 putative active site [active] 649831005058 oxyanion strand; other site 649831005059 catalytic triad [active] 649831005060 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 649831005061 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 649831005062 catalytic residues [active] 649831005063 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 649831005064 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 649831005065 substrate binding site [chemical binding]; other site 649831005066 glutamase interaction surface [polypeptide binding]; other site 649831005067 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 649831005068 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 649831005069 dimerization interface [polypeptide binding]; other site 649831005070 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 649831005071 dimer interface [polypeptide binding]; other site 649831005072 phosphorylation site [posttranslational modification] 649831005073 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831005074 ATP binding site [chemical binding]; other site 649831005075 Mg2+ binding site [ion binding]; other site 649831005076 G-X-G motif; other site 649831005077 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 649831005078 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831005079 active site 649831005080 phosphorylation site [posttranslational modification] 649831005081 intermolecular recognition site; other site 649831005082 dimerization interface [polypeptide binding]; other site 649831005083 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 649831005084 DNA binding site [nucleotide binding] 649831005085 FMN-binding domain; Region: FMN_bind; cl01081 649831005086 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 649831005087 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 649831005088 FAD binding pocket [chemical binding]; other site 649831005089 FAD binding motif [chemical binding]; other site 649831005090 phosphate binding motif [ion binding]; other site 649831005091 beta-alpha-beta structure motif; other site 649831005092 NAD binding pocket [chemical binding]; other site 649831005093 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 649831005094 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 649831005095 DNA-binding site [nucleotide binding]; DNA binding site 649831005096 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 649831005097 pyridoxal 5'-phosphate binding site [chemical binding]; other site 649831005098 homodimer interface [polypeptide binding]; other site 649831005099 catalytic residue [active] 649831005100 RibD C-terminal domain; Region: RibD_C; cl17279 649831005101 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 649831005102 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 649831005103 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 649831005104 acyl-activating enzyme (AAE) consensus motif; other site 649831005105 putative AMP binding site [chemical binding]; other site 649831005106 putative active site [active] 649831005107 putative CoA binding site [chemical binding]; other site 649831005108 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 649831005109 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 649831005110 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 649831005111 calcium binding site 2 [ion binding]; other site 649831005112 active site 649831005113 catalytic triad [active] 649831005114 calcium binding site 1 [ion binding]; other site 649831005115 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 649831005116 dimerization interface [polypeptide binding]; other site 649831005117 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 649831005118 dimer interface [polypeptide binding]; other site 649831005119 phosphorylation site [posttranslational modification] 649831005120 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 649831005121 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831005122 active site 649831005123 phosphorylation site [posttranslational modification] 649831005124 intermolecular recognition site; other site 649831005125 dimerization interface [polypeptide binding]; other site 649831005126 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 649831005127 DNA binding site [nucleotide binding] 649831005128 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 649831005129 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 649831005130 DNA-binding site [nucleotide binding]; DNA binding site 649831005131 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 649831005132 pyridoxal 5'-phosphate binding site [chemical binding]; other site 649831005133 homodimer interface [polypeptide binding]; other site 649831005134 catalytic residue [active] 649831005135 TIGR03085 family protein; Region: TIGR03085 649831005136 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 649831005137 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 649831005138 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649831005139 Walker A/P-loop; other site 649831005140 ATP binding site [chemical binding]; other site 649831005141 Q-loop/lid; other site 649831005142 ABC transporter signature motif; other site 649831005143 Walker B; other site 649831005144 D-loop; other site 649831005145 H-loop/switch region; other site 649831005146 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 649831005147 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 649831005148 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649831005149 Walker A/P-loop; other site 649831005150 ATP binding site [chemical binding]; other site 649831005151 Q-loop/lid; other site 649831005152 ABC transporter signature motif; other site 649831005153 Walker B; other site 649831005154 D-loop; other site 649831005155 H-loop/switch region; other site 649831005156 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 649831005157 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 649831005158 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 649831005159 RNA binding surface [nucleotide binding]; other site 649831005160 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 649831005161 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 649831005162 Trp docking motif [polypeptide binding]; other site 649831005163 PQQ-like domain; Region: PQQ_2; pfam13360 649831005164 active site 649831005165 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 649831005166 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831005167 WHG domain; Region: WHG; pfam13305 649831005168 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 649831005169 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 649831005170 active site 649831005171 catalytic tetrad [active] 649831005172 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 649831005173 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831005174 CAAX protease self-immunity; Region: Abi; pfam02517 649831005175 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 649831005176 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 649831005177 putative sugar binding sites [chemical binding]; other site 649831005178 Q-X-W motif; other site 649831005179 Bulb-type mannose-specific lectin; Region: B_lectin; smart00108 649831005180 Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028 649831005181 dimerization interface [polypeptide binding]; other site 649831005182 mannose binding site [chemical binding]; other site 649831005183 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 649831005184 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 649831005185 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 649831005186 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 649831005187 putative NAD(P) binding site [chemical binding]; other site 649831005188 Transcriptional regulator [Transcription]; Region: LysR; COG0583 649831005189 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 649831005190 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 649831005191 dimerization interface [polypeptide binding]; other site 649831005192 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 649831005193 EF-hand domain pair; Region: EF_hand_5; pfam13499 649831005194 Ca2+ binding site [ion binding]; other site 649831005195 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 649831005196 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831005197 ABC-2 type transporter; Region: ABC2_membrane; cl17235 649831005198 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 649831005199 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 649831005200 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 649831005201 Walker A/P-loop; other site 649831005202 ATP binding site [chemical binding]; other site 649831005203 Q-loop/lid; other site 649831005204 ABC transporter signature motif; other site 649831005205 Walker B; other site 649831005206 D-loop; other site 649831005207 H-loop/switch region; other site 649831005208 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 649831005209 anthranilate synthase component I; Provisional; Region: PRK13571 649831005210 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 649831005211 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 649831005212 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; cl17850 649831005213 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 649831005214 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 649831005215 active site 649831005216 catalytic tetrad [active] 649831005217 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 649831005218 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 649831005219 active site 649831005220 ribulose/triose binding site [chemical binding]; other site 649831005221 phosphate binding site [ion binding]; other site 649831005222 substrate (anthranilate) binding pocket [chemical binding]; other site 649831005223 product (indole) binding pocket [chemical binding]; other site 649831005224 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 649831005225 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 649831005226 pyridoxal 5'-phosphate binding site [chemical binding]; other site 649831005227 catalytic residue [active] 649831005228 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 649831005229 substrate binding site [chemical binding]; other site 649831005230 active site 649831005231 catalytic residues [active] 649831005232 heterodimer interface [polypeptide binding]; other site 649831005233 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 649831005234 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 649831005235 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 649831005236 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 649831005237 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 649831005238 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 649831005239 active site 649831005240 dimer interface [polypeptide binding]; other site 649831005241 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 649831005242 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 649831005243 active site 649831005244 FMN binding site [chemical binding]; other site 649831005245 substrate binding site [chemical binding]; other site 649831005246 3Fe-4S cluster binding site [ion binding]; other site 649831005247 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 649831005248 domain interface; other site 649831005249 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 649831005250 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 649831005251 non-specific DNA binding site [nucleotide binding]; other site 649831005252 sequence-specific DNA binding site [nucleotide binding]; other site 649831005253 salt bridge; other site 649831005254 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 649831005255 pyruvate kinase; Provisional; Region: PRK06247 649831005256 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 649831005257 active site 649831005258 domain interfaces; other site 649831005259 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 649831005260 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 649831005261 active site 649831005262 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 649831005263 catalytic triad [active] 649831005264 dimer interface [polypeptide binding]; other site 649831005265 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 649831005266 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 649831005267 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831005268 active site 649831005269 phosphorylation site [posttranslational modification] 649831005270 intermolecular recognition site; other site 649831005271 dimerization interface [polypeptide binding]; other site 649831005272 ANTAR domain; Region: ANTAR; pfam03861 649831005273 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 649831005274 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 649831005275 dimerization interface [polypeptide binding]; other site 649831005276 ligand binding site [chemical binding]; other site 649831005277 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 649831005278 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 649831005279 TM-ABC transporter signature motif; other site 649831005280 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 649831005281 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 649831005282 TM-ABC transporter signature motif; other site 649831005283 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 649831005284 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 649831005285 Walker A/P-loop; other site 649831005286 ATP binding site [chemical binding]; other site 649831005287 Q-loop/lid; other site 649831005288 ABC transporter signature motif; other site 649831005289 Walker B; other site 649831005290 D-loop; other site 649831005291 H-loop/switch region; other site 649831005292 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 649831005293 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 649831005294 Walker A/P-loop; other site 649831005295 ATP binding site [chemical binding]; other site 649831005296 Q-loop/lid; other site 649831005297 ABC transporter signature motif; other site 649831005298 Walker B; other site 649831005299 D-loop; other site 649831005300 H-loop/switch region; other site 649831005301 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 649831005302 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 649831005303 substrate binding pocket [chemical binding]; other site 649831005304 membrane-bound complex binding site; other site 649831005305 hinge residues; other site 649831005306 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 649831005307 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649831005308 dimer interface [polypeptide binding]; other site 649831005309 conserved gate region; other site 649831005310 putative PBP binding loops; other site 649831005311 ABC-ATPase subunit interface; other site 649831005312 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 649831005313 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 649831005314 Walker A/P-loop; other site 649831005315 ATP binding site [chemical binding]; other site 649831005316 Q-loop/lid; other site 649831005317 ABC transporter signature motif; other site 649831005318 Walker B; other site 649831005319 D-loop; other site 649831005320 H-loop/switch region; other site 649831005321 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 649831005322 DNA polymerase I; Provisional; Region: PRK05755 649831005323 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 649831005324 active site 649831005325 metal binding site 1 [ion binding]; metal-binding site 649831005326 putative 5' ssDNA interaction site; other site 649831005327 metal binding site 3; metal-binding site 649831005328 metal binding site 2 [ion binding]; metal-binding site 649831005329 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 649831005330 putative DNA binding site [nucleotide binding]; other site 649831005331 putative metal binding site [ion binding]; other site 649831005332 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 649831005333 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 649831005334 active site 649831005335 DNA binding site [nucleotide binding] 649831005336 catalytic site [active] 649831005337 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 649831005338 dimerization interface [polypeptide binding]; other site 649831005339 putative DNA binding site [nucleotide binding]; other site 649831005340 putative Zn2+ binding site [ion binding]; other site 649831005341 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 649831005342 cleavage site 649831005343 active site 649831005344 substrate binding sites [chemical binding]; other site 649831005345 Protein of unknown function (DUF3140); Region: DUF3140; pfam11338 649831005346 Protein of unknown function (DUF2945); Region: DUF2945; pfam11160 649831005347 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649831005348 S-adenosylmethionine binding site [chemical binding]; other site 649831005349 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 649831005350 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 649831005351 RNA binding site [nucleotide binding]; other site 649831005352 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 649831005353 RNA binding site [nucleotide binding]; other site 649831005354 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 649831005355 RNA binding site [nucleotide binding]; other site 649831005356 S1 RNA binding domain; Region: S1; pfam00575 649831005357 RNA binding site [nucleotide binding]; other site 649831005358 dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333 649831005359 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 649831005360 CoA-binding site [chemical binding]; other site 649831005361 ATP-binding [chemical binding]; other site 649831005362 Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987 649831005363 excinuclease ABC subunit B; Provisional; Region: PRK05298 649831005364 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 649831005365 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 649831005366 nucleotide binding region [chemical binding]; other site 649831005367 ATP-binding site [chemical binding]; other site 649831005368 Ultra-violet resistance protein B; Region: UvrB; pfam12344 649831005369 UvrB/uvrC motif; Region: UVR; pfam02151 649831005370 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 649831005371 Coenzyme A binding pocket [chemical binding]; other site 649831005372 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 649831005373 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 649831005374 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 649831005375 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 649831005376 G1 box; other site 649831005377 putative GEF interaction site [polypeptide binding]; other site 649831005378 GTP/Mg2+ binding site [chemical binding]; other site 649831005379 Switch I region; other site 649831005380 G2 box; other site 649831005381 G3 box; other site 649831005382 Switch II region; other site 649831005383 G4 box; other site 649831005384 G5 box; other site 649831005385 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 649831005386 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 649831005387 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 649831005388 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 649831005389 N-acetyl-D-glucosamine binding site [chemical binding]; other site 649831005390 catalytic residue [active] 649831005391 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 649831005392 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 649831005393 23S rRNA interface [nucleotide binding]; other site 649831005394 L7/L12 interface [polypeptide binding]; other site 649831005395 putative thiostrepton binding site; other site 649831005396 L25 interface [polypeptide binding]; other site 649831005397 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 649831005398 Clp protease; Region: CLP_protease; pfam00574 649831005399 active site 649831005400 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 649831005401 mycothiol-dependent maleylpyruvate isomerase; Reviewed; Region: PRK09583 649831005402 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 649831005403 GTPase RsgA; Reviewed; Region: PRK01889 649831005404 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 649831005405 GTPase/Zn-binding domain interface [polypeptide binding]; other site 649831005406 GTP/Mg2+ binding site [chemical binding]; other site 649831005407 G4 box; other site 649831005408 G5 box; other site 649831005409 G1 box; other site 649831005410 Switch I region; other site 649831005411 G2 box; other site 649831005412 G3 box; other site 649831005413 Switch II region; other site 649831005414 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 649831005415 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 649831005416 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 649831005417 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 649831005418 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 649831005419 iron-sulfur cluster [ion binding]; other site 649831005420 [2Fe-2S] cluster binding site [ion binding]; other site 649831005421 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 649831005422 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 649831005423 GIY-YIG motif/motif A; other site 649831005424 active site 649831005425 catalytic site [active] 649831005426 putative DNA binding site [nucleotide binding]; other site 649831005427 metal binding site [ion binding]; metal-binding site 649831005428 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 649831005429 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 649831005430 helix-hairpin-helix signature motif; other site 649831005431 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 649831005432 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 649831005433 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 649831005434 phosphate binding site [ion binding]; other site 649831005435 putative substrate binding pocket [chemical binding]; other site 649831005436 dimer interface [polypeptide binding]; other site 649831005437 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 649831005438 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 649831005439 Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324 649831005440 short chain dehydrogenase; Provisional; Region: PRK12937 649831005441 NADP binding site [chemical binding]; other site 649831005442 substrate binding site [chemical binding]; other site 649831005443 active site 649831005444 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 649831005445 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 649831005446 dimerization interface [polypeptide binding]; other site 649831005447 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 649831005448 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 649831005449 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 649831005450 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 649831005451 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 649831005452 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831005453 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 649831005454 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 649831005455 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 649831005456 Phosphoglycerate kinase; Region: PGK; pfam00162 649831005457 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 649831005458 substrate binding site [chemical binding]; other site 649831005459 hinge regions; other site 649831005460 ADP binding site [chemical binding]; other site 649831005461 catalytic site [active] 649831005462 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 649831005463 triosephosphate isomerase; Provisional; Region: PRK14567 649831005464 substrate binding site [chemical binding]; other site 649831005465 dimer interface [polypeptide binding]; other site 649831005466 catalytic triad [active] 649831005467 Preprotein translocase SecG subunit; Region: SecG; cl09123 649831005468 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 649831005469 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 649831005470 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 649831005471 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 649831005472 DNA binding residues [nucleotide binding] 649831005473 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 649831005474 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 649831005475 hypothetical protein; Provisional; Region: PRK06847 649831005476 hypothetical protein; Provisional; Region: PRK07236 649831005477 Epoxide hydrolase N terminus; Region: EHN; pfam06441 649831005478 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 649831005479 CGNR zinc finger; Region: zf-CGNR; pfam11706 649831005480 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 649831005481 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 649831005482 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 649831005483 putative active site [active] 649831005484 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 649831005485 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 649831005486 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 649831005487 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 649831005488 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 649831005489 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 649831005490 putative active site [active] 649831005491 transaldolase; Provisional; Region: PRK03903 649831005492 catalytic residue [active] 649831005493 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 649831005494 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 649831005495 TPP-binding site [chemical binding]; other site 649831005496 dimer interface [polypeptide binding]; other site 649831005497 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 649831005498 PYR/PP interface [polypeptide binding]; other site 649831005499 dimer interface [polypeptide binding]; other site 649831005500 TPP binding site [chemical binding]; other site 649831005501 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 649831005502 UbiA prenyltransferase family; Region: UbiA; pfam01040 649831005503 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 649831005504 Predicted transcriptional regulator [Transcription]; Region: COG2345 649831005505 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 649831005506 putative DNA binding site [nucleotide binding]; other site 649831005507 putative Zn2+ binding site [ion binding]; other site 649831005508 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 649831005509 FeS assembly protein SufB; Region: sufB; TIGR01980 649831005510 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 649831005511 FeS assembly protein SufD; Region: sufD; TIGR01981 649831005512 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 649831005513 [2Fe-2S] cluster binding site [ion binding]; other site 649831005514 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 649831005515 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 649831005516 Walker A/P-loop; other site 649831005517 ATP binding site [chemical binding]; other site 649831005518 Q-loop/lid; other site 649831005519 ABC transporter signature motif; other site 649831005520 Walker B; other site 649831005521 D-loop; other site 649831005522 H-loop/switch region; other site 649831005523 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 649831005524 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 649831005525 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 649831005526 catalytic residue [active] 649831005527 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 649831005528 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 649831005529 trimerization site [polypeptide binding]; other site 649831005530 active site 649831005531 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 649831005532 hypothetical protein; Provisional; Region: PRK08262 649831005533 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 649831005534 metal binding site [ion binding]; metal-binding site 649831005535 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 649831005536 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 649831005537 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 649831005538 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 649831005539 active site 649831005540 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 649831005541 catalytic core [active] 649831005542 oxidoreductase; Provisional; Region: PRK06196 649831005543 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831005544 NAD(P) binding site [chemical binding]; other site 649831005545 active site 649831005546 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 649831005547 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831005548 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 649831005549 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 649831005550 DNA binding residues [nucleotide binding] 649831005551 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 649831005552 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 649831005553 Sulfate transporter family; Region: Sulfate_transp; pfam00916 649831005554 Sulfate transporter family; Region: Sulfate_transp; pfam00916 649831005555 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 649831005556 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 649831005557 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 649831005558 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 649831005559 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649831005560 Walker A/P-loop; other site 649831005561 ATP binding site [chemical binding]; other site 649831005562 Q-loop/lid; other site 649831005563 ABC transporter signature motif; other site 649831005564 Walker B; other site 649831005565 D-loop; other site 649831005566 H-loop/switch region; other site 649831005567 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 649831005568 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 649831005569 substrate binding site [chemical binding]; other site 649831005570 oxyanion hole (OAH) forming residues; other site 649831005571 trimer interface [polypeptide binding]; other site 649831005572 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 649831005573 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 649831005574 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649831005575 Walker A/P-loop; other site 649831005576 ATP binding site [chemical binding]; other site 649831005577 Q-loop/lid; other site 649831005578 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 649831005579 ABC transporter signature motif; other site 649831005580 Walker B; other site 649831005581 D-loop; other site 649831005582 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 649831005583 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 649831005584 Domain of unknown function (DUF385); Region: DUF385; pfam04075 649831005585 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 649831005586 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831005587 C factor cell-cell signaling protein; Provisional; Region: PRK09009 649831005588 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831005589 NAD(P) binding site [chemical binding]; other site 649831005590 active site 649831005591 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 649831005592 active site 649831005593 SUMO-1 interface [polypeptide binding]; other site 649831005594 hypothetical protein; Provisional; Region: PRK05409 649831005595 TIGR04222 domain; Region: near_uncomplex 649831005596 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 649831005597 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831005598 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 649831005599 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 649831005600 motif II; other site 649831005601 RIO kinase family, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside...; Region: RIO; cl17248 649831005602 ATP binding site [chemical binding]; other site 649831005603 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 649831005604 TIGR03086 family protein; Region: TIGR03086 649831005605 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 649831005606 Septum formation; Region: Septum_form; pfam13845 649831005607 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 649831005608 MarR family; Region: MarR_2; pfam12802 649831005609 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 649831005610 classical (c) SDRs; Region: SDR_c; cd05233 649831005611 NAD(P) binding site [chemical binding]; other site 649831005612 active site 649831005613 aconitate hydratase; Validated; Region: PRK09277 649831005614 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 649831005615 substrate binding site [chemical binding]; other site 649831005616 ligand binding site [chemical binding]; other site 649831005617 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 649831005618 substrate binding site [chemical binding]; other site 649831005619 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 649831005620 carbohydrate binding site [chemical binding]; other site 649831005621 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 649831005622 carbohydrate binding site [chemical binding]; other site 649831005623 alpha-1,6-glucosidases, pullulanase-type; Region: pullul_strch; TIGR02103 649831005624 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 649831005625 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 649831005626 Ca binding site [ion binding]; other site 649831005627 active site 649831005628 catalytic site [active] 649831005629 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 649831005630 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 649831005631 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 649831005632 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 649831005633 Protein of unknown function (DUF419); Region: DUF419; cl15265 649831005634 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 649831005635 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649831005636 S-adenosylmethionine binding site [chemical binding]; other site 649831005637 proline aminopeptidase P II; Provisional; Region: PRK10879 649831005638 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 649831005639 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 649831005640 active site 649831005641 Copper/zinc superoxide dismutase (SODC); Region: Sod_Cu; pfam00080 649831005642 P-class dimer interface [polypeptide binding]; other site 649831005643 active site 649831005644 Cu2+ binding site [ion binding]; other site 649831005645 Zn2+ binding site [ion binding]; other site 649831005646 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 649831005647 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 649831005648 putative substrate binding site [chemical binding]; other site 649831005649 putative ATP binding site [chemical binding]; other site 649831005650 Predicted thioesterase [General function prediction only]; Region: COG5496 649831005651 hypothetical protein; Provisional; Region: PRK07236 649831005652 FAD binding domain; Region: FAD_binding_3; pfam01494 649831005653 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831005654 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 649831005655 Bacterial PH domain; Region: DUF304; pfam03703 649831005656 Bacterial PH domain; Region: DUF304; pfam03703 649831005657 Bacterial PH domain; Region: DUF304; pfam03703 649831005658 Uncharacterized conserved protein [Function unknown]; Region: COG3402 649831005659 MoxR-like ATPases [General function prediction only]; Region: COG0714 649831005660 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 649831005661 Walker A motif; other site 649831005662 ATP binding site [chemical binding]; other site 649831005663 Walker B motif; other site 649831005664 arginine finger; other site 649831005665 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 649831005666 von Willebrand factor type A domain; Region: VWA_2; pfam13519 649831005667 metal ion-dependent adhesion site (MIDAS); other site 649831005668 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 649831005669 Pollen allergen; Region: Pollen_allerg_1; cl08320 649831005670 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 649831005671 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 649831005672 NAD(P) binding site [chemical binding]; other site 649831005673 homotetramer interface [polypeptide binding]; other site 649831005674 homodimer interface [polypeptide binding]; other site 649831005675 active site 649831005676 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 649831005677 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 649831005678 NAD binding site [chemical binding]; other site 649831005679 homotetramer interface [polypeptide binding]; other site 649831005680 homodimer interface [polypeptide binding]; other site 649831005681 substrate binding site [chemical binding]; other site 649831005682 active site 649831005683 ferrochelatase; Reviewed; Region: hemH; PRK00035 649831005684 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 649831005685 C-terminal domain interface [polypeptide binding]; other site 649831005686 active site 649831005687 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 649831005688 active site 649831005689 N-terminal domain interface [polypeptide binding]; other site 649831005690 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 649831005691 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 649831005692 active site 649831005693 motif I; other site 649831005694 motif II; other site 649831005695 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 649831005696 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831005697 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 649831005698 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 649831005699 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 649831005700 nudix motif; other site 649831005701 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 649831005702 nudix motif; other site 649831005703 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 649831005704 RibD C-terminal domain; Region: RibD_C; cl17279 649831005705 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 649831005706 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 649831005707 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 649831005708 Beta-lactamase; Region: Beta-lactamase; pfam00144 649831005709 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 649831005710 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 649831005711 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 649831005712 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831005713 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 649831005714 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 649831005715 pyridoxal 5'-phosphate binding site [chemical binding]; other site 649831005716 homodimer interface [polypeptide binding]; other site 649831005717 catalytic residue [active] 649831005718 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 649831005719 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 649831005720 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 649831005721 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 649831005722 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 649831005723 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 649831005724 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 649831005725 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831005726 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 649831005727 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831005728 NAD(P) binding site [chemical binding]; other site 649831005729 active site 649831005730 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 649831005731 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 649831005732 Glutamate binding site [chemical binding]; other site 649831005733 NAD binding site [chemical binding]; other site 649831005734 catalytic residues [active] 649831005735 Proline dehydrogenase; Region: Pro_dh; cl03282 649831005736 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 649831005737 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 649831005738 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 649831005739 FAD binding pocket [chemical binding]; other site 649831005740 conserved FAD binding motif [chemical binding]; other site 649831005741 phosphate binding motif [ion binding]; other site 649831005742 beta-alpha-beta structure motif; other site 649831005743 NAD binding pocket [chemical binding]; other site 649831005744 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 649831005745 active site 649831005746 catalytic triad [active] 649831005747 oxyanion hole [active] 649831005748 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK04690 649831005749 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 649831005750 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 649831005751 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 649831005752 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 649831005753 putative active site [active] 649831005754 carbohydrate ABC transporter, N-acetylglucosamine/diacetylchitobiose-binding protein; Region: chitin_NgcE; TIGR03851 649831005755 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 649831005756 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 649831005757 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649831005758 putative PBP binding loops; other site 649831005759 dimer interface [polypeptide binding]; other site 649831005760 ABC-ATPase subunit interface; other site 649831005761 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 649831005762 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649831005763 dimer interface [polypeptide binding]; other site 649831005764 conserved gate region; other site 649831005765 putative PBP binding loops; other site 649831005766 ABC-ATPase subunit interface; other site 649831005767 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 649831005768 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 649831005769 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 649831005770 DNA binding residues [nucleotide binding] 649831005771 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 649831005772 bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975 649831005773 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cd06444 649831005774 active site 649831005775 DNA binding site [nucleotide binding] 649831005776 catalytic site [active] 649831005777 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 649831005778 MarR family; Region: MarR; pfam01047 649831005779 FAD binding domain; Region: FAD_binding_3; pfam01494 649831005780 hypothetical protein; Provisional; Region: PRK07236 649831005781 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 649831005782 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 649831005783 Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439 649831005784 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 649831005785 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 649831005786 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 649831005787 active site 649831005788 metal binding site [ion binding]; metal-binding site 649831005789 hexamer interface [polypeptide binding]; other site 649831005790 Transcriptional regulators [Transcription]; Region: MarR; COG1846 649831005791 MarR family; Region: MarR; pfam01047 649831005792 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 649831005793 nudix motif; other site 649831005794 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649831005795 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831005796 active site 649831005797 phosphorylation site [posttranslational modification] 649831005798 intermolecular recognition site; other site 649831005799 dimerization interface [polypeptide binding]; other site 649831005800 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649831005801 DNA binding residues [nucleotide binding] 649831005802 dimerization interface [polypeptide binding]; other site 649831005803 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 649831005804 Histidine kinase; Region: HisKA_3; pfam07730 649831005805 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831005806 ATP binding site [chemical binding]; other site 649831005807 Mg2+ binding site [ion binding]; other site 649831005808 G-X-G motif; other site 649831005809 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 649831005810 2TM domain; Region: 2TM; pfam13239 649831005811 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 649831005812 short chain dehydrogenase; Provisional; Region: PRK06180 649831005813 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831005814 NAD(P) binding site [chemical binding]; other site 649831005815 active site 649831005816 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 649831005817 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831005818 Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200 649831005819 seryl-tRNA synthetase; Provisional; Region: PRK05431 649831005820 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 649831005821 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 649831005822 dimer interface [polypeptide binding]; other site 649831005823 active site 649831005824 motif 1; other site 649831005825 motif 2; other site 649831005826 motif 3; other site 649831005827 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 649831005828 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 649831005829 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 649831005830 NAD(P) binding site [chemical binding]; other site 649831005831 catalytic residues [active] 649831005832 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 649831005833 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 649831005834 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 649831005835 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 649831005836 inhibitor-cofactor binding pocket; inhibition site 649831005837 pyridoxal 5'-phosphate binding site [chemical binding]; other site 649831005838 catalytic residue [active] 649831005839 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 649831005840 hydrophobic ligand binding site; other site 649831005841 Domain of unknown function (DUF4260); Region: DUF4260; pfam14079 649831005842 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 649831005843 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 649831005844 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 649831005845 dimer interface [polypeptide binding]; other site 649831005846 active site 649831005847 CoA binding pocket [chemical binding]; other site 649831005848 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 649831005849 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 649831005850 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 649831005851 dimer interface [polypeptide binding]; other site 649831005852 active site 649831005853 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 649831005854 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 649831005855 active site 2 [active] 649831005856 active site 1 [active] 649831005857 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 649831005858 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831005859 NAD(P) binding site [chemical binding]; other site 649831005860 active site 649831005861 SnoaL-like domain; Region: SnoaL_2; pfam12680 649831005862 benzoate transport; Region: 2A0115; TIGR00895 649831005863 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831005864 putative substrate translocation pore; other site 649831005865 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831005866 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 649831005867 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 649831005868 Cytochrome P450; Region: p450; cl12078 649831005869 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 649831005870 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831005871 Major Facilitator Superfamily; Region: MFS_1; pfam07690 649831005872 putative substrate translocation pore; other site 649831005873 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831005874 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 649831005875 DNA binding site [nucleotide binding] 649831005876 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 649831005877 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 649831005878 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 649831005879 Fatty acid desaturase; Region: FA_desaturase; pfam00487 649831005880 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 649831005881 putative di-iron ligands [ion binding]; other site 649831005882 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831005883 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 649831005884 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831005885 active site 649831005886 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 649831005887 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 649831005888 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 649831005889 KR domain; Region: KR; pfam08659 649831005890 putative NADP binding site [chemical binding]; other site 649831005891 active site 649831005892 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831005893 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 649831005894 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 649831005895 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 649831005896 acyl-activating enzyme (AAE) consensus motif; other site 649831005897 acyl-activating enzyme (AAE) consensus motif; other site 649831005898 putative AMP binding site [chemical binding]; other site 649831005899 putative active site [active] 649831005900 putative CoA binding site [chemical binding]; other site 649831005901 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 649831005902 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 649831005903 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 649831005904 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 649831005905 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 649831005906 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 649831005907 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 649831005908 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 649831005909 DNA binding residues [nucleotide binding] 649831005910 SnoaL-like domain; Region: SnoaL_2; pfam12680 649831005911 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831005912 NADH(P)-binding; Region: NAD_binding_10; pfam13460 649831005913 NAD(P) binding site [chemical binding]; other site 649831005914 active site 649831005915 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 649831005916 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 649831005917 MarR family; Region: MarR_2; pfam12802 649831005918 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 649831005919 MMPL family; Region: MMPL; pfam03176 649831005920 Amidohydrolase; Region: Amidohydro_2; pfam04909 649831005921 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 649831005922 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831005923 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 649831005924 Predicted transcriptional regulators [Transcription]; Region: COG1510 649831005925 MarR family; Region: MarR_2; cl17246 649831005926 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 649831005927 nudix motif; other site 649831005928 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 649831005929 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 649831005930 catalytic residues [active] 649831005931 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 649831005932 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 649831005933 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649831005934 dimer interface [polypeptide binding]; other site 649831005935 conserved gate region; other site 649831005936 putative PBP binding loops; other site 649831005937 ABC-ATPase subunit interface; other site 649831005938 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 649831005939 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649831005940 dimer interface [polypeptide binding]; other site 649831005941 conserved gate region; other site 649831005942 putative PBP binding loops; other site 649831005943 ABC-ATPase subunit interface; other site 649831005944 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 649831005945 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 649831005946 Walker A/P-loop; other site 649831005947 ATP binding site [chemical binding]; other site 649831005948 Q-loop/lid; other site 649831005949 ABC transporter signature motif; other site 649831005950 Walker B; other site 649831005951 D-loop; other site 649831005952 H-loop/switch region; other site 649831005953 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 649831005954 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 649831005955 active site 649831005956 catalytic tetrad [active] 649831005957 Transcriptional regulators [Transcription]; Region: PurR; COG1609 649831005958 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 649831005959 DNA binding site [nucleotide binding] 649831005960 domain linker motif; other site 649831005961 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 649831005962 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 649831005963 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 649831005964 putative active site [active] 649831005965 putative NTP binding site [chemical binding]; other site 649831005966 putative nucleic acid binding site [nucleotide binding]; other site 649831005967 radical SAM/SPASM domain, FxsB family; Region: SAM_SPASM_FxsB; TIGR04269 649831005968 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 649831005969 FeS/SAM binding site; other site 649831005970 chorismate binding enzyme; Region: Chorismate_bind; cl10555 649831005971 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 649831005972 Glutamine amidotransferase class-I; Region: GATase; pfam00117 649831005973 glutamine binding [chemical binding]; other site 649831005974 catalytic triad [active] 649831005975 Response regulator receiver domain; Region: Response_reg; pfam00072 649831005976 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831005977 active site 649831005978 phosphorylation site [posttranslational modification] 649831005979 intermolecular recognition site; other site 649831005980 dimerization interface [polypeptide binding]; other site 649831005981 CHASE3 domain; Region: CHASE3; cl05000 649831005982 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 649831005983 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 649831005984 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 649831005985 dimer interface [polypeptide binding]; other site 649831005986 phosphorylation site [posttranslational modification] 649831005987 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831005988 ATP binding site [chemical binding]; other site 649831005989 Mg2+ binding site [ion binding]; other site 649831005990 G-X-G motif; other site 649831005991 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 649831005992 hydrophobic ligand binding site; other site 649831005993 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 649831005994 active site 649831005995 dimer interface [polypeptide binding]; other site 649831005996 motif 1; other site 649831005997 motif 2; other site 649831005998 motif 3; other site 649831005999 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 649831006000 anticodon binding site; other site 649831006001 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 649831006002 phosphate binding site [ion binding]; other site 649831006003 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 649831006004 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 649831006005 DNA binding residues [nucleotide binding] 649831006006 putative dimer interface [polypeptide binding]; other site 649831006007 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 649831006008 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 649831006009 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 649831006010 Coenzyme A binding pocket [chemical binding]; other site 649831006011 aminotransferase AlaT; Validated; Region: PRK09265 649831006012 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 649831006013 pyridoxal 5'-phosphate binding site [chemical binding]; other site 649831006014 homodimer interface [polypeptide binding]; other site 649831006015 catalytic residue [active] 649831006016 Transcriptional regulators [Transcription]; Region: MarR; COG1846 649831006017 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 649831006018 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 649831006019 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 649831006020 dimer interface [polypeptide binding]; other site 649831006021 phosphorylation site [posttranslational modification] 649831006022 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831006023 ATP binding site [chemical binding]; other site 649831006024 Mg2+ binding site [ion binding]; other site 649831006025 G-X-G motif; other site 649831006026 Response regulator receiver domain; Region: Response_reg; pfam00072 649831006027 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831006028 active site 649831006029 phosphorylation site [posttranslational modification] 649831006030 intermolecular recognition site; other site 649831006031 dimerization interface [polypeptide binding]; other site 649831006032 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 649831006033 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 649831006034 DXD motif; other site 649831006035 Protein of unknown function (DUF1405); Region: DUF1405; cl01798 649831006036 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 649831006037 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 649831006038 endonuclease III; Region: ENDO3c; smart00478 649831006039 minor groove reading motif; other site 649831006040 helix-hairpin-helix signature motif; other site 649831006041 substrate binding pocket [chemical binding]; other site 649831006042 active site 649831006043 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 649831006044 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 649831006045 active site 649831006046 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 649831006047 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 649831006048 active site 649831006049 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831006050 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 649831006051 hydrophobic ligand binding site; other site 649831006052 Predicted transcriptional regulators [Transcription]; Region: COG1733 649831006053 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 649831006054 EamA-like transporter family; Region: EamA; pfam00892 649831006055 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 649831006056 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 649831006057 putative DNA binding site [nucleotide binding]; other site 649831006058 putative Zn2+ binding site [ion binding]; other site 649831006059 AsnC family; Region: AsnC_trans_reg; pfam01037 649831006060 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 649831006061 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 649831006062 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 649831006063 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831006064 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 649831006065 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 649831006066 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 649831006067 Protein of unknown function DUF58; Region: DUF58; pfam01882 649831006068 MoxR-like ATPases [General function prediction only]; Region: COG0714 649831006069 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 649831006070 Walker B motif; other site 649831006071 arginine finger; other site 649831006072 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 649831006073 Interdomain contacts; other site 649831006074 Cytokine receptor motif; other site 649831006075 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 649831006076 Interdomain contacts; other site 649831006077 Cytokine receptor motif; other site 649831006078 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 649831006079 Interdomain contacts; other site 649831006080 Cytokine receptor motif; other site 649831006081 Tetratricopeptide repeat; Region: TPR_12; pfam13424 649831006082 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 649831006083 Predicted transcriptional regulators [Transcription]; Region: COG1695 649831006084 Transcriptional regulator PadR-like family; Region: PadR; cl17335 649831006085 hypothetical protein; Provisional; Region: PRK08244 649831006086 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 649831006087 Staphylococcal nuclease homologues; Region: SNc; smart00318 649831006088 Lamin Tail Domain; Region: LTD; pfam00932 649831006089 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 649831006090 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 649831006091 putative NAD(P) binding site [chemical binding]; other site 649831006092 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 649831006093 MarR family; Region: MarR; pfam01047 649831006094 short chain dehydrogenase; Provisional; Region: PRK06523 649831006095 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831006096 NAD(P) binding site [chemical binding]; other site 649831006097 active site 649831006098 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 649831006099 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831006100 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 649831006101 SEC-C motif; Region: SEC-C; pfam02810 649831006102 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 649831006103 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831006104 ATP binding site [chemical binding]; other site 649831006105 Mg2+ binding site [ion binding]; other site 649831006106 G-X-G motif; other site 649831006107 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 649831006108 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 649831006109 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 649831006110 dimanganese center [ion binding]; other site 649831006111 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 649831006112 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 649831006113 putative DNA binding site [nucleotide binding]; other site 649831006114 putative homodimer interface [polypeptide binding]; other site 649831006115 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 649831006116 putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055 649831006117 FeS/SAM binding site; other site 649831006118 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 649831006119 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831006120 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 649831006121 Cytochrome P450; Region: p450; cl12078 649831006122 NAD-dependent deacetylase; Provisional; Region: PRK00481 649831006123 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 649831006124 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 649831006125 dimerization interface [polypeptide binding]; other site 649831006126 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 649831006127 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 649831006128 dimer interface [polypeptide binding]; other site 649831006129 putative CheW interface [polypeptide binding]; other site 649831006130 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 649831006131 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831006132 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 649831006133 putative substrate translocation pore; other site 649831006134 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 649831006135 DNA binding site [nucleotide binding] 649831006136 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 649831006137 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 649831006138 AAA ATPase domain; Region: AAA_16; pfam13191 649831006139 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649831006140 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649831006141 DNA binding residues [nucleotide binding] 649831006142 dimerization interface [polypeptide binding]; other site 649831006143 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 649831006144 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 649831006145 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 649831006146 Cytochrome P450; Region: p450; cl12078 649831006147 hypothetical protein; Provisional; Region: PRK08244 649831006148 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 649831006149 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 649831006150 hypothetical protein; Provisional; Region: PRK08244 649831006151 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 649831006152 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831006153 short chain dehydrogenase; Provisional; Region: PRK07041 649831006154 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831006155 NAD(P) binding site [chemical binding]; other site 649831006156 active site 649831006157 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 649831006158 Cytochrome P450; Region: p450; cl12078 649831006159 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 649831006160 NmrA-like family; Region: NmrA; pfam05368 649831006161 NADP binding site [chemical binding]; other site 649831006162 active site 649831006163 regulatory binding site [polypeptide binding]; other site 649831006164 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 649831006165 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831006166 putative substrate translocation pore; other site 649831006167 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831006168 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 649831006169 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831006170 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 649831006171 Erythronolide synthase docking; Region: Docking; pfam08990 649831006172 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831006173 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 649831006174 active site 649831006175 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 649831006176 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 649831006177 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831006178 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 649831006179 KR domain; Region: KR; pfam08659 649831006180 active site 649831006181 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831006182 Erythronolide synthase docking; Region: Docking; pfam08990 649831006183 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 649831006184 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831006185 active site 649831006186 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 649831006187 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 649831006188 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831006189 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831006190 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 649831006191 active site 649831006192 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 649831006193 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 649831006194 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 649831006195 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 649831006196 putative NADP binding site [chemical binding]; other site 649831006197 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 649831006198 active site 649831006199 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831006200 Erythronolide synthase docking; Region: Docking; pfam08990 649831006201 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 649831006202 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831006203 active site 649831006204 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 649831006205 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 649831006206 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831006207 NAD(P) binding site [chemical binding]; other site 649831006208 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 649831006209 active site 649831006210 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831006211 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831006212 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 649831006213 active site 649831006214 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 649831006215 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 649831006216 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 649831006217 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 649831006218 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 649831006219 Enoylreductase; Region: PKS_ER; smart00829 649831006220 NAD(P) binding site [chemical binding]; other site 649831006221 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 649831006222 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 649831006223 putative NADP binding site [chemical binding]; other site 649831006224 active site 649831006225 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831006226 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831006227 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 649831006228 active site 649831006229 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 649831006230 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 649831006231 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831006232 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831006233 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 649831006234 active site 649831006235 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 649831006236 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 649831006237 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 649831006238 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 649831006239 putative NADP binding site [chemical binding]; other site 649831006240 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 649831006241 active site 649831006242 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831006243 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 649831006244 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831006245 active site 649831006246 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 649831006247 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 649831006248 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 649831006249 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831006250 NAD(P) binding site [chemical binding]; other site 649831006251 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 649831006252 active site 649831006253 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831006254 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 649831006255 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831006256 active site 649831006257 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 649831006258 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 649831006259 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831006260 NAD(P) binding site [chemical binding]; other site 649831006261 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 649831006262 active site 649831006263 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831006264 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 649831006265 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 649831006266 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 649831006267 Predicted enzyme involved in methoxymalonyl-ACP biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FkbH; COG3882 649831006268 Acid Phosphatase; Region: Acid_PPase; cl17256 649831006269 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 649831006270 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 649831006271 active site 649831006272 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal; Region: ACP_syn_III_C; cl17241 649831006273 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 649831006274 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 649831006275 heterodimer interface [polypeptide binding]; other site 649831006276 substrate interaction site [chemical binding]; other site 649831006277 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 649831006278 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 649831006279 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 649831006280 B12 binding site [chemical binding]; other site 649831006281 cobalt ligand [ion binding]; other site 649831006282 membrane ATPase/protein kinase; Provisional; Region: PRK09435 649831006283 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 649831006284 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 649831006285 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 649831006286 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 649831006287 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 649831006288 active site 649831006289 PRC-barrel domain; Region: PRC; pfam05239 649831006290 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 649831006291 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 649831006292 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 649831006293 Domain of unknown function (DUF1768); Region: DUF1768; cl01271 649831006294 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 649831006295 Zn binding site [ion binding]; other site 649831006296 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 649831006297 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cd00596 649831006298 active site 649831006299 Zn binding site [ion binding]; other site 649831006300 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 649831006301 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 649831006302 ParB-like nuclease domain; Region: ParB; smart00470 649831006303 O-methyltransferase; Region: Methyltransf_2; pfam00891 649831006304 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 649831006305 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831006306 active site 649831006307 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 649831006308 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 649831006309 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831006310 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 649831006311 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831006312 active site 649831006313 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 649831006314 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 649831006315 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 649831006316 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 649831006317 putative NADP binding site [chemical binding]; other site 649831006318 active site 649831006319 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831006320 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 649831006321 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831006322 active site 649831006323 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 649831006324 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 649831006325 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 649831006326 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 649831006327 putative NADP binding site [chemical binding]; other site 649831006328 active site 649831006329 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831006330 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 649831006331 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831006332 active site 649831006333 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 649831006334 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 649831006335 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 649831006336 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 649831006337 putative NADP binding site [chemical binding]; other site 649831006338 active site 649831006339 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831006340 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831006341 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 649831006342 active site 649831006343 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 649831006344 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 649831006345 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 649831006346 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 649831006347 putative NADP binding site [chemical binding]; other site 649831006348 active site 649831006349 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831006350 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 649831006351 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831006352 active site 649831006353 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 649831006354 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 649831006355 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 649831006356 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 649831006357 putative NADP binding site [chemical binding]; other site 649831006358 active site 649831006359 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831006360 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 649831006361 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 649831006362 Erythronolide synthase docking; Region: Docking; pfam08990 649831006363 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 649831006364 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831006365 active site 649831006366 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 649831006367 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 649831006368 KR domain; Region: KR; pfam08659 649831006369 NADP binding site [chemical binding]; other site 649831006370 active site 649831006371 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831006372 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831006373 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 649831006374 active site 649831006375 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 649831006376 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 649831006377 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 649831006378 NADP binding site [chemical binding]; other site 649831006379 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 649831006380 active site 649831006381 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831006382 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831006383 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 649831006384 active site 649831006385 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 649831006386 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 649831006387 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 649831006388 NADP binding site [chemical binding]; other site 649831006389 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 649831006390 active site 649831006391 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831006392 Erythronolide synthase docking; Region: Docking; pfam08990 649831006393 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831006394 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 649831006395 active site 649831006396 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 649831006397 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 649831006398 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 649831006399 NADP binding site [chemical binding]; other site 649831006400 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 649831006401 active site 649831006402 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831006403 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 649831006404 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831006405 active site 649831006406 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 649831006407 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 649831006408 NADP binding site [chemical binding]; other site 649831006409 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 649831006410 active site 649831006411 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831006412 Erythronolide synthase docking; Region: Docking; pfam08990 649831006413 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831006414 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 649831006415 active site 649831006416 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 649831006417 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 649831006418 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 649831006419 NADP binding site [chemical binding]; other site 649831006420 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 649831006421 active site 649831006422 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831006423 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831006424 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 649831006425 active site 649831006426 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 649831006427 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 649831006428 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 649831006429 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 649831006430 NADP binding site [chemical binding]; other site 649831006431 active site 649831006432 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831006433 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831006434 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 649831006435 active site 649831006436 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 649831006437 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 649831006438 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831006439 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 649831006440 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 649831006441 NADP binding site [chemical binding]; other site 649831006442 active site 649831006443 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831006444 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831006445 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 649831006446 active site 649831006447 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 649831006448 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 649831006449 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 649831006450 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 649831006451 NADP binding site [chemical binding]; other site 649831006452 active site 649831006453 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831006454 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831006455 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 649831006456 active site 649831006457 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 649831006458 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 649831006459 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831006460 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 649831006461 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 649831006462 NADP binding site [chemical binding]; other site 649831006463 active site 649831006464 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831006465 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831006466 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 649831006467 active site 649831006468 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 649831006469 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 649831006470 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 649831006471 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 649831006472 NADP binding site [chemical binding]; other site 649831006473 active site 649831006474 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831006475 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831006476 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 649831006477 active site 649831006478 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 649831006479 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 649831006480 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 649831006481 NADP binding site [chemical binding]; other site 649831006482 active site 649831006483 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831006484 Erythronolide synthase docking; Region: Docking; pfam08990 649831006485 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 649831006486 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831006487 active site 649831006488 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 649831006489 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 649831006490 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 649831006491 NADP binding site [chemical binding]; other site 649831006492 active site 649831006493 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831006494 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 649831006495 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831006496 active site 649831006497 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 649831006498 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 649831006499 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 649831006500 putative NADP binding site [chemical binding]; other site 649831006501 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 649831006502 active site 649831006503 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831006504 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831006505 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 649831006506 active site 649831006507 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 649831006508 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 649831006509 NADP binding site [chemical binding]; other site 649831006510 KR domain; Region: KR; pfam08659 649831006511 active site 649831006512 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831006513 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831006514 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 649831006515 active site 649831006516 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 649831006517 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 649831006518 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 649831006519 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831006520 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 649831006521 Enoylreductase; Region: PKS_ER; smart00829 649831006522 NAD(P) binding site [chemical binding]; other site 649831006523 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 649831006524 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 649831006525 putative NADP binding site [chemical binding]; other site 649831006526 active site 649831006527 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831006528 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 649831006529 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831006530 active site 649831006531 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 649831006532 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 649831006533 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831006534 Enoylreductase; Region: PKS_ER; smart00829 649831006535 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 649831006536 NAD(P) binding site [chemical binding]; other site 649831006537 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 649831006538 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 649831006539 putative NADP binding site [chemical binding]; other site 649831006540 active site 649831006541 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831006542 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 649831006543 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831006544 active site 649831006545 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 649831006546 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 649831006547 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 649831006548 putative NADP binding site [chemical binding]; other site 649831006549 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 649831006550 active site 649831006551 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831006552 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831006553 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 649831006554 active site 649831006555 Acyl transferase domain; Region: Acyl_transf_1; cl08282 649831006556 Acyl transferase domain; Region: Acyl_transf_1; cl08282 649831006557 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831006558 Condensation domain; Region: Condensation; pfam00668 649831006559 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 649831006560 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 649831006561 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 649831006562 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 649831006563 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 649831006564 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 649831006565 acyl carrier protein; Provisional; Region: PRK07081 649831006566 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 649831006567 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 649831006568 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 649831006569 active site 649831006570 FkbH-like domain; Region: FkbH; TIGR01686 649831006571 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 649831006572 active site 649831006573 motif I; other site 649831006574 motif II; other site 649831006575 Erythronolide synthase docking; Region: Docking; pfam08990 649831006576 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831006577 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 649831006578 active site 649831006579 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 649831006580 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 649831006581 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 649831006582 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 649831006583 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 649831006584 putative NADP binding site [chemical binding]; other site 649831006585 active site 649831006586 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831006587 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 649831006588 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 649831006589 acyl-activating enzyme (AAE) consensus motif; other site 649831006590 AMP binding site [chemical binding]; other site 649831006591 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 649831006592 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 649831006593 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 649831006594 Walker A/P-loop; other site 649831006595 ATP binding site [chemical binding]; other site 649831006596 Q-loop/lid; other site 649831006597 ABC transporter signature motif; other site 649831006598 Walker B; other site 649831006599 D-loop; other site 649831006600 H-loop/switch region; other site 649831006601 MMPL family; Region: MMPL; pfam03176 649831006602 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649831006603 ParB-like nuclease domain; Region: ParBc; pfam02195 649831006604 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649831006605 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831006606 active site 649831006607 phosphorylation site [posttranslational modification] 649831006608 intermolecular recognition site; other site 649831006609 dimerization interface [polypeptide binding]; other site 649831006610 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649831006611 DNA binding residues [nucleotide binding] 649831006612 Histidine kinase; Region: HisKA_3; pfam07730 649831006613 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831006614 ATP binding site [chemical binding]; other site 649831006615 Mg2+ binding site [ion binding]; other site 649831006616 G-X-G motif; other site 649831006617 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 649831006618 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 649831006619 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649831006620 Walker A/P-loop; other site 649831006621 ATP binding site [chemical binding]; other site 649831006622 Q-loop/lid; other site 649831006623 ABC transporter signature motif; other site 649831006624 Walker B; other site 649831006625 D-loop; other site 649831006626 H-loop/switch region; other site 649831006627 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 649831006628 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 649831006629 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 649831006630 Walker A/P-loop; other site 649831006631 ATP binding site [chemical binding]; other site 649831006632 Q-loop/lid; other site 649831006633 ABC transporter signature motif; other site 649831006634 Walker B; other site 649831006635 D-loop; other site 649831006636 H-loop/switch region; other site 649831006637 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 649831006638 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831006639 short chain dehydrogenase; Provisional; Region: PRK06500 649831006640 classical (c) SDRs; Region: SDR_c; cd05233 649831006641 NAD(P) binding site [chemical binding]; other site 649831006642 active site 649831006643 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 649831006644 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 649831006645 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 649831006646 dinuclear metal binding motif [ion binding]; other site 649831006647 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 649831006648 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 649831006649 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 649831006650 Beta-lactamase; Region: Beta-lactamase; pfam00144 649831006651 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 649831006652 putative hydrophobic ligand binding site [chemical binding]; other site 649831006653 protein interface [polypeptide binding]; other site 649831006654 gate; other site 649831006655 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 649831006656 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 649831006657 dimer interface [polypeptide binding]; other site 649831006658 phosphorylation site [posttranslational modification] 649831006659 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831006660 ATP binding site [chemical binding]; other site 649831006661 Mg2+ binding site [ion binding]; other site 649831006662 G-X-G motif; other site 649831006663 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831006664 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 649831006665 active site 649831006666 phosphorylation site [posttranslational modification] 649831006667 intermolecular recognition site; other site 649831006668 dimerization interface [polypeptide binding]; other site 649831006669 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 649831006670 DNA binding site [nucleotide binding] 649831006671 Helix-turn-helix domain; Region: HTH_31; pfam13560 649831006672 MgtE intracellular N domain; Region: MgtE_N; cl15244 649831006673 Surface antigen [General function prediction only]; Region: COG3942 649831006674 CHAP domain; Region: CHAP; cl17642 649831006675 Transcriptional regulator [Transcription]; Region: LysR; COG0583 649831006676 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 649831006677 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 649831006678 dimerization interface [polypeptide binding]; other site 649831006679 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 649831006680 classical (c) SDRs; Region: SDR_c; cd05233 649831006681 NAD(P) binding site [chemical binding]; other site 649831006682 active site 649831006683 short chain dehydrogenase; Validated; Region: PRK08264 649831006684 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831006685 NAD(P) binding site [chemical binding]; other site 649831006686 active site 649831006687 Cupin; Region: Cupin_6; pfam12852 649831006688 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 649831006689 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 649831006690 pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14853 649831006691 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 649831006692 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831006693 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649831006694 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 649831006695 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 649831006696 putative sugar binding sites [chemical binding]; other site 649831006697 Q-X-W motif; other site 649831006698 PQQ-like domain; Region: PQQ_2; pfam13360 649831006699 MASE1; Region: MASE1; cl17823 649831006700 GAF domain; Region: GAF_3; pfam13492 649831006701 GAF domain; Region: GAF_2; pfam13185 649831006702 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 649831006703 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 649831006704 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 649831006705 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 649831006706 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831006707 Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042 649831006708 Predicted amidohydrolase [General function prediction only]; Region: COG0388 649831006709 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 649831006710 active site 649831006711 catalytic triad [active] 649831006712 dimer interface [polypeptide binding]; other site 649831006713 Domain of unknown function (DUF1768); Region: DUF1768; cl01271 649831006714 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 649831006715 active site 649831006716 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 649831006717 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 649831006718 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831006719 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 649831006720 NAD(P) binding site [chemical binding]; other site 649831006721 active site 649831006722 Cupin; Region: Cupin_6; pfam12852 649831006723 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 649831006724 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 649831006725 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 649831006726 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 649831006727 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 649831006728 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 649831006729 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 649831006730 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 649831006731 tetramer interface [polypeptide binding]; other site 649831006732 pyridoxal 5'-phosphate binding site [chemical binding]; other site 649831006733 catalytic residue [active] 649831006734 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 649831006735 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 649831006736 active site 649831006737 catalytic residues [active] 649831006738 PA_subtilisin_like: Protease-associated domain containing subtilisin-like proteases. This group contains various PA domain-containing subtilisin-like proteases including melon cucumisin, Arabidopsis thaliana Ara12, a nodule specific serine protease from...; Region: PA_subtilisin_like; cd02120 649831006739 PA/protease or protease-like domain interface [polypeptide binding]; other site 649831006740 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 649831006741 catalytic residues [active] 649831006742 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 649831006743 Predicted transcriptional regulators [Transcription]; Region: COG1733 649831006744 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 649831006745 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831006746 NADH(P)-binding; Region: NAD_binding_10; pfam13460 649831006747 NAD(P) binding site [chemical binding]; other site 649831006748 active site 649831006749 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 649831006750 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 649831006751 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 649831006752 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 649831006753 catalytic residues [active] 649831006754 catalytic nucleophile [active] 649831006755 Recombinase; Region: Recombinase; pfam07508 649831006756 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 649831006757 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 649831006758 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 649831006759 non-specific DNA binding site [nucleotide binding]; other site 649831006760 salt bridge; other site 649831006761 sequence-specific DNA binding site [nucleotide binding]; other site 649831006762 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 649831006763 nudix motif; other site 649831006764 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 649831006765 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 649831006766 Winged helix-turn helix; Region: HTH_29; pfam13551 649831006767 Integrase core domain; Region: rve; pfam00665 649831006768 Integrase core domain; Region: rve_3; pfam13683 649831006769 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 649831006770 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 649831006771 catalytic residues [active] 649831006772 catalytic nucleophile [active] 649831006773 Recombinase; Region: Recombinase; pfam07508 649831006774 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 649831006775 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 649831006776 dimer interface [polypeptide binding]; other site 649831006777 DJ-1 family protein; Region: not_thiJ; TIGR01383 649831006778 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 649831006779 conserved cys residue [active] 649831006780 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 649831006781 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 649831006782 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 649831006783 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 649831006784 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 649831006785 active site 649831006786 DNA binding site [nucleotide binding] 649831006787 Int/Topo IB signature motif; other site 649831006788 Homeodomain-like domain; Region: HTH_23; cl17451 649831006789 Winged helix-turn helix; Region: HTH_29; pfam13551 649831006790 Integrase core domain; Region: rve; pfam00665 649831006791 Integrase core domain; Region: rve_3; pfam13683 649831006792 Restriction endonuclease; Region: Mrr_cat; pfam04471 649831006793 Restriction endonuclease NaeI; Region: NaeI; pfam09126 649831006794 Tetratricopeptide repeat; Region: TPR_12; pfam13424 649831006795 Tetratricopeptide repeat; Region: TPR_12; pfam13424 649831006796 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 649831006797 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 649831006798 Walker A motif; other site 649831006799 ATP binding site [chemical binding]; other site 649831006800 Walker B motif; other site 649831006801 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 649831006802 substrate binding site [chemical binding]; other site 649831006803 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 649831006804 DNA binding site [nucleotide binding] 649831006805 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 649831006806 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 649831006807 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 649831006808 AAA domain; Region: AAA_12; pfam13087 649831006809 Protein of unknown function (Hypoth_ymh); Region: Hypoth_Ymh; pfam09509 649831006810 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 649831006811 nudix motif; other site 649831006812 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 649831006813 Cellulose binding domain; Region: CBM_2; pfam00553 649831006814 Alpha-L-arabinofuranosidase B, catalytic; Region: ArabFuran-catal; pfam09206 649831006815 alpha-galactosidase; Region: PLN02808; cl17638 649831006816 CBD_II domain; Region: CBD_II; smart00637 649831006817 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 649831006818 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649831006819 dimer interface [polypeptide binding]; other site 649831006820 conserved gate region; other site 649831006821 putative PBP binding loops; other site 649831006822 ABC-ATPase subunit interface; other site 649831006823 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649831006824 dimer interface [polypeptide binding]; other site 649831006825 conserved gate region; other site 649831006826 putative PBP binding loops; other site 649831006827 ABC-ATPase subunit interface; other site 649831006828 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 649831006829 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 649831006830 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 649831006831 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 649831006832 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 649831006833 nucleotide binding site [chemical binding]; other site 649831006834 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 649831006835 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 649831006836 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 649831006837 Probable beta-xylosidase; Provisional; Region: PLN03080 649831006838 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 649831006839 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 649831006840 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 649831006841 Homeodomain-like domain; Region: HTH_23; cl17451 649831006842 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 649831006843 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 649831006844 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 649831006845 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 649831006846 phosphate binding site [ion binding]; other site 649831006847 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 649831006848 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831006849 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 649831006850 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649831006851 S-adenosylmethionine binding site [chemical binding]; other site 649831006852 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 649831006853 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 649831006854 sequence-specific DNA binding site [nucleotide binding]; other site 649831006855 salt bridge; other site 649831006856 Cupin domain; Region: Cupin_2; pfam07883 649831006857 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 649831006858 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 649831006859 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 649831006860 active site 649831006861 DNA binding site [nucleotide binding] 649831006862 Int/Topo IB signature motif; other site 649831006863 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 649831006864 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 649831006865 putative hydrophobic ligand binding site [chemical binding]; other site 649831006866 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 649831006867 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 649831006868 NAD binding site [chemical binding]; other site 649831006869 catalytic Zn binding site [ion binding]; other site 649831006870 structural Zn binding site [ion binding]; other site 649831006871 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015 649831006872 Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206 649831006873 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 649831006874 active site 649831006875 substrate binding sites [chemical binding]; other site 649831006876 YCII-related domain; Region: YCII; cl00999 649831006877 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 649831006878 MbtH-like protein; Region: MbtH; cl01279 649831006879 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 649831006880 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 649831006881 acyl-activating enzyme (AAE) consensus motif; other site 649831006882 AMP binding site [chemical binding]; other site 649831006883 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 649831006884 Condensation domain; Region: Condensation; pfam00668 649831006885 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 649831006886 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 649831006887 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 649831006888 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 649831006889 catalytic residue [active] 649831006890 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 649831006891 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 649831006892 acyl-activating enzyme (AAE) consensus motif; other site 649831006893 active site 649831006894 AMP binding site [chemical binding]; other site 649831006895 CoA binding site [chemical binding]; other site 649831006896 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 649831006897 active site 649831006898 iron coordination sites [ion binding]; other site 649831006899 Condensation domain; Region: Condensation; pfam00668 649831006900 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 649831006901 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 649831006902 acyl-activating enzyme (AAE) consensus motif; other site 649831006903 AMP binding site [chemical binding]; other site 649831006904 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 649831006905 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831006906 H+ Antiporter protein; Region: 2A0121; TIGR00900 649831006907 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 649831006908 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831006909 Major Facilitator Superfamily; Region: MFS_1; pfam07690 649831006910 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 649831006911 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 649831006912 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 649831006913 O-methyltransferase; Region: Methyltransf_2; pfam00891 649831006914 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 649831006915 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831006916 putative substrate translocation pore; other site 649831006917 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 649831006918 Cellulose binding domain; Region: CBM_2; pfam00553 649831006919 short chain dehydrogenase; Provisional; Region: PRK06197 649831006920 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 649831006921 putative NAD(P) binding site [chemical binding]; other site 649831006922 active site 649831006923 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 649831006924 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831006925 NAD(P) binding site [chemical binding]; other site 649831006926 active site 649831006927 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 649831006928 SnoaL-like domain; Region: SnoaL_3; pfam13474 649831006929 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 649831006930 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 649831006931 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 649831006932 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831006933 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 649831006934 Trehalase; Region: Trehalase; cl17346 649831006935 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 649831006936 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649831006937 dimer interface [polypeptide binding]; other site 649831006938 conserved gate region; other site 649831006939 putative PBP binding loops; other site 649831006940 ABC-ATPase subunit interface; other site 649831006941 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 649831006942 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649831006943 dimer interface [polypeptide binding]; other site 649831006944 conserved gate region; other site 649831006945 putative PBP binding loops; other site 649831006946 ABC-ATPase subunit interface; other site 649831006947 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 649831006948 Transcriptional regulators [Transcription]; Region: PurR; COG1609 649831006949 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 649831006950 DNA binding site [nucleotide binding] 649831006951 domain linker motif; other site 649831006952 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 649831006953 dimerization interface [polypeptide binding]; other site 649831006954 ligand binding site [chemical binding]; other site 649831006955 Ricin-type beta-trefoil; Region: RICIN; smart00458 649831006956 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 649831006957 putative sugar binding sites [chemical binding]; other site 649831006958 Q-X-W motif; other site 649831006959 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 649831006960 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 649831006961 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 649831006962 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 649831006963 Soluble P-type ATPase [General function prediction only]; Region: COG4087 649831006964 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 649831006965 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 649831006966 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 649831006967 potential catalytic triad [active] 649831006968 conserved cys residue [active] 649831006969 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 649831006970 Domain of unknown function (DUF4345); Region: DUF4345; pfam14248 649831006971 Predicted transcriptional regulators [Transcription]; Region: COG1733 649831006972 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 649831006973 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831006974 NADH(P)-binding; Region: NAD_binding_10; pfam13460 649831006975 NAD(P) binding site [chemical binding]; other site 649831006976 active site 649831006977 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649831006978 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831006979 active site 649831006980 phosphorylation site [posttranslational modification] 649831006981 intermolecular recognition site; other site 649831006982 dimerization interface [polypeptide binding]; other site 649831006983 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649831006984 DNA binding residues [nucleotide binding] 649831006985 dimerization interface [polypeptide binding]; other site 649831006986 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 649831006987 ATP binding site [chemical binding]; other site 649831006988 Mg2+ binding site [ion binding]; other site 649831006989 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 649831006990 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 649831006991 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 649831006992 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 649831006993 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 649831006994 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 649831006995 Fungalysin metallopeptidase (M36); Region: Peptidase_M36; pfam02128 649831006996 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 649831006997 Zn binding site [ion binding]; other site 649831006998 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 649831006999 AAA ATPase domain; Region: AAA_16; pfam13191 649831007000 NB-ARC domain; Region: NB-ARC; pfam00931 649831007001 Tetratricopeptide repeat; Region: TPR_12; pfam13424 649831007002 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 649831007003 Catalytic domain of Protein Kinases; Region: PKc; cd00180 649831007004 active site 649831007005 ATP binding site [chemical binding]; other site 649831007006 substrate binding site [chemical binding]; other site 649831007007 activation loop (A-loop); other site 649831007008 Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cl00187 649831007009 PKC phosphorylation site [posttranslational modification]; other site 649831007010 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 649831007011 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 649831007012 DNA binding site [nucleotide binding] 649831007013 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 649831007014 cyclase homology domain; Region: CHD; cd07302 649831007015 nucleotidyl binding site; other site 649831007016 dimer interface [polypeptide binding]; other site 649831007017 TOMM system kinase/cyclase fusion protein; Region: TOMM_kin_cyc; TIGR03903 649831007018 metal binding site [ion binding]; metal-binding site 649831007019 AAA ATPase domain; Region: AAA_16; pfam13191 649831007020 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 649831007021 active site 649831007022 catalytic triad [active] 649831007023 oxyanion hole [active] 649831007024 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 649831007025 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 649831007026 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831007027 active site 649831007028 phosphorylation site [posttranslational modification] 649831007029 intermolecular recognition site; other site 649831007030 dimerization interface [polypeptide binding]; other site 649831007031 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 649831007032 DNA binding site [nucleotide binding] 649831007033 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 649831007034 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 649831007035 dimerization interface [polypeptide binding]; other site 649831007036 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 649831007037 dimer interface [polypeptide binding]; other site 649831007038 phosphorylation site [posttranslational modification] 649831007039 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831007040 ATP binding site [chemical binding]; other site 649831007041 Mg2+ binding site [ion binding]; other site 649831007042 G-X-G motif; other site 649831007043 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 649831007044 active site 649831007045 catalytic triad [active] 649831007046 oxyanion hole [active] 649831007047 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 649831007048 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 649831007049 putative sugar binding sites [chemical binding]; other site 649831007050 Q-X-W motif; other site 649831007051 Uncharacterized conserved protein [Function unknown]; Region: COG2128 649831007052 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 649831007053 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 649831007054 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 649831007055 DNA binding residues [nucleotide binding] 649831007056 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831007057 Major Facilitator Superfamily; Region: MFS_1; pfam07690 649831007058 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 649831007059 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 649831007060 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 649831007061 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 649831007062 DNA binding residues [nucleotide binding] 649831007063 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 649831007064 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831007065 NADH(P)-binding; Region: NAD_binding_10; pfam13460 649831007066 NAD(P) binding site [chemical binding]; other site 649831007067 short chain dehydrogenase; Provisional; Region: PRK12828 649831007068 classical (c) SDRs; Region: SDR_c; cd05233 649831007069 NAD(P) binding site [chemical binding]; other site 649831007070 active site 649831007071 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 649831007072 MarR family; Region: MarR; pfam01047 649831007073 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 649831007074 salt bridge; other site 649831007075 non-specific DNA binding site [nucleotide binding]; other site 649831007076 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 649831007077 sequence-specific DNA binding site [nucleotide binding]; other site 649831007078 short chain dehydrogenase; Provisional; Region: PRK08263 649831007079 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 649831007080 NADP binding site [chemical binding]; other site 649831007081 active site 649831007082 steroid binding site; other site 649831007083 Transcriptional regulator [Transcription]; Region: LysR; COG0583 649831007084 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 649831007085 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 649831007086 dimerization interface [polypeptide binding]; other site 649831007087 substrate binding pocket [chemical binding]; other site 649831007088 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 649831007089 classical (c) SDRs; Region: SDR_c; cd05233 649831007090 NAD(P) binding site [chemical binding]; other site 649831007091 active site 649831007092 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 649831007093 active site 649831007094 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 649831007095 glycerate dehydrogenase; Provisional; Region: PRK06932 649831007096 NAD binding site [chemical binding]; other site 649831007097 ligand binding site [chemical binding]; other site 649831007098 catalytic site [active] 649831007099 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 649831007100 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 649831007101 active site 649831007102 inhibitor site; inhibition site 649831007103 dimer interface [polypeptide binding]; other site 649831007104 catalytic residue [active] 649831007105 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831007106 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 649831007107 NAD(P) binding site [chemical binding]; other site 649831007108 active site 649831007109 aspartate aminotransferase; Provisional; Region: PRK05764 649831007110 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 649831007111 pyridoxal 5'-phosphate binding site [chemical binding]; other site 649831007112 homodimer interface [polypeptide binding]; other site 649831007113 catalytic residue [active] 649831007114 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 649831007115 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 649831007116 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 649831007117 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 649831007118 Walker A/P-loop; other site 649831007119 ATP binding site [chemical binding]; other site 649831007120 Q-loop/lid; other site 649831007121 ABC transporter signature motif; other site 649831007122 Walker B; other site 649831007123 D-loop; other site 649831007124 H-loop/switch region; other site 649831007125 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 649831007126 D-ala-D-ala transporter subunit; Provisional; Region: PRK09881 649831007127 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649831007128 dimer interface [polypeptide binding]; other site 649831007129 conserved gate region; other site 649831007130 putative PBP binding loops; other site 649831007131 ABC-ATPase subunit interface; other site 649831007132 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 649831007133 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649831007134 dimer interface [polypeptide binding]; other site 649831007135 conserved gate region; other site 649831007136 putative PBP binding loops; other site 649831007137 ABC-ATPase subunit interface; other site 649831007138 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 649831007139 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 649831007140 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 649831007141 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 649831007142 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 649831007143 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 649831007144 DNA-binding site [nucleotide binding]; DNA binding site 649831007145 FCD domain; Region: FCD; pfam07729 649831007146 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 649831007147 Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564 649831007148 active site 649831007149 Probable beta-xylosidase; Provisional; Region: PLN03080 649831007150 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 649831007151 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 649831007152 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 649831007153 anti sigma factor interaction site; other site 649831007154 regulatory phosphorylation site [posttranslational modification]; other site 649831007155 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 649831007156 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 649831007157 Mg2+ binding site [ion binding]; other site 649831007158 G-X-G motif; other site 649831007159 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 649831007160 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 649831007161 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 649831007162 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 649831007163 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 649831007164 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 649831007165 MarR family; Region: MarR_2; cl17246 649831007166 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 649831007167 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 649831007168 Glucose dehydrogenase; Region: glucose_DH; cd08230 649831007169 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 649831007170 NADP binding site [chemical binding]; other site 649831007171 catalytic Zn binding site [ion binding]; other site 649831007172 structural Zn binding site [ion binding]; other site 649831007173 dimer interface [polypeptide binding]; other site 649831007174 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 649831007175 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 649831007176 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 649831007177 [4Fe-4S] binding site [ion binding]; other site 649831007178 molybdopterin cofactor binding site; other site 649831007179 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 649831007180 molybdopterin cofactor binding site; other site 649831007181 HPP family; Region: HPP; pfam04982 649831007182 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 649831007183 anti sigma factor interaction site; other site 649831007184 regulatory phosphorylation site [posttranslational modification]; other site 649831007185 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 649831007186 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 649831007187 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 649831007188 BON domain; Region: BON; pfam04972 649831007189 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 649831007190 anti sigma factor interaction site; other site 649831007191 regulatory phosphorylation site [posttranslational modification]; other site 649831007192 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 649831007193 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 649831007194 transmembrane helices; other site 649831007195 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 649831007196 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 649831007197 Catalytic domain of Protein Kinases; Region: PKc; cd00180 649831007198 active site 649831007199 ATP binding site [chemical binding]; other site 649831007200 substrate binding site [chemical binding]; other site 649831007201 activation loop (A-loop); other site 649831007202 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 649831007203 Catalytic domain of Protein Kinases; Region: PKc; cd00180 649831007204 active site 649831007205 ATP binding site [chemical binding]; other site 649831007206 substrate binding site [chemical binding]; other site 649831007207 activation loop (A-loop); other site 649831007208 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 649831007209 anti sigma factor interaction site; other site 649831007210 regulatory phosphorylation site [posttranslational modification]; other site 649831007211 PRC-barrel domain; Region: PRC; pfam05239 649831007212 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 649831007213 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 649831007214 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 649831007215 active site 649831007216 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 649831007217 Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; pfam10069 649831007218 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 649831007219 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 649831007220 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831007221 Epoxide hydrolase N terminus; Region: EHN; pfam06441 649831007222 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 649831007223 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 649831007224 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 649831007225 putative sugar binding sites [chemical binding]; other site 649831007226 Q-X-W motif; other site 649831007227 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 649831007228 NAD binding pocket [chemical binding]; other site 649831007229 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 649831007230 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 649831007231 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 649831007232 Predicted transcriptional regulators [Transcription]; Region: COG1733 649831007233 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 649831007234 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831007235 NADH(P)-binding; Region: NAD_binding_10; pfam13460 649831007236 NAD(P) binding site [chemical binding]; other site 649831007237 active site 649831007238 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 649831007239 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 649831007240 dimerization interface [polypeptide binding]; other site 649831007241 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 649831007242 dimer interface [polypeptide binding]; other site 649831007243 phosphorylation site [posttranslational modification] 649831007244 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831007245 ATP binding site [chemical binding]; other site 649831007246 Mg2+ binding site [ion binding]; other site 649831007247 G-X-G motif; other site 649831007248 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 649831007249 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831007250 active site 649831007251 phosphorylation site [posttranslational modification] 649831007252 intermolecular recognition site; other site 649831007253 dimerization interface [polypeptide binding]; other site 649831007254 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 649831007255 DNA binding site [nucleotide binding] 649831007256 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 649831007257 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 649831007258 Walker A/P-loop; other site 649831007259 ATP binding site [chemical binding]; other site 649831007260 Q-loop/lid; other site 649831007261 ABC transporter signature motif; other site 649831007262 Walker B; other site 649831007263 D-loop; other site 649831007264 H-loop/switch region; other site 649831007265 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 649831007266 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 649831007267 FtsX-like permease family; Region: FtsX; pfam02687 649831007268 Transcriptional regulator [Transcription]; Region: LysR; COG0583 649831007269 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 649831007270 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 649831007271 dimerization interface [polypeptide binding]; other site 649831007272 short chain dehydrogenase; Provisional; Region: PRK09291 649831007273 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831007274 NAD(P) binding site [chemical binding]; other site 649831007275 active site 649831007276 malate dehydrogenase; Provisional; Region: PRK13529 649831007277 Malic enzyme, N-terminal domain; Region: malic; pfam00390 649831007278 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 649831007279 NAD(P) binding site [chemical binding]; other site 649831007280 fumarate hydratase; Reviewed; Region: fumC; PRK00485 649831007281 Class II fumarases; Region: Fumarase_classII; cd01362 649831007282 active site 649831007283 tetramer interface [polypeptide binding]; other site 649831007284 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 649831007285 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 649831007286 sequence-specific DNA binding site [nucleotide binding]; other site 649831007287 salt bridge; other site 649831007288 short chain dehydrogenase; Provisional; Region: PRK05854 649831007289 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831007290 NAD(P) binding site [chemical binding]; other site 649831007291 active site 649831007292 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 649831007293 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 649831007294 dimerization interface [polypeptide binding]; other site 649831007295 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 649831007296 dimer interface [polypeptide binding]; other site 649831007297 putative CheW interface [polypeptide binding]; other site 649831007298 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 649831007299 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831007300 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 649831007301 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 649831007302 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 649831007303 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 649831007304 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 649831007305 NAD(P) binding site [chemical binding]; other site 649831007306 homodimer interface [polypeptide binding]; other site 649831007307 substrate binding site [chemical binding]; other site 649831007308 active site 649831007309 Chain length determinant protein; Region: Wzz; cl15801 649831007310 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 649831007311 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 649831007312 Nucleotide binding site [chemical binding]; other site 649831007313 P loop; other site 649831007314 DTAP/Switch II; other site 649831007315 Switch I; other site 649831007316 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 649831007317 Mg++ binding site [ion binding]; other site 649831007318 putative catalytic motif [active] 649831007319 putative substrate binding site [chemical binding]; other site 649831007320 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 649831007321 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 649831007322 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831007323 active site 649831007324 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 649831007325 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831007326 NAD(P) binding site [chemical binding]; other site 649831007327 active site 649831007328 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 649831007329 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 649831007330 active site 649831007331 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 649831007332 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 649831007333 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 649831007334 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 649831007335 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 649831007336 Protein of unknown function (DUF4012); Region: DUF4012; pfam13196 649831007337 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 649831007338 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 649831007339 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 649831007340 Cellulose binding domain; Region: CBM_2; pfam00553 649831007341 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649831007342 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649831007343 DNA binding residues [nucleotide binding] 649831007344 dimerization interface [polypeptide binding]; other site 649831007345 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 649831007346 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 649831007347 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 649831007348 short chain dehydrogenase; Provisional; Region: PRK12828 649831007349 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831007350 NAD(P) binding site [chemical binding]; other site 649831007351 active site 649831007352 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 649831007353 Protein of unknown function (DUF1211); Region: DUF1211; pfam06736 649831007354 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 649831007355 Zeta-crystallin with NADP-dependent quinone reductase activity (QOR); Region: zeta_crystallin; cd08253 649831007356 NAD(P) binding site [chemical binding]; other site 649831007357 AAA ATPase domain; Region: AAA_16; pfam13191 649831007358 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649831007359 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649831007360 DNA binding residues [nucleotide binding] 649831007361 Transcriptional regulators [Transcription]; Region: MarR; COG1846 649831007362 MarR family; Region: MarR_2; pfam12802 649831007363 short chain dehydrogenase; Provisional; Region: PRK06180 649831007364 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 649831007365 NADP binding site [chemical binding]; other site 649831007366 active site 649831007367 steroid binding site; other site 649831007368 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 649831007369 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 649831007370 dimer interface [polypeptide binding]; other site 649831007371 active site 649831007372 Transcriptional regulator [Transcription]; Region: LysR; COG0583 649831007373 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 649831007374 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 649831007375 dimerization interface [polypeptide binding]; other site 649831007376 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831007377 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 649831007378 NAD(P) binding site [chemical binding]; other site 649831007379 active site 649831007380 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 649831007381 Cupin; Region: Cupin_6; pfam12852 649831007382 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 649831007383 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 649831007384 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649831007385 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831007386 active site 649831007387 phosphorylation site [posttranslational modification] 649831007388 intermolecular recognition site; other site 649831007389 dimerization interface [polypeptide binding]; other site 649831007390 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649831007391 DNA binding residues [nucleotide binding] 649831007392 dimerization interface [polypeptide binding]; other site 649831007393 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 649831007394 Histidine kinase; Region: HisKA_3; pfam07730 649831007395 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 649831007396 ATP binding site [chemical binding]; other site 649831007397 Mg2+ binding site [ion binding]; other site 649831007398 G-X-G motif; other site 649831007399 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 649831007400 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 649831007401 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 649831007402 DNA binding residues [nucleotide binding] 649831007403 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649831007404 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649831007405 DNA binding residues [nucleotide binding] 649831007406 dimerization interface [polypeptide binding]; other site 649831007407 Putative zinc-finger; Region: zf-HC2; pfam13490 649831007408 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 649831007409 Histidine kinase; Region: HisKA_3; pfam07730 649831007410 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649831007411 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831007412 active site 649831007413 phosphorylation site [posttranslational modification] 649831007414 intermolecular recognition site; other site 649831007415 dimerization interface [polypeptide binding]; other site 649831007416 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649831007417 DNA binding residues [nucleotide binding] 649831007418 dimerization interface [polypeptide binding]; other site 649831007419 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 649831007420 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 649831007421 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 649831007422 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 649831007423 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831007424 active site 649831007425 phosphorylation site [posttranslational modification] 649831007426 intermolecular recognition site; other site 649831007427 dimerization interface [polypeptide binding]; other site 649831007428 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 649831007429 DNA binding site [nucleotide binding] 649831007430 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 649831007431 dimerization interface [polypeptide binding]; other site 649831007432 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 649831007433 dimer interface [polypeptide binding]; other site 649831007434 phosphorylation site [posttranslational modification] 649831007435 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831007436 ATP binding site [chemical binding]; other site 649831007437 Mg2+ binding site [ion binding]; other site 649831007438 G-X-G motif; other site 649831007439 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 649831007440 active site 649831007441 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 649831007442 HAMP domain; Region: HAMP; pfam00672 649831007443 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 649831007444 putative CheW interface [polypeptide binding]; other site 649831007445 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 649831007446 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 649831007447 active site 649831007448 Condensation domain; Region: Condensation; pfam00668 649831007449 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu_like; cd11331 649831007450 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 649831007451 active site 649831007452 catalytic site [active] 649831007453 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 649831007454 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 649831007455 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 649831007456 active site 649831007457 catalytic tetrad [active] 649831007458 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 649831007459 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 649831007460 TIGR03032 family protein; Region: TIGR03032 649831007461 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 649831007462 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 649831007463 PYR/PP interface [polypeptide binding]; other site 649831007464 dimer interface [polypeptide binding]; other site 649831007465 TPP binding site [chemical binding]; other site 649831007466 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 649831007467 TPP-binding site [chemical binding]; other site 649831007468 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 649831007469 acyl carrier protein; Provisional; Region: PRK07081 649831007470 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 649831007471 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 649831007472 Glutamine amidotransferase class-I; Region: GATase; pfam00117 649831007473 glutamine binding [chemical binding]; other site 649831007474 catalytic triad [active] 649831007475 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 649831007476 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 649831007477 chorismate binding enzyme; Region: Chorismate_bind; cl10555 649831007478 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 649831007479 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 649831007480 dimer interface [polypeptide binding]; other site 649831007481 active site 649831007482 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 649831007483 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 649831007484 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 649831007485 acyl-activating enzyme (AAE) consensus motif; other site 649831007486 acyl-activating enzyme (AAE) consensus motif; other site 649831007487 AMP binding site [chemical binding]; other site 649831007488 active site 649831007489 CoA binding site [chemical binding]; other site 649831007490 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649831007491 S-adenosylmethionine binding site [chemical binding]; other site 649831007492 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 649831007493 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 649831007494 acyl-activating enzyme (AAE) consensus motif; other site 649831007495 AMP binding site [chemical binding]; other site 649831007496 H+ Antiporter protein; Region: 2A0121; TIGR00900 649831007497 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 649831007498 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 649831007499 substrate binding pocket [chemical binding]; other site 649831007500 active site 649831007501 iron coordination sites [ion binding]; other site 649831007502 Caspase domain; Region: Peptidase_C14; pfam00656 649831007503 acyl-CoA synthetase; Validated; Region: PRK05850 649831007504 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 649831007505 acyl-activating enzyme (AAE) consensus motif; other site 649831007506 active site 649831007507 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831007508 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831007509 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 649831007510 active site 649831007511 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831007512 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831007513 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 649831007514 active site 649831007515 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 649831007516 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 649831007517 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 649831007518 KR domain; Region: KR; pfam08659 649831007519 NADP binding site [chemical binding]; other site 649831007520 active site 649831007521 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831007522 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831007523 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 649831007524 active site 649831007525 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 649831007526 thioester reductase domain; Region: Thioester-redct; TIGR01746 649831007527 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831007528 NAD(P) binding site [chemical binding]; other site 649831007529 active site 649831007530 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 649831007531 Cytochrome P450; Region: p450; cl12078 649831007532 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 649831007533 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 649831007534 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831007535 short chain dehydrogenase; Provisional; Region: PRK06197 649831007536 NAD(P) binding site [chemical binding]; other site 649831007537 active site 649831007538 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 649831007539 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 649831007540 crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751 649831007541 NAD(P) binding site [chemical binding]; other site 649831007542 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 649831007543 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 649831007544 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 649831007545 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 649831007546 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 649831007547 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 649831007548 Dehydroquinase class II; Region: DHquinase_II; pfam01220 649831007549 active site 649831007550 trimer interface [polypeptide binding]; other site 649831007551 dimer interface [polypeptide binding]; other site 649831007552 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 649831007553 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 649831007554 inhibitor-cofactor binding pocket; inhibition site 649831007555 pyridoxal 5'-phosphate binding site [chemical binding]; other site 649831007556 catalytic residue [active] 649831007557 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 649831007558 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 649831007559 3-amino-5-hydroxybenoic acid synthesis related protein; Region: AHBA_synth_RP; TIGR01454 649831007560 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 649831007561 motif II; other site 649831007562 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 649831007563 active site 649831007564 dimer interface [polypeptide binding]; other site 649831007565 metal binding site [ion binding]; metal-binding site 649831007566 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 649831007567 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 649831007568 acyl-activating enzyme (AAE) consensus motif; other site 649831007569 AMP binding site [chemical binding]; other site 649831007570 active site 649831007571 CoA binding site [chemical binding]; other site 649831007572 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 649831007573 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 649831007574 putative NADP binding site [chemical binding]; other site 649831007575 active site 649831007576 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831007577 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831007578 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 649831007579 active site 649831007580 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 649831007581 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 649831007582 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 649831007583 putative NADP binding site [chemical binding]; other site 649831007584 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 649831007585 active site 649831007586 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831007587 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 649831007588 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831007589 active site 649831007590 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 649831007591 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 649831007592 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 649831007593 NADP binding site [chemical binding]; other site 649831007594 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 649831007595 active site 649831007596 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831007597 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 649831007598 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831007599 active site 649831007600 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 649831007601 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 649831007602 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831007603 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 649831007604 Enoylreductase; Region: PKS_ER; smart00829 649831007605 NAD(P) binding site [chemical binding]; other site 649831007606 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 649831007607 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 649831007608 putative NADP binding site [chemical binding]; other site 649831007609 active site 649831007610 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831007611 Erythronolide synthase docking; Region: Docking; pfam08990 649831007612 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 649831007613 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831007614 active site 649831007615 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 649831007616 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 649831007617 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 649831007618 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 649831007619 putative NADP binding site [chemical binding]; other site 649831007620 active site 649831007621 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831007622 Erythronolide synthase docking; Region: Docking; pfam08990 649831007623 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831007624 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 649831007625 active site 649831007626 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 649831007627 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 649831007628 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 649831007629 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831007630 Enoylreductase; Region: PKS_ER; smart00829 649831007631 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 649831007632 NAD(P) binding site [chemical binding]; other site 649831007633 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 649831007634 putative NADP binding site [chemical binding]; other site 649831007635 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 649831007636 active site 649831007637 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831007638 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831007639 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 649831007640 active site 649831007641 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 649831007642 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 649831007643 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831007644 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 649831007645 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831007646 active site 649831007647 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 649831007648 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 649831007649 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 649831007650 putative NADP binding site [chemical binding]; other site 649831007651 KR domain; Region: KR; pfam08659 649831007652 active site 649831007653 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831007654 N-acetyltransferase; Region: Acetyltransf_2; cl00949 649831007655 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 649831007656 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 649831007657 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 649831007658 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 649831007659 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 649831007660 Cytochrome P450; Region: p450; cl12078 649831007661 AAA ATPase domain; Region: AAA_16; pfam13191 649831007662 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649831007663 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649831007664 DNA binding residues [nucleotide binding] 649831007665 dimerization interface [polypeptide binding]; other site 649831007666 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 649831007667 putative FMN binding site [chemical binding]; other site 649831007668 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 649831007669 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 649831007670 NADP binding site [chemical binding]; other site 649831007671 dimer interface [polypeptide binding]; other site 649831007672 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 649831007673 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 649831007674 DNA binding site [nucleotide binding] 649831007675 Bacterial transcriptional activator domain; Region: BTAD; smart01043 649831007676 Protein of unknown function (DUF1110); Region: DUF1110; pfam06533 649831007677 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cd00413 649831007678 active site 649831007679 catalytic residues [active] 649831007680 Predicted membrane protein [Function unknown]; Region: COG2855 649831007681 Transcriptional regulator [Transcription]; Region: LysR; COG0583 649831007682 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 649831007683 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 649831007684 dimerization interface [polypeptide binding]; other site 649831007685 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 649831007686 anti sigma factor interaction site; other site 649831007687 regulatory phosphorylation site [posttranslational modification]; other site 649831007688 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 649831007689 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831007690 active site 649831007691 phosphorylation site [posttranslational modification] 649831007692 intermolecular recognition site; other site 649831007693 dimerization interface [polypeptide binding]; other site 649831007694 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 649831007695 DNA binding site [nucleotide binding] 649831007696 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 649831007697 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 649831007698 dimerization interface [polypeptide binding]; other site 649831007699 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 649831007700 dimer interface [polypeptide binding]; other site 649831007701 phosphorylation site [posttranslational modification] 649831007702 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831007703 ATP binding site [chemical binding]; other site 649831007704 Mg2+ binding site [ion binding]; other site 649831007705 G-X-G motif; other site 649831007706 Sporulation and spore germination; Region: Germane; pfam10646 649831007707 BON domain; Region: BON; pfam04972 649831007708 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 649831007709 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 649831007710 NAD binding site [chemical binding]; other site 649831007711 catalytic Zn binding site [ion binding]; other site 649831007712 structural Zn binding site [ion binding]; other site 649831007713 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 649831007714 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831007715 putative substrate translocation pore; other site 649831007716 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 649831007717 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 649831007718 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 649831007719 active site 649831007720 metal binding site [ion binding]; metal-binding site 649831007721 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 649831007722 CHASE3 domain; Region: CHASE3; pfam05227 649831007723 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 649831007724 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 649831007725 dimer interface [polypeptide binding]; other site 649831007726 phosphorylation site [posttranslational modification] 649831007727 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831007728 ATP binding site [chemical binding]; other site 649831007729 Mg2+ binding site [ion binding]; other site 649831007730 G-X-G motif; other site 649831007731 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831007732 Response regulator receiver domain; Region: Response_reg; pfam00072 649831007733 active site 649831007734 phosphorylation site [posttranslational modification] 649831007735 intermolecular recognition site; other site 649831007736 dimerization interface [polypeptide binding]; other site 649831007737 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831007738 Response regulator receiver domain; Region: Response_reg; pfam00072 649831007739 active site 649831007740 phosphorylation site [posttranslational modification] 649831007741 intermolecular recognition site; other site 649831007742 dimerization interface [polypeptide binding]; other site 649831007743 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 649831007744 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 649831007745 metal binding site [ion binding]; metal-binding site 649831007746 active site 649831007747 I-site; other site 649831007748 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 649831007749 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 649831007750 putative NAD(P) binding site [chemical binding]; other site 649831007751 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 649831007752 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 649831007753 DNA binding residues [nucleotide binding] 649831007754 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 649831007755 substrate binding site [chemical binding]; other site 649831007756 oxyanion hole (OAH) forming residues; other site 649831007757 trimer interface [polypeptide binding]; other site 649831007758 Predicted transcriptional regulators [Transcription]; Region: COG1733 649831007759 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 649831007760 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831007761 hypothetical protein; Provisional; Region: PRK06184 649831007762 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 649831007763 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 649831007764 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 649831007765 TAP-like protein; Region: Abhydrolase_4; pfam08386 649831007766 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 649831007767 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649831007768 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831007769 active site 649831007770 phosphorylation site [posttranslational modification] 649831007771 intermolecular recognition site; other site 649831007772 dimerization interface [polypeptide binding]; other site 649831007773 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649831007774 DNA binding residues [nucleotide binding] 649831007775 dimerization interface [polypeptide binding]; other site 649831007776 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 649831007777 Transcriptional regulator [Transcription]; Region: LysR; COG0583 649831007778 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 649831007779 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 649831007780 putative substrate binding pocket [chemical binding]; other site 649831007781 putative dimerization interface [polypeptide binding]; other site 649831007782 hypothetical protein; Provisional; Region: PRK06753 649831007783 hypothetical protein; Provisional; Region: PRK07236 649831007784 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 649831007785 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 649831007786 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 649831007787 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 649831007788 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 649831007789 MarR family; Region: MarR_2; pfam12802 649831007790 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 649831007791 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 649831007792 metal binding site [ion binding]; metal-binding site 649831007793 active site 649831007794 I-site; other site 649831007795 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 649831007796 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 649831007797 putative sugar binding sites [chemical binding]; other site 649831007798 Q-X-W motif; other site 649831007799 Alpha-L-arabinofuranosidase B, catalytic; Region: ArabFuran-catal; pfam09206 649831007800 alpha-galactosidase; Region: PLN02808; cl17638 649831007801 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 649831007802 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 649831007803 putative sugar binding sites [chemical binding]; other site 649831007804 Q-X-W motif; other site 649831007805 Cellulose binding domain; Region: CBM_2; pfam00553 649831007806 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649831007807 S-adenosylmethionine binding site [chemical binding]; other site 649831007808 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 649831007809 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649831007810 S-adenosylmethionine binding site [chemical binding]; other site 649831007811 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 649831007812 Cytochrome P450; Region: p450; cl12078 649831007813 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 649831007814 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 649831007815 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 649831007816 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 649831007817 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831007818 active site 649831007819 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 649831007820 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 649831007821 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 649831007822 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 649831007823 putative NADP binding site [chemical binding]; other site 649831007824 active site 649831007825 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831007826 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831007827 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 649831007828 active site 649831007829 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 649831007830 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 649831007831 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 649831007832 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 649831007833 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 649831007834 putative NADP binding site [chemical binding]; other site 649831007835 active site 649831007836 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831007837 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 649831007838 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831007839 active site 649831007840 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 649831007841 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 649831007842 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831007843 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 649831007844 Enoylreductase; Region: PKS_ER; smart00829 649831007845 NAD(P) binding site [chemical binding]; other site 649831007846 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 649831007847 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 649831007848 putative NADP binding site [chemical binding]; other site 649831007849 active site 649831007850 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831007851 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831007852 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 649831007853 active site 649831007854 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 649831007855 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 649831007856 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831007857 Condensation domain; Region: Condensation; pfam00668 649831007858 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 649831007859 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 649831007860 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 649831007861 acyl-activating enzyme (AAE) consensus motif; other site 649831007862 AMP binding site [chemical binding]; other site 649831007863 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 649831007864 Condensation domain; Region: Condensation; pfam00668 649831007865 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 649831007866 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 649831007867 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 649831007868 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 649831007869 acyl-activating enzyme (AAE) consensus motif; other site 649831007870 AMP binding site [chemical binding]; other site 649831007871 active site 649831007872 CoA binding site [chemical binding]; other site 649831007873 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 649831007874 Enoylreductase; Region: PKS_ER; smart00829 649831007875 NAD(P) binding site [chemical binding]; other site 649831007876 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831007877 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 649831007878 NAD(P) binding site [chemical binding]; other site 649831007879 active site 649831007880 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831007881 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 649831007882 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831007883 active site 649831007884 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 649831007885 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 649831007886 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831007887 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 649831007888 Enoylreductase; Region: PKS_ER; smart00829 649831007889 NAD(P) binding site [chemical binding]; other site 649831007890 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 649831007891 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 649831007892 putative NADP binding site [chemical binding]; other site 649831007893 active site 649831007894 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831007895 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 649831007896 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831007897 active site 649831007898 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 649831007899 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 649831007900 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 649831007901 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 649831007902 putative NADP binding site [chemical binding]; other site 649831007903 active site 649831007904 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831007905 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 649831007906 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831007907 active site 649831007908 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 649831007909 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 649831007910 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 649831007911 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 649831007912 putative NADP binding site [chemical binding]; other site 649831007913 active site 649831007914 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831007915 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 649831007916 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831007917 active site 649831007918 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 649831007919 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 649831007920 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 649831007921 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 649831007922 putative NADP binding site [chemical binding]; other site 649831007923 active site 649831007924 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831007925 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831007926 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 649831007927 active site 649831007928 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 649831007929 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 649831007930 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 649831007931 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 649831007932 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 649831007933 putative NADP binding site [chemical binding]; other site 649831007934 active site 649831007935 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831007936 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 649831007937 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831007938 active site 649831007939 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 649831007940 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 649831007941 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 649831007942 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 649831007943 putative NADP binding site [chemical binding]; other site 649831007944 active site 649831007945 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831007946 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 649831007947 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831007948 active site 649831007949 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 649831007950 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 649831007951 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831007952 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 649831007953 Enoylreductase; Region: PKS_ER; smart00829 649831007954 NAD(P) binding site [chemical binding]; other site 649831007955 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 649831007956 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 649831007957 putative NADP binding site [chemical binding]; other site 649831007958 active site 649831007959 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831007960 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 649831007961 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831007962 active site 649831007963 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 649831007964 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 649831007965 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 649831007966 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 649831007967 putative NADP binding site [chemical binding]; other site 649831007968 active site 649831007969 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831007970 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 649831007971 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831007972 active site 649831007973 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 649831007974 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 649831007975 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 649831007976 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 649831007977 putative NADP binding site [chemical binding]; other site 649831007978 active site 649831007979 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831007980 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 649831007981 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831007982 active site 649831007983 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 649831007984 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 649831007985 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 649831007986 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 649831007987 putative NADP binding site [chemical binding]; other site 649831007988 active site 649831007989 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831007990 AAA ATPase domain; Region: AAA_16; pfam13191 649831007991 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649831007992 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649831007993 DNA binding residues [nucleotide binding] 649831007994 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 649831007995 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 649831007996 Cytochrome P450; Region: p450; cl12078 649831007997 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_5; cd06153 649831007998 homotrimer interaction site [polypeptide binding]; other site 649831007999 putative active site [active] 649831008000 Ornithine cyclodeaminase/mu-crystallin family; Region: OCD_Mu_crystall; pfam02423 649831008001 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 649831008002 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 649831008003 Biofilm formation and stress response factor; Region: BsmA; pfam10014 649831008004 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 649831008005 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649831008006 S-adenosylmethionine binding site [chemical binding]; other site 649831008007 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 649831008008 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 649831008009 FeS/SAM binding site; other site 649831008010 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 649831008011 active site 649831008012 GTP cyclohydrolase I; Provisional; Region: PLN03044 649831008013 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 649831008014 active site 649831008015 Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820 649831008016 Predicted PP-loop superfamily ATPase [General function prediction only]; Region: COG0603 649831008017 Ligand Binding Site [chemical binding]; other site 649831008018 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 649831008019 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 649831008020 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 649831008021 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 649831008022 AMP-binding enzyme; Region: AMP-binding; pfam00501 649831008023 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 649831008024 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 649831008025 acyl-activating enzyme (AAE) consensus motif; other site 649831008026 acyl-activating enzyme (AAE) consensus motif; other site 649831008027 active site 649831008028 AMP binding site [chemical binding]; other site 649831008029 CoA binding site [chemical binding]; other site 649831008030 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 649831008031 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 649831008032 Major Facilitator Superfamily; Region: MFS_1; pfam07690 649831008033 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831008034 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 649831008035 Beta-lactamase; Region: Beta-lactamase; pfam00144 649831008036 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 649831008037 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831008038 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 649831008039 active site 649831008040 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 649831008041 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 649831008042 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 649831008043 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 649831008044 catalytic residue [active] 649831008045 natural product biosynthesis luciferase-like monooxygenase domain; Region: seco_metab_LLM; TIGR04020 649831008046 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 649831008047 Condensation domain; Region: Condensation; pfam00668 649831008048 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 649831008049 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 649831008050 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 649831008051 acyl-activating enzyme (AAE) consensus motif; other site 649831008052 AMP binding site [chemical binding]; other site 649831008053 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 649831008054 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 649831008055 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 649831008056 acyl-activating enzyme (AAE) consensus motif; other site 649831008057 AMP binding site [chemical binding]; other site 649831008058 active site 649831008059 CoA binding site [chemical binding]; other site 649831008060 Condensation domain; Region: Condensation; pfam00668 649831008061 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 649831008062 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 649831008063 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 649831008064 acyl-activating enzyme (AAE) consensus motif; other site 649831008065 AMP binding site [chemical binding]; other site 649831008066 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 649831008067 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 649831008068 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 649831008069 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 649831008070 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 649831008071 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 649831008072 dimer interface [polypeptide binding]; other site 649831008073 pyridoxal 5'-phosphate binding site [chemical binding]; other site 649831008074 catalytic residue [active] 649831008075 AAA ATPase domain; Region: AAA_16; pfam13191 649831008076 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649831008077 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649831008078 DNA binding residues [nucleotide binding] 649831008079 dimerization interface [polypeptide binding]; other site 649831008080 AAA ATPase domain; Region: AAA_16; pfam13191 649831008081 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649831008082 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649831008083 DNA binding residues [nucleotide binding] 649831008084 dimerization interface [polypeptide binding]; other site 649831008085 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 649831008086 Cytochrome P450; Region: p450; cl12078 649831008087 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 649831008088 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 649831008089 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 649831008090 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831008091 active site 649831008092 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 649831008093 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831008094 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 649831008095 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831008096 active site 649831008097 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 649831008098 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 649831008099 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 649831008100 putative NADP binding site [chemical binding]; other site 649831008101 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 649831008102 active site 649831008103 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831008104 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 649831008105 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831008106 active site 649831008107 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 649831008108 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 649831008109 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831008110 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 649831008111 Enoylreductase; Region: PKS_ER; smart00829 649831008112 NAD(P) binding site [chemical binding]; other site 649831008113 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 649831008114 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 649831008115 putative NADP binding site [chemical binding]; other site 649831008116 active site 649831008117 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831008118 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 649831008119 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831008120 active site 649831008121 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 649831008122 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 649831008123 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 649831008124 putative NADP binding site [chemical binding]; other site 649831008125 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 649831008126 active site 649831008127 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831008128 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 649831008129 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831008130 active site 649831008131 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 649831008132 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 649831008133 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831008134 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 649831008135 Enoylreductase; Region: PKS_ER; smart00829 649831008136 NAD(P) binding site [chemical binding]; other site 649831008137 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 649831008138 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 649831008139 putative NADP binding site [chemical binding]; other site 649831008140 active site 649831008141 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831008142 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 649831008143 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831008144 active site 649831008145 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 649831008146 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 649831008147 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831008148 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 649831008149 Enoylreductase; Region: PKS_ER; smart00829 649831008150 NAD(P) binding site [chemical binding]; other site 649831008151 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 649831008152 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 649831008153 putative NADP binding site [chemical binding]; other site 649831008154 active site 649831008155 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831008156 Erythronolide synthase docking; Region: Docking; pfam08990 649831008157 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 649831008158 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831008159 active site 649831008160 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 649831008161 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 649831008162 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 649831008163 putative NADP binding site [chemical binding]; other site 649831008164 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 649831008165 active site 649831008166 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831008167 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 649831008168 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831008169 active site 649831008170 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 649831008171 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 649831008172 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831008173 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 649831008174 Enoylreductase; Region: PKS_ER; smart00829 649831008175 NAD(P) binding site [chemical binding]; other site 649831008176 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 649831008177 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 649831008178 putative NADP binding site [chemical binding]; other site 649831008179 active site 649831008180 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831008181 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 649831008182 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831008183 active site 649831008184 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 649831008185 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 649831008186 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 649831008187 putative NADP binding site [chemical binding]; other site 649831008188 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 649831008189 active site 649831008190 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831008191 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 649831008192 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831008193 active site 649831008194 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 649831008195 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 649831008196 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 649831008197 putative NADP binding site [chemical binding]; other site 649831008198 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 649831008199 active site 649831008200 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831008201 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 649831008202 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831008203 active site 649831008204 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 649831008205 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 649831008206 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831008207 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 649831008208 Enoylreductase; Region: PKS_ER; smart00829 649831008209 NAD(P) binding site [chemical binding]; other site 649831008210 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 649831008211 KR domain; Region: KR; pfam08659 649831008212 putative NADP binding site [chemical binding]; other site 649831008213 active site 649831008214 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831008215 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 649831008216 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831008217 active site 649831008218 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 649831008219 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 649831008220 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 649831008221 putative NADP binding site [chemical binding]; other site 649831008222 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 649831008223 active site 649831008224 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831008225 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 649831008226 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831008227 active site 649831008228 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 649831008229 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 649831008230 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831008231 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 649831008232 Enoylreductase; Region: PKS_ER; smart00829 649831008233 NAD(P) binding site [chemical binding]; other site 649831008234 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 649831008235 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 649831008236 putative NADP binding site [chemical binding]; other site 649831008237 active site 649831008238 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831008239 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 649831008240 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831008241 active site 649831008242 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 649831008243 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 649831008244 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 649831008245 KR domain; Region: KR; pfam08659 649831008246 putative NADP binding site [chemical binding]; other site 649831008247 active site 649831008248 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831008249 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 649831008250 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831008251 active site 649831008252 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 649831008253 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 649831008254 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831008255 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 649831008256 Enoylreductase; Region: PKS_ER; smart00829 649831008257 NAD(P) binding site [chemical binding]; other site 649831008258 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 649831008259 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 649831008260 putative NADP binding site [chemical binding]; other site 649831008261 active site 649831008262 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831008263 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831008264 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 649831008265 active site 649831008266 Acyl transferase domain; Region: Acyl_transf_1; cl08282 649831008267 Acyl transferase domain; Region: Acyl_transf_1; cl08282 649831008268 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 649831008269 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 649831008270 acyl-activating enzyme (AAE) consensus motif; other site 649831008271 AMP binding site [chemical binding]; other site 649831008272 active site 649831008273 CoA binding site [chemical binding]; other site 649831008274 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 649831008275 Condensation domain; Region: Condensation; pfam00668 649831008276 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 649831008277 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 649831008278 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 649831008279 classical (c) SDRs; Region: SDR_c; cd05233 649831008280 NAD(P) binding site [chemical binding]; other site 649831008281 active site 649831008282 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 649831008283 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 649831008284 Methyltransferase domain; Region: Methyltransf_23; pfam13489 649831008285 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649831008286 S-adenosylmethionine binding site [chemical binding]; other site 649831008287 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 649831008288 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 649831008289 active site 649831008290 non-prolyl cis peptide bond; other site 649831008291 Response regulator receiver domain; Region: Response_reg; pfam00072 649831008292 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831008293 active site 649831008294 phosphorylation site [posttranslational modification] 649831008295 intermolecular recognition site; other site 649831008296 dimerization interface [polypeptide binding]; other site 649831008297 MASE1; Region: MASE1; cl17823 649831008298 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 649831008299 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 649831008300 dimer interface [polypeptide binding]; other site 649831008301 phosphorylation site [posttranslational modification] 649831008302 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831008303 ATP binding site [chemical binding]; other site 649831008304 Mg2+ binding site [ion binding]; other site 649831008305 G-X-G motif; other site 649831008306 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 649831008307 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 649831008308 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 649831008309 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 649831008310 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 649831008311 metal binding site [ion binding]; metal-binding site 649831008312 active site 649831008313 I-site; other site 649831008314 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 649831008315 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 649831008316 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 649831008317 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 649831008318 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 649831008319 salt bridge; other site 649831008320 non-specific DNA binding site [nucleotide binding]; other site 649831008321 sequence-specific DNA binding site [nucleotide binding]; other site 649831008322 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 649831008323 active site 1 [active] 649831008324 dimer interface [polypeptide binding]; other site 649831008325 hexamer interface [polypeptide binding]; other site 649831008326 active site 2 [active] 649831008327 A-factor biosynthesis hotdog domain; Region: AfsA; pfam03756 649831008328 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 649831008329 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 649831008330 motif II; other site 649831008331 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 649831008332 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 649831008333 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 649831008334 salt bridge; other site 649831008335 non-specific DNA binding site [nucleotide binding]; other site 649831008336 sequence-specific DNA binding site [nucleotide binding]; other site 649831008337 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 649831008338 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 649831008339 dimer interface [polypeptide binding]; other site 649831008340 active site 649831008341 CoA binding pocket [chemical binding]; other site 649831008342 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 649831008343 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 649831008344 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 649831008345 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 649831008346 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831008347 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 649831008348 salt bridge; other site 649831008349 non-specific DNA binding site [nucleotide binding]; other site 649831008350 sequence-specific DNA binding site [nucleotide binding]; other site 649831008351 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 649831008352 FAD binding site [chemical binding]; other site 649831008353 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 649831008354 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 649831008355 substrate binding site [chemical binding]; other site 649831008356 ATP binding site [chemical binding]; other site 649831008357 S-adenosylmethionine synthetase; Validated; Region: PRK05250 649831008358 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 649831008359 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 649831008360 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 649831008361 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649831008362 S-adenosylmethionine binding site [chemical binding]; other site 649831008363 PAS fold; Region: PAS; pfam00989 649831008364 PAS domain; Region: PAS; smart00091 649831008365 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 649831008366 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 649831008367 dimer interface [polypeptide binding]; other site 649831008368 phosphorylation site [posttranslational modification] 649831008369 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831008370 ATP binding site [chemical binding]; other site 649831008371 Mg2+ binding site [ion binding]; other site 649831008372 G-X-G motif; other site 649831008373 Response regulator receiver domain; Region: Response_reg; pfam00072 649831008374 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831008375 active site 649831008376 phosphorylation site [posttranslational modification] 649831008377 intermolecular recognition site; other site 649831008378 dimerization interface [polypeptide binding]; other site 649831008379 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 649831008380 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 649831008381 putative NAD(P) binding site [chemical binding]; other site 649831008382 Cupin domain; Region: Cupin_2; pfam07883 649831008383 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 649831008384 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 649831008385 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 649831008386 active site 649831008387 GAF domain; Region: GAF; pfam01590 649831008388 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 649831008389 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 649831008390 G2 box; other site 649831008391 Switch I region; other site 649831008392 G3 box; other site 649831008393 Switch II region; other site 649831008394 G4 box; other site 649831008395 Protein of unknown function (DUF742); Region: DUF742; pfam05331 649831008396 Roadblock/LC7 domain; Region: Robl_LC7; pfam03259 649831008397 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831008398 ATP binding site [chemical binding]; other site 649831008399 Mg2+ binding site [ion binding]; other site 649831008400 G-X-G motif; other site 649831008401 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 649831008402 homotrimer interaction site [polypeptide binding]; other site 649831008403 putative active site [active] 649831008404 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 649831008405 Condensation domain; Region: Condensation; pfam00668 649831008406 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 649831008407 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 649831008408 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 649831008409 acyl-activating enzyme (AAE) consensus motif; other site 649831008410 AMP binding site [chemical binding]; other site 649831008411 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 649831008412 Condensation domain; Region: Condensation; pfam00668 649831008413 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 649831008414 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 649831008415 Condensation domain; Region: Condensation; pfam00668 649831008416 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 649831008417 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 649831008418 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 649831008419 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 649831008420 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 649831008421 acyl-activating enzyme (AAE) consensus motif; other site 649831008422 AMP binding site [chemical binding]; other site 649831008423 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 649831008424 Protein of unknown function (DUF3455); Region: DUF3455; pfam11937 649831008425 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649831008426 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649831008427 DNA binding residues [nucleotide binding] 649831008428 dimerization interface [polypeptide binding]; other site 649831008429 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 649831008430 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 649831008431 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 649831008432 active site 649831008433 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 649831008434 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 649831008435 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 649831008436 putative ADP-binding pocket [chemical binding]; other site 649831008437 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 649831008438 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 649831008439 active site 649831008440 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 649831008441 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 649831008442 Walker A/P-loop; other site 649831008443 ATP binding site [chemical binding]; other site 649831008444 Q-loop/lid; other site 649831008445 ABC transporter signature motif; other site 649831008446 Walker B; other site 649831008447 D-loop; other site 649831008448 H-loop/switch region; other site 649831008449 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 649831008450 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 649831008451 Walker A/P-loop; other site 649831008452 ATP binding site [chemical binding]; other site 649831008453 Q-loop/lid; other site 649831008454 ABC transporter signature motif; other site 649831008455 Walker B; other site 649831008456 D-loop; other site 649831008457 H-loop/switch region; other site 649831008458 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 649831008459 Cellulose binding domain; Region: CBM_2; pfam00553 649831008460 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 649831008461 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 649831008462 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831008463 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 649831008464 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831008465 NAD(P) binding site [chemical binding]; other site 649831008466 active site 649831008467 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 649831008468 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 649831008469 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 649831008470 Transcriptional regulator [Transcription]; Region: IclR; COG1414 649831008471 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 649831008472 Bacterial transcriptional regulator; Region: IclR; pfam01614 649831008473 dihydroxy-acid dehydratase; Validated; Region: PRK06131 649831008474 short chain dehydrogenase; Provisional; Region: PRK06138 649831008475 classical (c) SDRs; Region: SDR_c; cd05233 649831008476 NAD(P) binding site [chemical binding]; other site 649831008477 active site 649831008478 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 649831008479 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 649831008480 Bulb-type mannose-specific lectin; Region: B_lectin; smart00108 649831008481 Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028 649831008482 dimerization interface [polypeptide binding]; other site 649831008483 mannose binding site [chemical binding]; other site 649831008484 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 649831008485 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 649831008486 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 649831008487 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831008488 NAD(P) binding site [chemical binding]; other site 649831008489 active site 649831008490 3-oxo-5-alpha-steroid 4-dehydrogenase; Region: Steroid_dh; cl17474 649831008491 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 649831008492 active site 649831008493 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 649831008494 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 649831008495 active site 649831008496 Transcriptional regulator [Transcription]; Region: IclR; COG1414 649831008497 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 649831008498 Bacterial transcriptional regulator; Region: IclR; pfam01614 649831008499 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 649831008500 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 649831008501 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 649831008502 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831008503 Major Facilitator Superfamily; Region: MFS_1; pfam07690 649831008504 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831008505 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831008506 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 649831008507 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 649831008508 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 649831008509 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 649831008510 salt bridge; other site 649831008511 non-specific DNA binding site [nucleotide binding]; other site 649831008512 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 649831008513 sequence-specific DNA binding site [nucleotide binding]; other site 649831008514 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 649831008515 Catalytic domain of Protein Kinases; Region: PKc; cd00180 649831008516 active site 649831008517 ATP binding site [chemical binding]; other site 649831008518 substrate binding site [chemical binding]; other site 649831008519 activation loop (A-loop); other site 649831008520 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 649831008521 Ferredoxin [Energy production and conversion]; Region: COG1146 649831008522 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 649831008523 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 649831008524 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 649831008525 ATP-grasp domain; Region: ATP-grasp_4; cl17255 649831008526 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 649831008527 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 649831008528 carboxyltransferase (CT) interaction site; other site 649831008529 biotinylation site [posttranslational modification]; other site 649831008530 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 649831008531 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 649831008532 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 649831008533 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 649831008534 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 649831008535 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 649831008536 classical (c) SDRs; Region: SDR_c; cd05233 649831008537 NAD(P) binding site [chemical binding]; other site 649831008538 active site 649831008539 Domain of unknown function (DUF1772); Region: DUF1772; pfam08592 649831008540 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 649831008541 N-terminal aromatase/cyclase domain of the multifunctional protein tetracenomycin (TcmN) and related domains; Region: TcmN_ARO-CYC_like; cd08860 649831008542 putative hydrophobic ligand binding site [chemical binding]; other site 649831008543 active site 649831008544 catalytic residues_2 [active] 649831008545 catalytic residues_1 [active] 649831008546 Chain-length factor (CLF) is a factor required for polyketide chain initiation of aromatic antibiotic-producing polyketide synthases (PKSs) of filamentous bacteria. CLFs have been shown to have decarboxylase activity towards malonyl-acyl carrier protein; Region: CLF; cd00832 649831008547 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 649831008548 active site 649831008549 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 649831008550 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 649831008551 dimer interface [polypeptide binding]; other site 649831008552 active site 649831008553 Cupin domain; Region: Cupin_2; pfam07883 649831008554 Polyketide synthesis cyclase; Region: Cyclase_polyket; pfam04673 649831008555 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 649831008556 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831008557 NAD(P) binding site [chemical binding]; other site 649831008558 active site 649831008559 SchA/CurD like domain; Region: SchA_CurD; pfam04486 649831008560 Domain of unknown function (DUF1772); Region: DUF1772; cl12097 649831008561 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 649831008562 Cytochrome P450; Region: p450; cl12078 649831008563 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 649831008564 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 649831008565 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 649831008566 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 649831008567 Cytochrome P450; Region: p450; cl12078 649831008568 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 649831008569 ABC-2 type transporter; Region: ABC2_membrane; cl17235 649831008570 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649831008571 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 649831008572 Walker A/P-loop; other site 649831008573 ATP binding site [chemical binding]; other site 649831008574 Q-loop/lid; other site 649831008575 ABC transporter signature motif; other site 649831008576 Walker B; other site 649831008577 D-loop; other site 649831008578 H-loop/switch region; other site 649831008579 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 649831008580 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 649831008581 dimer interface [polypeptide binding]; other site 649831008582 active site 649831008583 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 649831008584 Ligand Binding Site [chemical binding]; other site 649831008585 Molecular Tunnel; other site 649831008586 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 649831008587 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 649831008588 homodimer interface [polypeptide binding]; other site 649831008589 active site 649831008590 TDP-binding site; other site 649831008591 acceptor substrate-binding pocket; other site 649831008592 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 649831008593 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 649831008594 inhibitor-cofactor binding pocket; inhibition site 649831008595 pyridoxal 5'-phosphate binding site [chemical binding]; other site 649831008596 catalytic residue [active] 649831008597 O-methyltransferase; Region: Methyltransf_2; pfam00891 649831008598 WxcM-like, C-terminal; Region: FdtA; pfam05523 649831008599 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 649831008600 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 649831008601 homodimer interface [polypeptide binding]; other site 649831008602 active site 649831008603 TDP-binding site; other site 649831008604 acceptor substrate-binding pocket; other site 649831008605 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 649831008606 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649831008607 S-adenosylmethionine binding site [chemical binding]; other site 649831008608 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 649831008609 Cytochrome P450; Region: p450; cl12078 649831008610 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 649831008611 classical (c) SDRs; Region: SDR_c; cd05233 649831008612 NAD(P) binding site [chemical binding]; other site 649831008613 active site 649831008614 SchA/CurD like domain; Region: SchA_CurD; pfam04486 649831008615 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 649831008616 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 649831008617 O-methyltransferase; Region: Methyltransf_2; pfam00891 649831008618 Methyltransferase domain; Region: Methyltransf_23; pfam13489 649831008619 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 649831008620 ferredoxin-NADP+ reductase; Region: PLN02852 649831008621 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831008622 putative substrate translocation pore; other site 649831008623 POT family; Region: PTR2; cl17359 649831008624 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 649831008625 DNA binding site [nucleotide binding] 649831008626 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 649831008627 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 649831008628 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 649831008629 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 649831008630 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 649831008631 NAD binding site [chemical binding]; other site 649831008632 substrate binding site [chemical binding]; other site 649831008633 homodimer interface [polypeptide binding]; other site 649831008634 active site 649831008635 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649831008636 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831008637 active site 649831008638 phosphorylation site [posttranslational modification] 649831008639 intermolecular recognition site; other site 649831008640 dimerization interface [polypeptide binding]; other site 649831008641 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649831008642 DNA binding residues [nucleotide binding] 649831008643 dimerization interface [polypeptide binding]; other site 649831008644 Histidine kinase; Region: HisKA_3; pfam07730 649831008645 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 649831008646 ATP binding site [chemical binding]; other site 649831008647 Mg2+ binding site [ion binding]; other site 649831008648 G-X-G motif; other site 649831008649 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 649831008650 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 649831008651 Walker A/P-loop; other site 649831008652 ATP binding site [chemical binding]; other site 649831008653 Q-loop/lid; other site 649831008654 ABC transporter signature motif; other site 649831008655 Walker B; other site 649831008656 D-loop; other site 649831008657 H-loop/switch region; other site 649831008658 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 649831008659 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 649831008660 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 649831008661 FtsX-like permease family; Region: FtsX; pfam02687 649831008662 G1P_TT_long represents the long form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_long; cd04189 649831008663 glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208 649831008664 substrate binding site; other site 649831008665 metal-binding site 649831008666 Oligomer interface; other site 649831008667 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 649831008668 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 649831008669 nudix motif; other site 649831008670 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 649831008671 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 649831008672 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 649831008673 Soluble P-type ATPase [General function prediction only]; Region: COG4087 649831008674 K+-transporting ATPase, c chain; Region: KdpC; cl00944 649831008675 K+-transporting ATPase, c chain; Region: KdpC; cl00944 649831008676 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 649831008677 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 649831008678 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 649831008679 Ligand Binding Site [chemical binding]; other site 649831008680 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 649831008681 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 649831008682 dimer interface [polypeptide binding]; other site 649831008683 phosphorylation site [posttranslational modification] 649831008684 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831008685 ATP binding site [chemical binding]; other site 649831008686 Mg2+ binding site [ion binding]; other site 649831008687 G-X-G motif; other site 649831008688 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 649831008689 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831008690 active site 649831008691 phosphorylation site [posttranslational modification] 649831008692 intermolecular recognition site; other site 649831008693 dimerization interface [polypeptide binding]; other site 649831008694 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 649831008695 DNA binding site [nucleotide binding] 649831008696 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 649831008697 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 649831008698 active site 649831008699 catalytic tetrad [active] 649831008700 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 649831008701 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831008702 NAD(P) binding site [chemical binding]; other site 649831008703 active site 649831008704 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 649831008705 nudix motif; other site 649831008706 SnoaL-like domain; Region: SnoaL_4; pfam13577 649831008707 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 649831008708 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 649831008709 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 649831008710 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 649831008711 acyl-activating enzyme (AAE) consensus motif; other site 649831008712 AMP binding site [chemical binding]; other site 649831008713 active site 649831008714 CoA binding site [chemical binding]; other site 649831008715 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 649831008716 putative active site [active] 649831008717 putative catalytic site [active] 649831008718 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 649831008719 active site 649831008720 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 649831008721 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831008722 NAD(P) binding site [chemical binding]; other site 649831008723 active site 649831008724 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 649831008725 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 649831008726 TM-ABC transporter signature motif; other site 649831008727 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 649831008728 TM-ABC transporter signature motif; other site 649831008729 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 649831008730 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 649831008731 Walker A/P-loop; other site 649831008732 ATP binding site [chemical binding]; other site 649831008733 Q-loop/lid; other site 649831008734 ABC transporter signature motif; other site 649831008735 Walker B; other site 649831008736 D-loop; other site 649831008737 H-loop/switch region; other site 649831008738 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 649831008739 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 649831008740 Walker A/P-loop; other site 649831008741 ATP binding site [chemical binding]; other site 649831008742 Q-loop/lid; other site 649831008743 ABC transporter signature motif; other site 649831008744 Walker B; other site 649831008745 D-loop; other site 649831008746 H-loop/switch region; other site 649831008747 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 649831008748 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 649831008749 PaaX-like protein; Region: PaaX; pfam07848 649831008750 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 649831008751 Protein of unknown function (DUF1348); Region: DUF1348; pfam07080 649831008752 SnoaL-like domain; Region: SnoaL_2; pfam12680 649831008753 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 649831008754 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831008755 Predicted transcriptional regulators [Transcription]; Region: COG1695 649831008756 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 649831008757 TM1410 hypothetical-related protein; Region: DUF297; pfam03537 649831008758 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 649831008759 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 649831008760 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 649831008761 DNA binding residues [nucleotide binding] 649831008762 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 649831008763 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 649831008764 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 649831008765 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 649831008766 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 649831008767 Cellulose binding domain; Region: CBM_2; pfam00553 649831008768 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 649831008769 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 649831008770 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 649831008771 putative sugar binding sites [chemical binding]; other site 649831008772 Q-X-W motif; other site 649831008773 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 649831008774 Cellulose binding domain; Region: CBM_2; pfam00553 649831008775 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 649831008776 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 649831008777 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 649831008778 Interdomain contacts; other site 649831008779 Cytokine receptor motif; other site 649831008780 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 649831008781 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 649831008782 PaaX-like protein; Region: PaaX; pfam07848 649831008783 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 649831008784 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 649831008785 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 649831008786 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 649831008787 Cellulose binding domain; Region: CBM_2; pfam00553 649831008788 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 649831008789 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 649831008790 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649831008791 dimer interface [polypeptide binding]; other site 649831008792 conserved gate region; other site 649831008793 putative PBP binding loops; other site 649831008794 ABC-ATPase subunit interface; other site 649831008795 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 649831008796 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649831008797 dimer interface [polypeptide binding]; other site 649831008798 conserved gate region; other site 649831008799 putative PBP binding loops; other site 649831008800 ABC-ATPase subunit interface; other site 649831008801 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 649831008802 active site 649831008803 Zn binding site [ion binding]; other site 649831008804 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 649831008805 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 649831008806 Methyltransferase domain; Region: Methyltransf_23; pfam13489 649831008807 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 649831008808 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 649831008809 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 649831008810 NAD binding site [chemical binding]; other site 649831008811 substrate binding site [chemical binding]; other site 649831008812 homodimer interface [polypeptide binding]; other site 649831008813 active site 649831008814 SCP-2 sterol transfer family; Region: SCP2; pfam02036 649831008815 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 649831008816 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 649831008817 acyl-activating enzyme (AAE) consensus motif; other site 649831008818 active site 649831008819 AMP binding site [chemical binding]; other site 649831008820 substrate binding site [chemical binding]; other site 649831008821 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 649831008822 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831008823 active site 649831008824 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 649831008825 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 649831008826 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831008827 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 649831008828 NAD(P) binding site [chemical binding]; other site 649831008829 active site 649831008830 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831008831 conserved hypothetical protein; Region: TIGR02246 649831008832 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 649831008833 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 649831008834 choline dehydrogenase; Validated; Region: PRK02106 649831008835 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 649831008836 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 649831008837 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 649831008838 active site 649831008839 Epoxide hydrolase N terminus; Region: EHN; pfam06441 649831008840 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 649831008841 dimer interface [polypeptide binding]; other site 649831008842 catalytic triad [active] 649831008843 peroxidatic and resolving cysteines [active] 649831008844 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 649831008845 hypothetical protein; Provisional; Region: PRK06185 649831008846 PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398 649831008847 active site 649831008848 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 649831008849 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 649831008850 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 649831008851 Protein of unknown function (DUF1702); Region: DUF1702; pfam08012 649831008852 TIGR03084 family protein; Region: TIGR03084 649831008853 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 649831008854 Wyosine base formation; Region: Wyosine_form; pfam08608 649831008855 Protein of unknown function (DUF1702); Region: DUF1702; pfam08012 649831008856 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831008857 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 649831008858 active site 649831008859 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 649831008860 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 649831008861 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 649831008862 putative NADP binding site [chemical binding]; other site 649831008863 active site 649831008864 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 649831008865 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 649831008866 active site 649831008867 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 649831008868 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 649831008869 Cytochrome P450; Region: p450; cl12078 649831008870 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 649831008871 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 649831008872 DNA binding residues [nucleotide binding] 649831008873 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 649831008874 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 649831008875 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 649831008876 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 649831008877 homodimer interface [polypeptide binding]; other site 649831008878 active site 649831008879 TDP-binding site; other site 649831008880 acceptor substrate-binding pocket; other site 649831008881 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 649831008882 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 649831008883 homodimer interface [polypeptide binding]; other site 649831008884 active site 649831008885 TDP-binding site; other site 649831008886 acceptor substrate-binding pocket; other site 649831008887 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 649831008888 Beta-lactamase; Region: Beta-lactamase; pfam00144 649831008889 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 649831008890 Cytochrome P450; Region: p450; cl12078 649831008891 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 649831008892 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 649831008893 active site 649831008894 TDP-binding site; other site 649831008895 acceptor substrate-binding pocket; other site 649831008896 homodimer interface [polypeptide binding]; other site 649831008897 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 649831008898 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 649831008899 Cytochrome P450; Region: p450; cl12078 649831008900 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 649831008901 Protein of unknown function (DUF1271); Region: DUF1271; pfam06902 649831008902 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 649831008903 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 649831008904 substrate binding site; other site 649831008905 tetramer interface; other site 649831008906 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 649831008907 active site 649831008908 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 649831008909 dimer interface [polypeptide binding]; other site 649831008910 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 649831008911 Ligand Binding Site [chemical binding]; other site 649831008912 Molecular Tunnel; other site 649831008913 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 649831008914 RibD C-terminal domain; Region: RibD_C; cl17279 649831008915 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 649831008916 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 649831008917 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 649831008918 YCII-related domain; Region: YCII; cl00999 649831008919 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 649831008920 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 649831008921 CopC domain; Region: CopC; pfam04234 649831008922 Family description; Region: VCBS; pfam13517 649831008923 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 649831008924 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 649831008925 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 649831008926 FMN binding site [chemical binding]; other site 649831008927 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 649831008928 dimer interface [polypeptide binding]; other site 649831008929 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1, 4-benzoquinol methylase [Coenzyme metabolism]; Region: UbiG; COG2227 649831008930 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649831008931 S-adenosylmethionine binding site [chemical binding]; other site 649831008932 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 649831008933 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 649831008934 active site 649831008935 Glycosyl hydrolase family 43; Region: GH43_6; cd08985 649831008936 active site 649831008937 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 649831008938 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 649831008939 putative sugar binding sites [chemical binding]; other site 649831008940 Q-X-W motif; other site 649831008941 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 649831008942 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 649831008943 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 649831008944 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 649831008945 Predicted transcriptional regulators [Transcription]; Region: COG1733 649831008946 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 649831008947 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 649831008948 HAMP domain; Region: HAMP; pfam00672 649831008949 dimerization interface [polypeptide binding]; other site 649831008950 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 649831008951 dimer interface [polypeptide binding]; other site 649831008952 phosphorylation site [posttranslational modification] 649831008953 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831008954 ATP binding site [chemical binding]; other site 649831008955 Mg2+ binding site [ion binding]; other site 649831008956 G-X-G motif; other site 649831008957 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831008958 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 649831008959 active site 649831008960 phosphorylation site [posttranslational modification] 649831008961 intermolecular recognition site; other site 649831008962 dimerization interface [polypeptide binding]; other site 649831008963 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 649831008964 DNA binding site [nucleotide binding] 649831008965 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 649831008966 cleavage site 649831008967 active site 649831008968 substrate binding sites [chemical binding]; other site 649831008969 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 649831008970 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 649831008971 nucleotide binding site [chemical binding]; other site 649831008972 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 649831008973 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831008974 active site 649831008975 phosphorylation site [posttranslational modification] 649831008976 intermolecular recognition site; other site 649831008977 dimerization interface [polypeptide binding]; other site 649831008978 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 649831008979 putative binding surface; other site 649831008980 active site 649831008981 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 649831008982 conserved cys residue [active] 649831008983 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 649831008984 Beta-galactosidase, domain 2; Region: BetaGal_dom2; smart01029 649831008985 Beta-galactosidase, domain 2; Region: BetaGal_dom2; smart01029 649831008986 Beta-galactosidase, domain 3; Region: BetaGal_dom3; pfam13363 649831008987 Beta-galactosidase jelly roll domain; Region: BetaGal_dom4_5; pfam13364 649831008988 Beta-galactosidase jelly roll domain; Region: BetaGal_dom4_5; pfam13364 649831008989 NPCBM/NEW2 domain; Region: NPCBM; pfam08305 649831008990 Uncharacterized conserved protein (DUF2267); Region: DUF2267; cl02314 649831008991 Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457 649831008992 CBD_II domain; Region: CBD_II; smart00637 649831008993 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831008994 TIGR01777 family protein; Region: yfcH 649831008995 NAD(P) binding site [chemical binding]; other site 649831008996 active site 649831008997 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 649831008998 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 649831008999 putative ligand binding site [chemical binding]; other site 649831009000 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 649831009001 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 649831009002 Walker A/P-loop; other site 649831009003 ATP binding site [chemical binding]; other site 649831009004 Q-loop/lid; other site 649831009005 ABC transporter signature motif; other site 649831009006 Walker B; other site 649831009007 D-loop; other site 649831009008 H-loop/switch region; other site 649831009009 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 649831009010 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 649831009011 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 649831009012 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 649831009013 TM-ABC transporter signature motif; other site 649831009014 alpha-galactosidase; Region: PLN02808; cl17638 649831009015 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 649831009016 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 649831009017 putative sugar binding sites [chemical binding]; other site 649831009018 Q-X-W motif; other site 649831009019 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 649831009020 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 649831009021 Cellulose binding domain; Region: CBM_2; pfam00553 649831009022 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 649831009023 Putative esterase; Region: Esterase; pfam00756 649831009024 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 649831009025 active site 649831009026 catalytic triad [active] 649831009027 oxyanion hole [active] 649831009028 Methyltransferase domain; Region: Methyltransf_23; pfam13489 649831009029 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649831009030 S-adenosylmethionine binding site [chemical binding]; other site 649831009031 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 649831009032 Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487 649831009033 active site 649831009034 catalytic triad [active] 649831009035 Cellulose binding domain; Region: CBM_2; pfam00553 649831009036 Glycosyl hydrolase family 62; Region: Glyco_hydro_62; pfam03664 649831009037 active site 649831009038 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 649831009039 CBD_II domain; Region: CBD_II; smart00637 649831009040 Glycosyl hydrolase family 59; Region: Glyco_hydro_59; pfam02057 649831009041 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 649831009042 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 649831009043 putative sugar binding sites [chemical binding]; other site 649831009044 Q-X-W motif; other site 649831009045 Cellulose binding domain; Region: CBM_2; pfam00553 649831009046 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 649831009047 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 649831009048 active site 649831009049 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 649831009050 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 649831009051 Cellulose binding domain; Region: CBM_2; pfam00553 649831009052 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 649831009053 putative metal binding site [ion binding]; other site 649831009054 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 649831009055 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 649831009056 active site 649831009057 catalytic site [active] 649831009058 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 649831009059 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 649831009060 putative sugar binding sites [chemical binding]; other site 649831009061 Q-X-W motif; other site 649831009062 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 649831009063 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 649831009064 putative sugar binding sites [chemical binding]; other site 649831009065 Q-X-W motif; other site 649831009066 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 649831009067 Transcriptional regulators [Transcription]; Region: MarR; COG1846 649831009068 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 649831009069 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 649831009070 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 649831009071 active site 649831009072 catalytic triad [active] 649831009073 oxyanion hole [active] 649831009074 Glyoxal oxidase N-terminus; Region: Glyoxal_oxid_N; pfam07250 649831009075 Kelch motif; Region: Kelch_6; pfam13964 649831009076 C-terminal Early set domain associated with the catalytic domain of galactose oxidase; Region: E_set_GO_C; cd02851 649831009077 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 649831009078 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 649831009079 putative sugar binding sites [chemical binding]; other site 649831009080 Q-X-W motif; other site 649831009081 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 649831009082 SGNH_hydrolase subfamily, similar to Ruminococcus flavefaciens XynB. Most likely a secreted hydrolase with xylanase activity. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from...; Region: XynB_like; cd01833 649831009083 active site 649831009084 catalytic triad [active] 649831009085 oxyanion hole [active] 649831009086 CBD_II domain; Region: CBD_II; smart00637 649831009087 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 649831009088 classical (c) SDRs; Region: SDR_c; cd05233 649831009089 NAD(P) binding site [chemical binding]; other site 649831009090 active site 649831009091 Predicted transcriptional regulator [Transcription]; Region: COG1959 649831009092 Transcriptional regulator; Region: Rrf2; pfam02082 649831009093 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 649831009094 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 649831009095 NodB motif; other site 649831009096 active site 649831009097 catalytic site [active] 649831009098 metal binding site [ion binding]; metal-binding site 649831009099 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 649831009100 catalytic residues [active] 649831009101 dimer interface [polypeptide binding]; other site 649831009102 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 649831009103 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 649831009104 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 649831009105 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 649831009106 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831009107 Streptomyces extracellular neutral proteinase (M7) family; Region: Peptidase_M7; pfam02031 649831009108 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 649831009109 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 649831009110 NAD binding site [chemical binding]; other site 649831009111 catalytic Zn binding site [ion binding]; other site 649831009112 structural Zn binding site [ion binding]; other site 649831009113 AAA ATPase domain; Region: AAA_16; pfam13191 649831009114 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649831009115 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649831009116 DNA binding residues [nucleotide binding] 649831009117 dimerization interface [polypeptide binding]; other site 649831009118 Cupin domain; Region: Cupin_2; cl17218 649831009119 short chain dehydrogenase; Provisional; Region: PRK06523 649831009120 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831009121 NAD(P) binding site [chemical binding]; other site 649831009122 active site 649831009123 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 649831009124 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 649831009125 AAA ATPase domain; Region: AAA_16; pfam13191 649831009126 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649831009127 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649831009128 DNA binding residues [nucleotide binding] 649831009129 dimerization interface [polypeptide binding]; other site 649831009130 Domain of unknown function (DUF3291); Region: DUF3291; pfam11695 649831009131 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 649831009132 Cytochrome P450; Region: p450; cl12078 649831009133 Fungalysin metallopeptidase (M36); Region: Peptidase_M36; pfam02128 649831009134 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 649831009135 Zn binding site [ion binding]; other site 649831009136 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 649831009137 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 649831009138 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 649831009139 Glycosyl hydrolase family 43; Region: GH43_ABN_2; cd08999 649831009140 putative substrate binding site [chemical binding]; other site 649831009141 active site 649831009142 Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081 649831009143 Ca binding site [ion binding]; other site 649831009144 Domain of unknown function (DUF305); Region: DUF305; pfam03713 649831009145 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 649831009146 pyridoxamine kinase; Validated; Region: PRK05756 649831009147 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 649831009148 dimer interface [polypeptide binding]; other site 649831009149 pyridoxal binding site [chemical binding]; other site 649831009150 ATP binding site [chemical binding]; other site 649831009151 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 649831009152 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 649831009153 metal binding site [ion binding]; metal-binding site 649831009154 active site 649831009155 I-site; other site 649831009156 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 649831009157 Predicted permease; Region: DUF318; cl17795 649831009158 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 649831009159 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 649831009160 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 649831009161 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 649831009162 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 649831009163 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 649831009164 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 649831009165 Walker A/P-loop; other site 649831009166 ATP binding site [chemical binding]; other site 649831009167 Q-loop/lid; other site 649831009168 ABC transporter signature motif; other site 649831009169 Walker B; other site 649831009170 D-loop; other site 649831009171 H-loop/switch region; other site 649831009172 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 649831009173 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 649831009174 Beta-lactamase; Region: Beta-lactamase; pfam00144 649831009175 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 649831009176 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 649831009177 Walker A/P-loop; other site 649831009178 ATP binding site [chemical binding]; other site 649831009179 Q-loop/lid; other site 649831009180 ABC transporter signature motif; other site 649831009181 Walker B; other site 649831009182 D-loop; other site 649831009183 H-loop/switch region; other site 649831009184 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 649831009185 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 649831009186 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 649831009187 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 649831009188 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 649831009189 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 649831009190 Beta-lactamase; Region: Beta-lactamase; pfam00144 649831009191 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 649831009192 Peptidase family M20/M25/M40; Region: Peptidase_M20; pfam01546 649831009193 metal binding site [ion binding]; metal-binding site 649831009194 dimer interface [polypeptide binding]; other site 649831009195 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 649831009196 Coenzyme A binding pocket [chemical binding]; other site 649831009197 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 649831009198 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 649831009199 active site 649831009200 octamer interface [polypeptide binding]; other site 649831009201 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831009202 Major Facilitator Superfamily; Region: MFS_1; pfam07690 649831009203 putative substrate translocation pore; other site 649831009204 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831009205 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 649831009206 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831009207 Predicted transcriptional regulators [Transcription]; Region: COG1695 649831009208 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 649831009209 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 649831009210 FOG: WD40 repeat [General function prediction only]; Region: COG2319 649831009211 structural tetrad; other site 649831009212 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 649831009213 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831009214 NAD(P) binding site [chemical binding]; other site 649831009215 active site 649831009216 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 649831009217 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 649831009218 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 649831009219 Interdomain contacts; other site 649831009220 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 649831009221 Interdomain contacts; other site 649831009222 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 649831009223 Interdomain contacts; other site 649831009224 Cytokine receptor motif; other site 649831009225 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 649831009226 Interdomain contacts; other site 649831009227 Cytokine receptor motif; other site 649831009228 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 649831009229 Interdomain contacts; other site 649831009230 Cytokine receptor motif; other site 649831009231 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 649831009232 Interdomain contacts; other site 649831009233 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 649831009234 Interdomain contacts; other site 649831009235 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 649831009236 Interdomain contacts; other site 649831009237 Cytokine receptor motif; other site 649831009238 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 649831009239 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 649831009240 Interdomain contacts; other site 649831009241 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 649831009242 Interdomain contacts; other site 649831009243 Cytokine receptor motif; other site 649831009244 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 649831009245 Interdomain contacts; other site 649831009246 Cytokine receptor motif; other site 649831009247 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 649831009248 Interdomain contacts; other site 649831009249 Cytokine receptor motif; other site 649831009250 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 649831009251 Interdomain contacts; other site 649831009252 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 649831009253 Interdomain contacts; other site 649831009254 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 649831009255 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 649831009256 Interdomain contacts; other site 649831009257 Cytokine receptor motif; other site 649831009258 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 649831009259 Interdomain contacts; other site 649831009260 Cytokine receptor motif; other site 649831009261 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831009262 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 649831009263 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831009264 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 649831009265 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 649831009266 putative NAD(P) binding site [chemical binding]; other site 649831009267 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 649831009268 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 649831009269 conserved cys residue [active] 649831009270 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 649831009271 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 649831009272 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 649831009273 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 649831009274 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 649831009275 dimerization interface [polypeptide binding]; other site 649831009276 substrate binding pocket [chemical binding]; other site 649831009277 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 649831009278 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 649831009279 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 649831009280 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 649831009281 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 649831009282 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 649831009283 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 649831009284 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 649831009285 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 649831009286 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 649831009287 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 649831009288 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 649831009289 anti sigma factor interaction site; other site 649831009290 regulatory phosphorylation site [posttranslational modification]; other site 649831009291 Uncharacterized conserved protein [Function unknown]; Region: COG3349 649831009292 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 649831009293 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 649831009294 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 649831009295 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 649831009296 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831009297 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 649831009298 Beta-lactamase; Region: Beta-lactamase; pfam00144 649831009299 Response regulator receiver domain; Region: Response_reg; pfam00072 649831009300 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831009301 active site 649831009302 phosphorylation site [posttranslational modification] 649831009303 intermolecular recognition site; other site 649831009304 dimerization interface [polypeptide binding]; other site 649831009305 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 649831009306 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 649831009307 dimerization interface [polypeptide binding]; other site 649831009308 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 649831009309 dimer interface [polypeptide binding]; other site 649831009310 phosphorylation site [posttranslational modification] 649831009311 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831009312 ATP binding site [chemical binding]; other site 649831009313 Mg2+ binding site [ion binding]; other site 649831009314 G-X-G motif; other site 649831009315 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 649831009316 Transcriptional regulator [Transcription]; Region: LysR; COG0583 649831009317 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 649831009318 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 649831009319 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831009320 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831009321 NAD(P) binding site [chemical binding]; other site 649831009322 active site 649831009323 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 649831009324 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 649831009325 TAP-like protein; Region: Abhydrolase_4; pfam08386 649831009326 Cupin domain; Region: Cupin_2; pfam07883 649831009327 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 649831009328 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 649831009329 non-specific DNA binding site [nucleotide binding]; other site 649831009330 salt bridge; other site 649831009331 sequence-specific DNA binding site [nucleotide binding]; other site 649831009332 AAA ATPase domain; Region: AAA_16; pfam13191 649831009333 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 649831009334 TPR motif; other site 649831009335 Tetratricopeptide repeat; Region: TPR_12; pfam13424 649831009336 binding surface 649831009337 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 649831009338 binding surface 649831009339 Tetratricopeptide repeat; Region: TPR_12; pfam13424 649831009340 TPR motif; other site 649831009341 Tetratricopeptide repeat; Region: TPR_12; pfam13424 649831009342 Cellulose binding domain; Region: CBM_2; pfam00553 649831009343 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 649831009344 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 649831009345 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 649831009346 dimer interface [polypeptide binding]; other site 649831009347 phosphorylation site [posttranslational modification] 649831009348 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831009349 ATP binding site [chemical binding]; other site 649831009350 Mg2+ binding site [ion binding]; other site 649831009351 G-X-G motif; other site 649831009352 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 649831009353 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831009354 active site 649831009355 phosphorylation site [posttranslational modification] 649831009356 intermolecular recognition site; other site 649831009357 dimerization interface [polypeptide binding]; other site 649831009358 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 649831009359 DNA binding site [nucleotide binding] 649831009360 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 649831009361 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 649831009362 putative NAD(P) binding site [chemical binding]; other site 649831009363 putative substrate binding site [chemical binding]; other site 649831009364 catalytic Zn binding site [ion binding]; other site 649831009365 structural Zn binding site [ion binding]; other site 649831009366 dimer interface [polypeptide binding]; other site 649831009367 Bacterial Ig-like domain; Region: Big_5; pfam13205 649831009368 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 649831009369 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 649831009370 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 649831009371 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 649831009372 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 649831009373 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 649831009374 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 649831009375 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 649831009376 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 649831009377 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 649831009378 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 649831009379 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 649831009380 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 649831009381 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 649831009382 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 649831009383 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 649831009384 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649831009385 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649831009386 DNA binding residues [nucleotide binding] 649831009387 dimerization interface [polypeptide binding]; other site 649831009388 AAA ATPase domain; Region: AAA_16; pfam13191 649831009389 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649831009390 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649831009391 DNA binding residues [nucleotide binding] 649831009392 dimerization interface [polypeptide binding]; other site 649831009393 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 649831009394 Cytochrome P450; Region: p450; cl12078 649831009395 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 649831009396 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 649831009397 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 649831009398 Walker A/P-loop; other site 649831009399 ATP binding site [chemical binding]; other site 649831009400 Q-loop/lid; other site 649831009401 ABC transporter signature motif; other site 649831009402 Walker B; other site 649831009403 D-loop; other site 649831009404 H-loop/switch region; other site 649831009405 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 649831009406 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 649831009407 TM-ABC transporter signature motif; other site 649831009408 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 649831009409 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 649831009410 TM-ABC transporter signature motif; other site 649831009411 PemK-like protein; Region: PemK; cl00995 649831009412 hypothetical protein; Provisional; Region: PRK08244 649831009413 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 649831009414 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 649831009415 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 649831009416 Right handed beta helix region; Region: Beta_helix; pfam13229 649831009417 Predicted esterase [General function prediction only]; Region: COG0400 649831009418 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 649831009419 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 649831009420 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831009421 Transcriptional regulators [Transcription]; Region: FadR; COG2186 649831009422 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 649831009423 DNA-binding site [nucleotide binding]; DNA binding site 649831009424 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 649831009425 Coenzyme A binding pocket [chemical binding]; other site 649831009426 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 649831009427 CoA binding domain; Region: CoA_binding_2; pfam13380 649831009428 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 649831009429 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 649831009430 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cd00321 649831009431 Moco binding site; other site 649831009432 metal coordination site [ion binding]; other site 649831009433 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 649831009434 Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; cl17492 649831009435 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 649831009436 active site 649831009437 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 649831009438 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831009439 NAD(P) binding site [chemical binding]; other site 649831009440 active site 649831009441 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 649831009442 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831009443 active site 649831009444 phosphorylation site [posttranslational modification] 649831009445 intermolecular recognition site; other site 649831009446 dimerization interface [polypeptide binding]; other site 649831009447 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 649831009448 DNA binding site [nucleotide binding] 649831009449 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 649831009450 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 649831009451 dimer interface [polypeptide binding]; other site 649831009452 phosphorylation site [posttranslational modification] 649831009453 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831009454 ATP binding site [chemical binding]; other site 649831009455 Mg2+ binding site [ion binding]; other site 649831009456 G-X-G motif; other site 649831009457 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 649831009458 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 649831009459 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 649831009460 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 649831009461 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 649831009462 putative DNA binding site [nucleotide binding]; other site 649831009463 dimerization interface [polypeptide binding]; other site 649831009464 Transcriptional regulators [Transcription]; Region: MarR; COG1846 649831009465 putative Zn2+ binding site [ion binding]; other site 649831009466 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 649831009467 catalytic core [active] 649831009468 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 649831009469 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 649831009470 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 649831009471 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 649831009472 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 649831009473 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 649831009474 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 649831009475 NAD binding site [chemical binding]; other site 649831009476 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 649831009477 Ligand Binding Site [chemical binding]; other site 649831009478 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 649831009479 Ligand Binding Site [chemical binding]; other site 649831009480 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 649831009481 Ligand Binding Site [chemical binding]; other site 649831009482 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 649831009483 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 649831009484 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 649831009485 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 649831009486 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 649831009487 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649831009488 Q-loop/lid; other site 649831009489 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 649831009490 NodB motif; other site 649831009491 active site 649831009492 catalytic site [active] 649831009493 metal binding site [ion binding]; metal-binding site 649831009494 LGFP repeat; Region: LGFP; pfam08310 649831009495 LGFP repeat; Region: LGFP; pfam08310 649831009496 LGFP repeat; Region: LGFP; pfam08310 649831009497 hypothetical protein; Provisional; Region: PRK07877 649831009498 hypothetical protein; Provisional; Region: PRK07877 649831009499 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 649831009500 Ligand Binding Site [chemical binding]; other site 649831009501 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 649831009502 Ligand Binding Site [chemical binding]; other site 649831009503 FOG: CBS domain [General function prediction only]; Region: COG0517 649831009504 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 649831009505 FOG: CBS domain [General function prediction only]; Region: COG0517 649831009506 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 649831009507 Flavodoxin; Region: Flavodoxin_1; pfam00258 649831009508 FOG: CBS domain [General function prediction only]; Region: COG0517 649831009509 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 649831009510 BON domain; Region: BON; pfam04972 649831009511 Domain of unknown function (DUF1876); Region: DUF1876; pfam08962 649831009512 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 649831009513 Ligand Binding Site [chemical binding]; other site 649831009514 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 649831009515 Ligand Binding Site [chemical binding]; other site 649831009516 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 649831009517 Ligand Binding Site [chemical binding]; other site 649831009518 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 649831009519 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 649831009520 FMN binding site [chemical binding]; other site 649831009521 dimer interface [polypeptide binding]; other site 649831009522 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 649831009523 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 649831009524 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 649831009525 putative catalytic cysteine [active] 649831009526 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 649831009527 putative active site [active] 649831009528 metal binding site [ion binding]; metal-binding site 649831009529 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 649831009530 Ligand Binding Site [chemical binding]; other site 649831009531 hypothetical protein; Provisional; Region: PRK07877 649831009532 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 649831009533 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 649831009534 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 649831009535 FOG: CBS domain [General function prediction only]; Region: COG0517 649831009536 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 649831009537 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 649831009538 Ligand Binding Site [chemical binding]; other site 649831009539 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 649831009540 CheB methylesterase; Region: CheB_methylest; pfam01339 649831009541 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 649831009542 Ligand Binding Site [chemical binding]; other site 649831009543 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 649831009544 Ligand Binding Site [chemical binding]; other site 649831009545 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 649831009546 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 649831009547 Coenzyme A binding pocket [chemical binding]; other site 649831009548 CoA binding domain; Region: CoA_binding_2; pfam13380 649831009549 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 649831009550 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 649831009551 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 649831009552 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 649831009553 Ligand Binding Site [chemical binding]; other site 649831009554 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 649831009555 Ligand Binding Site [chemical binding]; other site 649831009556 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 649831009557 Ligand Binding Site [chemical binding]; other site 649831009558 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 649831009559 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 649831009560 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 649831009561 Ligand Binding Site [chemical binding]; other site 649831009562 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 649831009563 Ligand Binding Site [chemical binding]; other site 649831009564 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 649831009565 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 649831009566 putative dimer interface [polypeptide binding]; other site 649831009567 hypothetical protein; Provisional; Region: PRK07877 649831009568 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 649831009569 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 649831009570 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 649831009571 Histidine kinase; Region: HisKA_3; pfam07730 649831009572 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831009573 Mg2+ binding site [ion binding]; other site 649831009574 G-X-G motif; other site 649831009575 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649831009576 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831009577 active site 649831009578 phosphorylation site [posttranslational modification] 649831009579 intermolecular recognition site; other site 649831009580 dimerization interface [polypeptide binding]; other site 649831009581 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649831009582 DNA binding residues [nucleotide binding] 649831009583 dimerization interface [polypeptide binding]; other site 649831009584 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 649831009585 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 649831009586 FeS/SAM binding site; other site 649831009587 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 649831009588 Pyruvate formate lyase 1; Region: PFL1; cd01678 649831009589 coenzyme A binding site [chemical binding]; other site 649831009590 active site 649831009591 catalytic residues [active] 649831009592 glycine loop; other site 649831009593 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 649831009594 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 649831009595 NAD binding site [chemical binding]; other site 649831009596 substrate binding site [chemical binding]; other site 649831009597 catalytic Zn binding site [ion binding]; other site 649831009598 tetramer interface [polypeptide binding]; other site 649831009599 structural Zn binding site [ion binding]; other site 649831009600 pyruvate phosphate dikinase; Provisional; Region: PRK09279 649831009601 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 649831009602 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 649831009603 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 649831009604 FOG: CBS domain [General function prediction only]; Region: COG0517 649831009605 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 649831009606 BON domain; Region: BON; pfam04972 649831009607 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 649831009608 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 649831009609 ligand binding site [chemical binding]; other site 649831009610 flexible hinge region; other site 649831009611 putative phosphoketolase; Provisional; Region: PRK05261 649831009612 XFP N-terminal domain; Region: XFP_N; pfam09364 649831009613 XFP C-terminal domain; Region: XFP_C; pfam09363 649831009614 Nitroreductase family; Region: Nitroreductase; pfam00881 649831009615 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 649831009616 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 649831009617 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 649831009618 DoxX-like family; Region: DoxX_2; pfam13564 649831009619 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 649831009620 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 649831009621 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 649831009622 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 649831009623 Imelysin; Region: Peptidase_M75; pfam09375 649831009624 Iron permease FTR1 family; Region: FTR1; cl00475 649831009625 MarR family; Region: MarR_2; pfam12802 649831009626 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 649831009627 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 649831009628 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 649831009629 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831009630 NAD(P) binding site [chemical binding]; other site 649831009631 active site 649831009632 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 649831009633 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 649831009634 Cellulose binding domain; Region: CBM_2; cl17741 649831009635 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 649831009636 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 649831009637 putative DNA binding site [nucleotide binding]; other site 649831009638 putative Zn2+ binding site [ion binding]; other site 649831009639 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 649831009640 metal binding site 2 [ion binding]; metal-binding site 649831009641 putative DNA binding helix; other site 649831009642 metal binding site 1 [ion binding]; metal-binding site 649831009643 dimer interface [polypeptide binding]; other site 649831009644 structural Zn2+ binding site [ion binding]; other site 649831009645 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 649831009646 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 649831009647 dimer interface [polypeptide binding]; other site 649831009648 active site 649831009649 heme binding site [chemical binding]; other site 649831009650 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 649831009651 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 649831009652 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831009653 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 649831009654 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 649831009655 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831009656 putative substrate translocation pore; other site 649831009657 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831009658 NADH(P)-binding; Region: NAD_binding_10; pfam13460 649831009659 NAD(P) binding site [chemical binding]; other site 649831009660 active site 649831009661 Predicted transcriptional regulators [Transcription]; Region: COG1733 649831009662 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 649831009663 Zn_pept domain; Region: Zn_pept; smart00631 649831009664 active site 649831009665 Zn binding site [ion binding]; other site 649831009666 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 649831009667 classical (c) SDRs; Region: SDR_c; cd05233 649831009668 NAD(P) binding site [chemical binding]; other site 649831009669 active site 649831009670 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 649831009671 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831009672 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 649831009673 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 649831009674 active site 649831009675 catalytic tetrad [active] 649831009676 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 649831009677 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 649831009678 Zn binding site [ion binding]; other site 649831009679 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 649831009680 Bacterial transcriptional activator domain; Region: BTAD; smart01043 649831009681 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 649831009682 binding surface 649831009683 TPR motif; other site 649831009684 AAA ATPase domain; Region: AAA_16; pfam13191 649831009685 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649831009686 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649831009687 DNA binding residues [nucleotide binding] 649831009688 dimerization interface [polypeptide binding]; other site 649831009689 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 649831009690 binding surface 649831009691 TPR motif; other site 649831009692 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 649831009693 binding surface 649831009694 TPR motif; other site 649831009695 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 649831009696 TPR motif; other site 649831009697 binding surface 649831009698 TPR repeat; Region: TPR_11; pfam13414 649831009699 ERG2 and Sigma1 receptor like protein; Region: ERG2_Sigma1R; pfam04622 649831009700 Flavoprotein; Region: Flavoprotein; cl08021 649831009701 SprT homologues; Region: SprT; cl01182 649831009702 SprT-like family; Region: SprT-like; pfam10263 649831009703 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 649831009704 pyruvate dehydrogenase; Provisional; Region: PRK06546 649831009705 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 649831009706 PYR/PP interface [polypeptide binding]; other site 649831009707 tetramer interface [polypeptide binding]; other site 649831009708 dimer interface [polypeptide binding]; other site 649831009709 TPP binding site [chemical binding]; other site 649831009710 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 649831009711 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 649831009712 TPP-binding site [chemical binding]; other site 649831009713 exopolyphosphatase; Region: exo_poly_only; TIGR03706 649831009714 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 649831009715 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cd00164 649831009716 RNA binding site [nucleotide binding]; other site 649831009717 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cd00164 649831009718 RNA binding site [nucleotide binding]; other site 649831009719 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cd00164 649831009720 RNA binding site [nucleotide binding]; other site 649831009721 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 649831009722 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 649831009723 NB-ARC domain; Region: NB-ARC; pfam00931 649831009724 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 649831009725 TPR motif; other site 649831009726 Tetratricopeptide repeat; Region: TPR_12; pfam13424 649831009727 binding surface 649831009728 antimicrobial peptide system protein, SdpA family; Region: export_SdpA; TIGR04034 649831009729 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 649831009730 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 649831009731 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 649831009732 Transcriptional regulators [Transcription]; Region: PurR; COG1609 649831009733 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 649831009734 DNA binding site [nucleotide binding] 649831009735 domain linker motif; other site 649831009736 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 649831009737 dimerization interface [polypeptide binding]; other site 649831009738 ligand binding site [chemical binding]; other site 649831009739 PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398 649831009740 active site 649831009741 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 649831009742 active site 649831009743 catalytic triad [active] 649831009744 oxyanion hole [active] 649831009745 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 649831009746 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 649831009747 Alkaline phosphatase homologues; Region: alkPPc; smart00098 649831009748 active site 649831009749 dimer interface [polypeptide binding]; other site 649831009750 AAA domain; Region: AAA_11; pfam13086 649831009751 Part of AAA domain; Region: AAA_19; pfam13245 649831009752 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 649831009753 AAA domain; Region: AAA_12; pfam13087 649831009754 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 649831009755 putative active site [active] 649831009756 Alpha-L-arabinofuranosidase B, catalytic; Region: ArabFuran-catal; pfam09206 649831009757 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 649831009758 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 649831009759 putative sugar binding sites [chemical binding]; other site 649831009760 Q-X-W motif; other site 649831009761 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 649831009762 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 649831009763 putative sugar binding sites [chemical binding]; other site 649831009764 Q-X-W motif; other site 649831009765 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 649831009766 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 649831009767 Zn binding site [ion binding]; other site 649831009768 ferredoxin-NADP+ reductase; Region: PLN02852 649831009769 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 649831009770 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 649831009771 sugar binding site [chemical binding]; other site 649831009772 glycosyl hydrolase 64 family; Region: GH64-like; cd09214 649831009773 substrate binding pocket [chemical binding]; other site 649831009774 catalytic residues [active] 649831009775 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 649831009776 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 649831009777 MarR family; Region: MarR_2; pfam12802 649831009778 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 649831009779 SnoaL-like domain; Region: SnoaL_2; pfam12680 649831009780 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 649831009781 Protein of unknown function (DUF461); Region: DUF461; pfam04314 649831009782 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 649831009783 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 649831009784 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 649831009785 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 649831009786 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 649831009787 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 649831009788 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 649831009789 intersubunit interface [polypeptide binding]; other site 649831009790 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 649831009791 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 649831009792 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 649831009793 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 649831009794 dimer interface [polypeptide binding]; other site 649831009795 ABC-ATPase subunit interface; other site 649831009796 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 649831009797 dimerization interface [polypeptide binding]; other site 649831009798 putative DNA binding site [nucleotide binding]; other site 649831009799 helix_turn_helix, Arsenical Resistance Operon Repressor; Region: HTH_ARSR; smart00418 649831009800 putative Zn2+ binding site [ion binding]; other site 649831009801 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 649831009802 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 649831009803 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 649831009804 Ferritin-like domain; Region: Ferritin_2; pfam13668 649831009805 High-affinity nickel-transport protein; Region: NicO; cl00964 649831009806 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 649831009807 FAD binding pocket [chemical binding]; other site 649831009808 FAD binding motif [chemical binding]; other site 649831009809 phosphate binding motif [ion binding]; other site 649831009810 NAD binding pocket [chemical binding]; other site 649831009811 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 649831009812 putative active site [active] 649831009813 putative metal binding site [ion binding]; other site 649831009814 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 649831009815 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 649831009816 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 649831009817 AAA domain; Region: AAA_33; pfam13671 649831009818 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 649831009819 3D domain; Region: 3D; cl01439 649831009820 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 649831009821 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 649831009822 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831009823 H+ Antiporter protein; Region: 2A0121; TIGR00900 649831009824 putative substrate translocation pore; other site 649831009825 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831009826 MFS/sugar transport protein; Region: MFS_2; pfam13347 649831009827 putative substrate translocation pore; other site 649831009828 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 649831009829 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 649831009830 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 649831009831 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 649831009832 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 649831009833 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 649831009834 dimerization interface [polypeptide binding]; other site 649831009835 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 649831009836 NAD binding site [chemical binding]; other site 649831009837 ligand binding site [chemical binding]; other site 649831009838 catalytic site [active] 649831009839 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 649831009840 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 649831009841 acyl-activating enzyme (AAE) consensus motif; other site 649831009842 AMP binding site [chemical binding]; other site 649831009843 active site 649831009844 CoA binding site [chemical binding]; other site 649831009845 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 649831009846 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 649831009847 putative trimer interface [polypeptide binding]; other site 649831009848 putative CoA binding site [chemical binding]; other site 649831009849 colanic acid biosynthesis acetyltransferase WcaF; Region: WcaF; TIGR04008 649831009850 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 649831009851 putative trimer interface [polypeptide binding]; other site 649831009852 putative CoA binding site [chemical binding]; other site 649831009853 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 649831009854 Peptidase family M1; Region: Peptidase_M1; pfam01433 649831009855 Zn binding site [ion binding]; other site 649831009856 Carbohydrate binding domain (family 25); Region: CBM_25; cl04060 649831009857 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 649831009858 active site 649831009859 TIGR03086 family protein; Region: TIGR03086 649831009860 TIGR03086 family protein; Region: TIGR03086 649831009861 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 649831009862 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 649831009863 acyl-activating enzyme (AAE) consensus motif; other site 649831009864 AMP binding site [chemical binding]; other site 649831009865 active site 649831009866 CoA binding site [chemical binding]; other site 649831009867 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 649831009868 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 649831009869 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 649831009870 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 649831009871 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 649831009872 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 649831009873 Coenzyme A binding pocket [chemical binding]; other site 649831009874 Ricin-type beta-trefoil; Region: RICIN; smart00458 649831009875 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 649831009876 putative sugar binding sites [chemical binding]; other site 649831009877 Q-X-W motif; other site 649831009878 Glycosyl hydrolase catalytic core; Region: Glyco_hydro_cc; pfam11790 649831009879 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 649831009880 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 649831009881 active site 649831009882 catalytic site [active] 649831009883 amino acid transporter; Region: 2A0306; TIGR00909 649831009884 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 649831009885 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 649831009886 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 649831009887 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 649831009888 active site 649831009889 catalytic residues [active] 649831009890 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 649831009891 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 649831009892 DXD motif; other site 649831009893 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 649831009894 lipoyl-biotinyl attachment site [posttranslational modification]; other site 649831009895 HlyD family secretion protein; Region: HlyD_3; pfam13437 649831009896 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 649831009897 dimer interface [polypeptide binding]; other site 649831009898 substrate binding site [chemical binding]; other site 649831009899 metal binding sites [ion binding]; metal-binding site 649831009900 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 649831009901 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 649831009902 substrate binding site [chemical binding]; other site 649831009903 oxyanion hole (OAH) forming residues; other site 649831009904 trimer interface [polypeptide binding]; other site 649831009905 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 649831009906 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 649831009907 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 649831009908 DNA binding residues [nucleotide binding] 649831009909 putative dimer interface [polypeptide binding]; other site 649831009910 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 649831009911 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 649831009912 substrate binding site [chemical binding]; other site 649831009913 oxyanion hole (OAH) forming residues; other site 649831009914 trimer interface [polypeptide binding]; other site 649831009915 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 649831009916 putative active site [active] 649831009917 putative catalytic site [active] 649831009918 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 649831009919 Caspase domain; Region: Peptidase_C14; pfam00656 649831009920 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 649831009921 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 649831009922 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 649831009923 metal ion-dependent adhesion site (MIDAS); other site 649831009924 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 649831009925 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 649831009926 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 649831009927 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 649831009928 metal binding site [ion binding]; metal-binding site 649831009929 active site 649831009930 I-site; other site 649831009931 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 649831009932 Zn2+ binding site [ion binding]; other site 649831009933 Mg2+ binding site [ion binding]; other site 649831009934 Endonuclease I; Region: Endonuclease_1; pfam04231 649831009935 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 649831009936 active site 649831009937 catalytic residues [active] 649831009938 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 649831009939 Sulfatase; Region: Sulfatase; pfam00884 649831009940 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 649831009941 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 649831009942 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 649831009943 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 649831009944 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 649831009945 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 649831009946 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 649831009947 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 649831009948 active site 649831009949 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 649831009950 Beta-galactosidase, domain 2; Region: BetaGal_dom2; smart01029 649831009951 Beta-galactosidase, domain 2; Region: BetaGal_dom2; pfam10435 649831009952 Beta-galactosidase, domain 3; Region: BetaGal_dom3; pfam13363 649831009953 Beta-galactosidase jelly roll domain; Region: BetaGal_dom4_5; pfam13364 649831009954 Beta-galactosidase jelly roll domain; Region: BetaGal_dom4_5; pfam13364 649831009955 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 649831009956 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 649831009957 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 649831009958 putative metal binding site [ion binding]; other site 649831009959 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 649831009960 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 649831009961 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 649831009962 active site 649831009963 catalytic site [active] 649831009964 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 649831009965 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 649831009966 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 649831009967 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 649831009968 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 649831009969 NAD(P) binding site [chemical binding]; other site 649831009970 catalytic residues [active] 649831009971 Helix-turn-helix domain; Region: HTH_17; pfam12728 649831009972 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_2; cd06102 649831009973 dimer interface [polypeptide binding]; other site 649831009974 active site 649831009975 coenzyme A binding site [chemical binding]; other site 649831009976 citrylCoA binding site [chemical binding]; other site 649831009977 Citrate synthase; Region: Citrate_synt; pfam00285 649831009978 oxalacetate/citrate binding site [chemical binding]; other site 649831009979 catalytic triad [active] 649831009980 citrate synthase 2; Provisional; Region: PRK12350 649831009981 Citrate synthase; Region: Citrate_synt; pfam00285 649831009982 oxalacetate binding site [chemical binding]; other site 649831009983 citrylCoA binding site [chemical binding]; other site 649831009984 coenzyme A binding site [chemical binding]; other site 649831009985 catalytic triad [active] 649831009986 NB-ARC domain; Region: NB-ARC; pfam00931 649831009987 Tetratricopeptide repeat; Region: TPR_12; pfam13424 649831009988 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 649831009989 Tetratricopeptide repeat; Region: TPR_12; pfam13424 649831009990 binding surface 649831009991 TPR motif; other site 649831009992 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 649831009993 binding surface 649831009994 TPR motif; other site 649831009995 Tetratricopeptide repeat; Region: TPR_12; pfam13424 649831009996 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 649831009997 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 649831009998 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 649831009999 NAD binding site [chemical binding]; other site 649831010000 catalytic Zn binding site [ion binding]; other site 649831010001 structural Zn binding site [ion binding]; other site 649831010002 Transmembrane secretion effector; Region: MFS_3; pfam05977 649831010003 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 649831010004 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649831010005 dimer interface [polypeptide binding]; other site 649831010006 conserved gate region; other site 649831010007 ABC-ATPase subunit interface; other site 649831010008 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 649831010009 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649831010010 dimer interface [polypeptide binding]; other site 649831010011 conserved gate region; other site 649831010012 putative PBP binding loops; other site 649831010013 ABC-ATPase subunit interface; other site 649831010014 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 649831010015 Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270 649831010016 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 649831010017 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649831010018 S-adenosylmethionine binding site [chemical binding]; other site 649831010019 xanthine permease; Region: pbuX; TIGR03173 649831010020 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 649831010021 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 649831010022 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 649831010023 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 649831010024 tetramer interface [polypeptide binding]; other site 649831010025 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 649831010026 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 649831010027 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 649831010028 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 649831010029 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 649831010030 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 649831010031 ATP-grasp domain; Region: ATP-grasp_4; cl17255 649831010032 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 649831010033 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 649831010034 carboxyltransferase (CT) interaction site; other site 649831010035 biotinylation site [posttranslational modification]; other site 649831010036 Acetyl-CoA carboxylase, central region; Region: ACC_central; pfam08326 649831010037 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 649831010038 short chain dehydrogenase; Provisional; Region: PRK08219 649831010039 classical (c) SDRs; Region: SDR_c; cd05233 649831010040 NAD(P) binding site [chemical binding]; other site 649831010041 active site 649831010042 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649831010043 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649831010044 DNA binding residues [nucleotide binding] 649831010045 dimerization interface [polypeptide binding]; other site 649831010046 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 649831010047 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 649831010048 Ligand Binding Site [chemical binding]; other site 649831010049 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 649831010050 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 649831010051 Glycoside hydrolase family 15, N-terminal domain; Region: GH15_N; cd07430 649831010052 Domain interface; other site 649831010053 glucan 1,4-alpha-glucosidase; Region: glucan_glucosid; TIGR01535 649831010054 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 649831010055 DNA binding site [nucleotide binding] 649831010056 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 649831010057 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 649831010058 Tetratricopeptide repeat; Region: TPR_12; pfam13424 649831010059 Tetratricopeptide repeat; Region: TPR_12; pfam13424 649831010060 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 649831010061 binding surface 649831010062 TPR motif; other site 649831010063 Tetratricopeptide repeat; Region: TPR_12; pfam13424 649831010064 Tetratricopeptide repeat; Region: TPR_12; pfam13424 649831010065 Cellulose binding domain; Region: CBM_2; pfam00553 649831010066 Domain of unknown function (DUF4394); Region: DUF4394; pfam14339 649831010067 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 649831010068 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 649831010069 active site 649831010070 ATP binding site [chemical binding]; other site 649831010071 substrate binding site [chemical binding]; other site 649831010072 activation loop (A-loop); other site 649831010073 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 649831010074 active site 649831010075 zinc binding site [ion binding]; other site 649831010076 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 649831010077 Walker A/P-loop; other site 649831010078 ATP binding site [chemical binding]; other site 649831010079 Q-loop/lid; other site 649831010080 ABC transporter signature motif; other site 649831010081 Walker B; other site 649831010082 D-loop; other site 649831010083 H-loop/switch region; other site 649831010084 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 649831010085 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 649831010086 Walker A/P-loop; other site 649831010087 ATP binding site [chemical binding]; other site 649831010088 Q-loop/lid; other site 649831010089 ABC transporter signature motif; other site 649831010090 Walker B; other site 649831010091 D-loop; other site 649831010092 H-loop/switch region; other site 649831010093 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831010094 active site 649831010095 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649831010096 phosphorylation site [posttranslational modification] 649831010097 intermolecular recognition site; other site 649831010098 dimerization interface [polypeptide binding]; other site 649831010099 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649831010100 DNA binding residues [nucleotide binding] 649831010101 dimerization interface [polypeptide binding]; other site 649831010102 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 649831010103 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 649831010104 active site 649831010105 catalytic site [active] 649831010106 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 649831010107 Starch binding domain; Region: CBM_2; smart01065 649831010108 starch-binding site 2 [chemical binding]; other site 649831010109 starch-binding site 1 [chemical binding]; other site 649831010110 Bacterial Ig-like domain; Region: Big_5; pfam13205 649831010111 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 649831010112 DNA-binding site [nucleotide binding]; DNA binding site 649831010113 RNA-binding motif; other site 649831010114 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831010115 Major Facilitator Superfamily; Region: MFS_1; pfam07690 649831010116 putative substrate translocation pore; other site 649831010117 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 649831010118 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 649831010119 putative ligand binding site [chemical binding]; other site 649831010120 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 649831010121 Cytochrome P450; Region: p450; cl12078 649831010122 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 649831010123 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 649831010124 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 649831010125 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 649831010126 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 649831010127 RNA polymerase sigma-70 factor, Planctomycetaceae-specific subfamily 1; Region: Sig-70_plancto1; TIGR02984 649831010128 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 649831010129 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 649831010130 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 649831010131 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 649831010132 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 649831010133 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 649831010134 sugar binding site [chemical binding]; other site 649831010135 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 649831010136 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 649831010137 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 649831010138 catalytic site [active] 649831010139 BNR repeat-like domain; Region: BNR_2; pfam13088 649831010140 Asp-box motif; other site 649831010141 Alpha-lytic protease prodomain; Region: Pro_Al_protease; pfam02983 649831010142 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 649831010143 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 649831010144 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 649831010145 AAA ATPase domain; Region: AAA_16; pfam13191 649831010146 NB-ARC domain; Region: NB-ARC; pfam00931 649831010147 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 649831010148 TPR motif; other site 649831010149 binding surface 649831010150 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 649831010151 CoenzymeA binding site [chemical binding]; other site 649831010152 subunit interaction site [polypeptide binding]; other site 649831010153 PHB binding site; other site 649831010154 Cellulose binding domain; Region: CBM_2; pfam00553 649831010155 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 649831010156 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 649831010157 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 649831010158 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH6; cd08260 649831010159 putative NAD(P) binding site [chemical binding]; other site 649831010160 catalytic Zn binding site [ion binding]; other site 649831010161 structural Zn binding site [ion binding]; other site 649831010162 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 649831010163 active site 649831010164 metal binding site [ion binding]; metal-binding site 649831010165 Rhodanese Homology Domain; Region: RHOD; smart00450 649831010166 active site residue [active] 649831010167 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 649831010168 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649831010169 Walker A/P-loop; other site 649831010170 ATP binding site [chemical binding]; other site 649831010171 Q-loop/lid; other site 649831010172 ABC transporter signature motif; other site 649831010173 Walker B; other site 649831010174 D-loop; other site 649831010175 H-loop/switch region; other site 649831010176 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 649831010177 synthetase active site [active] 649831010178 NTP binding site [chemical binding]; other site 649831010179 metal binding site [ion binding]; metal-binding site 649831010180 LexA repressor; Validated; Region: PRK00215 649831010181 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 649831010182 putative DNA binding site [nucleotide binding]; other site 649831010183 putative Zn2+ binding site [ion binding]; other site 649831010184 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 649831010185 Catalytic site [active] 649831010186 PRC-barrel domain; Region: PRC; pfam05239 649831010187 Prokaryotic phospholipase A2; Region: Phospholip_A2_3; pfam09056 649831010188 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 649831010189 AAA domain; Region: AAA_30; pfam13604 649831010190 Family description; Region: UvrD_C_2; pfam13538 649831010191 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 649831010192 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 649831010193 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 649831010194 active site 649831010195 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 649831010196 active site 649831010197 metal binding site [ion binding]; metal-binding site 649831010198 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 649831010199 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 649831010200 metal binding site [ion binding]; metal-binding site 649831010201 active site 649831010202 I-site; other site 649831010203 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 649831010204 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 649831010205 cleavage site 649831010206 active site 649831010207 substrate binding sites [chemical binding]; other site 649831010208 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831010209 NAD(P) binding site [chemical binding]; other site 649831010210 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 649831010211 active site 649831010212 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 649831010213 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 649831010214 salt bridge; other site 649831010215 non-specific DNA binding site [nucleotide binding]; other site 649831010216 sequence-specific DNA binding site [nucleotide binding]; other site 649831010217 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 649831010218 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 649831010219 NodB motif; other site 649831010220 active site 649831010221 catalytic site [active] 649831010222 metal binding site [ion binding]; metal-binding site 649831010223 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649831010224 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831010225 intermolecular recognition site; other site 649831010226 active site 649831010227 dimerization interface [polypeptide binding]; other site 649831010228 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649831010229 DNA binding residues [nucleotide binding] 649831010230 dimerization interface [polypeptide binding]; other site 649831010231 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 649831010232 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831010233 ATP binding site [chemical binding]; other site 649831010234 Mg2+ binding site [ion binding]; other site 649831010235 G-X-G motif; other site 649831010236 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 649831010237 Zn binding site [ion binding]; other site 649831010238 DivIVA protein; Region: DivIVA; pfam05103 649831010239 DivIVA domain; Region: DivI1A_domain; TIGR03544 649831010240 Asp23 family; Region: Asp23; cl00574 649831010241 Nitronate monooxygenase; Region: NMO; pfam03060 649831010242 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 649831010243 FMN binding site [chemical binding]; other site 649831010244 substrate binding site [chemical binding]; other site 649831010245 putative catalytic residue [active] 649831010246 thymidine kinase; Provisional; Region: PRK04296 649831010247 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 649831010248 Transcriptional regulator [Transcription]; Region: IclR; COG1414 649831010249 Bacterial transcriptional regulator; Region: IclR; pfam01614 649831010250 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 649831010251 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 649831010252 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 649831010253 DNA binding residues [nucleotide binding] 649831010254 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 649831010255 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 649831010256 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 649831010257 active site 649831010258 Zn binding site [ion binding]; other site 649831010259 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 649831010260 Uncharacterized conserved protein (DUF2203); Region: DUF2203; pfam09969 649831010261 RNA polymerase factor sigma-70; Validated; Region: PRK08241 649831010262 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 649831010263 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 649831010264 DNA binding residues [nucleotide binding] 649831010265 SnoaL-like domain; Region: SnoaL_2; pfam12680 649831010266 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 649831010267 Clp protease; Region: CLP_protease; pfam00574 649831010268 oligomer interface [polypeptide binding]; other site 649831010269 active site residues [active] 649831010270 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831010271 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 649831010272 active site 649831010273 Predicted integral membrane protein [Function unknown]; Region: COG0392 649831010274 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831010275 putative substrate translocation pore; other site 649831010276 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831010277 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_6; cd01844 649831010278 active site 649831010279 catalytic triad [active] 649831010280 oxyanion hole [active] 649831010281 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831010282 WHG domain; Region: WHG; pfam13305 649831010283 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 649831010284 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 649831010285 active site 649831010286 catalytic site [active] 649831010287 Family description; Region: VCBS; pfam13517 649831010288 Glyoxal oxidase N-terminus; Region: Glyoxal_oxid_N; pfam07250 649831010289 C-terminal Early set domain associated with the catalytic domain of galactose oxidase; Region: E_set_GO_C; cd02851 649831010290 AAA ATPase domain; Region: AAA_16; pfam13191 649831010291 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 649831010292 Protein of unknown function (DUF664); Region: DUF664; pfam04978 649831010293 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 649831010294 putative DNA binding site [nucleotide binding]; other site 649831010295 putative Zn2+ binding site [ion binding]; other site 649831010296 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 649831010297 putative hydrophobic ligand binding site [chemical binding]; other site 649831010298 Amb_all domain; Region: Amb_all; smart00656 649831010299 Family description; Region: VCBS; pfam13517 649831010300 Family description; Region: VCBS; pfam13517 649831010301 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 649831010302 DNA binding site [nucleotide binding] 649831010303 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 649831010304 NACHT domain; Region: NACHT; pfam05729 649831010305 Tetratricopeptide repeat; Region: TPR_12; pfam13424 649831010306 Tetratricopeptide repeat; Region: TPR_12; pfam13424 649831010307 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 649831010308 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 649831010309 CheB methylesterase; Region: CheB_methylest; pfam01339 649831010310 Chitin binding domain; Region: Chitin_bind_3; pfam03067 649831010311 Cellulose binding domain; Region: CBM_2; pfam00553 649831010312 Transcriptional regulator [Transcription]; Region: LysR; COG0583 649831010313 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 649831010314 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 649831010315 dimerization interface [polypeptide binding]; other site 649831010316 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831010317 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 649831010318 short chain dehydrogenase; Validated; Region: PRK08264 649831010319 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831010320 NAD(P) binding site [chemical binding]; other site 649831010321 active site 649831010322 Fn3 associated; Region: Fn3_assoc; pfam13287 649831010323 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 649831010324 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 649831010325 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 649831010326 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 649831010327 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 649831010328 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 649831010329 DNA binding residues [nucleotide binding] 649831010330 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 649831010331 Transcriptional regulators [Transcription]; Region: PurR; COG1609 649831010332 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 649831010333 DNA binding site [nucleotide binding] 649831010334 domain linker motif; other site 649831010335 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 649831010336 dimerization interface [polypeptide binding]; other site 649831010337 ligand binding site [chemical binding]; other site 649831010338 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 649831010339 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 649831010340 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 649831010341 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649831010342 Walker A/P-loop; other site 649831010343 ATP binding site [chemical binding]; other site 649831010344 Q-loop/lid; other site 649831010345 ABC transporter signature motif; other site 649831010346 Walker B; other site 649831010347 D-loop; other site 649831010348 H-loop/switch region; other site 649831010349 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 649831010350 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649831010351 dimer interface [polypeptide binding]; other site 649831010352 conserved gate region; other site 649831010353 putative PBP binding loops; other site 649831010354 ABC-ATPase subunit interface; other site 649831010355 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 649831010356 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649831010357 dimer interface [polypeptide binding]; other site 649831010358 conserved gate region; other site 649831010359 putative PBP binding loops; other site 649831010360 ABC-ATPase subunit interface; other site 649831010361 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 649831010362 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 649831010363 metal binding site [ion binding]; metal-binding site 649831010364 substrate binding pocket [chemical binding]; other site 649831010365 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 649831010366 DEAD-like helicases superfamily; Region: DEXDc; smart00487 649831010367 ATP binding site [chemical binding]; other site 649831010368 Mg++ binding site [ion binding]; other site 649831010369 motif III; other site 649831010370 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 649831010371 nucleotide binding region [chemical binding]; other site 649831010372 ATP-binding site [chemical binding]; other site 649831010373 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 649831010374 RNA binding site [nucleotide binding]; other site 649831010375 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 649831010376 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 649831010377 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 649831010378 catalytic residue [active] 649831010379 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 649831010380 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418 649831010381 active site 649831010382 hydroperoxidase II; Provisional; Region: katE; PRK11249 649831010383 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 649831010384 heme binding pocket [chemical binding]; other site 649831010385 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 649831010386 conserved cys residue [active] 649831010387 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 649831010388 classical (c) SDRs; Region: SDR_c; cd05233 649831010389 NAD(P) binding site [chemical binding]; other site 649831010390 active site 649831010391 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 649831010392 Cytochrome P450; Region: p450; cl12078 649831010393 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 649831010394 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 649831010395 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 649831010396 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 649831010397 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 649831010398 active site 649831010399 Transcriptional regulators [Transcription]; Region: PurR; COG1609 649831010400 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 649831010401 DNA binding site [nucleotide binding] 649831010402 domain linker motif; other site 649831010403 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 649831010404 ligand binding site [chemical binding]; other site 649831010405 dimerization interface (open form) [polypeptide binding]; other site 649831010406 dimerization interface (closed form) [polypeptide binding]; other site 649831010407 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 649831010408 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 649831010409 putative ligand binding site [chemical binding]; other site 649831010410 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 649831010411 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 649831010412 Walker A/P-loop; other site 649831010413 ATP binding site [chemical binding]; other site 649831010414 Q-loop/lid; other site 649831010415 ABC transporter signature motif; other site 649831010416 Walker B; other site 649831010417 D-loop; other site 649831010418 H-loop/switch region; other site 649831010419 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 649831010420 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 649831010421 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 649831010422 TM-ABC transporter signature motif; other site 649831010423 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 649831010424 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 649831010425 TM-ABC transporter signature motif; other site 649831010426 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 649831010427 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 649831010428 metal ion-dependent adhesion site (MIDAS); other site 649831010429 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 649831010430 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 649831010431 substrate binding site [chemical binding]; other site 649831010432 active site 649831010433 Methane oxygenase PmoA; Region: PmoA; pfam14100 649831010434 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 649831010435 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 649831010436 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 649831010437 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 649831010438 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 649831010439 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 649831010440 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 649831010441 metal binding site [ion binding]; metal-binding site 649831010442 substrate binding pocket [chemical binding]; other site 649831010443 glucuronate isomerase; Reviewed; Region: PRK02925 649831010444 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 649831010445 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 649831010446 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 649831010447 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 649831010448 Transcriptional regulators [Transcription]; Region: PurR; COG1609 649831010449 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 649831010450 DNA binding site [nucleotide binding] 649831010451 domain linker motif; other site 649831010452 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 649831010453 dimerization interface [polypeptide binding]; other site 649831010454 ligand binding site [chemical binding]; other site 649831010455 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 649831010456 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 649831010457 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 649831010458 Myb/SANT-like DNA-binding domain; Region: Myb_DNA-bind_3; pfam12776 649831010459 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649831010460 dimer interface [polypeptide binding]; other site 649831010461 putative PBP binding loops; other site 649831010462 ABC-ATPase subunit interface; other site 649831010463 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 649831010464 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649831010465 dimer interface [polypeptide binding]; other site 649831010466 conserved gate region; other site 649831010467 putative PBP binding loops; other site 649831010468 ABC-ATPase subunit interface; other site 649831010469 Copper type II ascorbate-dependent monooxygenase, N-terminal domain; Region: Cu2_monooxygen; pfam01082 649831010470 Copper type II ascorbate-dependent monooxygenase, C-terminal domain; Region: Cu2_monoox_C; pfam03712 649831010471 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 649831010472 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 649831010473 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 649831010474 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 649831010475 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 649831010476 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 649831010477 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 649831010478 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 649831010479 DNA binding residues [nucleotide binding] 649831010480 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 649831010481 DivIVA protein; Region: DivIVA; pfam05103 649831010482 DivIVA domain; Region: DivI1A_domain; TIGR03544 649831010483 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 649831010484 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 649831010485 Transcriptional regulators [Transcription]; Region: FadR; COG2186 649831010486 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 649831010487 DNA-binding site [nucleotide binding]; DNA binding site 649831010488 FCD domain; Region: FCD; pfam07729 649831010489 hypothetical protein; Validated; Region: PRK06201 649831010490 hypothetical protein; Provisional; Region: PRK09262 649831010491 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 649831010492 Domain of unknown function (DUF1932); Region: DUF1932; pfam09130 649831010493 Amidohydrolase; Region: Amidohydro_2; pfam04909 649831010494 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 649831010495 active site 649831010496 putative catalytic site [active] 649831010497 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 649831010498 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649831010499 S-adenosylmethionine binding site [chemical binding]; other site 649831010500 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 649831010501 Glycosyl hydrolase family 43; Region: GH43_4; cd08983 649831010502 active site 649831010503 Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270 649831010504 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 649831010505 active site 649831010506 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 649831010507 Phosphotransferase enzyme family; Region: APH; pfam01636 649831010508 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831010509 NAD(P) binding site [chemical binding]; other site 649831010510 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831010511 active site 649831010512 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 649831010513 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 649831010514 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 649831010515 Protein of unknown function (DUF328); Region: DUF328; cl01143 649831010516 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 649831010517 anti sigma factor interaction site; other site 649831010518 regulatory phosphorylation site [posttranslational modification]; other site 649831010519 CopC domain; Region: CopC; pfam04234 649831010520 phosphoglucomutase; Validated; Region: PRK07564 649831010521 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 649831010522 active site 649831010523 substrate binding site [chemical binding]; other site 649831010524 metal binding site [ion binding]; metal-binding site 649831010525 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 649831010526 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 649831010527 metal binding site [ion binding]; metal-binding site 649831010528 active site 649831010529 I-site; other site 649831010530 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 649831010531 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 649831010532 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 649831010533 tetramer interface [polypeptide binding]; other site 649831010534 active site 649831010535 Mg2+/Mn2+ binding site [ion binding]; other site 649831010536 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 649831010537 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 649831010538 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 649831010539 PemK-like protein; Region: PemK; pfam02452 649831010540 Domain of unknown function (DUF222); Region: DUF222; pfam02720 649831010541 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 649831010542 active site 649831010543 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 649831010544 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 649831010545 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 649831010546 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 649831010547 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 649831010548 active site 649831010549 non-prolyl cis peptide bond; other site 649831010550 Isochorismatase family; Region: Isochorismatase; pfam00857 649831010551 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 649831010552 catalytic triad [active] 649831010553 conserved cis-peptide bond; other site 649831010554 pyrimidine utilization protein A; Region: RutA; TIGR03612 649831010555 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 649831010556 NMT1/THI5 like; Region: NMT1; pfam09084 649831010557 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 649831010558 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649831010559 putative PBP binding loops; other site 649831010560 ABC-ATPase subunit interface; other site 649831010561 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 649831010562 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 649831010563 Walker A/P-loop; other site 649831010564 ATP binding site [chemical binding]; other site 649831010565 Q-loop/lid; other site 649831010566 ABC transporter signature motif; other site 649831010567 Walker B; other site 649831010568 D-loop; other site 649831010569 H-loop/switch region; other site 649831010570 PAS fold; Region: PAS_3; pfam08447 649831010571 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 649831010572 spore photoproduct lyase; Region: photo_TT_lyase; cl15393 649831010573 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 649831010574 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 649831010575 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 649831010576 Beta-lactamase; Region: Beta-lactamase; pfam00144 649831010577 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 649831010578 nudix motif; other site 649831010579 FOG: WD40 repeat [General function prediction only]; Region: COG2319 649831010580 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 649831010581 structural tetrad; other site 649831010582 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 649831010583 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 649831010584 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 649831010585 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 649831010586 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 649831010587 molybdopterin cofactor binding site; other site 649831010588 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 649831010589 4Fe-4S binding domain; Region: Fer4_6; pfam12837 649831010590 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 649831010591 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 649831010592 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK13964 649831010593 active site 649831010594 nucleotide binding site [chemical binding]; other site 649831010595 HIGH motif; other site 649831010596 KMSKS motif; other site 649831010597 Epoxide hydrolase N terminus; Region: EHN; pfam06441 649831010598 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 649831010599 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 649831010600 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 649831010601 active site 649831010602 ATP binding site [chemical binding]; other site 649831010603 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 649831010604 Leucine carboxyl methyltransferase; Region: LCM; cl01306 649831010605 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 649831010606 putative hydrophobic ligand binding site [chemical binding]; other site 649831010607 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 649831010608 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831010609 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 649831010610 TAP-like protein; Region: Abhydrolase_4; pfam08386 649831010611 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 649831010612 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 649831010613 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830 649831010614 active site 649831010615 catalytic triad [active] 649831010616 oxyanion hole [active] 649831010617 Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648 649831010618 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 649831010619 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 649831010620 hypothetical protein; Provisional; Region: PRK06547 649831010621 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 649831010622 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 649831010623 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 649831010624 spore photoproduct lyase family protein; Region: lyase_spl_fam; TIGR03886 649831010625 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831010626 Major Facilitator Superfamily; Region: MFS_1; pfam07690 649831010627 putative substrate translocation pore; other site 649831010628 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831010629 benzoate transport; Region: 2A0115; TIGR00895 649831010630 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831010631 putative substrate translocation pore; other site 649831010632 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 649831010633 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 649831010634 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 649831010635 active site 649831010636 catalytic site [active] 649831010637 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649831010638 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831010639 active site 649831010640 phosphorylation site [posttranslational modification] 649831010641 intermolecular recognition site; other site 649831010642 dimerization interface [polypeptide binding]; other site 649831010643 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649831010644 DNA binding residues [nucleotide binding] 649831010645 dimerization interface [polypeptide binding]; other site 649831010646 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 649831010647 Histidine kinase; Region: HisKA_3; pfam07730 649831010648 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 649831010649 ATP binding site [chemical binding]; other site 649831010650 Mg2+ binding site [ion binding]; other site 649831010651 G-X-G motif; other site 649831010652 ChaB; Region: ChaB; pfam06150 649831010653 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 649831010654 Protein of unknown function (DUF1810); Region: DUF1810; pfam08837 649831010655 FAD dependent oxidoreductase; Region: DAO; pfam01266 649831010656 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 649831010657 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 649831010658 TIGR03943 family protein; Region: TIGR03943 649831010659 Predicted permease; Region: DUF318; cl17795 649831010660 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 649831010661 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 649831010662 active site 649831010663 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649831010664 S-adenosylmethionine binding site [chemical binding]; other site 649831010665 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831010666 Major Facilitator Superfamily; Region: MFS_1; pfam07690 649831010667 putative substrate translocation pore; other site 649831010668 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831010669 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 649831010670 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 649831010671 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 649831010672 sugar binding site [chemical binding]; other site 649831010673 Transcriptional regulators [Transcription]; Region: PurR; COG1609 649831010674 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 649831010675 DNA binding site [nucleotide binding] 649831010676 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 649831010677 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 649831010678 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 649831010679 PAS domain S-box; Region: sensory_box; TIGR00229 649831010680 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 649831010681 putative active site [active] 649831010682 heme pocket [chemical binding]; other site 649831010683 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 649831010684 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 649831010685 metal binding site [ion binding]; metal-binding site 649831010686 active site 649831010687 I-site; other site 649831010688 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 649831010689 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 649831010690 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 649831010691 Coenzyme A binding pocket [chemical binding]; other site 649831010692 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 649831010693 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 649831010694 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 649831010695 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 649831010696 CGNR zinc finger; Region: zf-CGNR; pfam11706 649831010697 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 649831010698 Coenzyme A binding pocket [chemical binding]; other site 649831010699 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 649831010700 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 649831010701 active site 649831010702 catalytic site [active] 649831010703 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 649831010704 Predicted acetyltransferase [General function prediction only]; Region: COG3393 649831010705 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 649831010706 Coenzyme A binding pocket [chemical binding]; other site 649831010707 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831010708 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 649831010709 NAD(P) binding site [chemical binding]; other site 649831010710 active site 649831010711 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 649831010712 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 649831010713 salt bridge; other site 649831010714 non-specific DNA binding site [nucleotide binding]; other site 649831010715 sequence-specific DNA binding site [nucleotide binding]; other site 649831010716 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 649831010717 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831010718 active site 649831010719 phosphorylation site [posttranslational modification] 649831010720 intermolecular recognition site; other site 649831010721 dimerization interface [polypeptide binding]; other site 649831010722 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 649831010723 DNA binding site [nucleotide binding] 649831010724 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 649831010725 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 649831010726 dimerization interface [polypeptide binding]; other site 649831010727 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 649831010728 dimer interface [polypeptide binding]; other site 649831010729 phosphorylation site [posttranslational modification] 649831010730 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831010731 ATP binding site [chemical binding]; other site 649831010732 Mg2+ binding site [ion binding]; other site 649831010733 G-X-G motif; other site 649831010734 Predicted membrane protein [Function unknown]; Region: COG3463 649831010735 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 649831010736 Domains similar to the eukaryotic reeler domain and bacterial cohesins; Region: Reeler_cohesin_like; cl14606 649831010737 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 649831010738 5'-3' exonuclease; Region: 53EXOc; smart00475 649831010739 active site 649831010740 metal binding site 1 [ion binding]; metal-binding site 649831010741 putative 5' ssDNA interaction site; other site 649831010742 metal binding site 3; metal-binding site 649831010743 metal binding site 2 [ion binding]; metal-binding site 649831010744 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 649831010745 putative DNA binding site [nucleotide binding]; other site 649831010746 putative metal binding site [ion binding]; other site 649831010747 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 649831010748 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 649831010749 active site 649831010750 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 649831010751 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 649831010752 putative DNA binding site [nucleotide binding]; other site 649831010753 putative Zn2+ binding site [ion binding]; other site 649831010754 AsnC family; Region: AsnC_trans_reg; pfam01037 649831010755 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 649831010756 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 649831010757 dimer interface [polypeptide binding]; other site 649831010758 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 649831010759 HTH domain; Region: HTH_11; pfam08279 649831010760 WYL domain; Region: WYL; pfam13280 649831010761 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 649831010762 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831010763 active site 649831010764 phosphorylation site [posttranslational modification] 649831010765 intermolecular recognition site; other site 649831010766 dimerization interface [polypeptide binding]; other site 649831010767 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 649831010768 DNA binding site [nucleotide binding] 649831010769 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649831010770 S-adenosylmethionine binding site [chemical binding]; other site 649831010771 CsbD-like; Region: CsbD; cl17424 649831010772 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 649831010773 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 649831010774 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 649831010775 active site 649831010776 D-Lysine 5,6-aminomutase alpha subunit; Region: Lys-AminoMut_A; pfam09043 649831010777 D-Lysine 5,6-aminomutase alpha subunit; Region: Lys-AminoMut_A; pfam09043 649831010778 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 649831010779 B12 binding site [chemical binding]; other site 649831010780 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 649831010781 active site 2 [active] 649831010782 MutL protein; Region: MutL; pfam13941 649831010783 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 649831010784 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 649831010785 putative active site [active] 649831010786 catalytic triad [active] 649831010787 putative dimer interface [polypeptide binding]; other site 649831010788 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 649831010789 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 649831010790 Ligand binding site; other site 649831010791 Putative Catalytic site; other site 649831010792 DXD motif; other site 649831010793 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 649831010794 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 649831010795 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 649831010796 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 649831010797 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 649831010798 Phosphotransferase enzyme family; Region: APH; pfam01636 649831010799 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 649831010800 active site 649831010801 ATP binding site [chemical binding]; other site 649831010802 substrate binding site [chemical binding]; other site 649831010803 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 649831010804 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 649831010805 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 649831010806 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 649831010807 active site 649831010808 catalytic residues [active] 649831010809 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 649831010810 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 649831010811 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 649831010812 motif II; other site 649831010813 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 649831010814 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 649831010815 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 649831010816 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 649831010817 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831010818 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 649831010819 hypothetical protein; Provisional; Region: PRK07588 649831010820 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831010821 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 649831010822 active site 649831010823 catalytic site [active] 649831010824 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 649831010825 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 649831010826 active site 649831010827 catalytic tetrad [active] 649831010828 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 649831010829 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 649831010830 Domain of unknown function (DUF336); Region: DUF336; cl01249 649831010831 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 649831010832 putative phosphate binding site [ion binding]; other site 649831010833 putative catalytic site [active] 649831010834 putative phosphate binding site [ion binding]; other site 649831010835 putative metal binding site [ion binding]; other site 649831010836 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 649831010837 MarR family; Region: MarR; pfam01047 649831010838 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 649831010839 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 649831010840 TAP-like protein; Region: Abhydrolase_4; pfam08386 649831010841 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 649831010842 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 649831010843 active site 649831010844 DNA binding site [nucleotide binding] 649831010845 Int/Topo IB signature motif; other site 649831010846 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 649831010847 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 649831010848 DNA binding residues [nucleotide binding] 649831010849 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 649831010850 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 649831010851 NAD(P) binding site [chemical binding]; other site 649831010852 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 649831010853 Cupin; Region: Cupin_6; pfam12852 649831010854 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 649831010855 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 649831010856 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 649831010857 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 649831010858 DNA-binding site [nucleotide binding]; DNA binding site 649831010859 Vacuole effluxer Atg22 like; Region: ATG22; pfam11700 649831010860 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 649831010861 Dynamin family; Region: Dynamin_N; pfam00350 649831010862 G1 box; other site 649831010863 GTP/Mg2+ binding site [chemical binding]; other site 649831010864 G2 box; other site 649831010865 Switch I region; other site 649831010866 G3 box; other site 649831010867 Switch II region; other site 649831010868 G4 box; other site 649831010869 G5 box; other site 649831010870 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 649831010871 Dynamin family; Region: Dynamin_N; pfam00350 649831010872 G1 box; other site 649831010873 GTP/Mg2+ binding site [chemical binding]; other site 649831010874 G2 box; other site 649831010875 Switch I region; other site 649831010876 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649831010877 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649831010878 DNA binding residues [nucleotide binding] 649831010879 dimerization interface [polypeptide binding]; other site 649831010880 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 649831010881 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831010882 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 649831010883 Cytochrome P450; Region: p450; cl12078 649831010884 Protein of unknown function (DUF1271); Region: DUF1271; pfam06902 649831010885 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 649831010886 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 649831010887 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 649831010888 putative acyl-acceptor binding pocket; other site 649831010889 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 649831010890 Cytochrome P450; Region: p450; cl12078 649831010891 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 649831010892 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 649831010893 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 649831010894 active site 649831010895 Int/Topo IB signature motif; other site 649831010896 DNA binding site [nucleotide binding] 649831010897 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 649831010898 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649831010899 Walker A/P-loop; other site 649831010900 ATP binding site [chemical binding]; other site 649831010901 Q-loop/lid; other site 649831010902 ABC transporter signature motif; other site 649831010903 Walker B; other site 649831010904 D-loop; other site 649831010905 H-loop/switch region; other site 649831010906 ABC transporter; Region: ABC_tran_2; pfam12848 649831010907 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 649831010908 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 649831010909 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 649831010910 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 649831010911 DNA binding residues [nucleotide binding] 649831010912 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649831010913 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831010914 active site 649831010915 phosphorylation site [posttranslational modification] 649831010916 intermolecular recognition site; other site 649831010917 dimerization interface [polypeptide binding]; other site 649831010918 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649831010919 DNA binding residues [nucleotide binding] 649831010920 dimerization interface [polypeptide binding]; other site 649831010921 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 649831010922 Histidine kinase; Region: HisKA_3; pfam07730 649831010923 ABC-2 type transporter; Region: ABC2_membrane; cl17235 649831010924 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 649831010925 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 649831010926 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649831010927 Walker A/P-loop; other site 649831010928 ATP binding site [chemical binding]; other site 649831010929 Q-loop/lid; other site 649831010930 ABC transporter signature motif; other site 649831010931 Walker B; other site 649831010932 D-loop; other site 649831010933 H-loop/switch region; other site 649831010934 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831010935 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 649831010936 NAD(P) binding site [chemical binding]; other site 649831010937 active site 649831010938 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 649831010939 IucA / IucC family; Region: IucA_IucC; pfam04183 649831010940 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 649831010941 IucA / IucC family; Region: IucA_IucC; pfam04183 649831010942 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 649831010943 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 649831010944 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 649831010945 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 649831010946 catalytic residue [active] 649831010947 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 649831010948 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 649831010949 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 649831010950 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 649831010951 active site 649831010952 catalytic residues [active] 649831010953 metal binding site [ion binding]; metal-binding site 649831010954 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 649831010955 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 649831010956 salt bridge; other site 649831010957 non-specific DNA binding site [nucleotide binding]; other site 649831010958 sequence-specific DNA binding site [nucleotide binding]; other site 649831010959 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831010960 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 649831010961 NAD(P) binding site [chemical binding]; other site 649831010962 active site 649831010963 glycine dehydrogenase; Provisional; Region: PRK05367 649831010964 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 649831010965 tetramer interface [polypeptide binding]; other site 649831010966 pyridoxal 5'-phosphate binding site [chemical binding]; other site 649831010967 catalytic residue [active] 649831010968 Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG1003 649831010969 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 649831010970 catalytic residue [active] 649831010971 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 649831010972 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 649831010973 active site 649831010974 catalytic tetrad [active] 649831010975 Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417 649831010976 Domain of unknown function (DUF4396); Region: DUF4396; pfam14342 649831010977 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 649831010978 active site 649831010979 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 649831010980 catalytic tetrad [active] 649831010981 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 649831010982 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 649831010983 acyl-activating enzyme (AAE) consensus motif; other site 649831010984 AMP binding site [chemical binding]; other site 649831010985 active site 649831010986 CoA binding site [chemical binding]; other site 649831010987 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 649831010988 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 649831010989 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 649831010990 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831010991 D-galactonate transporter; Region: 2A0114; TIGR00893 649831010992 putative substrate translocation pore; other site 649831010993 Carboxylesterase family; Region: COesterase; pfam00135 649831010994 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 649831010995 substrate binding pocket [chemical binding]; other site 649831010996 catalytic triad [active] 649831010997 DEAD-like helicases superfamily; Region: DEXDc; smart00487 649831010998 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 649831010999 ATP binding site [chemical binding]; other site 649831011000 putative Mg++ binding site [ion binding]; other site 649831011001 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 649831011002 nucleotide binding region [chemical binding]; other site 649831011003 ATP-binding site [chemical binding]; other site 649831011004 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 649831011005 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 649831011006 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831011007 PAS fold; Region: PAS_4; pfam08448 649831011008 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 649831011009 Methyltransferase domain; Region: Methyltransf_11; pfam08241 649831011010 S-adenosylmethionine binding site [chemical binding]; other site 649831011011 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 649831011012 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 649831011013 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 649831011014 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 649831011015 DNA binding residues [nucleotide binding] 649831011016 Bifunctional nuclease; Region: DNase-RNase; pfam02577 649831011017 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 649831011018 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 649831011019 DNA binding residues [nucleotide binding] 649831011020 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 649831011021 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 649831011022 phosphopeptide binding site; other site 649831011023 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 649831011024 lipoyl attachment site [posttranslational modification]; other site 649831011025 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 649831011026 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 649831011027 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 649831011028 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 649831011029 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 649831011030 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 649831011031 metal ion-dependent adhesion site (MIDAS); other site 649831011032 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 649831011033 Phenazine biosynthesis-like protein; Region: PhzC-PhzF; pfam02567 649831011034 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 649831011035 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649831011036 Walker A/P-loop; other site 649831011037 ATP binding site [chemical binding]; other site 649831011038 Q-loop/lid; other site 649831011039 ABC transporter signature motif; other site 649831011040 Walker B; other site 649831011041 D-loop; other site 649831011042 H-loop/switch region; other site 649831011043 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 649831011044 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 649831011045 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 649831011046 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 649831011047 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 649831011048 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 649831011049 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 649831011050 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 649831011051 oligomer interface; other site 649831011052 ligand binding site; other site 649831011053 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 649831011054 dimer interface [polypeptide binding]; other site 649831011055 N-terminal domain interface [polypeptide binding]; other site 649831011056 sulfate 1 binding site; other site 649831011057 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 649831011058 putative hydrophobic ligand binding site [chemical binding]; other site 649831011059 Barstar_SaI14_like contains sequences that are similar to SaI14, an RNAase inhibitor, which are members of the Barstar family. Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds...; Region: Barstar_SaI14_like; cd05143 649831011060 putative RNAase interaction site [polypeptide binding]; other site 649831011061 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; cl17722 649831011062 Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206 649831011063 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 649831011064 active site 649831011065 catalytic residues [active] 649831011066 DNA binding site [nucleotide binding] 649831011067 Int/Topo IB signature motif; other site 649831011068 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 649831011069 Integrase core domain; Region: rve; pfam00665 649831011070 Homeodomain-like domain; Region: HTH_23; cl17451 649831011071 Protein of unknown function (DUF664); Region: DUF664; pfam04978 649831011072 DinB superfamily; Region: DinB_2; pfam12867 649831011073 Uncharacterized protein conserved in archaea [Function unknown]; Region: COG4034 649831011074 Helix-turn-helix domain; Region: HTH_18; pfam12833 649831011075 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 649831011076 Domain of unknown function (DUF4331); Region: DUF4331; pfam14224 649831011077 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08651 649831011078 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 649831011079 metal binding site [ion binding]; metal-binding site 649831011080 dimer interface [polypeptide binding]; other site 649831011081 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 649831011082 active site residue [active] 649831011083 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 649831011084 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 649831011085 Homeodomain-like domain; Region: HTH_23; cl17451 649831011086 Integrase core domain; Region: rve; pfam00665 649831011087 Integrase core domain; Region: rve_3; pfam13683 649831011088 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 649831011089 homotrimer interaction site [polypeptide binding]; other site 649831011090 putative active site [active] 649831011091 Histidine kinase; Region: HisKA_3; pfam07730 649831011092 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 649831011093 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649831011094 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831011095 active site 649831011096 phosphorylation site [posttranslational modification] 649831011097 intermolecular recognition site; other site 649831011098 dimerization interface [polypeptide binding]; other site 649831011099 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649831011100 DNA binding residues [nucleotide binding] 649831011101 dimerization interface [polypeptide binding]; other site 649831011102 Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067 649831011103 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 649831011104 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 649831011105 active site 649831011106 dimer interface [polypeptide binding]; other site 649831011107 non-prolyl cis peptide bond; other site 649831011108 insertion regions; other site 649831011109 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 649831011110 Domain of unknown function (DUF4360); Region: DUF4360; pfam14273 649831011111 Domain of unknown function (DUF4360); Region: DUF4360; pfam14273 649831011112 hypothetical protein; Provisional; Region: PRK08317 649831011113 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649831011114 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 649831011115 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 649831011116 non-specific DNA binding site [nucleotide binding]; other site 649831011117 salt bridge; other site 649831011118 sequence-specific DNA binding site [nucleotide binding]; other site 649831011119 Cupin domain; Region: Cupin_2; pfam07883 649831011120 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 649831011121 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 649831011122 Walker A/P-loop; other site 649831011123 ATP binding site [chemical binding]; other site 649831011124 Q-loop/lid; other site 649831011125 ABC transporter signature motif; other site 649831011126 Walker B; other site 649831011127 D-loop; other site 649831011128 H-loop/switch region; other site 649831011129 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 649831011130 Walker A/P-loop; other site 649831011131 ATP binding site [chemical binding]; other site 649831011132 Q-loop/lid; other site 649831011133 ABC transporter signature motif; other site 649831011134 Walker B; other site 649831011135 D-loop; other site 649831011136 H-loop/switch region; other site 649831011137 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 649831011138 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 649831011139 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649831011140 putative PBP binding loops; other site 649831011141 dimer interface [polypeptide binding]; other site 649831011142 ABC-ATPase subunit interface; other site 649831011143 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 649831011144 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649831011145 conserved gate region; other site 649831011146 ABC-ATPase subunit interface; other site 649831011147 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 649831011148 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 649831011149 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 649831011150 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 649831011151 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 649831011152 [2Fe-2S] cluster binding site [ion binding]; other site 649831011153 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 649831011154 putative alpha subunit interface [polypeptide binding]; other site 649831011155 putative active site [active] 649831011156 putative substrate binding site [chemical binding]; other site 649831011157 Fe binding site [ion binding]; other site 649831011158 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 649831011159 hydroxyglutarate oxidase; Provisional; Region: PRK11728 649831011160 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 649831011161 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 649831011162 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 649831011163 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 649831011164 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 649831011165 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 649831011166 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 649831011167 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 649831011168 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649831011169 dimer interface [polypeptide binding]; other site 649831011170 conserved gate region; other site 649831011171 ABC-ATPase subunit interface; other site 649831011172 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 649831011173 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 649831011174 Walker A/P-loop; other site 649831011175 ATP binding site [chemical binding]; other site 649831011176 Q-loop/lid; other site 649831011177 ABC transporter signature motif; other site 649831011178 Walker B; other site 649831011179 D-loop; other site 649831011180 H-loop/switch region; other site 649831011181 choline dehydrogenase; Validated; Region: PRK02106 649831011182 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 649831011183 Domain of unknown function (DUF4386); Region: DUF4386; pfam14329 649831011184 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 649831011185 Protein of unknown function (DUF2397); Region: DUF2397; pfam09660 649831011186 TIGR02677 family protein; Region: TIGR02677 649831011187 Protein of unknown function (DUF2398); Region: DUF2398; cl09875 649831011188 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 649831011189 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 649831011190 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 649831011191 Serine hydrolase; Region: Ser_hydrolase; cl17834 649831011192 putative alpha-glucosidase; Provisional; Region: PRK10658 649831011193 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 649831011194 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 649831011195 active site 649831011196 homotrimer interface [polypeptide binding]; other site 649831011197 catalytic site [active] 649831011198 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 649831011199 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 649831011200 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649831011201 dimer interface [polypeptide binding]; other site 649831011202 conserved gate region; other site 649831011203 putative PBP binding loops; other site 649831011204 ABC-ATPase subunit interface; other site 649831011205 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649831011206 dimer interface [polypeptide binding]; other site 649831011207 conserved gate region; other site 649831011208 putative PBP binding loops; other site 649831011209 ABC-ATPase subunit interface; other site 649831011210 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 649831011211 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 649831011212 Transcriptional regulators [Transcription]; Region: PurR; COG1609 649831011213 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 649831011214 DNA binding site [nucleotide binding] 649831011215 domain linker motif; other site 649831011216 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 649831011217 dimerization interface [polypeptide binding]; other site 649831011218 ligand binding site [chemical binding]; other site 649831011219 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 649831011220 Beta-galactosidase, domain 2; Region: BetaGal_dom2; smart01029 649831011221 Beta-galactosidase, domain 2; Region: BetaGal_dom2; pfam10435 649831011222 Beta-galactosidase, domain 3; Region: BetaGal_dom3; pfam13363 649831011223 Beta-galactosidase jelly roll domain; Region: BetaGal_dom4_5; pfam13364 649831011224 Beta-galactosidase jelly roll domain; Region: BetaGal_dom4_5; pfam13364 649831011225 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 649831011226 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 649831011227 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 649831011228 metal binding site [ion binding]; metal-binding site 649831011229 ligand binding site [chemical binding]; other site 649831011230 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 649831011231 Catalytic domain of Protein Kinases; Region: PKc; cd00180 649831011232 active site 649831011233 ATP binding site [chemical binding]; other site 649831011234 substrate binding site [chemical binding]; other site 649831011235 activation loop (A-loop); other site 649831011236 Nicotinamide mononucleotide transporter [Coenzyme metabolism]; Region: PnuC; COG3201 649831011237 AAA domain; Region: AAA_17; pfam13207 649831011238 Transcriptional regulator [Transcription]; Region: LysR; COG0583 649831011239 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 649831011240 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 649831011241 putative dimerization interface [polypeptide binding]; other site 649831011242 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 649831011243 homotrimer interaction site [polypeptide binding]; other site 649831011244 putative active site [active] 649831011245 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 649831011246 Catalytic domain of Protein Kinases; Region: PKc; cd00180 649831011247 active site 649831011248 ATP binding site [chemical binding]; other site 649831011249 substrate binding site [chemical binding]; other site 649831011250 activation loop (A-loop); other site 649831011251 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 649831011252 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 649831011253 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 649831011254 active site 649831011255 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 649831011256 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 649831011257 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831011258 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 649831011259 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 649831011260 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 649831011261 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 649831011262 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 649831011263 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 649831011264 classical (c) SDRs; Region: SDR_c; cd05233 649831011265 NAD(P) binding site [chemical binding]; other site 649831011266 active site 649831011267 RNA polymerase sigma-70 factor, Planctomycetaceae-specific subfamily 1; Region: Sig-70_plancto1; TIGR02984 649831011268 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 649831011269 dimerization interface [polypeptide binding]; other site 649831011270 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase); Region: GlcNAc_2-epim; pfam07221 649831011271 putative active cleft [active] 649831011272 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 649831011273 heme-binding site [chemical binding]; other site 649831011274 Nitric oxide synthase (NOS) produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N(omega)-hydroxy-L-arginine (NHA) as an...; Region: NOS_oxygenase; cd00575 649831011275 active site 649831011276 dimer interface [polypeptide binding]; other site 649831011277 Predicted transcriptional regulators [Transcription]; Region: COG1725 649831011278 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 649831011279 DNA-binding site [nucleotide binding]; DNA binding site 649831011280 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 649831011281 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 649831011282 Walker A/P-loop; other site 649831011283 ATP binding site [chemical binding]; other site 649831011284 Q-loop/lid; other site 649831011285 ABC transporter signature motif; other site 649831011286 Walker B; other site 649831011287 D-loop; other site 649831011288 H-loop/switch region; other site 649831011289 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 649831011290 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases [Inorganic ion transport and metabolism / General function prediction only]; Region: {NirD}; COG2146 649831011291 iron-sulfur cluster [ion binding]; other site 649831011292 [2Fe-2S] cluster binding site [ion binding]; other site 649831011293 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 649831011294 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 649831011295 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 649831011296 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 649831011297 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 649831011298 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 649831011299 [4Fe-4S] binding site [ion binding]; other site 649831011300 molybdopterin cofactor binding site; other site 649831011301 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 649831011302 molybdopterin cofactor binding site; other site 649831011303 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 649831011304 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 649831011305 putative active site [active] 649831011306 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 649831011307 putative active site [active] 649831011308 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 649831011309 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 649831011310 active site 649831011311 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 649831011312 DNA binding site [nucleotide binding] 649831011313 Glycoside hydrolase family 44; Region: Glyco_hydro_44; pfam12891 649831011314 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 649831011315 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 649831011316 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 649831011317 ATP binding site [chemical binding]; other site 649831011318 Mg2+ binding site [ion binding]; other site 649831011319 G-X-G motif; other site 649831011320 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 649831011321 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 649831011322 homodimer interface [polypeptide binding]; other site 649831011323 pyridoxal 5'-phosphate binding site [chemical binding]; other site 649831011324 catalytic residue [active] 649831011325 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 649831011326 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 649831011327 putative dimer interface [polypeptide binding]; other site 649831011328 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 649831011329 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 649831011330 metal binding site [ion binding]; metal-binding site 649831011331 active site 649831011332 I-site; other site 649831011333 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 649831011334 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 649831011335 tetramer interface [polypeptide binding]; other site 649831011336 pyridoxal 5'-phosphate binding site [chemical binding]; other site 649831011337 catalytic residue [active] 649831011338 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 649831011339 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 649831011340 acyl-activating enzyme (AAE) consensus motif; other site 649831011341 acyl-activating enzyme (AAE) consensus motif; other site 649831011342 AMP binding site [chemical binding]; other site 649831011343 active site 649831011344 CoA binding site [chemical binding]; other site 649831011345 Melibiase; Region: Melibiase; pfam02065 649831011346 Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563 649831011347 active site triad [active] 649831011348 thiopurine S-methyltransferase, Se/Te detoxification family; Region: TMPT_Se_Te; TIGR03840 649831011349 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649831011350 S-adenosylmethionine binding site [chemical binding]; other site 649831011351 Transposase; Region: DEDD_Tnp_IS110; pfam01548 649831011352 Transcriptional regulators [Transcription]; Region: PurR; COG1609 649831011353 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 649831011354 DNA binding site [nucleotide binding] 649831011355 domain linker motif; other site 649831011356 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 649831011357 ligand binding site [chemical binding]; other site 649831011358 dimerization interface [polypeptide binding]; other site 649831011359 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 649831011360 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 649831011361 Protein of unknown function (DUF993); Region: DUF993; pfam06187 649831011362 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 649831011363 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 649831011364 Hemerythrin-like domain; Region: Hr-like; cd12108 649831011365 Fe binding site [ion binding]; other site 649831011366 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 649831011367 Leucine carboxyl methyltransferase; Region: LCM; cl01306 649831011368 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 649831011369 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831011370 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 649831011371 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 649831011372 PAS fold; Region: PAS_3; pfam08447 649831011373 putative active site [active] 649831011374 heme pocket [chemical binding]; other site 649831011375 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 649831011376 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 649831011377 putative CheW interface [polypeptide binding]; other site 649831011378 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 649831011379 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 649831011380 active site 649831011381 catalytic tetrad [active] 649831011382 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 649831011383 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 649831011384 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 649831011385 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649831011386 dimer interface [polypeptide binding]; other site 649831011387 conserved gate region; other site 649831011388 putative PBP binding loops; other site 649831011389 ABC-ATPase subunit interface; other site 649831011390 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 649831011391 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649831011392 Walker A/P-loop; other site 649831011393 ATP binding site [chemical binding]; other site 649831011394 Q-loop/lid; other site 649831011395 ABC transporter signature motif; other site 649831011396 Walker B; other site 649831011397 D-loop; other site 649831011398 H-loop/switch region; other site 649831011399 TOBE domain; Region: TOBE_2; pfam08402 649831011400 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 649831011401 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 649831011402 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 649831011403 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 649831011404 active site 649831011405 catalytic triad [active] 649831011406 oxyanion hole [active] 649831011407 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 649831011408 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 649831011409 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 649831011410 non-specific DNA binding site [nucleotide binding]; other site 649831011411 salt bridge; other site 649831011412 sequence-specific DNA binding site [nucleotide binding]; other site 649831011413 Domain of unknown function (DUF397); Region: DUF397; pfam04149 649831011414 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 649831011415 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 649831011416 active site 649831011417 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 649831011418 dimer interface [polypeptide binding]; other site 649831011419 catalytic residues [active] 649831011420 substrate binding site [chemical binding]; other site 649831011421 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 649831011422 NMT1/THI5 like; Region: NMT1; pfam09084 649831011423 substrate binding pocket [chemical binding]; other site 649831011424 membrane-bound complex binding site; other site 649831011425 hinge residues; other site 649831011426 Menaquinone biosynthesis; Region: VitK2_biosynth; cl17475 649831011427 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 649831011428 MarR family; Region: MarR; pfam01047 649831011429 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 649831011430 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 649831011431 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 649831011432 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649831011433 Walker A/P-loop; other site 649831011434 ATP binding site [chemical binding]; other site 649831011435 Q-loop/lid; other site 649831011436 ABC transporter signature motif; other site 649831011437 Walker B; other site 649831011438 D-loop; other site 649831011439 H-loop/switch region; other site 649831011440 TOBE domain; Region: TOBE_2; pfam08402 649831011441 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 649831011442 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 649831011443 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649831011444 dimer interface [polypeptide binding]; other site 649831011445 conserved gate region; other site 649831011446 putative PBP binding loops; other site 649831011447 ABC-ATPase subunit interface; other site 649831011448 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 649831011449 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649831011450 dimer interface [polypeptide binding]; other site 649831011451 conserved gate region; other site 649831011452 putative PBP binding loops; other site 649831011453 ABC-ATPase subunit interface; other site 649831011454 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 649831011455 FAD dependent oxidoreductase; Region: DAO; pfam01266 649831011456 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 649831011457 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 649831011458 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 649831011459 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 649831011460 hypothetical protein; Provisional; Region: PRK06541 649831011461 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 649831011462 inhibitor-cofactor binding pocket; inhibition site 649831011463 pyridoxal 5'-phosphate binding site [chemical binding]; other site 649831011464 catalytic residue [active] 649831011465 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 649831011466 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 649831011467 putative DNA binding site [nucleotide binding]; other site 649831011468 putative Zn2+ binding site [ion binding]; other site 649831011469 AsnC family; Region: AsnC_trans_reg; pfam01037 649831011470 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 649831011471 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 649831011472 Walker A/P-loop; other site 649831011473 ATP binding site [chemical binding]; other site 649831011474 Q-loop/lid; other site 649831011475 ABC transporter signature motif; other site 649831011476 Walker B; other site 649831011477 D-loop; other site 649831011478 H-loop/switch region; other site 649831011479 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 649831011480 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 649831011481 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 649831011482 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 649831011483 inhibitor-cofactor binding pocket; inhibition site 649831011484 pyridoxal 5'-phosphate binding site [chemical binding]; other site 649831011485 catalytic residue [active] 649831011486 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 649831011487 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 649831011488 tetrameric interface [polypeptide binding]; other site 649831011489 NAD binding site [chemical binding]; other site 649831011490 catalytic residues [active] 649831011491 substrate binding site [chemical binding]; other site 649831011492 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831011493 WHG domain; Region: WHG; pfam13305 649831011494 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 649831011495 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 649831011496 5'-3' exonuclease; Region: 53EXOc; smart00475 649831011497 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 649831011498 active site 649831011499 metal binding site 1 [ion binding]; metal-binding site 649831011500 putative 5' ssDNA interaction site; other site 649831011501 metal binding site 3; metal-binding site 649831011502 metal binding site 2 [ion binding]; metal-binding site 649831011503 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 649831011504 putative DNA binding site [nucleotide binding]; other site 649831011505 putative metal binding site [ion binding]; other site 649831011506 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 649831011507 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 649831011508 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 649831011509 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 649831011510 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 649831011511 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 649831011512 FeS/SAM binding site; other site 649831011513 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 649831011514 TfuA-like protein; Region: TfuA; pfam07812 649831011515 Uncharacterized conserved protein [Function unknown]; Region: COG1944 649831011516 YcaO-like family; Region: YcaO; pfam02624 649831011517 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 649831011518 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649831011519 Walker A/P-loop; other site 649831011520 ATP binding site [chemical binding]; other site 649831011521 Q-loop/lid; other site 649831011522 ABC transporter signature motif; other site 649831011523 Walker B; other site 649831011524 D-loop; other site 649831011525 H-loop/switch region; other site 649831011526 ATP-grasp ribosomal peptide maturase, SAV_5884 family; Region: GRASP_SAV_5884; TIGR04187 649831011527 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 649831011528 DNA binding residues [nucleotide binding] 649831011529 dimerization interface [polypeptide binding]; other site 649831011530 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 649831011531 cyclase homology domain; Region: CHD; cd07302 649831011532 nucleotidyl binding site; other site 649831011533 dimer interface [polypeptide binding]; other site 649831011534 metal binding site [ion binding]; metal-binding site 649831011535 Predicted ATPase [General function prediction only]; Region: COG3899 649831011536 AAA ATPase domain; Region: AAA_16; pfam13191 649831011537 Peptidase S8 family domain, uncharacterized subfamily 8; Region: Peptidases_S8_8; cd07492 649831011538 active site 649831011539 catalytic triad [active] 649831011540 GAF domain; Region: GAF; pfam01590 649831011541 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 649831011542 non-specific DNA binding site [nucleotide binding]; other site 649831011543 salt bridge; other site 649831011544 sequence-specific DNA binding site [nucleotide binding]; other site 649831011545 AAA ATPase domain; Region: AAA_16; pfam13191 649831011546 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 649831011547 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 649831011548 FeS/SAM binding site; other site 649831011549 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 649831011550 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251 649831011551 Helix-turn-helix domain; Region: HTH_20; pfam12840 649831011552 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 649831011553 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 649831011554 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 649831011555 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 649831011556 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 649831011557 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 649831011558 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 649831011559 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 649831011560 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 649831011561 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831011562 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 649831011563 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 649831011564 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 649831011565 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 649831011566 metal binding site [ion binding]; metal-binding site 649831011567 active site 649831011568 I-site; other site 649831011569 PAS domain S-box; Region: sensory_box; TIGR00229 649831011570 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 649831011571 putative active site [active] 649831011572 heme pocket [chemical binding]; other site 649831011573 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 649831011574 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 649831011575 dimer interface [polypeptide binding]; other site 649831011576 phosphorylation site [posttranslational modification] 649831011577 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831011578 ATP binding site [chemical binding]; other site 649831011579 Mg2+ binding site [ion binding]; other site 649831011580 G-X-G motif; other site 649831011581 Response regulator receiver domain; Region: Response_reg; pfam00072 649831011582 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831011583 active site 649831011584 phosphorylation site [posttranslational modification] 649831011585 intermolecular recognition site; other site 649831011586 dimerization interface [polypeptide binding]; other site 649831011587 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 649831011588 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 649831011589 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 649831011590 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 649831011591 metal ion-dependent adhesion site (MIDAS); other site 649831011592 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649831011593 Walker A/P-loop; other site 649831011594 ATP binding site [chemical binding]; other site 649831011595 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 649831011596 metal binding site [ion binding]; metal-binding site 649831011597 active site 649831011598 Cellulose binding domain; Region: CBM_2; pfam00553 649831011599 SGNH_hydrolase subfamily, similar to Ruminococcus flavefaciens XynB. Most likely a secreted hydrolase with xylanase activity. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from...; Region: XynB_like; cd01833 649831011600 active site 649831011601 catalytic triad [active] 649831011602 oxyanion hole [active] 649831011603 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 649831011604 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 649831011605 XdhC Rossmann domain; Region: XdhC_C; pfam13478 649831011606 Transcriptional regulators [Transcription]; Region: GntR; COG1802 649831011607 FCD domain; Region: FCD; pfam07729 649831011608 NMT1/THI5 like; Region: NMT1; pfam09084 649831011609 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 649831011610 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 649831011611 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649831011612 putative PBP binding loops; other site 649831011613 dimer interface [polypeptide binding]; other site 649831011614 ABC-ATPase subunit interface; other site 649831011615 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 649831011616 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 649831011617 Walker A/P-loop; other site 649831011618 ATP binding site [chemical binding]; other site 649831011619 Q-loop/lid; other site 649831011620 ABC transporter signature motif; other site 649831011621 Walker B; other site 649831011622 D-loop; other site 649831011623 H-loop/switch region; other site 649831011624 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 649831011625 non-specific DNA binding site [nucleotide binding]; other site 649831011626 salt bridge; other site 649831011627 sequence-specific DNA binding site [nucleotide binding]; other site 649831011628 SnoaL-like domain; Region: SnoaL_2; pfam12680 649831011629 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 649831011630 PQQ-like domain; Region: PQQ_2; pfam13360 649831011631 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 649831011632 Trp docking motif [polypeptide binding]; other site 649831011633 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 649831011634 DNA-binding site [nucleotide binding]; DNA binding site 649831011635 RNA-binding motif; other site 649831011636 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 649831011637 Uncharacterized conserved protein [Function unknown]; Region: COG3595 649831011638 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 649831011639 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649831011640 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 649831011641 Walker A/P-loop; other site 649831011642 ATP binding site [chemical binding]; other site 649831011643 Q-loop/lid; other site 649831011644 ABC transporter signature motif; other site 649831011645 Walker B; other site 649831011646 D-loop; other site 649831011647 H-loop/switch region; other site 649831011648 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 649831011649 ABC-2 type transporter; Region: ABC2_membrane; cl17235 649831011650 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 649831011651 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 649831011652 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 649831011653 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831011654 NAD(P) binding site [chemical binding]; other site 649831011655 active site 649831011656 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649831011657 S-adenosylmethionine binding site [chemical binding]; other site 649831011658 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 649831011659 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 649831011660 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 649831011661 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 649831011662 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 649831011663 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 649831011664 putative sugar binding sites [chemical binding]; other site 649831011665 Q-X-W motif; other site 649831011666 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 649831011667 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 649831011668 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 649831011669 ABC-ATPase subunit interface; other site 649831011670 dimer interface [polypeptide binding]; other site 649831011671 putative PBP binding regions; other site 649831011672 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 649831011673 intersubunit interface [polypeptide binding]; other site 649831011674 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 649831011675 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 649831011676 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 649831011677 Walker A/P-loop; other site 649831011678 ATP binding site [chemical binding]; other site 649831011679 Q-loop/lid; other site 649831011680 ABC transporter signature motif; other site 649831011681 Walker B; other site 649831011682 D-loop; other site 649831011683 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 649831011684 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831011685 WHG domain; Region: WHG; pfam13305 649831011686 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 649831011687 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 649831011688 putative acyl-acceptor binding pocket; other site 649831011689 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 649831011690 salt bridge; other site 649831011691 non-specific DNA binding site [nucleotide binding]; other site 649831011692 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 649831011693 sequence-specific DNA binding site [nucleotide binding]; other site 649831011694 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 649831011695 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 649831011696 active site 649831011697 catalytic tetrad [active] 649831011698 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 649831011699 MOSC domain; Region: MOSC; pfam03473 649831011700 Predicted acetyltransferase [General function prediction only]; Region: COG3153 649831011701 Amino acid permease; Region: AA_permease_2; pfam13520 649831011702 Uncharacterized conserved protein [Function unknown]; Region: COG3268 649831011703 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831011704 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 649831011705 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 649831011706 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 649831011707 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 649831011708 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 649831011709 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cl00942 649831011710 aromatic arch; other site 649831011711 DCoH dimer interaction site [polypeptide binding]; other site 649831011712 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 649831011713 DCoH tetramer interaction site [polypeptide binding]; other site 649831011714 substrate binding site [chemical binding]; other site 649831011715 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 649831011716 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 649831011717 hydrophobic ligand binding site; other site 649831011718 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 649831011719 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 649831011720 tetramer interface [polypeptide binding]; other site 649831011721 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 649831011722 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 649831011723 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 649831011724 His-Xaa-Ser system radical SAM maturase HxsC; Region: rSAM_pair_HxsC; TIGR03977 649831011725 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 649831011726 FeS/SAM binding site; other site 649831011727 His-Xaa-Ser system radical SAM maturase HxsB; Region: rSAM_paired_1; TIGR03978 649831011728 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 649831011729 FeS/SAM binding site; other site 649831011730 His-Xaa-Ser system protein HsxD; Region: chp_LLNDYxLRE; TIGR03976 649831011731 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 649831011732 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 649831011733 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 649831011734 hydrophobic ligand binding site; other site 649831011735 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 649831011736 active site 649831011737 catalytic motif [active] 649831011738 Zn binding site [ion binding]; other site 649831011739 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 649831011740 MMPL family; Region: MMPL; pfam03176 649831011741 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 649831011742 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831011743 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 649831011744 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 649831011745 active site 649831011746 I-site; other site 649831011747 metal binding site [ion binding]; metal-binding site 649831011748 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 649831011749 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 649831011750 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 649831011751 N-acetyl-D-glucosamine binding site [chemical binding]; other site 649831011752 catalytic residue [active] 649831011753 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 649831011754 DNA-binding site [nucleotide binding]; DNA binding site 649831011755 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 649831011756 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 649831011757 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 649831011758 adenosine deaminase; Provisional; Region: PRK09358 649831011759 active site 649831011760 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 649831011761 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 649831011762 putative ligand binding site [chemical binding]; other site 649831011763 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 649831011764 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 649831011765 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 649831011766 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 649831011767 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 649831011768 putative ADP-binding pocket [chemical binding]; other site 649831011769 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 649831011770 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 649831011771 Transglycosylase; Region: Transgly; pfam00912 649831011772 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 649831011773 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 649831011774 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 649831011775 Catalytic domain of Protein Kinases; Region: PKc; cd00180 649831011776 active site 649831011777 ATP binding site [chemical binding]; other site 649831011778 substrate binding site [chemical binding]; other site 649831011779 activation loop (A-loop); other site 649831011780 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 649831011781 active site 649831011782 catalytic triad [active] 649831011783 oxyanion hole [active] 649831011784 PAS fold; Region: PAS_4; pfam08448 649831011785 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 649831011786 putative active site [active] 649831011787 heme pocket [chemical binding]; other site 649831011788 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 649831011789 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 649831011790 metal binding site [ion binding]; metal-binding site 649831011791 active site 649831011792 I-site; other site 649831011793 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 649831011794 Acyltransferase family; Region: Acyl_transf_3; pfam01757 649831011795 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 649831011796 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 649831011797 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 649831011798 conserved cys residue [active] 649831011799 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 649831011800 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 649831011801 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 649831011802 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 649831011803 active site 649831011804 metal binding site [ion binding]; metal-binding site 649831011805 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 649831011806 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 649831011807 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 649831011808 DNA binding residues [nucleotide binding] 649831011809 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 649831011810 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 649831011811 metal binding site [ion binding]; metal-binding site 649831011812 active site 649831011813 I-site; other site 649831011814 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 649831011815 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 649831011816 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 649831011817 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12854 649831011818 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 649831011819 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 649831011820 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 649831011821 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 649831011822 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 649831011823 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831011824 ATP binding site [chemical binding]; other site 649831011825 Mg2+ binding site [ion binding]; other site 649831011826 G-X-G motif; other site 649831011827 MOSC domain; Region: MOSC; pfam03473 649831011828 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 649831011829 Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270 649831011830 Cellulose binding domain; Region: CBM_2; pfam00553 649831011831 Glycosyl hydrolase family 48; Region: Glyco_hydro_48; pfam02011 649831011832 Sensors of blue-light using FAD; Region: BLUF; pfam04940 649831011833 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 649831011834 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 649831011835 DNA binding residues [nucleotide binding] 649831011836 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 649831011837 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 649831011838 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 649831011839 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 649831011840 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 649831011841 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 649831011842 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 649831011843 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649831011844 dimer interface [polypeptide binding]; other site 649831011845 conserved gate region; other site 649831011846 putative PBP binding loops; other site 649831011847 ABC-ATPase subunit interface; other site 649831011848 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 649831011849 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 649831011850 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649831011851 dimer interface [polypeptide binding]; other site 649831011852 conserved gate region; other site 649831011853 putative PBP binding loops; other site 649831011854 ABC-ATPase subunit interface; other site 649831011855 Transcriptional regulators [Transcription]; Region: PurR; COG1609 649831011856 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 649831011857 DNA binding site [nucleotide binding] 649831011858 domain linker motif; other site 649831011859 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 649831011860 ligand binding site [chemical binding]; other site 649831011861 dimerization interface (open form) [polypeptide binding]; other site 649831011862 dimerization interface (closed form) [polypeptide binding]; other site 649831011863 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 649831011864 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 649831011865 Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; cl17492 649831011866 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 649831011867 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 649831011868 active site 649831011869 octamer interface [polypeptide binding]; other site 649831011870 Uncharacterized conserved protein [Function unknown]; Region: COG3375 649831011871 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 649831011872 Catalytic domain of Protein Kinases; Region: PKc; cd00180 649831011873 active site 649831011874 ATP binding site [chemical binding]; other site 649831011875 substrate binding site [chemical binding]; other site 649831011876 activation loop (A-loop); other site 649831011877 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 649831011878 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 649831011879 putative sugar binding sites [chemical binding]; other site 649831011880 Q-X-W motif; other site 649831011881 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 649831011882 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 649831011883 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 649831011884 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 649831011885 catalytic residues [active] 649831011886 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 649831011887 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 649831011888 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 649831011889 dimer interface [polypeptide binding]; other site 649831011890 putative functional site; other site 649831011891 putative MPT binding site; other site 649831011892 hypothetical protein; Provisional; Region: PRK07236 649831011893 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 649831011894 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 649831011895 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 649831011896 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831011897 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 649831011898 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 649831011899 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 649831011900 DNA binding site [nucleotide binding] 649831011901 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 649831011902 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 649831011903 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 649831011904 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 649831011905 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 649831011906 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 649831011907 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 649831011908 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 649831011909 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 649831011910 substrate binding pocket [chemical binding]; other site 649831011911 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 649831011912 B12 binding site [chemical binding]; other site 649831011913 cobalt ligand [ion binding]; other site 649831011914 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 649831011915 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 649831011916 nucleotide binding site/active site [active] 649831011917 HIT family signature motif; other site 649831011918 catalytic residue [active] 649831011919 Prostaglandin dehydrogenases; Region: PGDH; cd05288 649831011920 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 649831011921 NAD(P) binding site [chemical binding]; other site 649831011922 substrate binding site [chemical binding]; other site 649831011923 dimer interface [polypeptide binding]; other site 649831011924 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649831011925 S-adenosylmethionine binding site [chemical binding]; other site 649831011926 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 649831011927 FOG: WD40 repeat [General function prediction only]; Region: COG2319 649831011928 structural tetrad; other site 649831011929 FOG: WD40 repeat [General function prediction only]; Region: COG2319 649831011930 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 649831011931 structural tetrad; other site 649831011932 Serine hydrolase; Region: Ser_hydrolase; cl17834 649831011933 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 649831011934 heat shock protein 90; Provisional; Region: PRK05218 649831011935 ATP binding site [chemical binding]; other site 649831011936 Mg2+ binding site [ion binding]; other site 649831011937 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 649831011938 G-X-G motif; other site 649831011939 sugar efflux transporter; Region: 2A0120; TIGR00899 649831011940 Putative esterase; Region: Esterase; pfam00756 649831011941 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 649831011942 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 649831011943 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 649831011944 motif II; other site 649831011945 Transcriptional regulator [Transcription]; Region: LysR; COG0583 649831011946 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 649831011947 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 649831011948 dimerization interface [polypeptide binding]; other site 649831011949 substrate binding pocket [chemical binding]; other site 649831011950 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 649831011951 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 649831011952 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 649831011953 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 649831011954 putative NAD(P) binding site [chemical binding]; other site 649831011955 Selenocysteine-specific translation elongation factor [Translation, ribosomal structure and biogenesis]; Region: SelB; COG3276 649831011956 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 649831011957 G1 box; other site 649831011958 putative GEF interaction site [polypeptide binding]; other site 649831011959 GTP/Mg2+ binding site [chemical binding]; other site 649831011960 Switch I region; other site 649831011961 G2 box; other site 649831011962 G3 box; other site 649831011963 Switch II region; other site 649831011964 G4 box; other site 649831011965 G5 box; other site 649831011966 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 649831011967 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 649831011968 selenocysteine synthase; Provisional; Region: PRK04311 649831011969 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 649831011970 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 649831011971 Predicted acetyltransferase [General function prediction only]; Region: COG2388 649831011972 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 649831011973 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 649831011974 heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966 649831011975 phosphate binding site [ion binding]; other site 649831011976 selenophosphate synthetase; Provisional; Region: PRK00943 649831011977 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 649831011978 dimerization interface [polypeptide binding]; other site 649831011979 putative ATP binding site [chemical binding]; other site 649831011980 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 649831011981 dimerization interface [polypeptide binding]; other site 649831011982 active site 649831011983 RibD C-terminal domain; Region: RibD_C; cl17279 649831011984 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 649831011985 Methyltransferase domain; Region: Methyltransf_25; pfam13649 649831011986 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 649831011987 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 649831011988 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 649831011989 active site 649831011990 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 649831011991 putative NAD(P) binding site [chemical binding]; other site 649831011992 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 649831011993 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 649831011994 cobalamin binding residues [chemical binding]; other site 649831011995 putative BtuC binding residues; other site 649831011996 dimer interface [polypeptide binding]; other site 649831011997 Phosphotransferase enzyme family; Region: APH; pfam01636 649831011998 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 649831011999 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 649831012000 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 649831012001 ATP binding site [chemical binding]; other site 649831012002 putative Mg++ binding site [ion binding]; other site 649831012003 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 649831012004 nucleotide binding region [chemical binding]; other site 649831012005 ATP-binding site [chemical binding]; other site 649831012006 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 649831012007 HRDC domain; Region: HRDC; pfam00570 649831012008 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 649831012009 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 649831012010 N-terminal domain interface [polypeptide binding]; other site 649831012011 dimer interface [polypeptide binding]; other site 649831012012 substrate binding pocket (H-site) [chemical binding]; other site 649831012013 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 649831012014 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 649831012015 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 649831012016 YCII-related domain; Region: YCII; cl00999 649831012017 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 649831012018 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 649831012019 dimer interface [polypeptide binding]; other site 649831012020 active site 649831012021 CoA binding pocket [chemical binding]; other site 649831012022 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 649831012023 nucleoside/Zn binding site; other site 649831012024 dimer interface [polypeptide binding]; other site 649831012025 catalytic motif [active] 649831012026 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 649831012027 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831012028 enoyl_reductase_like; Region: enoyl_reductase_like; cd08249 649831012029 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 649831012030 NAD(P) binding site [chemical binding]; other site 649831012031 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 649831012032 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 649831012033 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831012034 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 649831012035 NAD(P) binding site [chemical binding]; other site 649831012036 active site 649831012037 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 649831012038 CGNR zinc finger; Region: zf-CGNR; pfam11706 649831012039 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 649831012040 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 649831012041 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 649831012042 NodB motif; other site 649831012043 active site 649831012044 catalytic site [active] 649831012045 metal binding site [ion binding]; metal-binding site 649831012046 Fungalysin metallopeptidase (M36); Region: Peptidase_M36; pfam02128 649831012047 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 649831012048 Zn binding site [ion binding]; other site 649831012049 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 649831012050 FAD binding domain; Region: FAD_binding_4; pfam01565 649831012051 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 649831012052 FAD binding domain; Region: FAD_binding_4; pfam01565 649831012053 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 649831012054 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 649831012055 Cysteine-rich domain; Region: CCG; pfam02754 649831012056 Cysteine-rich domain; Region: CCG; pfam02754 649831012057 Uncharacterized conserved protein [Function unknown]; Region: COG1359 649831012058 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268 649831012059 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 649831012060 putative NAD(P) binding site [chemical binding]; other site 649831012061 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 649831012062 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 649831012063 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 649831012064 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 649831012065 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 649831012066 SmpB-tmRNA interface; other site 649831012067 hypothetical protein; Provisional; Region: PRK08244 649831012068 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 649831012069 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 649831012070 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 649831012071 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831012072 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 649831012073 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 649831012074 metal binding site [ion binding]; metal-binding site 649831012075 active site 649831012076 I-site; other site 649831012077 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 649831012078 Domain of unknown function (DUF4332); Region: DUF4332; pfam14229 649831012079 short chain dehydrogenase; Provisional; Region: PRK06180 649831012080 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 649831012081 NADP binding site [chemical binding]; other site 649831012082 active site 649831012083 steroid binding site; other site 649831012084 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 649831012085 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 649831012086 salt bridge; other site 649831012087 non-specific DNA binding site [nucleotide binding]; other site 649831012088 sequence-specific DNA binding site [nucleotide binding]; other site 649831012089 ABC-type Co2+ transport system, permease component [Inorganic ion transport and metabolism]; Region: CbiM; COG0310 649831012090 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 649831012091 PDGLE domain; Region: PDGLE; pfam13190 649831012092 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 649831012093 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 649831012094 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 649831012095 Walker A/P-loop; other site 649831012096 ATP binding site [chemical binding]; other site 649831012097 Q-loop/lid; other site 649831012098 ABC transporter signature motif; other site 649831012099 Walker B; other site 649831012100 D-loop; other site 649831012101 H-loop/switch region; other site 649831012102 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 649831012103 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 649831012104 Transcriptional regulators [Transcription]; Region: PurR; COG1609 649831012105 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 649831012106 DNA binding site [nucleotide binding] 649831012107 domain linker motif; other site 649831012108 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 649831012109 dimerization interface [polypeptide binding]; other site 649831012110 ligand binding site [chemical binding]; other site 649831012111 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 649831012112 Thioredoxin; Region: Thioredoxin_4; pfam13462 649831012113 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 649831012114 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 649831012115 anti sigma factor interaction site; other site 649831012116 regulatory phosphorylation site [posttranslational modification]; other site 649831012117 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 649831012118 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 649831012119 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 649831012120 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 649831012121 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 649831012122 Coenzyme A binding pocket [chemical binding]; other site 649831012123 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 649831012124 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 649831012125 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 649831012126 catalytic residues [active] 649831012127 CHAT domain; Region: CHAT; cl17868 649831012128 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 649831012129 active site 649831012130 catalytic residues [active] 649831012131 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 649831012132 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 649831012133 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 649831012134 active site 649831012135 catalytic residues [active] 649831012136 metal binding site [ion binding]; metal-binding site 649831012137 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 649831012138 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 649831012139 metal binding site [ion binding]; metal-binding site 649831012140 active site 649831012141 I-site; other site 649831012142 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 649831012143 GAF domain; Region: GAF; pfam01590 649831012144 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 649831012145 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 649831012146 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 649831012147 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 649831012148 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 649831012149 DNA binding residues [nucleotide binding] 649831012150 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 649831012151 anti sigma factor interaction site; other site 649831012152 regulatory phosphorylation site [posttranslational modification]; other site 649831012153 DAK2 domain; Region: Dak2; cl03685 649831012154 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 649831012155 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 649831012156 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 649831012157 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 649831012158 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 649831012159 Walker A/P-loop; other site 649831012160 ATP binding site [chemical binding]; other site 649831012161 Q-loop/lid; other site 649831012162 ABC transporter signature motif; other site 649831012163 Walker B; other site 649831012164 D-loop; other site 649831012165 H-loop/switch region; other site 649831012166 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 649831012167 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 649831012168 Walker A/P-loop; other site 649831012169 ATP binding site [chemical binding]; other site 649831012170 Q-loop/lid; other site 649831012171 ABC transporter signature motif; other site 649831012172 Walker B; other site 649831012173 D-loop; other site 649831012174 H-loop/switch region; other site 649831012175 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_7; cd12166 649831012176 putative ligand binding site [chemical binding]; other site 649831012177 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 649831012178 putative NAD binding site [chemical binding]; other site 649831012179 catalytic site [active] 649831012180 Transcriptional regulator [Transcription]; Region: LytR; COG1316 649831012181 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 649831012182 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 649831012183 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 649831012184 threonine synthase; Validated; Region: PRK08197 649831012185 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 649831012186 homodimer interface [polypeptide binding]; other site 649831012187 pyridoxal 5'-phosphate binding site [chemical binding]; other site 649831012188 catalytic residue [active] 649831012189 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 649831012190 conserved cys residue [active] 649831012191 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 649831012192 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 649831012193 metal binding site [ion binding]; metal-binding site 649831012194 active site 649831012195 I-site; other site 649831012196 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 649831012197 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 649831012198 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 649831012199 metal binding site [ion binding]; metal-binding site 649831012200 active site 649831012201 I-site; other site 649831012202 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 649831012203 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831012204 putative substrate translocation pore; other site 649831012205 POT family; Region: PTR2; cl17359 649831012206 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831012207 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 649831012208 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 649831012209 putative NAD(P) binding site [chemical binding]; other site 649831012210 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 649831012211 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 649831012212 active site 649831012213 nucleotide binding site [chemical binding]; other site 649831012214 HIGH motif; other site 649831012215 KMSKS motif; other site 649831012216 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 649831012217 N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cl03119 649831012218 DNA binding site [nucleotide binding] 649831012219 catalytic residue [active] 649831012220 H2TH interface [polypeptide binding]; other site 649831012221 putative catalytic residues [active] 649831012222 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 649831012223 CHASE3 domain; Region: CHASE3; pfam05227 649831012224 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 649831012225 dimerization interface [polypeptide binding]; other site 649831012226 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 649831012227 dimer interface [polypeptide binding]; other site 649831012228 phosphorylation site [posttranslational modification] 649831012229 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831012230 ATP binding site [chemical binding]; other site 649831012231 Mg2+ binding site [ion binding]; other site 649831012232 G-X-G motif; other site 649831012233 Transcriptional regulators [Transcription]; Region: PurR; COG1609 649831012234 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 649831012235 DNA binding site [nucleotide binding] 649831012236 domain linker motif; other site 649831012237 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_10; cd06292 649831012238 putative dimerization interface [polypeptide binding]; other site 649831012239 putative ligand binding site [chemical binding]; other site 649831012240 Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_euk_AmyA; cd11317 649831012241 active site 649831012242 Ca binding site [ion binding]; other site 649831012243 catalytic site [active] 649831012244 Aamy_C domain; Region: Aamy_C; smart00632 649831012245 The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cl15347 649831012246 starch-binding site 2 [chemical binding]; other site 649831012247 starch-binding site 1 [chemical binding]; other site 649831012248 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 649831012249 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 649831012250 NAD(P) binding site [chemical binding]; other site 649831012251 catalytic residues [active] 649831012252 phosphoenolpyruvate synthase; Validated; Region: PRK06241 649831012253 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 649831012254 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 649831012255 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 649831012256 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 649831012257 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 649831012258 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 649831012259 DNA binding residues [nucleotide binding] 649831012260 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 649831012261 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 649831012262 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 649831012263 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 649831012264 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831012265 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 649831012266 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831012267 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831012268 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 649831012269 extended (e) SDRs; Region: SDR_e; cd08946 649831012270 NAD(P) binding site [chemical binding]; other site 649831012271 active site 649831012272 substrate binding site [chemical binding]; other site 649831012273 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 649831012274 putative substrate binding site [chemical binding]; other site 649831012275 putative ATP binding site [chemical binding]; other site 649831012276 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 649831012277 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 649831012278 substrate binding site [chemical binding]; other site 649831012279 ATP binding site [chemical binding]; other site 649831012280 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 649831012281 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 649831012282 AhpC/TSA family; Region: AhpC-TSA; pfam00578 649831012283 RibD C-terminal domain; Region: RibD_C; cl17279 649831012284 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 649831012285 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 649831012286 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 649831012287 alpha-galactosidase; Provisional; Region: PRK15076 649831012288 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 649831012289 NAD binding site [chemical binding]; other site 649831012290 sugar binding site [chemical binding]; other site 649831012291 divalent metal binding site [ion binding]; other site 649831012292 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 649831012293 dimer interface [polypeptide binding]; other site 649831012294 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 649831012295 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 649831012296 dimer interface [polypeptide binding]; other site 649831012297 active site 649831012298 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 649831012299 dimer interface [polypeptide binding]; other site 649831012300 active site 649831012301 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 649831012302 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 649831012303 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649831012304 dimer interface [polypeptide binding]; other site 649831012305 conserved gate region; other site 649831012306 putative PBP binding loops; other site 649831012307 ABC-ATPase subunit interface; other site 649831012308 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 649831012309 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649831012310 dimer interface [polypeptide binding]; other site 649831012311 conserved gate region; other site 649831012312 putative PBP binding loops; other site 649831012313 ABC-ATPase subunit interface; other site 649831012314 Cadmium resistance transporter; Region: Cad; pfam03596 649831012315 Cellulose binding domain; Region: CBM_2; pfam00553 649831012316 Glycosyl hydrolase family 62; Region: Glyco_hydro_62; pfam03664 649831012317 active site 649831012318 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 649831012319 putative deacylase active site [active] 649831012320 Domain of unknown function (DUF427); Region: DUF427; pfam04248 649831012321 cell division protein ZipA; Provisional; Region: PRK03427 649831012322 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 649831012323 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 649831012324 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 649831012325 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 649831012326 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 649831012327 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 649831012328 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 649831012329 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 649831012330 DNA binding residues [nucleotide binding] 649831012331 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 649831012332 Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041 649831012333 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 649831012334 dimerization interface [polypeptide binding]; other site 649831012335 putative DNA binding site [nucleotide binding]; other site 649831012336 putative Zn2+ binding site [ion binding]; other site 649831012337 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 649831012338 putative hydrophobic ligand binding site [chemical binding]; other site 649831012339 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 649831012340 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 649831012341 NAD(P) binding site [chemical binding]; other site 649831012342 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 649831012343 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 649831012344 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 649831012345 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 649831012346 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 649831012347 DNA binding residues [nucleotide binding] 649831012348 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 649831012349 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 649831012350 HAMP domain; Region: HAMP; pfam00672 649831012351 dimerization interface [polypeptide binding]; other site 649831012352 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 649831012353 dimer interface [polypeptide binding]; other site 649831012354 phosphorylation site [posttranslational modification] 649831012355 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831012356 ATP binding site [chemical binding]; other site 649831012357 Mg2+ binding site [ion binding]; other site 649831012358 G-X-G motif; other site 649831012359 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 649831012360 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831012361 active site 649831012362 phosphorylation site [posttranslational modification] 649831012363 intermolecular recognition site; other site 649831012364 dimerization interface [polypeptide binding]; other site 649831012365 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 649831012366 DNA binding site [nucleotide binding] 649831012367 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 649831012368 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831012369 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 649831012370 classical (c) SDRs; Region: SDR_c; cd05233 649831012371 NAD(P) binding site [chemical binding]; other site 649831012372 active site 649831012373 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 649831012374 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 649831012375 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 649831012376 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649831012377 Walker A/P-loop; other site 649831012378 ATP binding site [chemical binding]; other site 649831012379 Q-loop/lid; other site 649831012380 ABC transporter signature motif; other site 649831012381 Walker B; other site 649831012382 D-loop; other site 649831012383 H-loop/switch region; other site 649831012384 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 649831012385 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 649831012386 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 649831012387 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 649831012388 classical (c) SDRs; Region: SDR_c; cd05233 649831012389 NAD(P) binding site [chemical binding]; other site 649831012390 active site 649831012391 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 649831012392 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 649831012393 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 649831012394 DNA-binding site [nucleotide binding]; DNA binding site 649831012395 UTRA domain; Region: UTRA; pfam07702 649831012396 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 649831012397 substrate binding site [chemical binding]; other site 649831012398 active site 649831012399 catalytic residues [active] 649831012400 heterodimer interface [polypeptide binding]; other site 649831012401 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 649831012402 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 649831012403 pyridoxal 5'-phosphate binding site [chemical binding]; other site 649831012404 catalytic residue [active] 649831012405 SGNH_hydrolase subfamily, similar to Ruminococcus flavefaciens XynB. Most likely a secreted hydrolase with xylanase activity. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from...; Region: XynB_like; cd01833 649831012406 active site 649831012407 catalytic triad [active] 649831012408 oxyanion hole [active] 649831012409 PAS domain S-box; Region: sensory_box; TIGR00229 649831012410 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 649831012411 putative active site [active] 649831012412 heme pocket [chemical binding]; other site 649831012413 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 649831012414 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 649831012415 metal binding site [ion binding]; metal-binding site 649831012416 active site 649831012417 I-site; other site 649831012418 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 649831012419 NlpC/P60 family; Region: NLPC_P60; pfam00877 649831012420 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 649831012421 Penicillinase repressor; Region: Pencillinase_R; pfam03965 649831012422 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 649831012423 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 649831012424 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 649831012425 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 649831012426 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649831012427 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 649831012428 Walker A/P-loop; other site 649831012429 ATP binding site [chemical binding]; other site 649831012430 Q-loop/lid; other site 649831012431 ABC transporter signature motif; other site 649831012432 Walker B; other site 649831012433 D-loop; other site 649831012434 H-loop/switch region; other site 649831012435 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 649831012436 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649831012437 Walker A/P-loop; other site 649831012438 ATP binding site [chemical binding]; other site 649831012439 Q-loop/lid; other site 649831012440 ABC transporter signature motif; other site 649831012441 Walker B; other site 649831012442 D-loop; other site 649831012443 H-loop/switch region; other site 649831012444 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 649831012445 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 649831012446 motif II; other site 649831012447 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 649831012448 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 649831012449 metal binding site [ion binding]; metal-binding site 649831012450 active site 649831012451 I-site; other site 649831012452 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 649831012453 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 649831012454 Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028 649831012455 active site 649831012456 DNA binding site [nucleotide binding] 649831012457 Int/Topo IB signature motif; other site 649831012458 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 649831012459 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 649831012460 putative active site [active] 649831012461 classical (c) SDRs; Region: SDR_c; cd05233 649831012462 NAD(P) binding site [chemical binding]; other site 649831012463 active site 649831012464 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 649831012465 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 649831012466 active site 649831012467 HIGH motif; other site 649831012468 nucleotide binding site [chemical binding]; other site 649831012469 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 649831012470 dimer interface [polypeptide binding]; other site 649831012471 active site 649831012472 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 649831012473 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 649831012474 putative ADP-binding pocket [chemical binding]; other site 649831012475 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 649831012476 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 649831012477 active site 649831012478 motif I; other site 649831012479 motif II; other site 649831012480 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 649831012481 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 649831012482 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 649831012483 putative active site [active] 649831012484 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 649831012485 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 649831012486 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 649831012487 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 649831012488 NAD(P) binding site [chemical binding]; other site 649831012489 catalytic residues [active] 649831012490 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 649831012491 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 649831012492 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 649831012493 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 649831012494 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 649831012495 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 649831012496 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 649831012497 active site 649831012498 catalytic tetrad [active] 649831012499 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 649831012500 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 649831012501 sequence-specific DNA binding site [nucleotide binding]; other site 649831012502 salt bridge; other site 649831012503 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 649831012504 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831012505 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831012506 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 649831012507 dihydropteroate synthase; Region: DHPS; TIGR01496 649831012508 substrate binding pocket [chemical binding]; other site 649831012509 dimer interface [polypeptide binding]; other site 649831012510 inhibitor binding site; inhibition site 649831012511 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 649831012512 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649831012513 Walker A/P-loop; other site 649831012514 ATP binding site [chemical binding]; other site 649831012515 Q-loop/lid; other site 649831012516 ABC transporter signature motif; other site 649831012517 Walker B; other site 649831012518 D-loop; other site 649831012519 H-loop/switch region; other site 649831012520 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 649831012521 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 649831012522 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649831012523 Walker A/P-loop; other site 649831012524 ATP binding site [chemical binding]; other site 649831012525 Q-loop/lid; other site 649831012526 ABC transporter signature motif; other site 649831012527 Walker B; other site 649831012528 D-loop; other site 649831012529 H-loop/switch region; other site 649831012530 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 649831012531 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 649831012532 Transcriptional regulators [Transcription]; Region: PurR; COG1609 649831012533 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 649831012534 DNA binding site [nucleotide binding] 649831012535 domain linker motif; other site 649831012536 Ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation; Region: PBP1_CatR_like; cd06296 649831012537 putative dimerization interface [polypeptide binding]; other site 649831012538 putative ligand binding site [chemical binding]; other site 649831012539 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; pfam04734 649831012540 Transcriptional regulator [Transcription]; Region: LysR; COG0583 649831012541 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 649831012542 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 649831012543 dimerization interface [polypeptide binding]; other site 649831012544 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 649831012545 substrate binding pocket [chemical binding]; other site 649831012546 active site 649831012547 iron coordination sites [ion binding]; other site 649831012548 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 649831012549 nucleotide binding site [chemical binding]; other site 649831012550 substrate binding site [chemical binding]; other site 649831012551 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 649831012552 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 649831012553 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 649831012554 EamA-like transporter family; Region: EamA; pfam00892 649831012555 EamA-like transporter family; Region: EamA; pfam00892 649831012556 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 649831012557 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 649831012558 substrate binding pocket [chemical binding]; other site 649831012559 membrane-bound complex binding site; other site 649831012560 hinge residues; other site 649831012561 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 649831012562 B12 binding site [chemical binding]; other site 649831012563 Coenzyme B12-dependent glutamate mutase epsilon subunit-like family; contains proteins similar to Clostridium cochlearium glutamate mutase (Glm) and Streptomyces tendae Tu901 NikV. Glm catalyzes a carbon-skeleton rearrangement of L-glutamate to...; Region: Glm_e; cl02025 649831012564 substrate binding site [chemical binding]; other site 649831012565 B12 cofactor binding site [chemical binding]; other site 649831012566 heterodimer (sigma-epsilon) interface [polypeptide binding]; other site 649831012567 homodimer (epsilon-epsilon) interface [polypeptide binding]; other site 649831012568 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 649831012569 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831012570 active site 649831012571 phosphorylation site [posttranslational modification] 649831012572 intermolecular recognition site; other site 649831012573 dimerization interface [polypeptide binding]; other site 649831012574 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 649831012575 DNA binding site [nucleotide binding] 649831012576 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 649831012577 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 649831012578 dimerization interface [polypeptide binding]; other site 649831012579 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 649831012580 dimer interface [polypeptide binding]; other site 649831012581 phosphorylation site [posttranslational modification] 649831012582 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831012583 ATP binding site [chemical binding]; other site 649831012584 Mg2+ binding site [ion binding]; other site 649831012585 G-X-G motif; other site 649831012586 MMPL family; Region: MMPL; pfam03176 649831012587 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 649831012588 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 649831012589 DDE superfamily endonuclease; Region: DDE_4; pfam13359 649831012590 Transcriptional regulators [Transcription]; Region: PurR; COG1609 649831012591 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 649831012592 DNA binding site [nucleotide binding] 649831012593 Ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation; Region: PBP1_CatR_like; cd06296 649831012594 putative dimerization interface [polypeptide binding]; other site 649831012595 putative ligand binding site [chemical binding]; other site 649831012596 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 649831012597 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 649831012598 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649831012599 dimer interface [polypeptide binding]; other site 649831012600 conserved gate region; other site 649831012601 putative PBP binding loops; other site 649831012602 ABC-ATPase subunit interface; other site 649831012603 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 649831012604 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649831012605 dimer interface [polypeptide binding]; other site 649831012606 conserved gate region; other site 649831012607 putative PBP binding loops; other site 649831012608 ABC-ATPase subunit interface; other site 649831012609 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 649831012610 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 649831012611 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 649831012612 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 649831012613 FAD binding pocket [chemical binding]; other site 649831012614 FAD binding motif [chemical binding]; other site 649831012615 phosphate binding motif [ion binding]; other site 649831012616 beta-alpha-beta structure motif; other site 649831012617 NAD(p) ribose binding residues [chemical binding]; other site 649831012618 NAD binding pocket [chemical binding]; other site 649831012619 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 649831012620 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 649831012621 catalytic loop [active] 649831012622 iron binding site [ion binding]; other site 649831012623 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 649831012624 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831012625 Domain of unknown function (DUF239); Region: DUF239; pfam03080 649831012626 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 649831012627 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 649831012628 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 649831012629 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 649831012630 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 649831012631 Protein of unknown function (DUF664); Region: DUF664; pfam04978 649831012632 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 649831012633 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 649831012634 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 649831012635 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 649831012636 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831012637 ATP binding site [chemical binding]; other site 649831012638 Mg2+ binding site [ion binding]; other site 649831012639 G-X-G motif; other site 649831012640 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 649831012641 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831012642 active site 649831012643 phosphorylation site [posttranslational modification] 649831012644 intermolecular recognition site; other site 649831012645 dimerization interface [polypeptide binding]; other site 649831012646 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 649831012647 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 649831012648 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 649831012649 Transglycosylase; Region: Transgly; pfam00912 649831012650 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 649831012651 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 649831012652 fructuronate transporter; Provisional; Region: PRK10034; cl15264 649831012653 short chain dehydrogenase; Validated; Region: PRK08264 649831012654 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831012655 NAD(P) binding site [chemical binding]; other site 649831012656 active site 649831012657 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 649831012658 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831012659 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 649831012660 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 649831012661 substrate binding site [chemical binding]; other site 649831012662 ATP binding site [chemical binding]; other site 649831012663 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 649831012664 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649831012665 Walker A/P-loop; other site 649831012666 ATP binding site [chemical binding]; other site 649831012667 Q-loop/lid; other site 649831012668 ABC transporter signature motif; other site 649831012669 Walker B; other site 649831012670 D-loop; other site 649831012671 H-loop/switch region; other site 649831012672 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 649831012673 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 649831012674 Walker A/P-loop; other site 649831012675 ATP binding site [chemical binding]; other site 649831012676 Q-loop/lid; other site 649831012677 ABC transporter signature motif; other site 649831012678 Walker B; other site 649831012679 D-loop; other site 649831012680 H-loop/switch region; other site 649831012681 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 649831012682 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 649831012683 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 649831012684 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 649831012685 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 649831012686 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831012687 active site 649831012688 phosphorylation site [posttranslational modification] 649831012689 intermolecular recognition site; other site 649831012690 dimerization interface [polypeptide binding]; other site 649831012691 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 649831012692 DNA binding site [nucleotide binding] 649831012693 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 649831012694 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 649831012695 dimer interface [polypeptide binding]; other site 649831012696 phosphorylation site [posttranslational modification] 649831012697 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831012698 ATP binding site [chemical binding]; other site 649831012699 Mg2+ binding site [ion binding]; other site 649831012700 G-X-G motif; other site 649831012701 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831012702 active site 649831012703 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 649831012704 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 649831012705 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649831012706 dimer interface [polypeptide binding]; other site 649831012707 conserved gate region; other site 649831012708 putative PBP binding loops; other site 649831012709 ABC-ATPase subunit interface; other site 649831012710 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 649831012711 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649831012712 dimer interface [polypeptide binding]; other site 649831012713 conserved gate region; other site 649831012714 putative PBP binding loops; other site 649831012715 ABC-ATPase subunit interface; other site 649831012716 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 649831012717 Part of AAA domain; Region: AAA_19; pfam13245 649831012718 Family description; Region: UvrD_C_2; pfam13538 649831012719 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 649831012720 homodimer interface [polypeptide binding]; other site 649831012721 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 649831012722 active site pocket [active] 649831012723 The link domain is a hyaluronan (HA)-binding domain. It functions to mediate adhesive interactions during inflammatory leukocyte homing and tumor metastasis. It is found in the CD44 receptor and in human TSG-6. TSG-6 is the protein product of the tumor...; Region: Link_Domain; cl02612 649831012724 hypothetical protein; Provisional; Region: PRK07588 649831012725 hypothetical protein; Provisional; Region: PRK07236 649831012726 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 649831012727 DNA-binding site [nucleotide binding]; DNA binding site 649831012728 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831012729 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 649831012730 CHASE3 domain; Region: CHASE3; pfam05227 649831012731 HAMP domain; Region: HAMP; pfam00672 649831012732 dimerization interface [polypeptide binding]; other site 649831012733 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 649831012734 dimer interface [polypeptide binding]; other site 649831012735 phosphorylation site [posttranslational modification] 649831012736 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831012737 ATP binding site [chemical binding]; other site 649831012738 Mg2+ binding site [ion binding]; other site 649831012739 G-X-G motif; other site 649831012740 GAF domain; Region: GAF; pfam01590 649831012741 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 649831012742 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 649831012743 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 649831012744 dimer interface [polypeptide binding]; other site 649831012745 phosphorylation site [posttranslational modification] 649831012746 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831012747 ATP binding site [chemical binding]; other site 649831012748 Mg2+ binding site [ion binding]; other site 649831012749 G-X-G motif; other site 649831012750 Transcriptional regulators [Transcription]; Region: PurR; COG1609 649831012751 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 649831012752 DNA binding site [nucleotide binding] 649831012753 domain linker motif; other site 649831012754 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 649831012755 ligand binding site [chemical binding]; other site 649831012756 dimerization interface [polypeptide binding]; other site 649831012757 The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506 649831012758 peptide binding site [polypeptide binding]; other site 649831012759 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 649831012760 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 649831012761 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649831012762 dimer interface [polypeptide binding]; other site 649831012763 conserved gate region; other site 649831012764 putative PBP binding loops; other site 649831012765 ABC-ATPase subunit interface; other site 649831012766 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 649831012767 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649831012768 dimer interface [polypeptide binding]; other site 649831012769 conserved gate region; other site 649831012770 putative PBP binding loops; other site 649831012771 ABC-ATPase subunit interface; other site 649831012772 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 649831012773 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 649831012774 Walker A/P-loop; other site 649831012775 ATP binding site [chemical binding]; other site 649831012776 Q-loop/lid; other site 649831012777 ABC transporter signature motif; other site 649831012778 Walker B; other site 649831012779 D-loop; other site 649831012780 H-loop/switch region; other site 649831012781 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 649831012782 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 649831012783 Walker A/P-loop; other site 649831012784 ATP binding site [chemical binding]; other site 649831012785 Q-loop/lid; other site 649831012786 ABC transporter signature motif; other site 649831012787 Walker B; other site 649831012788 D-loop; other site 649831012789 H-loop/switch region; other site 649831012790 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 649831012791 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 649831012792 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 649831012793 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 649831012794 catalytic residue [active] 649831012795 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 649831012796 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 649831012797 Mechanosensitive ion channel; Region: MS_channel; pfam00924 649831012798 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 649831012799 Catalytic domain of Protein Kinases; Region: PKc; cd00180 649831012800 active site 649831012801 ATP binding site [chemical binding]; other site 649831012802 substrate binding site [chemical binding]; other site 649831012803 activation loop (A-loop); other site 649831012804 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 649831012805 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 649831012806 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 649831012807 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 649831012808 Walker A/P-loop; other site 649831012809 ATP binding site [chemical binding]; other site 649831012810 Q-loop/lid; other site 649831012811 ABC transporter signature motif; other site 649831012812 Walker B; other site 649831012813 D-loop; other site 649831012814 H-loop/switch region; other site 649831012815 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 649831012816 taurine ABC transporter, periplasmic binding protein; Region: taurine_ABC_bnd; TIGR01729 649831012817 substrate binding pocket [chemical binding]; other site 649831012818 membrane-bound complex binding site; other site 649831012819 hinge residues; other site 649831012820 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 649831012821 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649831012822 dimer interface [polypeptide binding]; other site 649831012823 conserved gate region; other site 649831012824 putative PBP binding loops; other site 649831012825 ABC-ATPase subunit interface; other site 649831012826 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 649831012827 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 649831012828 hypothetical protein; Provisional; Region: PRK07906 649831012829 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 649831012830 putative metal binding site [ion binding]; other site 649831012831 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 649831012832 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 649831012833 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 649831012834 catalytic residue [active] 649831012835 diaminopimelate epimerase; Region: PLN02536 649831012836 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 649831012837 active site 649831012838 catalytic residues [active] 649831012839 PspC domain; Region: PspC; pfam04024 649831012840 FtsH Extracellular; Region: FtsH_ext; pfam06480 649831012841 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 649831012842 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 649831012843 Walker A motif; other site 649831012844 ATP binding site [chemical binding]; other site 649831012845 Walker B motif; other site 649831012846 arginine finger; other site 649831012847 Peptidase family M41; Region: Peptidase_M41; pfam01434 649831012848 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 649831012849 active site 649831012850 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 649831012851 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 649831012852 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 649831012853 Cellulose binding domain; Region: CBM_2; pfam00553 649831012854 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 649831012855 anti sigma factor interaction site; other site 649831012856 regulatory phosphorylation site [posttranslational modification]; other site 649831012857 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 649831012858 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 649831012859 TAP-like protein; Region: Abhydrolase_4; pfam08386 649831012860 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 649831012861 peptidase domain interface [polypeptide binding]; other site 649831012862 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 649831012863 active site 649831012864 catalytic triad [active] 649831012865 calcium binding site [ion binding]; other site 649831012866 Chitin binding domain; Region: Chitin_bind_3; pfam03067 649831012867 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 649831012868 Zn2+ binding site [ion binding]; other site 649831012869 Mg2+ binding site [ion binding]; other site 649831012870 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 649831012871 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 649831012872 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 649831012873 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 649831012874 Response regulator receiver domain; Region: Response_reg; pfam00072 649831012875 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831012876 active site 649831012877 phosphorylation site [posttranslational modification] 649831012878 intermolecular recognition site; other site 649831012879 dimerization interface [polypeptide binding]; other site 649831012880 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 649831012881 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 649831012882 NAD(P) binding site [chemical binding]; other site 649831012883 Helix-turn-helix domain; Region: HTH_31; pfam13560 649831012884 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 649831012885 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 649831012886 active site 649831012887 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 649831012888 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 649831012889 active site 649831012890 catalytic tetrad [active] 649831012891 Carbohydrate Binding Module 6 (CBM6); appended to glycoside hydrolase (GH) domains, including GH5 (cellulase); Region: CBM6_cellulase-like; cd04080 649831012892 Ca binding site [ion binding]; other site 649831012893 ligand binding site I [chemical binding]; other site 649831012894 homodimer interface [polypeptide binding]; other site 649831012895 ligand binding site II [chemical binding]; other site 649831012896 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 649831012897 prolyl-tRNA synthetase; Provisional; Region: PRK09194 649831012898 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 649831012899 motif 1; other site 649831012900 dimer interface [polypeptide binding]; other site 649831012901 active site 649831012902 motif 2; other site 649831012903 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 649831012904 putative deacylase active site [active] 649831012905 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 649831012906 active site 649831012907 motif 3; other site 649831012908 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 649831012909 anticodon binding site; other site 649831012910 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 649831012911 FOG: CBS domain [General function prediction only]; Region: COG0517 649831012912 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 649831012913 probable non-F420 flavinoid oxidoreductase; Region: flavin_revert; TIGR03885 649831012914 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 649831012915 active site 649831012916 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 649831012917 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 649831012918 active site 649831012919 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649831012920 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831012921 active site 649831012922 phosphorylation site [posttranslational modification] 649831012923 intermolecular recognition site; other site 649831012924 dimerization interface [polypeptide binding]; other site 649831012925 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649831012926 DNA binding residues [nucleotide binding] 649831012927 dimerization interface [polypeptide binding]; other site 649831012928 hypothetical protein; Provisional; Region: PRK07877 649831012929 hypothetical protein; Provisional; Region: PRK07877 649831012930 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 649831012931 GAF domain; Region: GAF; cl17456 649831012932 Histidine kinase; Region: HisKA_3; pfam07730 649831012933 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 649831012934 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 649831012935 Ligand Binding Site [chemical binding]; other site 649831012936 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 649831012937 Cutinase; Region: Cutinase; pfam01083 649831012938 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 649831012939 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 649831012940 putative NAD(P) binding site [chemical binding]; other site 649831012941 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 649831012942 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 649831012943 FAD binding pocket [chemical binding]; other site 649831012944 FAD binding motif [chemical binding]; other site 649831012945 phosphate binding motif [ion binding]; other site 649831012946 beta-alpha-beta structure motif; other site 649831012947 NAD(p) ribose binding residues [chemical binding]; other site 649831012948 NAD binding pocket [chemical binding]; other site 649831012949 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 649831012950 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 649831012951 catalytic loop [active] 649831012952 iron binding site [ion binding]; other site 649831012953 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 649831012954 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 649831012955 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 649831012956 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 649831012957 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 649831012958 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 649831012959 phenylacetic acid degradation protein paaN; Region: PaaN_2; TIGR02288 649831012960 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 649831012961 NAD(P) binding site [chemical binding]; other site 649831012962 catalytic residues [active] 649831012963 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 649831012964 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 649831012965 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831012966 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 649831012967 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 649831012968 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 649831012969 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 649831012970 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 649831012971 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 649831012972 putative dimer interface [polypeptide binding]; other site 649831012973 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 649831012974 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 649831012975 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 649831012976 ligand binding site [chemical binding]; other site 649831012977 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 649831012978 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649831012979 Walker A/P-loop; other site 649831012980 ATP binding site [chemical binding]; other site 649831012981 Q-loop/lid; other site 649831012982 ABC transporter signature motif; other site 649831012983 Walker B; other site 649831012984 D-loop; other site 649831012985 H-loop/switch region; other site 649831012986 Putative sensor; Region: Sensor; pfam13796 649831012987 Histidine kinase; Region: HisKA_3; pfam07730 649831012988 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831012989 ATP binding site [chemical binding]; other site 649831012990 Mg2+ binding site [ion binding]; other site 649831012991 G-X-G motif; other site 649831012992 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649831012993 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831012994 active site 649831012995 phosphorylation site [posttranslational modification] 649831012996 intermolecular recognition site; other site 649831012997 dimerization interface [polypeptide binding]; other site 649831012998 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649831012999 DNA binding residues [nucleotide binding] 649831013000 dimerization interface [polypeptide binding]; other site 649831013001 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 649831013002 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 649831013003 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 649831013004 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 649831013005 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649831013006 Walker A/P-loop; other site 649831013007 ATP binding site [chemical binding]; other site 649831013008 Q-loop/lid; other site 649831013009 ABC transporter signature motif; other site 649831013010 Walker B; other site 649831013011 D-loop; other site 649831013012 H-loop/switch region; other site 649831013013 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 649831013014 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 649831013015 TM-ABC transporter signature motif; other site 649831013016 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 649831013017 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 649831013018 putative ligand binding site [chemical binding]; other site 649831013019 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 649831013020 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 649831013021 tetrameric interface [polypeptide binding]; other site 649831013022 NAD binding site [chemical binding]; other site 649831013023 catalytic residues [active] 649831013024 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 649831013025 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 649831013026 PYR/PP interface [polypeptide binding]; other site 649831013027 dimer interface [polypeptide binding]; other site 649831013028 TPP binding site [chemical binding]; other site 649831013029 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 649831013030 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 649831013031 TPP-binding site; other site 649831013032 KduI/IolB family; Region: KduI; pfam04962 649831013033 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 649831013034 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 649831013035 substrate binding site [chemical binding]; other site 649831013036 ATP binding site [chemical binding]; other site 649831013037 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 649831013038 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 649831013039 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 649831013040 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 649831013041 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 649831013042 putative active site [active] 649831013043 metal binding site [ion binding]; metal-binding site 649831013044 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 649831013045 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 649831013046 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 649831013047 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 649831013048 Coenzyme A binding pocket [chemical binding]; other site 649831013049 Peptidase family M48; Region: Peptidase_M48; cl12018 649831013050 Integral membrane protein TerC family; Region: TerC; cl10468 649831013051 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649831013052 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649831013053 DNA binding residues [nucleotide binding] 649831013054 dimerization interface [polypeptide binding]; other site 649831013055 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 649831013056 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 649831013057 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 649831013058 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 649831013059 FtsX-like permease family; Region: FtsX; pfam02687 649831013060 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 649831013061 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 649831013062 Walker A/P-loop; other site 649831013063 ATP binding site [chemical binding]; other site 649831013064 Q-loop/lid; other site 649831013065 ABC transporter signature motif; other site 649831013066 Walker B; other site 649831013067 D-loop; other site 649831013068 H-loop/switch region; other site 649831013069 HlyD family secretion protein; Region: HlyD_3; pfam13437 649831013070 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 649831013071 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 649831013072 dimerization interface [polypeptide binding]; other site 649831013073 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 649831013074 dimer interface [polypeptide binding]; other site 649831013075 phosphorylation site [posttranslational modification] 649831013076 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831013077 ATP binding site [chemical binding]; other site 649831013078 Mg2+ binding site [ion binding]; other site 649831013079 G-X-G motif; other site 649831013080 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 649831013081 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831013082 active site 649831013083 phosphorylation site [posttranslational modification] 649831013084 intermolecular recognition site; other site 649831013085 dimerization interface [polypeptide binding]; other site 649831013086 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 649831013087 DNA binding site [nucleotide binding] 649831013088 HlyD family secretion protein; Region: HlyD_3; pfam13437 649831013089 acyl-CoA synthetase; Provisional; Region: PRK13390 649831013090 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 649831013091 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649831013092 S-adenosylmethionine binding site [chemical binding]; other site 649831013093 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 649831013094 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 649831013095 L-lactate permease; Region: Lactate_perm; cl00701 649831013096 L-lactate permease; Region: Lactate_perm; cl00701 649831013097 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 649831013098 active site 649831013099 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 649831013100 aromatic chitin/cellulose binding site residues [chemical binding]; other site 649831013101 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 649831013102 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 649831013103 Coenzyme A binding pocket [chemical binding]; other site 649831013104 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 649831013105 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 649831013106 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831013107 putative substrate translocation pore; other site 649831013108 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 649831013109 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 649831013110 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 649831013111 nucleotide binding site [chemical binding]; other site 649831013112 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 649831013113 catalytic core [active] 649831013114 LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037 649831013115 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 649831013116 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 649831013117 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 649831013118 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 649831013119 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 649831013120 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 649831013121 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 649831013122 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 649831013123 active site 649831013124 NNMT/PNMT/TEMT family; Region: NNMT_PNMT_TEMT; pfam01234 649831013125 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 649831013126 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 649831013127 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 649831013128 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 649831013129 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 649831013130 active site 649831013131 dimer interface [polypeptide binding]; other site 649831013132 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 649831013133 dimer interface [polypeptide binding]; other site 649831013134 active site 649831013135 DoxX-like family; Region: DoxX_2; pfam13564 649831013136 MarR family; Region: MarR; pfam01047 649831013137 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 649831013138 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 649831013139 NAD(P) binding site [chemical binding]; other site 649831013140 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 649831013141 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 649831013142 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 649831013143 minor groove reading motif; other site 649831013144 helix-hairpin-helix signature motif; other site 649831013145 active site 649831013146 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 649831013147 FAD binding domain; Region: FAD_binding_2; pfam00890 649831013148 PAS domain S-box; Region: sensory_box; TIGR00229 649831013149 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 649831013150 putative active site [active] 649831013151 heme pocket [chemical binding]; other site 649831013152 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 649831013153 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 649831013154 metal binding site [ion binding]; metal-binding site 649831013155 active site 649831013156 I-site; other site 649831013157 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 649831013158 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 649831013159 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 649831013160 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 649831013161 active site 649831013162 dimer interface [polypeptide binding]; other site 649831013163 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 649831013164 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 649831013165 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 649831013166 TPP-binding site [chemical binding]; other site 649831013167 tetramer interface [polypeptide binding]; other site 649831013168 heterodimer interface [polypeptide binding]; other site 649831013169 phosphorylation loop region [posttranslational modification] 649831013170 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 649831013171 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649831013172 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831013173 active site 649831013174 phosphorylation site [posttranslational modification] 649831013175 intermolecular recognition site; other site 649831013176 dimerization interface [polypeptide binding]; other site 649831013177 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649831013178 DNA binding residues [nucleotide binding] 649831013179 dimerization interface [polypeptide binding]; other site 649831013180 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 649831013181 Histidine kinase; Region: HisKA_3; pfam07730 649831013182 gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522 649831013183 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649831013184 Walker A/P-loop; other site 649831013185 ATP binding site [chemical binding]; other site 649831013186 Q-loop/lid; other site 649831013187 ABC transporter signature motif; other site 649831013188 Walker B; other site 649831013189 D-loop; other site 649831013190 H-loop/switch region; other site 649831013191 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 649831013192 Putative cyclase; Region: Cyclase; cl00814 649831013193 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 649831013194 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 649831013195 Isochorismatase family; Region: Isochorismatase; pfam00857 649831013196 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 649831013197 conserved cis-peptide bond; other site 649831013198 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 649831013199 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 649831013200 MarR family; Region: MarR; pfam01047 649831013201 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 649831013202 DNA binding residues [nucleotide binding] 649831013203 Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699 649831013204 marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788 649831013205 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 649831013206 metal ion-dependent adhesion site (MIDAS); other site 649831013207 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 649831013208 extended (e) SDRs; Region: SDR_e; cd08946 649831013209 active site 649831013210 substrate binding site [chemical binding]; other site 649831013211 putative oxidoreductase/HEAT repeat-containing protein; Provisional; Region: PRK13800 649831013212 putative oxidoreductase/HEAT repeat-containing protein; Provisional; Region: PRK13800 649831013213 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 649831013214 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 649831013215 putative sugar binding sites [chemical binding]; other site 649831013216 Q-X-W motif; other site 649831013217 hypothetical protein; Provisional; Region: PRK11770 649831013218 Domain of unknown function (DUF307); Region: DUF307; pfam03733 649831013219 Domain of unknown function (DUF307); Region: DUF307; pfam03733 649831013220 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 649831013221 Coenzyme A binding pocket [chemical binding]; other site 649831013222 Uncharacterized conserved protein [Function unknown]; Region: COG4279 649831013223 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 649831013224 SNF2 Helicase protein; Region: DUF3670; pfam12419 649831013225 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 649831013226 nucleotide binding region [chemical binding]; other site 649831013227 ATP-binding site [chemical binding]; other site 649831013228 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 649831013229 ATP-grasp domain; Region: ATP-grasp_4; cl17255 649831013230 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 649831013231 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 649831013232 anti sigma factor interaction site; other site 649831013233 regulatory phosphorylation site [posttranslational modification]; other site 649831013234 amino acid transporter; Region: 2A0306; TIGR00909 649831013235 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 649831013236 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 649831013237 Ligand Binding Site [chemical binding]; other site 649831013238 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 649831013239 Ligand Binding Site [chemical binding]; other site 649831013240 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 649831013241 Catalytic domain of Protein Kinases; Region: PKc; cd00180 649831013242 active site 649831013243 ATP binding site [chemical binding]; other site 649831013244 substrate binding site [chemical binding]; other site 649831013245 activation loop (A-loop); other site 649831013246 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 649831013247 active site 649831013248 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 649831013249 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 649831013250 Ligand binding site; other site 649831013251 Putative Catalytic site; other site 649831013252 DXD motif; other site 649831013253 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 649831013254 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 649831013255 active site 649831013256 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 649831013257 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 649831013258 active site 649831013259 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 649831013260 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 649831013261 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 649831013262 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 649831013263 homodimer interface [polypeptide binding]; other site 649831013264 NADP binding site [chemical binding]; other site 649831013265 substrate binding site [chemical binding]; other site 649831013266 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 649831013267 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 649831013268 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 649831013269 short chain dehydrogenase; Provisional; Region: PRK06197 649831013270 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831013271 NAD(P) binding site [chemical binding]; other site 649831013272 active site 649831013273 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 649831013274 Coenzyme A binding pocket [chemical binding]; other site 649831013275 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 649831013276 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 649831013277 G1 box; other site 649831013278 putative GEF interaction site [polypeptide binding]; other site 649831013279 GTP/Mg2+ binding site [chemical binding]; other site 649831013280 Switch I region; other site 649831013281 G2 box; other site 649831013282 G3 box; other site 649831013283 Switch II region; other site 649831013284 G4 box; other site 649831013285 G5 box; other site 649831013286 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 649831013287 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 649831013288 Elongation factor G C-terminus. This domain includes the carboxyl terminal regions of elongation factors (EFs) bacterial EF-G, eukaryotic and archeal EF-2 and eukaryotic mitochondrial mtEFG1s and mtEFG2s. This group also includes proteins similar to the...; Region: Elongation_Factor_C; cl02785 649831013289 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 649831013290 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 649831013291 active site 649831013292 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 649831013293 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 649831013294 putative active site [active] 649831013295 putative metal binding site [ion binding]; other site 649831013296 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 649831013297 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 649831013298 active site 649831013299 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 649831013300 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 649831013301 putative active site [active] 649831013302 putative metal binding site [ion binding]; other site 649831013303 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 649831013304 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 649831013305 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 649831013306 Zn binding site [ion binding]; other site 649831013307 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 649831013308 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 649831013309 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 649831013310 radical SAM protein, MSMEG_0568 family; Region: rSAM_MSMEG_0568; TIGR04043 649831013311 Glycosyl hydrolase family 81; Region: Glyco_hydro_81; cl02310 649831013312 HlyD family secretion protein; Region: HlyD_3; pfam13437 649831013313 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 649831013314 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 649831013315 DXD motif; other site 649831013316 Transcriptional regulators [Transcription]; Region: PurR; COG1609 649831013317 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 649831013318 DNA binding site [nucleotide binding] 649831013319 domain linker motif; other site 649831013320 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 649831013321 putative dimerization interface [polypeptide binding]; other site 649831013322 putative ligand binding site [chemical binding]; other site 649831013323 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 649831013324 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 649831013325 salt bridge; other site 649831013326 non-specific DNA binding site [nucleotide binding]; other site 649831013327 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 649831013328 sequence-specific DNA binding site [nucleotide binding]; other site 649831013329 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 649831013330 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 649831013331 NAD(P) binding site [chemical binding]; other site 649831013332 AAA ATPase domain; Region: AAA_16; pfam13191 649831013333 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649831013334 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649831013335 DNA binding residues [nucleotide binding] 649831013336 dimerization interface [polypeptide binding]; other site 649831013337 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 649831013338 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 649831013339 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 649831013340 dimer interface [polypeptide binding]; other site 649831013341 putative CheW interface [polypeptide binding]; other site 649831013342 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 649831013343 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 649831013344 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649831013345 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 649831013346 Walker A/P-loop; other site 649831013347 ATP binding site [chemical binding]; other site 649831013348 Q-loop/lid; other site 649831013349 ABC transporter signature motif; other site 649831013350 Walker B; other site 649831013351 D-loop; other site 649831013352 H-loop/switch region; other site 649831013353 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 649831013354 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649831013355 Walker A/P-loop; other site 649831013356 ATP binding site [chemical binding]; other site 649831013357 Q-loop/lid; other site 649831013358 ABC transporter signature motif; other site 649831013359 Walker B; other site 649831013360 D-loop; other site 649831013361 H-loop/switch region; other site 649831013362 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 649831013363 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 649831013364 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 649831013365 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 649831013366 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 649831013367 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 649831013368 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 649831013369 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 649831013370 Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564 649831013371 active site 649831013372 Chitin binding domain; Region: Chitin_bind_3; pfam03067 649831013373 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 649831013374 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 649831013375 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649831013376 dimer interface [polypeptide binding]; other site 649831013377 conserved gate region; other site 649831013378 putative PBP binding loops; other site 649831013379 ABC-ATPase subunit interface; other site 649831013380 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 649831013381 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649831013382 putative PBP binding loops; other site 649831013383 ABC-ATPase subunit interface; other site 649831013384 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 649831013385 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 649831013386 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 649831013387 RNA binding surface [nucleotide binding]; other site 649831013388 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 649831013389 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 649831013390 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 649831013391 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 649831013392 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 649831013393 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 649831013394 catalytic triad [active] 649831013395 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 649831013396 anti sigma factor interaction site; other site 649831013397 regulatory phosphorylation site [posttranslational modification]; other site 649831013398 Beta-lactamase; Region: Beta-lactamase; pfam00144 649831013399 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 649831013400 Short C-terminal domain; Region: SHOCT; pfam09851 649831013401 Glycosyl hydrolase family 12; Region: Glyco_hydro_12; cl03302 649831013402 Cellulose binding domain; Region: CBM_2; pfam00553 649831013403 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 649831013404 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 649831013405 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 649831013406 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 649831013407 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 649831013408 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 649831013409 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 649831013410 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 649831013411 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 649831013412 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 649831013413 TM-ABC transporter signature motif; other site 649831013414 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 649831013415 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 649831013416 Walker A/P-loop; other site 649831013417 ATP binding site [chemical binding]; other site 649831013418 Q-loop/lid; other site 649831013419 ABC transporter signature motif; other site 649831013420 Walker B; other site 649831013421 D-loop; other site 649831013422 H-loop/switch region; other site 649831013423 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 649831013424 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 649831013425 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 649831013426 putative ligand binding site [chemical binding]; other site 649831013427 L-arabinose isomerase; Provisional; Region: PRK02929 649831013428 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 649831013429 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 649831013430 trimer interface [polypeptide binding]; other site 649831013431 putative substrate binding site [chemical binding]; other site 649831013432 putative metal binding site [ion binding]; other site 649831013433 L-ribulose-5-phosphate 4-epimerase; Validated; Region: PRK06557 649831013434 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 649831013435 intersubunit interface [polypeptide binding]; other site 649831013436 active site 649831013437 Zn2+ binding site [ion binding]; other site 649831013438 Transcriptional regulators [Transcription]; Region: PurR; COG1609 649831013439 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 649831013440 DNA binding site [nucleotide binding] 649831013441 domain linker motif; other site 649831013442 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 649831013443 ligand binding site [chemical binding]; other site 649831013444 dimerization interface (open form) [polypeptide binding]; other site 649831013445 dimerization interface (closed form) [polypeptide binding]; other site 649831013446 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 649831013447 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 649831013448 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 649831013449 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 649831013450 active site 649831013451 Pirin-related protein [General function prediction only]; Region: COG1741 649831013452 Pirin; Region: Pirin; pfam02678 649831013453 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 649831013454 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 649831013455 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 649831013456 metal binding site [ion binding]; metal-binding site 649831013457 active site 649831013458 I-site; other site 649831013459 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 649831013460 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 649831013461 I-site; other site 649831013462 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 649831013463 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 649831013464 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 649831013465 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 649831013466 Acyltransferase family; Region: Acyl_transf_3; pfam01757 649831013467 CheW-like domain; Region: CheW; pfam01584 649831013468 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 649831013469 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649831013470 S-adenosylmethionine binding site [chemical binding]; other site 649831013471 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 649831013472 binding surface 649831013473 TPR motif; other site 649831013474 TPR repeat; Region: TPR_11; pfam13414 649831013475 CheW-like domain; Region: CheW; pfam01584 649831013476 CHASE3 domain; Region: CHASE3; cl05000 649831013477 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 649831013478 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 649831013479 dimer interface [polypeptide binding]; other site 649831013480 putative CheW interface [polypeptide binding]; other site 649831013481 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 649831013482 putative binding surface; other site 649831013483 active site 649831013484 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831013485 ATP binding site [chemical binding]; other site 649831013486 Mg2+ binding site [ion binding]; other site 649831013487 G-X-G motif; other site 649831013488 Response regulator receiver domain; Region: Response_reg; pfam00072 649831013489 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831013490 active site 649831013491 phosphorylation site [posttranslational modification] 649831013492 intermolecular recognition site; other site 649831013493 dimerization interface [polypeptide binding]; other site 649831013494 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 649831013495 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831013496 active site 649831013497 phosphorylation site [posttranslational modification] 649831013498 intermolecular recognition site; other site 649831013499 dimerization interface [polypeptide binding]; other site 649831013500 CheB methylesterase; Region: CheB_methylest; pfam01339 649831013501 Response regulator receiver domain; Region: Response_reg; pfam00072 649831013502 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831013503 active site 649831013504 phosphorylation site [posttranslational modification] 649831013505 intermolecular recognition site; other site 649831013506 dimerization interface [polypeptide binding]; other site 649831013507 Response regulator receiver domain; Region: Response_reg; pfam00072 649831013508 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831013509 active site 649831013510 phosphorylation site [posttranslational modification] 649831013511 intermolecular recognition site; other site 649831013512 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831013513 phosphorylation site [posttranslational modification] 649831013514 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 649831013515 dimer interface [polypeptide binding]; other site 649831013516 phosphorylation site [posttranslational modification] 649831013517 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831013518 ATP binding site [chemical binding]; other site 649831013519 Mg2+ binding site [ion binding]; other site 649831013520 G-X-G motif; other site 649831013521 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 649831013522 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 649831013523 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 649831013524 FtsX-like permease family; Region: FtsX; pfam02687 649831013525 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 649831013526 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 649831013527 Walker A/P-loop; other site 649831013528 ATP binding site [chemical binding]; other site 649831013529 Q-loop/lid; other site 649831013530 ABC transporter signature motif; other site 649831013531 Walker B; other site 649831013532 D-loop; other site 649831013533 H-loop/switch region; other site 649831013534 Histidine kinase; Region: HisKA_3; pfam07730 649831013535 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 649831013536 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649831013537 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831013538 active site 649831013539 phosphorylation site [posttranslational modification] 649831013540 intermolecular recognition site; other site 649831013541 dimerization interface [polypeptide binding]; other site 649831013542 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649831013543 DNA binding residues [nucleotide binding] 649831013544 dimerization interface [polypeptide binding]; other site 649831013545 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 649831013546 Trp docking motif [polypeptide binding]; other site 649831013547 active site 649831013548 PQQ-like domain; Region: PQQ_2; pfam13360 649831013549 Predicted acetyltransferase [General function prediction only]; Region: COG3981 649831013550 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 649831013551 Coenzyme A binding pocket [chemical binding]; other site 649831013552 Transcriptional regulators [Transcription]; Region: MarR; COG1846 649831013553 MarR family; Region: MarR_2; pfam12802 649831013554 MarR family; Region: MarR_2; cl17246 649831013555 Domain of unknown function (DUF305); Region: DUF305; cl17794 649831013556 Chitin binding domain; Region: Chitin_bind_3; pfam03067 649831013557 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 649831013558 active site 649831013559 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 649831013560 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649831013561 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649831013562 DNA binding residues [nucleotide binding] 649831013563 dimerization interface [polypeptide binding]; other site 649831013564 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 649831013565 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 649831013566 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 649831013567 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 649831013568 malate synthase A; Region: malate_syn_A; TIGR01344 649831013569 active site 649831013570 isocitrate lyase; Provisional; Region: PRK15063 649831013571 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 649831013572 tetramer interface [polypeptide binding]; other site 649831013573 active site 649831013574 Mg2+/Mn2+ binding site [ion binding]; other site 649831013575 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 649831013576 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 649831013577 non-specific DNA binding site [nucleotide binding]; other site 649831013578 salt bridge; other site 649831013579 sequence-specific DNA binding site [nucleotide binding]; other site 649831013580 Domain of unknown function (DUF955); Region: DUF955; pfam06114 649831013581 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 649831013582 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 649831013583 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 649831013584 putative NEF/HSP70 interaction site [polypeptide binding]; other site 649831013585 nucleotide binding site [chemical binding]; other site 649831013586 SBD interface [polypeptide binding]; other site 649831013587 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 649831013588 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 649831013589 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 649831013590 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 649831013591 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 649831013592 Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; pfam10069 649831013593 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 649831013594 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 649831013595 active site 649831013596 Zn binding site [ion binding]; other site 649831013597 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 649831013598 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 649831013599 active site 649831013600 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 649831013601 FMN binding site [chemical binding]; other site 649831013602 dimer interface [polypeptide binding]; other site 649831013603 MarR family; Region: MarR_2; pfam12802 649831013604 hypothetical protein; Provisional; Region: PRK07588 649831013605 hypothetical protein; Provisional; Region: PRK07236 649831013606 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 649831013607 dimerization interface [polypeptide binding]; other site 649831013608 putative DNA binding site [nucleotide binding]; other site 649831013609 putative Zn2+ binding site [ion binding]; other site 649831013610 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 649831013611 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831013612 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 649831013613 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 649831013614 putative NAD(P) binding site [chemical binding]; other site 649831013615 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 649831013616 putative hydrophobic ligand binding site [chemical binding]; other site 649831013617 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 649831013618 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 649831013619 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 649831013620 dimerization interface [polypeptide binding]; other site 649831013621 putative DNA binding site [nucleotide binding]; other site 649831013622 putative Zn2+ binding site [ion binding]; other site 649831013623 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649831013624 S-adenosylmethionine binding site [chemical binding]; other site 649831013625 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 649831013626 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 649831013627 putative NAD(P) binding site [chemical binding]; other site 649831013628 putative substrate binding site [chemical binding]; other site 649831013629 catalytic Zn binding site [ion binding]; other site 649831013630 structural Zn binding site [ion binding]; other site 649831013631 dimer interface [polypeptide binding]; other site 649831013632 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831013633 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 649831013634 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 649831013635 metal binding site [ion binding]; metal-binding site 649831013636 active site 649831013637 I-site; other site 649831013638 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 649831013639 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 649831013640 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 649831013641 metal binding site [ion binding]; metal-binding site 649831013642 active site 649831013643 I-site; other site 649831013644 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 649831013645 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 649831013646 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 649831013647 Walker A motif; other site 649831013648 ATP binding site [chemical binding]; other site 649831013649 Walker B motif; other site 649831013650 arginine finger; other site 649831013651 SnoaL-like domain; Region: SnoaL_3; pfam13474 649831013652 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 649831013653 Domain of unknown function (DUF1932); Region: DUF1932; pfam09130 649831013654 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 649831013655 Catalytic domain of Protein Kinases; Region: PKc; cd00180 649831013656 active site 649831013657 ATP binding site [chemical binding]; other site 649831013658 substrate binding site [chemical binding]; other site 649831013659 activation loop (A-loop); other site 649831013660 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649831013661 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831013662 active site 649831013663 phosphorylation site [posttranslational modification] 649831013664 intermolecular recognition site; other site 649831013665 dimerization interface [polypeptide binding]; other site 649831013666 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649831013667 DNA binding residues [nucleotide binding] 649831013668 dimerization interface [polypeptide binding]; other site 649831013669 Histidine kinase; Region: HisKA_3; pfam07730 649831013670 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 649831013671 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 649831013672 putative pectinesterase; Region: PLN02432; cl01911 649831013673 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 649831013674 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 649831013675 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 649831013676 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 649831013677 sequence-specific DNA binding site [nucleotide binding]; other site 649831013678 salt bridge; other site 649831013679 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831013680 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 649831013681 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649831013682 S-adenosylmethionine binding site [chemical binding]; other site 649831013683 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 649831013684 putative active site [active] 649831013685 putative catalytic site [active] 649831013686 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 649831013687 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 649831013688 DinB superfamily; Region: DinB_2; pfam12867 649831013689 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831013690 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 649831013691 Uncharacterized conserved protein [Function unknown]; Region: COG3342 649831013692 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 649831013693 Protein of unknown function (DUF998); Region: DUF998; pfam06197 649831013694 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649831013695 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831013696 active site 649831013697 phosphorylation site [posttranslational modification] 649831013698 intermolecular recognition site; other site 649831013699 dimerization interface [polypeptide binding]; other site 649831013700 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649831013701 DNA binding residues [nucleotide binding] 649831013702 Putative sensor; Region: Sensor; pfam13796 649831013703 Histidine kinase; Region: HisKA_3; pfam07730 649831013704 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 649831013705 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 649831013706 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 649831013707 Walker A/P-loop; other site 649831013708 ATP binding site [chemical binding]; other site 649831013709 Q-loop/lid; other site 649831013710 ABC transporter signature motif; other site 649831013711 Walker B; other site 649831013712 D-loop; other site 649831013713 H-loop/switch region; other site 649831013714 FtsX-like permease family; Region: FtsX; pfam02687 649831013715 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 649831013716 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 649831013717 acyl-activating enzyme (AAE) consensus motif; other site 649831013718 putative AMP binding site [chemical binding]; other site 649831013719 putative active site [active] 649831013720 putative CoA binding site [chemical binding]; other site 649831013721 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 649831013722 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 649831013723 substrate binding pocket [chemical binding]; other site 649831013724 membrane-bound complex binding site; other site 649831013725 hinge residues; other site 649831013726 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 649831013727 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 649831013728 Catalytic domain of Protein Kinases; Region: PKc; cd00180 649831013729 active site 649831013730 ATP binding site [chemical binding]; other site 649831013731 substrate binding site [chemical binding]; other site 649831013732 activation loop (A-loop); other site 649831013733 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 649831013734 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 649831013735 binding surface 649831013736 TPR motif; other site 649831013737 Double zinc ribbon; Region: DZR; pfam12773 649831013738 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 649831013739 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 649831013740 metal ion-dependent adhesion site (MIDAS); other site 649831013741 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 649831013742 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 649831013743 phosphopeptide binding site; other site 649831013744 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 649831013745 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 649831013746 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 649831013747 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 649831013748 active site 649831013749 Predicted membrane protein [Function unknown]; Region: COG4682 649831013750 yiaA/B two helix domain; Region: YiaAB; pfam05360 649831013751 yiaA/B two helix domain; Region: YiaAB; cl01759 649831013752 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 649831013753 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 649831013754 ATP binding site [chemical binding]; other site 649831013755 putative Mg++ binding site [ion binding]; other site 649831013756 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 649831013757 nucleotide binding region [chemical binding]; other site 649831013758 ATP-binding site [chemical binding]; other site 649831013759 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 649831013760 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 649831013761 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 649831013762 active site 649831013763 motif I; other site 649831013764 motif II; other site 649831013765 diacylglycerol kinase; Reviewed; Region: PRK11914 649831013766 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 649831013767 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 649831013768 DNA binding residues [nucleotide binding] 649831013769 short chain dehydrogenase; Validated; Region: PRK08264 649831013770 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831013771 NAD(P) binding site [chemical binding]; other site 649831013772 active site 649831013773 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 649831013774 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649831013775 Walker A/P-loop; other site 649831013776 ATP binding site [chemical binding]; other site 649831013777 Q-loop/lid; other site 649831013778 ABC transporter signature motif; other site 649831013779 Walker B; other site 649831013780 D-loop; other site 649831013781 H-loop/switch region; other site 649831013782 Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902 649831013783 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 649831013784 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 649831013785 Predicted transcriptional regulator [Transcription]; Region: COG2378 649831013786 WYL domain; Region: WYL; pfam13280 649831013787 Predicted transcriptional regulator [Transcription]; Region: COG2378 649831013788 WYL domain; Region: WYL; pfam13280 649831013789 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 649831013790 Cation efflux family; Region: Cation_efflux; pfam01545 649831013791 Protein of unknown function (DUF3866); Region: DUF3866; pfam12982 649831013792 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 649831013793 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 649831013794 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 649831013795 NAD binding site [chemical binding]; other site 649831013796 substrate binding site [chemical binding]; other site 649831013797 homodimer interface [polypeptide binding]; other site 649831013798 active site 649831013799 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 649831013800 active site 649831013801 metal binding site [ion binding]; metal-binding site 649831013802 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 649831013803 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 649831013804 active site 649831013805 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 649831013806 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 649831013807 active site 649831013808 Pup-like protein; Region: Pup; pfam05639 649831013809 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 649831013810 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1; Region: Cenp-F_leu_zip; pfam10473 649831013811 proteasome ATPase; Region: pup_AAA; TIGR03689 649831013812 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 649831013813 Walker A motif; other site 649831013814 ATP binding site [chemical binding]; other site 649831013815 Walker B motif; other site 649831013816 arginine finger; other site 649831013817 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 649831013818 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 649831013819 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649831013820 S-adenosylmethionine binding site [chemical binding]; other site 649831013821 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 649831013822 Peptidase family M50; Region: Peptidase_M50; pfam02163 649831013823 active site 649831013824 putative substrate binding region [chemical binding]; other site 649831013825 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 649831013826 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 649831013827 nudix motif; other site 649831013828 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 649831013829 Radical SAM superfamily; Region: Radical_SAM; pfam04055 649831013830 FeS/SAM binding site; other site 649831013831 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649831013832 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831013833 active site 649831013834 phosphorylation site [posttranslational modification] 649831013835 intermolecular recognition site; other site 649831013836 dimerization interface [polypeptide binding]; other site 649831013837 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649831013838 DNA binding residues [nucleotide binding] 649831013839 dimerization interface [polypeptide binding]; other site 649831013840 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 649831013841 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 649831013842 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 649831013843 Walker A/P-loop; other site 649831013844 ATP binding site [chemical binding]; other site 649831013845 Q-loop/lid; other site 649831013846 ABC transporter signature motif; other site 649831013847 Walker B; other site 649831013848 D-loop; other site 649831013849 H-loop/switch region; other site 649831013850 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 649831013851 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 649831013852 FtsX-like permease family; Region: FtsX; pfam02687 649831013853 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 649831013854 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 649831013855 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 649831013856 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 649831013857 motif II; other site 649831013858 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 649831013859 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 649831013860 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 649831013861 active site 649831013862 catalytic tetrad [active] 649831013863 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 649831013864 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 649831013865 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 649831013866 YCII-related domain; Region: YCII; cl00999 649831013867 Uncharacterized conserved protein (COG2071); Region: DUF2071; pfam09844 649831013868 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 649831013869 active site 649831013870 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 649831013871 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 649831013872 PAC2 family; Region: PAC2; pfam09754 649831013873 Methyltransferase domain; Region: Methyltransf_11; pfam08241 649831013874 Methyltransferase domain; Region: Methyltransf_24; pfam13578 649831013875 Predicted membrane protein (DUF2306); Region: DUF2306; cl02232 649831013876 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 649831013877 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 649831013878 DNA-binding site [nucleotide binding]; DNA binding site 649831013879 UTRA domain; Region: UTRA; pfam07702 649831013880 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 649831013881 Domain of unknown function (DUF1768); Region: DUF1768; pfam08719 649831013882 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 649831013883 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 649831013884 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 649831013885 active site 649831013886 HIGH motif; other site 649831013887 nucleotide binding site [chemical binding]; other site 649831013888 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 649831013889 active site 649831013890 KMSKS motif; other site 649831013891 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 649831013892 conserved hypothetical protein; Region: TIGR03843 649831013893 Protein of unknown function (DUF3090); Region: DUF3090; pfam11290 649831013894 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 649831013895 catalytic core [active] 649831013896 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 649831013897 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 649831013898 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 649831013899 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 649831013900 active site 649831013901 catalytic tetrad [active] 649831013902 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 649831013903 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 649831013904 putative NAD(P) binding site [chemical binding]; other site 649831013905 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 649831013906 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 649831013907 hypothetical protein; Provisional; Region: PRK07906 649831013908 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 649831013909 putative metal binding site [ion binding]; other site 649831013910 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 649831013911 Transcriptional regulator [Transcription]; Region: LysR; COG0583 649831013912 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 649831013913 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 649831013914 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 649831013915 Clp amino terminal domain; Region: Clp_N; pfam02861 649831013916 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 649831013917 Walker A motif; other site 649831013918 ATP binding site [chemical binding]; other site 649831013919 Walker B motif; other site 649831013920 arginine finger; other site 649831013921 UvrB/uvrC motif; Region: UVR; pfam02151 649831013922 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 649831013923 Walker A motif; other site 649831013924 ATP binding site [chemical binding]; other site 649831013925 Walker B motif; other site 649831013926 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 649831013927 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 649831013928 Cupin superfamily protein; Region: Cupin_4; pfam08007 649831013929 Cupin-like domain; Region: Cupin_8; pfam13621 649831013930 Protein of unknown function DUF72; Region: DUF72; pfam01904 649831013931 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 649831013932 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 649831013933 homodimer interface [polypeptide binding]; other site 649831013934 substrate-cofactor binding pocket; other site 649831013935 pyridoxal 5'-phosphate binding site [chemical binding]; other site 649831013936 catalytic residue [active] 649831013937 Protein of unknown function DUF72; Region: DUF72; pfam01904 649831013938 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 649831013939 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 649831013940 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 649831013941 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 649831013942 DNA binding site [nucleotide binding] 649831013943 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 649831013944 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 649831013945 Protein of unknown function (DUF3500); Region: DUF3500; pfam12006 649831013946 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 649831013947 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 649831013948 conserved cys residue [active] 649831013949 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 649831013950 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 649831013951 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 649831013952 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 649831013953 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 649831013954 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 649831013955 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 649831013956 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 649831013957 nucleotide binding region [chemical binding]; other site 649831013958 ATP-binding site [chemical binding]; other site 649831013959 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 649831013960 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649831013961 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 649831013962 Walker A/P-loop; other site 649831013963 ATP binding site [chemical binding]; other site 649831013964 Q-loop/lid; other site 649831013965 ABC transporter signature motif; other site 649831013966 Walker B; other site 649831013967 D-loop; other site 649831013968 H-loop/switch region; other site 649831013969 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 649831013970 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 649831013971 putative NAD(P) binding site [chemical binding]; other site 649831013972 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 649831013973 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 649831013974 Putative oxidoreductase C terminal; Region: ox_reductase_C; pfam08635 649831013975 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 649831013976 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 649831013977 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 649831013978 putative ADP-binding pocket [chemical binding]; other site 649831013979 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 649831013980 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 649831013981 CheB methylesterase; Region: CheB_methylest; pfam01339 649831013982 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 649831013983 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 649831013984 PAS domain; Region: PAS_9; pfam13426 649831013985 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 649831013986 heme pocket [chemical binding]; other site 649831013987 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 649831013988 anti sigma factor interaction site; other site 649831013989 regulatory phosphorylation site [posttranslational modification]; other site 649831013990 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 649831013991 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 649831013992 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 649831013993 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 649831013994 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 649831013995 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 649831013996 anti sigma factor interaction site; other site 649831013997 regulatory phosphorylation site [posttranslational modification]; other site 649831013998 large tegument protein UL36; Provisional; Region: PHA03247 649831013999 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 649831014000 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 649831014001 active site 649831014002 catalytic triad [active] 649831014003 oxyanion hole [active] 649831014004 integral membrane protein; Region: integ_memb_HG; TIGR03954 649831014005 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 649831014006 Beta-lactamase; Region: Beta-lactamase; pfam00144 649831014007 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 649831014008 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 649831014009 phosphoribosylanthranilate isomerase; Region: PLN02363 649831014010 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 649831014011 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 649831014012 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 649831014013 metal ion-dependent adhesion site (MIDAS); other site 649831014014 cob(I)alamin adenolsyltransferase/cobinamide ATP-dependent adenolsyltransferase; Validated; Region: PRK05986 649831014015 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 649831014016 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 649831014017 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 649831014018 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 649831014019 catalytic triad [active] 649831014020 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 649831014021 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 649831014022 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 649831014023 N- and C-terminal domain interface [polypeptide binding]; other site 649831014024 active site 649831014025 carbohydrate binding site [chemical binding]; other site 649831014026 ATP binding site [chemical binding]; other site 649831014027 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 649831014028 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 649831014029 homodimer interface [polypeptide binding]; other site 649831014030 active site 649831014031 TDP-binding site; other site 649831014032 acceptor substrate-binding pocket; other site 649831014033 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 649831014034 dimer interface [polypeptide binding]; other site 649831014035 Citrate synthase; Region: Citrate_synt; pfam00285 649831014036 active site 649831014037 citrylCoA binding site [chemical binding]; other site 649831014038 NADH binding [chemical binding]; other site 649831014039 cationic pore residues; other site 649831014040 oxalacetate/citrate binding site [chemical binding]; other site 649831014041 coenzyme A binding site [chemical binding]; other site 649831014042 catalytic triad [active] 649831014043 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 649831014044 Ligand Binding Site [chemical binding]; other site 649831014045 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 649831014046 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 649831014047 metal binding site [ion binding]; metal-binding site 649831014048 active site 649831014049 I-site; other site 649831014050 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 649831014051 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 649831014052 putative catalytic site [active] 649831014053 putative phosphate binding site [ion binding]; other site 649831014054 active site 649831014055 metal binding site A [ion binding]; metal-binding site 649831014056 DNA binding site [nucleotide binding] 649831014057 putative AP binding site [nucleotide binding]; other site 649831014058 putative metal binding site B [ion binding]; other site 649831014059 GAF domain; Region: GAF; cl17456 649831014060 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 649831014061 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 649831014062 B12 binding domain; Region: B12-binding_2; pfam02607 649831014063 B12 binding domain; Region: B12-binding; pfam02310 649831014064 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 649831014065 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 649831014066 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 649831014067 metal binding site [ion binding]; metal-binding site 649831014068 active site 649831014069 I-site; other site 649831014070 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 649831014071 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 649831014072 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 649831014073 ATP binding site [chemical binding]; other site 649831014074 putative Mg++ binding site [ion binding]; other site 649831014075 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 649831014076 nucleotide binding region [chemical binding]; other site 649831014077 ATP-binding site [chemical binding]; other site 649831014078 Helicase associated domain (HA2); Region: HA2; pfam04408 649831014079 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 649831014080 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 649831014081 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 649831014082 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 649831014083 dimer interface [polypeptide binding]; other site 649831014084 phosphorylation site [posttranslational modification] 649831014085 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831014086 ATP binding site [chemical binding]; other site 649831014087 Mg2+ binding site [ion binding]; other site 649831014088 G-X-G motif; other site 649831014089 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 649831014090 PAP2 superfamily; Region: PAP2; pfam01569 649831014091 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 649831014092 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 649831014093 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 649831014094 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 649831014095 DNA binding residues [nucleotide binding] 649831014096 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR8; cd08273 649831014097 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 649831014098 putative NAD(P) binding site [chemical binding]; other site 649831014099 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 649831014100 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 649831014101 nucleotide binding site [chemical binding]; other site 649831014102 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 649831014103 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649831014104 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 649831014105 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 649831014106 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 649831014107 active site 649831014108 homodimer interface [polypeptide binding]; other site 649831014109 catalytic site [active] 649831014110 acceptor binding site [chemical binding]; other site 649831014111 trehalose synthase; Region: treS_nterm; TIGR02456 649831014112 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 649831014113 active site 649831014114 catalytic site [active] 649831014115 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 649831014116 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 649831014117 glycogen branching enzyme; Provisional; Region: PRK05402 649831014118 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 649831014119 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 649831014120 active site 649831014121 catalytic site [active] 649831014122 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 649831014123 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 649831014124 NB-ARC domain; Region: NB-ARC; pfam00931 649831014125 Tetratricopeptide repeat; Region: TPR_12; pfam13424 649831014126 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 649831014127 binding surface 649831014128 TPR motif; other site 649831014129 Tetratricopeptide repeat; Region: TPR_12; pfam13424 649831014130 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 649831014131 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 649831014132 phosphate binding site [ion binding]; other site 649831014133 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 649831014134 tetracycline repressor protein TetR; Provisional; Region: PRK13756 649831014135 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831014136 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 649831014137 hypothetical protein; Provisional; Region: PRK07588 649831014138 hypothetical protein; Provisional; Region: PRK07236 649831014139 hypothetical protein; Provisional; Region: PRK07236 649831014140 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 649831014141 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 649831014142 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 649831014143 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 649831014144 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 649831014145 active site 649831014146 AAA ATPase domain; Region: AAA_16; pfam13191 649831014147 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649831014148 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649831014149 DNA binding residues [nucleotide binding] 649831014150 dimerization interface [polypeptide binding]; other site 649831014151 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 649831014152 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 649831014153 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 649831014154 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 649831014155 RNA binding site [nucleotide binding]; other site 649831014156 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 649831014157 Histidine kinase; Region: HisKA_3; pfam07730 649831014158 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 649831014159 ATP binding site [chemical binding]; other site 649831014160 Mg2+ binding site [ion binding]; other site 649831014161 G-X-G motif; other site 649831014162 Response regulator receiver domain; Region: Response_reg; pfam00072 649831014163 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831014164 active site 649831014165 phosphorylation site [posttranslational modification] 649831014166 intermolecular recognition site; other site 649831014167 dimerization interface [polypeptide binding]; other site 649831014168 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649831014169 DNA binding residues [nucleotide binding] 649831014170 Protein of unknown function (DUF3626); Region: DUF3626; pfam12294 649831014171 Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013 649831014172 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831014173 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 649831014174 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 649831014175 hypothetical protein; Provisional; Region: PRK06762 649831014176 AAA domain; Region: AAA_33; pfam13671 649831014177 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094 649831014178 Catalytic domain of Protein Kinases; Region: PKc; cd00180 649831014179 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 649831014180 active site 649831014181 ATP binding site [chemical binding]; other site 649831014182 substrate binding site [chemical binding]; other site 649831014183 activation loop (A-loop); other site 649831014184 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 649831014185 Catalytic domain of Protein Kinases; Region: PKc; cd00180 649831014186 active site 649831014187 ATP binding site [chemical binding]; other site 649831014188 substrate binding site [chemical binding]; other site 649831014189 activation loop (A-loop); other site 649831014190 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 649831014191 SLBB domain; Region: SLBB; pfam10531 649831014192 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 649831014193 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 649831014194 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 649831014195 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 649831014196 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 649831014197 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 649831014198 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 649831014199 active site 649831014200 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 649831014201 MarR family; Region: MarR; pfam01047 649831014202 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649831014203 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 649831014204 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831014205 putative substrate translocation pore; other site 649831014206 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 649831014207 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 649831014208 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 649831014209 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 649831014210 calcium mediated ligand binding site; other site 649831014211 intermolecular salt bridges; other site 649831014212 CutC family; Region: CutC; cl01218 649831014213 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 649831014214 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 649831014215 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 649831014216 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 649831014217 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 649831014218 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 649831014219 ligand binding site [chemical binding]; other site 649831014220 flexible hinge region; other site 649831014221 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 649831014222 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 649831014223 Lipase (class 2); Region: Lipase_2; pfam01674 649831014224 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649831014225 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649831014226 DNA binding residues [nucleotide binding] 649831014227 dimerization interface [polypeptide binding]; other site 649831014228 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 649831014229 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 649831014230 active site 649831014231 catalytic site [active] 649831014232 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 649831014233 substrate binding site [chemical binding]; other site 649831014234 THF binding site; other site 649831014235 zinc-binding site [ion binding]; other site 649831014236 glycyl-tRNA synthetase; Provisional; Region: PRK14908 649831014237 glycyl-tRNA synthetase subunit alpha; Validated; Region: glyQ; PRK09348 649831014238 motif 1; other site 649831014239 dimer interface [polypeptide binding]; other site 649831014240 active site 649831014241 motif 2; other site 649831014242 motif 3; other site 649831014243 acyl-coenzyme A oxidase; Region: PLN02526 649831014244 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 649831014245 active site 649831014246 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 649831014247 MarR family; Region: MarR_2; pfam12802 649831014248 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 649831014249 NmrA-like family; Region: NmrA; pfam05368 649831014250 NADP binding site [chemical binding]; other site 649831014251 active site 649831014252 regulatory binding site [polypeptide binding]; other site 649831014253 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 649831014254 glycerol kinase; Provisional; Region: glpK; PRK00047 649831014255 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 649831014256 N- and C-terminal domain interface [polypeptide binding]; other site 649831014257 active site 649831014258 MgATP binding site [chemical binding]; other site 649831014259 catalytic site [active] 649831014260 metal binding site [ion binding]; metal-binding site 649831014261 putative homotetramer interface [polypeptide binding]; other site 649831014262 glycerol binding site [chemical binding]; other site 649831014263 homodimer interface [polypeptide binding]; other site 649831014264 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 649831014265 amphipathic channel; other site 649831014266 Asn-Pro-Ala signature motifs; other site 649831014267 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 649831014268 Transcriptional regulator [Transcription]; Region: IclR; COG1414 649831014269 Bacterial transcriptional regulator; Region: IclR; pfam01614 649831014270 glycerol kinase; Provisional; Region: glpK; PRK00047 649831014271 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 649831014272 nucleotide binding site [chemical binding]; other site 649831014273 Protein of unknown function (DUF3253); Region: DUF3253; pfam11625 649831014274 Domain of unknown function (DUF427); Region: DUF427; pfam04248 649831014275 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 649831014276 DNA binding residues [nucleotide binding] 649831014277 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 649831014278 classical (c) SDRs; Region: SDR_c; cd05233 649831014279 NAD(P) binding site [chemical binding]; other site 649831014280 active site 649831014281 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 649831014282 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 649831014283 non-specific DNA binding site [nucleotide binding]; other site 649831014284 salt bridge; other site 649831014285 sequence-specific DNA binding site [nucleotide binding]; other site 649831014286 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 649831014287 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 649831014288 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT); Region: PCMT; pfam01135 649831014289 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649831014290 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 649831014291 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 649831014292 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 649831014293 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT; cl04176 649831014294 gating phenylalanine in ion channel; other site 649831014295 Clp amino terminal domain; Region: Clp_N; pfam02861 649831014296 TM1410 hypothetical-related protein; Region: DUF297; pfam03537 649831014297 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 649831014298 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831014299 NAD(P) binding site [chemical binding]; other site 649831014300 active site 649831014301 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 649831014302 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 649831014303 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 649831014304 TM1410 hypothetical-related protein; Region: DUF297; cl00997 649831014305 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831014306 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 649831014307 NAD(P) binding site [chemical binding]; other site 649831014308 active site 649831014309 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 649831014310 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 649831014311 active site 649831014312 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 649831014313 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 649831014314 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 649831014315 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 649831014316 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 649831014317 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 649831014318 inhibitor-cofactor binding pocket; inhibition site 649831014319 pyridoxal 5'-phosphate binding site [chemical binding]; other site 649831014320 catalytic residue [active] 649831014321 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 649831014322 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 649831014323 DNA-binding site [nucleotide binding]; DNA binding site 649831014324 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 649831014325 pyridoxal 5'-phosphate binding site [chemical binding]; other site 649831014326 homodimer interface [polypeptide binding]; other site 649831014327 catalytic residue [active] 649831014328 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 649831014329 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 649831014330 active site 649831014331 catalytic triad [active] 649831014332 dimer interface [polypeptide binding]; other site 649831014333 phenylhydantoinase; Validated; Region: PRK08323 649831014334 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 649831014335 tetramer interface [polypeptide binding]; other site 649831014336 active site 649831014337 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 649831014338 F420-dependent oxidoreductase, CPS_4043 family; Region: F420_CPS_4043; TIGR03842 649831014339 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 649831014340 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 649831014341 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 649831014342 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 649831014343 Walker A/P-loop; other site 649831014344 ATP binding site [chemical binding]; other site 649831014345 Q-loop/lid; other site 649831014346 ABC transporter signature motif; other site 649831014347 Walker B; other site 649831014348 D-loop; other site 649831014349 H-loop/switch region; other site 649831014350 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 649831014351 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 649831014352 NMT1/THI5 like; Region: NMT1; pfam09084 649831014353 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 649831014354 Catalytic domain of Protein Kinases; Region: PKc; cd00180 649831014355 active site 649831014356 ATP binding site [chemical binding]; other site 649831014357 substrate binding site [chemical binding]; other site 649831014358 activation loop (A-loop); other site 649831014359 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 649831014360 sugar binding site [chemical binding]; other site 649831014361 Transcriptional regulators [Transcription]; Region: MarR; COG1846 649831014362 MarR family; Region: MarR_2; pfam12802 649831014363 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 649831014364 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 649831014365 D-xylose ABC transporter, substrate-binding protein; Region: xylF; TIGR02634 649831014366 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 649831014367 putative ligand binding site [chemical binding]; other site 649831014368 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 649831014369 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 649831014370 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 649831014371 TM-ABC transporter signature motif; other site 649831014372 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 649831014373 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 649831014374 Walker A/P-loop; other site 649831014375 ATP binding site [chemical binding]; other site 649831014376 Q-loop/lid; other site 649831014377 ABC transporter signature motif; other site 649831014378 Walker B; other site 649831014379 D-loop; other site 649831014380 H-loop/switch region; other site 649831014381 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 649831014382 MMPL family; Region: MMPL; pfam03176 649831014383 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 649831014384 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 649831014385 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831014386 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 649831014387 MarR family; Region: MarR_2; pfam12802 649831014388 MarR family; Region: MarR_2; cl17246 649831014389 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 649831014390 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 649831014391 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 649831014392 Walker A/P-loop; other site 649831014393 ATP binding site [chemical binding]; other site 649831014394 Q-loop/lid; other site 649831014395 ABC transporter signature motif; other site 649831014396 Walker B; other site 649831014397 D-loop; other site 649831014398 H-loop/switch region; other site 649831014399 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 649831014400 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 649831014401 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 649831014402 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649831014403 S-adenosylmethionine binding site [chemical binding]; other site 649831014404 Domain of unknown function (DUF222); Region: DUF222; pfam02720 649831014405 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 649831014406 active site 649831014407 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 649831014408 putative catalytic site [active] 649831014409 putative metal binding site [ion binding]; other site 649831014410 putative phosphate binding site [ion binding]; other site 649831014411 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 649831014412 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 649831014413 active site 649831014414 catalytic site [active] 649831014415 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 649831014416 carbohydrate binding site [chemical binding]; other site 649831014417 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 649831014418 carbohydrate binding site [chemical binding]; other site 649831014419 alpha-1,6-glucosidases, pullulanase-type; Region: pullul_strch; TIGR02103 649831014420 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 649831014421 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 649831014422 Ca binding site [ion binding]; other site 649831014423 active site 649831014424 catalytic site [active] 649831014425 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 649831014426 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 649831014427 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 649831014428 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 649831014429 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 649831014430 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 649831014431 FAD binding pocket [chemical binding]; other site 649831014432 FAD binding motif [chemical binding]; other site 649831014433 phosphate binding motif [ion binding]; other site 649831014434 NAD binding pocket [chemical binding]; other site 649831014435 Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060 649831014436 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 649831014437 HIGH motif; other site 649831014438 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 649831014439 active site 649831014440 KMSKS motif; other site 649831014441 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 649831014442 tRNA binding surface [nucleotide binding]; other site 649831014443 anticodon binding site; other site 649831014444 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 649831014445 active site 649831014446 catalytic site [active] 649831014447 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 649831014448 FAD binding domain; Region: FAD_binding_4; pfam01565 649831014449 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 649831014450 Lamin Tail Domain; Region: LTD; pfam00932 649831014451 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 649831014452 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 649831014453 dimer interface [polypeptide binding]; other site 649831014454 active site 649831014455 Coenzyme A transferase; Region: CoA_trans; cl17247 649831014456 Coenzyme A transferase; Region: CoA_trans; cl17247 649831014457 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831014458 Secretory lipase; Region: LIP; pfam03583 649831014459 Beta-lactamase; Region: Beta-lactamase; pfam00144 649831014460 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 649831014461 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 649831014462 probable polyamine oxidase; Region: PLN02268 649831014463 Transcriptional regulators [Transcription]; Region: PurR; COG1609 649831014464 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 649831014465 DNA binding site [nucleotide binding] 649831014466 domain linker motif; other site 649831014467 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 649831014468 putative dimerization interface [polypeptide binding]; other site 649831014469 putative ligand binding site [chemical binding]; other site 649831014470 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 649831014471 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649831014472 Walker A/P-loop; other site 649831014473 ATP binding site [chemical binding]; other site 649831014474 Q-loop/lid; other site 649831014475 ABC transporter signature motif; other site 649831014476 Walker B; other site 649831014477 D-loop; other site 649831014478 H-loop/switch region; other site 649831014479 ABC-2 type transporter; Region: ABC2_membrane; cl17235 649831014480 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 649831014481 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 649831014482 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 649831014483 DNA binding residues [nucleotide binding] 649831014484 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 649831014485 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 649831014486 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 649831014487 active site 649831014488 catalytic tetrad [active] 649831014489 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 649831014490 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 649831014491 active site 649831014492 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 649831014493 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 649831014494 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 649831014495 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 649831014496 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 649831014497 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 649831014498 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 649831014499 ligand binding site [chemical binding]; other site 649831014500 flexible hinge region; other site 649831014501 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 649831014502 AAA ATPase domain; Region: AAA_16; pfam13191 649831014503 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649831014504 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649831014505 DNA binding residues [nucleotide binding] 649831014506 dimerization interface [polypeptide binding]; other site 649831014507 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 649831014508 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831014509 NAD(P) binding site [chemical binding]; other site 649831014510 active site 649831014511 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 649831014512 FAD binding domain; Region: FAD_binding_3; pfam01494 649831014513 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 649831014514 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 649831014515 acyl-activating enzyme (AAE) consensus motif; other site 649831014516 active site 649831014517 AMP binding site [chemical binding]; other site 649831014518 CoA binding site [chemical binding]; other site 649831014519 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 649831014520 3-dehydroquinate synthase; Provisional; Region: PRK02290 649831014521 Class I aldolases; Region: Aldolase_Class_I; cl17187 649831014522 catalytic residue [active] 649831014523 chorismate binding enzyme; Region: Chorismate_bind; cl10555 649831014524 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 649831014525 Glutamine amidotransferase class-I; Region: GATase; pfam00117 649831014526 conserved cys residue [active] 649831014527 AAA ATPase domain; Region: AAA_16; pfam13191 649831014528 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649831014529 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649831014530 DNA binding residues [nucleotide binding] 649831014531 dimerization interface [polypeptide binding]; other site 649831014532 hypothetical protein; Provisional; Region: PRK06126 649831014533 ATP-grasp domain; Region: ATP-grasp_4; cl17255 649831014534 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 649831014535 nudix motif; other site 649831014536 Cellulose binding domain; Region: CBM_2; pfam00553 649831014537 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 649831014538 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 649831014539 CBD_II domain; Region: CBD_II; smart00637 649831014540 Cellulose binding domain; Region: CBM_2; pfam00553 649831014541 Chitin binding domain; Region: Chitin_bind_3; pfam03067 649831014542 Cellulose binding domain; Region: CBM_2; pfam00553 649831014543 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 649831014544 CBD_II domain; Region: CBD_II; smart00637 649831014545 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 649831014546 Cytochrome P450; Region: p450; cl12078 649831014547 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 649831014548 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 649831014549 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 649831014550 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 649831014551 FAD binding pocket [chemical binding]; other site 649831014552 FAD binding motif [chemical binding]; other site 649831014553 phosphate binding motif [ion binding]; other site 649831014554 beta-alpha-beta structure motif; other site 649831014555 NAD binding pocket [chemical binding]; other site 649831014556 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 649831014557 catalytic loop [active] 649831014558 iron binding site [ion binding]; other site 649831014559 Fatty acid desaturase; Region: FA_desaturase; pfam00487 649831014560 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 649831014561 putative di-iron ligands [ion binding]; other site 649831014562 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 649831014563 Tannase and feruloyl esterase; Region: Tannase; pfam07519 649831014564 Tannase and feruloyl esterase; Region: Tannase; pfam07519 649831014565 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 649831014566 GAF domain; Region: GAF; pfam01590 649831014567 ANTAR domain; Region: ANTAR; pfam03861 649831014568 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 649831014569 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 649831014570 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 649831014571 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 649831014572 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 649831014573 GAF domain; Region: GAF_3; pfam13492 649831014574 GAF domain; Region: GAF_2; pfam13185 649831014575 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 649831014576 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 649831014577 dimer interface [polypeptide binding]; other site 649831014578 phosphorylation site [posttranslational modification] 649831014579 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831014580 ATP binding site [chemical binding]; other site 649831014581 Mg2+ binding site [ion binding]; other site 649831014582 G-X-G motif; other site 649831014583 Response regulator receiver domain; Region: Response_reg; pfam00072 649831014584 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831014585 active site 649831014586 phosphorylation site [posttranslational modification] 649831014587 intermolecular recognition site; other site 649831014588 dimerization interface [polypeptide binding]; other site 649831014589 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 649831014590 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 649831014591 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 649831014592 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 649831014593 active site 649831014594 catalytic triad [active] 649831014595 oxyanion hole [active] 649831014596 amino acid transporter; Region: 2A0306; TIGR00909 649831014597 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 649831014598 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 649831014599 metal ion-dependent adhesion site (MIDAS); other site 649831014600 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cd00105 649831014601 nucleic acid binding region [nucleotide binding]; other site 649831014602 G-X-X-G motif; other site 649831014603 Caspase domain; Region: Peptidase_C14; pfam00656 649831014604 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 649831014605 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 649831014606 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 649831014607 nucleotidyl binding site; other site 649831014608 metal binding site [ion binding]; metal-binding site 649831014609 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 649831014610 metal ion-dependent adhesion site (MIDAS); other site 649831014611 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 649831014612 metal ion-dependent adhesion site (MIDAS); other site 649831014613 Protein phosphatase 2C; Region: PP2C_2; pfam13672 649831014614 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 649831014615 substrate binding site [chemical binding]; other site 649831014616 activation loop (A-loop); other site 649831014617 phage tail protein domain; Region: tail_TIGR02242 649831014618 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 649831014619 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 649831014620 putative ligand binding site [chemical binding]; other site 649831014621 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 649831014622 dimerization interface [polypeptide binding]; other site 649831014623 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 649831014624 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 649831014625 putative CheW interface [polypeptide binding]; other site 649831014626 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 649831014627 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831014628 ATP binding site [chemical binding]; other site 649831014629 Mg2+ binding site [ion binding]; other site 649831014630 G-X-G motif; other site 649831014631 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 649831014632 Protein of unknown function (DUF742); Region: DUF742; pfam05331 649831014633 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 649831014634 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 649831014635 G2 box; other site 649831014636 Switch I region; other site 649831014637 G3 box; other site 649831014638 Switch II region; other site 649831014639 G4 box; other site 649831014640 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 649831014641 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 649831014642 active site 649831014643 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 649831014644 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 649831014645 ligand binding site [chemical binding]; other site 649831014646 flexible hinge region; other site 649831014647 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 649831014648 H+ Antiporter protein; Region: 2A0121; TIGR00900 649831014649 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831014650 putative substrate translocation pore; other site 649831014651 Predicted peptidase [General function prediction only]; Region: COG4099 649831014652 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 649831014653 active site 649831014654 Zn binding site [ion binding]; other site 649831014655 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 649831014656 thiamine pyrophosphate protein; Provisional; Region: PRK08273 649831014657 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 649831014658 PYR/PP interface [polypeptide binding]; other site 649831014659 tetramer interface [polypeptide binding]; other site 649831014660 dimer interface [polypeptide binding]; other site 649831014661 TPP binding site [chemical binding]; other site 649831014662 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 649831014663 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 649831014664 TPP-binding site [chemical binding]; other site 649831014665 Amidohydrolase; Region: Amidohydro_2; pfam04909 649831014666 MarR family; Region: MarR_2; pfam12802 649831014667 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 649831014668 Fe-S cluster binding site [ion binding]; other site 649831014669 DNA binding site [nucleotide binding] 649831014670 active site 649831014671 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 649831014672 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831014673 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831014674 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 649831014675 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 649831014676 Zn binding site [ion binding]; other site 649831014677 MarR family; Region: MarR_2; cl17246 649831014678 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 649831014679 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 649831014680 RHS Repeat; Region: RHS_repeat; cl11982 649831014681 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 649831014682 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 649831014683 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831014684 putative substrate translocation pore; other site 649831014685 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831014686 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831014687 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 649831014688 dimer interface [polypeptide binding]; other site 649831014689 putative CheW interface [polypeptide binding]; other site 649831014690 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 649831014691 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649831014692 Walker A/P-loop; other site 649831014693 ATP binding site [chemical binding]; other site 649831014694 Q-loop/lid; other site 649831014695 ABC transporter signature motif; other site 649831014696 Walker B; other site 649831014697 D-loop; other site 649831014698 H-loop/switch region; other site 649831014699 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 649831014700 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 649831014701 Phosphoesterase family; Region: Phosphoesterase; pfam04185 649831014702 Phosphoesterase family; Region: Phosphoesterase; pfam04185 649831014703 translocation protein TolB; Provisional; Region: tolB; PRK04922 649831014704 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831014705 Major Facilitator Superfamily; Region: MFS_1; pfam07690 649831014706 putative substrate translocation pore; other site 649831014707 Phosphoesterase family; Region: Phosphoesterase; pfam04185 649831014708 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 649831014709 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 649831014710 active site 649831014711 substrate binding site [chemical binding]; other site 649831014712 FMN binding site [chemical binding]; other site 649831014713 putative catalytic residues [active] 649831014714 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 649831014715 sequence-specific DNA binding site [nucleotide binding]; other site 649831014716 salt bridge; other site 649831014717 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 649831014718 dimerization interface [polypeptide binding]; other site 649831014719 putative DNA binding site [nucleotide binding]; other site 649831014720 putative Zn2+ binding site [ion binding]; other site 649831014721 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 649831014722 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 649831014723 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 649831014724 FAD binding domain; Region: FAD_binding_4; pfam01565 649831014725 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cl08044 649831014726 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 649831014727 Cysteine-rich domain; Region: CCG; pfam02754 649831014728 Transcriptional regulators [Transcription]; Region: GntR; COG1802 649831014729 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 649831014730 DNA-binding site [nucleotide binding]; DNA binding site 649831014731 Transglycosylase; Region: Transgly; pfam00912 649831014732 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 649831014733 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 649831014734 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 649831014735 Cation efflux family; Region: Cation_efflux; pfam01545 649831014736 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 649831014737 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 649831014738 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 649831014739 Predicted membrane protein (DUF2243); Region: DUF2243; pfam10002 649831014740 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 649831014741 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 649831014742 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 649831014743 active site 649831014744 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 649831014745 Catalytic domain of Protein Kinases; Region: PKc; cd00180 649831014746 active site 649831014747 ATP binding site [chemical binding]; other site 649831014748 substrate binding site [chemical binding]; other site 649831014749 activation loop (A-loop); other site 649831014750 Amb_all domain; Region: Amb_all; smart00656 649831014751 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 649831014752 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649831014753 S-adenosylmethionine binding site [chemical binding]; other site 649831014754 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 649831014755 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 649831014756 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 649831014757 Cytochrome P450; Region: p450; cl12078 649831014758 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 649831014759 Cytochrome P450; Region: p450; cl12078 649831014760 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 649831014761 putative DNA binding site [nucleotide binding]; other site 649831014762 putative Zn2+ binding site [ion binding]; other site 649831014763 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831014764 putative substrate translocation pore; other site 649831014765 DNA polymerase IV; Provisional; Region: PRK03348 649831014766 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 649831014767 active site 649831014768 DNA binding site [nucleotide binding] 649831014769 Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141 649831014770 putative RNAase interaction site [polypeptide binding]; other site 649831014771 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 649831014772 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 649831014773 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 649831014774 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 649831014775 Right handed beta helix region; Region: Beta_helix; pfam13229 649831014776 Right handed beta helix region; Region: Beta_helix; pfam13229 649831014777 Hyaluronan synthases catalyze polymerization of hyaluronan; Region: GT2_HAS; cd06434 649831014778 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 649831014779 DXD motif; other site 649831014780 L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 649831014781 putative N- and C-terminal domain interface [polypeptide binding]; other site 649831014782 D-xylulose kinase; Region: XylB; TIGR01312 649831014783 putative active site [active] 649831014784 MgATP binding site [chemical binding]; other site 649831014785 catalytic site [active] 649831014786 metal binding site [ion binding]; metal-binding site 649831014787 putative carbohydrate binding site [chemical binding]; other site 649831014788 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 649831014789 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 649831014790 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 649831014791 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649831014792 dimer interface [polypeptide binding]; other site 649831014793 conserved gate region; other site 649831014794 putative PBP binding loops; other site 649831014795 ABC-ATPase subunit interface; other site 649831014796 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 649831014797 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649831014798 putative PBP binding loops; other site 649831014799 dimer interface [polypeptide binding]; other site 649831014800 ABC-ATPase subunit interface; other site 649831014801 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 649831014802 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 649831014803 Walker A/P-loop; other site 649831014804 ATP binding site [chemical binding]; other site 649831014805 Q-loop/lid; other site 649831014806 ABC transporter signature motif; other site 649831014807 Walker B; other site 649831014808 D-loop; other site 649831014809 H-loop/switch region; other site 649831014810 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 649831014811 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 649831014812 Walker A/P-loop; other site 649831014813 ATP binding site [chemical binding]; other site 649831014814 Q-loop/lid; other site 649831014815 ABC transporter signature motif; other site 649831014816 Walker B; other site 649831014817 D-loop; other site 649831014818 H-loop/switch region; other site 649831014819 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 649831014820 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 649831014821 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 649831014822 active site clefts [active] 649831014823 zinc binding site [ion binding]; other site 649831014824 dimer interface [polypeptide binding]; other site 649831014825 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 649831014826 dimer interface [polypeptide binding]; other site 649831014827 FMN binding site [chemical binding]; other site 649831014828 NADPH bind site [chemical binding]; other site 649831014829 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 649831014830 Protein of unknown function (DUF1684); Region: DUF1684; pfam07920 649831014831 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 649831014832 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 649831014833 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 649831014834 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649831014835 dimer interface [polypeptide binding]; other site 649831014836 conserved gate region; other site 649831014837 putative PBP binding loops; other site 649831014838 ABC-ATPase subunit interface; other site 649831014839 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 649831014840 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649831014841 dimer interface [polypeptide binding]; other site 649831014842 conserved gate region; other site 649831014843 putative PBP binding loops; other site 649831014844 ABC-ATPase subunit interface; other site 649831014845 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 649831014846 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 649831014847 Walker A/P-loop; other site 649831014848 ATP binding site [chemical binding]; other site 649831014849 Q-loop/lid; other site 649831014850 ABC transporter signature motif; other site 649831014851 Walker B; other site 649831014852 D-loop; other site 649831014853 H-loop/switch region; other site 649831014854 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 649831014855 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 649831014856 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 649831014857 Walker A/P-loop; other site 649831014858 ATP binding site [chemical binding]; other site 649831014859 Q-loop/lid; other site 649831014860 ABC transporter signature motif; other site 649831014861 Walker B; other site 649831014862 D-loop; other site 649831014863 H-loop/switch region; other site 649831014864 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 649831014865 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 649831014866 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 649831014867 substrate binding site [chemical binding]; other site 649831014868 oxyanion hole (OAH) forming residues; other site 649831014869 Helix-turn-helix domain; Region: HTH_20; pfam12840 649831014870 dimerization interface [polypeptide binding]; other site 649831014871 putative DNA binding site [nucleotide binding]; other site 649831014872 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 649831014873 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 649831014874 active site 649831014875 dimer interface [polypeptide binding]; other site 649831014876 non-prolyl cis peptide bond; other site 649831014877 insertion regions; other site 649831014878 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 649831014879 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 649831014880 active site 649831014881 non-prolyl cis peptide bond; other site 649831014882 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 649831014883 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 649831014884 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649831014885 Walker A/P-loop; other site 649831014886 ATP binding site [chemical binding]; other site 649831014887 Q-loop/lid; other site 649831014888 ABC transporter signature motif; other site 649831014889 Walker B; other site 649831014890 D-loop; other site 649831014891 H-loop/switch region; other site 649831014892 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 649831014893 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649831014894 dimer interface [polypeptide binding]; other site 649831014895 conserved gate region; other site 649831014896 putative PBP binding loops; other site 649831014897 ABC-ATPase subunit interface; other site 649831014898 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 649831014899 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 649831014900 MarR family; Region: MarR_2; pfam12802 649831014901 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 649831014902 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 649831014903 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 649831014904 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 649831014905 Cupin domain; Region: Cupin_2; pfam07883 649831014906 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 649831014907 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831014908 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 649831014909 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 649831014910 sequence-specific DNA binding site [nucleotide binding]; other site 649831014911 salt bridge; other site 649831014912 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 649831014913 active site 649831014914 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831014915 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 649831014916 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 649831014917 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 649831014918 DNA binding residues [nucleotide binding] 649831014919 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 649831014920 DNA binding site [nucleotide binding] 649831014921 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 649831014922 Endoglucanase E-like members of the SGNH hydrolase family; Endoglucanase E catalyzes the endohydrolysis of 1,4-beta-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; Region: Endoglucanase_E_like; cd01831 649831014923 active site 649831014924 catalytic triad [active] 649831014925 oxyanion hole [active] 649831014926 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 649831014927 active site 649831014928 catalytic triad [active] 649831014929 oxyanion hole [active] 649831014930 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 649831014931 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 649831014932 Phosphotransferase enzyme family; Region: APH; pfam01636 649831014933 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 649831014934 ATP binding site [chemical binding]; other site 649831014935 substrate-cofactor binding pocket; other site 649831014936 Aminotransferase class IV; Region: Aminotran_4; pfam01063 649831014937 pyridoxal 5'-phosphate binding site [chemical binding]; other site 649831014938 glycoside hydrolase family 64: laminaripentaose-producing, beta-1,3-glucanase (LPHase)-like; Region: GH64-LPHase-like; cd09216 649831014939 substrate binding pocket [chemical binding]; other site 649831014940 catalytic residues [active] 649831014941 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 649831014942 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 649831014943 putative sugar binding sites [chemical binding]; other site 649831014944 Q-X-W motif; other site 649831014945 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 649831014946 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 649831014947 Walker A/P-loop; other site 649831014948 ATP binding site [chemical binding]; other site 649831014949 Q-loop/lid; other site 649831014950 ABC transporter signature motif; other site 649831014951 Walker B; other site 649831014952 D-loop; other site 649831014953 H-loop/switch region; other site 649831014954 Predicted transcriptional regulators [Transcription]; Region: COG1695 649831014955 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 649831014956 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 649831014957 Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457 649831014958 PaaX-like protein; Region: PaaX; pfam07848 649831014959 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 649831014960 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 649831014961 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 649831014962 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831014963 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 649831014964 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831014965 NAD(P) binding site [chemical binding]; other site 649831014966 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 649831014967 active site 649831014968 AAA ATPase domain; Region: AAA_16; pfam13191 649831014969 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649831014970 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649831014971 DNA binding residues [nucleotide binding] 649831014972 dimerization interface [polypeptide binding]; other site 649831014973 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 649831014974 tartrate dehydrogenase; Region: TTC; TIGR02089 649831014975 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 649831014976 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 649831014977 pyridoxal 5'-phosphate binding site [chemical binding]; other site 649831014978 homodimer interface [polypeptide binding]; other site 649831014979 catalytic residue [active] 649831014980 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 649831014981 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 649831014982 substrate binding site [chemical binding]; other site 649831014983 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 649831014984 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 649831014985 substrate binding site [chemical binding]; other site 649831014986 ligand binding site [chemical binding]; other site 649831014987 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 649831014988 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 649831014989 active site 649831014990 catalytic residues [active] 649831014991 metal binding site [ion binding]; metal-binding site 649831014992 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 649831014993 dimerization interface [polypeptide binding]; other site 649831014994 putative DNA binding site [nucleotide binding]; other site 649831014995 Transcriptional regulators [Transcription]; Region: MarR; COG1846 649831014996 putative Zn2+ binding site [ion binding]; other site 649831014997 H+ Antiporter protein; Region: 2A0121; TIGR00900 649831014998 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 649831014999 acyl-activating enzyme (AAE) consensus motif; other site 649831015000 AMP binding site [chemical binding]; other site 649831015001 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 649831015002 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 649831015003 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 649831015004 MbtH-like protein; Region: MbtH; cl01279 649831015005 Condensation domain; Region: Condensation; pfam00668 649831015006 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 649831015007 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 649831015008 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 649831015009 acyl-activating enzyme (AAE) consensus motif; other site 649831015010 AMP binding site [chemical binding]; other site 649831015011 active site 649831015012 CoA binding site [chemical binding]; other site 649831015013 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 649831015014 Condensation domain; Region: Condensation; pfam00668 649831015015 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 649831015016 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 649831015017 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 649831015018 acyl-activating enzyme (AAE) consensus motif; other site 649831015019 AMP binding site [chemical binding]; other site 649831015020 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 649831015021 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 649831015022 Condensation domain; Region: Condensation; pfam00668 649831015023 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 649831015024 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 649831015025 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 649831015026 acyl-activating enzyme (AAE) consensus motif; other site 649831015027 AMP binding site [chemical binding]; other site 649831015028 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 649831015029 Condensation domain; Region: Condensation; pfam00668 649831015030 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 649831015031 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 649831015032 acyl-activating enzyme (AAE) consensus motif; other site 649831015033 AMP binding site [chemical binding]; other site 649831015034 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 649831015035 Condensation domain; Region: Condensation; pfam00668 649831015036 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 649831015037 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 649831015038 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 649831015039 acyl-activating enzyme (AAE) consensus motif; other site 649831015040 AMP binding site [chemical binding]; other site 649831015041 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 649831015042 Condensation domain; Region: Condensation; pfam00668 649831015043 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 649831015044 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 649831015045 acyl-activating enzyme (AAE) consensus motif; other site 649831015046 AMP binding site [chemical binding]; other site 649831015047 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 649831015048 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 649831015049 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 649831015050 ATP binding site [chemical binding]; other site 649831015051 substrate interface [chemical binding]; other site 649831015052 MoeZ/MoeB domain; Region: MoeZ_MoeB; pfam05237 649831015053 putative pectinesterase; Region: PLN02432; cl01911 649831015054 Pectinesterase; Region: Pectinesterase; pfam01095 649831015055 Transcriptional regulators [Transcription]; Region: PurR; COG1609 649831015056 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 649831015057 DNA binding site [nucleotide binding] 649831015058 domain linker motif; other site 649831015059 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 649831015060 ligand binding site [chemical binding]; other site 649831015061 dimerization interface [polypeptide binding]; other site 649831015062 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 649831015063 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 649831015064 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 649831015065 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649831015066 dimer interface [polypeptide binding]; other site 649831015067 conserved gate region; other site 649831015068 putative PBP binding loops; other site 649831015069 ABC-ATPase subunit interface; other site 649831015070 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 649831015071 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649831015072 dimer interface [polypeptide binding]; other site 649831015073 conserved gate region; other site 649831015074 putative PBP binding loops; other site 649831015075 ABC-ATPase subunit interface; other site 649831015076 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 649831015077 beta-galactosidase; Region: BGL; TIGR03356 649831015078 Putative esterase; Region: Esterase; pfam00756 649831015079 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 649831015080 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 649831015081 active site 649831015082 catalytic triad [active] 649831015083 oxyanion hole [active] 649831015084 sucrose phosphorylase; Provisional; Region: PRK13840 649831015085 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 649831015086 active site 649831015087 catalytic site [active] 649831015088 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 649831015089 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649831015090 dimer interface [polypeptide binding]; other site 649831015091 conserved gate region; other site 649831015092 putative PBP binding loops; other site 649831015093 ABC-ATPase subunit interface; other site 649831015094 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649831015095 dimer interface [polypeptide binding]; other site 649831015096 conserved gate region; other site 649831015097 putative PBP binding loops; other site 649831015098 ABC-ATPase subunit interface; other site 649831015099 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 649831015100 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 649831015101 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 649831015102 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 649831015103 Transcriptional regulators [Transcription]; Region: PurR; COG1609 649831015104 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 649831015105 DNA binding site [nucleotide binding] 649831015106 domain linker motif; other site 649831015107 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 649831015108 ligand binding site [chemical binding]; other site 649831015109 dimerization interface [polypeptide binding]; other site 649831015110 Catalytic domain of Protein Kinases; Region: PKc; cd00180 649831015111 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 649831015112 active site 649831015113 ATP binding site [chemical binding]; other site 649831015114 substrate binding site [chemical binding]; other site 649831015115 activation loop (A-loop); other site 649831015116 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 649831015117 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 649831015118 Catalytic domain of Protein Kinases; Region: PKc; cd00180 649831015119 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 649831015120 active site 649831015121 ATP binding site [chemical binding]; other site 649831015122 substrate binding site [chemical binding]; other site 649831015123 activation loop (A-loop); other site 649831015124 Endoglucanase E-like members of the SGNH hydrolase family; Endoglucanase E catalyzes the endohydrolysis of 1,4-beta-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; Region: Endoglucanase_E_like; cd01831 649831015125 active site 649831015126 catalytic triad [active] 649831015127 oxyanion hole [active] 649831015128 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 649831015129 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 649831015130 putative NAD(P) binding site [chemical binding]; other site 649831015131 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 649831015132 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 649831015133 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 649831015134 metal binding site [ion binding]; metal-binding site 649831015135 active site 649831015136 I-site; other site 649831015137 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 649831015138 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 649831015139 Peptidase family M28; Region: Peptidase_M28; pfam04389 649831015140 metal binding site [ion binding]; metal-binding site 649831015141 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 649831015142 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 649831015143 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 649831015144 putative sugar binding sites [chemical binding]; other site 649831015145 Q-X-W motif; other site 649831015146 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 649831015147 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 649831015148 Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270 649831015149 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 649831015150 CBD_II domain; Region: CBD_II; smart00637 649831015151 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 649831015152 substrate binding site [chemical binding]; other site 649831015153 active site 649831015154 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 649831015155 metal binding site [ion binding]; metal-binding site 649831015156 ligand binding site [chemical binding]; other site 649831015157 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 649831015158 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 649831015159 putative sugar binding sites [chemical binding]; other site 649831015160 Q-X-W motif; other site 649831015161 Glycosyl hydrolase family 62; Region: Glyco_hydro_62; pfam03664 649831015162 active site 649831015163 Transcriptional regulators [Transcription]; Region: MarR; COG1846 649831015164 MarR family; Region: MarR_2; pfam12802 649831015165 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 649831015166 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 649831015167 sequence-specific DNA binding site [nucleotide binding]; other site 649831015168 salt bridge; other site 649831015169 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 649831015170 Catalytic domain of Protein Kinases; Region: PKc; cd00180 649831015171 active site 649831015172 ATP binding site [chemical binding]; other site 649831015173 substrate binding site [chemical binding]; other site 649831015174 activation loop (A-loop); other site 649831015175 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 649831015176 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 649831015177 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 649831015178 active site 649831015179 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 649831015180 active site 649831015181 NAD binding site [chemical binding]; other site 649831015182 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 649831015183 metal binding site [ion binding]; metal-binding site 649831015184 Transcriptional regulators [Transcription]; Region: GntR; COG1802 649831015185 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 649831015186 DNA-binding site [nucleotide binding]; DNA binding site 649831015187 FCD domain; Region: FCD; cl11656 649831015188 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 649831015189 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 649831015190 pyridoxal 5'-phosphate binding site [chemical binding]; other site 649831015191 catalytic residue [active] 649831015192 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 649831015193 Firmicute plasmid replication protein (RepL); Region: RepL; pfam05732 649831015194 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 649831015195 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 649831015196 Walker A/P-loop; other site 649831015197 ATP binding site [chemical binding]; other site 649831015198 Q-loop/lid; other site 649831015199 ABC transporter signature motif; other site 649831015200 Walker B; other site 649831015201 D-loop; other site 649831015202 H-loop/switch region; other site 649831015203 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 649831015204 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 649831015205 Zn binding site [ion binding]; other site 649831015206 Pectate lyase; Region: Pectate_lyase; pfam03211 649831015207 Amb_all domain; Region: Amb_all; smart00656 649831015208 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649831015209 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649831015210 DNA binding residues [nucleotide binding] 649831015211 dimerization interface [polypeptide binding]; other site 649831015212 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 649831015213 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 649831015214 active site 649831015215 Zn binding site [ion binding]; other site 649831015216 Four repeated domains in the Fasciclin I family of proteins, present in many other contexts; Region: FAS1; smart00554 649831015217 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 649831015218 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 649831015219 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 649831015220 DNA binding residues [nucleotide binding] 649831015221 Transcriptional regulators [Transcription]; Region: MarR; COG1846 649831015222 MarR family; Region: MarR_2; cl17246 649831015223 Transport protein; Region: actII; TIGR00833 649831015224 MMPL family; Region: MMPL; pfam03176 649831015225 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 649831015226 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 649831015227 Cupin superfamily protein; Region: Cupin_4; pfam08007 649831015228 Cupin-like domain; Region: Cupin_8; pfam13621 649831015229 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 649831015230 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 649831015231 acyl-activating enzyme (AAE) consensus motif; other site 649831015232 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 649831015233 AMP binding site [chemical binding]; other site 649831015234 active site 649831015235 acyl-activating enzyme (AAE) consensus motif; other site 649831015236 Phosphopantetheine attachment site; Region: PP-binding; cl09936 649831015237 Condensation domain; Region: Condensation; pfam00668 649831015238 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 649831015239 Peptidase C39 family; Region: Peptidase_C39; pfam03412 649831015240 putative active site [active] 649831015241 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649831015242 Walker A/P-loop; other site 649831015243 ATP binding site [chemical binding]; other site 649831015244 Q-loop/lid; other site 649831015245 ABC transporter signature motif; other site 649831015246 Walker B; other site 649831015247 D-loop; other site 649831015248 H-loop/switch region; other site 649831015249 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 649831015250 Cytochrome P450; Region: p450; cl12078 649831015251 asparagine synthetase A; Reviewed; Region: PRK06462 649831015252 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 649831015253 motif 1; other site 649831015254 dimer interface [polypeptide binding]; other site 649831015255 active site 649831015256 motif 2; other site 649831015257 motif 3; other site 649831015258 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 649831015259 anticodon binding site; other site 649831015260 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 649831015261 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 649831015262 active site 649831015263 nucleotide binding site [chemical binding]; other site 649831015264 HIGH motif; other site 649831015265 KMSKS motif; other site 649831015266 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 649831015267 tRNA binding surface [nucleotide binding]; other site 649831015268 anticodon binding site; other site 649831015269 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 649831015270 putative dimer interface [polypeptide binding]; other site 649831015271 catalytic triad [active] 649831015272 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 649831015273 Ligand Binding Site [chemical binding]; other site 649831015274 Methyltransferase domain; Region: Methyltransf_31; pfam13847 649831015275 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649831015276 S-adenosylmethionine binding site [chemical binding]; other site 649831015277 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 649831015278 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 649831015279 pyridoxal 5'-phosphate binding site [chemical binding]; other site 649831015280 homodimer interface [polypeptide binding]; other site 649831015281 catalytic residue [active] 649831015282 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 649831015283 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 649831015284 binding surface 649831015285 TPR motif; other site 649831015286 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 649831015287 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 649831015288 acyl-activating enzyme (AAE) consensus motif; other site 649831015289 AMP binding site [chemical binding]; other site 649831015290 active site 649831015291 CoA binding site [chemical binding]; other site 649831015292 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831015293 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 649831015294 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831015295 active site 649831015296 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 649831015297 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 649831015298 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 649831015299 natural product biosynthesis luciferase-like monooxygenase domain; Region: seco_metab_LLM; TIGR04020 649831015300 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 649831015301 Condensation domain; Region: Condensation; pfam00668 649831015302 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 649831015303 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 649831015304 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 649831015305 acyl-activating enzyme (AAE) consensus motif; other site 649831015306 AMP binding site [chemical binding]; other site 649831015307 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 649831015308 Condensation domain; Region: Condensation; pfam00668 649831015309 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 649831015310 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 649831015311 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649831015312 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649831015313 DNA binding residues [nucleotide binding] 649831015314 dimerization interface [polypeptide binding]; other site 649831015315 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 649831015316 active site 649831015317 catalytic residues [active] 649831015318 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 649831015319 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 649831015320 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 649831015321 Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721 649831015322 Cna protein B-type domain; Region: Cna_B_2; pfam13715 649831015323 Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721 649831015324 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 649831015325 Amidohydrolase; Region: Amidohydro_2; pfam04909 649831015326 Right handed beta helix region; Region: Beta_helix; pfam13229 649831015327 Cellulose binding domain; Region: CBM_2; pfam00553 649831015328 Cellulose binding domain; Region: CBM_2; pfam00553 649831015329 Alpha-L-arabinofuranosidase B, catalytic; Region: ArabFuran-catal; pfam09206 649831015330 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 649831015331 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 649831015332 ligand binding site [chemical binding]; other site 649831015333 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 649831015334 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 649831015335 Walker A/P-loop; other site 649831015336 ATP binding site [chemical binding]; other site 649831015337 Q-loop/lid; other site 649831015338 ABC transporter signature motif; other site 649831015339 Walker B; other site 649831015340 D-loop; other site 649831015341 H-loop/switch region; other site 649831015342 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 649831015343 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 649831015344 TM-ABC transporter signature motif; other site 649831015345 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 649831015346 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 649831015347 metal binding site [ion binding]; metal-binding site 649831015348 substrate binding pocket [chemical binding]; other site 649831015349 Transcriptional regulators [Transcription]; Region: FadR; COG2186 649831015350 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 649831015351 DNA-binding site [nucleotide binding]; DNA binding site 649831015352 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 649831015353 Transcriptional regulators [Transcription]; Region: FadR; COG2186 649831015354 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 649831015355 DNA-binding site [nucleotide binding]; DNA binding site 649831015356 FCD domain; Region: FCD; pfam07729 649831015357 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 649831015358 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 649831015359 active site 649831015360 catalytic tetrad [active] 649831015361 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 649831015362 Amidohydrolase; Region: Amidohydro_2; pfam04909 649831015363 active site 649831015364 Domain of unknown function (DUF718); Region: DUF718; pfam05336 649831015365 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 649831015366 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 649831015367 active site pocket [active] 649831015368 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 649831015369 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 649831015370 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 649831015371 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 649831015372 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 649831015373 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 649831015374 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 649831015375 NAD(P) binding site [chemical binding]; other site 649831015376 2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832 649831015377 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831015378 NAD(P) binding site [chemical binding]; other site 649831015379 active site 649831015380 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 649831015381 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 649831015382 active site 649831015383 intersubunit interface [polypeptide binding]; other site 649831015384 catalytic residue [active] 649831015385 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 649831015386 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 649831015387 substrate binding site [chemical binding]; other site 649831015388 ATP binding site [chemical binding]; other site 649831015389 Cupin domain; Region: Cupin_2; pfam07883 649831015390 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 649831015391 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 649831015392 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 649831015393 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 649831015394 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 649831015395 active site 649831015396 Zn binding site [ion binding]; other site 649831015397 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 649831015398 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 649831015399 glycosyltransferase, MSMEG_0565 family; Region: MSMEG_0565_glyc; TIGR04047 649831015400 Predicted amidohydrolase [General function prediction only]; Region: COG0388 649831015401 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 649831015402 active site 649831015403 catalytic triad [active] 649831015404 dimer interface [polypeptide binding]; other site 649831015405 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 649831015406 Predicted amidohydrolase [General function prediction only]; Region: COG0388 649831015407 active site 649831015408 catalytic triad [active] 649831015409 dimer interface [polypeptide binding]; other site 649831015410 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 649831015411 Coenzyme A binding pocket [chemical binding]; other site 649831015412 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 649831015413 AIR synthase-related protein, MSMEG_0567 C-terminal family; Region: MSMEG_0567_Cter; TIGR04050 649831015414 dimerization interface [polypeptide binding]; other site 649831015415 ATP binding site [chemical binding]; other site 649831015416 radical SAM protein, MSMEG_0568 family; Region: rSAM_MSMEG_0568; TIGR04043 649831015417 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 649831015418 FeS/SAM binding site; other site 649831015419 MSMEG_0572 family protein; Region: MSMEG_0572_fam; TIGR04044 649831015420 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 649831015421 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 649831015422 active site 649831015423 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 649831015424 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 649831015425 MSMEG_0570 family protein; Region: MSMEG_0570_fam; TIGR04042 649831015426 Thiopurine S-methyltransferase (TPMT); Region: TPMT; pfam05724 649831015427 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649831015428 S-adenosylmethionine binding site [chemical binding]; other site 649831015429 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 649831015430 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 649831015431 shikimate binding site; other site 649831015432 NAD(P) binding site [chemical binding]; other site 649831015433 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 649831015434 Dehydroquinase class II; Region: DHquinase_II; pfam01220 649831015435 active site 649831015436 trimer interface [polypeptide binding]; other site 649831015437 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 649831015438 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 649831015439 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 649831015440 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 649831015441 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 649831015442 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 649831015443 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 649831015444 3-amino-5-hydroxybenoic acid synthesis related protein; Region: AHBA_synth_RP; TIGR01454 649831015445 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 649831015446 motif II; other site 649831015447 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 649831015448 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 649831015449 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 649831015450 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 649831015451 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 649831015452 inhibitor-cofactor binding pocket; inhibition site 649831015453 pyridoxal 5'-phosphate binding site [chemical binding]; other site 649831015454 catalytic residue [active] 649831015455 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 649831015456 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 649831015457 active site 649831015458 dimer interface [polypeptide binding]; other site 649831015459 metal binding site [ion binding]; metal-binding site 649831015460 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 649831015461 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 649831015462 acyl-activating enzyme (AAE) consensus motif; other site 649831015463 AMP binding site [chemical binding]; other site 649831015464 active site 649831015465 CoA binding site [chemical binding]; other site 649831015466 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831015467 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831015468 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 649831015469 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831015470 active site 649831015471 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 649831015472 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 649831015473 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 649831015474 putative NADP binding site [chemical binding]; other site 649831015475 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 649831015476 active site 649831015477 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831015478 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831015479 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 649831015480 active site 649831015481 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 649831015482 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 649831015483 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831015484 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 649831015485 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831015486 active site 649831015487 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 649831015488 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 649831015489 KR domain; Region: KR; pfam08659 649831015490 NADP binding site [chemical binding]; other site 649831015491 active site 649831015492 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831015493 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649831015494 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649831015495 DNA binding residues [nucleotide binding] 649831015496 dimerization interface [polypeptide binding]; other site 649831015497 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 649831015498 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 649831015499 active site 649831015500 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 649831015501 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 649831015502 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831015503 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 649831015504 NAD(P) binding site [chemical binding]; other site 649831015505 active site 649831015506 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 649831015507 CoA-transferase family III; Region: CoA_transf_3; pfam02515 649831015508 Predicted flavoprotein [General function prediction only]; Region: COG0431 649831015509 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 649831015510 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 649831015511 Zeta-crystallin with NADP-dependent quinone reductase activity (QOR); Region: zeta_crystallin; cd08253 649831015512 NAD(P) binding site [chemical binding]; other site 649831015513 acyltransferase PapA5; Provisional; Region: PRK09294 649831015514 N-acetyltransferase; Region: Acetyltransf_2; cl00949 649831015515 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 649831015516 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831015517 active site 649831015518 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 649831015519 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 649831015520 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 649831015521 putative NADP binding site [chemical binding]; other site 649831015522 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 649831015523 active site 649831015524 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831015525 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 649831015526 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831015527 active site 649831015528 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 649831015529 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 649831015530 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 649831015531 putative NADP binding site [chemical binding]; other site 649831015532 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 649831015533 active site 649831015534 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831015535 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 649831015536 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831015537 active site 649831015538 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 649831015539 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 649831015540 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831015541 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 649831015542 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 649831015543 Cytochrome P450; Region: p450; cl12078 649831015544 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 649831015545 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649831015546 S-adenosylmethionine binding site [chemical binding]; other site 649831015547 MbtH-like protein; Region: MbtH; smart00923 649831015548 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 649831015549 Cytochrome P450; Region: p450; cl12078 649831015550 acyl-CoA synthetase; Validated; Region: PRK06188 649831015551 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 649831015552 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 649831015553 acyl-activating enzyme (AAE) consensus motif; other site 649831015554 acyl-activating enzyme (AAE) consensus motif; other site 649831015555 AMP binding site [chemical binding]; other site 649831015556 active site 649831015557 CoA binding site [chemical binding]; other site 649831015558 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 649831015559 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 649831015560 acyl-activating enzyme (AAE) consensus motif; other site 649831015561 AMP binding site [chemical binding]; other site 649831015562 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 649831015563 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 649831015564 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649831015565 S-adenosylmethionine binding site [chemical binding]; other site 649831015566 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 649831015567 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 649831015568 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 649831015569 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 649831015570 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 649831015571 Cytochrome P450; Region: p450; cl12078 649831015572 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 649831015573 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 649831015574 NAD(P) binding site [chemical binding]; other site 649831015575 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 649831015576 dimerization interface [polypeptide binding]; other site 649831015577 putative DNA binding site [nucleotide binding]; other site 649831015578 putative Zn2+ binding site [ion binding]; other site 649831015579 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 649831015580 putative DNA binding site [nucleotide binding]; other site 649831015581 dimerization interface [polypeptide binding]; other site 649831015582 putative Zn2+ binding site [ion binding]; other site 649831015583 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 649831015584 arsenical-resistance protein; Region: acr3; TIGR00832 649831015585 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 649831015586 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 649831015587 dimer interface [polypeptide binding]; other site 649831015588 phosphorylation site [posttranslational modification] 649831015589 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831015590 ATP binding site [chemical binding]; other site 649831015591 Mg2+ binding site [ion binding]; other site 649831015592 G-X-G motif; other site 649831015593 Response regulator receiver domain; Region: Response_reg; pfam00072 649831015594 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831015595 active site 649831015596 phosphorylation site [posttranslational modification] 649831015597 intermolecular recognition site; other site 649831015598 dimerization interface [polypeptide binding]; other site 649831015599 Protein of unknown function C-terminus (DUF2399); Region: DUF2399; pfam09664 649831015600 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 649831015601 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831015602 active site 649831015603 phosphorylation site [posttranslational modification] 649831015604 intermolecular recognition site; other site 649831015605 dimerization interface [polypeptide binding]; other site 649831015606 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 649831015607 DNA binding site [nucleotide binding] 649831015608 Anabaena sensory rhodopsin transducer; Region: ASRT; cl01751 649831015609 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 649831015610 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 649831015611 dimerization interface [polypeptide binding]; other site 649831015612 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 649831015613 dimer interface [polypeptide binding]; other site 649831015614 phosphorylation site [posttranslational modification] 649831015615 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831015616 ATP binding site [chemical binding]; other site 649831015617 Mg2+ binding site [ion binding]; other site 649831015618 G-X-G motif; other site 649831015619 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 649831015620 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 649831015621 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 649831015622 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 649831015623 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 649831015624 DDE superfamily endonuclease; Region: DDE_5; pfam13546 649831015625 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 649831015626 active site 649831015627 Int/Topo IB signature motif; other site 649831015628 DDE superfamily endonuclease; Region: DDE_5; pfam13546 649831015629 AAA ATPase domain; Region: AAA_16; pfam13191 649831015630 CHASE3 domain; Region: CHASE3; pfam05227 649831015631 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 649831015632 substrate binding site [chemical binding]; other site 649831015633 activation loop (A-loop); other site 649831015634 AAA domain; Region: AAA_11; pfam13086 649831015635 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 649831015636 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 649831015637 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831015638 ATP binding site [chemical binding]; other site 649831015639 Mg2+ binding site [ion binding]; other site 649831015640 G-X-G motif; other site 649831015641 Tetratricopeptide repeat; Region: TPR_12; pfam13424 649831015642 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 649831015643 TPR motif; other site 649831015644 binding surface 649831015645 Tetratricopeptide repeat; Region: TPR_12; pfam13424 649831015646 CHAT domain; Region: CHAT; pfam12770 649831015647 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 649831015648 nucleotide binding site [chemical binding]; other site 649831015649 primase nucleotide-binding site [nucleotide binding]; other site 649831015650 DNA-binding residues [nucleotide binding]; DNA binding site 649831015651 Primase C terminal 1 (PriCT-1); Region: PriCT_1; cl07362 649831015652 AAA domain; Region: AAA_25; pfam13481 649831015653 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 649831015654 Walker A motif; other site 649831015655 ATP binding site [chemical binding]; other site 649831015656 Walker B motif; other site 649831015657 MarR family; Region: MarR_2; pfam12802 649831015658 Helix-turn-helix domain; Region: HTH_17; cl17695 649831015659 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 649831015660 active site 649831015661 catalytic residues [active] 649831015662 DNA binding site [nucleotide binding] 649831015663 Int/Topo IB signature motif; other site 649831015664 ribosome-associated GTPase EngA; Region: GTPase_EngA; TIGR03594 649831015665 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 649831015666 GTP/Mg2+ binding site [chemical binding]; other site 649831015667 G1 box; other site 649831015668 Switch I region; other site 649831015669 G2 box; other site 649831015670 Switch II region; other site 649831015671 G3 box; other site 649831015672 G4 box; other site 649831015673 G5 box; other site 649831015674 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 649831015675 G1 box; other site 649831015676 GTP/Mg2+ binding site [chemical binding]; other site 649831015677 Switch I region; other site 649831015678 G2 box; other site 649831015679 G3 box; other site 649831015680 Switch II region; other site 649831015681 G4 box; other site 649831015682 G5 box; other site 649831015683 cytidylate kinase; Provisional; Region: cmk; PRK00023 649831015684 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 649831015685 CMP-binding site; other site 649831015686 The sites determining sugar specificity; other site 649831015687 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 649831015688 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 649831015689 RNA binding surface [nucleotide binding]; other site 649831015690 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 649831015691 active site 649831015692 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 649831015693 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 649831015694 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 649831015695 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 649831015696 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 649831015697 DNA binding residues [nucleotide binding] 649831015698 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 649831015699 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831015700 Domain of unknown function (DUF1877); Region: DUF1877; pfam08974 649831015701 Isochorismatase family; Region: Isochorismatase; pfam00857 649831015702 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 649831015703 catalytic triad [active] 649831015704 conserved cis-peptide bond; other site 649831015705 Uncharacterized conserved protein (DUF2228); Region: DUF2228; pfam10228 649831015706 Predicted transcriptional regulators [Transcription]; Region: COG1695 649831015707 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 649831015708 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 649831015709 putative substrate binding region [chemical binding]; other site 649831015710 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 649831015711 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 649831015712 P-loop; other site 649831015713 Magnesium ion binding site [ion binding]; other site 649831015714 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 649831015715 Magnesium ion binding site [ion binding]; other site 649831015716 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 649831015717 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 649831015718 active site 649831015719 DNA binding site [nucleotide binding] 649831015720 Int/Topo IB signature motif; other site 649831015721 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 649831015722 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 649831015723 hexamer interface [polypeptide binding]; other site 649831015724 ligand binding site [chemical binding]; other site 649831015725 putative active site [active] 649831015726 NAD(P) binding site [chemical binding]; other site 649831015727 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 649831015728 classical (c) SDRs; Region: SDR_c; cd05233 649831015729 NAD(P) binding site [chemical binding]; other site 649831015730 active site 649831015731 RDD family; Region: RDD; pfam06271 649831015732 short chain dehydrogenase; Provisional; Region: PRK06180 649831015733 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 649831015734 NADP binding site [chemical binding]; other site 649831015735 active site 649831015736 steroid binding site; other site 649831015737 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 649831015738 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 649831015739 dimerization interface [polypeptide binding]; other site 649831015740 substrate binding pocket [chemical binding]; other site 649831015741 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 649831015742 Cellulose binding domain; Region: CBM_2; pfam00553 649831015743 patatin-related protein; Region: TIGR03607 649831015744 Patatin-like phospholipase; Region: Patatin; pfam01734 649831015745 choline dehydrogenase; Region: betA; TIGR01810 649831015746 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 649831015747 alpha-dioxygenase; Region: PLN02283 649831015748 Animal heme oxidases similar to plant pathogen-inducible oxygenases; Region: PIOX_like; cd09818 649831015749 putative heme binding site [chemical binding]; other site 649831015750 putative active site [active] 649831015751 putative substrate binding site [chemical binding]; other site 649831015752 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 649831015753 active site 649831015754 nucleophile elbow; other site 649831015755 Domain of unknown function (DUF4331); Region: DUF4331; pfam14224 649831015756 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 649831015757 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 649831015758 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 649831015759 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 649831015760 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 649831015761 Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_euk_AmyA; cd11317 649831015762 active site 649831015763 Ca binding site [ion binding]; other site 649831015764 catalytic site [active] 649831015765 Aamy_C domain; Region: Aamy_C; smart00632 649831015766 The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cl15347 649831015767 starch-binding site 2 [chemical binding]; other site 649831015768 starch-binding site 1 [chemical binding]; other site 649831015769 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 649831015770 dimer interface [polypeptide binding]; other site 649831015771 active site 649831015772 ADP-ribose binding site [chemical binding]; other site 649831015773 nudix motif; other site 649831015774 metal binding site [ion binding]; metal-binding site 649831015775 CTP synthetase; Validated; Region: pyrG; PRK05380 649831015776 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 649831015777 Catalytic site [active] 649831015778 active site 649831015779 UTP binding site [chemical binding]; other site 649831015780 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 649831015781 active site 649831015782 putative oxyanion hole; other site 649831015783 catalytic triad [active] 649831015784 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 649831015785 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 649831015786 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 649831015787 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 649831015788 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 649831015789 Thiamine pyrophosphokinase; Region: TPK; cl08415 649831015790 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 649831015791 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 649831015792 Walker A/P-loop; other site 649831015793 ATP binding site [chemical binding]; other site 649831015794 Q-loop/lid; other site 649831015795 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 649831015796 ABC transporter signature motif; other site 649831015797 Walker B; other site 649831015798 D-loop; other site 649831015799 H-loop/switch region; other site 649831015800 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 649831015801 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708 649831015802 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 649831015803 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 649831015804 RNA binding surface [nucleotide binding]; other site 649831015805 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649831015806 S-adenosylmethionine binding site [chemical binding]; other site 649831015807 Uncharacterized conserved protein [Function unknown]; Region: COG3937 649831015808 SCP-2 sterol transfer family; Region: SCP2; pfam02036 649831015809 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 649831015810 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 649831015811 active site 649831015812 motif I; other site 649831015813 motif II; other site 649831015814 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 649831015815 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 649831015816 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 649831015817 active site 649831015818 HIGH motif; other site 649831015819 dimer interface [polypeptide binding]; other site 649831015820 KMSKS motif; other site 649831015821 S4 RNA-binding domain; Region: S4; smart00363 649831015822 RNA binding surface [nucleotide binding]; other site 649831015823 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 649831015824 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649831015825 S-adenosylmethionine binding site [chemical binding]; other site 649831015826 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 649831015827 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 649831015828 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 649831015829 adenylate kinase; Region: adk; TIGR01351 649831015830 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 649831015831 AMP-binding site [chemical binding]; other site 649831015832 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 649831015833 PemK-like protein; Region: PemK; pfam02452 649831015834 TM1410 hypothetical-related protein; Region: DUF297; pfam03537 649831015835 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 649831015836 FOG: CBS domain [General function prediction only]; Region: COG0517 649831015837 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 649831015838 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 649831015839 active site 649831015840 DNA binding site [nucleotide binding] 649831015841 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649831015842 S-adenosylmethionine binding site [chemical binding]; other site 649831015843 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 649831015844 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 649831015845 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831015846 hypothetical protein; Provisional; Region: PRK08244 649831015847 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 649831015848 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 649831015849 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 649831015850 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 649831015851 Predicted transcriptional regulators [Transcription]; Region: COG1733 649831015852 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 649831015853 Protein of unknown function (DUF4240); Region: DUF4240; pfam14024 649831015854 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 649831015855 hydrophobic ligand binding site; other site 649831015856 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 649831015857 putative substrate binding site [chemical binding]; other site 649831015858 putative ATP binding site [chemical binding]; other site 649831015859 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 649831015860 catalytic core [active] 649831015861 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 649831015862 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 649831015863 metal binding site [ion binding]; metal-binding site 649831015864 active site 649831015865 I-site; other site 649831015866 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 649831015867 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 649831015868 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 649831015869 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649831015870 dimer interface [polypeptide binding]; other site 649831015871 conserved gate region; other site 649831015872 putative PBP binding loops; other site 649831015873 ABC-ATPase subunit interface; other site 649831015874 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 649831015875 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649831015876 dimer interface [polypeptide binding]; other site 649831015877 conserved gate region; other site 649831015878 putative PBP binding loops; other site 649831015879 ABC-ATPase subunit interface; other site 649831015880 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 649831015881 HNH/ENDO VII superfamily nuclease with conserved GHE residues; Region: GH-E; pfam14410 649831015882 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 649831015883 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 649831015884 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 649831015885 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 649831015886 dimerization interface [polypeptide binding]; other site 649831015887 substrate binding pocket [chemical binding]; other site 649831015888 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 649831015889 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 649831015890 argininosuccinate lyase; Provisional; Region: PRK00855 649831015891 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 649831015892 active sites [active] 649831015893 tetramer interface [polypeptide binding]; other site 649831015894 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 649831015895 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 649831015896 metal binding site [ion binding]; metal-binding site 649831015897 putative dimer interface [polypeptide binding]; other site 649831015898 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 649831015899 Ligand Binding Site [chemical binding]; other site 649831015900 arginine repressor; Provisional; Region: PRK03341 649831015901 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 649831015902 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 649831015903 ornithine carbamoyltransferase; Provisional; Region: PRK00779 649831015904 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 649831015905 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 649831015906 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 649831015907 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 649831015908 inhibitor-cofactor binding pocket; inhibition site 649831015909 pyridoxal 5'-phosphate binding site [chemical binding]; other site 649831015910 catalytic residue [active] 649831015911 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 649831015912 feedback inhibition sensing region; other site 649831015913 homohexameric interface [polypeptide binding]; other site 649831015914 nucleotide binding site [chemical binding]; other site 649831015915 N-acetyl-L-glutamate binding site [chemical binding]; other site 649831015916 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 649831015917 heterotetramer interface [polypeptide binding]; other site 649831015918 active site pocket [active] 649831015919 cleavage site 649831015920 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 649831015921 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 649831015922 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 649831015923 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 649831015924 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 649831015925 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK06830 649831015926 6-phosphofructokinase; Region: PLN02884 649831015927 active site 649831015928 ADP/pyrophosphate binding site [chemical binding]; other site 649831015929 dimerization interface [polypeptide binding]; other site 649831015930 allosteric effector site; other site 649831015931 fructose-1,6-bisphosphate binding site; other site 649831015932 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 649831015933 putative active site [active] 649831015934 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 649831015935 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649831015936 ABC transporter signature motif; other site 649831015937 Walker B; other site 649831015938 D-loop; other site 649831015939 H-loop/switch region; other site 649831015940 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 649831015941 endoglucanase; Region: PLN02308 649831015942 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759 649831015943 Cellulose binding domain; Region: CBM_3; smart01067 649831015944 Cellulose binding domain; Region: CBM_2; pfam00553 649831015945 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 649831015946 metal binding site [ion binding]; metal-binding site 649831015947 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 649831015948 Interdomain contacts; other site 649831015949 Part of AAA domain; Region: AAA_19; pfam13245 649831015950 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 649831015951 AAA domain; Region: AAA_12; pfam13087 649831015952 Uncharacterized conserved protein [Function unknown]; Region: COG1359 649831015953 Protein of unknown function (DUF664); Region: DUF664; pfam04978 649831015954 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; cl17774 649831015955 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 649831015956 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 649831015957 salt bridge; other site 649831015958 non-specific DNA binding site [nucleotide binding]; other site 649831015959 sequence-specific DNA binding site [nucleotide binding]; other site 649831015960 putative NAD(P)-binding oxidoreductase; Provisional; Region: PRK09730 649831015961 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831015962 NAD(P) binding site [chemical binding]; other site 649831015963 active site 649831015964 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 649831015965 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 649831015966 putative tRNA-binding site [nucleotide binding]; other site 649831015967 B3/4 domain; Region: B3_4; pfam03483 649831015968 tRNA synthetase B5 domain; Region: B5; smart00874 649831015969 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 649831015970 dimer interface [polypeptide binding]; other site 649831015971 motif 1; other site 649831015972 motif 3; other site 649831015973 motif 2; other site 649831015974 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 649831015975 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 649831015976 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 649831015977 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 649831015978 dimer interface [polypeptide binding]; other site 649831015979 motif 1; other site 649831015980 active site 649831015981 motif 2; other site 649831015982 motif 3; other site 649831015983 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 649831015984 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 649831015985 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 649831015986 23S rRNA binding site [nucleotide binding]; other site 649831015987 L21 binding site [polypeptide binding]; other site 649831015988 L13 binding site [polypeptide binding]; other site 649831015989 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 649831015990 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 649831015991 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 649831015992 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 649831015993 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 649831015994 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 649831015995 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 649831015996 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 649831015997 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 649831015998 homodimer interface [polypeptide binding]; other site 649831015999 putative metal binding site [ion binding]; other site 649831016000 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 649831016001 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 649831016002 substrate binding pocket [chemical binding]; other site 649831016003 membrane-bound complex binding site; other site 649831016004 hinge residues; other site 649831016005 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 649831016006 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 649831016007 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649831016008 dimer interface [polypeptide binding]; other site 649831016009 conserved gate region; other site 649831016010 putative PBP binding loops; other site 649831016011 ABC-ATPase subunit interface; other site 649831016012 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 649831016013 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 649831016014 Walker A/P-loop; other site 649831016015 ATP binding site [chemical binding]; other site 649831016016 Q-loop/lid; other site 649831016017 ABC transporter signature motif; other site 649831016018 Walker B; other site 649831016019 D-loop; other site 649831016020 H-loop/switch region; other site 649831016021 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 649831016022 homopentamer interface [polypeptide binding]; other site 649831016023 active site 649831016024 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 649831016025 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 649831016026 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 649831016027 dimerization interface [polypeptide binding]; other site 649831016028 active site 649831016029 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 649831016030 Lumazine binding domain; Region: Lum_binding; pfam00677 649831016031 Lumazine binding domain; Region: Lum_binding; pfam00677 649831016032 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 649831016033 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 649831016034 catalytic motif [active] 649831016035 Zn binding site [ion binding]; other site 649831016036 RibD C-terminal domain; Region: RibD_C; cl17279 649831016037 Response regulator receiver domain; Region: Response_reg; pfam00072 649831016038 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831016039 active site 649831016040 phosphorylation site [posttranslational modification] 649831016041 intermolecular recognition site; other site 649831016042 dimerization interface [polypeptide binding]; other site 649831016043 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 649831016044 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 649831016045 metal binding site [ion binding]; metal-binding site 649831016046 active site 649831016047 I-site; other site 649831016048 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 649831016049 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 649831016050 substrate binding site [chemical binding]; other site 649831016051 hexamer interface [polypeptide binding]; other site 649831016052 metal binding site [ion binding]; metal-binding site 649831016053 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 649831016054 16S rRNA methyltransferase B; Provisional; Region: PRK14902 649831016055 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649831016056 S-adenosylmethionine binding site [chemical binding]; other site 649831016057 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 649831016058 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 649831016059 putative active site [active] 649831016060 substrate binding site [chemical binding]; other site 649831016061 putative cosubstrate binding site; other site 649831016062 catalytic site [active] 649831016063 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 649831016064 substrate binding site [chemical binding]; other site 649831016065 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 649831016066 active site 649831016067 catalytic residues [active] 649831016068 metal binding site [ion binding]; metal-binding site 649831016069 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 649831016070 Cytochrome P450; Region: p450; cl12078 649831016071 Cytochrome P450; Region: p450; cl12078 649831016072 primosome assembly protein PriA; Provisional; Region: PRK14873 649831016073 S-adenosylmethionine synthetase; Validated; Region: PRK05250 649831016074 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 649831016075 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 649831016076 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 649831016077 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 649831016078 Flavoprotein; Region: Flavoprotein; pfam02441 649831016079 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 649831016080 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 649831016081 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 649831016082 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 649831016083 catalytic site [active] 649831016084 G-X2-G-X-G-K; other site 649831016085 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 649831016086 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 649831016087 active site 649831016088 dimer interface [polypeptide binding]; other site 649831016089 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 649831016090 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 649831016091 quinone interaction residues [chemical binding]; other site 649831016092 active site 649831016093 catalytic residues [active] 649831016094 FMN binding site [chemical binding]; other site 649831016095 substrate binding site [chemical binding]; other site 649831016096 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 649831016097 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 649831016098 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 649831016099 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 649831016100 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 649831016101 ATP-grasp domain; Region: ATP-grasp_4; cl17255 649831016102 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 649831016103 IMP binding site; other site 649831016104 dimer interface [polypeptide binding]; other site 649831016105 interdomain contacts; other site 649831016106 partial ornithine binding site; other site 649831016107 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 649831016108 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 649831016109 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 649831016110 catalytic site [active] 649831016111 subunit interface [polypeptide binding]; other site 649831016112 dihydroorotase; Validated; Region: pyrC; PRK09357 649831016113 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 649831016114 active site 649831016115 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 649831016116 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 649831016117 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 649831016118 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 649831016119 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 649831016120 active site 649831016121 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 649831016122 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 649831016123 non-specific DNA binding site [nucleotide binding]; other site 649831016124 salt bridge; other site 649831016125 sequence-specific DNA binding site [nucleotide binding]; other site 649831016126 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 649831016127 putative RNA binding site [nucleotide binding]; other site 649831016128 elongation factor P; Validated; Region: PRK00529 649831016129 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 649831016130 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 649831016131 RNA binding site [nucleotide binding]; other site 649831016132 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 649831016133 RNA binding site [nucleotide binding]; other site 649831016134 Dehydroquinase class II; Region: DHquinase_II; pfam01220 649831016135 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 649831016136 trimer interface [polypeptide binding]; other site 649831016137 active site 649831016138 dimer interface [polypeptide binding]; other site 649831016139 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 649831016140 dimer interface [polypeptide binding]; other site 649831016141 active site 649831016142 metal binding site [ion binding]; metal-binding site 649831016143 Clp amino terminal domain; Region: Clp_N; pfam02861 649831016144 Clp amino terminal domain; Region: Clp_N; pfam02861 649831016145 shikimate kinase; Reviewed; Region: aroK; PRK00131 649831016146 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 649831016147 ADP binding site [chemical binding]; other site 649831016148 magnesium binding site [ion binding]; other site 649831016149 putative shikimate binding site; other site 649831016150 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 649831016151 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 649831016152 Tetramer interface [polypeptide binding]; other site 649831016153 active site 649831016154 FMN-binding site [chemical binding]; other site 649831016155 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 649831016156 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 649831016157 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 649831016158 NAD(P) binding site [chemical binding]; other site 649831016159 shikimate binding site; other site 649831016160 YceG-like family; Region: YceG; pfam02618 649831016161 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 649831016162 dimerization interface [polypeptide binding]; other site 649831016163 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 649831016164 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 649831016165 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 649831016166 motif 1; other site 649831016167 active site 649831016168 motif 2; other site 649831016169 motif 3; other site 649831016170 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 649831016171 recombination factor protein RarA; Reviewed; Region: PRK13342 649831016172 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 649831016173 Walker A motif; other site 649831016174 ATP binding site [chemical binding]; other site 649831016175 Walker B motif; other site 649831016176 arginine finger; other site 649831016177 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 649831016178 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831016179 Major Facilitator Superfamily; Region: MFS_1; pfam07690 649831016180 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 649831016181 putative DNA binding site [nucleotide binding]; other site 649831016182 putative Zn2+ binding site [ion binding]; other site 649831016183 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 649831016184 Coenzyme A binding pocket [chemical binding]; other site 649831016185 Protein of unknown function (DUF4243); Region: DUF4243; pfam14027 649831016186 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 649831016187 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 649831016188 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831016189 NAD(P) binding site [chemical binding]; other site 649831016190 active site 649831016191 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 649831016192 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 649831016193 dimer interface [polypeptide binding]; other site 649831016194 anticodon binding site; other site 649831016195 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 649831016196 homodimer interface [polypeptide binding]; other site 649831016197 motif 1; other site 649831016198 active site 649831016199 motif 2; other site 649831016200 GAD domain; Region: GAD; pfam02938 649831016201 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 649831016202 motif 3; other site 649831016203 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 649831016204 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 649831016205 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 649831016206 AsnC family; Region: AsnC_trans_reg; pfam01037 649831016207 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831016208 Major Facilitator Superfamily; Region: MFS_1; pfam07690 649831016209 putative substrate translocation pore; other site 649831016210 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 649831016211 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 649831016212 non-specific DNA binding site [nucleotide binding]; other site 649831016213 salt bridge; other site 649831016214 sequence-specific DNA binding site [nucleotide binding]; other site 649831016215 Domain of unknown function (DUF397); Region: DUF397; pfam04149 649831016216 Helix-turn-helix domain; Region: HTH_17; cl17695 649831016217 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 649831016218 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 649831016219 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 649831016220 Phage capsid family; Region: Phage_capsid; pfam05065 649831016221 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 649831016222 oligomer interface [polypeptide binding]; other site 649831016223 Clp protease; Region: CLP_protease; pfam00574 649831016224 active site residues [active] 649831016225 Phage-related protein [Function unknown]; Region: COG4695 649831016226 Phage portal protein; Region: Phage_portal; pfam04860 649831016227 Phage Terminase; Region: Terminase_1; pfam03354 649831016228 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 649831016229 putative DNA binding site [nucleotide binding]; other site 649831016230 dimerization interface [polypeptide binding]; other site 649831016231 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 649831016232 non-specific DNA binding site [nucleotide binding]; other site 649831016233 salt bridge; other site 649831016234 sequence-specific DNA binding site [nucleotide binding]; other site 649831016235 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cl17280 649831016236 active site 649831016237 putative DNA-binding cleft [nucleotide binding]; other site 649831016238 dimer interface [polypeptide binding]; other site 649831016239 PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684 649831016240 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 649831016241 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 649831016242 catalytic residues [active] 649831016243 catalytic nucleophile [active] 649831016244 Recombinase; Region: Recombinase; pfam07508 649831016245 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 649831016246 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895 649831016247 Tetratrico peptide repeat; Region: TPR_5; pfam12688 649831016248 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 649831016249 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 649831016250 DNA binding residues [nucleotide binding] 649831016251 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 649831016252 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 649831016253 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 649831016254 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 649831016255 catalytic residue [active] 649831016256 dihydroorotase; Provisional; Region: PRK09237 649831016257 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 649831016258 active site 649831016259 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 649831016260 homotrimer interaction site [polypeptide binding]; other site 649831016261 putative active site [active] 649831016262 Integrase core domain; Region: rve; pfam00665 649831016263 Integrase core domain; Region: rve_3; pfam13683 649831016264 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 649831016265 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 649831016266 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 649831016267 putative active site [active] 649831016268 putative substrate binding site [chemical binding]; other site 649831016269 putative cosubstrate binding site; other site 649831016270 catalytic site [active] 649831016271 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 649831016272 alpha-gamma subunit interface [polypeptide binding]; other site 649831016273 beta-gamma subunit interface [polypeptide binding]; other site 649831016274 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 649831016275 gamma-beta subunit interface [polypeptide binding]; other site 649831016276 alpha-beta subunit interface [polypeptide binding]; other site 649831016277 urease subunit alpha; Reviewed; Region: ureC; PRK13206 649831016278 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 649831016279 subunit interactions [polypeptide binding]; other site 649831016280 active site 649831016281 flap region; other site 649831016282 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 649831016283 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 649831016284 AAA domain; Region: AAA_23; pfam13476 649831016285 UreD urease accessory protein; Region: UreD; cl00530 649831016286 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 649831016287 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 649831016288 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 649831016289 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 649831016290 DNA binding residues [nucleotide binding] 649831016291 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 649831016292 Catalytic domain of Protein Kinases; Region: PKc; cd00180 649831016293 active site 649831016294 ATP binding site [chemical binding]; other site 649831016295 substrate binding site [chemical binding]; other site 649831016296 activation loop (A-loop); other site 649831016297 Cellulose binding domain; Region: CBM_2; cl17741 649831016298 cyanophycin synthetase; Provisional; Region: PRK14016 649831016299 ATP-grasp domain; Region: ATP-grasp_4; cl17255 649831016300 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 649831016301 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 649831016302 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 649831016303 proposed catalytic triad [active] 649831016304 active site nucleophile [active] 649831016305 Transmembrane secretion effector; Region: MFS_3; pfam05977 649831016306 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831016307 Predicted transcriptional regulators [Transcription]; Region: COG1733 649831016308 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 649831016309 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 649831016310 CoenzymeA binding site [chemical binding]; other site 649831016311 subunit interaction site [polypeptide binding]; other site 649831016312 PHB binding site; other site 649831016313 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 649831016314 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 649831016315 dimer interface [polypeptide binding]; other site 649831016316 motif 1; other site 649831016317 active site 649831016318 motif 2; other site 649831016319 motif 3; other site 649831016320 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 649831016321 anticodon binding site; other site 649831016322 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 649831016323 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 649831016324 active site 649831016325 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 649831016326 active site 649831016327 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; cl17722 649831016328 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 649831016329 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 649831016330 Zn2+ binding site [ion binding]; other site 649831016331 Mg2+ binding site [ion binding]; other site 649831016332 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 649831016333 synthetase active site [active] 649831016334 NTP binding site [chemical binding]; other site 649831016335 metal binding site [ion binding]; metal-binding site 649831016336 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 649831016337 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 649831016338 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 649831016339 active site 649831016340 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 649831016341 Protein export membrane protein; Region: SecD_SecF; cl14618 649831016342 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 649831016343 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 649831016344 Preprotein translocase subunit; Region: YajC; pfam02699 649831016345 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 649831016346 thioester formation/cholesterol transfer; other site 649831016347 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 649831016348 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 649831016349 Walker B motif; other site 649831016350 arginine finger; other site 649831016351 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 649831016352 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 649831016353 RuvA N terminal domain; Region: RuvA_N; pfam01330 649831016354 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 649831016355 active site 649831016356 putative DNA-binding cleft [nucleotide binding]; other site 649831016357 dimer interface [polypeptide binding]; other site 649831016358 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 649831016359 hypothetical protein; Validated; Region: PRK00110 649831016360 imidazole glycerol phosphate synthase subunit hisH; Provisional; Region: hisH; CHL00188 649831016361 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 649831016362 predicted active site [active] 649831016363 catalytic triad [active] 649831016364 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 649831016365 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 649831016366 active site 649831016367 multimer interface [polypeptide binding]; other site 649831016368 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 649831016369 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 649831016370 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 649831016371 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 649831016372 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 649831016373 putative acyl-acceptor binding pocket; other site 649831016374 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 649831016375 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 649831016376 elongation factor G; Reviewed; Region: PRK12740 649831016377 G1 box; other site 649831016378 putative GEF interaction site [polypeptide binding]; other site 649831016379 GTP/Mg2+ binding site [chemical binding]; other site 649831016380 Switch I region; other site 649831016381 G2 box; other site 649831016382 G3 box; other site 649831016383 Switch II region; other site 649831016384 G4 box; other site 649831016385 G5 box; other site 649831016386 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 649831016387 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 649831016388 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 649831016389 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 649831016390 nucleotide binding site/active site [active] 649831016391 HIT family signature motif; other site 649831016392 catalytic residue [active] 649831016393 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 649831016394 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 649831016395 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 649831016396 DNA binding residues [nucleotide binding] 649831016397 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 649831016398 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 649831016399 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 649831016400 active site 649831016401 dimer interface [polypeptide binding]; other site 649831016402 motif 1; other site 649831016403 motif 2; other site 649831016404 motif 3; other site 649831016405 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 649831016406 anticodon binding site; other site 649831016407 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 649831016408 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 649831016409 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831016410 active site 649831016411 phosphorylation site [posttranslational modification] 649831016412 intermolecular recognition site; other site 649831016413 dimerization interface [polypeptide binding]; other site 649831016414 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 649831016415 DNA binding site [nucleotide binding] 649831016416 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 649831016417 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 649831016418 dimerization interface [polypeptide binding]; other site 649831016419 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 649831016420 dimer interface [polypeptide binding]; other site 649831016421 phosphorylation site [posttranslational modification] 649831016422 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831016423 ATP binding site [chemical binding]; other site 649831016424 Mg2+ binding site [ion binding]; other site 649831016425 G-X-G motif; other site 649831016426 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 649831016427 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cl15820 649831016428 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 649831016429 putative sugar binding sites [chemical binding]; other site 649831016430 Q-X-W motif; other site 649831016431 adenosine deaminase; Provisional; Region: PRK09358 649831016432 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 649831016433 active site 649831016434 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 649831016435 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649831016436 S-adenosylmethionine binding site [chemical binding]; other site 649831016437 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 649831016438 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 649831016439 active site 649831016440 catalytic tetrad [active] 649831016441 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 649831016442 DNA-binding site [nucleotide binding]; DNA binding site 649831016443 RNA-binding motif; other site 649831016444 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 649831016445 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 649831016446 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 649831016447 Predicted acetyltransferase [General function prediction only]; Region: COG2388 649831016448 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 649831016449 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 649831016450 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 649831016451 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 649831016452 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 649831016453 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 649831016454 ATP binding site [chemical binding]; other site 649831016455 putative Mg++ binding site [ion binding]; other site 649831016456 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 649831016457 nucleotide binding region [chemical binding]; other site 649831016458 ATP-binding site [chemical binding]; other site 649831016459 Protein of unknown function (DUF3553); Region: DUF3553; pfam12073 649831016460 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 649831016461 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 649831016462 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 649831016463 ligand binding site [chemical binding]; other site 649831016464 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 649831016465 Interdomain contacts; other site 649831016466 Cytokine receptor motif; other site 649831016467 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 649831016468 Interdomain contacts; other site 649831016469 Cytokine receptor motif; other site 649831016470 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 649831016471 Interdomain contacts; other site 649831016472 Cytokine receptor motif; other site 649831016473 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 649831016474 Interdomain contacts; other site 649831016475 Cytokine receptor motif; other site 649831016476 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 649831016477 Interdomain contacts; other site 649831016478 Cytokine receptor motif; other site 649831016479 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 649831016480 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 649831016481 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649831016482 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831016483 active site 649831016484 phosphorylation site [posttranslational modification] 649831016485 intermolecular recognition site; other site 649831016486 dimerization interface [polypeptide binding]; other site 649831016487 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649831016488 DNA binding residues [nucleotide binding] 649831016489 dimerization interface [polypeptide binding]; other site 649831016490 Histidine kinase; Region: HisKA_3; pfam07730 649831016491 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 649831016492 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831016493 ATP binding site [chemical binding]; other site 649831016494 Mg2+ binding site [ion binding]; other site 649831016495 G-X-G motif; other site 649831016496 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 649831016497 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 649831016498 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 649831016499 Walker A/P-loop; other site 649831016500 ATP binding site [chemical binding]; other site 649831016501 Q-loop/lid; other site 649831016502 ABC transporter signature motif; other site 649831016503 Walker B; other site 649831016504 D-loop; other site 649831016505 H-loop/switch region; other site 649831016506 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 649831016507 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 649831016508 putative ADP-binding pocket [chemical binding]; other site 649831016509 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 649831016510 hydrophobic ligand binding site; other site 649831016511 short chain dehydrogenase; Provisional; Region: PRK07109 649831016512 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 649831016513 putative NAD(P) binding site [chemical binding]; other site 649831016514 active site 649831016515 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 649831016516 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 649831016517 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 649831016518 putative hydrophobic ligand binding site [chemical binding]; other site 649831016519 Conserved TM helix; Region: TM_helix; pfam05552 649831016520 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 649831016521 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 649831016522 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 649831016523 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 649831016524 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 649831016525 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 649831016526 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 649831016527 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 649831016528 motif II; other site 649831016529 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 649831016530 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 649831016531 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 649831016532 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 649831016533 Protein of unknown function (DUF3072); Region: DUF3072; pfam11272 649831016534 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2739; cl17893 649831016535 Clp amino terminal domain; Region: Clp_N; pfam02861 649831016536 Clp amino terminal domain; Region: Clp_N; pfam02861 649831016537 Pirin-related protein [General function prediction only]; Region: COG1741 649831016538 Pirin; Region: Pirin; pfam02678 649831016539 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 649831016540 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 649831016541 MarR family; Region: MarR_2; pfam12802 649831016542 Domain of unknown function (DUF222); Region: DUF222; pfam02720 649831016543 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 649831016544 active site 649831016545 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 649831016546 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 649831016547 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 649831016548 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649831016549 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831016550 active site 649831016551 phosphorylation site [posttranslational modification] 649831016552 intermolecular recognition site; other site 649831016553 dimerization interface [polypeptide binding]; other site 649831016554 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649831016555 DNA binding residues [nucleotide binding] 649831016556 dimerization interface [polypeptide binding]; other site 649831016557 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 649831016558 Histidine kinase; Region: HisKA_3; pfam07730 649831016559 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 649831016560 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 649831016561 putative active site [active] 649831016562 catalytic site [active] 649831016563 Catalytic domain, repeat 2, of vertebrate phospholipases, PLD1 and PLD2, and similar proteins; Region: PLDc_vPLD1_2_like_2; cd09105 649831016564 putative active site [active] 649831016565 catalytic site [active] 649831016566 methyltransferase, ATP-grasp peptide maturase system; Region: methyltr_grsp; TIGR04188 649831016567 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 649831016568 Phosphotransferase enzyme family; Region: APH; pfam01636 649831016569 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 649831016570 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 649831016571 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 649831016572 allantoicase; Provisional; Region: PRK13257 649831016573 Allantoicase repeat; Region: Allantoicase; pfam03561 649831016574 Allantoicase repeat; Region: Allantoicase; pfam03561 649831016575 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 649831016576 active site 649831016577 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 649831016578 malate synthase A; Region: malate_syn_A; TIGR01344 649831016579 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 649831016580 active site 649831016581 Carbohydrate Binding Module 6 (CBM6); appended to glycoside hydrolase (GH) domains, including GH5 (cellulase); Region: CBM6_cellulase-like; cd04080 649831016582 Ca binding site [ion binding]; other site 649831016583 ligand binding site I [chemical binding]; other site 649831016584 homodimer interface [polypeptide binding]; other site 649831016585 ligand binding site II [chemical binding]; other site 649831016586 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 649831016587 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 649831016588 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 649831016589 active site 649831016590 putative substrate binding pocket [chemical binding]; other site 649831016591 urate oxidase; Region: urate_oxi; TIGR03383 649831016592 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 649831016593 active site 649831016594 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 649831016595 active site 649831016596 homotetramer interface [polypeptide binding]; other site 649831016597 putative OHCU decarboxylase; Provisional; Region: PRK13798 649831016598 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 649831016599 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 649831016600 ATP binding site [chemical binding]; other site 649831016601 putative Mg++ binding site [ion binding]; other site 649831016602 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 649831016603 nucleotide binding region [chemical binding]; other site 649831016604 ATP-binding site [chemical binding]; other site 649831016605 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 649831016606 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 649831016607 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 649831016608 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 649831016609 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831016610 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 649831016611 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 649831016612 metal binding site [ion binding]; metal-binding site 649831016613 active site 649831016614 I-site; other site 649831016615 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 649831016616 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 649831016617 active site 649831016618 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 649831016619 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 649831016620 substrate binding pocket [chemical binding]; other site 649831016621 membrane-bound complex binding site; other site 649831016622 hinge residues; other site 649831016623 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 649831016624 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 649831016625 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 649831016626 catalytic site [active] 649831016627 active site 649831016628 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 649831016629 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 649831016630 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 649831016631 active site 649831016632 catalytic site [active] 649831016633 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 649831016634 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 649831016635 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 649831016636 active site 649831016637 catalytic site [active] 649831016638 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 649831016639 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 649831016640 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 649831016641 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 649831016642 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 649831016643 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 649831016644 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 649831016645 EcsC protein family; Region: EcsC; pfam12787 649831016646 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 649831016647 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 649831016648 metal binding site [ion binding]; metal-binding site 649831016649 active site 649831016650 I-site; other site 649831016651 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 649831016652 PAC2 family; Region: PAC2; pfam09754 649831016653 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 649831016654 active site 649831016655 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 649831016656 GAF domain; Region: GAF_2; pfam13185 649831016657 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 649831016658 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 649831016659 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 649831016660 dimer interface [polypeptide binding]; other site 649831016661 putative CheW interface [polypeptide binding]; other site 649831016662 S-formylglutathione hydrolase; Region: PLN02442 649831016663 Predicted esterase [General function prediction only]; Region: COG0627 649831016664 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649831016665 S-adenosylmethionine binding site [chemical binding]; other site 649831016666 GAF domain; Region: GAF; pfam01590 649831016667 PAS domain; Region: PAS; smart00091 649831016668 PAS fold; Region: PAS_4; pfam08448 649831016669 GAF domain; Region: GAF_3; pfam13492 649831016670 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 649831016671 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 649831016672 dimer interface [polypeptide binding]; other site 649831016673 phosphorylation site [posttranslational modification] 649831016674 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831016675 ATP binding site [chemical binding]; other site 649831016676 Mg2+ binding site [ion binding]; other site 649831016677 G-X-G motif; other site 649831016678 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649831016679 S-adenosylmethionine binding site [chemical binding]; other site 649831016680 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 649831016681 Integrase core domain; Region: rve; pfam00665 649831016682 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831016683 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 649831016684 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 649831016685 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 649831016686 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 649831016687 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 649831016688 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649831016689 Walker A/P-loop; other site 649831016690 ATP binding site [chemical binding]; other site 649831016691 Q-loop/lid; other site 649831016692 ABC transporter signature motif; other site 649831016693 Walker B; other site 649831016694 D-loop; other site 649831016695 H-loop/switch region; other site 649831016696 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 649831016697 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 649831016698 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649831016699 Walker A/P-loop; other site 649831016700 ATP binding site [chemical binding]; other site 649831016701 Q-loop/lid; other site 649831016702 ABC transporter signature motif; other site 649831016703 Walker B; other site 649831016704 D-loop; other site 649831016705 H-loop/switch region; other site 649831016706 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 649831016707 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 649831016708 TAP-like protein; Region: Abhydrolase_4; pfam08386 649831016709 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 649831016710 active site 649831016711 Zn binding site [ion binding]; other site 649831016712 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 649831016713 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u2; cd11478 649831016714 Na binding site [ion binding]; other site 649831016715 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 649831016716 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 649831016717 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 649831016718 Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566 649831016719 This novel putative carbohydrate binding module (NPCBM) domain is found at the N-terminus of glycosyl hydrolase family 98 proteins; Region: NPCBM; smart00776 649831016720 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 649831016721 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 649831016722 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 649831016723 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 649831016724 motif II; other site 649831016725 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 649831016726 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 649831016727 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 649831016728 Putative Catalytic site; other site 649831016729 DXD motif; other site 649831016730 glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554 649831016731 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 649831016732 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 649831016733 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 649831016734 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 649831016735 Glycosyl hydrolase catalytic core; Region: Glyco_hydro_cc; pfam11790 649831016736 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 649831016737 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831016738 ATP binding site [chemical binding]; other site 649831016739 Mg2+ binding site [ion binding]; other site 649831016740 G-X-G motif; other site 649831016741 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 649831016742 MarR family; Region: MarR_2; pfam12802 649831016743 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 649831016744 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 649831016745 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 649831016746 Lsr2; Region: Lsr2; pfam11774 649831016747 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 649831016748 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 649831016749 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 649831016750 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 649831016751 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 649831016752 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 649831016753 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 649831016754 DNA binding residues [nucleotide binding] 649831016755 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 649831016756 Part of AAA domain; Region: AAA_19; pfam13245 649831016757 Family description; Region: UvrD_C_2; pfam13538 649831016758 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 649831016759 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 649831016760 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 649831016761 DNA binding residues [nucleotide binding] 649831016762 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 649831016763 DEAD-like helicases superfamily; Region: DEXDc; smart00487 649831016764 ATP binding site [chemical binding]; other site 649831016765 Mg++ binding site [ion binding]; other site 649831016766 motif III; other site 649831016767 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 649831016768 nucleotide binding region [chemical binding]; other site 649831016769 ATP-binding site [chemical binding]; other site 649831016770 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 649831016771 Uncharacterized conserved protein [Function unknown]; Region: COG4850 649831016772 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 649831016773 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 649831016774 Transcriptional regulators [Transcription]; Region: PurR; COG1609 649831016775 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 649831016776 DNA binding site [nucleotide binding] 649831016777 domain linker motif; other site 649831016778 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 649831016779 dimerization interface [polypeptide binding]; other site 649831016780 ligand binding site [chemical binding]; other site 649831016781 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 649831016782 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 649831016783 substrate binding site [chemical binding]; other site 649831016784 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 649831016785 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 649831016786 Walker A/P-loop; other site 649831016787 ATP binding site [chemical binding]; other site 649831016788 Q-loop/lid; other site 649831016789 ABC transporter signature motif; other site 649831016790 Walker B; other site 649831016791 D-loop; other site 649831016792 H-loop/switch region; other site 649831016793 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 649831016794 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 649831016795 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649831016796 dimer interface [polypeptide binding]; other site 649831016797 conserved gate region; other site 649831016798 putative PBP binding loops; other site 649831016799 ABC-ATPase subunit interface; other site 649831016800 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 649831016801 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 649831016802 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649831016803 putative PBP binding loops; other site 649831016804 dimer interface [polypeptide binding]; other site 649831016805 ABC-ATPase subunit interface; other site 649831016806 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 649831016807 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 649831016808 Walker A/P-loop; other site 649831016809 ATP binding site [chemical binding]; other site 649831016810 Q-loop/lid; other site 649831016811 ABC transporter signature motif; other site 649831016812 Walker B; other site 649831016813 D-loop; other site 649831016814 H-loop/switch region; other site 649831016815 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 649831016816 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 649831016817 beta-galactosidase; Region: BGL; TIGR03356 649831016818 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 649831016819 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 649831016820 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 649831016821 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 649831016822 putative sugar binding sites [chemical binding]; other site 649831016823 Q-X-W motif; other site 649831016824 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 649831016825 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 649831016826 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 649831016827 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 649831016828 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 649831016829 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 649831016830 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831016831 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 649831016832 classical (c) SDRs; Region: SDR_c; cd05233 649831016833 NAD(P) binding site [chemical binding]; other site 649831016834 active site 649831016835 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 649831016836 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 649831016837 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 649831016838 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 649831016839 DNA binding residues [nucleotide binding] 649831016840 amidase; Provisional; Region: PRK06170 649831016841 Amidase; Region: Amidase; cl11426 649831016842 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 649831016843 Interdomain contacts; other site 649831016844 Cytokine receptor motif; other site 649831016845 Cellulose binding domain; Region: CBM_2; pfam00553 649831016846 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 649831016847 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 649831016848 substrate binding pocket [chemical binding]; other site 649831016849 membrane-bound complex binding site; other site 649831016850 hinge residues; other site 649831016851 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 649831016852 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 649831016853 CAP-like domain; other site 649831016854 active site 649831016855 primary dimer interface [polypeptide binding]; other site 649831016856 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 649831016857 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 649831016858 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 649831016859 ATP binding site [chemical binding]; other site 649831016860 Mg2+ binding site [ion binding]; other site 649831016861 G-X-G motif; other site 649831016862 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 649831016863 anchoring element; other site 649831016864 dimer interface [polypeptide binding]; other site 649831016865 ATP binding site [chemical binding]; other site 649831016866 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 649831016867 active site 649831016868 metal binding site [ion binding]; metal-binding site 649831016869 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 649831016870 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 649831016871 Catalytic domain of Protein Kinases; Region: PKc; cd00180 649831016872 active site 649831016873 ATP binding site [chemical binding]; other site 649831016874 substrate binding site [chemical binding]; other site 649831016875 activation loop (A-loop); other site 649831016876 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 649831016877 Walker A motif; other site 649831016878 ATP binding site [chemical binding]; other site 649831016879 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 649831016880 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 649831016881 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 649831016882 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 649831016883 metal binding site [ion binding]; metal-binding site 649831016884 active site 649831016885 I-site; other site 649831016886 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 649831016887 cyclase homology domain; Region: CHD; cd07302 649831016888 nucleotidyl binding site; other site 649831016889 metal binding site [ion binding]; metal-binding site 649831016890 dimer interface [polypeptide binding]; other site 649831016891 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649831016892 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649831016893 dimerization interface [polypeptide binding]; other site 649831016894 DNA binding residues [nucleotide binding] 649831016895 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 649831016896 dimer interface [polypeptide binding]; other site 649831016897 phosphorylation site [posttranslational modification] 649831016898 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 649831016899 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 649831016900 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831016901 active site 649831016902 phosphorylation site [posttranslational modification] 649831016903 intermolecular recognition site; other site 649831016904 dimerization interface [polypeptide binding]; other site 649831016905 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 649831016906 DNA binding site [nucleotide binding] 649831016907 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 649831016908 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 649831016909 active site 649831016910 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 649831016911 sugar binding site [chemical binding]; other site 649831016912 Streptomyces laminarinase-like, member of glycosyl hydrolase family 16; Region: GH16_Strep_laminarinase_like; cd02182 649831016913 active site 649831016914 catalytic residues [active] 649831016915 Glucanosyltransferase; Region: Glyco_hydro_72; pfam03198 649831016916 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 649831016917 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 649831016918 sugar binding site [chemical binding]; other site 649831016919 Domain of unknown function (DUF305); Region: DUF305; cl17794 649831016920 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 649831016921 sugar binding site [chemical binding]; other site 649831016922 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 649831016923 Hemerythrin-like domain; Region: Hr-like; cd12108 649831016924 Fe binding site [ion binding]; other site 649831016925 Transcriptional regulators [Transcription]; Region: PurR; COG1609 649831016926 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 649831016927 DNA binding site [nucleotide binding] 649831016928 domain linker motif; other site 649831016929 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 649831016930 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 649831016931 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 649831016932 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 649831016933 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 649831016934 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 649831016935 putative dimer interface [polypeptide binding]; other site 649831016936 N-terminal domain interface [polypeptide binding]; other site 649831016937 putative substrate binding pocket (H-site) [chemical binding]; other site 649831016938 SWIM zinc finger; Region: SWIM; pfam04434 649831016939 MoxR-like ATPases [General function prediction only]; Region: COG0714 649831016940 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 649831016941 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 649831016942 metal ion-dependent adhesion site (MIDAS); other site 649831016943 Amidohydrolase; Region: Amidohydro_2; pfam04909 649831016944 active site 649831016945 Transcriptional regulator [Transcription]; Region: LysR; COG0583 649831016946 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 649831016947 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 649831016948 substrate binding pocket [chemical binding]; other site 649831016949 dimerization interface [polypeptide binding]; other site 649831016950 Phosphotransferase enzyme family; Region: APH; pfam01636 649831016951 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 649831016952 active site 649831016953 ATP binding site [chemical binding]; other site 649831016954 substrate binding site [chemical binding]; other site 649831016955 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 649831016956 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 649831016957 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 649831016958 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 649831016959 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 649831016960 active site 649831016961 ATP binding site [chemical binding]; other site 649831016962 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 649831016963 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 649831016964 nudix motif; other site 649831016965 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 649831016966 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 649831016967 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 649831016968 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 649831016969 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102 649831016970 Patatin-like phospholipase; Region: Patatin; pfam01734 649831016971 nucleophile elbow; other site 649831016972 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 649831016973 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 649831016974 Moco binding site; other site 649831016975 metal coordination site [ion binding]; other site 649831016976 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 649831016977 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_3; cd06217 649831016978 FAD binding pocket [chemical binding]; other site 649831016979 FAD binding motif [chemical binding]; other site 649831016980 phosphate binding motif [ion binding]; other site 649831016981 beta-alpha-beta structure motif; other site 649831016982 NAD binding pocket [chemical binding]; other site 649831016983 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 649831016984 active site 649831016985 catalytic triad [active] 649831016986 oxyanion hole [active] 649831016987 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 649831016988 aspartate racemase; Region: asp_race; TIGR00035 649831016989 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 649831016990 DmpA/OAT superfamily; composed of L-aminopeptidase D-amidase/D-esterase (DmpA), ornithine acetyltransferase (OAT) and similar proteins. DmpA is an aminopeptidase that releases N-terminal D and L amino acids from peptide substrates. This group represents...; Region: DmpA_OAT; cl00603 649831016991 cleavage site 649831016992 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 649831016993 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831016994 active site 649831016995 phosphorylation site [posttranslational modification] 649831016996 intermolecular recognition site; other site 649831016997 dimerization interface [polypeptide binding]; other site 649831016998 HTH domain; Region: HTH_11; pfam08279 649831016999 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 649831017000 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831017001 Mg2+ binding site [ion binding]; other site 649831017002 G-X-G motif; other site 649831017003 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 649831017004 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 649831017005 Walker A/P-loop; other site 649831017006 ATP binding site [chemical binding]; other site 649831017007 Q-loop/lid; other site 649831017008 ABC transporter signature motif; other site 649831017009 Walker B; other site 649831017010 D-loop; other site 649831017011 H-loop/switch region; other site 649831017012 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 649831017013 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 649831017014 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 649831017015 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 649831017016 substrate binding pocket [chemical binding]; other site 649831017017 membrane-bound complex binding site; other site 649831017018 elongation factor Tu; Reviewed; Region: PRK12736 649831017019 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 649831017020 G1 box; other site 649831017021 GEF interaction site [polypeptide binding]; other site 649831017022 GTP/Mg2+ binding site [chemical binding]; other site 649831017023 Switch I region; other site 649831017024 G2 box; other site 649831017025 G3 box; other site 649831017026 Switch II region; other site 649831017027 G4 box; other site 649831017028 G5 box; other site 649831017029 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 649831017030 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 649831017031 Antibiotic Binding Site [chemical binding]; other site 649831017032 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 649831017033 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 649831017034 Catalytic domain of Protein Kinases; Region: PKc; cd00180 649831017035 active site 649831017036 ATP binding site [chemical binding]; other site 649831017037 substrate binding site [chemical binding]; other site 649831017038 activation loop (A-loop); other site 649831017039 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 649831017040 PAS domain; Region: PAS_9; pfam13426 649831017041 putative active site [active] 649831017042 heme pocket [chemical binding]; other site 649831017043 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 649831017044 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 649831017045 dimer interface [polypeptide binding]; other site 649831017046 phosphorylation site [posttranslational modification] 649831017047 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831017048 ATP binding site [chemical binding]; other site 649831017049 Mg2+ binding site [ion binding]; other site 649831017050 G-X-G motif; other site 649831017051 Response regulator receiver domain; Region: Response_reg; pfam00072 649831017052 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831017053 active site 649831017054 phosphorylation site [posttranslational modification] 649831017055 intermolecular recognition site; other site 649831017056 dimerization interface [polypeptide binding]; other site 649831017057 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 649831017058 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 649831017059 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 649831017060 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 649831017061 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 649831017062 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 649831017063 active site 649831017064 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 649831017065 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649831017066 Walker A/P-loop; other site 649831017067 ATP binding site [chemical binding]; other site 649831017068 Q-loop/lid; other site 649831017069 ABC transporter signature motif; other site 649831017070 Walker B; other site 649831017071 D-loop; other site 649831017072 H-loop/switch region; other site 649831017073 OsmC-like protein; Region: OsmC; pfam02566 649831017074 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649831017075 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 649831017076 Walker A/P-loop; other site 649831017077 ATP binding site [chemical binding]; other site 649831017078 Q-loop/lid; other site 649831017079 ABC transporter signature motif; other site 649831017080 Walker B; other site 649831017081 D-loop; other site 649831017082 H-loop/switch region; other site 649831017083 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 649831017084 FtsX-like permease family; Region: FtsX; pfam02687 649831017085 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 649831017086 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 649831017087 oligomer interface [polypeptide binding]; other site 649831017088 metal binding site [ion binding]; metal-binding site 649831017089 metal binding site [ion binding]; metal-binding site 649831017090 putative Cl binding site [ion binding]; other site 649831017091 aspartate ring; other site 649831017092 basic sphincter; other site 649831017093 hydrophobic gate; other site 649831017094 periplasmic entrance; other site 649831017095 Alginate lyase; Region: Alginate_lyase2; pfam08787 649831017096 Polysaccharide lyase; Region: Polysacc_lyase; pfam14099 649831017097 short chain dehydrogenase; Provisional; Region: PRK08263 649831017098 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 649831017099 NADP binding site [chemical binding]; other site 649831017100 active site 649831017101 steroid binding site; other site 649831017102 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 649831017103 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 649831017104 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 649831017105 DNA binding residues [nucleotide binding] 649831017106 Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224 649831017107 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 649831017108 Sulfatase; Region: Sulfatase; pfam00884 649831017109 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 649831017110 dimer interface [polypeptide binding]; other site 649831017111 catalytic triad [active] 649831017112 PRC-barrel domain; Region: PRC; pfam05239 649831017113 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 649831017114 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 649831017115 dimerization interface [polypeptide binding]; other site 649831017116 putative DNA binding site [nucleotide binding]; other site 649831017117 putative Zn2+ binding site [ion binding]; other site 649831017118 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 649831017119 putative hydrophobic ligand binding site [chemical binding]; other site 649831017120 TIGR03086 family protein; Region: TIGR03086 649831017121 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 649831017122 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 649831017123 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 649831017124 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 649831017125 glucuronate isomerase; Reviewed; Region: PRK02925 649831017126 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 649831017127 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 649831017128 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 649831017129 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649831017130 dimer interface [polypeptide binding]; other site 649831017131 conserved gate region; other site 649831017132 putative PBP binding loops; other site 649831017133 ABC-ATPase subunit interface; other site 649831017134 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 649831017135 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649831017136 dimer interface [polypeptide binding]; other site 649831017137 conserved gate region; other site 649831017138 putative PBP binding loops; other site 649831017139 ABC-ATPase subunit interface; other site 649831017140 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 649831017141 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 649831017142 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 649831017143 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 649831017144 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 649831017145 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 649831017146 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 649831017147 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 649831017148 Transcriptional regulators [Transcription]; Region: PurR; COG1609 649831017149 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 649831017150 DNA binding site [nucleotide binding] 649831017151 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 649831017152 ligand binding site [chemical binding]; other site 649831017153 dimerization interface [polypeptide binding]; other site 649831017154 TIGR00268 family protein; Region: TIGR00268 649831017155 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 649831017156 Ligand Binding Site [chemical binding]; other site 649831017157 PT repeat; Region: PT; pfam04886 649831017158 AIR carboxylase; Region: AIRC; smart01001 649831017159 hypothetical protein; Provisional; Region: PRK04194 649831017160 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 649831017161 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 649831017162 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 649831017163 Histidine kinase; Region: HisKA_3; pfam07730 649831017164 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831017165 ATP binding site [chemical binding]; other site 649831017166 Mg2+ binding site [ion binding]; other site 649831017167 G-X-G motif; other site 649831017168 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 649831017169 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831017170 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 649831017171 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 649831017172 putative NAD(P) binding site [chemical binding]; other site 649831017173 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 649831017174 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 649831017175 Helix-turn-helix domain; Region: HTH_18; pfam12833 649831017176 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 649831017177 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 649831017178 Putative transmembrane protein (PGPGW); Region: PGPGW; cl09870 649831017179 Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686 649831017180 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 649831017181 Helix-turn-helix domain; Region: HTH_18; pfam12833 649831017182 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 649831017183 Rrf2 family protein; Region: rrf2_super; TIGR00738 649831017184 Transcriptional regulator; Region: Rrf2; pfam02082 649831017185 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 649831017186 Interdomain contacts; other site 649831017187 Cytokine receptor motif; other site 649831017188 Caspase domain; Region: Peptidase_C14; pfam00656 649831017189 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 649831017190 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 649831017191 metal binding site [ion binding]; metal-binding site 649831017192 active site 649831017193 I-site; other site 649831017194 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 649831017195 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 649831017196 putative catalytic site [active] 649831017197 putative metal binding site [ion binding]; other site 649831017198 putative phosphate binding site [ion binding]; other site 649831017199 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 649831017200 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 649831017201 active site 649831017202 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 649831017203 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 649831017204 active site 649831017205 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 649831017206 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 649831017207 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 649831017208 Domain of unknown function (DUF1990); Region: DUF1990; pfam09348 649831017209 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 649831017210 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 649831017211 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 649831017212 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 649831017213 Alpha-lytic protease prodomain; Region: Pro_Al_protease; pfam02983 649831017214 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 649831017215 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 649831017216 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831017217 Major Facilitator Superfamily; Region: MFS_1; pfam07690 649831017218 putative substrate translocation pore; other site 649831017219 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831017220 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 649831017221 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 649831017222 DNA binding site [nucleotide binding] 649831017223 hypothetical protein; Provisional; Region: PRK06771 649831017224 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 649831017225 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 649831017226 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 649831017227 D-cysteine desulfhydrase; Validated; Region: PRK03910 649831017228 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 649831017229 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 649831017230 catalytic residue [active] 649831017231 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 649831017232 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 649831017233 motif II; other site 649831017234 Domain of unknown function (DUF389); Region: DUF389; cl00781 649831017235 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 649831017236 metal-binding site 649831017237 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 649831017238 conserved cys residue [active] 649831017239 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 649831017240 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 649831017241 Isochorismatase family; Region: Isochorismatase; pfam00857 649831017242 catalytic triad [active] 649831017243 conserved cis-peptide bond; other site 649831017244 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 649831017245 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831017246 NAD(P) binding site [chemical binding]; other site 649831017247 active site 649831017248 TAP-like protein; Region: Abhydrolase_4; pfam08386 649831017249 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 649831017250 active site 649831017251 intersubunit interface [polypeptide binding]; other site 649831017252 catalytic residue [active] 649831017253 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 649831017254 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 649831017255 substrate binding site [chemical binding]; other site 649831017256 ATP binding site [chemical binding]; other site 649831017257 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 649831017258 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 649831017259 putative NAD(P) binding site [chemical binding]; other site 649831017260 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 649831017261 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 649831017262 metal binding site [ion binding]; metal-binding site 649831017263 active site 649831017264 I-site; other site 649831017265 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 649831017266 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 649831017267 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 649831017268 Ca binding site [ion binding]; other site 649831017269 active site 649831017270 catalytic site [active] 649831017271 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 649831017272 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 649831017273 putative ADP-binding pocket [chemical binding]; other site 649831017274 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 649831017275 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 649831017276 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 649831017277 active site 649831017278 hypothetical protein; Provisional; Region: PRK08317 649831017279 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649831017280 S-adenosylmethionine binding site [chemical binding]; other site 649831017281 putative oxidoreductase; Provisional; Region: PRK11579 649831017282 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 649831017283 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 649831017284 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831017285 NmrA-like family; Region: NmrA; pfam05368 649831017286 NAD(P) binding site [chemical binding]; other site 649831017287 active site 649831017288 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 649831017289 active site 649831017290 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 649831017291 kynureninase; Region: kynureninase; TIGR01814 649831017292 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 649831017293 catalytic residue [active] 649831017294 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012 649831017295 SEC-C motif; Region: SEC-C; pfam02810 649831017296 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 649831017297 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 649831017298 DNA binding residues [nucleotide binding] 649831017299 putative dimer interface [polypeptide binding]; other site 649831017300 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 649831017301 dimer interface [polypeptide binding]; other site 649831017302 putative CheW interface [polypeptide binding]; other site 649831017303 Transcriptional regulators [Transcription]; Region: PurR; COG1609 649831017304 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 649831017305 DNA binding site [nucleotide binding] 649831017306 domain linker motif; other site 649831017307 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_10; cd06292 649831017308 putative dimerization interface [polypeptide binding]; other site 649831017309 putative ligand binding site [chemical binding]; other site 649831017310 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 649831017311 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 649831017312 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 649831017313 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649831017314 dimer interface [polypeptide binding]; other site 649831017315 conserved gate region; other site 649831017316 putative PBP binding loops; other site 649831017317 ABC-ATPase subunit interface; other site 649831017318 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 649831017319 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 649831017320 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 649831017321 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 649831017322 active site 649831017323 catalytic site [active] 649831017324 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 649831017325 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 649831017326 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 649831017327 Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231 649831017328 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 649831017329 sugar binding site [chemical binding]; other site 649831017330 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 649831017331 Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231 649831017332 sugar binding site [chemical binding]; other site 649831017333 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 649831017334 sugar binding site [chemical binding]; other site 649831017335 CARDB; Region: CARDB; pfam07705 649831017336 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 649831017337 putative metal binding site [ion binding]; other site 649831017338 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 649831017339 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 649831017340 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 649831017341 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 649831017342 DNA binding residues [nucleotide binding] 649831017343 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 649831017344 Sulfate transporter family; Region: Sulfate_transp; pfam00916 649831017345 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 649831017346 active site clefts [active] 649831017347 zinc binding site [ion binding]; other site 649831017348 dimer interface [polypeptide binding]; other site 649831017349 pyruvate phosphate dikinase; Provisional; Region: PRK09279 649831017350 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 649831017351 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 649831017352 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 649831017353 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 649831017354 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 649831017355 active site 649831017356 dimer interface [polypeptide binding]; other site 649831017357 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 649831017358 Ligand Binding Site [chemical binding]; other site 649831017359 Molecular Tunnel; other site 649831017360 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 649831017361 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 649831017362 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 649831017363 D-galactonate transporter; Region: 2A0114; TIGR00893 649831017364 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831017365 putative substrate translocation pore; other site 649831017366 Protein of unknown function (DUF664); Region: DUF664; pfam04978 649831017367 DinB superfamily; Region: DinB_2; pfam12867 649831017368 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 649831017369 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 649831017370 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 649831017371 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 649831017372 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 649831017373 ligand binding site [chemical binding]; other site 649831017374 flexible hinge region; other site 649831017375 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831017376 ATP binding site [chemical binding]; other site 649831017377 Mg2+ binding site [ion binding]; other site 649831017378 G-X-G motif; other site 649831017379 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 649831017380 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831017381 active site 649831017382 phosphorylation site [posttranslational modification] 649831017383 intermolecular recognition site; other site 649831017384 dimerization interface [polypeptide binding]; other site 649831017385 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 649831017386 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 649831017387 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 649831017388 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 649831017389 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 649831017390 ATP-NAD kinase; Region: NAD_kinase; pfam01513 649831017391 Predicted acetyltransferase [General function prediction only]; Region: COG2388 649831017392 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 649831017393 Ricin-type beta-trefoil; Region: RICIN; smart00458 649831017394 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 649831017395 putative sugar binding sites [chemical binding]; other site 649831017396 Q-X-W motif; other site 649831017397 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831017398 putative substrate translocation pore; other site 649831017399 Protease prsW family; Region: PrsW-protease; pfam13367 649831017400 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 649831017401 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 649831017402 FAD binding pocket [chemical binding]; other site 649831017403 FAD binding motif [chemical binding]; other site 649831017404 phosphate binding motif [ion binding]; other site 649831017405 NAD binding pocket [chemical binding]; other site 649831017406 Phosphotransferase enzyme family; Region: APH; pfam01636 649831017407 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 649831017408 active site 649831017409 substrate binding site [chemical binding]; other site 649831017410 ATP binding site [chemical binding]; other site 649831017411 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 649831017412 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 649831017413 DNA binding residues [nucleotide binding] 649831017414 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 649831017415 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 649831017416 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 649831017417 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 649831017418 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649831017419 putative PBP binding loops; other site 649831017420 ABC-ATPase subunit interface; other site 649831017421 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 649831017422 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649831017423 Walker A/P-loop; other site 649831017424 ATP binding site [chemical binding]; other site 649831017425 Q-loop/lid; other site 649831017426 ABC transporter signature motif; other site 649831017427 Walker B; other site 649831017428 D-loop; other site 649831017429 H-loop/switch region; other site 649831017430 TOBE domain; Region: TOBE; cl01440 649831017431 Protein of unknown function (DUF1684); Region: DUF1684; pfam07920 649831017432 YGGT family; Region: YGGT; pfam02325 649831017433 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 649831017434 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 649831017435 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 649831017436 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 649831017437 Walker A/P-loop; other site 649831017438 ATP binding site [chemical binding]; other site 649831017439 Q-loop/lid; other site 649831017440 ABC transporter signature motif; other site 649831017441 Walker B; other site 649831017442 D-loop; other site 649831017443 H-loop/switch region; other site 649831017444 Predicted transcriptional regulators [Transcription]; Region: COG1695 649831017445 Transcriptional regulator PadR-like family; Region: PadR; cl17335 649831017446 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 649831017447 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831017448 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 649831017449 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 649831017450 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649831017451 Walker A/P-loop; other site 649831017452 ATP binding site [chemical binding]; other site 649831017453 Q-loop/lid; other site 649831017454 ABC transporter signature motif; other site 649831017455 Walker B; other site 649831017456 D-loop; other site 649831017457 H-loop/switch region; other site 649831017458 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 649831017459 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 649831017460 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 649831017461 Walker A/P-loop; other site 649831017462 ATP binding site [chemical binding]; other site 649831017463 Q-loop/lid; other site 649831017464 ABC transporter signature motif; other site 649831017465 Walker B; other site 649831017466 D-loop; other site 649831017467 H-loop/switch region; other site 649831017468 Calx-beta domain; Region: Calx-beta; cl02522 649831017469 Calx-beta domain; Region: Calx-beta; pfam03160 649831017470 TfoX N-terminal domain; Region: TfoX_N; cl17592 649831017471 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 649831017472 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 649831017473 dimer interface [polypeptide binding]; other site 649831017474 active site 649831017475 Methyltransferase domain; Region: Methyltransf_23; pfam13489 649831017476 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649831017477 S-adenosylmethionine binding site [chemical binding]; other site 649831017478 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 649831017479 active site 649831017480 catalytic residues [active] 649831017481 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 649831017482 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 649831017483 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 649831017484 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 649831017485 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 649831017486 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 649831017487 active site 649831017488 Chain length determinant protein; Region: Wzz; cl15801 649831017489 Oligosaccharide biosynthesis protein Alg14 like; Region: Alg14; pfam08660 649831017490 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 649831017491 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 649831017492 Bacterial sugar transferase; Region: Bac_transf; pfam02397 649831017493 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 649831017494 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 649831017495 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 649831017496 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 649831017497 Walker A/P-loop; other site 649831017498 ATP binding site [chemical binding]; other site 649831017499 Q-loop/lid; other site 649831017500 ABC transporter signature motif; other site 649831017501 Walker B; other site 649831017502 D-loop; other site 649831017503 H-loop/switch region; other site 649831017504 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 649831017505 ABC-2 type transporter; Region: ABC2_membrane; cl17235 649831017506 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 649831017507 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 649831017508 Walker A/P-loop; other site 649831017509 ATP binding site [chemical binding]; other site 649831017510 Q-loop/lid; other site 649831017511 ABC transporter signature motif; other site 649831017512 Walker B; other site 649831017513 D-loop; other site 649831017514 H-loop/switch region; other site 649831017515 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 649831017516 active site 649831017517 RNA/DNA hybrid binding site [nucleotide binding]; other site 649831017518 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 649831017519 active site 649831017520 catalytic site [active] 649831017521 substrate binding site [chemical binding]; other site 649831017522 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 649831017523 putative DNA binding site [nucleotide binding]; other site 649831017524 putative Zn2+ binding site [ion binding]; other site 649831017525 H+ Antiporter protein; Region: 2A0121; TIGR00900 649831017526 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831017527 putative substrate translocation pore; other site 649831017528 Transcriptional regulators [Transcription]; Region: PurR; COG1609 649831017529 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 649831017530 DNA binding site [nucleotide binding] 649831017531 domain linker motif; other site 649831017532 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 649831017533 dimerization interface [polypeptide binding]; other site 649831017534 ligand binding site [chemical binding]; other site 649831017535 Arginase-like amidino hydrolase family; Region: Arginase-like_1; cd09999 649831017536 active site 649831017537 Mn binding site [ion binding]; other site 649831017538 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 649831017539 Histidine kinase; Region: HisKA_3; pfam07730 649831017540 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 649831017541 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649831017542 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831017543 active site 649831017544 phosphorylation site [posttranslational modification] 649831017545 intermolecular recognition site; other site 649831017546 dimerization interface [polypeptide binding]; other site 649831017547 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649831017548 DNA binding residues [nucleotide binding] 649831017549 dimerization interface [polypeptide binding]; other site 649831017550 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 649831017551 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 649831017552 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 649831017553 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 649831017554 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 649831017555 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 649831017556 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649831017557 dimer interface [polypeptide binding]; other site 649831017558 conserved gate region; other site 649831017559 putative PBP binding loops; other site 649831017560 ABC-ATPase subunit interface; other site 649831017561 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 649831017562 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649831017563 dimer interface [polypeptide binding]; other site 649831017564 conserved gate region; other site 649831017565 putative PBP binding loops; other site 649831017566 ABC-ATPase subunit interface; other site 649831017567 Transcriptional regulators [Transcription]; Region: PurR; COG1609 649831017568 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 649831017569 DNA binding site [nucleotide binding] 649831017570 domain linker motif; other site 649831017571 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 649831017572 putative dimerization interface [polypeptide binding]; other site 649831017573 putative ligand binding site [chemical binding]; other site 649831017574 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; pfam07745 649831017575 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 649831017576 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 649831017577 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 649831017578 DNA binding residues [nucleotide binding] 649831017579 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 649831017580 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 649831017581 PAS domain S-box; Region: sensory_box; TIGR00229 649831017582 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 649831017583 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 649831017584 metal binding site [ion binding]; metal-binding site 649831017585 active site 649831017586 I-site; other site 649831017587 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 649831017588 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 649831017589 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 649831017590 dimer interface [polypeptide binding]; other site 649831017591 active site 649831017592 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 649831017593 catalytic residues [active] 649831017594 substrate binding site [chemical binding]; other site 649831017595 2-acyl-glycerophospho-ethanolamine acyltransferase; Validated; Region: PRK08633 649831017596 Rdx family; Region: Rdx; cl01407 649831017597 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 649831017598 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 649831017599 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 649831017600 sugar binding site [chemical binding]; other site 649831017601 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 649831017602 sugar binding site [chemical binding]; other site 649831017603 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 649831017604 active site 649831017605 catalytic residues [active] 649831017606 Transcriptional regulators [Transcription]; Region: PurR; COG1609 649831017607 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 649831017608 DNA binding site [nucleotide binding] 649831017609 domain linker motif; other site 649831017610 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 649831017611 putative dimerization interface [polypeptide binding]; other site 649831017612 putative ligand binding site [chemical binding]; other site 649831017613 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 649831017614 NADH(P)-binding; Region: NAD_binding_10; pfam13460 649831017615 NAD(P) binding site [chemical binding]; other site 649831017616 putative active site [active] 649831017617 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 649831017618 Tetratricopeptide repeat; Region: TPR_12; pfam13424 649831017619 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 649831017620 Coenzyme A binding pocket [chemical binding]; other site 649831017621 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 649831017622 Coenzyme A binding pocket [chemical binding]; other site 649831017623 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649831017624 Walker A/P-loop; other site 649831017625 ATP binding site [chemical binding]; other site 649831017626 Q-loop/lid; other site 649831017627 ABC transporter signature motif; other site 649831017628 glycoside hydrolase family 64: laminaripentaose-producing, beta-1,3-glucanase (LPHase)-like; Region: GH64-LPHase-like; cd09216 649831017629 substrate binding pocket [chemical binding]; other site 649831017630 catalytic residues [active] 649831017631 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 649831017632 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 649831017633 putative dimer interface [polypeptide binding]; other site 649831017634 Cupin superfamily (DUF985); Region: Cupin_5; cl01418 649831017635 DNA polymerase IV; Validated; Region: PRK03858 649831017636 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 649831017637 active site 649831017638 DNA binding site [nucleotide binding] 649831017639 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 649831017640 active site 649831017641 SAM binding site [chemical binding]; other site 649831017642 homodimer interface [polypeptide binding]; other site 649831017643 Nucleotidyltransferase domain; Region: NTP_transf_2; pfam01909 649831017644 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 649831017645 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 649831017646 non-specific DNA binding site [nucleotide binding]; other site 649831017647 salt bridge; other site 649831017648 sequence-specific DNA binding site [nucleotide binding]; other site 649831017649 Cupin domain; Region: Cupin_2; pfam07883 649831017650 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 649831017651 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 649831017652 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 649831017653 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 649831017654 precorrin-3B synthase; Region: CobG; TIGR02435 649831017655 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 649831017656 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 649831017657 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 649831017658 Precorrin-8X methylmutase; Region: CbiC; pfam02570 649831017659 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 649831017660 SAM binding site [chemical binding]; other site 649831017661 active site 649831017662 homodimer interface [polypeptide binding]; other site 649831017663 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 649831017664 active site 649831017665 SAM binding site [chemical binding]; other site 649831017666 homodimer interface [polypeptide binding]; other site 649831017667 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 649831017668 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 649831017669 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 649831017670 active site 649831017671 SAM binding site [chemical binding]; other site 649831017672 homodimer interface [polypeptide binding]; other site 649831017673 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 649831017674 active site 649831017675 putative homodimer interface [polypeptide binding]; other site 649831017676 SAM binding site [chemical binding]; other site 649831017677 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 649831017678 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649831017679 S-adenosylmethionine binding site [chemical binding]; other site 649831017680 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 649831017681 active site 649831017682 catalytic site [active] 649831017683 Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097 649831017684 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 649831017685 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 649831017686 FAD binding pocket [chemical binding]; other site 649831017687 FAD binding motif [chemical binding]; other site 649831017688 phosphate binding motif [ion binding]; other site 649831017689 beta-alpha-beta structure motif; other site 649831017690 NAD binding pocket [chemical binding]; other site 649831017691 FMN-binding domain; Region: FMN_bind; cl01081 649831017692 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 649831017693 ApbE family; Region: ApbE; pfam02424 649831017694 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 649831017695 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 649831017696 Coenzyme A binding pocket [chemical binding]; other site 649831017697 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649831017698 S-adenosylmethionine binding site [chemical binding]; other site 649831017699 Uncharacterized bacterial family of heme peroxidases; Region: An_peroxidase_bacterial_1; cd09819 649831017700 putative heme binding site [chemical binding]; other site 649831017701 putative substrate binding site [chemical binding]; other site 649831017702 AAA ATPase domain; Region: AAA_16; pfam13191 649831017703 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649831017704 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649831017705 DNA binding residues [nucleotide binding] 649831017706 dimerization interface [polypeptide binding]; other site 649831017707 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 649831017708 hydrophobic ligand binding site; other site 649831017709 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 649831017710 RibD C-terminal domain; Region: RibD_C; cl17279 649831017711 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 649831017712 dimerization interface [polypeptide binding]; other site 649831017713 putative DNA binding site [nucleotide binding]; other site 649831017714 putative Zn2+ binding site [ion binding]; other site 649831017715 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 649831017716 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 649831017717 active site 649831017718 IPT/TIG domain; Region: TIG; pfam01833 649831017719 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102 649831017720 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 649831017721 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 649831017722 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 649831017723 binding surface 649831017724 TPR motif; other site 649831017725 Tetratricopeptide repeat; Region: TPR_12; pfam13424 649831017726 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 649831017727 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 649831017728 metal binding site [ion binding]; metal-binding site 649831017729 active site 649831017730 I-site; other site 649831017731 Uncharacterized bacterial family of heme peroxidases; Region: An_peroxidase_bacterial_1; cd09819 649831017732 putative heme binding site [chemical binding]; other site 649831017733 putative substrate binding site [chemical binding]; other site 649831017734 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 649831017735 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 649831017736 Transport protein; Region: actII; TIGR00833 649831017737 Transport protein; Region: actII; TIGR00833 649831017738 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 649831017739 dimerization interface [polypeptide binding]; other site 649831017740 DNA binding residues [nucleotide binding] 649831017741 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 649831017742 nucleotide binding site [chemical binding]; other site 649831017743 PAS domain S-box; Region: sensory_box; TIGR00229 649831017744 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 649831017745 putative active site [active] 649831017746 heme pocket [chemical binding]; other site 649831017747 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 649831017748 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 649831017749 metal binding site [ion binding]; metal-binding site 649831017750 active site 649831017751 I-site; other site 649831017752 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 649831017753 Putative sensor; Region: Sensor; pfam13796 649831017754 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 649831017755 Histidine kinase; Region: HisKA_3; pfam07730 649831017756 Fatty acid desaturase; Region: FA_desaturase; pfam00487 649831017757 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 649831017758 putative di-iron ligands [ion binding]; other site 649831017759 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 649831017760 Coenzyme A binding pocket [chemical binding]; other site 649831017761 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 649831017762 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 649831017763 Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_1; cd05974 649831017764 active site 649831017765 acyl-activating enzyme (AAE) consensus motif; other site 649831017766 putative CoA binding site [chemical binding]; other site 649831017767 AMP binding site [chemical binding]; other site 649831017768 short chain dehydrogenase; Provisional; Region: PRK06523 649831017769 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831017770 NAD(P) binding site [chemical binding]; other site 649831017771 active site 649831017772 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649831017773 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831017774 active site 649831017775 phosphorylation site [posttranslational modification] 649831017776 intermolecular recognition site; other site 649831017777 dimerization interface [polypeptide binding]; other site 649831017778 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649831017779 DNA binding residues [nucleotide binding] 649831017780 dimerization interface [polypeptide binding]; other site 649831017781 Histidine kinase; Region: HisKA_3; pfam07730 649831017782 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 649831017783 ATP binding site [chemical binding]; other site 649831017784 Mg2+ binding site [ion binding]; other site 649831017785 G-X-G motif; other site 649831017786 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cd00413 649831017787 active site 649831017788 catalytic residues [active] 649831017789 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 649831017790 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649831017791 dimer interface [polypeptide binding]; other site 649831017792 conserved gate region; other site 649831017793 putative PBP binding loops; other site 649831017794 ABC-ATPase subunit interface; other site 649831017795 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649831017796 putative PBP binding loops; other site 649831017797 dimer interface [polypeptide binding]; other site 649831017798 ABC-ATPase subunit interface; other site 649831017799 carbohydrate ABC transporter, N-acetylglucosamine/diacetylchitobiose-binding protein; Region: chitin_NgcE; TIGR03851 649831017800 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 649831017801 hypothetical protein; Provisional; Region: PRK02947 649831017802 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 649831017803 putative active site [active] 649831017804 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 649831017805 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 649831017806 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 649831017807 putative active site [active] 649831017808 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 649831017809 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 649831017810 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 649831017811 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 649831017812 tetramer interface [polypeptide binding]; other site 649831017813 pyridoxal 5'-phosphate binding site [chemical binding]; other site 649831017814 catalytic residue [active] 649831017815 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 649831017816 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 649831017817 NAD(P) binding site [chemical binding]; other site 649831017818 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 649831017819 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 649831017820 metal binding site [ion binding]; metal-binding site 649831017821 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 649831017822 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649831017823 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649831017824 DNA binding residues [nucleotide binding] 649831017825 dimerization interface [polypeptide binding]; other site 649831017826 AMP-binding domain protein; Validated; Region: PRK08315 649831017827 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 649831017828 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 649831017829 acyl-activating enzyme (AAE) consensus motif; other site 649831017830 acyl-activating enzyme (AAE) consensus motif; other site 649831017831 putative AMP binding site [chemical binding]; other site 649831017832 putative active site [active] 649831017833 putative CoA binding site [chemical binding]; other site 649831017834 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 649831017835 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 649831017836 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 649831017837 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 649831017838 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 649831017839 Lsr2; Region: Lsr2; pfam11774 649831017840 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 649831017841 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 649831017842 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 649831017843 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 649831017844 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 649831017845 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 649831017846 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 649831017847 catalytic loop [active] 649831017848 iron binding site [ion binding]; other site 649831017849 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 649831017850 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 649831017851 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831017852 NAD(P) binding site [chemical binding]; other site 649831017853 active site 649831017854 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; pfam03767 649831017855 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 649831017856 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 649831017857 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 649831017858 DNA binding residues [nucleotide binding] 649831017859 Transcriptional regulators [Transcription]; Region: GntR; COG1802 649831017860 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 649831017861 DNA-binding site [nucleotide binding]; DNA binding site 649831017862 FCD domain; Region: FCD; pfam07729 649831017863 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 649831017864 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 649831017865 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 649831017866 hypothetical protein; Provisional; Region: PRK05463 649831017867 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 649831017868 putative active site [active] 649831017869 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 649831017870 Predicted methyltransferase [General function prediction only]; Region: COG3897 649831017871 PAS domain S-box; Region: sensory_box; TIGR00229 649831017872 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 649831017873 putative active site [active] 649831017874 heme pocket [chemical binding]; other site 649831017875 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 649831017876 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 649831017877 metal binding site [ion binding]; metal-binding site 649831017878 active site 649831017879 I-site; other site 649831017880 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 649831017881 BODYGUARD 1 domain containing hydrolase; Provisional; Region: PLN03087 649831017882 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 649831017883 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 649831017884 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 649831017885 motif II; other site 649831017886 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 649831017887 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 649831017888 minor groove reading motif; other site 649831017889 helix-hairpin-helix signature motif; other site 649831017890 active site 649831017891 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 649831017892 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 649831017893 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 649831017894 Putative zinc-finger; Region: zf-HC2; pfam13490 649831017895 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 649831017896 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 649831017897 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 649831017898 DNA binding residues [nucleotide binding] 649831017899 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2380 649831017900 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649831017901 AAA domain; Region: AAA_23; pfam13476 649831017902 Walker A/P-loop; other site 649831017903 ATP binding site [chemical binding]; other site 649831017904 Q-loop/lid; other site 649831017905 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 649831017906 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649831017907 ABC transporter signature motif; other site 649831017908 Walker B; other site 649831017909 D-loop; other site 649831017910 H-loop/switch region; other site 649831017911 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 649831017912 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 649831017913 active site 649831017914 metal binding site [ion binding]; metal-binding site 649831017915 DNA binding site [nucleotide binding] 649831017916 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 649831017917 HerA helicase [Replication, recombination, and repair]; Region: COG0433 649831017918 hypothetical protein; Provisional; Region: PRK14059 649831017919 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 649831017920 Transcriptional regulators [Transcription]; Region: PurR; COG1609 649831017921 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 649831017922 DNA binding site [nucleotide binding] 649831017923 domain linker motif; other site 649831017924 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 649831017925 putative dimerization interface [polypeptide binding]; other site 649831017926 putative ligand binding site [chemical binding]; other site 649831017927 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 649831017928 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cd02116 649831017929 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 649831017930 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 649831017931 Coenzyme A binding pocket [chemical binding]; other site 649831017932 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 649831017933 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 649831017934 Domain of unknown function DUF21; Region: DUF21; pfam01595 649831017935 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 649831017936 Transporter associated domain; Region: CorC_HlyC; smart01091 649831017937 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 649831017938 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 649831017939 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 649831017940 GAF domain; Region: GAF; pfam01590 649831017941 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 649831017942 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 649831017943 substrate binding site [chemical binding]; other site 649831017944 ATP binding site [chemical binding]; other site 649831017945 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 649831017946 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 649831017947 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 649831017948 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 649831017949 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 649831017950 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 649831017951 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 649831017952 deoxyguanosinetriphosphate triphosphohydrolase, putative; Region: dGTP_triPase; TIGR01353 649831017953 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 649831017954 Zn2+ binding site [ion binding]; other site 649831017955 Mg2+ binding site [ion binding]; other site 649831017956 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 649831017957 Protein of unknown function (DUF3037); Region: DUF3037; pfam11236 649831017958 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 649831017959 Old yellow enzyme (OYE)-related FMN binding domain, group 5. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747 649831017960 putative active site [active] 649831017961 putative FMN binding site [chemical binding]; other site 649831017962 putative substrate binding site [chemical binding]; other site 649831017963 putative catalytic residue [active] 649831017964 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831017965 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 649831017966 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 649831017967 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 649831017968 inhibitor-cofactor binding pocket; inhibition site 649831017969 pyridoxal 5'-phosphate binding site [chemical binding]; other site 649831017970 catalytic residue [active] 649831017971 Transcriptional regulator [Transcription]; Region: LysR; COG0583 649831017972 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 649831017973 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 649831017974 putative dimerization interface [polypeptide binding]; other site 649831017975 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 649831017976 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 649831017977 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 649831017978 DNA binding residues [nucleotide binding] 649831017979 drug binding residues [chemical binding]; other site 649831017980 dimer interface [polypeptide binding]; other site 649831017981 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 649831017982 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831017983 NAD(P) binding site [chemical binding]; other site 649831017984 active site 649831017985 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 649831017986 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 649831017987 active site 649831017988 DNA binding site [nucleotide binding] 649831017989 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 649831017990 DNA binding site [nucleotide binding] 649831017991 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 649831017992 TAP-like protein; Region: Abhydrolase_4; pfam08386 649831017993 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 649831017994 nucleotide binding site [chemical binding]; other site 649831017995 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 649831017996 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 649831017997 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 649831017998 short chain dehydrogenase; Provisional; Region: PRK06500 649831017999 classical (c) SDRs; Region: SDR_c; cd05233 649831018000 NAD(P) binding site [chemical binding]; other site 649831018001 active site 649831018002 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 649831018003 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 649831018004 dimerization interface [polypeptide binding]; other site 649831018005 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 649831018006 Coenzyme A binding pocket [chemical binding]; other site 649831018007 N-terminal Early set domain associated with the catalytic domain of isoamylase-like (also called glycogen 6-glucanohydrolase) proteins; Region: E_set_Isoamylase_like_N; cd07184 649831018008 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 649831018009 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 649831018010 Domain of unknown function (DUF397); Region: DUF397; pfam04149 649831018011 thymidylate synthase; Reviewed; Region: thyA; PRK01827 649831018012 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 649831018013 dimerization interface [polypeptide binding]; other site 649831018014 active site 649831018015 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 649831018016 substrate binding site [chemical binding]; other site 649831018017 active site 649831018018 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 649831018019 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 649831018020 putative active site [active] 649831018021 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 649831018022 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 649831018023 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 649831018024 catalytic site [active] 649831018025 putative active site [active] 649831018026 putative substrate binding site [chemical binding]; other site 649831018027 Helicase and RNase D C-terminal; Region: HRDC; smart00341 649831018028 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 649831018029 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 649831018030 dimer interface [polypeptide binding]; other site 649831018031 active site 649831018032 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 649831018033 substrate binding site [chemical binding]; other site 649831018034 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 649831018035 oxyanion hole (OAH) forming residues; other site 649831018036 trimer interface [polypeptide binding]; other site 649831018037 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 649831018038 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 649831018039 NADH dehydrogenase subunit E; Provisional; Region: PRK12373 649831018040 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 649831018041 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 649831018042 dimerization interface [polypeptide binding]; other site 649831018043 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 649831018044 dimer interface [polypeptide binding]; other site 649831018045 phosphorylation site [posttranslational modification] 649831018046 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831018047 ATP binding site [chemical binding]; other site 649831018048 Mg2+ binding site [ion binding]; other site 649831018049 G-X-G motif; other site 649831018050 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 649831018051 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831018052 active site 649831018053 phosphorylation site [posttranslational modification] 649831018054 intermolecular recognition site; other site 649831018055 dimerization interface [polypeptide binding]; other site 649831018056 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 649831018057 DNA binding site [nucleotide binding] 649831018058 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 649831018059 Trp docking motif [polypeptide binding]; other site 649831018060 PQQ-like domain; Region: PQQ_2; pfam13360 649831018061 active site 649831018062 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 649831018063 PQQ-like domain; Region: PQQ_2; pfam13360 649831018064 Trp docking motif [polypeptide binding]; other site 649831018065 active site 649831018066 PQQ-like domain; Region: PQQ_2; pfam13360 649831018067 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 649831018068 Trp docking motif [polypeptide binding]; other site 649831018069 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 649831018070 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 649831018071 TPP-binding site; other site 649831018072 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 649831018073 PYR/PP interface [polypeptide binding]; other site 649831018074 dimer interface [polypeptide binding]; other site 649831018075 TPP binding site [chemical binding]; other site 649831018076 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 649831018077 TRAM domain; Region: TRAM; pfam01938 649831018078 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 649831018079 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 649831018080 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 649831018081 TrkA-N domain; Region: TrkA_N; pfam02254 649831018082 TrkA-C domain; Region: TrkA_C; pfam02080 649831018083 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 649831018084 TrkA-N domain; Region: TrkA_N; pfam02254 649831018085 TrkA-C domain; Region: TrkA_C; pfam02080 649831018086 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 649831018087 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 649831018088 ssDNA binding site; other site 649831018089 generic binding surface II; other site 649831018090 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 649831018091 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 649831018092 trimer interface [polypeptide binding]; other site 649831018093 active site 649831018094 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 649831018095 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 649831018096 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 649831018097 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 649831018098 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 649831018099 active site 649831018100 dimerization interface [polypeptide binding]; other site 649831018101 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 649831018102 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 649831018103 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 649831018104 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 649831018105 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 649831018106 DNA binding residues [nucleotide binding] 649831018107 Domain of unknown function (DUF4267); Region: DUF4267; pfam14087 649831018108 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 649831018109 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 649831018110 ATP binding site [chemical binding]; other site 649831018111 putative Mg++ binding site [ion binding]; other site 649831018112 Predicted membrane protein [Function unknown]; Region: COG2860 649831018113 UPF0126 domain; Region: UPF0126; pfam03458 649831018114 UPF0126 domain; Region: UPF0126; pfam03458 649831018115 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 649831018116 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 649831018117 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 649831018118 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 649831018119 substrate binding site [chemical binding]; other site 649831018120 ATP binding site [chemical binding]; other site 649831018121 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 649831018122 CHASE domain; Region: CHASE; cl01369 649831018123 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 649831018124 metal binding site [ion binding]; metal-binding site 649831018125 active site 649831018126 I-site; other site 649831018127 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 649831018128 CHASE domain; Region: CHASE; cl01369 649831018129 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 649831018130 metal binding site [ion binding]; metal-binding site 649831018131 active site 649831018132 I-site; other site 649831018133 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 649831018134 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 649831018135 active site 649831018136 substrate binding site [chemical binding]; other site 649831018137 ATP binding site [chemical binding]; other site 649831018138 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 649831018139 putative active site [active] 649831018140 dimerization interface [polypeptide binding]; other site 649831018141 putative tRNAtyr binding site [nucleotide binding]; other site 649831018142 Fructosamine kinase; Region: Fructosamin_kin; cl17579 649831018143 Phosphotransferase enzyme family; Region: APH; pfam01636 649831018144 SpoOM protein; Region: Spo0M; pfam07070 649831018145 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 649831018146 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 649831018147 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 649831018148 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 649831018149 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 649831018150 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 649831018151 DNA binding residues [nucleotide binding] 649831018152 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 649831018153 Catalytic site [active] 649831018154 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 649831018155 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 649831018156 Coenzyme A binding pocket [chemical binding]; other site 649831018157 CoA binding domain; Region: CoA_binding_2; pfam13380 649831018158 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 649831018159 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 649831018160 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 649831018161 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 649831018162 active site 649831018163 Zn binding site [ion binding]; other site 649831018164 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 649831018165 Interdomain contacts; other site 649831018166 Cytokine receptor motif; other site 649831018167 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 649831018168 Interdomain contacts; other site 649831018169 Cytokine receptor motif; other site 649831018170 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 649831018171 Interdomain contacts; other site 649831018172 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 649831018173 ligand binding site [chemical binding]; other site 649831018174 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 649831018175 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 649831018176 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 649831018177 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 649831018178 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 649831018179 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 649831018180 TIGR03086 family protein; Region: TIGR03086 649831018181 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 649831018182 Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A; Region: PNGaseA; pfam12222 649831018183 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831018184 putative substrate translocation pore; other site 649831018185 Major Facilitator Superfamily; Region: MFS_1; pfam07690 649831018186 vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556 649831018187 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 649831018188 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 649831018189 active site 649831018190 dimer interface [polypeptide binding]; other site 649831018191 effector binding site; other site 649831018192 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 649831018193 TSCPD domain; Region: TSCPD; pfam12637 649831018194 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 649831018195 ATP cone domain; Region: ATP-cone; pfam03477 649831018196 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 649831018197 LexA repressor; Validated; Region: PRK00215 649831018198 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 649831018199 putative switch regulator; other site 649831018200 non-specific DNA interactions [nucleotide binding]; other site 649831018201 DNA binding site [nucleotide binding] 649831018202 sequence specific DNA binding site [nucleotide binding]; other site 649831018203 putative cAMP binding site [chemical binding]; other site 649831018204 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 649831018205 Catalytic site [active] 649831018206 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 649831018207 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 649831018208 putative metal binding site [ion binding]; other site 649831018209 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 649831018210 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 649831018211 HflX GTPase family; Region: HflX; cd01878 649831018212 G1 box; other site 649831018213 GTP/Mg2+ binding site [chemical binding]; other site 649831018214 Switch I region; other site 649831018215 G2 box; other site 649831018216 G3 box; other site 649831018217 Switch II region; other site 649831018218 G4 box; other site 649831018219 G5 box; other site 649831018220 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 649831018221 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 649831018222 Malic enzyme, N-terminal domain; Region: malic; pfam00390 649831018223 Malic enzyme, NAD binding domain; Region: Malic_M; smart00919 649831018224 NAD(P) binding pocket [chemical binding]; other site 649831018225 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 649831018226 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 649831018227 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 649831018228 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 649831018229 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 649831018230 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 649831018231 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 649831018232 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 649831018233 putative hydrophobic ligand binding site [chemical binding]; other site 649831018234 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 649831018235 dimerization interface [polypeptide binding]; other site 649831018236 putative DNA binding site [nucleotide binding]; other site 649831018237 putative Zn2+ binding site [ion binding]; other site 649831018238 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 649831018239 apolar tunnel; other site 649831018240 heme binding site [chemical binding]; other site 649831018241 dimerization interface [polypeptide binding]; other site 649831018242 Predicted transcriptional regulators [Transcription]; Region: COG1733 649831018243 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 649831018244 dimerization interface [polypeptide binding]; other site 649831018245 putative DNA binding site [nucleotide binding]; other site 649831018246 putative Zn2+ binding site [ion binding]; other site 649831018247 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 649831018248 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 649831018249 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 649831018250 FeS/SAM binding site; other site 649831018251 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 649831018252 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 649831018253 Walker A/P-loop; other site 649831018254 ATP binding site [chemical binding]; other site 649831018255 Q-loop/lid; other site 649831018256 ABC transporter signature motif; other site 649831018257 Walker B; other site 649831018258 D-loop; other site 649831018259 H-loop/switch region; other site 649831018260 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 649831018261 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 649831018262 substrate binding pocket [chemical binding]; other site 649831018263 membrane-bound complex binding site; other site 649831018264 hinge residues; other site 649831018265 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649831018266 dimer interface [polypeptide binding]; other site 649831018267 conserved gate region; other site 649831018268 putative PBP binding loops; other site 649831018269 ABC-ATPase subunit interface; other site 649831018270 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649831018271 dimer interface [polypeptide binding]; other site 649831018272 conserved gate region; other site 649831018273 putative PBP binding loops; other site 649831018274 ABC-ATPase subunit interface; other site 649831018275 phosphodiesterase; Provisional; Region: PRK12704 649831018276 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 649831018277 Zn2+ binding site [ion binding]; other site 649831018278 Mg2+ binding site [ion binding]; other site 649831018279 recombination regulator RecX; Reviewed; Region: recX; PRK00117 649831018280 recombinase A; Provisional; Region: recA; PRK09354 649831018281 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 649831018282 hexamer interface [polypeptide binding]; other site 649831018283 Walker A motif; other site 649831018284 ATP binding site [chemical binding]; other site 649831018285 Walker B motif; other site 649831018286 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 649831018287 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 649831018288 Fe-S cluster binding site [ion binding]; other site 649831018289 active site 649831018290 transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481 649831018291 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 649831018292 DNA-binding site [nucleotide binding]; DNA binding site 649831018293 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 649831018294 pyridoxal 5'-phosphate binding site [chemical binding]; other site 649831018295 homodimer interface [polypeptide binding]; other site 649831018296 catalytic residue [active] 649831018297 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 649831018298 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 649831018299 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 649831018300 DoxX; Region: DoxX; pfam07681 649831018301 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 649831018302 SpoOM protein; Region: Spo0M; pfam07070 649831018303 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 649831018304 Domain of unknown function DUF21; Region: DUF21; pfam01595 649831018305 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 649831018306 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 649831018307 Domain of unknown function DUF21; Region: DUF21; pfam01595 649831018308 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 649831018309 Transporter associated domain; Region: CorC_HlyC; smart01091 649831018310 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 649831018311 Catalytic domain of Protein Kinases; Region: PKc; cd00180 649831018312 active site 649831018313 ATP binding site [chemical binding]; other site 649831018314 substrate binding site [chemical binding]; other site 649831018315 activation loop (A-loop); other site 649831018316 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 649831018317 active site 649831018318 putative catalytic site [active] 649831018319 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 649831018320 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 649831018321 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 649831018322 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 649831018323 ATP binding site [chemical binding]; other site 649831018324 putative Mg++ binding site [ion binding]; other site 649831018325 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 649831018326 nucleotide binding region [chemical binding]; other site 649831018327 ATP-binding site [chemical binding]; other site 649831018328 DEAD/H associated; Region: DEAD_assoc; pfam08494 649831018329 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 649831018330 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 649831018331 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 649831018332 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 649831018333 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 649831018334 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 649831018335 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 649831018336 putative DNA binding site [nucleotide binding]; other site 649831018337 catalytic residue [active] 649831018338 putative H2TH interface [polypeptide binding]; other site 649831018339 putative catalytic residues [active] 649831018340 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 649831018341 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 649831018342 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 649831018343 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 649831018344 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 649831018345 non-specific DNA binding site [nucleotide binding]; other site 649831018346 salt bridge; other site 649831018347 sequence-specific DNA binding site [nucleotide binding]; other site 649831018348 Competence-damaged protein; Region: CinA; pfam02464 649831018349 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 649831018350 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 649831018351 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 649831018352 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 649831018353 FeS/SAM binding site; other site 649831018354 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 649831018355 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 649831018356 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 649831018357 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 649831018358 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 649831018359 Alpha-lytic protease prodomain; Region: Pro_Al_protease; pfam02983 649831018360 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 649831018361 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 649831018362 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 649831018363 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 649831018364 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 649831018365 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 649831018366 dimer interface [polypeptide binding]; other site 649831018367 active site 649831018368 catalytic residue [active] 649831018369 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 649831018370 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 649831018371 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 649831018372 dihydrodipicolinate reductase; Provisional; Region: PRK00048 649831018373 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 649831018374 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 649831018375 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 649831018376 active site 649831018377 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 649831018378 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 649831018379 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 649831018380 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 649831018381 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 649831018382 RNase E interface [polypeptide binding]; other site 649831018383 trimer interface [polypeptide binding]; other site 649831018384 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 649831018385 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 649831018386 RNase E interface [polypeptide binding]; other site 649831018387 trimer interface [polypeptide binding]; other site 649831018388 active site 649831018389 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 649831018390 putative nucleic acid binding region [nucleotide binding]; other site 649831018391 G-X-X-G motif; other site 649831018392 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 649831018393 RNA binding site [nucleotide binding]; other site 649831018394 domain interface; other site 649831018395 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 649831018396 16S/18S rRNA binding site [nucleotide binding]; other site 649831018397 S13e-L30e interaction site [polypeptide binding]; other site 649831018398 25S rRNA binding site [nucleotide binding]; other site 649831018399 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 649831018400 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 649831018401 active site 649831018402 Riboflavin kinase; Region: Flavokinase; pfam01687 649831018403 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 649831018404 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 649831018405 dimer interface [polypeptide binding]; other site 649831018406 phosphorylation site [posttranslational modification] 649831018407 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831018408 ATP binding site [chemical binding]; other site 649831018409 Mg2+ binding site [ion binding]; other site 649831018410 G-X-G motif; other site 649831018411 Response regulator receiver domain; Region: Response_reg; pfam00072 649831018412 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831018413 active site 649831018414 phosphorylation site [posttranslational modification] 649831018415 intermolecular recognition site; other site 649831018416 dimerization interface [polypeptide binding]; other site 649831018417 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831018418 active site 649831018419 phosphorylation site [posttranslational modification] 649831018420 intermolecular recognition site; other site 649831018421 Response regulator receiver domain; Region: Response_reg; pfam00072 649831018422 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831018423 active site 649831018424 phosphorylation site [posttranslational modification] 649831018425 intermolecular recognition site; other site 649831018426 dimerization interface [polypeptide binding]; other site 649831018427 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 649831018428 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 649831018429 RNA binding site [nucleotide binding]; other site 649831018430 active site 649831018431 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 649831018432 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 649831018433 putative efflux protein, MATE family; Region: matE; TIGR00797 649831018434 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 649831018435 DHH family; Region: DHH; pfam01368 649831018436 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 649831018437 Protein of unknown function (DUF503); Region: DUF503; cl00669 649831018438 Methyltransferase domain; Region: Methyltransf_26; pfam13659 649831018439 translation initiation factor IF-2; Region: IF-2; TIGR00487 649831018440 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 649831018441 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 649831018442 G1 box; other site 649831018443 putative GEF interaction site [polypeptide binding]; other site 649831018444 GTP/Mg2+ binding site [chemical binding]; other site 649831018445 Switch I region; other site 649831018446 G2 box; other site 649831018447 G3 box; other site 649831018448 Switch II region; other site 649831018449 G4 box; other site 649831018450 G5 box; other site 649831018451 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 649831018452 Translation-initiation factor 2; Region: IF-2; pfam11987 649831018453 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 649831018454 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 649831018455 NusA N-terminal domain; Region: NusA_N; pfam08529 649831018456 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 649831018457 RNA binding site [nucleotide binding]; other site 649831018458 homodimer interface [polypeptide binding]; other site 649831018459 NusA-like KH domain; Region: KH_5; pfam13184 649831018460 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 649831018461 G-X-X-G motif; other site 649831018462 ribosome maturation protein RimP; Reviewed; Region: PRK00092 649831018463 Sm and related proteins; Region: Sm_like; cl00259 649831018464 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 649831018465 putative oligomer interface [polypeptide binding]; other site 649831018466 putative RNA binding site [nucleotide binding]; other site 649831018467 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 649831018468 dinuclear metal binding motif [ion binding]; other site 649831018469 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 649831018470 active site 649831018471 NTP binding site [chemical binding]; other site 649831018472 metal binding triad [ion binding]; metal-binding site 649831018473 antibiotic binding site [chemical binding]; other site 649831018474 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 649831018475 active site 649831018476 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 649831018477 anti sigma factor interaction site; other site 649831018478 regulatory phosphorylation site [posttranslational modification]; other site 649831018479 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 649831018480 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 649831018481 dimer interface [polypeptide binding]; other site 649831018482 phosphorylation site [posttranslational modification] 649831018483 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831018484 ATP binding site [chemical binding]; other site 649831018485 Mg2+ binding site [ion binding]; other site 649831018486 G-X-G motif; other site 649831018487 Response regulator receiver domain; Region: Response_reg; pfam00072 649831018488 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831018489 active site 649831018490 phosphorylation site [posttranslational modification] 649831018491 intermolecular recognition site; other site 649831018492 dimerization interface [polypeptide binding]; other site 649831018493 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 649831018494 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 649831018495 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 649831018496 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680 649831018497 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 649831018498 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 649831018499 catalytic triad [active] 649831018500 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 649831018501 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 649831018502 catalytic triad [active] 649831018503 short chain dehydrogenase; Provisional; Region: PRK06057 649831018504 classical (c) SDRs; Region: SDR_c; cd05233 649831018505 NAD(P) binding site [chemical binding]; other site 649831018506 active site 649831018507 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 649831018508 NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078 649831018509 NAD(P) binding site [chemical binding]; other site 649831018510 catalytic residues [active] 649831018511 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 649831018512 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 649831018513 amino acid permease (GABA permease); Region: 2A0304; TIGR00907 649831018514 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 649831018515 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 649831018516 DNA binding residues [nucleotide binding] 649831018517 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831018518 NAD(P) binding site [chemical binding]; other site 649831018519 active site 649831018520 Protein of unknown function (DUF998); Region: DUF998; pfam06197 649831018521 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 649831018522 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649831018523 Walker A/P-loop; other site 649831018524 ATP binding site [chemical binding]; other site 649831018525 Q-loop/lid; other site 649831018526 ABC transporter signature motif; other site 649831018527 Walker B; other site 649831018528 D-loop; other site 649831018529 H-loop/switch region; other site 649831018530 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 649831018531 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 649831018532 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 649831018533 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831018534 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 649831018535 Predicted membrane protein [Function unknown]; Region: COG1511 649831018536 Predicted membrane protein [Function unknown]; Region: COG1511 649831018537 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 649831018538 heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189 649831018539 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 649831018540 Walker A/P-loop; other site 649831018541 ATP binding site [chemical binding]; other site 649831018542 Q-loop/lid; other site 649831018543 ABC transporter signature motif; other site 649831018544 Walker B; other site 649831018545 D-loop; other site 649831018546 H-loop/switch region; other site 649831018547 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 649831018548 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 649831018549 Predicted transcriptional regulators [Transcription]; Region: COG1695 649831018550 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 649831018551 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 649831018552 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 649831018553 Coenzyme A binding pocket [chemical binding]; other site 649831018554 Domain of unknown function (DUF4037); Region: DUF4037; pfam13228 649831018555 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 649831018556 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 649831018557 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 649831018558 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 649831018559 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 649831018560 active site 649831018561 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 649831018562 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 649831018563 putative substrate binding region [chemical binding]; other site 649831018564 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 649831018565 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 649831018566 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 649831018567 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 649831018568 MMPL family; Region: MMPL; pfam03176 649831018569 MMPL family; Region: MMPL; pfam03176 649831018570 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 649831018571 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 649831018572 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 649831018573 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 649831018574 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 649831018575 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 649831018576 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 649831018577 iron-sulfur cluster [ion binding]; other site 649831018578 [2Fe-2S] cluster binding site [ion binding]; other site 649831018579 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 649831018580 DivIVA domain; Region: DivI1A_domain; TIGR03544 649831018581 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 649831018582 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 649831018583 FeS/SAM binding site; other site 649831018584 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 649831018585 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 649831018586 ribosome recycling factor; Reviewed; Region: frr; PRK00083 649831018587 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 649831018588 hinge region; other site 649831018589 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 649831018590 putative nucleotide binding site [chemical binding]; other site 649831018591 uridine monophosphate binding site [chemical binding]; other site 649831018592 homohexameric interface [polypeptide binding]; other site 649831018593 elongation factor Ts; Provisional; Region: tsf; PRK09377 649831018594 UBA/TS-N domain; Region: UBA; pfam00627 649831018595 Elongation factor TS; Region: EF_TS; pfam00889 649831018596 Elongation factor TS; Region: EF_TS; pfam00889 649831018597 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 649831018598 rRNA interaction site [nucleotide binding]; other site 649831018599 S8 interaction site; other site 649831018600 putative laminin-1 binding site; other site 649831018601 hypothetical protein; Reviewed; Region: PRK12497 649831018602 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 649831018603 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 649831018604 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 649831018605 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 649831018606 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 649831018607 DNA protecting protein DprA; Region: dprA; TIGR00732 649831018608 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 649831018609 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 649831018610 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 649831018611 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 649831018612 active site 649831018613 DNA binding site [nucleotide binding] 649831018614 Int/Topo IB signature motif; other site 649831018615 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 649831018616 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 649831018617 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 649831018618 catalytic residue [active] 649831018619 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 649831018620 Peptidase family M23; Region: Peptidase_M23; pfam01551 649831018621 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 649831018622 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 649831018623 RNA/DNA hybrid binding site [nucleotide binding]; other site 649831018624 active site 649831018625 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685 649831018626 nudix motif; other site 649831018627 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 649831018628 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 649831018629 Catalytic site [active] 649831018630 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 649831018631 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 649831018632 Catalytic site [active] 649831018633 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 649831018634 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 649831018635 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 649831018636 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 649831018637 RimM N-terminal domain; Region: RimM; pfam01782 649831018638 PRC-barrel domain; Region: PRC; pfam05239 649831018639 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 649831018640 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 649831018641 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 649831018642 Protein of unknown function (DUF402); Region: DUF402; pfam04167 649831018643 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 649831018644 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 649831018645 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 649831018646 DNA binding residues [nucleotide binding] 649831018647 PQQ-like domain; Region: PQQ_2; pfam13360 649831018648 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 649831018649 active site 649831018650 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 649831018651 putative active site [active] 649831018652 signal recognition particle protein; Provisional; Region: PRK10867 649831018653 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 649831018654 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 649831018655 P loop; other site 649831018656 GTP binding site [chemical binding]; other site 649831018657 Signal peptide binding domain; Region: SRP_SPB; pfam02978 649831018658 Protein of unknown function (DUF3184); Region: DUF3184; pfam11380 649831018659 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 649831018660 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831018661 NAD(P) binding site [chemical binding]; other site 649831018662 active site 649831018663 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 649831018664 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 649831018665 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 649831018666 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 649831018667 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 649831018668 Methyltransferase domain; Region: Methyltransf_24; pfam13578 649831018669 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 649831018670 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 649831018671 active site 649831018672 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 649831018673 PII uridylyl-transferase; Provisional; Region: PRK03381 649831018674 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 649831018675 metal binding triad; other site 649831018676 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 649831018677 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 649831018678 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 649831018679 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 649831018680 Nitrogen regulatory protein P-II; Region: P-II; smart00938 649831018681 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 649831018682 Phosphotransferase enzyme family; Region: APH; pfam01636 649831018683 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 649831018684 active site 649831018685 ATP binding site [chemical binding]; other site 649831018686 substrate binding site [chemical binding]; other site 649831018687 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 649831018688 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 649831018689 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 649831018690 GTP binding site [chemical binding]; other site 649831018691 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 649831018692 putative active site [active] 649831018693 putative metal binding site [ion binding]; other site 649831018694 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 649831018695 Protein of unknown function (DUF664); Region: DUF664; pfam04978 649831018696 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 649831018697 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 649831018698 motif II; other site 649831018699 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 649831018700 AAA domain; Region: AAA_23; pfam13476 649831018701 Walker A/P-loop; other site 649831018702 ATP binding site [chemical binding]; other site 649831018703 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 649831018704 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 649831018705 ABC transporter signature motif; other site 649831018706 Walker B; other site 649831018707 D-loop; other site 649831018708 H-loop/switch region; other site 649831018709 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK12323 649831018710 transcription termination factor Rho; Provisional; Region: PRK12678 649831018711 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 649831018712 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 649831018713 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 649831018714 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 649831018715 DNA binding site [nucleotide binding] 649831018716 catalytic residue [active] 649831018717 H2TH interface [polypeptide binding]; other site 649831018718 putative catalytic residues [active] 649831018719 turnover-facilitating residue; other site 649831018720 intercalation triad [nucleotide binding]; other site 649831018721 8OG recognition residue [nucleotide binding]; other site 649831018722 putative reading head residues; other site 649831018723 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 649831018724 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 649831018725 Mannosyltransferase (PIG-V)); Region: Mannosyl_trans2; pfam04188 649831018726 ribonuclease III; Reviewed; Region: rnc; PRK00102 649831018727 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 649831018728 dimerization interface [polypeptide binding]; other site 649831018729 active site 649831018730 metal binding site [ion binding]; metal-binding site 649831018731 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 649831018732 dsRNA binding site [nucleotide binding]; other site 649831018733 Fatty acid synthesis protein; Region: FA_synthesis; cl17261 649831018734 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 649831018735 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 649831018736 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 649831018737 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 649831018738 active site 649831018739 (T/H)XGH motif; other site 649831018740 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 649831018741 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649831018742 S-adenosylmethionine binding site [chemical binding]; other site 649831018743 Protein of unknown function (DUF952); Region: DUF952; cl01393 649831018744 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 649831018745 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 649831018746 generic binding surface II; other site 649831018747 ssDNA binding site; other site 649831018748 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 649831018749 ATP binding site [chemical binding]; other site 649831018750 putative Mg++ binding site [ion binding]; other site 649831018751 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 649831018752 nucleotide binding region [chemical binding]; other site 649831018753 ATP-binding site [chemical binding]; other site 649831018754 DAK2 domain; Region: Dak2; pfam02734 649831018755 Dihydroxyacetone kinase family; Region: Dak1_2; pfam13684 649831018756 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 649831018757 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 649831018758 Coenzyme A binding pocket [chemical binding]; other site 649831018759 thiamine monophosphate kinase; Provisional; Region: PRK05731 649831018760 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 649831018761 ATP binding site [chemical binding]; other site 649831018762 dimerization interface [polypeptide binding]; other site 649831018763 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 649831018764 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 649831018765 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 649831018766 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 649831018767 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649831018768 Walker A/P-loop; other site 649831018769 ATP binding site [chemical binding]; other site 649831018770 Q-loop/lid; other site 649831018771 ABC transporter signature motif; other site 649831018772 Walker B; other site 649831018773 D-loop; other site 649831018774 H-loop/switch region; other site 649831018775 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 649831018776 DNA-binding site [nucleotide binding]; DNA binding site 649831018777 cystathionine gamma-lyase; Validated; Region: PRK07582 649831018778 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 649831018779 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 649831018780 catalytic residue [active] 649831018781 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 649831018782 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 649831018783 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 649831018784 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 649831018785 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 649831018786 putative acyl-acceptor binding pocket; other site 649831018787 2-phospho-L-lactate guanylyltransferase; Region: F420_cofC; TIGR03552 649831018788 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 649831018789 polyphosphate kinase; Provisional; Region: PRK05443 649831018790 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 649831018791 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 649831018792 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 649831018793 putative domain interface [polypeptide binding]; other site 649831018794 putative active site [active] 649831018795 catalytic site [active] 649831018796 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 649831018797 putative domain interface [polypeptide binding]; other site 649831018798 putative active site [active] 649831018799 catalytic site [active] 649831018800 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 649831018801 active site 649831018802 Ap6A binding site [chemical binding]; other site 649831018803 nudix motif; other site 649831018804 metal binding site [ion binding]; metal-binding site 649831018805 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 649831018806 catalytic core [active] 649831018807 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 649831018808 IHF dimer interface [polypeptide binding]; other site 649831018809 IHF - DNA interface [nucleotide binding]; other site 649831018810 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 649831018811 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 649831018812 substrate binding site [chemical binding]; other site 649831018813 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 649831018814 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 649831018815 substrate binding site [chemical binding]; other site 649831018816 ligand binding site [chemical binding]; other site 649831018817 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 649831018818 Transcriptional regulator [Transcription]; Region: IclR; COG1414 649831018819 Bacterial transcriptional regulator; Region: IclR; pfam01614 649831018820 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 649831018821 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831018822 NADH(P)-binding; Region: NAD_binding_10; pfam13460 649831018823 NAD(P) binding site [chemical binding]; other site 649831018824 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831018825 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 649831018826 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 649831018827 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 649831018828 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 649831018829 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 649831018830 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 649831018831 non-specific DNA binding site [nucleotide binding]; other site 649831018832 salt bridge; other site 649831018833 sequence-specific DNA binding site [nucleotide binding]; other site 649831018834 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 649831018835 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 649831018836 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 649831018837 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 649831018838 Walker A/P-loop; other site 649831018839 ATP binding site [chemical binding]; other site 649831018840 Q-loop/lid; other site 649831018841 ABC transporter signature motif; other site 649831018842 Walker B; other site 649831018843 D-loop; other site 649831018844 H-loop/switch region; other site 649831018845 hypothetical protein; Provisional; Region: PRK09256 649831018846 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 649831018847 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 649831018848 dimerization interface [polypeptide binding]; other site 649831018849 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 649831018850 dimer interface [polypeptide binding]; other site 649831018851 phosphorylation site [posttranslational modification] 649831018852 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831018853 ATP binding site [chemical binding]; other site 649831018854 Mg2+ binding site [ion binding]; other site 649831018855 G-X-G motif; other site 649831018856 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 649831018857 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831018858 active site 649831018859 phosphorylation site [posttranslational modification] 649831018860 intermolecular recognition site; other site 649831018861 dimerization interface [polypeptide binding]; other site 649831018862 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 649831018863 DNA binding site [nucleotide binding] 649831018864 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 649831018865 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 649831018866 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 649831018867 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 649831018868 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 649831018869 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 649831018870 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 649831018871 dimerization interface [polypeptide binding]; other site 649831018872 Endonuclease/Exonuclease/phosphatase family; Region: Exo_endo_phos; pfam03372 649831018873 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 649831018874 putative catalytic site [active] 649831018875 putative phosphate binding site [ion binding]; other site 649831018876 putative metal binding site [ion binding]; other site 649831018877 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 649831018878 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 649831018879 active site 649831018880 catalytic residues [active] 649831018881 metal binding site [ion binding]; metal-binding site 649831018882 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 649831018883 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 649831018884 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 649831018885 active site 649831018886 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 649831018887 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 649831018888 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 649831018889 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 649831018890 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 649831018891 homodimer interface [polypeptide binding]; other site 649831018892 substrate-cofactor binding pocket; other site 649831018893 catalytic residue [active] 649831018894 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 649831018895 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 649831018896 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 649831018897 ligand binding site [chemical binding]; other site 649831018898 NAD binding site [chemical binding]; other site 649831018899 dimerization interface [polypeptide binding]; other site 649831018900 catalytic site [active] 649831018901 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 649831018902 putative L-serine binding site [chemical binding]; other site 649831018903 mannosyl-3-phosphoglycerate synthase; Provisional; Region: PRK14503; cl12225 649831018904 Mannosyl-3-phosphoglycerate synthase (osmo_MPGsynth); Region: Osmo_MPGsynth; pfam09488 649831018905 ketol-acid reductoisomerase; Provisional; Region: PRK05479 649831018906 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 649831018907 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 649831018908 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 649831018909 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 649831018910 putative valine binding site [chemical binding]; other site 649831018911 dimer interface [polypeptide binding]; other site 649831018912 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 649831018913 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 649831018914 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 649831018915 PYR/PP interface [polypeptide binding]; other site 649831018916 dimer interface [polypeptide binding]; other site 649831018917 TPP binding site [chemical binding]; other site 649831018918 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 649831018919 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 649831018920 TPP-binding site [chemical binding]; other site 649831018921 dimer interface [polypeptide binding]; other site 649831018922 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 649831018923 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 649831018924 metal binding site [ion binding]; metal-binding site 649831018925 active site 649831018926 I-site; other site 649831018927 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 649831018928 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 649831018929 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 649831018930 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831018931 active site 649831018932 phosphorylation site [posttranslational modification] 649831018933 intermolecular recognition site; other site 649831018934 dimerization interface [polypeptide binding]; other site 649831018935 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 649831018936 GAF domain; Region: GAF; pfam01590 649831018937 Phytochrome region; Region: PHY; pfam00360 649831018938 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 649831018939 dimer interface [polypeptide binding]; other site 649831018940 phosphorylation site [posttranslational modification] 649831018941 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831018942 ATP binding site [chemical binding]; other site 649831018943 Mg2+ binding site [ion binding]; other site 649831018944 G-X-G motif; other site 649831018945 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 649831018946 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 649831018947 putative sugar binding sites [chemical binding]; other site 649831018948 Q-X-W motif; other site 649831018949 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 649831018950 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 649831018951 active site 649831018952 HIGH motif; other site 649831018953 KMSKS motif; other site 649831018954 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 649831018955 tRNA binding surface [nucleotide binding]; other site 649831018956 anticodon binding site; other site 649831018957 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 649831018958 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 649831018959 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 649831018960 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 649831018961 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649831018962 dimer interface [polypeptide binding]; other site 649831018963 conserved gate region; other site 649831018964 putative PBP binding loops; other site 649831018965 ABC-ATPase subunit interface; other site 649831018966 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 649831018967 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649831018968 dimer interface [polypeptide binding]; other site 649831018969 conserved gate region; other site 649831018970 putative PBP binding loops; other site 649831018971 ABC-ATPase subunit interface; other site 649831018972 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 649831018973 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 649831018974 Transcriptional regulators [Transcription]; Region: PurR; COG1609 649831018975 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 649831018976 DNA binding site [nucleotide binding] 649831018977 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 649831018978 ligand binding site [chemical binding]; other site 649831018979 dimerization interface [polypeptide binding]; other site 649831018980 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 649831018981 histidinol-phosphatase; Provisional; Region: PRK05588 649831018982 active site 649831018983 PAS fold; Region: PAS; pfam00989 649831018984 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 649831018985 putative active site [active] 649831018986 heme pocket [chemical binding]; other site 649831018987 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 649831018988 metal binding site [ion binding]; metal-binding site 649831018989 active site 649831018990 I-site; other site 649831018991 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 649831018992 Ubiquitin-like proteins; Region: UBQ; cl00155 649831018993 charged pocket; other site 649831018994 hydrophobic patch; other site 649831018995 VPS10 domain; Region: VPS10; smart00602 649831018996 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 649831018997 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 649831018998 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 649831018999 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 649831019000 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 649831019001 active site 649831019002 metal binding site [ion binding]; metal-binding site 649831019003 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 649831019004 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 649831019005 GatB domain; Region: GatB_Yqey; smart00845 649831019006 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 649831019007 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 649831019008 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 649831019009 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 649831019010 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 649831019011 metal binding site [ion binding]; metal-binding site 649831019012 active site 649831019013 I-site; other site 649831019014 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 649831019015 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 649831019016 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 649831019017 nucleotide binding pocket [chemical binding]; other site 649831019018 K-X-D-G motif; other site 649831019019 catalytic site [active] 649831019020 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 649831019021 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 649831019022 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 649831019023 Dimer interface [polypeptide binding]; other site 649831019024 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 649831019025 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 649831019026 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 649831019027 Ligand Binding Site [chemical binding]; other site 649831019028 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 649831019029 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 649831019030 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 649831019031 catalytic residue [active] 649831019032 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 649831019033 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 649831019034 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 649831019035 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 649831019036 Ligand binding site [chemical binding]; other site 649831019037 Electron transfer flavoprotein domain; Region: ETF; pfam01012 649831019038 Domain of unknown function (DUF202); Region: DUF202; cl09954 649831019039 Domain of unknown function (DUF202); Region: DUF202; cl09954 649831019040 hypothetical protein; Provisional; Region: PRK05858 649831019041 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 649831019042 PYR/PP interface [polypeptide binding]; other site 649831019043 dimer interface [polypeptide binding]; other site 649831019044 TPP binding site [chemical binding]; other site 649831019045 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 649831019046 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 649831019047 TPP-binding site; other site 649831019048 dimer interface [polypeptide binding]; other site 649831019049 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 649831019050 nucleotide binding site [chemical binding]; other site 649831019051 putative NEF/HSP70 interaction site [polypeptide binding]; other site 649831019052 SBD interface [polypeptide binding]; other site 649831019053 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 649831019054 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 649831019055 substrate binding site [chemical binding]; other site 649831019056 oxyanion hole (OAH) forming residues; other site 649831019057 trimer interface [polypeptide binding]; other site 649831019058 Predicted membrane protein [Function unknown]; Region: COG4270 649831019059 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 649831019060 PAS fold; Region: PAS_3; pfam08447 649831019061 putative active site [active] 649831019062 heme pocket [chemical binding]; other site 649831019063 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 649831019064 dimer interface [polypeptide binding]; other site 649831019065 putative CheW interface [polypeptide binding]; other site 649831019066 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 649831019067 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 649831019068 substrate binding site [chemical binding]; other site 649831019069 dimer interface [polypeptide binding]; other site 649831019070 ATP binding site [chemical binding]; other site 649831019071 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 649831019072 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 649831019073 Walker A/P-loop; other site 649831019074 ATP binding site [chemical binding]; other site 649831019075 ABC transporter signature motif; other site 649831019076 Walker B; other site 649831019077 D-loop; other site 649831019078 H-loop/switch region; other site 649831019079 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 649831019080 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 649831019081 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 649831019082 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 649831019083 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 649831019084 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 649831019085 metal-binding site [ion binding] 649831019086 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 649831019087 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831019088 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 649831019089 Serine hydrolase; Region: Ser_hydrolase; cl17834 649831019090 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 649831019091 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831019092 putative substrate translocation pore; other site 649831019093 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 649831019094 dimerization interface [polypeptide binding]; other site 649831019095 putative DNA binding site [nucleotide binding]; other site 649831019096 putative Zn2+ binding site [ion binding]; other site 649831019097 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 649831019098 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 649831019099 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 649831019100 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 649831019101 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 649831019102 Arginase-like amidino hydrolase family; Region: Arginase-like_1; cd09999 649831019103 active site 649831019104 Mn binding site [ion binding]; other site 649831019105 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 649831019106 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 649831019107 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 649831019108 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 649831019109 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 649831019110 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 649831019111 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 649831019112 metal binding site [ion binding]; metal-binding site 649831019113 active site 649831019114 I-site; other site 649831019115 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 649831019116 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 649831019117 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 649831019118 metal binding site [ion binding]; metal-binding site 649831019119 active site 649831019120 I-site; other site 649831019121 ArgK protein; Region: ArgK; pfam03308 649831019122 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 649831019123 Walker A; other site 649831019124 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 649831019125 Switch II region; other site 649831019126 G4 box; other site 649831019127 G5 box; other site 649831019128 putative acyltransferase; Provisional; Region: PRK05790 649831019129 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 649831019130 dimer interface [polypeptide binding]; other site 649831019131 active site 649831019132 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 649831019133 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 649831019134 dimer interface [polypeptide binding]; other site 649831019135 substrate binding site [chemical binding]; other site 649831019136 metal binding site [ion binding]; metal-binding site 649831019137 DivIVA domain; Region: DivI1A_domain; TIGR03544 649831019138 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 649831019139 Domain of unknown function DUF20; Region: UPF0118; pfam01594 649831019140 heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189 649831019141 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649831019142 Walker A/P-loop; other site 649831019143 ATP binding site [chemical binding]; other site 649831019144 Q-loop/lid; other site 649831019145 ABC transporter signature motif; other site 649831019146 Walker B; other site 649831019147 D-loop; other site 649831019148 H-loop/switch region; other site 649831019149 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 649831019150 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 649831019151 NAD(P) binding site [chemical binding]; other site 649831019152 catalytic residues [active] 649831019153 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 649831019154 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 649831019155 hypothetical protein; Provisional; Region: PRK03298 649831019156 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 649831019157 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 649831019158 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 649831019159 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 649831019160 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 649831019161 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 649831019162 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 649831019163 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 649831019164 hinge; other site 649831019165 active site 649831019166 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 649831019167 short chain dehydrogenase; Provisional; Region: PRK06197 649831019168 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831019169 NAD(P) binding site [chemical binding]; other site 649831019170 active site 649831019171 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 649831019172 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 649831019173 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 649831019174 gamma subunit interface [polypeptide binding]; other site 649831019175 epsilon subunit interface [polypeptide binding]; other site 649831019176 LBP interface [polypeptide binding]; other site 649831019177 Transcriptional regulator [Transcription]; Region: LytR; COG1316 649831019178 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 649831019179 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 649831019180 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 649831019181 alpha subunit interaction interface [polypeptide binding]; other site 649831019182 Walker A motif; other site 649831019183 ATP binding site [chemical binding]; other site 649831019184 Walker B motif; other site 649831019185 inhibitor binding site; inhibition site 649831019186 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 649831019187 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 649831019188 core domain interface [polypeptide binding]; other site 649831019189 delta subunit interface [polypeptide binding]; other site 649831019190 epsilon subunit interface [polypeptide binding]; other site 649831019191 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 649831019192 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 649831019193 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 649831019194 beta subunit interaction interface [polypeptide binding]; other site 649831019195 Walker A motif; other site 649831019196 ATP binding site [chemical binding]; other site 649831019197 Walker B motif; other site 649831019198 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 649831019199 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 649831019200 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 649831019201 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 649831019202 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 649831019203 ATP synthase subunit C; Region: ATP-synt_C; cl00466 649831019204 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 649831019205 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 649831019206 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754 649831019207 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 649831019208 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 649831019209 dimer interface [polypeptide binding]; other site 649831019210 active site 649831019211 glycine-pyridoxal phosphate binding site [chemical binding]; other site 649831019212 folate binding site [chemical binding]; other site 649831019213 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 649831019214 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 649831019215 putative NAD(P) binding site [chemical binding]; other site 649831019216 putative active site [active] 649831019217 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 649831019218 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 649831019219 Low molecular weight phosphatase family; Region: LMWPc; cl00105 649831019220 active site 649831019221 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 649831019222 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 649831019223 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649831019224 S-adenosylmethionine binding site [chemical binding]; other site 649831019225 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 649831019226 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 649831019227 metal binding site [ion binding]; metal-binding site 649831019228 active site 649831019229 I-site; other site 649831019230 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 649831019231 Trp docking motif [polypeptide binding]; other site 649831019232 PQQ-like domain; Region: PQQ_2; pfam13360 649831019233 active site 649831019234 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 649831019235 Trp docking motif [polypeptide binding]; other site 649831019236 active site 649831019237 PQQ-like domain; Region: PQQ_2; pfam13360 649831019238 peptide chain release factor 1; Validated; Region: prfA; PRK00591 649831019239 This domain is found in peptide chain release factors; Region: PCRF; smart00937 649831019240 RF-1 domain; Region: RF-1; pfam00472 649831019241 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 649831019242 RNA ligase; Region: RNA_lig_T4_1; pfam09511 649831019243 polynucleotide kinase; Provisional; Region: pseT; PHA02530 649831019244 hypothetical protein; Provisional; Region: PRK06762 649831019245 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 649831019246 RNA ligase; Region: RNA_ligase; pfam09414 649831019247 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 649831019248 transcription termination factor Rho; Provisional; Region: PRK12608 649831019249 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 649831019250 RNA binding site [nucleotide binding]; other site 649831019251 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 649831019252 Walker A motif; other site 649831019253 ATP binding site [chemical binding]; other site 649831019254 Walker B motif; other site 649831019255 homoserine kinase; Provisional; Region: PRK01212 649831019256 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 649831019257 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 649831019258 Protein export membrane protein; Region: SecD_SecF; cl14618 649831019259 Transcriptional regulators [Transcription]; Region: MarR; COG1846 649831019260 MarR family; Region: MarR; pfam01047 649831019261 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 649831019262 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 649831019263 Coenzyme A binding pocket [chemical binding]; other site 649831019264 threonine synthase; Reviewed; Region: PRK06721 649831019265 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 649831019266 homodimer interface [polypeptide binding]; other site 649831019267 pyridoxal 5'-phosphate binding site [chemical binding]; other site 649831019268 catalytic residue [active] 649831019269 homoserine dehydrogenase; Provisional; Region: PRK06349 649831019270 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 649831019271 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 649831019272 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 649831019273 diaminopimelate decarboxylase; Region: lysA; TIGR01048 649831019274 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 649831019275 active site 649831019276 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 649831019277 substrate binding site [chemical binding]; other site 649831019278 catalytic residues [active] 649831019279 dimer interface [polypeptide binding]; other site 649831019280 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 649831019281 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 649831019282 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 649831019283 active site 649831019284 HIGH motif; other site 649831019285 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 649831019286 KMSK motif region; other site 649831019287 tRNA binding surface [nucleotide binding]; other site 649831019288 DALR anticodon binding domain; Region: DALR_1; smart00836 649831019289 anticodon binding site; other site 649831019290 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 649831019291 Domain of unknown function (DUF305); Region: DUF305; pfam03713 649831019292 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 649831019293 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 649831019294 Walker A/P-loop; other site 649831019295 ATP binding site [chemical binding]; other site 649831019296 Q-loop/lid; other site 649831019297 ABC transporter signature motif; other site 649831019298 Walker B; other site 649831019299 D-loop; other site 649831019300 H-loop/switch region; other site 649831019301 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 649831019302 ABC-ATPase subunit interface; other site 649831019303 dimer interface [polypeptide binding]; other site 649831019304 putative PBP binding regions; other site 649831019305 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 649831019306 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 649831019307 ABC-ATPase subunit interface; other site 649831019308 dimer interface [polypeptide binding]; other site 649831019309 putative PBP binding regions; other site 649831019310 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 649831019311 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 649831019312 siderophore binding site; other site 649831019313 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 649831019314 Catalytic domain of Protein Kinases; Region: PKc; cd00180 649831019315 active site 649831019316 ATP binding site [chemical binding]; other site 649831019317 substrate binding site [chemical binding]; other site 649831019318 activation loop (A-loop); other site 649831019319 acyl-CoA synthetase; Validated; Region: PRK06188 649831019320 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 649831019321 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 649831019322 acyl-activating enzyme (AAE) consensus motif; other site 649831019323 acyl-activating enzyme (AAE) consensus motif; other site 649831019324 AMP binding site [chemical binding]; other site 649831019325 active site 649831019326 CoA binding site [chemical binding]; other site 649831019327 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 649831019328 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 649831019329 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 649831019330 active sites [active] 649831019331 tetramer interface [polypeptide binding]; other site 649831019332 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 649831019333 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 649831019334 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 649831019335 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 649831019336 active site 649831019337 substrate binding site [chemical binding]; other site 649831019338 FMN binding site [chemical binding]; other site 649831019339 putative catalytic residues [active] 649831019340 Cytochrome P450; Region: p450; cl12078 649831019341 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 649831019342 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 649831019343 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 649831019344 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831019345 active site 649831019346 phosphorylation site [posttranslational modification] 649831019347 intermolecular recognition site; other site 649831019348 dimerization interface [polypeptide binding]; other site 649831019349 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 649831019350 DNA binding site [nucleotide binding] 649831019351 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 649831019352 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 649831019353 dimer interface [polypeptide binding]; other site 649831019354 phosphorylation site [posttranslational modification] 649831019355 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831019356 ATP binding site [chemical binding]; other site 649831019357 Mg2+ binding site [ion binding]; other site 649831019358 G-X-G motif; other site 649831019359 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 649831019360 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 649831019361 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 649831019362 dimer interface [polypeptide binding]; other site 649831019363 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 649831019364 metal binding site [ion binding]; metal-binding site 649831019365 Beta-lactamase; Region: Beta-lactamase; pfam00144 649831019366 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 649831019367 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 649831019368 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 649831019369 conserved cys residue [active] 649831019370 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 649831019371 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 649831019372 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 649831019373 active site 649831019374 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831019375 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831019376 putative substrate translocation pore; other site 649831019377 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831019378 hypothetical protein; Provisional; Region: PRK02237 649831019379 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 649831019380 anti sigma factor interaction site; other site 649831019381 regulatory phosphorylation site [posttranslational modification]; other site 649831019382 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 649831019383 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 649831019384 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 649831019385 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 649831019386 Coenzyme A binding pocket [chemical binding]; other site 649831019387 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 649831019388 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 649831019389 Moco binding site; other site 649831019390 metal coordination site [ion binding]; other site 649831019391 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 649831019392 Fasciclin domain; Region: Fasciclin; pfam02469 649831019393 Putative zinc-finger; Region: zf-HC2; pfam13490 649831019394 Anti-sigma-K factor rskA; Region: RskA; pfam10099 649831019395 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 649831019396 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 649831019397 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 649831019398 DNA binding residues [nucleotide binding] 649831019399 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 649831019400 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 649831019401 Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028 649831019402 Bulb-type mannose-specific lectin; Region: B_lectin; smart00108 649831019403 mannose binding site [chemical binding]; other site 649831019404 dimerization interface [polypeptide binding]; other site 649831019405 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 649831019406 FAD binding site [chemical binding]; other site 649831019407 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 649831019408 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 649831019409 substrate binding site [chemical binding]; other site 649831019410 ATP binding site [chemical binding]; other site 649831019411 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831019412 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 649831019413 putative substrate translocation pore; other site 649831019414 MarR family; Region: MarR_2; cl17246 649831019415 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 649831019416 succinic semialdehyde dehydrogenase; Region: PLN02278 649831019417 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 649831019418 tetramerization interface [polypeptide binding]; other site 649831019419 NAD(P) binding site [chemical binding]; other site 649831019420 catalytic residues [active] 649831019421 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 649831019422 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 649831019423 motif II; other site 649831019424 hypothetical protein; Provisional; Region: PRK08317 649831019425 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649831019426 S-adenosylmethionine binding site [chemical binding]; other site 649831019427 A-factor biosynthesis hotdog domain; Region: AfsA; pfam03756 649831019428 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 649831019429 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 649831019430 classical (c) SDRs; Region: SDR_c; cd05233 649831019431 NAD(P) binding site [chemical binding]; other site 649831019432 active site 649831019433 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 649831019434 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 649831019435 acyl-activating enzyme (AAE) consensus motif; other site 649831019436 active site 649831019437 AMP binding site [chemical binding]; other site 649831019438 CoA binding site [chemical binding]; other site 649831019439 S-adenosylmethionine synthetase; Validated; Region: PRK05250 649831019440 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 649831019441 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 649831019442 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 649831019443 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 649831019444 Histidine kinase; Region: HisKA_3; pfam07730 649831019445 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831019446 ATP binding site [chemical binding]; other site 649831019447 Mg2+ binding site [ion binding]; other site 649831019448 G-X-G motif; other site 649831019449 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649831019450 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831019451 active site 649831019452 phosphorylation site [posttranslational modification] 649831019453 intermolecular recognition site; other site 649831019454 dimerization interface [polypeptide binding]; other site 649831019455 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649831019456 DNA binding residues [nucleotide binding] 649831019457 dimerization interface [polypeptide binding]; other site 649831019458 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 649831019459 YciI-like protein; Reviewed; Region: PRK12863 649831019460 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 649831019461 FAD binding domain; Region: FAD_binding_4; pfam01565 649831019462 benzoate transport; Region: 2A0115; TIGR00895 649831019463 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831019464 putative substrate translocation pore; other site 649831019465 UbiA prenyltransferase family; Region: UbiA; pfam01040 649831019466 Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503 649831019467 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 649831019468 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831019469 NAD(P) binding site [chemical binding]; other site 649831019470 active site 649831019471 trehalose synthase; Region: treS_nterm; TIGR02456 649831019472 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 649831019473 active site 649831019474 catalytic site [active] 649831019475 Predicted transcriptional regulators [Transcription]; Region: COG1695 649831019476 Transcriptional regulator PadR-like family; Region: PadR; cl17335 649831019477 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 649831019478 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 649831019479 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 649831019480 aromatic chitin/cellulose binding site residues [chemical binding]; other site 649831019481 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 649831019482 active site 649831019483 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 649831019484 aromatic chitin/cellulose binding site residues [chemical binding]; other site 649831019485 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 649831019486 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 649831019487 putative active site [active] 649831019488 Streptomyces laminarinase-like, member of glycosyl hydrolase family 16; Region: GH16_Strep_laminarinase_like; cd02182 649831019489 active site 649831019490 catalytic residues [active] 649831019491 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 649831019492 metal binding site [ion binding]; metal-binding site 649831019493 ligand binding site [chemical binding]; other site 649831019494 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 649831019495 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 649831019496 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 649831019497 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 649831019498 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 649831019499 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 649831019500 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 649831019501 NodB motif; other site 649831019502 active site 649831019503 catalytic site [active] 649831019504 metal binding site [ion binding]; metal-binding site 649831019505 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 649831019506 putative H2TH interface [polypeptide binding]; other site 649831019507 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 649831019508 putative DNA binding site [nucleotide binding]; other site 649831019509 putative catalytic residues [active] 649831019510 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 649831019511 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 649831019512 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 649831019513 ornithine--oxo-acid transaminase; Reviewed; Region: rocD; PRK00854 649831019514 inhibitor-cofactor binding pocket; inhibition site 649831019515 pyridoxal 5'-phosphate binding site [chemical binding]; other site 649831019516 catalytic residue [active] 649831019517 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 649831019518 Amidinotransferase; Region: Amidinotransf; pfam02274 649831019519 Clp protease; Region: CLP_protease; pfam00574 649831019520 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 649831019521 oligomer interface [polypeptide binding]; other site 649831019522 active site residues [active] 649831019523 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 649831019524 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 649831019525 putative acyl-acceptor binding pocket; other site 649831019526 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 649831019527 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 649831019528 nucleophile elbow; other site 649831019529 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 649831019530 aromatic chitin/cellulose binding site residues [chemical binding]; other site 649831019531 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 649831019532 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 649831019533 putative active site [active] 649831019534 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 649831019535 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649831019536 Walker A/P-loop; other site 649831019537 ATP binding site [chemical binding]; other site 649831019538 Q-loop/lid; other site 649831019539 ABC transporter signature motif; other site 649831019540 Walker B; other site 649831019541 D-loop; other site 649831019542 H-loop/switch region; other site 649831019543 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cd05709 649831019544 Peptidase family M50; Region: Peptidase_M50; pfam02163 649831019545 active site 649831019546 putative substrate binding region [chemical binding]; other site 649831019547 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 649831019548 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 649831019549 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 649831019550 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 649831019551 dimerization interface [polypeptide binding]; other site 649831019552 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 649831019553 dimer interface [polypeptide binding]; other site 649831019554 phosphorylation site [posttranslational modification] 649831019555 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831019556 ATP binding site [chemical binding]; other site 649831019557 Mg2+ binding site [ion binding]; other site 649831019558 G-X-G motif; other site 649831019559 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 649831019560 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831019561 active site 649831019562 phosphorylation site [posttranslational modification] 649831019563 intermolecular recognition site; other site 649831019564 dimerization interface [polypeptide binding]; other site 649831019565 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 649831019566 DNA binding site [nucleotide binding] 649831019567 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 649831019568 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 649831019569 putative acyl-acceptor binding pocket; other site 649831019570 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 649831019571 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 649831019572 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 649831019573 Walker A/P-loop; other site 649831019574 ATP binding site [chemical binding]; other site 649831019575 Q-loop/lid; other site 649831019576 ABC transporter signature motif; other site 649831019577 Walker B; other site 649831019578 D-loop; other site 649831019579 H-loop/switch region; other site 649831019580 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 649831019581 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 649831019582 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 649831019583 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 649831019584 TPP-binding site [chemical binding]; other site 649831019585 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 649831019586 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 649831019587 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 649831019588 salt bridge; other site 649831019589 non-specific DNA binding site [nucleotide binding]; other site 649831019590 sequence-specific DNA binding site [nucleotide binding]; other site 649831019591 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831019592 NAD(P) binding site [chemical binding]; other site 649831019593 active site 649831019594 BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857 649831019595 DRTGG domain; Region: DRTGG; pfam07085 649831019596 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 649831019597 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 649831019598 propionate/acetate kinase; Provisional; Region: PRK12379 649831019599 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 649831019600 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 649831019601 NAD(P) binding site [chemical binding]; other site 649831019602 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 649831019603 Malic enzyme, N-terminal domain; Region: malic; pfam00390 649831019604 Malic enzyme, NAD binding domain; Region: Malic_M; smart00919 649831019605 NAD(P) binding pocket [chemical binding]; other site 649831019606 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 649831019607 Catalytic site [active] 649831019608 Nickel-containing superoxide dismutase; Region: Sod_Ni; pfam09055 649831019609 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 649831019610 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 649831019611 Coenzyme A binding pocket [chemical binding]; other site 649831019612 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 649831019613 Transcriptional regulators [Transcription]; Region: FadR; COG2186 649831019614 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 649831019615 DNA-binding site [nucleotide binding]; DNA binding site 649831019616 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 649831019617 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 649831019618 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 649831019619 Transcription factor WhiB; Region: Whib; pfam02467 649831019620 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 649831019621 putative active site [active] 649831019622 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 649831019623 active site 649831019624 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 649831019625 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 649831019626 Active Sites [active] 649831019627 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 649831019628 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 649831019629 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 649831019630 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 649831019631 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 649831019632 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 649831019633 active site 649831019634 putative catalytic site [active] 649831019635 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 649831019636 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 649831019637 Histidine kinase; Region: HisKA_2; pfam07568 649831019638 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831019639 ATP binding site [chemical binding]; other site 649831019640 Mg2+ binding site [ion binding]; other site 649831019641 G-X-G motif; other site 649831019642 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 649831019643 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 649831019644 dimer interface [polypeptide binding]; other site 649831019645 active site 649831019646 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 649831019647 dimer interface [polypeptide binding]; other site 649831019648 active site 649831019649 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 649831019650 TPR motif; other site 649831019651 TPR repeat; Region: TPR_11; pfam13414 649831019652 binding surface 649831019653 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 649831019654 carboxyltransferase (CT) interaction site; other site 649831019655 biotinylation site [posttranslational modification]; other site 649831019656 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988 649831019657 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 649831019658 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 649831019659 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 649831019660 DNA binding residues [nucleotide binding] 649831019661 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 649831019662 Transcription factor WhiB; Region: Whib; pfam02467 649831019663 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 649831019664 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 649831019665 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 649831019666 hinge; other site 649831019667 active site 649831019668 ribosome small subunit-dependent GTPase A; Region: TIGR00157 649831019669 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 649831019670 GTPase/Zn-binding domain interface [polypeptide binding]; other site 649831019671 GTP/Mg2+ binding site [chemical binding]; other site 649831019672 G4 box; other site 649831019673 G5 box; other site 649831019674 G1 box; other site 649831019675 Switch I region; other site 649831019676 G2 box; other site 649831019677 G3 box; other site 649831019678 Switch II region; other site 649831019679 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 649831019680 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 649831019681 active site 649831019682 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 649831019683 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 649831019684 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649831019685 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831019686 active site 649831019687 phosphorylation site [posttranslational modification] 649831019688 intermolecular recognition site; other site 649831019689 dimerization interface [polypeptide binding]; other site 649831019690 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649831019691 DNA binding residues [nucleotide binding] 649831019692 dimerization interface [polypeptide binding]; other site 649831019693 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 649831019694 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831019695 ATP binding site [chemical binding]; other site 649831019696 Mg2+ binding site [ion binding]; other site 649831019697 G-X-G motif; other site 649831019698 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 649831019699 active site 649831019700 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 649831019701 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 649831019702 active site 649831019703 catalytic residues [active] 649831019704 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 649831019705 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 649831019706 putative sugar binding sites [chemical binding]; other site 649831019707 Q-X-W motif; other site 649831019708 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 649831019709 sugar binding site [chemical binding]; other site 649831019710 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 649831019711 catalytic residue [active] 649831019712 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 649831019713 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 649831019714 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 649831019715 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 649831019716 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 649831019717 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 649831019718 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649831019719 S-adenosylmethionine binding site [chemical binding]; other site 649831019720 African swine fever virus J13L protein; Region: ASFV_J13L; pfam05568 649831019721 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 649831019722 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 649831019723 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 649831019724 Lamin Tail Domain; Region: LTD; pfam00932 649831019725 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 649831019726 non-specific DNA binding site [nucleotide binding]; other site 649831019727 salt bridge; other site 649831019728 sequence-specific DNA binding site [nucleotide binding]; other site 649831019729 hypothetical protein; Validated; Region: PRK00068 649831019730 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 649831019731 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 649831019732 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 649831019733 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 649831019734 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 649831019735 Protein of unknown function DUF45; Region: DUF45; pfam01863 649831019736 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 649831019737 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 649831019738 ABC1 family; Region: ABC1; cl17513 649831019739 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 649831019740 active site 649831019741 ATP binding site [chemical binding]; other site 649831019742 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 649831019743 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 649831019744 Transcription factor WhiB; Region: Whib; pfam02467 649831019745 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 649831019746 Part of AAA domain; Region: AAA_19; pfam13245 649831019747 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 649831019748 Family description; Region: UvrD_C_2; pfam13538 649831019749 HRDC domain; Region: HRDC; pfam00570 649831019750 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 649831019751 catalytic residues [active] 649831019752 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 649831019753 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 649831019754 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 649831019755 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 649831019756 putative NADH binding site [chemical binding]; other site 649831019757 putative active site [active] 649831019758 nudix motif; other site 649831019759 putative metal binding site [ion binding]; other site 649831019760 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 649831019761 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 649831019762 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 649831019763 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 649831019764 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 649831019765 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 649831019766 Rrf2 family protein; Region: rrf2_super; TIGR00738 649831019767 Transcriptional regulator; Region: Rrf2; pfam02082 649831019768 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 649831019769 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 649831019770 substrate binding pocket [chemical binding]; other site 649831019771 membrane-bound complex binding site; other site 649831019772 hinge residues; other site 649831019773 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 649831019774 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 649831019775 Walker A/P-loop; other site 649831019776 ATP binding site [chemical binding]; other site 649831019777 Q-loop/lid; other site 649831019778 ABC transporter signature motif; other site 649831019779 Walker B; other site 649831019780 D-loop; other site 649831019781 H-loop/switch region; other site 649831019782 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 649831019783 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649831019784 dimer interface [polypeptide binding]; other site 649831019785 conserved gate region; other site 649831019786 putative PBP binding loops; other site 649831019787 ABC-ATPase subunit interface; other site 649831019788 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 649831019789 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 649831019790 putative acyl-acceptor binding pocket; other site 649831019791 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 649831019792 DNA-binding site [nucleotide binding]; DNA binding site 649831019793 RNA-binding motif; other site 649831019794 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 649831019795 Part of AAA domain; Region: AAA_19; pfam13245 649831019796 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 649831019797 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 649831019798 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 649831019799 Family description; Region: UvrD_C_2; pfam13538 649831019800 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 649831019801 Transcriptional regulators [Transcription]; Region: PurR; COG1609 649831019802 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 649831019803 DNA binding site [nucleotide binding] 649831019804 domain linker motif; other site 649831019805 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 649831019806 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 649831019807 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 649831019808 putative trimer interface [polypeptide binding]; other site 649831019809 putative CoA binding site [chemical binding]; other site 649831019810 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 649831019811 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 649831019812 metal binding site [ion binding]; metal-binding site 649831019813 putative dimer interface [polypeptide binding]; other site 649831019814 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 649831019815 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 649831019816 Helix-turn-helix domain; Region: HTH_31; pfam13560 649831019817 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 649831019818 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 649831019819 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 649831019820 dimerization interface [polypeptide binding]; other site 649831019821 Lysine efflux permease [General function prediction only]; Region: COG1279 649831019822 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 649831019823 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 649831019824 DNA binding residues [nucleotide binding] 649831019825 drug binding residues [chemical binding]; other site 649831019826 dimer interface [polypeptide binding]; other site 649831019827 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cl17512 649831019828 beta-clamp/clamp loader binding surface; other site 649831019829 beta-clamp/translesion DNA polymerase binding surface; other site 649831019830 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 649831019831 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 649831019832 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 649831019833 catalytic residue [active] 649831019834 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 649831019835 anti sigma factor interaction site; other site 649831019836 regulatory phosphorylation site [posttranslational modification]; other site 649831019837 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649831019838 S-adenosylmethionine binding site [chemical binding]; other site 649831019839 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 649831019840 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 649831019841 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 649831019842 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 649831019843 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 649831019844 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 649831019845 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 649831019846 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 649831019847 catalytic triad [active] 649831019848 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 649831019849 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 649831019850 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 649831019851 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 649831019852 legume lectins; Region: lectin_L-type; cd01951 649831019853 homotetramer interaction site [polypeptide binding]; other site 649831019854 carbohydrate binding site [chemical binding]; other site 649831019855 metal binding site [ion binding]; metal-binding site 649831019856 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 649831019857 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 649831019858 active site 649831019859 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 649831019860 Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967 649831019861 putative active site [active] 649831019862 putative metal binding site [ion binding]; other site 649831019863 Fn3 associated; Region: Fn3_assoc; pfam13287 649831019864 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 649831019865 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 649831019866 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 649831019867 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831019868 NAD(P) binding site [chemical binding]; other site 649831019869 active site 649831019870 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 649831019871 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 649831019872 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 649831019873 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 649831019874 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 649831019875 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 649831019876 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 649831019877 DXD motif; other site 649831019878 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 649831019879 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 649831019880 putative trimer interface [polypeptide binding]; other site 649831019881 putative CoA binding site [chemical binding]; other site 649831019882 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 649831019883 Ligand binding site; other site 649831019884 DXD motif; other site 649831019885 Putative Catalytic site; other site 649831019886 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 649831019887 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 649831019888 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 649831019889 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 649831019890 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 649831019891 putative ADP-binding pocket [chemical binding]; other site 649831019892 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 649831019893 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 649831019894 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 649831019895 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 649831019896 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 649831019897 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 649831019898 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 649831019899 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 649831019900 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 649831019901 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 649831019902 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 649831019903 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 649831019904 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 649831019905 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 649831019906 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 649831019907 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 649831019908 O-Antigen ligase; Region: Wzy_C; pfam04932 649831019909 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 649831019910 Bacterial sugar transferase; Region: Bac_transf; pfam02397 649831019911 legume lectins; Region: lectin_L-type; cd01951 649831019912 homotetramer interaction site [polypeptide binding]; other site 649831019913 carbohydrate binding site [chemical binding]; other site 649831019914 metal binding site [ion binding]; metal-binding site 649831019915 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 649831019916 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 649831019917 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 649831019918 Domain of unknown function (DUF397); Region: DUF397; pfam04149 649831019919 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 649831019920 sequence-specific DNA binding site [nucleotide binding]; other site 649831019921 salt bridge; other site 649831019922 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 649831019923 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 649831019924 Predicted transcriptional regulators [Transcription]; Region: COG1695 649831019925 Transcriptional regulator PadR-like family; Region: PadR; cl17335 649831019926 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 649831019927 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 649831019928 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 649831019929 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 649831019930 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 649831019931 DNA binding residues [nucleotide binding] 649831019932 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 649831019933 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 649831019934 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 649831019935 active site 649831019936 catalytic tetrad [active] 649831019937 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 649831019938 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 649831019939 DivIVA protein; Region: DivIVA; pfam05103 649831019940 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cd00110 649831019941 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649831019942 S-adenosylmethionine binding site [chemical binding]; other site 649831019943 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 649831019944 active site 649831019945 catalytic residues [active] 649831019946 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 649831019947 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 649831019948 pyridoxal 5'-phosphate binding site [chemical binding]; other site 649831019949 homodimer interface [polypeptide binding]; other site 649831019950 catalytic residue [active] 649831019951 Ferredoxin [Energy production and conversion]; Region: COG1146 649831019952 4Fe-4S binding domain; Region: Fer4; pfam00037 649831019953 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 649831019954 Coenzyme A binding pocket [chemical binding]; other site 649831019955 N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445 649831019956 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 649831019957 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 649831019958 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 649831019959 putative active site [active] 649831019960 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 649831019961 putative active site [active] 649831019962 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 649831019963 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 649831019964 metal binding site [ion binding]; metal-binding site 649831019965 active site 649831019966 I-site; other site 649831019967 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 649831019968 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 649831019969 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 649831019970 L-aspartate oxidase; Provisional; Region: PRK06175 649831019971 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 649831019972 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 649831019973 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 649831019974 catalytic loop [active] 649831019975 iron binding site [ion binding]; other site 649831019976 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 649831019977 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 649831019978 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 649831019979 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 649831019980 Walker A/P-loop; other site 649831019981 ATP binding site [chemical binding]; other site 649831019982 Q-loop/lid; other site 649831019983 ABC transporter signature motif; other site 649831019984 Walker B; other site 649831019985 D-loop; other site 649831019986 H-loop/switch region; other site 649831019987 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 649831019988 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 649831019989 Walker A/P-loop; other site 649831019990 ATP binding site [chemical binding]; other site 649831019991 Q-loop/lid; other site 649831019992 ABC transporter signature motif; other site 649831019993 Walker B; other site 649831019994 D-loop; other site 649831019995 H-loop/switch region; other site 649831019996 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 649831019997 TM-ABC transporter signature motif; other site 649831019998 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 649831019999 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 649831020000 TM-ABC transporter signature motif; other site 649831020001 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 649831020002 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 649831020003 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 649831020004 classical (c) SDRs; Region: SDR_c; cd05233 649831020005 NAD(P) binding site [chemical binding]; other site 649831020006 active site 649831020007 classical (c) SDRs; Region: SDR_c; cd05233 649831020008 NAD(P) binding site [chemical binding]; other site 649831020009 active site 649831020010 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 649831020011 Phosphotransferase enzyme family; Region: APH; pfam01636 649831020012 putative active site [active] 649831020013 putative substrate binding site [chemical binding]; other site 649831020014 ATP binding site [chemical binding]; other site 649831020015 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 649831020016 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 649831020017 active site 649831020018 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831020019 malate dehydrogenase; Provisional; Region: PRK05442 649831020020 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 649831020021 NAD(P) binding site [chemical binding]; other site 649831020022 dimer interface [polypeptide binding]; other site 649831020023 malate binding site [chemical binding]; other site 649831020024 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 649831020025 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 649831020026 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 649831020027 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 649831020028 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 649831020029 putative active site [active] 649831020030 putative dimer interface [polypeptide binding]; other site 649831020031 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 649831020032 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 649831020033 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 649831020034 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 649831020035 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 649831020036 NAD binding site [chemical binding]; other site 649831020037 catalytic Zn binding site [ion binding]; other site 649831020038 substrate binding site [chemical binding]; other site 649831020039 structural Zn binding site [ion binding]; other site 649831020040 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 649831020041 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 649831020042 NAD binding site [chemical binding]; other site 649831020043 catalytic residues [active] 649831020044 tetracycline repressor protein TetR; Provisional; Region: PRK13756 649831020045 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831020046 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 649831020047 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 649831020048 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 649831020049 active site 649831020050 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 649831020051 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 649831020052 acyl-activating enzyme (AAE) consensus motif; other site 649831020053 putative AMP binding site [chemical binding]; other site 649831020054 putative active site [active] 649831020055 putative CoA binding site [chemical binding]; other site 649831020056 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 649831020057 active site 649831020058 8-oxo-dGMP binding site [chemical binding]; other site 649831020059 nudix motif; other site 649831020060 metal binding site [ion binding]; metal-binding site 649831020061 Pleckstrin homology-like domain; Region: PH-like; cl17171 649831020062 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 649831020063 active site pocket [active] 649831020064 oxyanion hole [active] 649831020065 catalytic triad [active] 649831020066 active site nucleophile [active] 649831020067 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 649831020068 active site 649831020069 NTP binding site [chemical binding]; other site 649831020070 metal binding triad [ion binding]; metal-binding site 649831020071 Methyltransferase domain; Region: Methyltransf_11; pfam08241 649831020072 S-adenosylmethionine binding site [chemical binding]; other site 649831020073 G5 domain; Region: G5; pfam07501 649831020074 Lamin Tail Domain; Region: LTD; pfam00932 649831020075 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 649831020076 Predicted flavoprotein [General function prediction only]; Region: COG0431 649831020077 Transcriptional regulators [Transcription]; Region: MarR; COG1846 649831020078 MarR family; Region: MarR_2; pfam12802 649831020079 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 649831020080 dimerization interface [polypeptide binding]; other site 649831020081 putative DNA binding site [nucleotide binding]; other site 649831020082 putative Zn2+ binding site [ion binding]; other site 649831020083 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 649831020084 hydrophobic ligand binding site; other site 649831020085 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 649831020086 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 649831020087 catalytic residues [active] 649831020088 catalytic nucleophile [active] 649831020089 Recombinase; Region: Recombinase; pfam07508 649831020090 Domain of unknown function (DUF3854); Region: DUF3854; pfam12965 649831020091 D5 N terminal like; Region: D5_N; pfam08706 649831020092 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 649831020093 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 649831020094 non-specific DNA binding site [nucleotide binding]; other site 649831020095 salt bridge; other site 649831020096 sequence-specific DNA binding site [nucleotide binding]; other site 649831020097 GTP-binding protein YchF; Reviewed; Region: PRK09601 649831020098 YchF GTPase; Region: YchF; cd01900 649831020099 G1 box; other site 649831020100 GTP/Mg2+ binding site [chemical binding]; other site 649831020101 Switch I region; other site 649831020102 G2 box; other site 649831020103 Switch II region; other site 649831020104 G3 box; other site 649831020105 G4 box; other site 649831020106 G5 box; other site 649831020107 Protein of unknown function (DUF933); Region: YchF-GTPase_C; pfam06071 649831020108 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 649831020109 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 649831020110 non-specific DNA binding site [nucleotide binding]; other site 649831020111 salt bridge; other site 649831020112 sequence-specific DNA binding site [nucleotide binding]; other site 649831020113 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 649831020114 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 649831020115 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 649831020116 AlkA N-terminal domain; Region: AlkA_N; pfam06029 649831020117 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 649831020118 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 649831020119 minor groove reading motif; other site 649831020120 helix-hairpin-helix signature motif; other site 649831020121 substrate binding pocket [chemical binding]; other site 649831020122 active site 649831020123 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 649831020124 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 649831020125 active site 649831020126 DNA binding site [nucleotide binding] 649831020127 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 649831020128 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 649831020129 active site 649831020130 HIGH motif; other site 649831020131 nucleotide binding site [chemical binding]; other site 649831020132 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 649831020133 active site 649831020134 KMSKS motif; other site 649831020135 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 649831020136 tRNA binding surface [nucleotide binding]; other site 649831020137 anticodon binding site; other site 649831020138 Protein of unknown function, DUF606; Region: DUF606; pfam04657 649831020139 Protein of unknown function, DUF606; Region: DUF606; pfam04657 649831020140 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 649831020141 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 649831020142 putative active site [active] 649831020143 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 649831020144 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 649831020145 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 649831020146 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 649831020147 generic binding surface II; other site 649831020148 generic binding surface I; other site 649831020149 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 649831020150 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 649831020151 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 649831020152 hypothetical protein; Provisional; Region: PRK07236 649831020153 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 649831020154 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831020155 NADH(P)-binding; Region: NAD_binding_10; pfam13460 649831020156 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831020157 NAD(P) binding site [chemical binding]; other site 649831020158 short chain dehydrogenase; Provisional; Region: PRK06197 649831020159 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 649831020160 putative NAD(P) binding site [chemical binding]; other site 649831020161 active site 649831020162 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 649831020163 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831020164 WHG domain; Region: WHG; pfam13305 649831020165 RmuC family; Region: RmuC; pfam02646 649831020166 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 649831020167 cleavage site 649831020168 active site 649831020169 substrate binding sites [chemical binding]; other site 649831020170 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 649831020171 N-acetyl-D-glucosamine binding site [chemical binding]; other site 649831020172 catalytic residue [active] 649831020173 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 649831020174 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 649831020175 putative active site [active] 649831020176 PhoH-like protein; Region: PhoH; pfam02562 649831020177 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 649831020178 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 649831020179 active site 649831020180 motif I; other site 649831020181 motif II; other site 649831020182 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 649831020183 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 649831020184 catalytic residue [active] 649831020185 putative FPP diphosphate binding site; other site 649831020186 putative FPP binding hydrophobic cleft; other site 649831020187 dimer interface [polypeptide binding]; other site 649831020188 putative IPP diphosphate binding site; other site 649831020189 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 649831020190 hypothetical protein; Provisional; Region: PRK07236 649831020191 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 649831020192 active site 649831020193 substrate-binding site [chemical binding]; other site 649831020194 metal-binding site [ion binding] 649831020195 GTP binding site [chemical binding]; other site 649831020196 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 649831020197 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 649831020198 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 649831020199 DNA binding residues [nucleotide binding] 649831020200 Predicted membrane protein [Function unknown]; Region: COG2246 649831020201 GtrA-like protein; Region: GtrA; pfam04138 649831020202 Predicted membrane protein [Function unknown]; Region: COG2246 649831020203 GtrA-like protein; Region: GtrA; pfam04138 649831020204 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 649831020205 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 649831020206 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 649831020207 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 649831020208 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 649831020209 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 649831020210 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 649831020211 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 649831020212 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 649831020213 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 649831020214 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 649831020215 Catalytic domain of Protein Kinases; Region: PKc; cd00180 649831020216 active site 649831020217 ATP binding site [chemical binding]; other site 649831020218 substrate binding site [chemical binding]; other site 649831020219 activation loop (A-loop); other site 649831020220 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 649831020221 ABC-2 type transporter; Region: ABC2_membrane; cl17235 649831020222 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649831020223 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 649831020224 Walker A/P-loop; other site 649831020225 ATP binding site [chemical binding]; other site 649831020226 Q-loop/lid; other site 649831020227 ABC transporter signature motif; other site 649831020228 Walker B; other site 649831020229 D-loop; other site 649831020230 H-loop/switch region; other site 649831020231 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 649831020232 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 649831020233 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 649831020234 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 649831020235 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 649831020236 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 649831020237 carboxyltransferase (CT) interaction site; other site 649831020238 biotinylation site [posttranslational modification]; other site 649831020239 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 649831020240 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 649831020241 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 649831020242 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 649831020243 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 649831020244 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 649831020245 dimerization interface [polypeptide binding]; other site 649831020246 putative catalytic residue [active] 649831020247 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 649831020248 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 649831020249 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 649831020250 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 649831020251 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 649831020252 metal binding site [ion binding]; metal-binding site 649831020253 putative dimer interface [polypeptide binding]; other site 649831020254 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 649831020255 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 649831020256 Catalytic domain of Protein Kinases; Region: PKc; cd00180 649831020257 active site 649831020258 ATP binding site [chemical binding]; other site 649831020259 substrate binding site [chemical binding]; other site 649831020260 activation loop (A-loop); other site 649831020261 PsbP; Region: PsbP; cl03356 649831020262 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 649831020263 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 649831020264 active site 649831020265 substrate binding site [chemical binding]; other site 649831020266 metal binding site [ion binding]; metal-binding site 649831020267 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 649831020268 Domain of unknown function (DUF1792); Region: DUF1792; cl07392 649831020269 putative glycosyl transferase; Provisional; Region: PRK10073 649831020270 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 649831020271 active site 649831020272 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 649831020273 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 649831020274 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 649831020275 putative active site [active] 649831020276 nucleotide binding site [chemical binding]; other site 649831020277 nudix motif; other site 649831020278 putative metal binding site [ion binding]; other site 649831020279 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 649831020280 active site 649831020281 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 649831020282 intersubunit interface [polypeptide binding]; other site 649831020283 active site 649831020284 catalytic residue [active] 649831020285 Aldehyde dehydrogenase family 16A1-like; Region: ALDH_F16; cd07111 649831020286 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 649831020287 NAD(P) binding site [chemical binding]; other site 649831020288 catalytic residues [active] 649831020289 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 649831020290 NAD(P) binding site [chemical binding]; other site 649831020291 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 649831020292 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 649831020293 Coenzyme A binding pocket [chemical binding]; other site 649831020294 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 649831020295 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 649831020296 Coenzyme A binding pocket [chemical binding]; other site 649831020297 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 649831020298 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 649831020299 G1 box; other site 649831020300 GTP/Mg2+ binding site [chemical binding]; other site 649831020301 G2 box; other site 649831020302 Switch I region; other site 649831020303 G3 box; other site 649831020304 Switch II region; other site 649831020305 G4 box; other site 649831020306 G5 box; other site 649831020307 Protein of unknown function (DUF742); Region: DUF742; pfam05331 649831020308 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 649831020309 Nitrate and nitrite sensing; Region: NIT; pfam08376 649831020310 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 649831020311 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831020312 ATP binding site [chemical binding]; other site 649831020313 Mg2+ binding site [ion binding]; other site 649831020314 G-X-G motif; other site 649831020315 adenosine deaminase; Provisional; Region: PRK09358 649831020316 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 649831020317 active site 649831020318 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 649831020319 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 649831020320 Domain of unknown function (DUF4272); Region: DUF4272; pfam14094 649831020321 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 649831020322 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 649831020323 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 649831020324 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 649831020325 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 649831020326 active site 649831020327 catalytic motif [active] 649831020328 Zn binding site [ion binding]; other site 649831020329 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 649831020330 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 649831020331 TM-ABC transporter signature motif; other site 649831020332 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 649831020333 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 649831020334 TM-ABC transporter signature motif; other site 649831020335 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 649831020336 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 649831020337 Walker A/P-loop; other site 649831020338 ATP binding site [chemical binding]; other site 649831020339 Q-loop/lid; other site 649831020340 ABC transporter signature motif; other site 649831020341 Walker B; other site 649831020342 D-loop; other site 649831020343 H-loop/switch region; other site 649831020344 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 649831020345 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 649831020346 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 649831020347 ligand binding site [chemical binding]; other site 649831020348 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 649831020349 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831020350 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 649831020351 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 649831020352 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 649831020353 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 649831020354 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 649831020355 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 649831020356 active site 649831020357 HIGH motif; other site 649831020358 dimer interface [polypeptide binding]; other site 649831020359 KMSKS motif; other site 649831020360 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 649831020361 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 649831020362 NAD binding site [chemical binding]; other site 649831020363 homodimer interface [polypeptide binding]; other site 649831020364 active site 649831020365 substrate binding site [chemical binding]; other site 649831020366 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 649831020367 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 649831020368 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 649831020369 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 649831020370 CysD dimerization site [polypeptide binding]; other site 649831020371 G1 box; other site 649831020372 putative GEF interaction site [polypeptide binding]; other site 649831020373 GTP/Mg2+ binding site [chemical binding]; other site 649831020374 Switch I region; other site 649831020375 G2 box; other site 649831020376 G3 box; other site 649831020377 Switch II region; other site 649831020378 G4 box; other site 649831020379 G5 box; other site 649831020380 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 649831020381 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 649831020382 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 649831020383 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 649831020384 Active Sites [active] 649831020385 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 649831020386 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 649831020387 active site 649831020388 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 649831020389 Bacterial sugar transferase; Region: Bac_transf; pfam02397 649831020390 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 649831020391 putative active site [active] 649831020392 catalytic residue [active] 649831020393 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 649831020394 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 649831020395 5S rRNA interface [nucleotide binding]; other site 649831020396 CTC domain interface [polypeptide binding]; other site 649831020397 L16 interface [polypeptide binding]; other site 649831020398 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 649831020399 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 649831020400 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 649831020401 active site 649831020402 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 649831020403 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 649831020404 Substrate binding site; other site 649831020405 Mg++ binding site; other site 649831020406 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 649831020407 active site 649831020408 substrate binding site [chemical binding]; other site 649831020409 CoA binding site [chemical binding]; other site 649831020410 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 649831020411 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 649831020412 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 649831020413 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 649831020414 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 649831020415 catalytic site [active] 649831020416 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 649831020417 Beta-ketoacyl synthase, N-terminal domain; Region: ketoacyl-synt; pfam00109 649831020418 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831020419 active site 649831020420 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 649831020421 Acyl transferase domain; Region: Acyl_transf_1; cl08282 649831020422 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 649831020423 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 649831020424 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 649831020425 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 649831020426 phosphate binding site [ion binding]; other site 649831020427 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 649831020428 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 649831020429 active site 649831020430 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 649831020431 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 649831020432 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 649831020433 putative NADP binding site [chemical binding]; other site 649831020434 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 649831020435 active site 649831020436 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 649831020437 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831020438 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 649831020439 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 649831020440 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 649831020441 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 649831020442 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 649831020443 putative active site [active] 649831020444 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 649831020445 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 649831020446 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 649831020447 active site 649831020448 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 649831020449 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 649831020450 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 649831020451 active site 649831020452 KMSKS motif; other site 649831020453 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 649831020454 tRNA binding surface [nucleotide binding]; other site 649831020455 anticodon binding site; other site 649831020456 Predicted methyltransferases [General function prediction only]; Region: COG0313 649831020457 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 649831020458 putative SAM binding site [chemical binding]; other site 649831020459 putative homodimer interface [polypeptide binding]; other site 649831020460 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 649831020461 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 649831020462 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 649831020463 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 649831020464 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 649831020465 DXD motif; other site 649831020466 GAF domain; Region: GAF; pfam01590 649831020467 GAF domain; Region: GAF_2; pfam13185 649831020468 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 649831020469 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831020470 ATP binding site [chemical binding]; other site 649831020471 Mg2+ binding site [ion binding]; other site 649831020472 G-X-G motif; other site 649831020473 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 649831020474 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 649831020475 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 649831020476 active site 649831020477 metal binding site [ion binding]; metal-binding site 649831020478 hexamer interface [polypeptide binding]; other site 649831020479 Response regulator receiver domain; Region: Response_reg; pfam00072 649831020480 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831020481 active site 649831020482 phosphorylation site [posttranslational modification] 649831020483 intermolecular recognition site; other site 649831020484 dimerization interface [polypeptide binding]; other site 649831020485 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 649831020486 active site 649831020487 Predicted integral membrane proteins containing uncharacterized repeats [Function unknown]; Region: COG5563 649831020488 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 649831020489 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 649831020490 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 649831020491 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 649831020492 dimer interface [polypeptide binding]; other site 649831020493 putative functional site; other site 649831020494 putative MPT binding site; other site 649831020495 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 649831020496 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 649831020497 active site 649831020498 tetramer interface; other site 649831020499 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 649831020500 dimerization interface [polypeptide binding]; other site 649831020501 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 649831020502 GAF domain; Region: GAF; pfam01590 649831020503 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 649831020504 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 649831020505 metal binding site [ion binding]; metal-binding site 649831020506 active site 649831020507 I-site; other site 649831020508 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 649831020509 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 649831020510 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 649831020511 metal binding site 2 [ion binding]; metal-binding site 649831020512 putative DNA binding helix; other site 649831020513 metal binding site 1 [ion binding]; metal-binding site 649831020514 dimer interface [polypeptide binding]; other site 649831020515 structural Zn2+ binding site [ion binding]; other site 649831020516 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 649831020517 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 649831020518 Homeodomain-like domain; Region: HTH_23; cl17451 649831020519 Winged helix-turn helix; Region: HTH_29; pfam13551 649831020520 Integrase core domain; Region: rve; pfam00665 649831020521 Integrase core domain; Region: rve_3; pfam13683 649831020522 MarC family integral membrane protein; Region: MarC; cl00919 649831020523 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 649831020524 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 649831020525 active site 649831020526 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 649831020527 Bacterial PH domain; Region: DUF304; pfam03703 649831020528 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 649831020529 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 649831020530 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 649831020531 catalytic residues [active] 649831020532 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 649831020533 protein-splicing catalytic site; other site 649831020534 thioester formation/cholesterol transfer; other site 649831020535 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 649831020536 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 649831020537 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 649831020538 FeS/SAM binding site; other site 649831020539 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 649831020540 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 649831020541 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 649831020542 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831020543 NAD(P) binding site [chemical binding]; other site 649831020544 active site 649831020545 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 649831020546 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 649831020547 motif II; other site 649831020548 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 649831020549 MgtE intracellular N domain; Region: MgtE_N; smart00924 649831020550 FOG: CBS domain [General function prediction only]; Region: COG0517 649831020551 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 649831020552 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 649831020553 Domain of unknown function DUF59; Region: DUF59; pfam01883 649831020554 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 649831020555 sec-independent translocase; Provisional; Region: PRK01371 649831020556 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 649831020557 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 649831020558 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 649831020559 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 649831020560 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649831020561 S-adenosylmethionine binding site [chemical binding]; other site 649831020562 multifunctional aminopeptidase A; Provisional; Region: PRK00913 649831020563 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 649831020564 interface (dimer of trimers) [polypeptide binding]; other site 649831020565 Substrate-binding/catalytic site; other site 649831020566 Zn-binding sites [ion binding]; other site 649831020567 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 649831020568 PaaX-like protein; Region: PaaX; pfam07848 649831020569 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 649831020570 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 649831020571 enoyl-CoA hydratase; Provisional; Region: PRK06688 649831020572 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 649831020573 substrate binding site [chemical binding]; other site 649831020574 oxyanion hole (OAH) forming residues; other site 649831020575 trimer interface [polypeptide binding]; other site 649831020576 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 649831020577 cleavage site 649831020578 active site 649831020579 substrate binding sites [chemical binding]; other site 649831020580 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 649831020581 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 649831020582 hydrophobic ligand binding site; other site 649831020583 DivIVA domain; Region: DivI1A_domain; TIGR03544 649831020584 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 649831020585 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 649831020586 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 649831020587 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 649831020588 dimer interface [polypeptide binding]; other site 649831020589 PYR/PP interface [polypeptide binding]; other site 649831020590 TPP binding site [chemical binding]; other site 649831020591 substrate binding site [chemical binding]; other site 649831020592 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 649831020593 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 649831020594 TPP-binding site [chemical binding]; other site 649831020595 Ion channel; Region: Ion_trans_2; pfam07885 649831020596 TrkA-N domain; Region: TrkA_N; pfam02254 649831020597 Prokaryotic phospholipase A2; Region: Phospholip_A2_3; pfam09056 649831020598 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 649831020599 cyclase homology domain; Region: CHD; cd07302 649831020600 nucleotidyl binding site; other site 649831020601 metal binding site [ion binding]; metal-binding site 649831020602 dimer interface [polypeptide binding]; other site 649831020603 Predicted ATPase [General function prediction only]; Region: COG3903 649831020604 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 649831020605 N-acetyl-D-glucosamine binding site [chemical binding]; other site 649831020606 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 649831020607 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 649831020608 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 649831020609 dimer interface [polypeptide binding]; other site 649831020610 active site 649831020611 Schiff base residues; other site 649831020612 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 649831020613 homodimer interface [polypeptide binding]; other site 649831020614 active site 649831020615 SAM binding site [chemical binding]; other site 649831020616 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 649831020617 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 649831020618 active site 649831020619 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 649831020620 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 649831020621 domain interfaces; other site 649831020622 active site 649831020623 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 649831020624 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 649831020625 tRNA; other site 649831020626 putative tRNA binding site [nucleotide binding]; other site 649831020627 putative NADP binding site [chemical binding]; other site 649831020628 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 649831020629 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 649831020630 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 649831020631 CoA binding domain; Region: CoA_binding; smart00881 649831020632 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 649831020633 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 649831020634 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 649831020635 acyl-activating enzyme (AAE) consensus motif; other site 649831020636 AMP binding site [chemical binding]; other site 649831020637 active site 649831020638 CoA binding site [chemical binding]; other site 649831020639 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 649831020640 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 649831020641 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 649831020642 DNA binding residues [nucleotide binding] 649831020643 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 649831020644 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 649831020645 putative acyl-acceptor binding pocket; other site 649831020646 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831020647 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 649831020648 NAD(P) binding site [chemical binding]; other site 649831020649 active site 649831020650 DNA binding domain, excisionase family; Region: excise; TIGR01764 649831020651 Proline dehydrogenase; Region: Pro_dh; cl03282 649831020652 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 649831020653 CGNR zinc finger; Region: zf-CGNR; pfam11706 649831020654 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 649831020655 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 649831020656 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 649831020657 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831020658 active site 649831020659 phosphorylation site [posttranslational modification] 649831020660 intermolecular recognition site; other site 649831020661 dimerization interface [polypeptide binding]; other site 649831020662 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 649831020663 DNA binding site [nucleotide binding] 649831020664 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 649831020665 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 649831020666 dimer interface [polypeptide binding]; other site 649831020667 phosphorylation site [posttranslational modification] 649831020668 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831020669 ATP binding site [chemical binding]; other site 649831020670 Mg2+ binding site [ion binding]; other site 649831020671 G-X-G motif; other site 649831020672 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 649831020673 PhoU domain; Region: PhoU; pfam01895 649831020674 PhoU domain; Region: PhoU; pfam01895 649831020675 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 649831020676 catalytic core [active] 649831020677 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831020678 Major Facilitator Superfamily; Region: MFS_1; pfam07690 649831020679 putative substrate translocation pore; other site 649831020680 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 649831020681 CheW-like domain; Region: CheW; pfam01584 649831020682 CheW-like domain; Region: CheW; pfam01584 649831020683 PAS domain; Region: PAS_9; pfam13426 649831020684 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 649831020685 PAS domain; Region: PAS_9; pfam13426 649831020686 putative active site [active] 649831020687 heme pocket [chemical binding]; other site 649831020688 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 649831020689 PAS domain; Region: PAS_9; pfam13426 649831020690 putative active site [active] 649831020691 heme pocket [chemical binding]; other site 649831020692 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 649831020693 PAS domain; Region: PAS_9; pfam13426 649831020694 putative active site [active] 649831020695 heme pocket [chemical binding]; other site 649831020696 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 649831020697 PAS domain; Region: PAS_9; pfam13426 649831020698 putative active site [active] 649831020699 heme pocket [chemical binding]; other site 649831020700 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 649831020701 PAS domain; Region: PAS_9; pfam13426 649831020702 putative active site [active] 649831020703 heme pocket [chemical binding]; other site 649831020704 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 649831020705 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 649831020706 dimer interface [polypeptide binding]; other site 649831020707 putative CheW interface [polypeptide binding]; other site 649831020708 Predicted archaeal kinase (sugar kinase superfamily) [General function prediction only]; Region: COG1829 649831020709 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831020710 Major Facilitator Superfamily; Region: MFS_1; pfam07690 649831020711 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 649831020712 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 649831020713 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 649831020714 putative ADP-binding pocket [chemical binding]; other site 649831020715 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831020716 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 649831020717 NAD(P) binding site [chemical binding]; other site 649831020718 active site 649831020719 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831020720 active site 649831020721 phosphorylation site [posttranslational modification] 649831020722 intermolecular recognition site; other site 649831020723 dimerization interface [polypeptide binding]; other site 649831020724 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 649831020725 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 649831020726 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 649831020727 calcium binding site 2 [ion binding]; other site 649831020728 active site 649831020729 catalytic triad [active] 649831020730 calcium binding site 1 [ion binding]; other site 649831020731 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 649831020732 PAS domain; Region: PAS_8; pfam13188 649831020733 PAS domain; Region: PAS_9; pfam13426 649831020734 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 649831020735 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 649831020736 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 649831020737 dimer interface [polypeptide binding]; other site 649831020738 phosphorylation site [posttranslational modification] 649831020739 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831020740 ATP binding site [chemical binding]; other site 649831020741 Mg2+ binding site [ion binding]; other site 649831020742 G-X-G motif; other site 649831020743 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 649831020744 putative hydrophobic ligand binding site [chemical binding]; other site 649831020745 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 649831020746 active site 649831020747 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 649831020748 dimerization interface [polypeptide binding]; other site 649831020749 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 649831020750 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 649831020751 dimer interface [polypeptide binding]; other site 649831020752 putative CheW interface [polypeptide binding]; other site 649831020753 Bacterial SH3 domain; Region: SH3_3; cl17532 649831020754 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 649831020755 Peptidase family M23; Region: Peptidase_M23; pfam01551 649831020756 Global regulator protein family; Region: CsrA; pfam02599 649831020757 FliW protein; Region: FliW; pfam02623 649831020758 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 649831020759 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 649831020760 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 649831020761 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 649831020762 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 649831020763 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 649831020764 flagellin; Reviewed; Region: PRK08869 649831020765 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 649831020766 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 649831020767 Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345 649831020768 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 649831020769 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 649831020770 Flagellar protein FliS; Region: FliS; cl00654 649831020771 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 649831020772 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 649831020773 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 649831020774 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 649831020775 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 649831020776 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 649831020777 Domain of unknown function (DUF4381); Region: DUF4381; pfam14316 649831020778 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 649831020779 FliG C-terminal domain; Region: FliG_C; pfam01706 649831020780 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 649831020781 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 649831020782 Walker A motif/ATP binding site; other site 649831020783 Walker B motif; other site 649831020784 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831020785 NADH(P)-binding; Region: NAD_binding_10; pfam13460 649831020786 NAD(P) binding site [chemical binding]; other site 649831020787 active site 649831020788 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 649831020789 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 649831020790 active site 649831020791 Transcriptional regulator [Transcription]; Region: LysR; COG0583 649831020792 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 649831020793 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 649831020794 putative substrate binding pocket [chemical binding]; other site 649831020795 putative dimerization interface [polypeptide binding]; other site 649831020796 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 649831020797 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 649831020798 NlpC/P60 family; Region: NLPC_P60; pfam00877 649831020799 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 649831020800 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 649831020801 N-acetyl-D-glucosamine binding site [chemical binding]; other site 649831020802 catalytic residue [active] 649831020803 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 649831020804 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 649831020805 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 649831020806 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 649831020807 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 649831020808 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 649831020809 Flagellar protein (FlbD); Region: FlbD; pfam06289 649831020810 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 649831020811 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 649831020812 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 649831020813 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 649831020814 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 649831020815 ligand binding site [chemical binding]; other site 649831020816 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 649831020817 Flagellar motor switch protein FliM; Region: FliM; pfam02154 649831020818 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 649831020819 flagellar motor switch protein FliN; Region: fliN; TIGR02480 649831020820 flagellar biosynthetic protein FliO; Region: FliO_TIGR; TIGR03500 649831020821 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 649831020822 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 649831020823 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 649831020824 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 649831020825 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 649831020826 FHIPEP family; Region: FHIPEP; pfam00771 649831020827 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 649831020828 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 649831020829 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831020830 active site 649831020831 phosphorylation site [posttranslational modification] 649831020832 intermolecular recognition site; other site 649831020833 dimerization interface [polypeptide binding]; other site 649831020834 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 649831020835 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831020836 Response regulator receiver domain; Region: Response_reg; pfam00072 649831020837 active site 649831020838 phosphorylation site [posttranslational modification] 649831020839 intermolecular recognition site; other site 649831020840 dimerization interface [polypeptide binding]; other site 649831020841 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 649831020842 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 649831020843 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649831020844 S-adenosylmethionine binding site [chemical binding]; other site 649831020845 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 649831020846 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831020847 active site 649831020848 phosphorylation site [posttranslational modification] 649831020849 intermolecular recognition site; other site 649831020850 dimerization interface [polypeptide binding]; other site 649831020851 CheB methylesterase; Region: CheB_methylest; pfam01339 649831020852 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 649831020853 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 649831020854 putative binding surface; other site 649831020855 active site 649831020856 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 649831020857 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 649831020858 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831020859 ATP binding site [chemical binding]; other site 649831020860 Mg2+ binding site [ion binding]; other site 649831020861 G-X-G motif; other site 649831020862 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 649831020863 CheW-like domain; Region: CheW; pfam01584 649831020864 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 649831020865 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831020866 active site 649831020867 phosphorylation site [posttranslational modification] 649831020868 intermolecular recognition site; other site 649831020869 dimerization interface [polypeptide binding]; other site 649831020870 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 649831020871 DNA binding site [nucleotide binding] 649831020872 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 649831020873 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 649831020874 dimer interface [polypeptide binding]; other site 649831020875 phosphorylation site [posttranslational modification] 649831020876 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 649831020877 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 649831020878 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 649831020879 FAD binding domain; Region: FAD_binding_4; pfam01565 649831020880 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 649831020881 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 649831020882 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 649831020883 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 649831020884 beta-galactosidase; Region: BGL; TIGR03356 649831020885 Transcriptional regulators [Transcription]; Region: PurR; COG1609 649831020886 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 649831020887 DNA binding site [nucleotide binding] 649831020888 domain linker motif; other site 649831020889 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 649831020890 putative dimerization interface [polypeptide binding]; other site 649831020891 putative ligand binding site [chemical binding]; other site 649831020892 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 649831020893 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 649831020894 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 649831020895 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 649831020896 non-specific DNA binding site [nucleotide binding]; other site 649831020897 salt bridge; other site 649831020898 sequence-specific DNA binding site [nucleotide binding]; other site 649831020899 L-asparaginase II; Region: Asparaginase_II; pfam06089 649831020900 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 649831020901 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 649831020902 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 649831020903 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 649831020904 ferric uptake regulator; Provisional; Region: fur; PRK09462 649831020905 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 649831020906 metal binding site 2 [ion binding]; metal-binding site 649831020907 putative DNA binding helix; other site 649831020908 metal binding site 1 [ion binding]; metal-binding site 649831020909 dimer interface [polypeptide binding]; other site 649831020910 structural Zn2+ binding site [ion binding]; other site 649831020911 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 649831020912 heme-binding site [chemical binding]; other site 649831020913 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 649831020914 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 649831020915 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 649831020916 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 649831020917 active site residue [active] 649831020918 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 649831020919 active site residue [active] 649831020920 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 649831020921 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 649831020922 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 649831020923 DNA binding site [nucleotide binding] 649831020924 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 649831020925 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 649831020926 Coenzyme A binding pocket [chemical binding]; other site 649831020927 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 649831020928 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 649831020929 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 649831020930 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 649831020931 putative DNA binding site [nucleotide binding]; other site 649831020932 putative Zn2+ binding site [ion binding]; other site 649831020933 AsnC family; Region: AsnC_trans_reg; pfam01037 649831020934 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831020935 Major Facilitator Superfamily; Region: MFS_1; pfam07690 649831020936 putative substrate translocation pore; other site 649831020937 MarR family; Region: MarR; pfam01047 649831020938 PBP superfamily domain; Region: PBP_like_2; cl17296 649831020939 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 649831020940 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649831020941 dimer interface [polypeptide binding]; other site 649831020942 conserved gate region; other site 649831020943 putative PBP binding loops; other site 649831020944 ABC-ATPase subunit interface; other site 649831020945 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 649831020946 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649831020947 dimer interface [polypeptide binding]; other site 649831020948 conserved gate region; other site 649831020949 ABC-ATPase subunit interface; other site 649831020950 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 649831020951 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 649831020952 Walker A/P-loop; other site 649831020953 ATP binding site [chemical binding]; other site 649831020954 Q-loop/lid; other site 649831020955 ABC transporter signature motif; other site 649831020956 Walker B; other site 649831020957 D-loop; other site 649831020958 H-loop/switch region; other site 649831020959 NUDIX domain; Region: NUDIX; pfam00293 649831020960 nudix motif; other site 649831020961 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 649831020962 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 649831020963 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 649831020964 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 649831020965 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 649831020966 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 649831020967 catalytic site [active] 649831020968 active site 649831020969 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 649831020970 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 649831020971 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 649831020972 DNA binding residues [nucleotide binding] 649831020973 Protein of unknown function (DUF402); Region: DUF402; cl00979 649831020974 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 649831020975 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 649831020976 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 649831020977 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 649831020978 Domain of unknown function DUF20; Region: UPF0118; pfam01594 649831020979 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 649831020980 oligomerisation interface [polypeptide binding]; other site 649831020981 mobile loop; other site 649831020982 roof hairpin; other site 649831020983 Protease prsW family; Region: PrsW-protease; pfam13367 649831020984 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339 649831020985 Protein of unknown function (DUF4031); Region: DUF4031; pfam13223 649831020986 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 649831020987 conserved repeat domain; Region: B_ant_repeat; TIGR01451 649831020988 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 649831020989 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 649831020990 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 649831020991 ring oligomerisation interface [polypeptide binding]; other site 649831020992 ATP/Mg binding site [chemical binding]; other site 649831020993 stacking interactions; other site 649831020994 hinge regions; other site 649831020995 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 649831020996 active site 649831020997 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 649831020998 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 649831020999 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 649831021000 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 649831021001 Coenzyme A binding pocket [chemical binding]; other site 649831021002 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 649831021003 Coenzyme A binding pocket [chemical binding]; other site 649831021004 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 649831021005 threonine synthase; Validated; Region: PRK07591 649831021006 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 649831021007 homodimer interface [polypeptide binding]; other site 649831021008 pyridoxal 5'-phosphate binding site [chemical binding]; other site 649831021009 catalytic residue [active] 649831021010 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 649831021011 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 649831021012 Walker A/P-loop; other site 649831021013 ATP binding site [chemical binding]; other site 649831021014 Q-loop/lid; other site 649831021015 ABC transporter signature motif; other site 649831021016 Walker B; other site 649831021017 D-loop; other site 649831021018 H-loop/switch region; other site 649831021019 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 649831021020 Cell division protein 48 (CDC48) N-terminal domain; Region: CDC48_N; smart01073 649831021021 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 649831021022 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 649831021023 Walker A motif; other site 649831021024 ATP binding site [chemical binding]; other site 649831021025 Walker B motif; other site 649831021026 arginine finger; other site 649831021027 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 649831021028 Walker A motif; other site 649831021029 ATP binding site [chemical binding]; other site 649831021030 Walker B motif; other site 649831021031 arginine finger; other site 649831021032 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 649831021033 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 649831021034 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 649831021035 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 649831021036 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 649831021037 Walker A/P-loop; other site 649831021038 ATP binding site [chemical binding]; other site 649831021039 Q-loop/lid; other site 649831021040 ABC transporter signature motif; other site 649831021041 Walker B; other site 649831021042 D-loop; other site 649831021043 H-loop/switch region; other site 649831021044 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 649831021045 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 649831021046 non-specific DNA binding site [nucleotide binding]; other site 649831021047 salt bridge; other site 649831021048 sequence-specific DNA binding site [nucleotide binding]; other site 649831021049 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 649831021050 active site 649831021051 substrate binding site [chemical binding]; other site 649831021052 ATP binding site [chemical binding]; other site 649831021053 Phosphotransferase enzyme family; Region: APH; pfam01636 649831021054 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 649831021055 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 649831021056 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 649831021057 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 649831021058 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 649831021059 dimer interface [polypeptide binding]; other site 649831021060 active site 649831021061 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 649831021062 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 649831021063 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 649831021064 nucleotide binding site [chemical binding]; other site 649831021065 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 649831021066 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 649831021067 active site 649831021068 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 649831021069 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 649831021070 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 649831021071 DNA binding site [nucleotide binding] 649831021072 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 649831021073 NB-ARC domain; Region: NB-ARC; pfam00931 649831021074 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 649831021075 active site 649831021076 Tetratricopeptide repeat; Region: TPR_12; pfam13424 649831021077 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 649831021078 binding surface 649831021079 Tetratricopeptide repeat; Region: TPR_12; pfam13424 649831021080 TPR motif; other site 649831021081 Tetratricopeptide repeat; Region: TPR_12; pfam13424 649831021082 fumarate hydratase; Reviewed; Region: fumC; PRK00485 649831021083 Class II fumarases; Region: Fumarase_classII; cd01362 649831021084 active site 649831021085 tetramer interface [polypeptide binding]; other site 649831021086 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 649831021087 active site 649831021088 catalytic residues [active] 649831021089 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 649831021090 catalytic residues [active] 649831021091 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 649831021092 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 649831021093 active site 649831021094 HIGH motif; other site 649831021095 nucleotide binding site [chemical binding]; other site 649831021096 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 649831021097 KMSKS motif; other site 649831021098 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 649831021099 tRNA binding surface [nucleotide binding]; other site 649831021100 anticodon binding site; other site 649831021101 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 649831021102 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 649831021103 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 649831021104 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 649831021105 nucleotide binding site [chemical binding]; other site 649831021106 putative NEF/HSP70 interaction site [polypeptide binding]; other site 649831021107 SBD interface [polypeptide binding]; other site 649831021108 PQQ-like domain; Region: PQQ_2; pfam13360 649831021109 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 649831021110 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 649831021111 Walker A/P-loop; other site 649831021112 ATP binding site [chemical binding]; other site 649831021113 Q-loop/lid; other site 649831021114 ABC transporter signature motif; other site 649831021115 Walker B; other site 649831021116 D-loop; other site 649831021117 H-loop/switch region; other site 649831021118 TOBE domain; Region: TOBE_2; pfam08402 649831021119 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649831021120 S-adenosylmethionine binding site [chemical binding]; other site 649831021121 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 649831021122 Coenzyme A binding pocket [chemical binding]; other site 649831021123 TrkA-N domain; Region: TrkA_N; pfam02254 649831021124 fumarate hydratase; Provisional; Region: PRK15389 649831021125 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 649831021126 Fumarase C-terminus; Region: Fumerase_C; pfam05683 649831021127 PQQ-like domain; Region: PQQ_2; pfam13360 649831021128 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 649831021129 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 649831021130 AsnC family; Region: AsnC_trans_reg; pfam01037 649831021131 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 649831021132 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 649831021133 dimer interface [polypeptide binding]; other site 649831021134 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 649831021135 active site 649831021136 Fe binding site [ion binding]; other site 649831021137 RDD family; Region: RDD; pfam06271 649831021138 RDD family; Region: RDD; pfam06271 649831021139 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 649831021140 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 649831021141 pyridoxal 5'-phosphate binding site [chemical binding]; other site 649831021142 homodimer interface [polypeptide binding]; other site 649831021143 catalytic residue [active] 649831021144 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 649831021145 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 649831021146 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 649831021147 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 649831021148 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 649831021149 hydrophobic ligand binding site; other site 649831021150 fumarylacetoacetase; Region: fum_ac_acetase; TIGR01266 649831021151 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 649831021152 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 649831021153 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 649831021154 Glycosyl hydrolase family 46 chitosanase domain. This family are composed of the chitosanase enzymes which hydrolyzes chitosan, a biopolymer of beta (1,4)-linked -D-glucosamine (GlcN) residues produced by partial or full deacetylation of chitin; Region: chitosanase_glyco_hydro_46; cd00978 649831021155 chitosan binding site [chemical binding]; other site 649831021156 catalytic residues [active] 649831021157 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 649831021158 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 649831021159 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 649831021160 TPR motif; other site 649831021161 binding surface 649831021162 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 649831021163 homotrimer interaction site [polypeptide binding]; other site 649831021164 zinc binding site [ion binding]; other site 649831021165 CDP-binding sites; other site 649831021166 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 649831021167 substrate binding site; other site 649831021168 dimer interface; other site 649831021169 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 649831021170 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 649831021171 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 649831021172 malonyl-CoA binding site [chemical binding]; other site 649831021173 dimer interface [polypeptide binding]; other site 649831021174 active site 649831021175 product binding site; other site 649831021176 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 649831021177 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 649831021178 active site 649831021179 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 649831021180 active site 649831021181 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1, 4-benzoquinol methylase [Coenzyme metabolism]; Region: UbiG; COG2227 649831021182 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 649831021183 DNA repair protein RadA; Provisional; Region: PRK11823 649831021184 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 649831021185 Walker A motif; other site 649831021186 ATP binding site [chemical binding]; other site 649831021187 Walker B motif; other site 649831021188 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 649831021189 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 649831021190 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 649831021191 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 649831021192 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 649831021193 minor groove reading motif; other site 649831021194 helix-hairpin-helix signature motif; other site 649831021195 substrate binding pocket [chemical binding]; other site 649831021196 active site 649831021197 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 649831021198 Domain of unknown function (DUF4291); Region: DUF4291; pfam14124 649831021199 Domain of unknown function (DUF4291); Region: DUF4291; pfam14124 649831021200 Clp protease ATP binding subunit; Region: clpC; CHL00095 649831021201 Clp amino terminal domain; Region: Clp_N; pfam02861 649831021202 Clp amino terminal domain; Region: Clp_N; pfam02861 649831021203 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 649831021204 Walker A motif; other site 649831021205 ATP binding site [chemical binding]; other site 649831021206 Walker B motif; other site 649831021207 arginine finger; other site 649831021208 UvrB/uvrC motif; Region: UVR; pfam02151 649831021209 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 649831021210 Walker A motif; other site 649831021211 ATP binding site [chemical binding]; other site 649831021212 Walker B motif; other site 649831021213 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 649831021214 Lsr2; Region: Lsr2; pfam11774 649831021215 pantothenate kinase; Reviewed; Region: PRK13318 649831021216 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 649831021217 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 649831021218 dimerization interface [polypeptide binding]; other site 649831021219 active site 649831021220 L-aspartate oxidase; Provisional; Region: PRK07804 649831021221 L-aspartate oxidase; Provisional; Region: PRK06175 649831021222 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 649831021223 Septum formation; Region: Septum_form; pfam13845 649831021224 Septum formation; Region: Septum_form; pfam13845 649831021225 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 649831021226 tetramerization interface [polypeptide binding]; other site 649831021227 active site 649831021228 Pantoate-beta-alanine ligase; Region: PanC; cd00560 649831021229 active site 649831021230 ATP-binding site [chemical binding]; other site 649831021231 pantoate-binding site; other site 649831021232 HXXH motif; other site 649831021233 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 649831021234 Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636 649831021235 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 649831021236 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 649831021237 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 649831021238 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 649831021239 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649831021240 ABC-ATPase subunit interface; other site 649831021241 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 649831021242 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 649831021243 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 649831021244 Walker A/P-loop; other site 649831021245 ATP binding site [chemical binding]; other site 649831021246 Q-loop/lid; other site 649831021247 ABC transporter signature motif; other site 649831021248 Walker B; other site 649831021249 D-loop; other site 649831021250 H-loop/switch region; other site 649831021251 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 649831021252 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 649831021253 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 649831021254 catalytic center binding site [active] 649831021255 ATP binding site [chemical binding]; other site 649831021256 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 649831021257 homooctamer interface [polypeptide binding]; other site 649831021258 active site 649831021259 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 649831021260 dihydropteroate synthase; Region: DHPS; TIGR01496 649831021261 substrate binding pocket [chemical binding]; other site 649831021262 dimer interface [polypeptide binding]; other site 649831021263 inhibitor binding site; inhibition site 649831021264 AAA-like domain; Region: AAA_10; pfam12846 649831021265 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 649831021266 Peptidase family M23; Region: Peptidase_M23; pfam01551 649831021267 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 649831021268 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 649831021269 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 649831021270 active site 649831021271 FtsH Extracellular; Region: FtsH_ext; pfam06480 649831021272 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 649831021273 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 649831021274 Walker A motif; other site 649831021275 ATP binding site [chemical binding]; other site 649831021276 Walker B motif; other site 649831021277 arginine finger; other site 649831021278 Peptidase family M41; Region: Peptidase_M41; pfam01434 649831021279 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 649831021280 active site 649831021281 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 649831021282 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 649831021283 Ligand Binding Site [chemical binding]; other site 649831021284 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 649831021285 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 649831021286 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 649831021287 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 649831021288 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 649831021289 dimer interface [polypeptide binding]; other site 649831021290 substrate binding site [chemical binding]; other site 649831021291 metal binding sites [ion binding]; metal-binding site 649831021292 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 649831021293 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 649831021294 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 649831021295 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 649831021296 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 649831021297 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 649831021298 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 649831021299 active site 649831021300 catalytic residues [active] 649831021301 Colicin V production protein; Region: Colicin_V; pfam02674 649831021302 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 649831021303 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 649831021304 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 649831021305 putative active site [active] 649831021306 putative CoA binding site [chemical binding]; other site 649831021307 nudix motif; other site 649831021308 metal binding site [ion binding]; metal-binding site 649831021309 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 649831021310 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 649831021311 catalytic residues [active] 649831021312 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 649831021313 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 649831021314 minor groove reading motif; other site 649831021315 helix-hairpin-helix signature motif; other site 649831021316 substrate binding pocket [chemical binding]; other site 649831021317 active site 649831021318 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 649831021319 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 649831021320 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 649831021321 putative active site [active] 649831021322 putative metal binding site [ion binding]; other site 649831021323 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 649831021324 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 649831021325 ligand binding site [chemical binding]; other site 649831021326 flexible hinge region; other site 649831021327 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 649831021328 non-specific DNA interactions [nucleotide binding]; other site 649831021329 DNA binding site [nucleotide binding] 649831021330 sequence specific DNA binding site [nucleotide binding]; other site 649831021331 putative cAMP binding site [chemical binding]; other site 649831021332 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 649831021333 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 649831021334 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 649831021335 ATP-grasp domain; Region: ATP-grasp_4; cl17255 649831021336 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 649831021337 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 649831021338 carboxyltransferase (CT) interaction site; other site 649831021339 biotinylation site [posttranslational modification]; other site 649831021340 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 649831021341 cyclase homology domain; Region: CHD; cd07302 649831021342 nucleotidyl binding site; other site 649831021343 metal binding site [ion binding]; metal-binding site 649831021344 dimer interface [polypeptide binding]; other site 649831021345 AAA ATPase domain; Region: AAA_16; pfam13191 649831021346 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 649831021347 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 649831021348 homotrimer interaction site [polypeptide binding]; other site 649831021349 putative active site [active] 649831021350 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 649831021351 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 649831021352 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 649831021353 DTAP/Switch II; other site 649831021354 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 649831021355 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 649831021356 DTAP/Switch II; other site 649831021357 Switch I; other site 649831021358 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 649831021359 Transcription factor WhiB; Region: Whib; pfam02467 649831021360 Transglycosylase; Region: Transgly; pfam00912 649831021361 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 649831021362 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 649831021363 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 649831021364 Yqey-like protein; Region: YqeY; pfam09424 649831021365 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 649831021366 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 649831021367 putative active site [active] 649831021368 putative metal binding site [ion binding]; other site 649831021369 A subgroup of the Glycosyl hydrolase family 20 (GH20) catalytic domain found in proteins similar to the N-acetylhexosaminidase from Streptomyces plicatus (SpHex). SpHex catalyzes the hydrolysis of N-acetyl-beta-hexosaminides. An Asp residue within the...; Region: GH20_SpHex_like; cd06568 649831021370 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 649831021371 active site 649831021372 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 649831021373 2-isopropylmalate synthase; Validated; Region: PRK03739 649831021374 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 649831021375 active site 649831021376 catalytic residues [active] 649831021377 metal binding site [ion binding]; metal-binding site 649831021378 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 649831021379 aspartate kinase; Reviewed; Region: PRK06635 649831021380 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 649831021381 putative nucleotide binding site [chemical binding]; other site 649831021382 putative catalytic residues [active] 649831021383 putative Mg ion binding site [ion binding]; other site 649831021384 putative aspartate binding site [chemical binding]; other site 649831021385 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 649831021386 putative allosteric regulatory site; other site 649831021387 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 649831021388 putative allosteric regulatory residue; other site 649831021389 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 649831021390 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 649831021391 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 649831021392 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 649831021393 aromatic chitin/cellulose binding site residues [chemical binding]; other site 649831021394 Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046 649831021395 aromatic chitin/cellulose binding site residues [chemical binding]; other site 649831021396 Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but some...; Region: chitinase_glyco_hydro_19; cd00325 649831021397 putative sugar binding site [chemical binding]; other site 649831021398 catalytic residues [active] 649831021399 GAF domain; Region: GAF_3; pfam13492 649831021400 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 649831021401 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 649831021402 metal binding site [ion binding]; metal-binding site 649831021403 active site 649831021404 I-site; other site 649831021405 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 649831021406 Uncharacterized conserved protein [Function unknown]; Region: COG3287 649831021407 FIST N domain; Region: FIST; pfam08495 649831021408 FIST C domain; Region: FIST_C; pfam10442 649831021409 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 649831021410 active site 649831021411 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 649831021412 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 649831021413 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 649831021414 DNA binding residues [nucleotide binding] 649831021415 putative dimer interface [polypeptide binding]; other site 649831021416 Predicted transcriptional regulator [Transcription]; Region: COG2378 649831021417 HTH domain; Region: HTH_11; pfam08279 649831021418 WYL domain; Region: WYL; pfam13280 649831021419 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 649831021420 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 649831021421 active site 649831021422 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 649831021423 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 649831021424 Walker A/P-loop; other site 649831021425 ATP binding site [chemical binding]; other site 649831021426 Q-loop/lid; other site 649831021427 ABC transporter signature motif; other site 649831021428 Walker B; other site 649831021429 D-loop; other site 649831021430 H-loop/switch region; other site 649831021431 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 649831021432 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 649831021433 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 649831021434 Walker A/P-loop; other site 649831021435 ATP binding site [chemical binding]; other site 649831021436 Q-loop/lid; other site 649831021437 ABC transporter signature motif; other site 649831021438 Walker B; other site 649831021439 D-loop; other site 649831021440 H-loop/switch region; other site 649831021441 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 649831021442 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 649831021443 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649831021444 dimer interface [polypeptide binding]; other site 649831021445 conserved gate region; other site 649831021446 putative PBP binding loops; other site 649831021447 ABC-ATPase subunit interface; other site 649831021448 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 649831021449 The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506 649831021450 peptide binding site [polypeptide binding]; other site 649831021451 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 649831021452 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 649831021453 dimer interface [polypeptide binding]; other site 649831021454 conserved gate region; other site 649831021455 putative PBP binding loops; other site 649831021456 ABC-ATPase subunit interface; other site 649831021457 recombination protein RecR; Reviewed; Region: recR; PRK00076 649831021458 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 649831021459 RecR protein; Region: RecR; pfam02132 649831021460 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 649831021461 putative active site [active] 649831021462 putative metal-binding site [ion binding]; other site 649831021463 tetramer interface [polypeptide binding]; other site 649831021464 hypothetical protein; Validated; Region: PRK00153 649831021465 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 649831021466 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 649831021467 Walker A motif; other site 649831021468 ATP binding site [chemical binding]; other site 649831021469 Walker B motif; other site 649831021470 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 649831021471 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 649831021472 salt bridge; other site 649831021473 non-specific DNA binding site [nucleotide binding]; other site 649831021474 sequence-specific DNA binding site [nucleotide binding]; other site 649831021475 SnoaL-like domain; Region: SnoaL_2; pfam12680 649831021476 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831021477 short chain dehydrogenase; Provisional; Region: PRK07041 649831021478 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831021479 NAD(P) binding site [chemical binding]; other site 649831021480 active site 649831021481 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 649831021482 anti sigma factor interaction site; other site 649831021483 regulatory phosphorylation site [posttranslational modification]; other site 649831021484 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 649831021485 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 649831021486 transmembrane helices; other site 649831021487 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 649831021488 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 649831021489 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 649831021490 nucleoside/Zn binding site; other site 649831021491 dimer interface [polypeptide binding]; other site 649831021492 catalytic motif [active] 649831021493 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 649831021494 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 649831021495 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 649831021496 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 649831021497 active site 649831021498 DNA binding site [nucleotide binding] 649831021499 Int/Topo IB signature motif; other site 649831021500 Helix-turn-helix domain; Region: HTH_17; cl17695 649831021501 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 649831021502 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 649831021503 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 649831021504 NUDIX domain; Region: NUDIX; pfam00293 649831021505 nudix motif; other site 649831021506 Protein of unknown function (DUF664); Region: DUF664; pfam04978 649831021507 DinB superfamily; Region: DinB_2; pfam12867 649831021508 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 649831021509 prephenate dehydrogenase; Validated; Region: PRK08507 649831021510 Peptidase family M23; Region: Peptidase_M23; pfam01551 649831021511 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 649831021512 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 649831021513 hypothetical protein; Provisional; Region: PRK07945 649831021514 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 649831021515 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 649831021516 active site 649831021517 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 649831021518 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831021519 ATP binding site [chemical binding]; other site 649831021520 Mg2+ binding site [ion binding]; other site 649831021521 G-X-G motif; other site 649831021522 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 649831021523 Protein of unknown function (DUF742); Region: DUF742; pfam05331 649831021524 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 649831021525 ATPase involved in DNA repair; Region: DUF3686; pfam12458 649831021526 AAA domain; Region: AAA_22; pfam13401 649831021527 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 649831021528 Walker A motif; other site 649831021529 ATP binding site [chemical binding]; other site 649831021530 Walker B motif; other site 649831021531 arginine finger; other site 649831021532 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 649831021533 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 649831021534 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 649831021535 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 649831021536 active site 649831021537 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 649831021538 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 649831021539 active site 649831021540 homodimer interface [polypeptide binding]; other site 649831021541 Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG5298; cd10923 649831021542 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 649831021543 NodB motif; other site 649831021544 putative active site [active] 649831021545 putative catalytic site [active] 649831021546 putative Zn binding site [ion binding]; other site 649831021547 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 649831021548 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 649831021549 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 649831021550 Cellulose binding domain; Region: CBM_2; pfam00553 649831021551 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 649831021552 active site 649831021553 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 649831021554 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831021555 MarR family; Region: MarR_2; pfam12802 649831021556 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831021557 putative substrate translocation pore; other site 649831021558 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831021559 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831021560 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831021561 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 649831021562 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 649831021563 metal binding site [ion binding]; metal-binding site 649831021564 active site 649831021565 I-site; other site 649831021566 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 649831021567 Nitroreductase family; Region: Nitroreductase; pfam00881 649831021568 FMN binding site [chemical binding]; other site 649831021569 dimer interface [polypeptide binding]; other site 649831021570 Domain of unknown function (DUF397); Region: DUF397; pfam04149 649831021571 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 649831021572 non-specific DNA binding site [nucleotide binding]; other site 649831021573 salt bridge; other site 649831021574 sequence-specific DNA binding site [nucleotide binding]; other site 649831021575 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 649831021576 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 649831021577 ATP binding site [chemical binding]; other site 649831021578 active site 649831021579 substrate binding site [chemical binding]; other site 649831021580 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 649831021581 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 649831021582 cofactor binding site; other site 649831021583 DNA binding site [nucleotide binding] 649831021584 substrate interaction site [chemical binding]; other site 649831021585 Restriction endonuclease NaeI; Region: NaeI; pfam09126 649831021586 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 649831021587 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831021588 active site 649831021589 phosphorylation site [posttranslational modification] 649831021590 intermolecular recognition site; other site 649831021591 dimerization interface [polypeptide binding]; other site 649831021592 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 649831021593 DNA binding site [nucleotide binding] 649831021594 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 649831021595 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 649831021596 dimerization interface [polypeptide binding]; other site 649831021597 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831021598 ATP binding site [chemical binding]; other site 649831021599 Mg2+ binding site [ion binding]; other site 649831021600 G-X-G motif; other site 649831021601 Chitin binding domain; Region: Chitin_bind_3; pfam03067 649831021602 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 649831021603 Domain of unknown function (DUF305); Region: DUF305; pfam03713 649831021604 H+ Antiporter protein; Region: 2A0121; TIGR00900 649831021605 HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795 649831021606 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 649831021607 active site 649831021608 metal binding site [ion binding]; metal-binding site 649831021609 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 649831021610 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 649831021611 Domain of unknown function (DUF385); Region: DUF385; pfam04075 649831021612 MTH538 TIR-like domain (DUF1863); Region: DUF1863; pfam08937 649831021613 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 649831021614 ligand binding site [chemical binding]; other site 649831021615 TIR domain; Region: TIR_2; pfam13676 649831021616 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649831021617 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831021618 active site 649831021619 phosphorylation site [posttranslational modification] 649831021620 intermolecular recognition site; other site 649831021621 dimerization interface [polypeptide binding]; other site 649831021622 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649831021623 DNA binding residues [nucleotide binding] 649831021624 dimerization interface [polypeptide binding]; other site 649831021625 Histidine kinase; Region: HisKA_3; pfam07730 649831021626 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831021627 ATP binding site [chemical binding]; other site 649831021628 Mg2+ binding site [ion binding]; other site 649831021629 G-X-G motif; other site 649831021630 CAAX protease self-immunity; Region: Abi; pfam02517 649831021631 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 649831021632 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831021633 active site 649831021634 phosphorylation site [posttranslational modification] 649831021635 intermolecular recognition site; other site 649831021636 dimerization interface [polypeptide binding]; other site 649831021637 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 649831021638 DNA binding site [nucleotide binding] 649831021639 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 649831021640 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 649831021641 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 649831021642 dimer interface [polypeptide binding]; other site 649831021643 phosphorylation site [posttranslational modification] 649831021644 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831021645 ATP binding site [chemical binding]; other site 649831021646 Mg2+ binding site [ion binding]; other site 649831021647 G-X-G motif; other site 649831021648 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 649831021649 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 649831021650 Walker A/P-loop; other site 649831021651 ATP binding site [chemical binding]; other site 649831021652 Q-loop/lid; other site 649831021653 ABC transporter signature motif; other site 649831021654 Walker B; other site 649831021655 D-loop; other site 649831021656 H-loop/switch region; other site 649831021657 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 649831021658 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 649831021659 FtsX-like permease family; Region: FtsX; pfam02687 649831021660 Major Facilitator Superfamily; Region: MFS_1; pfam07690 649831021661 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 649831021662 putative substrate translocation pore; other site 649831021663 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 649831021664 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 649831021665 dimerization interface [polypeptide binding]; other site 649831021666 putative DNA binding site [nucleotide binding]; other site 649831021667 putative Zn2+ binding site [ion binding]; other site 649831021668 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 649831021669 Low molecular weight phosphatase family; Region: LMWPc; cd00115 649831021670 active site 649831021671 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831021672 SnoaL-like domain; Region: SnoaL_4; pfam13577 649831021673 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 649831021674 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 649831021675 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 649831021676 hypothetical protein; Provisional; Region: PRK07236 649831021677 hypothetical protein; Validated; Region: PRK05868 649831021678 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 649831021679 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 649831021680 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 649831021681 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 649831021682 MarR family; Region: MarR_2; pfam12802 649831021683 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 649831021684 Histidine kinase; Region: HisKA_3; pfam07730 649831021685 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831021686 ATP binding site [chemical binding]; other site 649831021687 Mg2+ binding site [ion binding]; other site 649831021688 G-X-G motif; other site 649831021689 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 649831021690 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831021691 active site 649831021692 phosphorylation site [posttranslational modification] 649831021693 intermolecular recognition site; other site 649831021694 dimerization interface [polypeptide binding]; other site 649831021695 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 649831021696 DNA binding residues [nucleotide binding] 649831021697 dimerization interface [polypeptide binding]; other site 649831021698 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 649831021699 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 649831021700 short chain dehydrogenase; Provisional; Region: PRK06197 649831021701 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 649831021702 putative NAD(P) binding site [chemical binding]; other site 649831021703 active site 649831021704 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 649831021705 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 649831021706 NAD(P) binding site [chemical binding]; other site 649831021707 active site 649831021708 Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067 649831021709 Cupin; Region: Cupin_6; pfam12852 649831021710 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 649831021711 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 649831021712 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 649831021713 CAAX protease self-immunity; Region: Abi; pfam02517 649831021714 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 649831021715 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 649831021716 heme-binding site [chemical binding]; other site 649831021717 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 649831021718 FAD binding pocket [chemical binding]; other site 649831021719 FAD binding motif [chemical binding]; other site 649831021720 phosphate binding motif [ion binding]; other site 649831021721 beta-alpha-beta structure motif; other site 649831021722 NAD binding pocket [chemical binding]; other site 649831021723 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 649831021724 active site 649831021725 catalytic residues [active] 649831021726 metal binding site [ion binding]; metal-binding site 649831021727 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131 649831021728 Methyltransferase domain; Region: Methyltransf_23; pfam13489 649831021729 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 649831021730 S-adenosylmethionine binding site [chemical binding]; other site 649831021731 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 649831021732 substrate binding site [chemical binding]; other site 649831021733 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 649831021734 GAF domain; Region: GAF; pfam01590 649831021735 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 649831021736 dimer interface [polypeptide binding]; other site 649831021737 phosphorylation site [posttranslational modification] 649831021738 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831021739 ATP binding site [chemical binding]; other site 649831021740 Mg2+ binding site [ion binding]; other site 649831021741 G-X-G motif; other site 649831021742 NlpC/P60 family; Region: NLPC_P60; cl17555 649831021743 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 649831021744 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 649831021745 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 649831021746 active site 649831021747 Predicted flavoprotein [General function prediction only]; Region: COG0431 649831021748 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 649831021749 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 649831021750 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 649831021751 NAD(P) binding site [chemical binding]; other site 649831021752 Ricin-type beta-trefoil; Region: RICIN; smart00458 649831021753 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 649831021754 putative sugar binding sites [chemical binding]; other site 649831021755 Q-X-W motif; other site 649831021756 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 649831021757 active site 649831021758 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 649831021759 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 649831021760 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 649831021761 active site 649831021762 NAD binding site [chemical binding]; other site 649831021763 metal binding site [ion binding]; metal-binding site 649831021764 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 649831021765 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 649831021766 active site 649831021767 metal-binding site 649831021768 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 649831021769 nudix motif; other site 649831021770 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 649831021771 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 649831021772 pyridoxal 5'-phosphate binding site [chemical binding]; other site 649831021773 homodimer interface [polypeptide binding]; other site 649831021774 catalytic residue [active] 649831021775 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 649831021776 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 649831021777 oligomer interface [polypeptide binding]; other site 649831021778 metal binding site [ion binding]; metal-binding site 649831021779 metal binding site [ion binding]; metal-binding site 649831021780 putative Cl binding site [ion binding]; other site 649831021781 basic sphincter; other site 649831021782 hydrophobic gate; other site 649831021783 periplasmic entrance; other site 649831021784 Protein of unknown function (DUF690); Region: DUF690; cl04939 649831021785 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 649831021786 active site 649831021787 Rhomboid family; Region: Rhomboid; pfam01694 649831021788 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 649831021789 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 649831021790 dimer interface [polypeptide binding]; other site 649831021791 active site 649831021792 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 649831021793 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 649831021794 PYR/PP interface [polypeptide binding]; other site 649831021795 dimer interface [polypeptide binding]; other site 649831021796 TPP binding site [chemical binding]; other site 649831021797 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 649831021798 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 649831021799 TPP-binding site [chemical binding]; other site 649831021800 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 649831021801 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 649831021802 DNA binding residues [nucleotide binding] 649831021803 dimer interface [polypeptide binding]; other site 649831021804 [2Fe-2S] cluster binding site [ion binding]; other site 649831021805 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 649831021806 putative active site [active] 649831021807 Arylsulfotransferase (ASST); Region: Arylsulfotran_2; pfam14269 649831021808 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 649831021809 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 649831021810 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 649831021811 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 649831021812 putative H2TH interface [polypeptide binding]; other site 649831021813 putative DNA binding site [nucleotide binding]; other site 649831021814 putative catalytic residues [active] 649831021815 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 649831021816 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 649831021817 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 649831021818 Bacterial sugar transferase; Region: Bac_transf; pfam02397 649831021819 Histidine kinase; Region: His_kinase; pfam06580 649831021820 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831021821 ATP binding site [chemical binding]; other site 649831021822 Mg2+ binding site [ion binding]; other site 649831021823 G-X-G motif; other site 649831021824 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 649831021825 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831021826 active site 649831021827 phosphorylation site [posttranslational modification] 649831021828 intermolecular recognition site; other site 649831021829 dimerization interface [polypeptide binding]; other site 649831021830 LytTr DNA-binding domain; Region: LytTR; smart00850 649831021831 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 649831021832 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 649831021833 active site 649831021834 phosphorylation site [posttranslational modification] 649831021835 intermolecular recognition site; other site 649831021836 dimerization interface [polypeptide binding]; other site 649831021837 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 649831021838 DNA binding site [nucleotide binding] 649831021839 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 649831021840 dimerization interface [polypeptide binding]; other site 649831021841 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 649831021842 dimer interface [polypeptide binding]; other site 649831021843 phosphorylation site [posttranslational modification] 649831021844 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831021845 ATP binding site [chemical binding]; other site 649831021846 Mg2+ binding site [ion binding]; other site 649831021847 G-X-G motif; other site 649831021848 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 649831021849 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 649831021850 Na binding site [ion binding]; other site 649831021851 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 649831021852 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 649831021853 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 649831021854 Walker A/P-loop; other site 649831021855 ATP binding site [chemical binding]; other site 649831021856 Q-loop/lid; other site 649831021857 ABC transporter signature motif; other site 649831021858 Walker B; other site 649831021859 D-loop; other site 649831021860 H-loop/switch region; other site 649831021861 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 649831021862 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 649831021863 active site 649831021864 HIGH motif; other site 649831021865 dimer interface [polypeptide binding]; other site 649831021866 KMSKS motif; other site 649831021867 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 649831021868 Protein of unknown function, DUF485; Region: DUF485; pfam04341 649831021869 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 649831021870 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 649831021871 Na binding site [ion binding]; other site 649831021872 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 649831021873 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 649831021874 NAD binding site [chemical binding]; other site 649831021875 putative substrate binding site 2 [chemical binding]; other site 649831021876 putative substrate binding site 1 [chemical binding]; other site 649831021877 active site 649831021878 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 649831021879 Transcriptional regulator [Transcription]; Region: LytR; COG1316 649831021880 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 649831021881 active site residue [active] 649831021882 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 649831021883 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 649831021884 active site 649831021885 catalytic site [active] 649831021886 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 649831021887 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 649831021888 dimer interface [polypeptide binding]; other site 649831021889 phosphorylation site [posttranslational modification] 649831021890 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 649831021891 ATP binding site [chemical binding]; other site 649831021892 Mg2+ binding site [ion binding]; other site 649831021893 G-X-G motif; other site 649831021894 arginine deiminase; Provisional; Region: PRK01388 649831021895 Family description; Region: ACT_7; pfam13840 649831021896 prephenate dehydratase; Provisional; Region: PRK11898 649831021897 Prephenate dehydratase; Region: PDT; pfam00800 649831021898 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 649831021899 putative L-Phe binding site [chemical binding]; other site 649831021900 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 649831021901 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 649831021902 DNA binding residues [nucleotide binding] 649831021903 putative dimer interface [polypeptide binding]; other site 649831021904 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 649831021905 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 649831021906 putative NAD(P) binding site [chemical binding]; other site 649831021907 putative substrate binding site [chemical binding]; other site 649831021908 catalytic Zn binding site [ion binding]; other site 649831021909 structural Zn binding site [ion binding]; other site 649831021910 dimer interface [polypeptide binding]; other site 649831021911 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 649831021912 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 649831021913 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 649831021914 seryl-tRNA synthetase; Provisional; Region: PRK05431 649831021915 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 649831021916 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 649831021917 motif 1; other site 649831021918 dimer interface [polypeptide binding]; other site 649831021919 active site 649831021920 motif 2; other site 649831021921 motif 3; other site 649831021922 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 649831021923 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 649831021924 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 649831021925 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 649831021926 active site 649831021927 motif I; other site 649831021928 motif II; other site 649831021929 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 649831021930 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 649831021931 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 649831021932 Amidinotransferase; Region: Amidinotransf; cl12043 649831021933 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 649831021934 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 649831021935 AsnC family; Region: AsnC_trans_reg; pfam01037 649831021936 Beta propeller domain; Region: Beta_propel; pfam09826 649831021937 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 649831021938 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 649831021939 PhoD-like phosphatase; Region: PhoD; pfam09423 649831021940 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 649831021941 putative active site [active] 649831021942 putative metal binding site [ion binding]; other site 649831021943 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 649831021944 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 649831021945 Coenzyme A binding pocket [chemical binding]; other site 649831021946 Fructosamine kinase; Region: Fructosamin_kin; cl17579 649831021947 Phosphotransferase enzyme family; Region: APH; pfam01636 649831021948 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 649831021949 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 649831021950 FeS/SAM binding site; other site 649831021951 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 649831021952 Ubiquitin-like proteins; Region: UBQ; cl00155 649831021953 charged pocket; other site 649831021954 hydrophobic patch; other site 649831021955 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 649831021956 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 649831021957 putative active site [active] 649831021958 putative metal binding site [ion binding]; other site 649831021959 PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379 649831021960 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 649831021961 active site 649831021962 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 649831021963 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 649831021964 Walker A motif; other site 649831021965 ATP binding site [chemical binding]; other site 649831021966 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 649831021967 Family description; Region: UvrD_C_2; pfam13538 649831021968 AAA ATPase domain; Region: AAA_16; pfam13191 649831021969 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 649831021970 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 649831021971 MoaE homodimer interface [polypeptide binding]; other site 649831021972 MoaD interaction [polypeptide binding]; other site 649831021973 active site residues [active] 649831021974 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 649831021975 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 649831021976 dimer interface [polypeptide binding]; other site 649831021977 putative functional site; other site 649831021978 putative MPT binding site; other site 649831021979 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 649831021980 MPT binding site; other site 649831021981 trimer interface [polypeptide binding]; other site 649831021982 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 649831021983 trimer interface [polypeptide binding]; other site 649831021984 dimer interface [polypeptide binding]; other site 649831021985 putative active site [active] 649831021986 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 649831021987 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 649831021988 metal binding site [ion binding]; metal-binding site 649831021989 active site 649831021990 I-site; other site 649831021991 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 649831021992 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 649831021993 YwqJ-like deaminase; Region: YwqJ-deaminase; pfam14431 649831021994 SUKH-3 immunity protein; Region: SUKH-3; pfam14433 649831021995 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 649831021996 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 649831021997 metal binding triad [ion binding]; metal-binding site 649831021998 replicative DNA helicase; Region: DnaB; TIGR00665 649831021999 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 649831022000 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 649831022001 Walker A motif; other site 649831022002 ATP binding site [chemical binding]; other site 649831022003 Walker B motif; other site 649831022004 DNA binding loops [nucleotide binding] 649831022005 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 649831022006 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 649831022007 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 649831022008 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 649831022009 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 649831022010 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 649831022011 dimer interface [polypeptide binding]; other site 649831022012 ssDNA binding site [nucleotide binding]; other site 649831022013 tetramer (dimer of dimers) interface [polypeptide binding]; other site 649831022014 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 649831022015 AP endonuclease family 2; Region: AP2Ec; smart00518 649831022016 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 649831022017 AP (apurinic/apyrimidinic) site pocket; other site 649831022018 DNA interaction; other site 649831022019 Metal-binding active site; metal-binding site 649831022020 Predicted integral membrane protein [Function unknown]; Region: COG5650 649831022021 Transglycosylase; Region: Transgly; pfam00912 649831022022 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 649831022023 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 649831022024 Predicted transcriptional regulators [Transcription]; Region: COG1695 649831022025 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 649831022026 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 649831022027 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 649831022028 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 649831022029 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 649831022030 DNA binding site [nucleotide binding] 649831022031 active site 649831022032 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 649831022033 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 649831022034 active site 649831022035 NTP binding site [chemical binding]; other site 649831022036 metal binding triad [ion binding]; metal-binding site 649831022037 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 649831022038 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 649831022039 Zn2+ binding site [ion binding]; other site 649831022040 Mg2+ binding site [ion binding]; other site 649831022041 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 649831022042 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 649831022043 active site 649831022044 ATP binding site [chemical binding]; other site 649831022045 substrate binding site [chemical binding]; other site 649831022046 activation loop (A-loop); other site 649831022047 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 649831022048 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 649831022049 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 649831022050 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 649831022051 DNA binding residues [nucleotide binding] 649831022052 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 649831022053 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 649831022054 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 649831022055 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 649831022056 catalytic residues [active] 649831022057 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 649831022058 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 649831022059 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 649831022060 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 649831022061 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 649831022062 active site 649831022063 metal binding site [ion binding]; metal-binding site 649831022064 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 649831022065 Coenzyme A binding pocket [chemical binding]; other site 649831022066 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 649831022067 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 649831022068 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 649831022069 pyridoxal 5'-phosphate binding site [chemical binding]; other site 649831022070 homodimer interface [polypeptide binding]; other site 649831022071 catalytic residue [active] 649831022072 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 649831022073 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 649831022074 ATP-grasp domain; Region: ATP-grasp_4; cl17255 649831022075 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 649831022076 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 649831022077 ParB-like nuclease domain; Region: ParBc; pfam02195 649831022078 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 649831022079 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 649831022080 Magnesium ion binding site [ion binding]; other site 649831022081 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 649831022082 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 649831022083 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 649831022084 G-X-X-G motif; other site 649831022085 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 649831022086 RxxxH motif; other site 649831022087 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 649831022088 Haemolytic domain; Region: Haemolytic; pfam01809 649831022089 Ribonuclease P; Region: Ribonuclease_P; pfam00825 649831022090 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399