-- dump date 20140618_191703 -- class Genbank::misc_feature -- table misc_feature_note -- id note 134676000001 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 134676000002 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 134676000003 Walker A motif; other site 134676000004 ATP binding site [chemical binding]; other site 134676000005 Walker B motif; other site 134676000006 arginine finger; other site 134676000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 134676000008 DnaA box-binding interface [nucleotide binding]; other site 134676000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 134676000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 134676000011 putative DNA binding surface [nucleotide binding]; other site 134676000012 dimer interface [polypeptide binding]; other site 134676000013 beta-clamp/clamp loader binding surface; other site 134676000014 beta-clamp/translesion DNA polymerase binding surface; other site 134676000015 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 134676000016 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 134676000017 recombination protein F; Reviewed; Region: recF; PRK00064 134676000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 134676000019 Walker A/P-loop; other site 134676000020 ATP binding site [chemical binding]; other site 134676000021 Q-loop/lid; other site 134676000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 134676000023 ABC transporter signature motif; other site 134676000024 Walker B; other site 134676000025 D-loop; other site 134676000026 H-loop/switch region; other site 134676000027 Protein of unknown function (DUF721); Region: DUF721; cl02324 134676000028 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 134676000029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676000030 Mg2+ binding site [ion binding]; other site 134676000031 G-X-G motif; other site 134676000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 134676000033 anchoring element; other site 134676000034 dimer interface [polypeptide binding]; other site 134676000035 ATP binding site [chemical binding]; other site 134676000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 134676000037 active site 134676000038 putative metal-binding site [ion binding]; other site 134676000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 134676000040 DNA gyrase subunit A; Validated; Region: PRK05560 134676000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 134676000042 CAP-like domain; other site 134676000043 active site 134676000044 primary dimer interface [polypeptide binding]; other site 134676000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 134676000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 134676000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 134676000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 134676000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 134676000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 134676000051 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 134676000052 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 134676000053 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676000054 active site 134676000055 phosphorylation site [posttranslational modification] 134676000056 intermolecular recognition site; other site 134676000057 dimerization interface [polypeptide binding]; other site 134676000058 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 134676000059 DNA binding residues [nucleotide binding] 134676000060 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 134676000061 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676000062 ATP binding site [chemical binding]; other site 134676000063 Mg2+ binding site [ion binding]; other site 134676000064 G-X-G motif; other site 134676000065 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 134676000066 nudix motif; other site 134676000067 PA2301 is an uncharacterized Pseudomonas aeruginosa protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's...; Region: PA2301; cd04939 134676000068 putative deacylase active site [active] 134676000069 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 134676000070 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 134676000071 catalytic residues [active] 134676000072 Fe-S metabolism associated domain; Region: SufE; cl00951 134676000073 FOG: CBS domain [General function prediction only]; Region: COG0517 134676000074 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 134676000075 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 134676000076 active site 134676000077 catalytic triad [active] 134676000078 oxyanion hole [active] 134676000079 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 134676000080 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 134676000081 active site residue [active] 134676000082 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 134676000083 active site residue [active] 134676000084 HSP90 family protein; Provisional; Region: PRK14083 134676000085 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676000086 ATP binding site [chemical binding]; other site 134676000087 Mg2+ binding site [ion binding]; other site 134676000088 G-X-G motif; other site 134676000089 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 134676000090 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676000091 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 134676000092 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 134676000093 ATP-grasp domain; Region: ATP-grasp_4; cl17255 134676000094 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 134676000095 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 134676000096 active site 134676000097 catalytic residues [active] 134676000098 metal binding site [ion binding]; metal-binding site 134676000099 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07003 134676000100 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 134676000101 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 134676000102 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 134676000103 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 134676000104 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 134676000105 active site 134676000106 Predicted ATPase [General function prediction only]; Region: COG3903 134676000107 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 134676000108 MarR family; Region: MarR; pfam01047 134676000109 Uncharacterized conserved protein [Function unknown]; Region: COG2353 134676000110 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 134676000111 Domain of unknown function (DUF397); Region: DUF397; pfam04149 134676000112 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 134676000113 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 134676000114 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 134676000115 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 134676000116 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 134676000117 phosphopeptide binding site; other site 134676000118 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 134676000119 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 134676000120 phosphopeptide binding site; other site 134676000121 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 134676000122 active site 134676000123 BofC C-terminal domain; Region: BofC_C; pfam08955 134676000124 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 134676000125 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 134676000126 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 134676000127 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 134676000128 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 134676000129 active site 134676000130 ATP binding site [chemical binding]; other site 134676000131 substrate binding site [chemical binding]; other site 134676000132 activation loop (A-loop); other site 134676000133 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 134676000134 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 134676000135 active site 134676000136 ATP binding site [chemical binding]; other site 134676000137 substrate binding site [chemical binding]; other site 134676000138 activation loop (A-loop); other site 134676000139 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 134676000140 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 134676000141 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 134676000142 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 134676000143 Glutamine amidotransferase class-I; Region: GATase; pfam00117 134676000144 glutamine binding [chemical binding]; other site 134676000145 catalytic triad [active] 134676000146 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 134676000147 active site 134676000148 catalytic site [active] 134676000149 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 134676000150 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 134676000151 Uncharacterized protein family (UPF0233); Region: UPF0233; pfam06781 134676000152 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 134676000153 4Fe-4S binding domain; Region: Fer4; pfam00037 134676000154 Cysteine-rich domain; Region: CCG; pfam02754 134676000155 Cysteine-rich domain; Region: CCG; pfam02754 134676000156 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 134676000157 Domain of unknown function DUF21; Region: DUF21; pfam01595 134676000158 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 134676000159 Transporter associated domain; Region: CorC_HlyC; smart01091 134676000160 Domain of unknown function DUF21; Region: DUF21; pfam01595 134676000161 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 134676000162 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cd00110 134676000163 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 134676000164 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 134676000165 trimer interface [polypeptide binding]; other site 134676000166 active site 134676000167 YCII-related domain; Region: YCII; cl00999 134676000168 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 134676000169 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 134676000170 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 134676000171 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 134676000172 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 134676000173 active site 134676000174 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 134676000175 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 134676000176 catalytic core [active] 134676000177 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 134676000178 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 134676000179 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 134676000180 putative active site [active] 134676000181 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 134676000182 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 134676000183 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 134676000184 DNA binding residues [nucleotide binding] 134676000185 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 134676000186 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 134676000187 NHL repeat; Region: NHL; pfam01436 134676000188 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 134676000189 large tegument protein UL36; Provisional; Region: PHA03247 134676000190 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 134676000191 E3 interaction surface; other site 134676000192 lipoyl attachment site [posttranslational modification]; other site 134676000193 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 134676000194 e3 binding domain; Region: E3_binding; pfam02817 134676000195 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 134676000196 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 134676000197 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 134676000198 alpha subunit interface [polypeptide binding]; other site 134676000199 TPP binding site [chemical binding]; other site 134676000200 heterodimer interface [polypeptide binding]; other site 134676000201 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 134676000202 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 134676000203 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 134676000204 TPP-binding site [chemical binding]; other site 134676000205 tetramer interface [polypeptide binding]; other site 134676000206 heterodimer interface [polypeptide binding]; other site 134676000207 phosphorylation loop region [posttranslational modification] 134676000208 Dynamin family; Region: Dynamin_N; pfam00350 134676000209 YfjP GTPase; Region: YfjP; cd11383 134676000210 G1 box; other site 134676000211 GTP/Mg2+ binding site [chemical binding]; other site 134676000212 Switch I region; other site 134676000213 G2 box; other site 134676000214 Switch II region; other site 134676000215 G3 box; other site 134676000216 G4 box; other site 134676000217 G5 box; other site 134676000218 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 134676000219 GTP/Mg2+ binding site [chemical binding]; other site 134676000220 G5 box; other site 134676000221 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 134676000222 G1 box; other site 134676000223 G1 box; other site 134676000224 GTP/Mg2+ binding site [chemical binding]; other site 134676000225 G2 box; other site 134676000226 Switch I region; other site 134676000227 G3 box; other site 134676000228 Switch II region; other site 134676000229 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 134676000230 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 134676000231 nucleotide binding site [chemical binding]; other site 134676000232 NEF interaction site [polypeptide binding]; other site 134676000233 SBD interface [polypeptide binding]; other site 134676000234 heat shock protein GrpE; Provisional; Region: PRK14140 134676000235 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 134676000236 dimer interface [polypeptide binding]; other site 134676000237 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 134676000238 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 134676000239 HSP70 interaction site [polypeptide binding]; other site 134676000240 DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684 134676000241 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 134676000242 Zn binding sites [ion binding]; other site 134676000243 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 134676000244 dimer interface [polypeptide binding]; other site 134676000245 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 134676000246 DNA binding residues [nucleotide binding] 134676000247 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 134676000248 putative dimer interface [polypeptide binding]; other site 134676000249 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 134676000250 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 134676000251 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 134676000252 TrkA-C domain; Region: TrkA_C; pfam02080 134676000253 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 134676000254 sugar efflux transporter; Region: 2A0120; TIGR00899 134676000255 putative substrate translocation pore; other site 134676000256 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 134676000257 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 134676000258 Walker A motif; other site 134676000259 ATP binding site [chemical binding]; other site 134676000260 Walker B motif; other site 134676000261 arginine finger; other site 134676000262 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 134676000263 Walker A motif; other site 134676000264 ATP binding site [chemical binding]; other site 134676000265 Walker B motif; other site 134676000266 arginine finger; other site 134676000267 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 134676000268 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 134676000269 dimerization interface [polypeptide binding]; other site 134676000270 putative DNA binding site [nucleotide binding]; other site 134676000271 putative Zn2+ binding site [ion binding]; other site 134676000272 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases [Carbohydrate transport and metabolism]; Region: AraD; COG0235 134676000273 intersubunit interface [polypeptide binding]; other site 134676000274 active site 134676000275 Zn2+ binding site [ion binding]; other site 134676000276 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 134676000277 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 134676000278 polynucleotide kinase-phosphatase; Region: bacter_Pnkp; TIGR04075 134676000279 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 134676000280 active site 134676000281 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 134676000282 active site 134676000283 metal binding site [ion binding]; metal-binding site 134676000284 RNA repair, ligase-Pnkp-associating, region of Hen1; Region: Hen1_L; pfam12623 134676000285 3' terminal RNA ribose 2'-O-methyltransferase Hen1; Region: bacter_Hen1; TIGR04074 134676000286 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 134676000287 S-adenosylmethionine binding site [chemical binding]; other site 134676000288 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 134676000289 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 134676000290 active site 134676000291 intersubunit interface [polypeptide binding]; other site 134676000292 zinc binding site [ion binding]; other site 134676000293 Na+ binding site [ion binding]; other site 134676000294 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 134676000295 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 134676000296 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 134676000297 putative lipid kinase; Reviewed; Region: PRK13057 134676000298 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 134676000299 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 134676000300 GDP-binding site [chemical binding]; other site 134676000301 ACT binding site; other site 134676000302 IMP binding site; other site 134676000303 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 134676000304 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 134676000305 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 134676000306 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 134676000307 SCP-2 sterol transfer family; Region: SCP2; pfam02036 134676000308 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 134676000309 dimerization interface [polypeptide binding]; other site 134676000310 putative DNA binding site [nucleotide binding]; other site 134676000311 putative Zn2+ binding site [ion binding]; other site 134676000312 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 134676000313 adenylosuccinate lyase; Region: purB; TIGR00928 134676000314 tetramer interface [polypeptide binding]; other site 134676000315 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 134676000316 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 134676000317 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 134676000318 putative active site [active] 134676000319 catalytic triad [active] 134676000320 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 134676000321 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 134676000322 dimerization interface [polypeptide binding]; other site 134676000323 ATP binding site [chemical binding]; other site 134676000324 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 134676000325 dimerization interface [polypeptide binding]; other site 134676000326 ATP binding site [chemical binding]; other site 134676000327 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 134676000328 amidophosphoribosyltransferase; Provisional; Region: PRK07847 134676000329 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 134676000330 active site 134676000331 tetramer interface [polypeptide binding]; other site 134676000332 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 134676000333 active site 134676000334 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 134676000335 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 134676000336 dimerization interface [polypeptide binding]; other site 134676000337 putative ATP binding site [chemical binding]; other site 134676000338 radical SAM/SPASM domain protein, GRRM system; Region: rSAM_GlyRichRpt; TIGR04261 134676000339 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 134676000340 FeS/SAM binding site; other site 134676000341 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 134676000342 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 134676000343 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 134676000344 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 134676000345 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 134676000346 NAD binding site [chemical binding]; other site 134676000347 Phe binding site; other site 134676000348 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 134676000349 DNA binding residues [nucleotide binding] 134676000350 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 134676000351 S-adenosylmethionine binding site [chemical binding]; other site 134676000352 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 134676000353 RNA 2'-phosphotransferase, Tpt1 / KptA family; Region: PTS_2-RNA; pfam01885 134676000354 Protease prsW family; Region: PrsW-protease; pfam13367 134676000355 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 134676000356 CoenzymeA binding site [chemical binding]; other site 134676000357 subunit interaction site [polypeptide binding]; other site 134676000358 PHB binding site; other site 134676000359 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 134676000360 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 134676000361 DNA binding residues [nucleotide binding] 134676000362 B12 binding domain; Region: B12-binding_2; pfam02607 134676000363 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 134676000364 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 134676000365 active site 134676000366 metal binding site [ion binding]; metal-binding site 134676000367 nudix motif; other site 134676000368 phytoene desaturase; Region: crtI_fam; TIGR02734 134676000369 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 134676000370 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 134676000371 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 134676000372 substrate binding pocket [chemical binding]; other site 134676000373 chain length determination region; other site 134676000374 substrate-Mg2+ binding site; other site 134676000375 catalytic residues [active] 134676000376 aspartate-rich region 1; other site 134676000377 active site lid residues [active] 134676000378 aspartate-rich region 2; other site 134676000379 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 134676000380 active site lid residues [active] 134676000381 substrate binding pocket [chemical binding]; other site 134676000382 catalytic residues [active] 134676000383 substrate-Mg2+ binding site; other site 134676000384 aspartate-rich region 1; other site 134676000385 aspartate-rich region 2; other site 134676000386 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 134676000387 DNA photolyase; Region: DNA_photolyase; pfam00875 134676000388 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 134676000389 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 134676000390 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 134676000391 Phytase; Region: Phytase; cl17685 134676000392 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 134676000393 Catalytic domain of Protein Kinases; Region: PKc; cd00180 134676000394 active site 134676000395 ATP binding site [chemical binding]; other site 134676000396 substrate binding site [chemical binding]; other site 134676000397 activation loop (A-loop); other site 134676000398 RNA polymerase sigma factor SigY; Reviewed; Region: PRK09638 134676000399 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 134676000400 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 134676000401 DNA binding residues [nucleotide binding] 134676000402 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 134676000403 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 134676000404 Int/Topo IB signature motif; other site 134676000405 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 134676000406 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 134676000407 intersubunit interface [polypeptide binding]; other site 134676000408 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 134676000409 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 134676000410 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 134676000411 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 134676000412 ABC-ATPase subunit interface; other site 134676000413 dimer interface [polypeptide binding]; other site 134676000414 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 134676000415 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 134676000416 Predicted permease; Region: DUF318; cl17795 134676000417 TIGR03943 family protein; Region: TIGR03943 134676000418 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 134676000419 active site 134676000420 Nicotianamine synthase protein; Region: NAS; cl17658 134676000421 YibE/F-like protein; Region: YibE_F; pfam07907 134676000422 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 134676000423 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 134676000424 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 134676000425 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 134676000426 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 134676000427 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 134676000428 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 134676000429 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 134676000430 Int/Topo IB signature motif; other site 134676000431 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 134676000432 active site 134676000433 catalytic residues [active] 134676000434 DNA binding site [nucleotide binding] 134676000435 Int/Topo IB signature motif; other site 134676000436 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 134676000437 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 134676000438 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 134676000439 DDE superfamily endonuclease; Region: DDE_4; cl17710 134676000440 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 134676000441 active site 134676000442 catalytic residues [active] 134676000443 DNA binding site [nucleotide binding] 134676000444 Int/Topo IB signature motif; other site 134676000445 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 134676000446 DNA binding site [nucleotide binding] 134676000447 active site 134676000448 Int/Topo IB signature motif; other site 134676000449 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 134676000450 Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706 134676000451 GAF domain; Region: GAF_2; pfam13185 134676000452 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 134676000453 PAS domain; Region: PAS_9; pfam13426 134676000454 putative active site [active] 134676000455 heme pocket [chemical binding]; other site 134676000456 GAF domain; Region: GAF_2; pfam13185 134676000457 GAF domain; Region: GAF; cl17456 134676000458 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 134676000459 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 134676000460 dimer interface [polypeptide binding]; other site 134676000461 phosphorylation site [posttranslational modification] 134676000462 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676000463 ATP binding site [chemical binding]; other site 134676000464 Mg2+ binding site [ion binding]; other site 134676000465 G-X-G motif; other site 134676000466 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 134676000467 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 134676000468 anti sigma factor interaction site; other site 134676000469 regulatory phosphorylation site [posttranslational modification]; other site 134676000470 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 134676000471 anti sigma factor interaction site; other site 134676000472 regulatory phosphorylation site [posttranslational modification]; other site 134676000473 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 134676000474 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676000475 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 134676000476 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 134676000477 FMN binding site [chemical binding]; other site 134676000478 active site 134676000479 substrate binding site [chemical binding]; other site 134676000480 catalytic residue [active] 134676000481 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 134676000482 Domain of unknown function (DUF4360); Region: DUF4360; pfam14273 134676000483 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 134676000484 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 134676000485 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 134676000486 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 134676000487 Transposase, Mutator family; Region: Transposase_mut; pfam00872 134676000488 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 134676000489 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 134676000490 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 134676000491 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 134676000492 Walker A/P-loop; other site 134676000493 ATP binding site [chemical binding]; other site 134676000494 Q-loop/lid; other site 134676000495 ABC transporter signature motif; other site 134676000496 Walker B; other site 134676000497 D-loop; other site 134676000498 H-loop/switch region; other site 134676000499 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 134676000500 PAP2 superfamily; Region: PAP2; pfam01569 134676000501 active site 134676000502 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 134676000503 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676000504 active site 134676000505 phosphorylation site [posttranslational modification] 134676000506 intermolecular recognition site; other site 134676000507 dimerization interface [polypeptide binding]; other site 134676000508 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 134676000509 DNA binding site [nucleotide binding] 134676000510 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 134676000511 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 134676000512 dimerization interface [polypeptide binding]; other site 134676000513 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 134676000514 dimer interface [polypeptide binding]; other site 134676000515 phosphorylation site [posttranslational modification] 134676000516 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676000517 ATP binding site [chemical binding]; other site 134676000518 Mg2+ binding site [ion binding]; other site 134676000519 G-X-G motif; other site 134676000520 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 134676000521 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 134676000522 DNA binding residues [nucleotide binding] 134676000523 dimer interface [polypeptide binding]; other site 134676000524 hypothetical protein; Provisional; Region: PRK08317 134676000525 Methyltransferase domain; Region: Methyltransf_11; pfam08241 134676000526 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 134676000527 NlpC/P60 family; Region: NLPC_P60; pfam00877 134676000528 Peptidase family M23; Region: Peptidase_M23; pfam01551 134676000529 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 134676000530 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 134676000531 Major Facilitator Superfamily; Region: MFS_1; pfam07690 134676000532 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 134676000533 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 134676000534 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 134676000535 dimer interface [polypeptide binding]; other site 134676000536 pyridoxal 5'-phosphate binding site [chemical binding]; other site 134676000537 catalytic residue [active] 134676000538 Domain of unknown function (DUF305); Region: DUF305; pfam03713 134676000539 Domain of unknown function (DUF305); Region: DUF305; pfam03713 134676000540 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 134676000541 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 134676000542 Int/Topo IB signature motif; other site 134676000543 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 134676000544 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 134676000545 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 134676000546 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 134676000547 putative sugar binding sites [chemical binding]; other site 134676000548 Q-X-W motif; other site 134676000549 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 134676000550 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 134676000551 putative sugar binding sites [chemical binding]; other site 134676000552 Q-X-W motif; other site 134676000553 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 134676000554 protein-splicing catalytic site; other site 134676000555 thioester formation/cholesterol transfer; other site 134676000556 SCP1.201-like deaminase; Region: SCP1201-deam; pfam14428 134676000557 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 134676000558 Predicted RNA binding protein (dsRBD-like fold), HicA family [General function prediction only]; Region: COG1724 134676000559 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 134676000560 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 134676000561 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 134676000562 putative sugar binding sites [chemical binding]; other site 134676000563 Q-X-W motif; other site 134676000564 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 134676000565 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 134676000566 sugar binding site [chemical binding]; other site 134676000567 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 134676000568 RHS Repeat; Region: RHS_repeat; cl11982 134676000569 RHS Repeat; Region: RHS_repeat; pfam05593 134676000570 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 134676000571 RHS Repeat; Region: RHS_repeat; pfam05593 134676000572 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 134676000573 Hint (Hedgehog/Intein) domain N-terminal region; Region: HintN; smart00306 134676000574 Pretoxin HINT domain; Region: PT-HINT; pfam07591 134676000575 Xanthomonas XOO_2897-like deaminase; Region: XOO_2897-deam; pfam14440 134676000576 heparan sulfate-N-deacetylase; Region: HSNSD; pfam12062 134676000577 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 134676000578 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 134676000579 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 134676000580 NAD dependent epimerase/dehydratase, LLPSF_EDH_00030 family; Region: EDH_00030; TIGR04180 134676000581 NAD binding site [chemical binding]; other site 134676000582 substrate binding site [chemical binding]; other site 134676000583 active site 134676000584 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 134676000585 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 134676000586 active site 134676000587 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 134676000588 extended (e) SDRs; Region: SDR_e; cd08946 134676000589 NAD(P) binding site [chemical binding]; other site 134676000590 active site 134676000591 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 134676000592 substrate binding site [chemical binding]; other site 134676000593 active site 134676000594 Spherulation-specific family 4; Region: Spherulin4; pfam12138 134676000595 TM1410 hypothetical-related protein; Region: DUF297; pfam03537 134676000596 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 134676000597 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 134676000598 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 134676000599 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 134676000600 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 134676000601 Mg2+ binding site [ion binding]; other site 134676000602 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 134676000603 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 134676000604 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 134676000605 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 134676000606 DNA binding residues [nucleotide binding] 134676000607 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 134676000608 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 134676000609 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 134676000610 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 134676000611 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 134676000612 pyridoxal 5'-phosphate binding site [chemical binding]; other site 134676000613 homodimer interface [polypeptide binding]; other site 134676000614 catalytic residue [active] 134676000615 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 134676000616 Fatty acid desaturase; Region: FA_desaturase; pfam00487 134676000617 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 134676000618 putative di-iron ligands [ion binding]; other site 134676000619 Biofilm formation and stress response factor; Region: BsmA; pfam10014 134676000620 substrate binding pocket [chemical binding]; other site 134676000621 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 134676000622 active site 134676000623 iron coordination sites [ion binding]; other site 134676000624 Major Facilitator Superfamily; Region: MFS_1; pfam07690 134676000625 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 134676000626 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 134676000627 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 134676000628 active site 134676000629 dimer interface [polypeptide binding]; other site 134676000630 motif 1; other site 134676000631 motif 2; other site 134676000632 motif 3; other site 134676000633 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 134676000634 anticodon binding site; other site 134676000635 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 134676000636 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 134676000637 Walker A/P-loop; other site 134676000638 ATP binding site [chemical binding]; other site 134676000639 Q-loop/lid; other site 134676000640 ABC transporter signature motif; other site 134676000641 Walker B; other site 134676000642 D-loop; other site 134676000643 H-loop/switch region; other site 134676000644 Predicted transcriptional regulators [Transcription]; Region: COG1695 134676000645 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 134676000646 FlgD Ig-like domain; Region: FlgD_ig; pfam13860 134676000647 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 134676000648 Family description; Region: VCBS; pfam13517 134676000649 Family description; Region: VCBS; pfam13517 134676000650 Response regulator receiver domain; Region: Response_reg; pfam00072 134676000651 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676000652 active site 134676000653 phosphorylation site [posttranslational modification] 134676000654 intermolecular recognition site; other site 134676000655 dimerization interface [polypeptide binding]; other site 134676000656 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 134676000657 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 134676000658 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 134676000659 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 134676000660 dimer interface [polypeptide binding]; other site 134676000661 phosphorylation site [posttranslational modification] 134676000662 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676000663 ATP binding site [chemical binding]; other site 134676000664 Mg2+ binding site [ion binding]; other site 134676000665 G-X-G motif; other site 134676000666 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 134676000667 ATP binding site [chemical binding]; other site 134676000668 Mg2+ binding site [ion binding]; other site 134676000669 G-X-G motif; other site 134676000670 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 134676000671 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 134676000672 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 134676000673 RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361 134676000674 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 134676000675 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 134676000676 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 134676000677 anti sigma factor interaction site; other site 134676000678 regulatory phosphorylation site [posttranslational modification]; other site 134676000679 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 134676000680 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 134676000681 Putative zinc-finger; Region: zf-HC2; pfam13490 134676000682 Predicted integral membrane protein [Function unknown]; Region: COG5660 134676000683 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 134676000684 CGNR zinc finger; Region: zf-CGNR; pfam11706 134676000685 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 134676000686 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 134676000687 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 134676000688 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 134676000689 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 134676000690 FAD binding domain; Region: FAD_binding_4; pfam01565 134676000691 RibD C-terminal domain; Region: RibD_C; cl17279 134676000692 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 134676000693 RibD C-terminal domain; Region: RibD_C; cl17279 134676000694 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 134676000695 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 134676000696 GAF domain; Region: GAF; cl17456 134676000697 GAF domain; Region: GAF_2; pfam13185 134676000698 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 134676000699 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 134676000700 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 134676000701 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 134676000702 dimerization interface [polypeptide binding]; other site 134676000703 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 134676000704 dimerization interface [polypeptide binding]; other site 134676000705 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 134676000706 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 134676000707 dimerization interface [polypeptide binding]; other site 134676000708 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 134676000709 dimerization interface [polypeptide binding]; other site 134676000710 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 134676000711 dimerization interface [polypeptide binding]; other site 134676000712 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 134676000713 dimerization interface [polypeptide binding]; other site 134676000714 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 134676000715 dimerization interface [polypeptide binding]; other site 134676000716 GAF domain; Region: GAF_2; pfam13185 134676000717 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 134676000718 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 134676000719 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676000720 ATP binding site [chemical binding]; other site 134676000721 Mg2+ binding site [ion binding]; other site 134676000722 G-X-G motif; other site 134676000723 Response regulator receiver domain; Region: Response_reg; pfam00072 134676000724 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676000725 active site 134676000726 phosphorylation site [posttranslational modification] 134676000727 intermolecular recognition site; other site 134676000728 dimerization interface [polypeptide binding]; other site 134676000729 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676000730 Response regulator receiver domain; Region: Response_reg; pfam00072 134676000731 active site 134676000732 phosphorylation site [posttranslational modification] 134676000733 intermolecular recognition site; other site 134676000734 dimerization interface [polypeptide binding]; other site 134676000735 Pectate lyase; Region: Pectate_lyase; pfam03211 134676000736 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 134676000737 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 134676000738 DNA binding residues [nucleotide binding] 134676000739 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 134676000740 anti sigma factor interaction site; other site 134676000741 regulatory phosphorylation site [posttranslational modification]; other site 134676000742 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 134676000743 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 134676000744 inhibitor-cofactor binding pocket; inhibition site 134676000745 pyridoxal 5'-phosphate binding site [chemical binding]; other site 134676000746 catalytic residue [active] 134676000747 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 134676000748 catalytic core [active] 134676000749 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 134676000750 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 134676000751 catalytic residues [active] 134676000752 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 134676000753 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 134676000754 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 134676000755 ResB-like family; Region: ResB; pfam05140 134676000756 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 134676000757 menaquinone biosynthesis decarboxylase, SCO4490 family; Region: mena_SCO4490; TIGR03701 134676000758 prenyltransferase; Reviewed; Region: ubiA; PRK12888 134676000759 UbiA prenyltransferase family; Region: UbiA; pfam01040 134676000760 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 134676000761 Flavoprotein; Region: Flavoprotein; pfam02441 134676000762 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 134676000763 DNA binding residues [nucleotide binding] 134676000764 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 134676000765 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 134676000766 putative DNA binding site [nucleotide binding]; other site 134676000767 putative Zn2+ binding site [ion binding]; other site 134676000768 AsnC family; Region: AsnC_trans_reg; pfam01037 134676000769 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 134676000770 Putative glycolipid-binding; Region: Glycolipid_bind; pfam06475 134676000771 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 134676000772 DEAD-like helicases superfamily; Region: DEXDc; smart00487 134676000773 ATP binding site [chemical binding]; other site 134676000774 Mg++ binding site [ion binding]; other site 134676000775 motif III; other site 134676000776 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 134676000777 nucleotide binding region [chemical binding]; other site 134676000778 ATP-binding site [chemical binding]; other site 134676000779 cell division protein ZipA; Provisional; Region: PRK03427 134676000780 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 134676000781 NlpC/P60 family; Region: NLPC_P60; pfam00877 134676000782 putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700 134676000783 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 134676000784 FeS/SAM binding site; other site 134676000785 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 134676000786 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 134676000787 putative binding site residues; other site 134676000788 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 134676000789 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 134676000790 dimer interface [polypeptide binding]; other site 134676000791 putative PBP binding regions; other site 134676000792 ABC-ATPase subunit interface; other site 134676000793 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 134676000794 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 134676000795 Walker A/P-loop; other site 134676000796 ATP binding site [chemical binding]; other site 134676000797 Q-loop/lid; other site 134676000798 ABC transporter signature motif; other site 134676000799 Walker B; other site 134676000800 D-loop; other site 134676000801 H-loop/switch region; other site 134676000802 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 134676000803 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 134676000804 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 134676000805 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 134676000806 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 134676000807 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 134676000808 Uncharacterized protein conserved in bacteria (DUF2336); Region: DUF2336; pfam10098 134676000809 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 134676000810 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 134676000811 Part of AAA domain; Region: AAA_19; pfam13245 134676000812 Family description; Region: UvrD_C_2; pfam13538 134676000813 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 134676000814 dimerization interface [polypeptide binding]; other site 134676000815 putative DNA binding site [nucleotide binding]; other site 134676000816 putative Zn2+ binding site [ion binding]; other site 134676000817 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 134676000818 putative substrate translocation pore; other site 134676000819 Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621 134676000820 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 134676000821 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 134676000822 active site 134676000823 catalytic tetrad [active] 134676000824 Uncharacterized conserved protein [Function unknown]; Region: COG4279 134676000825 SWIM zinc finger; Region: SWIM; pfam04434 134676000826 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 134676000827 SNF2 Helicase protein; Region: DUF3670; pfam12419 134676000828 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 134676000829 ATP binding site [chemical binding]; other site 134676000830 putative Mg++ binding site [ion binding]; other site 134676000831 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 134676000832 nucleotide binding region [chemical binding]; other site 134676000833 ATP-binding site [chemical binding]; other site 134676000834 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359 134676000835 putative dimer interface [polypeptide binding]; other site 134676000836 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 134676000837 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 134676000838 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676000839 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 134676000840 menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699 134676000841 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 134676000842 FeS/SAM binding site; other site 134676000843 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 134676000844 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 134676000845 S-adenosylmethionine binding site [chemical binding]; other site 134676000846 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 134676000847 NADH dehydrogenase subunit A; Validated; Region: PRK07928 134676000848 NADH dehydrogenase subunit B; Validated; Region: PRK06411 134676000849 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 134676000850 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 134676000851 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 134676000852 NADH dehydrogenase subunit D; Validated; Region: PRK06075 134676000853 NADH dehydrogenase subunit E; Validated; Region: PRK07539 134676000854 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 134676000855 putative dimer interface [polypeptide binding]; other site 134676000856 [2Fe-2S] cluster binding site [ion binding]; other site 134676000857 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 134676000858 SLBB domain; Region: SLBB; pfam10531 134676000859 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 134676000860 NADH dehydrogenase subunit G; Validated; Region: PRK07860 134676000861 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 134676000862 catalytic loop [active] 134676000863 iron binding site [ion binding]; other site 134676000864 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 134676000865 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 134676000866 molybdopterin cofactor binding site; other site 134676000867 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 134676000868 molybdopterin cofactor binding site; other site 134676000869 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 134676000870 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 134676000871 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 134676000872 4Fe-4S binding domain; Region: Fer4; pfam00037 134676000873 4Fe-4S binding domain; Region: Fer4; pfam00037 134676000874 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 134676000875 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 134676000876 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 134676000877 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 134676000878 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 134676000879 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 134676000880 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 134676000881 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 134676000882 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 134676000883 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 134676000884 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 134676000885 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 134676000886 substrate binding pocket [chemical binding]; other site 134676000887 chain length determination region; other site 134676000888 substrate-Mg2+ binding site; other site 134676000889 catalytic residues [active] 134676000890 aspartate-rich region 1; other site 134676000891 active site lid residues [active] 134676000892 aspartate-rich region 2; other site 134676000893 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 134676000894 Putative zinc-finger; Region: zf-HC2; pfam13490 134676000895 Predicted permeases [General function prediction only]; Region: RarD; COG2962 134676000896 Predicted membrane protein [Function unknown]; Region: COG1950 134676000897 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 134676000898 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 134676000899 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 134676000900 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 134676000901 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 134676000902 acetyl-CoA synthetase; Provisional; Region: PRK00174 134676000903 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 134676000904 active site 134676000905 CoA binding site [chemical binding]; other site 134676000906 acyl-activating enzyme (AAE) consensus motif; other site 134676000907 AMP binding site [chemical binding]; other site 134676000908 acetate binding site [chemical binding]; other site 134676000909 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 134676000910 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 134676000911 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 134676000912 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 134676000913 anti sigma factor interaction site; other site 134676000914 regulatory phosphorylation site [posttranslational modification]; other site 134676000915 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 134676000916 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 134676000917 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 134676000918 ATP binding site [chemical binding]; other site 134676000919 Walker B motif; other site 134676000920 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 134676000921 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 134676000922 ATP binding site [chemical binding]; other site 134676000923 putative Mg++ binding site [ion binding]; other site 134676000924 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 134676000925 helicase superfamily c-terminal domain; Region: HELICc; smart00490 134676000926 nucleotide binding region [chemical binding]; other site 134676000927 ATP-binding site [chemical binding]; other site 134676000928 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 134676000929 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 134676000930 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 134676000931 anti sigma factor interaction site; other site 134676000932 regulatory phosphorylation site [posttranslational modification]; other site 134676000933 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 134676000934 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 134676000935 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 134676000936 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 134676000937 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 134676000938 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 134676000939 active site 134676000940 interdomain interaction site; other site 134676000941 putative metal-binding site [ion binding]; other site 134676000942 nucleotide binding site [chemical binding]; other site 134676000943 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 134676000944 domain I; other site 134676000945 phosphate binding site [ion binding]; other site 134676000946 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 134676000947 domain II; other site 134676000948 domain III; other site 134676000949 nucleotide binding site [chemical binding]; other site 134676000950 DNA binding groove [nucleotide binding] 134676000951 catalytic site [active] 134676000952 domain IV; other site 134676000953 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 134676000954 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 134676000955 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 134676000956 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 134676000957 FAD binding domain; Region: FAD_binding_4; pfam01565 134676000958 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 134676000959 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 134676000960 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676000961 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 134676000962 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 134676000963 dimer interface [polypeptide binding]; other site 134676000964 active site 134676000965 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 134676000966 substrate binding site [chemical binding]; other site 134676000967 catalytic residue [active] 134676000968 H+ Antiporter protein; Region: 2A0121; TIGR00900 134676000969 thymidylate kinase; Validated; Region: tmk; PRK00698 134676000970 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 134676000971 TMP-binding site; other site 134676000972 ATP-binding site [chemical binding]; other site 134676000973 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 134676000974 DNA polymerase III subunit delta'; Validated; Region: PRK07940 134676000975 DNA polymerase III subunit delta'; Validated; Region: PRK08485 134676000976 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 134676000977 PSP1 C-terminal conserved region; Region: PSP1; cl00770 134676000978 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 134676000979 Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487 134676000980 active site 134676000981 catalytic triad [active] 134676000982 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 134676000983 protein-splicing catalytic site; other site 134676000984 thioester formation/cholesterol transfer; other site 134676000985 Pretoxin HINT domain; Region: PT-HINT; pfam07591 134676000986 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 134676000987 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 134676000988 Domain of unknown function (DUF397); Region: DUF397; pfam04149 134676000989 Domain of unknown function (DUF397); Region: DUF397; pfam04149 134676000990 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 134676000991 sequence-specific DNA binding site [nucleotide binding]; other site 134676000992 salt bridge; other site 134676000993 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 134676000994 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 134676000995 sequence-specific DNA binding site [nucleotide binding]; other site 134676000996 salt bridge; other site 134676000997 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 134676000998 nucleotide binding site [chemical binding]; other site 134676000999 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 134676001000 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 134676001001 active site 134676001002 DNA binding site [nucleotide binding] 134676001003 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 134676001004 DNA binding site [nucleotide binding] 134676001005 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 134676001006 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 134676001007 putative DNA binding site [nucleotide binding]; other site 134676001008 putative homodimer interface [polypeptide binding]; other site 134676001009 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 134676001010 nudix motif; other site 134676001011 enterobactin exporter EntS; Provisional; Region: PRK10489 134676001012 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 134676001013 putative substrate translocation pore; other site 134676001014 Predicted transcriptional regulators [Transcription]; Region: COG1695 134676001015 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 134676001016 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 134676001017 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 134676001018 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 134676001019 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 134676001020 ATP binding site [chemical binding]; other site 134676001021 putative Mg++ binding site [ion binding]; other site 134676001022 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 134676001023 nucleotide binding region [chemical binding]; other site 134676001024 ATP-binding site [chemical binding]; other site 134676001025 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 134676001026 WYL domain; Region: WYL; pfam13280 134676001027 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 134676001028 DNA-binding site [nucleotide binding]; DNA binding site 134676001029 RNA-binding motif; other site 134676001030 Menaquinone biosynthesis; Region: VitK2_biosynth; cl17475 134676001031 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 134676001032 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 134676001033 beta-galactosidase; Region: BGL; TIGR03356 134676001034 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 134676001035 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676001036 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 134676001037 Major Facilitator Superfamily; Region: MFS_1; pfam07690 134676001038 hypothetical protein; Provisional; Region: PRK08236 134676001039 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 134676001040 Major Facilitator Superfamily; Region: MFS_1; pfam07690 134676001041 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 134676001042 H+ Antiporter protein; Region: 2A0121; TIGR00900 134676001043 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 134676001044 putative Zn2+ binding site [ion binding]; other site 134676001045 putative DNA binding site [nucleotide binding]; other site 134676001046 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 134676001047 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 134676001048 MarR family; Region: MarR; pfam01047 134676001049 H+ Antiporter protein; Region: 2A0121; TIGR00900 134676001050 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 134676001051 putative substrate translocation pore; other site 134676001052 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 134676001053 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 134676001054 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 134676001055 phosphoserine aminotransferase; Provisional; Region: PRK03080 134676001056 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 134676001057 catalytic residue [active] 134676001058 citrate synthase 2; Provisional; Region: PRK12350 134676001059 Citrate synthase; Region: Citrate_synt; pfam00285 134676001060 oxalacetate binding site [chemical binding]; other site 134676001061 citrylCoA binding site [chemical binding]; other site 134676001062 coenzyme A binding site [chemical binding]; other site 134676001063 catalytic triad [active] 134676001064 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 134676001065 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 134676001066 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 134676001067 enterobactin exporter EntS; Provisional; Region: PRK10489 134676001068 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 134676001069 active site 134676001070 catalytic residues [active] 134676001071 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 134676001072 putative FMN binding site [chemical binding]; other site 134676001073 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 134676001074 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 134676001075 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 134676001076 active site 134676001077 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 134676001078 PspC domain; Region: PspC; pfam04024 134676001079 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 134676001080 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 134676001081 Walker A/P-loop; other site 134676001082 ATP binding site [chemical binding]; other site 134676001083 Q-loop/lid; other site 134676001084 ABC transporter signature motif; other site 134676001085 Walker B; other site 134676001086 D-loop; other site 134676001087 H-loop/switch region; other site 134676001088 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 134676001089 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 134676001090 ATP binding site [chemical binding]; other site 134676001091 Mg2+ binding site [ion binding]; other site 134676001092 G-X-G motif; other site 134676001093 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 134676001094 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 134676001095 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 134676001096 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 134676001097 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 134676001098 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 134676001099 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 134676001100 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 134676001101 Walker A/P-loop; other site 134676001102 ATP binding site [chemical binding]; other site 134676001103 Q-loop/lid; other site 134676001104 ABC transporter signature motif; other site 134676001105 Walker B; other site 134676001106 D-loop; other site 134676001107 H-loop/switch region; other site 134676001108 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 134676001109 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 134676001110 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 134676001111 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676001112 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 134676001113 nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526 134676001114 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 134676001115 active site 134676001116 nucleotide binding site [chemical binding]; other site 134676001117 HIGH motif; other site 134676001118 KMSKS motif; other site 134676001119 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 134676001120 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 134676001121 Major Facilitator Superfamily; Region: MFS_1; pfam07690 134676001122 putative substrate translocation pore; other site 134676001123 tetracycline repressor protein TetR; Provisional; Region: PRK13756 134676001124 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676001125 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 134676001126 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 134676001127 active site residue [active] 134676001128 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 134676001129 Domain of unknown function (DUF239); Region: DUF239; pfam03080 134676001130 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 134676001131 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 134676001132 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 134676001133 DNA binding residues [nucleotide binding] 134676001134 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 134676001135 putative dimer interface [polypeptide binding]; other site 134676001136 catalytic triad [active] 134676001137 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 134676001138 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 134676001139 putative substrate translocation pore; other site 134676001140 Response regulator receiver domain; Region: Response_reg; pfam00072 134676001141 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676001142 active site 134676001143 phosphorylation site [posttranslational modification] 134676001144 intermolecular recognition site; other site 134676001145 dimerization interface [polypeptide binding]; other site 134676001146 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 134676001147 Zeta-crystallin with NADP-dependent quinone reductase activity (QOR); Region: zeta_crystallin; cd08253 134676001148 NAD(P) binding site [chemical binding]; other site 134676001149 Putative sensor; Region: Sensor; pfam13796 134676001150 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 134676001151 Histidine kinase; Region: HisKA_3; pfam07730 134676001152 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676001153 ATP binding site [chemical binding]; other site 134676001154 Mg2+ binding site [ion binding]; other site 134676001155 G-X-G motif; other site 134676001156 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 134676001157 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676001158 active site 134676001159 phosphorylation site [posttranslational modification] 134676001160 intermolecular recognition site; other site 134676001161 dimerization interface [polypeptide binding]; other site 134676001162 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 134676001163 dimerization interface [polypeptide binding]; other site 134676001164 DNA binding residues [nucleotide binding] 134676001165 MMPL family; Region: MMPL; pfam03176 134676001166 MMPL family; Region: MMPL; pfam03176 134676001167 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 134676001168 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 134676001169 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 134676001170 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 134676001171 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 134676001172 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676001173 metal binding site [ion binding]; metal-binding site 134676001174 active site 134676001175 I-site; other site 134676001176 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 134676001177 amino acid transporter; Region: 2A0306; TIGR00909 134676001178 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 134676001179 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 134676001180 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 134676001181 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676001182 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 134676001183 TAP-like protein; Region: Abhydrolase_4; pfam08386 134676001184 Predicted membrane protein [Function unknown]; Region: COG2119 134676001185 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 134676001186 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 134676001187 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 134676001188 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 134676001189 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 134676001190 binding surface 134676001191 TPR motif; other site 134676001192 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 134676001193 putative substrate translocation pore; other site 134676001194 MarR family; Region: MarR_2; cl17246 134676001195 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 134676001196 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 134676001197 Glyco_18 domain; Region: Glyco_18; smart00636 134676001198 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 134676001199 active site 134676001200 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 134676001201 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 134676001202 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 134676001203 NAD(P) binding site [chemical binding]; other site 134676001204 active site 134676001205 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 134676001206 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 134676001207 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 134676001208 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 134676001209 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 134676001210 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 134676001211 DNA binding residues [nucleotide binding] 134676001212 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 134676001213 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 134676001214 ATP binding site [chemical binding]; other site 134676001215 Mg2+ binding site [ion binding]; other site 134676001216 G-X-G motif; other site 134676001217 serine hydroxymethyltransferase; Provisional; Region: PRK13580 134676001218 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 134676001219 dimer interface [polypeptide binding]; other site 134676001220 active site 134676001221 glycine-pyridoxal phosphate binding site [chemical binding]; other site 134676001222 folate binding site [chemical binding]; other site 134676001223 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 134676001224 sugar binding site [chemical binding]; other site 134676001225 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 134676001226 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 134676001227 ligand binding site [chemical binding]; other site 134676001228 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 134676001229 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 134676001230 TM-ABC transporter signature motif; other site 134676001231 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 134676001232 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 134676001233 Walker A/P-loop; other site 134676001234 ATP binding site [chemical binding]; other site 134676001235 Q-loop/lid; other site 134676001236 ABC transporter signature motif; other site 134676001237 Walker B; other site 134676001238 D-loop; other site 134676001239 H-loop/switch region; other site 134676001240 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 134676001241 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676001242 metal binding site [ion binding]; metal-binding site 134676001243 active site 134676001244 I-site; other site 134676001245 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 134676001246 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 134676001247 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 134676001248 substrate binding pocket [chemical binding]; other site 134676001249 membrane-bound complex binding site; other site 134676001250 hinge residues; other site 134676001251 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 134676001252 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676001253 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 134676001254 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 134676001255 Walker A/P-loop; other site 134676001256 ATP binding site [chemical binding]; other site 134676001257 Q-loop/lid; other site 134676001258 ABC transporter signature motif; other site 134676001259 Walker B; other site 134676001260 D-loop; other site 134676001261 H-loop/switch region; other site 134676001262 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 134676001263 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 134676001264 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 134676001265 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 134676001266 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 134676001267 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 134676001268 Adenosylhomocysteinase; Provisional; Region: PTZ00075 134676001269 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 134676001270 homotetramer interface [polypeptide binding]; other site 134676001271 ligand binding site [chemical binding]; other site 134676001272 catalytic site [active] 134676001273 NAD binding site [chemical binding]; other site 134676001274 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 134676001275 DNA binding site [nucleotide binding] 134676001276 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 134676001277 YCII-related domain; Region: YCII; cl00999 134676001278 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 134676001279 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 134676001280 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 134676001281 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 134676001282 dimerization interface [polypeptide binding]; other site 134676001283 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 134676001284 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 134676001285 dimer interface [polypeptide binding]; other site 134676001286 putative CheW interface [polypeptide binding]; other site 134676001287 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 134676001288 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 134676001289 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 134676001290 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 134676001291 NAD(P) binding site [chemical binding]; other site 134676001292 active site 134676001293 benzoate transport; Region: 2A0115; TIGR00895 134676001294 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 134676001295 putative substrate translocation pore; other site 134676001296 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 134676001297 Domain of unknown function (DUF397); Region: DUF397; pfam04149 134676001298 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 134676001299 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 134676001300 DNA binding residues [nucleotide binding] 134676001301 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 134676001302 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 134676001303 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 134676001304 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 134676001305 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 134676001306 putative PBP binding loops; other site 134676001307 ABC-ATPase subunit interface; other site 134676001308 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 134676001309 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 134676001310 Walker A/P-loop; other site 134676001311 ATP binding site [chemical binding]; other site 134676001312 Q-loop/lid; other site 134676001313 NB-ARC domain; Region: NB-ARC; pfam00931 134676001314 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 134676001315 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 134676001316 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 134676001317 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 134676001318 putative active site [active] 134676001319 hypothetical protein; Provisional; Region: PRK02947 134676001320 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 134676001321 putative active site [active] 134676001322 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cd00413 134676001323 active site 134676001324 catalytic residues [active] 134676001325 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 134676001326 ATP cone domain; Region: ATP-cone; pfam03477 134676001327 ribonucleoside-diphosphate reductase, alpha subunit; Region: NrdE_NrdA; TIGR02506 134676001328 Class I ribonucleotide reductase; Region: RNR_I; cd01679 134676001329 active site 134676001330 dimer interface [polypeptide binding]; other site 134676001331 catalytic residues [active] 134676001332 effector binding site; other site 134676001333 R2 peptide binding site; other site 134676001334 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 134676001335 dimer interface [polypeptide binding]; other site 134676001336 putative radical transfer pathway; other site 134676001337 diiron center [ion binding]; other site 134676001338 tyrosyl radical; other site 134676001339 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 134676001340 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 134676001341 metal ion-dependent adhesion site (MIDAS); other site 134676001342 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 134676001343 intersubunit interface [polypeptide binding]; other site 134676001344 active site 134676001345 catalytic residue [active] 134676001346 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 134676001347 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 134676001348 DNA-binding site [nucleotide binding]; DNA binding site 134676001349 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 134676001350 Predicted integral membrane proteins containing uncharacterized repeats [Function unknown]; Region: COG5563 134676001351 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 134676001352 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 134676001353 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 134676001354 DNA binding residues [nucleotide binding] 134676001355 Haemolysin-III related; Region: HlyIII; cl03831 134676001356 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 134676001357 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 134676001358 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676001359 metal binding site [ion binding]; metal-binding site 134676001360 active site 134676001361 I-site; other site 134676001362 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 134676001363 Fungalysin metallopeptidase (M36); Region: Peptidase_M36; pfam02128 134676001364 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 134676001365 Zn binding site [ion binding]; other site 134676001366 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 134676001367 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 134676001368 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676001369 metal binding site [ion binding]; metal-binding site 134676001370 active site 134676001371 I-site; other site 134676001372 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 134676001373 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 134676001374 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 134676001375 DNA binding residues [nucleotide binding] 134676001376 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 134676001377 RHS Repeat; Region: RHS_repeat; cl11982 134676001378 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 134676001379 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 134676001380 protein-splicing catalytic site; other site 134676001381 thioester formation/cholesterol transfer; other site 134676001382 Pretoxin HINT domain; Region: PT-HINT; pfam07591 134676001383 Clp amino terminal domain; Region: Clp_N; pfam02861 134676001384 Predicted membrane protein [Function unknown]; Region: COG1511 134676001385 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 134676001386 MMPL family; Region: MMPL; pfam03176 134676001387 MMPL family; Region: MMPL; pfam03176 134676001388 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 134676001389 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676001390 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 134676001391 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 134676001392 Transcriptional regulators [Transcription]; Region: MarR; COG1846 134676001393 MarR family; Region: MarR_2; pfam12802 134676001394 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 134676001395 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 134676001396 catalytic motif [active] 134676001397 Zn binding site [ion binding]; other site 134676001398 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 134676001399 dimerization interface [polypeptide binding]; other site 134676001400 active site 134676001401 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 134676001402 active site 134676001403 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 134676001404 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 134676001405 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 134676001406 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 134676001407 active site 134676001408 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 134676001409 aromatic chitin/cellulose binding site residues [chemical binding]; other site 134676001410 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 134676001411 aromatic chitin/cellulose binding site residues [chemical binding]; other site 134676001412 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 134676001413 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 134676001414 generic binding surface II; other site 134676001415 generic binding surface I; other site 134676001416 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 134676001417 putative active site [active] 134676001418 putative catalytic site [active] 134676001419 putative Mg binding site IVb [ion binding]; other site 134676001420 putative phosphate binding site [ion binding]; other site 134676001421 putative DNA binding site [nucleotide binding]; other site 134676001422 putative Mg binding site IVa [ion binding]; other site 134676001423 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 134676001424 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 134676001425 active site 134676001426 metal binding site [ion binding]; metal-binding site 134676001427 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 134676001428 PKD domain; Region: PKD; pfam00801 134676001429 Transcriptional regulator [Transcription]; Region: LysR; COG0583 134676001430 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 134676001431 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 134676001432 dimerization interface [polypeptide binding]; other site 134676001433 SnoaL-like domain; Region: SnoaL_2; pfam12680 134676001434 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 134676001435 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 134676001436 Uncharacterized conserved protein [Function unknown]; Region: COG3268 134676001437 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 134676001438 Methyltransferase domain; Region: Methyltransf_23; pfam13489 134676001439 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 134676001440 S-adenosylmethionine binding site [chemical binding]; other site 134676001441 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 134676001442 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 134676001443 DPG_synthase is involved in protein N-linked glycosylation; Region: DPG_synthase; cd04188 134676001444 Putative Catalytic site; other site 134676001445 DXD motif; other site 134676001446 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 134676001447 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 134676001448 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 134676001449 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 134676001450 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 134676001451 dimerization interface [polypeptide binding]; other site 134676001452 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 134676001453 dimer interface [polypeptide binding]; other site 134676001454 phosphorylation site [posttranslational modification] 134676001455 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676001456 ATP binding site [chemical binding]; other site 134676001457 Mg2+ binding site [ion binding]; other site 134676001458 G-X-G motif; other site 134676001459 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 134676001460 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676001461 active site 134676001462 phosphorylation site [posttranslational modification] 134676001463 intermolecular recognition site; other site 134676001464 dimerization interface [polypeptide binding]; other site 134676001465 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 134676001466 DNA binding site [nucleotide binding] 134676001467 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 134676001468 binding surface 134676001469 TPR motif; other site 134676001470 TPR repeat; Region: TPR_11; pfam13414 134676001471 Smr domain; Region: Smr; pfam01713 134676001472 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 134676001473 Peptidase family M28; Region: Peptidase_M28; pfam04389 134676001474 metal binding site [ion binding]; metal-binding site 134676001475 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 134676001476 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676001477 active site 134676001478 phosphorylation site [posttranslational modification] 134676001479 intermolecular recognition site; other site 134676001480 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 134676001481 CHASE3 domain; Region: CHASE3; pfam05227 134676001482 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 134676001483 dimer interface [polypeptide binding]; other site 134676001484 phosphorylation site [posttranslational modification] 134676001485 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676001486 ATP binding site [chemical binding]; other site 134676001487 Mg2+ binding site [ion binding]; other site 134676001488 G-X-G motif; other site 134676001489 Response regulator receiver domain; Region: Response_reg; pfam00072 134676001490 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676001491 active site 134676001492 phosphorylation site [posttranslational modification] 134676001493 intermolecular recognition site; other site 134676001494 dimerization interface [polypeptide binding]; other site 134676001495 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 134676001496 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 134676001497 active site 134676001498 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 134676001499 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 134676001500 NAD(P) binding site [chemical binding]; other site 134676001501 active site 134676001502 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 134676001503 Catalytic domain of Protein Kinases; Region: PKc; cd00180 134676001504 active site 134676001505 ATP binding site [chemical binding]; other site 134676001506 substrate binding site [chemical binding]; other site 134676001507 activation loop (A-loop); other site 134676001508 Cellulose binding domain; Region: CBM_2; cl17741 134676001509 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 134676001510 classical (c) SDRs; Region: SDR_c; cd05233 134676001511 NAD(P) binding site [chemical binding]; other site 134676001512 active site 134676001513 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 134676001514 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 134676001515 ATP binding site [chemical binding]; other site 134676001516 putative Mg++ binding site [ion binding]; other site 134676001517 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 134676001518 nucleotide binding region [chemical binding]; other site 134676001519 ATP-binding site [chemical binding]; other site 134676001520 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 134676001521 Coenzyme A binding pocket [chemical binding]; other site 134676001522 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 134676001523 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 134676001524 putative homodimer interface [polypeptide binding]; other site 134676001525 putative homotetramer interface [polypeptide binding]; other site 134676001526 putative allosteric switch controlling residues; other site 134676001527 putative metal binding site [ion binding]; other site 134676001528 putative homodimer-homodimer interface [polypeptide binding]; other site 134676001529 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 134676001530 metal-binding site [ion binding] 134676001531 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 134676001532 S-adenosylmethionine binding site [chemical binding]; other site 134676001533 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl17299 134676001534 heme ligand [chemical binding]; other site 134676001535 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl17299 134676001536 heme binding pocket [chemical binding]; other site 134676001537 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 134676001538 DEAD-like helicases superfamily; Region: DEXDc; smart00487 134676001539 ATP binding site [chemical binding]; other site 134676001540 Mg++ binding site [ion binding]; other site 134676001541 motif III; other site 134676001542 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 134676001543 nucleotide binding region [chemical binding]; other site 134676001544 ATP-binding site [chemical binding]; other site 134676001545 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 134676001546 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 134676001547 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676001548 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 134676001549 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 134676001550 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 134676001551 catalytic site [active] 134676001552 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 134676001553 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 134676001554 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 134676001555 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 134676001556 ATP binding site [chemical binding]; other site 134676001557 substrate interface [chemical binding]; other site 134676001558 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 134676001559 active site residue [active] 134676001560 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 134676001561 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 134676001562 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 134676001563 putative catalytic cysteine [active] 134676001564 gamma-glutamyl kinase; Provisional; Region: PRK05429 134676001565 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 134676001566 nucleotide binding site [chemical binding]; other site 134676001567 homotetrameric interface [polypeptide binding]; other site 134676001568 putative phosphate binding site [ion binding]; other site 134676001569 putative allosteric binding site; other site 134676001570 PUA domain; Region: PUA; pfam01472 134676001571 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 134676001572 DNA binding site [nucleotide binding] 134676001573 active site 134676001574 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 134676001575 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 134676001576 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676001577 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 134676001578 atypical (a) SDRs, subgroup 3; Region: SDR_a3; cd05229 134676001579 putative NAD(P) binding site [chemical binding]; other site 134676001580 putative active site [active] 134676001581 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 134676001582 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 134676001583 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 134676001584 Fic family protein [Function unknown]; Region: COG3177 134676001585 Fic/DOC family; Region: Fic; pfam02661 134676001586 NADH dehydrogenase subunit B; Validated; Region: PRK06411 134676001587 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 134676001588 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 134676001589 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 134676001590 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 134676001591 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 134676001592 DNA binding residues [nucleotide binding] 134676001593 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 134676001594 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 134676001595 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 134676001596 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 134676001597 4Fe-4S binding domain; Region: Fer4; pfam00037 134676001598 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 134676001599 NADH dehydrogenase subunit J; Provisional; Region: PRK06439 134676001600 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 134676001601 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 134676001602 proton-translocating NADH-quinone oxidoreductase, chain M; Region: NDH_I_M; TIGR01972 134676001603 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 134676001604 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 134676001605 heat shock protein HtpX; Provisional; Region: PRK03072 134676001606 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 134676001607 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 134676001608 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 134676001609 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 134676001610 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 134676001611 MOSC domain; Region: MOSC; pfam03473 134676001612 Predicted acetyltransferase [General function prediction only]; Region: COG2388 134676001613 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 134676001614 putative active site [active] 134676001615 Phosphotransferase enzyme family; Region: APH; pfam01636 134676001616 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 134676001617 substrate binding site [chemical binding]; other site 134676001618 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 134676001619 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 134676001620 LysE type translocator; Region: LysE; cl00565 134676001621 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 134676001622 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 134676001623 active site residue [active] 134676001624 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 134676001625 active site residue [active] 134676001626 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 134676001627 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 134676001628 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 134676001629 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676001630 metal binding site [ion binding]; metal-binding site 134676001631 active site 134676001632 I-site; other site 134676001633 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 134676001634 ribosomal protein gene cluster 134676001635 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 134676001636 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 134676001637 active site 134676001638 catalytic site [active] 134676001639 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 134676001640 active site 134676001641 catalytic site [active] 134676001642 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 134676001643 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 134676001644 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 134676001645 putative homodimer interface [polypeptide binding]; other site 134676001646 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 134676001647 heterodimer interface [polypeptide binding]; other site 134676001648 homodimer interface [polypeptide binding]; other site 134676001649 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 134676001650 mRNA/rRNA interface [nucleotide binding]; other site 134676001651 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 134676001652 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 134676001653 Walker A/P-loop; other site 134676001654 ATP binding site [chemical binding]; other site 134676001655 ABC transporter signature motif; other site 134676001656 Walker B; other site 134676001657 D-loop; other site 134676001658 H-loop/switch region; other site 134676001659 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 134676001660 23S rRNA interface [nucleotide binding]; other site 134676001661 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 134676001662 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 134676001663 core dimer interface [polypeptide binding]; other site 134676001664 peripheral dimer interface [polypeptide binding]; other site 134676001665 L10 interface [polypeptide binding]; other site 134676001666 L11 interface [polypeptide binding]; other site 134676001667 putative EF-Tu interaction site [polypeptide binding]; other site 134676001668 putative EF-G interaction site [polypeptide binding]; other site 134676001669 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 134676001670 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 134676001671 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 134676001672 RPB1 interaction site [polypeptide binding]; other site 134676001673 RPB10 interaction site [polypeptide binding]; other site 134676001674 RPB11 interaction site [polypeptide binding]; other site 134676001675 RPB3 interaction site [polypeptide binding]; other site 134676001676 RPB12 interaction site [polypeptide binding]; other site 134676001677 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 134676001678 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 134676001679 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 134676001680 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 134676001681 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 134676001682 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 134676001683 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 134676001684 G-loop; other site 134676001685 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 134676001686 DNA binding site [nucleotide binding] 134676001687 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 134676001688 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 134676001689 S17 interaction site [polypeptide binding]; other site 134676001690 S8 interaction site; other site 134676001691 16S rRNA interaction site [nucleotide binding]; other site 134676001692 streptomycin interaction site [chemical binding]; other site 134676001693 23S rRNA interaction site [nucleotide binding]; other site 134676001694 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 134676001695 30S ribosomal protein S7; Validated; Region: PRK05302 134676001696 elongation factor G; Reviewed; Region: PRK00007 134676001697 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 134676001698 G1 box; other site 134676001699 putative GEF interaction site [polypeptide binding]; other site 134676001700 GTP/Mg2+ binding site [chemical binding]; other site 134676001701 Switch I region; other site 134676001702 G2 box; other site 134676001703 G3 box; other site 134676001704 Switch II region; other site 134676001705 G4 box; other site 134676001706 G5 box; other site 134676001707 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 134676001708 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 134676001709 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 134676001710 elongation factor Tu; Reviewed; Region: PRK00049 134676001711 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 134676001712 G1 box; other site 134676001713 GEF interaction site [polypeptide binding]; other site 134676001714 GTP/Mg2+ binding site [chemical binding]; other site 134676001715 Switch I region; other site 134676001716 G2 box; other site 134676001717 G3 box; other site 134676001718 Switch II region; other site 134676001719 G4 box; other site 134676001720 G5 box; other site 134676001721 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 134676001722 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 134676001723 Antibiotic Binding Site [chemical binding]; other site 134676001724 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 134676001725 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 134676001726 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 134676001727 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 134676001728 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 134676001729 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 134676001730 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 134676001731 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 134676001732 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 134676001733 putative translocon binding site; other site 134676001734 protein-rRNA interface [nucleotide binding]; other site 134676001735 ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009 134676001736 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 134676001737 G-X-X-G motif; other site 134676001738 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 134676001739 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 134676001740 23S rRNA interface [nucleotide binding]; other site 134676001741 5S rRNA interface [nucleotide binding]; other site 134676001742 putative antibiotic binding site [chemical binding]; other site 134676001743 L25 interface [polypeptide binding]; other site 134676001744 L27 interface [polypeptide binding]; other site 134676001745 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 134676001746 23S rRNA interface [nucleotide binding]; other site 134676001747 putative translocon interaction site; other site 134676001748 signal recognition particle (SRP54) interaction site; other site 134676001749 L23 interface [polypeptide binding]; other site 134676001750 trigger factor interaction site; other site 134676001751 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 134676001752 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 134676001753 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 134676001754 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 134676001755 RNA binding site [nucleotide binding]; other site 134676001756 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 134676001757 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 134676001758 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 134676001759 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 134676001760 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 134676001761 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 134676001762 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 134676001763 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 134676001764 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 134676001765 5S rRNA interface [nucleotide binding]; other site 134676001766 L27 interface [polypeptide binding]; other site 134676001767 23S rRNA interface [nucleotide binding]; other site 134676001768 L5 interface [polypeptide binding]; other site 134676001769 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 134676001770 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 134676001771 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 134676001772 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 134676001773 23S rRNA binding site [nucleotide binding]; other site 134676001774 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 134676001775 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 134676001776 SecY translocase; Region: SecY; pfam00344 134676001777 adenylate kinase; Reviewed; Region: adk; PRK00279 134676001778 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 134676001779 AMP-binding site [chemical binding]; other site 134676001780 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 134676001781 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 134676001782 active site 134676001783 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 134676001784 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 134676001785 rRNA binding site [nucleotide binding]; other site 134676001786 predicted 30S ribosome binding site; other site 134676001787 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 134676001788 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 134676001789 30S ribosomal protein S13; Region: bact_S13; TIGR03631 134676001790 30S ribosomal protein S11; Validated; Region: PRK05309 134676001791 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 134676001792 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 134676001793 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 134676001794 RNA binding surface [nucleotide binding]; other site 134676001795 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 134676001796 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 134676001797 alphaNTD - beta interaction site [polypeptide binding]; other site 134676001798 alphaNTD homodimer interface [polypeptide binding]; other site 134676001799 alphaNTD - beta' interaction site [polypeptide binding]; other site 134676001800 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 134676001801 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 134676001802 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 134676001803 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 134676001804 dimerization interface 3.5A [polypeptide binding]; other site 134676001805 active site 134676001806 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 134676001807 S-adenosylmethionine binding site [chemical binding]; other site 134676001808 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 134676001809 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 134676001810 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 134676001811 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 134676001812 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 134676001813 thiamine phosphate binding site [chemical binding]; other site 134676001814 active site 134676001815 pyrophosphate binding site [ion binding]; other site 134676001816 hydroxyglutarate oxidase; Provisional; Region: PRK11728 134676001817 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 134676001818 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 134676001819 thiS-thiF/thiG interaction site; other site 134676001820 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 134676001821 ThiS interaction site; other site 134676001822 putative active site [active] 134676001823 tetramer interface [polypeptide binding]; other site 134676001824 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 134676001825 thiamine phosphate binding site [chemical binding]; other site 134676001826 active site 134676001827 pyrophosphate binding site [ion binding]; other site 134676001828 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 134676001829 dimer interface [polypeptide binding]; other site 134676001830 substrate binding site [chemical binding]; other site 134676001831 ATP binding site [chemical binding]; other site 134676001832 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 134676001833 ThiC-associated domain; Region: ThiC-associated; pfam13667 134676001834 ThiC family; Region: ThiC; pfam01964 134676001835 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 134676001836 Catalytic site [active] 134676001837 ribonuclease; Region: Ribonuclease; pfam00545 134676001838 active site 134676001839 Nitrate and nitrite sensing; Region: NIT; pfam08376 134676001840 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 134676001841 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676001842 ATP binding site [chemical binding]; other site 134676001843 Mg2+ binding site [ion binding]; other site 134676001844 G-X-G motif; other site 134676001845 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 134676001846 Protein of unknown function (DUF742); Region: DUF742; pfam05331 134676001847 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 134676001848 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 134676001849 G1 box; other site 134676001850 GTP/Mg2+ binding site [chemical binding]; other site 134676001851 G2 box; other site 134676001852 Switch I region; other site 134676001853 G3 box; other site 134676001854 Switch II region; other site 134676001855 G4 box; other site 134676001856 G5 box; other site 134676001857 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 134676001858 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 134676001859 active site 134676001860 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 134676001861 DNA binding site [nucleotide binding] 134676001862 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 134676001863 23S rRNA interface [nucleotide binding]; other site 134676001864 L3 interface [polypeptide binding]; other site 134676001865 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 134676001866 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 134676001867 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 134676001868 active site 134676001869 substrate binding site [chemical binding]; other site 134676001870 metal binding site [ion binding]; metal-binding site 134676001871 aminotransferase; Validated; Region: PRK07777 134676001872 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 134676001873 pyridoxal 5'-phosphate binding site [chemical binding]; other site 134676001874 homodimer interface [polypeptide binding]; other site 134676001875 catalytic residue [active] 134676001876 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 134676001877 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 134676001878 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 134676001879 glutaminase active site [active] 134676001880 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 134676001881 dimer interface [polypeptide binding]; other site 134676001882 active site 134676001883 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 134676001884 dimer interface [polypeptide binding]; other site 134676001885 active site 134676001886 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 134676001887 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 134676001888 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 134676001889 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 134676001890 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 134676001891 alanine racemase; Reviewed; Region: alr; PRK00053 134676001892 active site 134676001893 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 134676001894 dimer interface [polypeptide binding]; other site 134676001895 substrate binding site [chemical binding]; other site 134676001896 catalytic residues [active] 134676001897 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 134676001898 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 134676001899 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 134676001900 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 134676001901 ligand binding site [chemical binding]; other site 134676001902 active site 134676001903 UGI interface [polypeptide binding]; other site 134676001904 catalytic site [active] 134676001905 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 134676001906 Glycoprotease family; Region: Peptidase_M22; pfam00814 134676001907 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 134676001908 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 134676001909 Coenzyme A binding pocket [chemical binding]; other site 134676001910 UGMP family protein; Validated; Region: PRK09604 134676001911 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 134676001912 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 134676001913 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 134676001914 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 134676001915 ABC transporter signature motif; other site 134676001916 Walker B; other site 134676001917 D-loop; other site 134676001918 H-loop/switch region; other site 134676001919 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 134676001920 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 134676001921 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 134676001922 Walker A/P-loop; other site 134676001923 ATP binding site [chemical binding]; other site 134676001924 Q-loop/lid; other site 134676001925 ABC transporter signature motif; other site 134676001926 Walker B; other site 134676001927 D-loop; other site 134676001928 H-loop/switch region; other site 134676001929 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 134676001930 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 134676001931 ring oligomerisation interface [polypeptide binding]; other site 134676001932 ATP/Mg binding site [chemical binding]; other site 134676001933 stacking interactions; other site 134676001934 hinge regions; other site 134676001935 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 134676001936 oligomerisation interface [polypeptide binding]; other site 134676001937 mobile loop; other site 134676001938 roof hairpin; other site 134676001939 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 134676001940 putative deacylase active site [active] 134676001941 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 134676001942 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 134676001943 putative ligand binding site [chemical binding]; other site 134676001944 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 134676001945 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 134676001946 Walker A/P-loop; other site 134676001947 ATP binding site [chemical binding]; other site 134676001948 Q-loop/lid; other site 134676001949 ABC transporter signature motif; other site 134676001950 Walker B; other site 134676001951 D-loop; other site 134676001952 H-loop/switch region; other site 134676001953 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 134676001954 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 134676001955 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 134676001956 TM-ABC transporter signature motif; other site 134676001957 MarR family; Region: MarR_2; pfam12802 134676001958 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 134676001959 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 134676001960 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 134676001961 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 134676001962 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 134676001963 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 134676001964 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 134676001965 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 134676001966 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 134676001967 Moco binding site; other site 134676001968 metal coordination site [ion binding]; other site 134676001969 Transcription factor WhiB; Region: Whib; pfam02467 134676001970 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 134676001971 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 134676001972 DNA binding residues [nucleotide binding] 134676001973 dimerization interface [polypeptide binding]; other site 134676001974 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 134676001975 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 134676001976 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 134676001977 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 134676001978 active site 134676001979 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 134676001980 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 134676001981 phosphate binding site [ion binding]; other site 134676001982 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 134676001983 Zn binding site [ion binding]; other site 134676001984 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 134676001985 GMP synthase; Reviewed; Region: guaA; PRK00074 134676001986 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 134676001987 AMP/PPi binding site [chemical binding]; other site 134676001988 candidate oxyanion hole; other site 134676001989 catalytic triad [active] 134676001990 potential glutamine specificity residues [chemical binding]; other site 134676001991 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 134676001992 ATP Binding subdomain [chemical binding]; other site 134676001993 Ligand Binding sites [chemical binding]; other site 134676001994 Dimerization subdomain; other site 134676001995 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 134676001996 nudix motif; other site 134676001997 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 134676001998 nudix motif; other site 134676001999 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 134676002000 nudix motif; other site 134676002001 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 134676002002 nudix motif; other site 134676002003 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 134676002004 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 134676002005 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 134676002006 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 134676002007 PspC domain; Region: PspC; pfam04024 134676002008 PspC domain; Region: PspC; cl00864 134676002009 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 134676002010 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676002011 ATP binding site [chemical binding]; other site 134676002012 G-X-G motif; other site 134676002013 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 134676002014 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676002015 active site 134676002016 phosphorylation site [posttranslational modification] 134676002017 intermolecular recognition site; other site 134676002018 dimerization interface [polypeptide binding]; other site 134676002019 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 134676002020 DNA binding residues [nucleotide binding] 134676002021 dimerization interface [polypeptide binding]; other site 134676002022 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 134676002023 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 134676002024 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 134676002025 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 134676002026 dimer interface [polypeptide binding]; other site 134676002027 conserved gate region; other site 134676002028 putative PBP binding loops; other site 134676002029 ABC-ATPase subunit interface; other site 134676002030 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 134676002031 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 134676002032 dimer interface [polypeptide binding]; other site 134676002033 conserved gate region; other site 134676002034 putative PBP binding loops; other site 134676002035 ABC-ATPase subunit interface; other site 134676002036 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 134676002037 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 134676002038 Walker A/P-loop; other site 134676002039 ATP binding site [chemical binding]; other site 134676002040 Q-loop/lid; other site 134676002041 ABC transporter signature motif; other site 134676002042 Walker B; other site 134676002043 D-loop; other site 134676002044 H-loop/switch region; other site 134676002045 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 134676002046 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 134676002047 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 134676002048 Walker A/P-loop; other site 134676002049 ATP binding site [chemical binding]; other site 134676002050 Q-loop/lid; other site 134676002051 ABC transporter signature motif; other site 134676002052 Walker B; other site 134676002053 D-loop; other site 134676002054 H-loop/switch region; other site 134676002055 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 134676002056 Chorismate mutase type II; Region: CM_2; cl00693 134676002057 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 134676002058 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 134676002059 putative active site [active] 134676002060 putative metal binding site [ion binding]; other site 134676002061 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 134676002062 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 134676002063 Part of AAA domain; Region: AAA_19; pfam13245 134676002064 Family description; Region: UvrD_C_2; pfam13538 134676002065 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 134676002066 Peptidase family M23; Region: Peptidase_M23; pfam01551 134676002067 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 134676002068 Peptidase family M23; Region: Peptidase_M23; pfam01551 134676002069 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 134676002070 B12 binding site [chemical binding]; other site 134676002071 cobalt ligand [ion binding]; other site 134676002072 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 134676002073 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 134676002074 CoA-ligase; Region: Ligase_CoA; pfam00549 134676002075 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 134676002076 CoA binding domain; Region: CoA_binding; smart00881 134676002077 CoA-ligase; Region: Ligase_CoA; pfam00549 134676002078 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 134676002079 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 134676002080 active site 134676002081 substrate binding site [chemical binding]; other site 134676002082 cosubstrate binding site; other site 134676002083 catalytic site [active] 134676002084 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 134676002085 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 134676002086 purine monophosphate binding site [chemical binding]; other site 134676002087 dimer interface [polypeptide binding]; other site 134676002088 putative catalytic residues [active] 134676002089 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 134676002090 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 134676002091 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 134676002092 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 134676002093 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 134676002094 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 134676002095 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 134676002096 isocitrate dehydrogenase; Validated; Region: PRK08299 134676002097 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 134676002098 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 134676002099 dimer interface [polypeptide binding]; other site 134676002100 active site 134676002101 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 134676002102 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 134676002103 DNA-binding site [nucleotide binding]; DNA binding site 134676002104 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 134676002105 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 134676002106 active site 134676002107 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 134676002108 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cl04270 134676002109 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 134676002110 Domain of unknown function (DUF4262); Region: DUF4262; pfam14081 134676002111 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 134676002112 dimer interface [polypeptide binding]; other site 134676002113 putative metal binding site [ion binding]; other site 134676002114 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 134676002115 Methyltransferase domain; Region: Methyltransf_23; pfam13489 134676002116 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 134676002117 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 134676002118 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 134676002119 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 134676002120 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Validated; Region: PRK05537 134676002121 PUA-like domain; Region: PUA_2; pfam14306 134676002122 ATP-sulfurylase; Region: ATP-sulfurylase; pfam01747 134676002123 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 134676002124 ligand-binding site [chemical binding]; other site 134676002125 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 134676002126 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 134676002127 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 134676002128 Walker A/P-loop; other site 134676002129 ATP binding site [chemical binding]; other site 134676002130 Q-loop/lid; other site 134676002131 ABC transporter signature motif; other site 134676002132 Walker B; other site 134676002133 D-loop; other site 134676002134 H-loop/switch region; other site 134676002135 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 134676002136 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 134676002137 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 134676002138 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 134676002139 Walker A/P-loop; other site 134676002140 ATP binding site [chemical binding]; other site 134676002141 Q-loop/lid; other site 134676002142 ABC transporter signature motif; other site 134676002143 Walker B; other site 134676002144 D-loop; other site 134676002145 H-loop/switch region; other site 134676002146 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 134676002147 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 134676002148 dimerization interface [polypeptide binding]; other site 134676002149 putative DNA binding site [nucleotide binding]; other site 134676002150 putative Zn2+ binding site [ion binding]; other site 134676002151 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 134676002152 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 134676002153 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 134676002154 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 134676002155 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 134676002156 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 134676002157 HypX protein, N-terminal hydrolase domain; Region: FMT_core_HypX_N; cd08650 134676002158 putative active site [active] 134676002159 putative substrate binding site [chemical binding]; other site 134676002160 putative cosubstrate binding site; other site 134676002161 catalytic site [active] 134676002162 Carboxy-terminal domain of Formyltransferase and similar domains; Region: FMT_C_like; cl14785 134676002163 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 134676002164 substrate binding site [chemical binding]; other site 134676002165 oxyanion hole (OAH) forming residues; other site 134676002166 trimer interface [polypeptide binding]; other site 134676002167 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 134676002168 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 134676002169 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 134676002170 ATP binding site [chemical binding]; other site 134676002171 putative Mg++ binding site [ion binding]; other site 134676002172 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 134676002173 nucleotide binding region [chemical binding]; other site 134676002174 ATP-binding site [chemical binding]; other site 134676002175 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 134676002176 SurA N-terminal domain; Region: SurA_N_3; cl07813 134676002177 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 134676002178 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 134676002179 homodimer interface [polypeptide binding]; other site 134676002180 metal binding site [ion binding]; metal-binding site 134676002181 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 134676002182 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 134676002183 enolase; Provisional; Region: eno; PRK00077 134676002184 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 134676002185 dimer interface [polypeptide binding]; other site 134676002186 metal binding site [ion binding]; metal-binding site 134676002187 substrate binding pocket [chemical binding]; other site 134676002188 Septum formation initiator; Region: DivIC; pfam04977 134676002189 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 134676002190 Protein of unknown function (DUF501); Region: DUF501; cl00652 134676002191 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 134676002192 Coenzyme A binding pocket [chemical binding]; other site 134676002193 exopolyphosphatase; Region: exo_poly_only; TIGR03706 134676002194 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 134676002195 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 134676002196 ligand binding site [chemical binding]; other site 134676002197 active site 134676002198 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 134676002199 MoxR-like ATPases [General function prediction only]; Region: COG0714 134676002200 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 134676002201 Walker A motif; other site 134676002202 ATP binding site [chemical binding]; other site 134676002203 Walker B motif; other site 134676002204 arginine finger; other site 134676002205 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 134676002206 Protein of unknown function DUF58; Region: DUF58; pfam01882 134676002207 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 134676002208 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 134676002209 Bax inhibitor 1 like; Region: BaxI_1; cl17691 134676002210 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 134676002211 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 134676002212 dimer interface [polypeptide binding]; other site 134676002213 active site 134676002214 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 134676002215 active site 134676002216 catalytic triad [active] 134676002217 oxyanion hole [active] 134676002218 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 134676002219 active site 134676002220 catalytic triad [active] 134676002221 oxyanion hole [active] 134676002222 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 134676002223 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 134676002224 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 134676002225 dimer interface [polypeptide binding]; other site 134676002226 pyridoxal 5'-phosphate binding site [chemical binding]; other site 134676002227 catalytic residue [active] 134676002228 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 134676002229 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 134676002230 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 134676002231 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 134676002232 Coenzyme A binding pocket [chemical binding]; other site 134676002233 ribonuclease Z; Reviewed; Region: PRK00055 134676002234 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 134676002235 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 134676002236 putative active site; other site 134676002237 putative metal binding residues [ion binding]; other site 134676002238 signature motif; other site 134676002239 putative triphosphate binding site [ion binding]; other site 134676002240 CHAD domain; Region: CHAD; pfam05235 134676002241 methionine sulfoxide reductase A; Provisional; Region: PRK00058 134676002242 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 134676002243 nucleotide binding site/active site [active] 134676002244 HIT family signature motif; other site 134676002245 catalytic residue [active] 134676002246 cystathionine gamma-synthase; Provisional; Region: PRK07811 134676002247 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 134676002248 homodimer interface [polypeptide binding]; other site 134676002249 substrate-cofactor binding pocket; other site 134676002250 pyridoxal 5'-phosphate binding site [chemical binding]; other site 134676002251 catalytic residue [active] 134676002252 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 134676002253 Amidase; Region: Amidase; cl11426 134676002254 threonine dehydratase; Provisional; Region: PRK08198 134676002255 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 134676002256 tetramer interface [polypeptide binding]; other site 134676002257 pyridoxal 5'-phosphate binding site [chemical binding]; other site 134676002258 catalytic residue [active] 134676002259 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 134676002260 Peptidase family M48; Region: Peptidase_M48; cl12018 134676002261 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 134676002262 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 134676002263 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 134676002264 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 134676002265 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 134676002266 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676002267 metal binding site [ion binding]; metal-binding site 134676002268 active site 134676002269 I-site; other site 134676002270 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 134676002271 CARDB; Region: CARDB; pfam07705 134676002272 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 134676002273 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 134676002274 catalytic residues [active] 134676002275 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 134676002276 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 134676002277 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 134676002278 ATP-grasp domain; Region: ATP-grasp; pfam02222 134676002279 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 134676002280 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 134676002281 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 134676002282 active site 134676002283 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 134676002284 NHL repeat; Region: NHL; pfam01436 134676002285 LytB protein; Region: LYTB; cl00507 134676002286 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 134676002287 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 134676002288 S-adenosylmethionine binding site [chemical binding]; other site 134676002289 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676002290 metal binding site [ion binding]; metal-binding site 134676002291 active site 134676002292 I-site; other site 134676002293 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 134676002294 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 134676002295 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 134676002296 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 134676002297 Walker A/P-loop; other site 134676002298 ATP binding site [chemical binding]; other site 134676002299 Q-loop/lid; other site 134676002300 ABC transporter signature motif; other site 134676002301 Walker B; other site 134676002302 D-loop; other site 134676002303 H-loop/switch region; other site 134676002304 FtsX-like permease family; Region: FtsX; pfam02687 134676002305 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 134676002306 DNA binding site [nucleotide binding] 134676002307 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 134676002308 AAA ATPase domain; Region: AAA_16; pfam13191 134676002309 Tetratricopeptide repeat; Region: TPR_12; pfam13424 134676002310 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 134676002311 TPR motif; other site 134676002312 binding surface 134676002313 Tetratricopeptide repeat; Region: TPR_12; pfam13424 134676002314 Transthyretin_like. This domain is present in the transthyretin-like protein (TLP) family which includes transthyretin (TTR) and a transthyretin-related protein called 5-hydroxyisourate hydrolase (HIUase). TTR and HIUase are homotetrameric proteins...; Region: Transthyretin_like; cl17222 134676002315 active site 134676002316 homotetramer interface [polypeptide binding]; other site 134676002317 2-isopropylmalate synthase; Validated; Region: PRK03739 134676002318 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 134676002319 active site 134676002320 catalytic residues [active] 134676002321 metal binding site [ion binding]; metal-binding site 134676002322 AAA ATPase domain; Region: AAA_16; pfam13191 134676002323 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 134676002324 DNA binding residues [nucleotide binding] 134676002325 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 134676002326 dimerization interface [polypeptide binding]; other site 134676002327 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 134676002328 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 134676002329 Ornithine carbamoyltransferase [Amino acid transport and metabolism]; Region: ArgF; COG0078 134676002330 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 134676002331 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 134676002332 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 134676002333 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 134676002334 dimer interface [polypeptide binding]; other site 134676002335 pyridoxal 5'-phosphate binding site [chemical binding]; other site 134676002336 catalytic residue [active] 134676002337 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 134676002338 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 134676002339 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 134676002340 Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471 134676002341 PqqD family protein, HPr-rel-A system; Region: PqqD_rel_X; TIGR04353 134676002342 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 134676002343 Ligand Binding Site [chemical binding]; other site 134676002344 Molecular Tunnel; other site 134676002345 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 134676002346 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 134676002347 Walker A/P-loop; other site 134676002348 ATP binding site [chemical binding]; other site 134676002349 Q-loop/lid; other site 134676002350 ABC transporter signature motif; other site 134676002351 Walker B; other site 134676002352 D-loop; other site 134676002353 H-loop/switch region; other site 134676002354 non-ribosomal peptide synthetase gene cluster (cACPL_1) 134676002355 DNA binding site [nucleotide binding] 134676002356 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 134676002357 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 134676002358 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 134676002359 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 134676002360 Walker A motif; other site 134676002361 ATP binding site [chemical binding]; other site 134676002362 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 134676002363 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 134676002364 MbtH-like protein; Region: MbtH; cl01279 134676002365 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 134676002366 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 134676002367 acyl-activating enzyme (AAE) consensus motif; other site 134676002368 AMP binding site [chemical binding]; other site 134676002369 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 134676002370 Condensation domain; Region: Condensation; pfam00668 134676002371 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 134676002372 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 134676002373 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 134676002374 acyl-activating enzyme (AAE) consensus motif; other site 134676002375 AMP binding site [chemical binding]; other site 134676002376 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 134676002377 Condensation domain; Region: Condensation; pfam00668 134676002378 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 134676002379 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 134676002380 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 134676002381 acyl-activating enzyme (AAE) consensus motif; other site 134676002382 AMP binding site [chemical binding]; other site 134676002383 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 134676002384 Condensation domain; Region: Condensation; pfam00668 134676002385 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 134676002386 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 134676002387 acyl-activating enzyme (AAE) consensus motif; other site 134676002388 AMP binding site [chemical binding]; other site 134676002389 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 134676002390 Condensation domain; Region: Condensation; pfam00668 134676002391 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 134676002392 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 134676002393 acyl-activating enzyme (AAE) consensus motif; other site 134676002394 AMP binding site [chemical binding]; other site 134676002395 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 134676002396 Condensation domain; Region: Condensation; pfam00668 134676002397 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 134676002398 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 134676002399 acyl-activating enzyme (AAE) consensus motif; other site 134676002400 AMP binding site [chemical binding]; other site 134676002401 Condensation domain; Region: Condensation; pfam00668 134676002402 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 134676002403 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 134676002404 acyl-activating enzyme (AAE) consensus motif; other site 134676002405 AMP binding site [chemical binding]; other site 134676002406 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 134676002407 Condensation domain; Region: Condensation; pfam00668 134676002408 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 134676002409 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 134676002410 acyl-activating enzyme (AAE) consensus motif; other site 134676002411 AMP binding site [chemical binding]; other site 134676002412 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 134676002413 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 134676002414 Beta-lactamase; Region: Beta-lactamase; pfam00144 134676002415 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 134676002416 putative substrate translocation pore; other site 134676002417 MMPL family; Region: MMPL; pfam03176 134676002418 MMPL family; Region: MMPL; pfam03176 134676002419 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 134676002420 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 134676002421 MbtH-like protein; Region: MbtH; pfam03621 134676002422 Condensation domain; Region: Condensation; pfam00668 134676002423 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 134676002424 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 134676002425 acyl-activating enzyme (AAE) consensus motif; other site 134676002426 AMP binding site [chemical binding]; other site 134676002427 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 134676002428 Condensation domain; Region: Condensation; pfam00668 134676002429 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 134676002430 Condensation domain; Region: Condensation; pfam00668 134676002431 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 134676002432 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 134676002433 dimerization interface [polypeptide binding]; other site 134676002434 putative DNA binding site [nucleotide binding]; other site 134676002435 putative Zn2+ binding site [ion binding]; other site 134676002436 Transcriptional regulator PadR-like family; Region: PadR; cl17335 134676002437 Condensation domain; Region: Condensation; pfam00668 134676002438 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 134676002439 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 134676002440 acyl-activating enzyme (AAE) consensus motif; other site 134676002441 AMP binding site [chemical binding]; other site 134676002442 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 134676002443 Prolyl oligopeptidase, N-terminal beta-propeller domain; Region: Peptidase_S9_N; pfam02897 134676002444 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 134676002445 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 134676002446 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 134676002447 DNA binding residues [nucleotide binding] 134676002448 translocation protein TolB; Provisional; Region: tolB; PRK00178 134676002449 radical SAM/SPASM domain, FxsB family; Region: SAM_SPASM_FxsB; TIGR04269 134676002450 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 134676002451 FeS/SAM binding site; other site 134676002452 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 134676002453 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 134676002454 active site 134676002455 metal binding site [ion binding]; metal-binding site 134676002456 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 134676002457 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 134676002458 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 134676002459 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 134676002460 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 134676002461 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 134676002462 salt bridge; other site 134676002463 non-specific DNA binding site [nucleotide binding]; other site 134676002464 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 134676002465 sequence-specific DNA binding site [nucleotide binding]; other site 134676002466 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 134676002467 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 134676002468 Transcriptional regulators [Transcription]; Region: PurR; COG1609 134676002469 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 134676002470 DNA binding site [nucleotide binding] 134676002471 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 134676002472 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 134676002473 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 134676002474 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 134676002475 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 134676002476 putative sugar binding sites [chemical binding]; other site 134676002477 Q-X-W motif; other site 134676002478 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 134676002479 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 134676002480 Cadherin repeat-like domain; Region: CA_like; cl15786 134676002481 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 134676002482 metal binding site [ion binding]; metal-binding site 134676002483 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 134676002484 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 134676002485 DNA-binding site [nucleotide binding]; DNA binding site 134676002486 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 134676002487 pyridoxal 5'-phosphate binding site [chemical binding]; other site 134676002488 homodimer interface [polypeptide binding]; other site 134676002489 catalytic residue [active] 134676002490 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 134676002491 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 134676002492 homodimer interface [polypeptide binding]; other site 134676002493 substrate-cofactor binding pocket; other site 134676002494 pyridoxal 5'-phosphate binding site [chemical binding]; other site 134676002495 catalytic residue [active] 134676002496 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 134676002497 TIGR03089 family protein; Region: TIGR03089 134676002498 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 134676002499 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 134676002500 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 134676002501 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 134676002502 Substrate binding site; other site 134676002503 Cupin domain; Region: Cupin_2; cl17218 134676002504 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 134676002505 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 134676002506 nudix motif; other site 134676002507 GTP and metal dependent enzyme involved F420 coenzyme biosynthesis (catalyzes addition of two l-glutamates to F420 precursor) [Coenzyme transport and metabolism]; Region: COG1478 134676002508 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 134676002509 LPPG:FO 2-phospho-L-lactate transferase; Provisional; Region: PRK13606 134676002510 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 134676002511 phosphate binding site [ion binding]; other site 134676002512 dimer interface [polypeptide binding]; other site 134676002513 FO synthase; Reviewed; Region: fbiC; PRK09234 134676002514 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 134676002515 FeS/SAM binding site; other site 134676002516 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 134676002517 FeS/SAM binding site; other site 134676002518 Transcription factor WhiB; Region: Whib; pfam02467 134676002519 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 134676002520 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 134676002521 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 134676002522 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 134676002523 NodB motif; other site 134676002524 active site 134676002525 catalytic site [active] 134676002526 metal binding site [ion binding]; metal-binding site 134676002527 Protein of unknown function (DUF779); Region: DUF779; pfam05610 134676002528 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 134676002529 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 134676002530 NAD(P) binding site [chemical binding]; other site 134676002531 catalytic residues [active] 134676002532 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 134676002533 DNA binding site [nucleotide binding] 134676002534 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 134676002535 Active_site [active] 134676002536 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 134676002537 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 134676002538 active site 134676002539 substrate binding site [chemical binding]; other site 134676002540 metal binding site [ion binding]; metal-binding site 134676002541 Trm112p-like protein; Region: Trm112p; cl01066 134676002542 bifunctional phosphoglucose/phosphomannose isomerase; Validated; Region: PRK08674 134676002543 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 134676002544 The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_2; cd05637 134676002545 dimer interface [polypeptide binding]; other site 134676002546 active site 134676002547 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 134676002548 Cation efflux family; Region: Cation_efflux; pfam01545 134676002549 Phosphomannose isomerase type I; Region: PMI_typeI; pfam01238 134676002550 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 134676002551 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 134676002552 Helix-turn-helix domain; Region: HTH_31; pfam13560 134676002553 sequence-specific DNA binding site [nucleotide binding]; other site 134676002554 salt bridge; other site 134676002555 Domain of unknown function (DUF397); Region: DUF397; pfam04149 134676002556 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 134676002557 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676002558 active site 134676002559 phosphorylation site [posttranslational modification] 134676002560 intermolecular recognition site; other site 134676002561 dimerization interface [polypeptide binding]; other site 134676002562 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 134676002563 DNA binding site [nucleotide binding] 134676002564 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 134676002565 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 134676002566 dimer interface [polypeptide binding]; other site 134676002567 phosphorylation site [posttranslational modification] 134676002568 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676002569 ATP binding site [chemical binding]; other site 134676002570 Mg2+ binding site [ion binding]; other site 134676002571 G-X-G motif; other site 134676002572 Sporulation and spore germination; Region: Germane; cl11253 134676002573 Lipoprotein LpqB beta-propeller domain; Region: Gmad1; pfam10647 134676002574 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 134676002575 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 134676002576 active site 134676002577 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 134676002578 30S subunit binding site; other site 134676002579 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 134676002580 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 134676002581 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 134676002582 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 134676002583 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 134676002584 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 134676002585 nucleotide binding region [chemical binding]; other site 134676002586 SEC-C motif; Region: SEC-C; pfam02810 134676002587 Helix-turn-helix domain; Region: HTH_17; pfam12728 134676002588 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 134676002589 putative DNA binding site [nucleotide binding]; other site 134676002590 Predicted transcriptional regulators [Transcription]; Region: COG1695 134676002591 putative Zn2+ binding site [ion binding]; other site 134676002592 peptide chain release factor 2; Validated; Region: prfB; PRK00578 134676002593 This domain is found in peptide chain release factors; Region: PCRF; smart00937 134676002594 RF-1 domain; Region: RF-1; pfam00472 134676002595 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 134676002596 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 134676002597 Walker A/P-loop; other site 134676002598 ATP binding site [chemical binding]; other site 134676002599 Q-loop/lid; other site 134676002600 ABC transporter signature motif; other site 134676002601 Walker B; other site 134676002602 D-loop; other site 134676002603 H-loop/switch region; other site 134676002604 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 134676002605 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 134676002606 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 134676002607 Peptidase family M23; Region: Peptidase_M23; pfam01551 134676002608 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 134676002609 SmpB-tmRNA interface; other site 134676002610 CBD_II domain; Region: CBD_II; smart00637 134676002611 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 134676002612 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 134676002613 catalytic residues [active] 134676002614 catalytic nucleophile [active] 134676002615 Recombinase; Region: Recombinase; pfam07508 134676002616 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 134676002617 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 134676002618 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 134676002619 non-specific DNA binding site [nucleotide binding]; other site 134676002620 salt bridge; other site 134676002621 sequence-specific DNA binding site [nucleotide binding]; other site 134676002622 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 134676002623 nudix motif; other site 134676002624 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 134676002625 Zn2+ binding site [ion binding]; other site 134676002626 Mg2+ binding site [ion binding]; other site 134676002627 DDE superfamily endonuclease; Region: DDE_5; pfam13546 134676002628 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 134676002629 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 134676002630 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 134676002631 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 134676002632 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 134676002633 active site 134676002634 Zn binding site [ion binding]; other site 134676002635 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 134676002636 aromatic chitin/cellulose binding site residues [chemical binding]; other site 134676002637 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 134676002638 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 134676002639 non-specific DNA binding site [nucleotide binding]; other site 134676002640 salt bridge; other site 134676002641 sequence-specific DNA binding site [nucleotide binding]; other site 134676002642 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 134676002643 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 134676002644 non-specific DNA binding site [nucleotide binding]; other site 134676002645 salt bridge; other site 134676002646 sequence-specific DNA binding site [nucleotide binding]; other site 134676002647 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 134676002648 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 134676002649 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 134676002650 DNA binding residues [nucleotide binding] 134676002651 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 134676002652 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 134676002653 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 134676002654 ligand binding site [chemical binding]; other site 134676002655 homodimer interface [polypeptide binding]; other site 134676002656 NAD(P) binding site [chemical binding]; other site 134676002657 trimer interface B [polypeptide binding]; other site 134676002658 trimer interface A [polypeptide binding]; other site 134676002659 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 134676002660 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 134676002661 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 134676002662 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 134676002663 hypothetical protein; Validated; Region: PRK00228 134676002664 5'-methylthioadenosine phosphorylase; Validated; Region: PRK07823 134676002665 Response regulator receiver domain; Region: Response_reg; pfam00072 134676002666 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676002667 active site 134676002668 phosphorylation site [posttranslational modification] 134676002669 intermolecular recognition site; other site 134676002670 dimerization interface [polypeptide binding]; other site 134676002671 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 134676002672 Pilus assembly protein, PilO; Region: PilO; cl01234 134676002673 Competence protein A; Region: Competence_A; pfam11104 134676002674 Cell division protein FtsA; Region: FtsA; cl17206 134676002675 Cell division protein FtsA; Region: FtsA; pfam14450 134676002676 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 134676002677 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 134676002678 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 134676002679 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 134676002680 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 134676002681 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 134676002682 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 134676002683 Walker A motif; other site 134676002684 ATP binding site [chemical binding]; other site 134676002685 Walker B motif; other site 134676002686 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 134676002687 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 134676002688 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 134676002689 Walker A motif; other site 134676002690 ATP binding site [chemical binding]; other site 134676002691 Walker B motif; other site 134676002692 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 134676002693 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 134676002694 conserved cys residue [active] 134676002695 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 134676002696 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 134676002697 putative substrate translocation pore; other site 134676002698 Major Facilitator Superfamily; Region: MFS_1; pfam07690 134676002699 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 134676002700 anti sigma factor interaction site; other site 134676002701 regulatory phosphorylation site [posttranslational modification]; other site 134676002702 Tetratricopeptide repeat; Region: TPR_12; pfam13424 134676002703 Tetratricopeptide repeat; Region: TPR_12; pfam13424 134676002704 Tetratricopeptide repeat; Region: TPR_10; pfam13374 134676002705 Tetratricopeptide repeat; Region: TPR_10; pfam13374 134676002706 Tetratricopeptide repeat; Region: TPR_12; pfam13424 134676002707 Tetratricopeptide repeat; Region: TPR_10; pfam13374 134676002708 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 134676002709 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676002710 metal binding site [ion binding]; metal-binding site 134676002711 active site 134676002712 I-site; other site 134676002713 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 134676002714 HEXXH motif domain; Region: mod_HExxH; TIGR04267 134676002715 Domain of unknown function (DUF427); Region: DUF427; pfam04248 134676002716 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 134676002717 GAF domain; Region: GAF; pfam01590 134676002718 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 134676002719 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 134676002720 polymerase nucleotide-binding site; other site 134676002721 DNA-binding residues [nucleotide binding]; DNA binding site 134676002722 nucleotide binding site [chemical binding]; other site 134676002723 primase nucleotide-binding site [nucleotide binding]; other site 134676002724 Beta protein; Region: Beta_protein; pfam14350 134676002725 Part of AAA domain; Region: AAA_19; pfam13245 134676002726 DNA topoisomerase 2; Provisional; Region: PLN03237 134676002727 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 134676002728 PAS fold; Region: PAS_3; pfam08447 134676002729 putative active site [active] 134676002730 heme pocket [chemical binding]; other site 134676002731 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 134676002732 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 134676002733 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 134676002734 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 134676002735 NAD binding site [chemical binding]; other site 134676002736 catalytic Zn binding site [ion binding]; other site 134676002737 substrate binding site [chemical binding]; other site 134676002738 structural Zn binding site [ion binding]; other site 134676002739 alpha-glucosidase; Provisional; Region: PRK10137 134676002740 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 134676002741 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 134676002742 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 134676002743 active site 134676002744 DNA binding site [nucleotide binding] 134676002745 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 134676002746 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 134676002747 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 134676002748 D-pathway; other site 134676002749 Putative ubiquinol binding site [chemical binding]; other site 134676002750 Low-spin heme (heme b) binding site [chemical binding]; other site 134676002751 Putative water exit pathway; other site 134676002752 Binuclear center (heme o3/CuB) [ion binding]; other site 134676002753 K-pathway; other site 134676002754 Putative proton exit pathway; other site 134676002755 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 134676002756 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 134676002757 putative substrate translocation pore; other site 134676002758 Major Facilitator Superfamily; Region: MFS_1; pfam07690 134676002759 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 134676002760 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 134676002761 Isochorismatase family; Region: Isochorismatase; pfam00857 134676002762 catalytic triad [active] 134676002763 metal binding site [ion binding]; metal-binding site 134676002764 conserved cis-peptide bond; other site 134676002765 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 134676002766 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 134676002767 active site 134676002768 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 134676002769 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 134676002770 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 134676002771 MPN+ (JAMM) motif; other site 134676002772 Zinc-binding site [ion binding]; other site 134676002773 Ubiquitin-like proteins; Region: UBQ; cl00155 134676002774 charged pocket; other site 134676002775 hydrophobic patch; other site 134676002776 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 134676002777 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 134676002778 dimer interface [polypeptide binding]; other site 134676002779 pyridoxal 5'-phosphate binding site [chemical binding]; other site 134676002780 catalytic residue [active] 134676002781 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 134676002782 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 134676002783 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 134676002784 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 134676002785 ribonuclease PH; Reviewed; Region: rph; PRK00173 134676002786 Ribonuclease PH; Region: RNase_PH_bact; cd11362 134676002787 hexamer interface [polypeptide binding]; other site 134676002788 active site 134676002789 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 134676002790 active site 134676002791 dimerization interface [polypeptide binding]; other site 134676002792 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 134676002793 active sites [active] 134676002794 tetramer interface [polypeptide binding]; other site 134676002795 imidazolonepropionase; Provisional; Region: PRK14085 134676002796 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 134676002797 active site 134676002798 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 134676002799 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 134676002800 active site 134676002801 allantoate amidohydrolase; Reviewed; Region: PRK09290 134676002802 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 134676002803 active site 134676002804 metal binding site [ion binding]; metal-binding site 134676002805 dimer interface [polypeptide binding]; other site 134676002806 urocanate hydratase; Provisional; Region: PRK05414 134676002807 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 134676002808 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 134676002809 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 134676002810 putative active site [active] 134676002811 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 134676002812 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 134676002813 MOSC domain; Region: MOSC; pfam03473 134676002814 Endoglucanase C-terminal domain/subunit and related proteins [Carbohydrate transport and metabolism]; Region: COG4305 134676002815 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 134676002816 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 134676002817 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 134676002818 catalytic triad [active] 134676002819 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 134676002820 TIGR02646 family protein; Region: TIGR02646 134676002821 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 134676002822 AAA domain; Region: AAA_21; pfam13304 134676002823 Walker A/P-loop; other site 134676002824 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 134676002825 ABC transporter signature motif; other site 134676002826 Walker B; other site 134676002827 D-loop; other site 134676002828 Thioredoxin; Region: Thioredoxin_4; pfam13462 134676002829 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 134676002830 Methylamine utilisation protein MauE; Region: MauE; pfam07291 134676002831 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 134676002832 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 134676002833 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 134676002834 DNA binding residues [nucleotide binding] 134676002835 CopC domain; Region: CopC; pfam04234 134676002836 Copper resistance protein D; Region: CopD; cl00563 134676002837 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 134676002838 catalytic site [active] 134676002839 putative active site [active] 134676002840 putative substrate binding site [chemical binding]; other site 134676002841 dimer interface [polypeptide binding]; other site 134676002842 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 134676002843 DNA binding site [nucleotide binding] 134676002844 active site 134676002845 Int/Topo IB signature motif; other site 134676002846 DDE superfamily endonuclease; Region: DDE_5; cl17874 134676002847 Cellulose binding domain; Region: CBM_2; pfam00553 134676002848 Glycosyl hydrolase family 12; Region: Glyco_hydro_12; cl03302 134676002849 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 134676002850 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 134676002851 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 134676002852 DNA binding residues [nucleotide binding] 134676002853 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 134676002854 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676002855 Bacterial Ig-like domain; Region: Big_5; pfam13205 134676002856 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 134676002857 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 134676002858 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 134676002859 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 134676002860 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 134676002861 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 134676002862 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 134676002863 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 134676002864 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 134676002865 Predicted flavoprotein [General function prediction only]; Region: COG0431 134676002866 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 134676002867 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 134676002868 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676002869 active site 134676002870 phosphorylation site [posttranslational modification] 134676002871 intermolecular recognition site; other site 134676002872 dimerization interface [polypeptide binding]; other site 134676002873 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 134676002874 DNA binding residues [nucleotide binding] 134676002875 dimerization interface [polypeptide binding]; other site 134676002876 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 134676002877 Histidine kinase; Region: HisKA_3; pfam07730 134676002878 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 134676002879 ATP binding site [chemical binding]; other site 134676002880 Mg2+ binding site [ion binding]; other site 134676002881 G-X-G motif; other site 134676002882 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 134676002883 Cytochrome P450; Region: p450; cl12078 134676002884 ATPase involved in DNA repair; Region: DUF3686; pfam12458 134676002885 AAA domain; Region: AAA_22; pfam13401 134676002886 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 134676002887 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 134676002888 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 134676002889 PAS domain S-box; Region: sensory_box; TIGR00229 134676002890 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 134676002891 putative active site [active] 134676002892 heme pocket [chemical binding]; other site 134676002893 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 134676002894 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676002895 metal binding site [ion binding]; metal-binding site 134676002896 active site 134676002897 I-site; other site 134676002898 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 134676002899 Domain of unknown function (DUF397); Region: DUF397; pfam04149 134676002900 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 134676002901 non-specific DNA binding site [nucleotide binding]; other site 134676002902 salt bridge; other site 134676002903 sequence-specific DNA binding site [nucleotide binding]; other site 134676002904 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 134676002905 Amino acid permease; Region: AA_permease; pfam00324 134676002906 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 134676002907 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 134676002908 Coenzyme A binding pocket [chemical binding]; other site 134676002909 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 134676002910 Member of the Rhodanese Homology Domain superfamily. This CD includes the putative rhodanese-like protein, Psp2, of Yersinia pestis biovar Medievalis and other similar uncharacterized proteins; Region: RHOD_PspE2; cd01521 134676002911 active site residue [active] 134676002912 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 134676002913 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 134676002914 conserved cys residue [active] 134676002915 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 134676002916 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 134676002917 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 134676002918 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 134676002919 FAD binding domain; Region: FAD_binding_4; pfam01565 134676002920 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 134676002921 Predicted transcriptional regulators [Transcription]; Region: COG1695 134676002922 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 134676002923 Response regulator receiver domain; Region: Response_reg; pfam00072 134676002924 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676002925 active site 134676002926 phosphorylation site [posttranslational modification] 134676002927 intermolecular recognition site; other site 134676002928 dimerization interface [polypeptide binding]; other site 134676002929 GAF domain; Region: GAF; pfam01590 134676002930 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 134676002931 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 134676002932 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 134676002933 RUN domain; Region: RUN; cl02689 134676002934 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 134676002935 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 134676002936 oligomer interface [polypeptide binding]; other site 134676002937 metal binding site [ion binding]; metal-binding site 134676002938 metal binding site [ion binding]; metal-binding site 134676002939 putative Cl binding site [ion binding]; other site 134676002940 basic sphincter; other site 134676002941 hydrophobic gate; other site 134676002942 periplasmic entrance; other site 134676002943 Predicted transcriptional regulator [Transcription]; Region: COG2378 134676002944 HTH domain; Region: HTH_11; pfam08279 134676002945 WYL domain; Region: WYL; pfam13280 134676002946 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 134676002947 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 134676002948 A subgroup of the Glycosyl hydrolase family 20 (GH20) catalytic domain found in proteins similar to the N-acetylhexosaminidase from Streptomyces plicatus (SpHex). SpHex catalyzes the hydrolysis of N-acetyl-beta-hexosaminides. An Asp residue within the...; Region: GH20_SpHex_like; cd06568 134676002949 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 134676002950 active site 134676002951 Nitrate and nitrite sensing; Region: NIT; pfam08376 134676002952 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 134676002953 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676002954 ATP binding site [chemical binding]; other site 134676002955 Mg2+ binding site [ion binding]; other site 134676002956 G-X-G motif; other site 134676002957 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 134676002958 Protein of unknown function (DUF742); Region: DUF742; pfam05331 134676002959 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 134676002960 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 134676002961 G1 box; other site 134676002962 GTP/Mg2+ binding site [chemical binding]; other site 134676002963 G2 box; other site 134676002964 Switch I region; other site 134676002965 G3 box; other site 134676002966 Switch II region; other site 134676002967 G4 box; other site 134676002968 G5 box; other site 134676002969 Transcriptional regulators [Transcription]; Region: PurR; COG1609 134676002970 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 134676002971 DNA binding site [nucleotide binding] 134676002972 domain linker motif; other site 134676002973 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 134676002974 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 134676002975 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 134676002976 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 134676002977 metal ion-dependent adhesion site (MIDAS); other site 134676002978 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 134676002979 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 134676002980 xylose isomerase, Arthrobacter type; Region: xylA_Arthro; TIGR02631 134676002981 xylose isomerase; Provisional; Region: PRK12677 134676002982 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 134676002983 D-xylulose kinase; Region: XylB; TIGR01312 134676002984 nucleotide binding site [chemical binding]; other site 134676002985 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 134676002986 Major Facilitator Superfamily; Region: MFS_1; pfam07690 134676002987 putative substrate translocation pore; other site 134676002988 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 134676002989 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 134676002990 active site 134676002991 catalytic site [active] 134676002992 HD domain; Region: HD_4; pfam13328 134676002993 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 134676002994 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 134676002995 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 134676002996 4Fe-4S single cluster domain; Region: Fer4_14; pfam13394 134676002997 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 134676002998 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 134676002999 active site 134676003000 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 134676003001 NAD(P) binding site [chemical binding]; other site 134676003002 active site 134676003003 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 134676003004 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 134676003005 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 134676003006 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 134676003007 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 134676003008 DNA binding residues [nucleotide binding] 134676003009 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 134676003010 NlpC/P60 family; Region: NLPC_P60; pfam00877 134676003011 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 134676003012 Glucitol operon activator protein (GutM); Region: GutM; cl01890 134676003013 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 134676003014 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 134676003015 GAF domain; Region: GAF; pfam01590 134676003016 ANTAR domain; Region: ANTAR; pfam03861 134676003017 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 134676003018 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 134676003019 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 134676003020 putative substrate translocation pore; other site 134676003021 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 134676003022 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 134676003023 putative DNA binding site [nucleotide binding]; other site 134676003024 putative Zn2+ binding site [ion binding]; other site 134676003025 Predicted methyltransferase [General function prediction only]; Region: COG3897 134676003026 Predicted methyltransferase [General function prediction only]; Region: COG3897 134676003027 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 134676003028 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 134676003029 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676003030 active site 134676003031 phosphorylation site [posttranslational modification] 134676003032 intermolecular recognition site; other site 134676003033 dimerization interface [polypeptide binding]; other site 134676003034 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 134676003035 DNA binding residues [nucleotide binding] 134676003036 dimerization interface [polypeptide binding]; other site 134676003037 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 134676003038 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 134676003039 ligand binding site [chemical binding]; other site 134676003040 NAD binding site [chemical binding]; other site 134676003041 tetramer interface [polypeptide binding]; other site 134676003042 catalytic site [active] 134676003043 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 134676003044 L-serine binding site [chemical binding]; other site 134676003045 ACT domain interface; other site 134676003046 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898 134676003047 putative active site [active] 134676003048 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 134676003049 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 134676003050 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 134676003051 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 134676003052 dimer interface [polypeptide binding]; other site 134676003053 ssDNA binding site [nucleotide binding]; other site 134676003054 tetramer (dimer of dimers) interface [polypeptide binding]; other site 134676003055 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 134676003056 cobyric acid synthase; Provisional; Region: PRK00784 134676003057 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 134676003058 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 134676003059 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 134676003060 catalytic triad [active] 134676003061 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 134676003062 hypothetical protein; Provisional; Region: PRK07907 134676003063 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 134676003064 active site 134676003065 metal binding site [ion binding]; metal-binding site 134676003066 dimer interface [polypeptide binding]; other site 134676003067 hypothetical protein; Provisional; Region: PRK06184 134676003068 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 134676003069 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 134676003070 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015 134676003071 active site 134676003072 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 134676003073 DNA binding site [nucleotide binding] 134676003074 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 134676003075 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 134676003076 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 134676003077 conserved cys residue [active] 134676003078 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 134676003079 TIGR03086 family protein; Region: TIGR03086 134676003080 Transglycosylase; Region: Transgly; pfam00912 134676003081 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 134676003082 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 134676003083 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 134676003084 pyridoxal 5'-phosphate binding site [chemical binding]; other site 134676003085 homodimer interface [polypeptide binding]; other site 134676003086 catalytic residue [active] 134676003087 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 134676003088 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 134676003089 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 134676003090 putative dimer interface [polypeptide binding]; other site 134676003091 active site pocket [active] 134676003092 putative cataytic base [active] 134676003093 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 134676003094 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 134676003095 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 134676003096 active site 134676003097 SAM binding site [chemical binding]; other site 134676003098 homodimer interface [polypeptide binding]; other site 134676003099 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 134676003100 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 134676003101 active site 134676003102 homotetramer interface [polypeptide binding]; other site 134676003103 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 134676003104 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 134676003105 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 134676003106 ABC transporter; Region: ABC_tran_2; pfam12848 134676003107 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 134676003108 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 134676003109 active site 134676003110 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 134676003111 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 134676003112 apolar tunnel; other site 134676003113 heme binding site [chemical binding]; other site 134676003114 dimerization interface [polypeptide binding]; other site 134676003115 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 134676003116 putative substrate translocation pore; other site 134676003117 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 134676003118 Mechanosensitive ion channel; Region: MS_channel; pfam00924 134676003119 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 134676003120 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 134676003121 active site 134676003122 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 134676003123 active site 134676003124 putative catalytic site [active] 134676003125 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 134676003126 putative active site [active] 134676003127 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 134676003128 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 134676003129 Zn binding site [ion binding]; other site 134676003130 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 134676003131 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 134676003132 catalytic residues [active] 134676003133 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 134676003134 Uncharacterized conserved protein [Function unknown]; Region: COG4198 134676003135 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 134676003136 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 134676003137 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 134676003138 tetramer (dimer of dimers) interface [polypeptide binding]; other site 134676003139 active site 134676003140 dimer interface [polypeptide binding]; other site 134676003141 hypothetical protein; Provisional; Region: PRK01346 134676003142 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 134676003143 Coenzyme A binding pocket [chemical binding]; other site 134676003144 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 134676003145 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 134676003146 Probable Catalytic site; other site 134676003147 metal-binding site 134676003148 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 134676003149 hydrophobic ligand binding site; other site 134676003150 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 134676003151 putative DNA binding site [nucleotide binding]; other site 134676003152 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 134676003153 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 134676003154 Fasciclin domain; Region: Fasciclin; pfam02469 134676003155 Putative zinc-finger; Region: zf-HC2; pfam13490 134676003156 Anti-sigma-K factor rskA; Region: RskA; pfam10099 134676003157 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 134676003158 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 134676003159 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 134676003160 DNA binding residues [nucleotide binding] 134676003161 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 134676003162 dimerization interface [polypeptide binding]; other site 134676003163 putative DNA binding site [nucleotide binding]; other site 134676003164 putative Zn2+ binding site [ion binding]; other site 134676003165 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 134676003166 Major Facilitator Superfamily; Region: MFS_1; pfam07690 134676003167 putative substrate translocation pore; other site 134676003168 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 134676003169 active site 134676003170 catalytic residues [active] 134676003171 YCII-related domain; Region: YCII; cl00999 134676003172 YCII-related domain; Region: YCII; cl00999 134676003173 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 134676003174 putative hydrophobic ligand binding site [chemical binding]; other site 134676003175 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 134676003176 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 134676003177 NAD binding site [chemical binding]; other site 134676003178 catalytic Zn binding site [ion binding]; other site 134676003179 structural Zn binding site [ion binding]; other site 134676003180 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 134676003181 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 134676003182 NAD binding site [chemical binding]; other site 134676003183 catalytic Zn binding site [ion binding]; other site 134676003184 structural Zn binding site [ion binding]; other site 134676003185 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 134676003186 conserved cys residue [active] 134676003187 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 134676003188 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 134676003189 nudix motif; other site 134676003190 trigger factor; Provisional; Region: tig; PRK01490 134676003191 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 134676003192 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 134676003193 Clp protease; Region: CLP_protease; pfam00574 134676003194 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 134676003195 oligomer interface [polypeptide binding]; other site 134676003196 active site residues [active] 134676003197 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 134676003198 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 134676003199 oligomer interface [polypeptide binding]; other site 134676003200 active site residues [active] 134676003201 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 134676003202 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 134676003203 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 134676003204 Walker A motif; other site 134676003205 ATP binding site [chemical binding]; other site 134676003206 Walker B motif; other site 134676003207 arginine finger; other site 134676003208 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 134676003209 nitrilase; Region: PLN02798 134676003210 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 134676003211 putative active site [active] 134676003212 catalytic triad [active] 134676003213 dimer interface [polypeptide binding]; other site 134676003214 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 134676003215 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 134676003216 HIGH motif; other site 134676003217 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 134676003218 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 134676003219 active site 134676003220 KMSKS motif; other site 134676003221 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 134676003222 tRNA binding surface [nucleotide binding]; other site 134676003223 anticodon binding site; other site 134676003224 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 134676003225 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 134676003226 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 134676003227 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 134676003228 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 134676003229 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 134676003230 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 134676003231 active site 134676003232 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 134676003233 active site 134676003234 multimer interface [polypeptide binding]; other site 134676003235 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 134676003236 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 134676003237 HIGH motif; other site 134676003238 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 134676003239 active site 134676003240 KMSKS motif; other site 134676003241 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 134676003242 tRNA binding surface [nucleotide binding]; other site 134676003243 anticodon binding site; other site 134676003244 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 134676003245 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 134676003246 putative acyl-acceptor binding pocket; other site 134676003247 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 134676003248 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 134676003249 catalytic site [active] 134676003250 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 134676003251 PAS domain; Region: PAS_9; pfam13426 134676003252 putative active site [active] 134676003253 heme pocket [chemical binding]; other site 134676003254 GAF domain; Region: GAF_3; pfam13492 134676003255 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 134676003256 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 134676003257 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 134676003258 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 134676003259 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 134676003260 ATP binding site [chemical binding]; other site 134676003261 Mg2+ binding site [ion binding]; other site 134676003262 G-X-G motif; other site 134676003263 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 134676003264 anti sigma factor interaction site; other site 134676003265 regulatory phosphorylation site [posttranslational modification]; other site 134676003266 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 134676003267 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 134676003268 B12 binding site [chemical binding]; other site 134676003269 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 134676003270 FeS/SAM binding site; other site 134676003271 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 134676003272 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 134676003273 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 134676003274 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 134676003275 homodimer interface [polypeptide binding]; other site 134676003276 oligonucleotide binding site [chemical binding]; other site 134676003277 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 134676003278 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 134676003279 GTPase CgtA; Reviewed; Region: obgE; PRK12296 134676003280 GTP1/OBG; Region: GTP1_OBG; pfam01018 134676003281 Obg GTPase; Region: Obg; cd01898 134676003282 G1 box; other site 134676003283 GTP/Mg2+ binding site [chemical binding]; other site 134676003284 Switch I region; other site 134676003285 G2 box; other site 134676003286 G3 box; other site 134676003287 Switch II region; other site 134676003288 G4 box; other site 134676003289 G5 box; other site 134676003290 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 134676003291 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 134676003292 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 134676003293 Coenzyme A binding pocket [chemical binding]; other site 134676003294 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 134676003295 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 134676003296 active site 134676003297 HIGH motif; other site 134676003298 dimer interface [polypeptide binding]; other site 134676003299 KMSKS motif; other site 134676003300 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 134676003301 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 134676003302 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 134676003303 Zn binding site [ion binding]; other site 134676003304 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 134676003305 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 134676003306 putative active site [active] 134676003307 heme pocket [chemical binding]; other site 134676003308 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 134676003309 dimer interface [polypeptide binding]; other site 134676003310 phosphorylation site [posttranslational modification] 134676003311 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676003312 ATP binding site [chemical binding]; other site 134676003313 Mg2+ binding site [ion binding]; other site 134676003314 G-X-G motif; other site 134676003315 Response regulator receiver domain; Region: Response_reg; pfam00072 134676003316 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676003317 active site 134676003318 phosphorylation site [posttranslational modification] 134676003319 intermolecular recognition site; other site 134676003320 dimerization interface [polypeptide binding]; other site 134676003321 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 134676003322 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 134676003323 active site 134676003324 (T/H)XGH motif; other site 134676003325 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 134676003326 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 134676003327 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 134676003328 EDD domain protein, DegV family; Region: DegV; TIGR00762 134676003329 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 134676003330 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 134676003331 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 134676003332 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 134676003333 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 134676003334 Competence protein; Region: Competence; pfam03772 134676003335 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 134676003336 DNA polymerase III, delta subunit; Region: holA; TIGR01128 134676003337 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 134676003338 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 134676003339 Protein of unknown function (DUF4240); Region: DUF4240; pfam14024 134676003340 molybdenum cofactor biosynthesis protein MoaC/MOSC-domain-containing protein; Provisional; Region: PRK14499 134676003341 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 134676003342 GTP-binding protein LepA; Provisional; Region: PRK05433 134676003343 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 134676003344 G1 box; other site 134676003345 putative GEF interaction site [polypeptide binding]; other site 134676003346 GTP/Mg2+ binding site [chemical binding]; other site 134676003347 Switch I region; other site 134676003348 G2 box; other site 134676003349 G3 box; other site 134676003350 Switch II region; other site 134676003351 G4 box; other site 134676003352 G5 box; other site 134676003353 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 134676003354 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 134676003355 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 134676003356 Predicted membrane protein [Function unknown]; Region: COG2261 134676003357 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 134676003358 PAS domain; Region: PAS_9; pfam13426 134676003359 putative active site [active] 134676003360 heme pocket [chemical binding]; other site 134676003361 enoyl-CoA hydratase; Provisional; Region: PRK07827 134676003362 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 134676003363 substrate binding site [chemical binding]; other site 134676003364 oxyanion hole (OAH) forming residues; other site 134676003365 trimer interface [polypeptide binding]; other site 134676003366 coproporphyrinogen III oxidase; Validated; Region: PRK05628 134676003367 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 134676003368 FeS/SAM binding site; other site 134676003369 HemN C-terminal domain; Region: HemN_C; pfam06969 134676003370 Tic20-like protein; Region: Tic20; pfam09685 134676003371 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 134676003372 HTH domain; Region: HTH_11; cl17392 134676003373 chaperone protein DnaJ; Provisional; Region: PRK14278 134676003374 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 134676003375 HSP70 interaction site [polypeptide binding]; other site 134676003376 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 134676003377 Zn binding sites [ion binding]; other site 134676003378 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 134676003379 dimer interface [polypeptide binding]; other site 134676003380 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 134676003381 RNA methyltransferase, RsmE family; Region: TIGR00046 134676003382 Predicted transcriptional regulators [Transcription]; Region: COG1695 134676003383 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 134676003384 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 134676003385 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 134676003386 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 134676003387 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 134676003388 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 134676003389 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 134676003390 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 134676003391 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 134676003392 nucleotide binding site/active site [active] 134676003393 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 134676003394 Beta-lactamase; Region: Beta-lactamase; pfam00144 134676003395 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 134676003396 PhoH-like protein; Region: PhoH; pfam02562 134676003397 metal-binding heat shock protein; Provisional; Region: PRK00016 134676003398 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 134676003399 Domain of unknown function DUF21; Region: DUF21; pfam01595 134676003400 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 134676003401 Transporter associated domain; Region: CorC_HlyC; smart01091 134676003402 GTPase Era; Reviewed; Region: era; PRK00089 134676003403 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 134676003404 G1 box; other site 134676003405 GTP/Mg2+ binding site [chemical binding]; other site 134676003406 Switch I region; other site 134676003407 G2 box; other site 134676003408 Switch II region; other site 134676003409 G3 box; other site 134676003410 G4 box; other site 134676003411 G5 box; other site 134676003412 KH domain; Region: KH_2; pfam07650 134676003413 Acyltransferase family; Region: Acyl_transf_3; pfam01757 134676003414 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 134676003415 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 134676003416 Recombination protein O N terminal; Region: RecO_N; pfam11967 134676003417 Recombination protein O C terminal; Region: RecO_C; pfam02565 134676003418 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14829 134676003419 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 134676003420 catalytic residue [active] 134676003421 putative FPP diphosphate binding site; other site 134676003422 putative FPP binding hydrophobic cleft; other site 134676003423 dimer interface [polypeptide binding]; other site 134676003424 putative IPP diphosphate binding site; other site 134676003425 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 134676003426 catalytic core [active] 134676003427 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 134676003428 Domain of unknown function DUF77; Region: DUF77; pfam01910 134676003429 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 134676003430 Cobalt transport protein; Region: CbiQ; cl00463 134676003431 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 134676003432 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 134676003433 Walker A/P-loop; other site 134676003434 ATP binding site [chemical binding]; other site 134676003435 Q-loop/lid; other site 134676003436 ABC transporter signature motif; other site 134676003437 Walker B; other site 134676003438 D-loop; other site 134676003439 H-loop/switch region; other site 134676003440 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 134676003441 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 134676003442 Walker A/P-loop; other site 134676003443 ATP binding site [chemical binding]; other site 134676003444 Q-loop/lid; other site 134676003445 ABC transporter signature motif; other site 134676003446 Walker B; other site 134676003447 D-loop; other site 134676003448 H-loop/switch region; other site 134676003449 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 134676003450 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 134676003451 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 134676003452 metal binding site 2 [ion binding]; metal-binding site 134676003453 putative DNA binding helix; other site 134676003454 metal binding site 1 [ion binding]; metal-binding site 134676003455 dimer interface [polypeptide binding]; other site 134676003456 structural Zn2+ binding site [ion binding]; other site 134676003457 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 134676003458 dimerization interface [polypeptide binding]; other site 134676003459 putative DNA binding site [nucleotide binding]; other site 134676003460 putative Zn2+ binding site [ion binding]; other site 134676003461 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 134676003462 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 134676003463 ABC-ATPase subunit interface; other site 134676003464 dimer interface [polypeptide binding]; other site 134676003465 putative PBP binding regions; other site 134676003466 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 134676003467 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 134676003468 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 134676003469 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 134676003470 intersubunit interface [polypeptide binding]; other site 134676003471 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 134676003472 Lumazine-binding domain; Region: Lumazine_bd; pfam12870 134676003473 glycyl-tRNA synthetase; Provisional; Region: PRK04173 134676003474 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 134676003475 dimer interface [polypeptide binding]; other site 134676003476 motif 1; other site 134676003477 active site 134676003478 motif 2; other site 134676003479 motif 3; other site 134676003480 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 134676003481 anticodon binding site; other site 134676003482 XdhC Rossmann domain; Region: XdhC_C; pfam13478 134676003483 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 134676003484 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 134676003485 FMN binding site [chemical binding]; other site 134676003486 active site 134676003487 catalytic residues [active] 134676003488 substrate binding site [chemical binding]; other site 134676003489 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 134676003490 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 134676003491 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 134676003492 active site 134676003493 metal binding site [ion binding]; metal-binding site 134676003494 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 134676003495 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 134676003496 dimer interface [polypeptide binding]; other site 134676003497 putative CheW interface [polypeptide binding]; other site 134676003498 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 134676003499 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 134676003500 Zn2+ binding site [ion binding]; other site 134676003501 Mg2+ binding site [ion binding]; other site 134676003502 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 134676003503 DNA primase; Validated; Region: dnaG; PRK05667 134676003504 CHC2 zinc finger; Region: zf-CHC2; pfam01807 134676003505 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 134676003506 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 134676003507 active site 134676003508 metal binding site [ion binding]; metal-binding site 134676003509 interdomain interaction site; other site 134676003510 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 134676003511 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 134676003512 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 134676003513 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 134676003514 Walker A/P-loop; other site 134676003515 ATP binding site [chemical binding]; other site 134676003516 Q-loop/lid; other site 134676003517 ABC transporter signature motif; other site 134676003518 Walker B; other site 134676003519 D-loop; other site 134676003520 H-loop/switch region; other site 134676003521 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 134676003522 ABC-2 type transporter; Region: ABC2_membrane; cl17235 134676003523 ABC-2 type transporter; Region: ABC2_membrane; cl17235 134676003524 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 134676003525 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 134676003526 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 134676003527 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 134676003528 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 134676003529 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 134676003530 Family description; Region: UvrD_C_2; pfam13538 134676003531 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 134676003532 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 134676003533 short chain dehydrogenase; Validated; Region: PRK08264 134676003534 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 134676003535 NAD(P) binding site [chemical binding]; other site 134676003536 active site 134676003537 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 134676003538 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 134676003539 DNA binding residues [nucleotide binding] 134676003540 putative dimer interface [polypeptide binding]; other site 134676003541 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 134676003542 Predicted membrane protein [Function unknown]; Region: COG4325 134676003543 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 134676003544 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 134676003545 putative sugar binding sites [chemical binding]; other site 134676003546 Q-X-W motif; other site 134676003547 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 134676003548 active site 134676003549 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 134676003550 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 134676003551 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 134676003552 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 134676003553 calcium mediated ligand binding site; other site 134676003554 intermolecular salt bridges; other site 134676003555 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 134676003556 Domain of unknown function (DUF1845); Region: DUF1845; cl07481 134676003557 PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398 134676003558 active site 134676003559 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 134676003560 CheW-like domain; Region: CheW; pfam01584 134676003561 PAS domain; Region: PAS_9; pfam13426 134676003562 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 134676003563 putative active site [active] 134676003564 heme pocket [chemical binding]; other site 134676003565 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 134676003566 PAS domain; Region: PAS_9; pfam13426 134676003567 putative active site [active] 134676003568 heme pocket [chemical binding]; other site 134676003569 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 134676003570 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 134676003571 dimer interface [polypeptide binding]; other site 134676003572 putative CheW interface [polypeptide binding]; other site 134676003573 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 134676003574 YDG/SRA domain; Region: YDG_SRA; pfam02182 134676003575 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 134676003576 active site 134676003577 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 134676003578 active site 134676003579 catalytic triad [active] 134676003580 oxyanion hole [active] 134676003581 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 134676003582 H+ Antiporter protein; Region: 2A0121; TIGR00900 134676003583 putative substrate translocation pore; other site 134676003584 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 134676003585 radical SAM/SPASM domain, FxsB family; Region: SAM_SPASM_FxsB; TIGR04269 134676003586 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 134676003587 FeS/SAM binding site; other site 134676003588 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 134676003589 TIR domain; Region: TIR_2; cl17458 134676003590 FxsC C-terminal domain; Region: FxsC_Cterm; TIGR04276 134676003591 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 134676003592 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 134676003593 P-loop; other site 134676003594 Magnesium ion binding site [ion binding]; other site 134676003595 TIR domain; Region: TIR_2; pfam13676 134676003596 AAA ATPase domain; Region: AAA_16; pfam13191 134676003597 NB-ARC domain; Region: NB-ARC; pfam00931 134676003598 Tetratricopeptide repeat; Region: TPR_12; pfam13424 134676003599 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 134676003600 binding surface 134676003601 TPR motif; other site 134676003602 Tetratricopeptide repeat; Region: TPR_12; pfam13424 134676003603 radical SAM/SPASM domain, FxsB family; Region: SAM_SPASM_FxsB; TIGR04269 134676003604 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 134676003605 FeS/SAM binding site; other site 134676003606 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 134676003607 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 134676003608 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 134676003609 P-loop; other site 134676003610 Magnesium ion binding site [ion binding]; other site 134676003611 TIR domain; Region: TIR_2; pfam13676 134676003612 NB-ARC domain; Region: NB-ARC; pfam00931 134676003613 Tetratricopeptide repeat; Region: TPR_12; pfam13424 134676003614 Tetratricopeptide repeat; Region: TPR_12; pfam13424 134676003615 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 134676003616 binding surface 134676003617 TPR motif; other site 134676003618 Tetratricopeptide repeat; Region: TPR_12; pfam13424 134676003619 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 134676003620 binding surface 134676003621 TPR motif; other site 134676003622 Tetratricopeptide repeat; Region: TPR_12; pfam13424 134676003623 Tetratricopeptide repeat; Region: TPR_12; pfam13424 134676003624 Tetratricopeptide repeat; Region: TPR_12; pfam13424 134676003625 Tetratricopeptide repeat; Region: TPR_10; pfam13374 134676003626 Tetratricopeptide repeat; Region: TPR_12; pfam13424 134676003627 Tetratricopeptide repeat; Region: TPR_10; pfam13374 134676003628 TIR domain; Region: TIR_2; pfam13676 134676003629 FxsC C-terminal domain; Region: FxsC_Cterm; TIGR04276 134676003630 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 134676003631 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 134676003632 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 134676003633 active site 134676003634 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 134676003635 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 134676003636 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 134676003637 active site 134676003638 HIGH motif; other site 134676003639 KMSK motif region; other site 134676003640 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 134676003641 tRNA binding surface [nucleotide binding]; other site 134676003642 anticodon binding site; other site 134676003643 2',3'-cyclic-nucleotide 2'-phosphodiesterase; Region: CycNucDiestase; TIGR01390 134676003644 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 134676003645 active site 134676003646 metal binding site [ion binding]; metal-binding site 134676003647 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 134676003648 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 134676003649 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 134676003650 DNA binding residues [nucleotide binding] 134676003651 drug binding residues [chemical binding]; other site 134676003652 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 134676003653 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 134676003654 Catalytic domain of Protein Kinases; Region: PKc; cd00180 134676003655 active site 134676003656 ATP binding site [chemical binding]; other site 134676003657 substrate binding site [chemical binding]; other site 134676003658 activation loop (A-loop); other site 134676003659 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 134676003660 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 134676003661 anti sigma factor interaction site; other site 134676003662 regulatory phosphorylation site [posttranslational modification]; other site 134676003663 Survival protein SurE; Region: SurE; pfam01975 134676003664 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 134676003665 substrate binding site [chemical binding]; other site 134676003666 ATP binding site [chemical binding]; other site 134676003667 Family description; Region: UvrD_C_2; pfam13538 134676003668 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 134676003669 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 134676003670 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 134676003671 active site clefts [active] 134676003672 zinc binding site [ion binding]; other site 134676003673 dimer interface [polypeptide binding]; other site 134676003674 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 134676003675 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 134676003676 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 134676003677 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 134676003678 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 134676003679 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 134676003680 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 134676003681 dimer interface [polypeptide binding]; other site 134676003682 active site 134676003683 acyl carrier protein; Provisional; Region: acpP; PRK00982 134676003684 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 134676003685 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 134676003686 dimer interface [polypeptide binding]; other site 134676003687 active site 134676003688 CoA binding pocket [chemical binding]; other site 134676003689 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 134676003690 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 134676003691 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 134676003692 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676003693 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 134676003694 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 134676003695 active site 134676003696 HIGH motif; other site 134676003697 nucleotide binding site [chemical binding]; other site 134676003698 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 134676003699 active site 134676003700 KMSKS motif; other site 134676003701 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 134676003702 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 134676003703 dimer interface [polypeptide binding]; other site 134676003704 TPP-binding site [chemical binding]; other site 134676003705 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 134676003706 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 134676003707 TPP-binding site [chemical binding]; other site 134676003708 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 134676003709 PYR/PP interface [polypeptide binding]; other site 134676003710 dimer interface [polypeptide binding]; other site 134676003711 TPP binding site [chemical binding]; other site 134676003712 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 134676003713 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 134676003714 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 134676003715 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 134676003716 dimer interface [polypeptide binding]; other site 134676003717 catalytic triad [active] 134676003718 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The...; Region: SANT; cl17250 134676003719 Protein of unknown function (DUF402); Region: DUF402; pfam04167 134676003720 Bifunctional DNA primase/polymerase, N-terminal; Region: Prim-Pol; smart00943 134676003721 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 134676003722 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 134676003723 non-specific DNA binding site [nucleotide binding]; other site 134676003724 salt bridge; other site 134676003725 sequence-specific DNA binding site [nucleotide binding]; other site 134676003726 Flavoprotein; Region: Flavoprotein; pfam02441 134676003727 Uncharacterized conserved protein [Function unknown]; Region: COG0327 134676003728 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 134676003729 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 134676003730 Putative zinc ribbon domain; Region: DUF164; pfam02591 134676003731 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 134676003732 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 134676003733 RNA/DNA hybrid binding site [nucleotide binding]; other site 134676003734 active site 134676003735 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 134676003736 catalytic core [active] 134676003737 Glyco_18 domain; Region: Glyco_18; smart00636 134676003738 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 134676003739 active site 134676003740 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 134676003741 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 134676003742 Na binding site [ion binding]; other site 134676003743 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 134676003744 TIR domain; Region: TIR_2; pfam13676 134676003745 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 134676003746 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 134676003747 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 134676003748 threonine dehydratase; Provisional; Region: PRK08246 134676003749 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 134676003750 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 134676003751 catalytic residue [active] 134676003752 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 134676003753 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 134676003754 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 134676003755 Methyltransferase domain; Region: Methyltransf_31; pfam13847 134676003756 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 134676003757 S-adenosylmethionine binding site [chemical binding]; other site 134676003758 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 134676003759 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 134676003760 Exoribonuclease R [Transcription]; Region: VacB; COG0557 134676003761 RNB domain; Region: RNB; pfam00773 134676003762 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 134676003763 oligomerization interface [polypeptide binding]; other site 134676003764 active site 134676003765 metal binding site [ion binding]; metal-binding site 134676003766 NAD synthetase; Provisional; Region: PRK13981 134676003767 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 134676003768 multimer interface [polypeptide binding]; other site 134676003769 active site 134676003770 catalytic triad [active] 134676003771 protein interface 1 [polypeptide binding]; other site 134676003772 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 134676003773 homodimer interface [polypeptide binding]; other site 134676003774 NAD binding pocket [chemical binding]; other site 134676003775 ATP binding pocket [chemical binding]; other site 134676003776 Mg binding site [ion binding]; other site 134676003777 active-site loop [active] 134676003778 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 134676003779 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 134676003780 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 134676003781 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 134676003782 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 134676003783 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 134676003784 Predicted transcriptional regulator [Transcription]; Region: COG2378 134676003785 HTH domain; Region: HTH_11; pfam08279 134676003786 WYL domain; Region: WYL; pfam13280 134676003787 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 134676003788 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 134676003789 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 134676003790 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 134676003791 catalytic triad [active] 134676003792 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 134676003793 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 134676003794 metal binding triad; other site 134676003795 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 134676003796 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 134676003797 metal binding triad; other site 134676003798 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 134676003799 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 134676003800 MarR family; Region: MarR; pfam01047 134676003801 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 134676003802 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 134676003803 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 134676003804 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 134676003805 Walker A/P-loop; other site 134676003806 ATP binding site [chemical binding]; other site 134676003807 Q-loop/lid; other site 134676003808 ABC transporter signature motif; other site 134676003809 Walker B; other site 134676003810 D-loop; other site 134676003811 H-loop/switch region; other site 134676003812 Bacterial transcriptional activator domain; Region: BTAD; smart01043 134676003813 Predicted ATPase [General function prediction only]; Region: COG3903 134676003814 glutamine synthetase, type I; Region: GlnA; TIGR00653 134676003815 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 134676003816 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 134676003817 Proteins of 100 residues with WXG; Region: WXG100; cl02005 134676003818 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 134676003819 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 134676003820 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 134676003821 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 134676003822 A nuclease of the HNH/ENDO VII superfamily with conserved WHH; Region: WHH; pfam14414 134676003823 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 134676003824 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 134676003825 active site 134676003826 catalytic residues [active] 134676003827 Protein of unknown function (DUF690); Region: DUF690; cl04939 134676003828 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 134676003829 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 134676003830 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 134676003831 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 134676003832 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 134676003833 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 134676003834 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 134676003835 activation loop (A-loop); other site 134676003836 Protein of unknown function (DUF2984); Region: DUF2984; cl12752 134676003837 putative pectinesterase; Region: PLN02432; cl01911 134676003838 Right handed beta helix region; Region: Beta_helix; pfam13229 134676003839 stage V sporulation protein K; Region: spore_V_K; TIGR02881 134676003840 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 134676003841 Walker A motif; other site 134676003842 ATP binding site [chemical binding]; other site 134676003843 Walker B motif; other site 134676003844 arginine finger; other site 134676003845 EBNA-3B; Provisional; Region: PHA03378 134676003846 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 134676003847 Predicted ATPase [General function prediction only]; Region: COG3899 134676003848 AAA ATPase domain; Region: AAA_16; pfam13191 134676003849 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 134676003850 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 134676003851 DNA binding residues [nucleotide binding] 134676003852 dimerization interface [polypeptide binding]; other site 134676003853 lipoyl synthase; Provisional; Region: PRK05481 134676003854 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 134676003855 FeS/SAM binding site; other site 134676003856 aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159 134676003857 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 134676003858 Dimer interface [polypeptide binding]; other site 134676003859 anticodon binding site; other site 134676003860 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 134676003861 motif 1; other site 134676003862 dimer interface [polypeptide binding]; other site 134676003863 active site 134676003864 motif 2; other site 134676003865 motif 3; other site 134676003866 PQQ-like domain; Region: PQQ_2; pfam13360 134676003867 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 134676003868 lipoate-protein ligase B; Provisional; Region: PRK14345 134676003869 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 134676003870 TIGR01777 family protein; Region: yfcH 134676003871 NAD(P) binding site [chemical binding]; other site 134676003872 active site 134676003873 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 134676003874 e3 binding domain; Region: E3_binding; pfam02817 134676003875 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 134676003876 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 134676003877 E3 interaction surface; other site 134676003878 lipoyl attachment site [posttranslational modification]; other site 134676003879 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 134676003880 E3 interaction surface; other site 134676003881 lipoyl attachment site [posttranslational modification]; other site 134676003882 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 134676003883 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 134676003884 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 134676003885 multifunctional aminopeptidase A; Provisional; Region: PRK00913 134676003886 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 134676003887 interface (dimer of trimers) [polypeptide binding]; other site 134676003888 Substrate-binding/catalytic site; other site 134676003889 Zn-binding sites [ion binding]; other site 134676003890 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 134676003891 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 134676003892 cobalamin synthase; Reviewed; Region: cobS; PRK00235 134676003893 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 134676003894 homotrimer interface [polypeptide binding]; other site 134676003895 Walker A motif; other site 134676003896 GTP binding site [chemical binding]; other site 134676003897 Walker B motif; other site 134676003898 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cl11435 134676003899 putative cataytic base [active] 134676003900 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 134676003901 Peptidase family M50; Region: Peptidase_M50; pfam02163 134676003902 active site 134676003903 putative substrate binding region [chemical binding]; other site 134676003904 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 134676003905 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 134676003906 active site 134676003907 catalytic tetrad [active] 134676003908 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 134676003909 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 134676003910 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 134676003911 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 134676003912 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 134676003913 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 134676003914 Walker A/P-loop; other site 134676003915 ATP binding site [chemical binding]; other site 134676003916 Q-loop/lid; other site 134676003917 ABC transporter signature motif; other site 134676003918 Walker B; other site 134676003919 D-loop; other site 134676003920 H-loop/switch region; other site 134676003921 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 134676003922 active site 134676003923 catalytic residues [active] 134676003924 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 134676003925 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 134676003926 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 134676003927 hinge; other site 134676003928 active site 134676003929 quinolinate synthetase; Provisional; Region: PRK09375 134676003930 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 134676003931 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 134676003932 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 134676003933 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 134676003934 substrate binding site [chemical binding]; other site 134676003935 ATP binding site [chemical binding]; other site 134676003936 AAA domain; Region: AAA_33; pfam13671 134676003937 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 134676003938 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 134676003939 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 134676003940 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 134676003941 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 134676003942 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 134676003943 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 134676003944 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 134676003945 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 134676003946 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 134676003947 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 134676003948 Subunit I/III interface [polypeptide binding]; other site 134676003949 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 134676003950 Cytochrome c; Region: Cytochrom_C; pfam00034 134676003951 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 134676003952 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 134676003953 iron-sulfur cluster [ion binding]; other site 134676003954 [2Fe-2S] cluster binding site [ion binding]; other site 134676003955 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 134676003956 heme bH binding site [chemical binding]; other site 134676003957 Qi binding site; other site 134676003958 intrachain domain interface; other site 134676003959 heme bL binding site [chemical binding]; other site 134676003960 interchain domain interface [polypeptide binding]; other site 134676003961 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 134676003962 Qo binding site; other site 134676003963 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 134676003964 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 134676003965 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 134676003966 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 134676003967 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 134676003968 AsnC family; Region: AsnC_trans_reg; pfam01037 134676003969 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 134676003970 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 134676003971 active site 134676003972 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 134676003973 nudix motif; other site 134676003974 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 134676003975 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 134676003976 Zn2+ binding site [ion binding]; other site 134676003977 Mg2+ binding site [ion binding]; other site 134676003978 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 134676003979 synthetase active site [active] 134676003980 NTP binding site [chemical binding]; other site 134676003981 metal binding site [ion binding]; metal-binding site 134676003982 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 134676003983 hypothetical protein; Validated; Region: PRK07883 134676003984 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 134676003985 active site 134676003986 catalytic site [active] 134676003987 substrate binding site [chemical binding]; other site 134676003988 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 134676003989 GIY-YIG motif/motif A; other site 134676003990 active site 134676003991 catalytic site [active] 134676003992 putative DNA binding site [nucleotide binding]; other site 134676003993 metal binding site [ion binding]; metal-binding site 134676003994 YacP-like NYN domain; Region: NYN_YacP; cl01491 134676003995 Peptidase family M48; Region: Peptidase_M48; cl12018 134676003996 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 134676003997 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 134676003998 Protein of unknown function (DUF4240); Region: DUF4240; pfam14024 134676003999 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 134676004000 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 134676004001 Walker A/P-loop; other site 134676004002 ATP binding site [chemical binding]; other site 134676004003 Q-loop/lid; other site 134676004004 ABC transporter signature motif; other site 134676004005 Walker B; other site 134676004006 D-loop; other site 134676004007 H-loop/switch region; other site 134676004008 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 134676004009 catalytic residues [active] 134676004010 H+ Antiporter protein; Region: 2A0121; TIGR00900 134676004011 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 134676004012 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 134676004013 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 134676004014 putative Zn2+ binding site [ion binding]; other site 134676004015 putative DNA binding site [nucleotide binding]; other site 134676004016 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 134676004017 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 134676004018 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676004019 active site 134676004020 phosphorylation site [posttranslational modification] 134676004021 intermolecular recognition site; other site 134676004022 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 134676004023 DNA binding residues [nucleotide binding] 134676004024 dimerization interface [polypeptide binding]; other site 134676004025 GAF domain; Region: GAF_3; pfam13492 134676004026 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 134676004027 Histidine kinase; Region: HisKA_3; pfam07730 134676004028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676004029 ATP binding site [chemical binding]; other site 134676004030 Mg2+ binding site [ion binding]; other site 134676004031 G-X-G motif; other site 134676004032 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 134676004033 putative hydrophobic ligand binding site [chemical binding]; other site 134676004034 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 134676004035 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 134676004036 nucleotide binding site [chemical binding]; other site 134676004037 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 134676004038 putative metal binding site [ion binding]; other site 134676004039 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 134676004040 Flavin-binding monooxygenase-like; Region: FMO-like; pfam00743 134676004041 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 134676004042 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 134676004043 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 134676004044 active site 134676004045 homotetramer interface [polypeptide binding]; other site 134676004046 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 134676004047 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 134676004048 putative acyl-acceptor binding pocket; other site 134676004049 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 134676004050 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 134676004051 ligand binding site [chemical binding]; other site 134676004052 flexible hinge region; other site 134676004053 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 134676004054 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 134676004055 active site 134676004056 ATP binding site [chemical binding]; other site 134676004057 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 134676004058 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676004059 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 134676004060 phosphofructokinase; Region: PFK_mixed; TIGR02483 134676004061 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 134676004062 active site 134676004063 ADP/pyrophosphate binding site [chemical binding]; other site 134676004064 dimerization interface [polypeptide binding]; other site 134676004065 allosteric effector site; other site 134676004066 fructose-1,6-bisphosphate binding site; other site 134676004067 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 134676004068 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 134676004069 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 134676004070 Coenzyme A binding pocket [chemical binding]; other site 134676004071 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 134676004072 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 134676004073 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 134676004074 Protein of unknown function (DUF429); Region: DUF429; pfam04250 134676004075 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 134676004076 catalytic residues [active] 134676004077 dimer interface [polypeptide binding]; other site 134676004078 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 134676004079 aromatic chitin/cellulose binding site residues [chemical binding]; other site 134676004080 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 134676004081 Glyco_18 domain; Region: Glyco_18; smart00636 134676004082 active site 134676004083 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 134676004084 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 134676004085 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 134676004086 tetramer interface [polypeptide binding]; other site 134676004087 pyridoxal 5'-phosphate binding site [chemical binding]; other site 134676004088 catalytic residue [active] 134676004089 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102 134676004090 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 134676004091 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102 134676004092 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 134676004093 AP endonuclease family 2; Region: AP2Ec; smart00518 134676004094 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 134676004095 AP (apurinic/apyrimidinic) site pocket; other site 134676004096 DNA interaction; other site 134676004097 Metal-binding active site; metal-binding site 134676004098 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 134676004099 Catalytic domain of Protein Kinases; Region: PKc; cd00180 134676004100 active site 134676004101 ATP binding site [chemical binding]; other site 134676004102 substrate binding site [chemical binding]; other site 134676004103 activation loop (A-loop); other site 134676004104 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 134676004105 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 134676004106 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 134676004107 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 134676004108 Helix-turn-helix domain; Region: HTH_17; cl17695 134676004109 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 134676004110 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 134676004111 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 134676004112 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 134676004113 substrate binding pocket [chemical binding]; other site 134676004114 chain length determination region; other site 134676004115 substrate-Mg2+ binding site; other site 134676004116 catalytic residues [active] 134676004117 aspartate-rich region 1; other site 134676004118 active site lid residues [active] 134676004119 aspartate-rich region 2; other site 134676004120 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 134676004121 FAD binding site [chemical binding]; other site 134676004122 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 134676004123 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 134676004124 active site 134676004125 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 134676004126 Beta-lactamase; Region: Beta-lactamase; pfam00144 134676004127 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 134676004128 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 134676004129 metal binding site [ion binding]; metal-binding site 134676004130 substrate binding pocket [chemical binding]; other site 134676004131 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 134676004132 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676004133 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 134676004134 hypothetical protein; Provisional; Region: PRK06184 134676004135 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 134676004136 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676004137 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 134676004138 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 134676004139 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 134676004140 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 134676004141 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 134676004142 L-aspartate oxidase; Provisional; Region: PRK06175 134676004143 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 134676004144 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 134676004145 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 134676004146 putative Iron-sulfur protein interface [polypeptide binding]; other site 134676004147 proximal heme binding site [chemical binding]; other site 134676004148 distal heme binding site [chemical binding]; other site 134676004149 putative dimer interface [polypeptide binding]; other site 134676004150 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 134676004151 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 134676004152 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 134676004153 dimerization interface [polypeptide binding]; other site 134676004154 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 134676004155 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 134676004156 S-adenosylmethionine binding site [chemical binding]; other site 134676004157 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 134676004158 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 134676004159 metal ion-dependent adhesion site (MIDAS); other site 134676004160 phytoene desaturase; Region: crtI_fam; TIGR02734 134676004161 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 134676004162 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 134676004163 Protein of unknown function (DUF422); Region: DUF422; cl00991 134676004164 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 134676004165 Domain of unknown function (DUF4188); Region: DUF4188; pfam13826 134676004166 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 134676004167 short chain dehydrogenase; Provisional; Region: PRK06197 134676004168 NAD(P) binding site [chemical binding]; other site 134676004169 active site 134676004170 Amino acid permease; Region: AA_permease_2; pfam13520 134676004171 Domain of unknown function (DUF373); Region: DUF373; cl12079 134676004172 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 134676004173 putative Zn2+ binding site [ion binding]; other site 134676004174 putative DNA binding site [nucleotide binding]; other site 134676004175 Y-family of DNA polymerases; Region: PolY; cl12025 134676004176 active site 134676004177 DNA binding site [nucleotide binding] 134676004178 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 134676004179 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 134676004180 active site 134676004181 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 134676004182 generic binding surface II; other site 134676004183 generic binding surface I; other site 134676004184 Subtilisin inhibitor-like; Region: SSI; cl11594 134676004185 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 134676004186 Methyltransferase domain; Region: Methyltransf_23; pfam13489 134676004187 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 134676004188 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 134676004189 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 134676004190 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 134676004191 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 134676004192 Protein of unknown function DUF58; Region: DUF58; pfam01882 134676004193 MoxR-like ATPases [General function prediction only]; Region: COG0714 134676004194 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 134676004195 Walker A motif; other site 134676004196 ATP binding site [chemical binding]; other site 134676004197 Walker B motif; other site 134676004198 arginine finger; other site 134676004199 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 134676004200 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 134676004201 HIGH motif; other site 134676004202 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 134676004203 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 134676004204 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 134676004205 active site 134676004206 KMSKS motif; other site 134676004207 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 134676004208 tRNA binding surface [nucleotide binding]; other site 134676004209 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 134676004210 Uncharacterized conserved protein [Function unknown]; Region: COG0398 134676004211 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 134676004212 catalytic triad [active] 134676004213 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 134676004214 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 134676004215 NlpC/P60 family; Region: NLPC_P60; cl17555 134676004216 cell division protein MraZ; Reviewed; Region: PRK00326 134676004217 MraZ protein; Region: MraZ; pfam02381 134676004218 MraZ protein; Region: MraZ; pfam02381 134676004219 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 134676004220 MraW methylase family; Region: Methyltransf_5; cl17771 134676004221 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 134676004222 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 134676004223 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 134676004224 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 134676004225 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 134676004226 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 134676004227 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 134676004228 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 134676004229 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 134676004230 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 134676004231 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 134676004232 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 134676004233 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 134676004234 Mg++ binding site [ion binding]; other site 134676004235 putative catalytic motif [active] 134676004236 putative substrate binding site [chemical binding]; other site 134676004237 cell division protein FtsW; Region: ftsW; TIGR02614 134676004238 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 134676004239 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 134676004240 active site 134676004241 homodimer interface [polypeptide binding]; other site 134676004242 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 134676004243 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 134676004244 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 134676004245 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 134676004246 Cell division protein FtsQ; Region: FtsQ; pfam03799 134676004247 cell division protein FtsZ; Validated; Region: PRK09330 134676004248 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 134676004249 nucleotide binding site [chemical binding]; other site 134676004250 SulA interaction site; other site 134676004251 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 134676004252 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 134676004253 catalytic residue [active] 134676004254 Protein of unknown function (DUF552); Region: DUF552; pfam04472 134676004255 YGGT family; Region: YGGT; cl00508 134676004256 DivIVA protein; Region: DivIVA; pfam05103 134676004257 DivIVA domain; Region: DivI1A_domain; TIGR03544 134676004258 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 134676004259 lipoprotein signal peptidase; Provisional; Region: PRK14764 134676004260 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 134676004261 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 134676004262 RNA binding surface [nucleotide binding]; other site 134676004263 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 134676004264 active site 134676004265 AAA domain; Region: AAA_31; pfam13614 134676004266 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 134676004267 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 134676004268 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 134676004269 active site 134676004270 PHP Thumb interface [polypeptide binding]; other site 134676004271 metal binding site [ion binding]; metal-binding site 134676004272 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 134676004273 generic binding surface II; other site 134676004274 generic binding surface I; other site 134676004275 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 134676004276 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 134676004277 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 134676004278 NAD binding site [chemical binding]; other site 134676004279 dimerization interface [polypeptide binding]; other site 134676004280 product binding site; other site 134676004281 substrate binding site [chemical binding]; other site 134676004282 zinc binding site [ion binding]; other site 134676004283 catalytic residues [active] 134676004284 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 134676004285 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 134676004286 pyridoxal 5'-phosphate binding site [chemical binding]; other site 134676004287 homodimer interface [polypeptide binding]; other site 134676004288 catalytic residue [active] 134676004289 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 134676004290 putative active site pocket [active] 134676004291 4-fold oligomerization interface [polypeptide binding]; other site 134676004292 metal binding residues [ion binding]; metal-binding site 134676004293 3-fold/trimer interface [polypeptide binding]; other site 134676004294 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 134676004295 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 134676004296 putative active site [active] 134676004297 oxyanion strand; other site 134676004298 catalytic triad [active] 134676004299 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 134676004300 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 134676004301 catalytic residues [active] 134676004302 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 134676004303 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 134676004304 substrate binding site [chemical binding]; other site 134676004305 glutamase interaction surface [polypeptide binding]; other site 134676004306 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 134676004307 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 134676004308 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 134676004309 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 134676004310 DNA-binding site [nucleotide binding]; DNA binding site 134676004311 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 134676004312 pyridoxal 5'-phosphate binding site [chemical binding]; other site 134676004313 homodimer interface [polypeptide binding]; other site 134676004314 catalytic residue [active] 134676004315 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 134676004316 Predicted membrane protein [Function unknown]; Region: COG2364 134676004317 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 134676004318 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 134676004319 acyl-activating enzyme (AAE) consensus motif; other site 134676004320 putative AMP binding site [chemical binding]; other site 134676004321 putative active site [active] 134676004322 putative CoA binding site [chemical binding]; other site 134676004323 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 134676004324 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 134676004325 ATP binding site [chemical binding]; other site 134676004326 substrate binding site [chemical binding]; other site 134676004327 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 134676004328 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 134676004329 DNA-binding site [nucleotide binding]; DNA binding site 134676004330 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 134676004331 pyridoxal 5'-phosphate binding site [chemical binding]; other site 134676004332 homodimer interface [polypeptide binding]; other site 134676004333 catalytic residue [active] 134676004334 putative transporter; Provisional; Region: PRK11021 134676004335 TIGR03085 family protein; Region: TIGR03085 134676004336 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 134676004337 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 134676004338 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 134676004339 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 134676004340 Walker A/P-loop; other site 134676004341 ATP binding site [chemical binding]; other site 134676004342 Q-loop/lid; other site 134676004343 ABC transporter signature motif; other site 134676004344 Walker B; other site 134676004345 D-loop; other site 134676004346 H-loop/switch region; other site 134676004347 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 134676004348 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 134676004349 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 134676004350 Walker A/P-loop; other site 134676004351 ATP binding site [chemical binding]; other site 134676004352 Q-loop/lid; other site 134676004353 ABC transporter signature motif; other site 134676004354 Walker B; other site 134676004355 D-loop; other site 134676004356 H-loop/switch region; other site 134676004357 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 134676004358 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 134676004359 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 134676004360 RNA binding surface [nucleotide binding]; other site 134676004361 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 134676004362 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 134676004363 anthranilate synthase component I; Provisional; Region: PRK13571 134676004364 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 134676004365 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 134676004366 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; cl17850 134676004367 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 134676004368 active site 134676004369 ribulose/triose binding site [chemical binding]; other site 134676004370 phosphate binding site [ion binding]; other site 134676004371 substrate (anthranilate) binding pocket [chemical binding]; other site 134676004372 product (indole) binding pocket [chemical binding]; other site 134676004373 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 134676004374 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 134676004375 pyridoxal 5'-phosphate binding site [chemical binding]; other site 134676004376 catalytic residue [active] 134676004377 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 134676004378 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 134676004379 substrate binding site [chemical binding]; other site 134676004380 active site 134676004381 catalytic residues [active] 134676004382 heterodimer interface [polypeptide binding]; other site 134676004383 Pyridoxamine-phosphate oxidase [Coenzyme metabolism]; Region: PdxH; COG0259 134676004384 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 134676004385 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 134676004386 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 134676004387 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 134676004388 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 134676004389 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 134676004390 Coenzyme A binding pocket [chemical binding]; other site 134676004391 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 134676004392 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 134676004393 active site 134676004394 dimer interface [polypeptide binding]; other site 134676004395 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 134676004396 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 134676004397 active site 134676004398 FMN binding site [chemical binding]; other site 134676004399 substrate binding site [chemical binding]; other site 134676004400 3Fe-4S cluster binding site [ion binding]; other site 134676004401 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 134676004402 domain interface; other site 134676004403 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 134676004404 pyruvate kinase; Provisional; Region: PRK06247 134676004405 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 134676004406 domain interfaces; other site 134676004407 active site 134676004408 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 134676004409 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 134676004410 active site 134676004411 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 134676004412 catalytic triad [active] 134676004413 dimer interface [polypeptide binding]; other site 134676004414 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 134676004415 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 134676004416 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676004417 active site 134676004418 phosphorylation site [posttranslational modification] 134676004419 intermolecular recognition site; other site 134676004420 dimerization interface [polypeptide binding]; other site 134676004421 ANTAR domain; Region: ANTAR; pfam03861 134676004422 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 134676004423 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 134676004424 dimerization interface [polypeptide binding]; other site 134676004425 ligand binding site [chemical binding]; other site 134676004426 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 134676004427 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 134676004428 TM-ABC transporter signature motif; other site 134676004429 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 134676004430 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 134676004431 TM-ABC transporter signature motif; other site 134676004432 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 134676004433 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 134676004434 Walker A/P-loop; other site 134676004435 ATP binding site [chemical binding]; other site 134676004436 Q-loop/lid; other site 134676004437 ABC transporter signature motif; other site 134676004438 Walker B; other site 134676004439 D-loop; other site 134676004440 H-loop/switch region; other site 134676004441 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 134676004442 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 134676004443 Walker A/P-loop; other site 134676004444 ATP binding site [chemical binding]; other site 134676004445 Q-loop/lid; other site 134676004446 ABC transporter signature motif; other site 134676004447 Walker B; other site 134676004448 D-loop; other site 134676004449 H-loop/switch region; other site 134676004450 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 134676004451 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 134676004452 substrate binding pocket [chemical binding]; other site 134676004453 membrane-bound complex binding site; other site 134676004454 hinge residues; other site 134676004455 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 134676004456 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 134676004457 dimer interface [polypeptide binding]; other site 134676004458 conserved gate region; other site 134676004459 putative PBP binding loops; other site 134676004460 ABC-ATPase subunit interface; other site 134676004461 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 134676004462 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 134676004463 Walker A/P-loop; other site 134676004464 ATP binding site [chemical binding]; other site 134676004465 Q-loop/lid; other site 134676004466 ABC transporter signature motif; other site 134676004467 Walker B; other site 134676004468 D-loop; other site 134676004469 H-loop/switch region; other site 134676004470 DNA polymerase I; Provisional; Region: PRK05755 134676004471 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 134676004472 active site 134676004473 metal binding site 1 [ion binding]; metal-binding site 134676004474 putative 5' ssDNA interaction site; other site 134676004475 metal binding site 3; metal-binding site 134676004476 metal binding site 2 [ion binding]; metal-binding site 134676004477 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 134676004478 putative DNA binding site [nucleotide binding]; other site 134676004479 putative metal binding site [ion binding]; other site 134676004480 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 134676004481 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 134676004482 active site 134676004483 DNA binding site [nucleotide binding] 134676004484 catalytic site [active] 134676004485 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 134676004486 dimerization interface [polypeptide binding]; other site 134676004487 putative DNA binding site [nucleotide binding]; other site 134676004488 putative Zn2+ binding site [ion binding]; other site 134676004489 Protein of unknown function (DUF3140); Region: DUF3140; pfam11338 134676004490 Protein of unknown function (DUF2945); Region: DUF2945; pfam11160 134676004491 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 134676004492 S-adenosylmethionine binding site [chemical binding]; other site 134676004493 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 134676004494 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 134676004495 RNA binding site [nucleotide binding]; other site 134676004496 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 134676004497 RNA binding site [nucleotide binding]; other site 134676004498 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 134676004499 RNA binding site [nucleotide binding]; other site 134676004500 S1 RNA binding domain; Region: S1; pfam00575 134676004501 RNA binding site [nucleotide binding]; other site 134676004502 dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333 134676004503 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 134676004504 CoA-binding site [chemical binding]; other site 134676004505 ATP-binding [chemical binding]; other site 134676004506 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 134676004507 excinuclease ABC subunit B; Provisional; Region: PRK05298 134676004508 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 134676004509 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 134676004510 nucleotide binding region [chemical binding]; other site 134676004511 ATP-binding site [chemical binding]; other site 134676004512 Ultra-violet resistance protein B; Region: UvrB; pfam12344 134676004513 UvrB/uvrC motif; Region: UVR; pfam02151 134676004514 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 134676004515 Integral membrane protein TerC family; Region: TerC; cl10468 134676004516 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 134676004517 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 134676004518 G1 box; other site 134676004519 putative GEF interaction site [polypeptide binding]; other site 134676004520 GTP/Mg2+ binding site [chemical binding]; other site 134676004521 Switch I region; other site 134676004522 G2 box; other site 134676004523 G3 box; other site 134676004524 Switch II region; other site 134676004525 G4 box; other site 134676004526 G5 box; other site 134676004527 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 134676004528 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 134676004529 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 134676004530 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 134676004531 N-acetyl-D-glucosamine binding site [chemical binding]; other site 134676004532 catalytic residue [active] 134676004533 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 134676004534 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 134676004535 23S rRNA interface [nucleotide binding]; other site 134676004536 L7/L12 interface [polypeptide binding]; other site 134676004537 putative thiostrepton binding site; other site 134676004538 L25 interface [polypeptide binding]; other site 134676004539 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 134676004540 Clp protease; Region: CLP_protease; pfam00574 134676004541 active site 134676004542 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 134676004543 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 134676004544 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 134676004545 DNA binding residues [nucleotide binding] 134676004546 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 134676004547 mycothiol-dependent maleylpyruvate isomerase; Reviewed; Region: PRK09583 134676004548 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 134676004549 GTPase RsgA; Reviewed; Region: PRK01889 134676004550 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 134676004551 GTPase/Zn-binding domain interface [polypeptide binding]; other site 134676004552 GTP/Mg2+ binding site [chemical binding]; other site 134676004553 G4 box; other site 134676004554 G5 box; other site 134676004555 G1 box; other site 134676004556 Switch I region; other site 134676004557 G2 box; other site 134676004558 G3 box; other site 134676004559 Switch II region; other site 134676004560 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 134676004561 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 134676004562 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 134676004563 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 134676004564 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 134676004565 iron-sulfur cluster [ion binding]; other site 134676004566 [2Fe-2S] cluster binding site [ion binding]; other site 134676004567 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 134676004568 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 134676004569 GIY-YIG motif/motif A; other site 134676004570 active site 134676004571 catalytic site [active] 134676004572 putative DNA binding site [nucleotide binding]; other site 134676004573 metal binding site [ion binding]; metal-binding site 134676004574 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 134676004575 minor groove reading motif; other site 134676004576 Helix-hairpin-helix motif; Region: HHH; pfam00633 134676004577 helix-hairpin-helix signature motif; other site 134676004578 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 134676004579 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 134676004580 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 134676004581 phosphate binding site [ion binding]; other site 134676004582 putative substrate binding pocket [chemical binding]; other site 134676004583 dimer interface [polypeptide binding]; other site 134676004584 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 134676004585 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 134676004586 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 134676004587 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 134676004588 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 134676004589 Phosphoglycerate kinase; Region: PGK; pfam00162 134676004590 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 134676004591 substrate binding site [chemical binding]; other site 134676004592 hinge regions; other site 134676004593 ADP binding site [chemical binding]; other site 134676004594 catalytic site [active] 134676004595 triosephosphate isomerase; Provisional; Region: PRK14567 134676004596 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 134676004597 substrate binding site [chemical binding]; other site 134676004598 dimer interface [polypeptide binding]; other site 134676004599 catalytic triad [active] 134676004600 Preprotein translocase SecG subunit; Region: SecG; cl09123 134676004601 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 134676004602 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 134676004603 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 134676004604 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 134676004605 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 134676004606 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 134676004607 putative active site [active] 134676004608 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 134676004609 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 134676004610 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 134676004611 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 134676004612 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 134676004613 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 134676004614 putative active site [active] 134676004615 catalytic residue [active] 134676004616 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 134676004617 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 134676004618 TPP-binding site [chemical binding]; other site 134676004619 dimer interface [polypeptide binding]; other site 134676004620 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 134676004621 PYR/PP interface [polypeptide binding]; other site 134676004622 dimer interface [polypeptide binding]; other site 134676004623 TPP binding site [chemical binding]; other site 134676004624 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 134676004625 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 134676004626 UbiA prenyltransferase family; Region: UbiA; pfam01040 134676004627 ATP-grasp domain; Region: ATP-grasp_4; cl17255 134676004628 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 134676004629 Predicted transcriptional regulator [Transcription]; Region: COG2345 134676004630 HTH domain; Region: HTH_11; cl17392 134676004631 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 134676004632 FeS assembly protein SufB; Region: sufB; TIGR01980 134676004633 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 134676004634 FeS assembly protein SufD; Region: sufD; TIGR01981 134676004635 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 134676004636 [2Fe-2S] cluster binding site [ion binding]; other site 134676004637 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 134676004638 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 134676004639 Walker A/P-loop; other site 134676004640 ATP binding site [chemical binding]; other site 134676004641 Q-loop/lid; other site 134676004642 ABC transporter signature motif; other site 134676004643 Walker B; other site 134676004644 D-loop; other site 134676004645 H-loop/switch region; other site 134676004646 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 134676004647 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 134676004648 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 134676004649 catalytic residue [active] 134676004650 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 134676004651 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 134676004652 trimerization site [polypeptide binding]; other site 134676004653 active site 134676004654 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 134676004655 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 134676004656 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 134676004657 SCP-2 sterol transfer family; Region: SCP2; pfam02036 134676004658 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 134676004659 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 134676004660 catalytic core [active] 134676004661 H+ Antiporter protein; Region: 2A0121; TIGR00900 134676004662 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 134676004663 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 134676004664 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 134676004665 active site 134676004666 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 134676004667 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 134676004668 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 134676004669 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 134676004670 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 134676004671 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 134676004672 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 134676004673 substrate binding site [chemical binding]; other site 134676004674 oxyanion hole (OAH) forming residues; other site 134676004675 trimer interface [polypeptide binding]; other site 134676004676 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 134676004677 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 134676004678 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 134676004679 Walker A/P-loop; other site 134676004680 ATP binding site [chemical binding]; other site 134676004681 Q-loop/lid; other site 134676004682 ABC transporter signature motif; other site 134676004683 Walker B; other site 134676004684 D-loop; other site 134676004685 H-loop/switch region; other site 134676004686 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 134676004687 active site 134676004688 SUMO-1 interface [polypeptide binding]; other site 134676004689 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 134676004690 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 134676004691 NAD(P) binding site [chemical binding]; other site 134676004692 active site 134676004693 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 134676004694 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 134676004695 non-specific DNA binding site [nucleotide binding]; other site 134676004696 salt bridge; other site 134676004697 sequence-specific DNA binding site [nucleotide binding]; other site 134676004698 SnoaL-like domain; Region: SnoaL_2; pfam12680 134676004699 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 134676004700 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676004701 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 134676004702 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 134676004703 motif II; other site 134676004704 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 134676004705 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 134676004706 NAD(P) binding site [chemical binding]; other site 134676004707 active site 134676004708 RIO kinase family, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside...; Region: RIO; cl17248 134676004709 ATP binding site [chemical binding]; other site 134676004710 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 134676004711 aconitate hydratase; Validated; Region: PRK09277 134676004712 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 134676004713 substrate binding site [chemical binding]; other site 134676004714 ligand binding site [chemical binding]; other site 134676004715 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 134676004716 substrate binding site [chemical binding]; other site 134676004717 proline aminopeptidase P II; Provisional; Region: PRK10879 134676004718 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 134676004719 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 134676004720 active site 134676004721 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 134676004722 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 134676004723 substrate binding site [chemical binding]; other site 134676004724 ATP binding site [chemical binding]; other site 134676004725 Predicted thioesterase [General function prediction only]; Region: COG5496 134676004726 Bacterial PH domain; Region: DUF304; pfam03703 134676004727 Bacterial PH domain; Region: DUF304; pfam03703 134676004728 Uncharacterized conserved protein [Function unknown]; Region: COG3402 134676004729 MoxR-like ATPases [General function prediction only]; Region: COG0714 134676004730 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 134676004731 Walker A motif; other site 134676004732 ATP binding site [chemical binding]; other site 134676004733 Walker B motif; other site 134676004734 arginine finger; other site 134676004735 Protein of unknown function DUF58; Region: DUF58; pfam01882 134676004736 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 134676004737 von Willebrand factor type A domain; Region: VWA_2; pfam13519 134676004738 metal ion-dependent adhesion site (MIDAS); other site 134676004739 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 134676004740 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676004741 active site 134676004742 phosphorylation site [posttranslational modification] 134676004743 intermolecular recognition site; other site 134676004744 dimerization interface [polypeptide binding]; other site 134676004745 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 134676004746 DNA binding residues [nucleotide binding] 134676004747 dimerization interface [polypeptide binding]; other site 134676004748 Histidine kinase; Region: HisKA_3; pfam07730 134676004749 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 134676004750 Mg2+ binding site [ion binding]; other site 134676004751 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 134676004752 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 134676004753 NAD(P) binding site [chemical binding]; other site 134676004754 homotetramer interface [polypeptide binding]; other site 134676004755 homodimer interface [polypeptide binding]; other site 134676004756 active site 134676004757 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 134676004758 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 134676004759 NAD binding site [chemical binding]; other site 134676004760 homotetramer interface [polypeptide binding]; other site 134676004761 homodimer interface [polypeptide binding]; other site 134676004762 substrate binding site [chemical binding]; other site 134676004763 active site 134676004764 ferrochelatase; Reviewed; Region: hemH; PRK00035 134676004765 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 134676004766 C-terminal domain interface [polypeptide binding]; other site 134676004767 active site 134676004768 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 134676004769 active site 134676004770 N-terminal domain interface [polypeptide binding]; other site 134676004771 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 134676004772 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 134676004773 active site 134676004774 motif I; other site 134676004775 motif II; other site 134676004776 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 134676004777 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 134676004778 Catalytic site [active] 134676004779 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 134676004780 nudix motif; other site 134676004781 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 134676004782 nudix motif; other site 134676004783 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 134676004784 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 134676004785 nudix motif; other site 134676004786 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 134676004787 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 134676004788 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 134676004789 DNA-binding site [nucleotide binding]; DNA binding site 134676004790 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 134676004791 pyridoxal 5'-phosphate binding site [chemical binding]; other site 134676004792 homodimer interface [polypeptide binding]; other site 134676004793 catalytic residue [active] 134676004794 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 134676004795 Beta-lactamase; Region: Beta-lactamase; pfam00144 134676004796 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 134676004797 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 134676004798 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 134676004799 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 134676004800 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 134676004801 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 134676004802 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 134676004803 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 134676004804 heme-binding site [chemical binding]; other site 134676004805 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 134676004806 FAD binding pocket [chemical binding]; other site 134676004807 conserved FAD binding motif [chemical binding]; other site 134676004808 phosphate binding motif [ion binding]; other site 134676004809 beta-alpha-beta structure motif; other site 134676004810 NAD binding pocket [chemical binding]; other site 134676004811 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 134676004812 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK04690 134676004813 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 134676004814 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 134676004815 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 134676004816 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 134676004817 putative active site [active] 134676004818 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 134676004819 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 134676004820 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 134676004821 putative PBP binding loops; other site 134676004822 dimer interface [polypeptide binding]; other site 134676004823 ABC-ATPase subunit interface; other site 134676004824 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 134676004825 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 134676004826 ABC-ATPase subunit interface; other site 134676004827 putative PBP binding loops; other site 134676004828 carbohydrate ABC transporter, N-acetylglucosamine/diacetylchitobiose-binding protein; Region: chitin_NgcE; TIGR03851 134676004829 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 134676004830 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 134676004831 dimer interface [polypeptide binding]; other site 134676004832 conserved gate region; other site 134676004833 putative PBP binding loops; other site 134676004834 ABC-ATPase subunit interface; other site 134676004835 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 134676004836 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 134676004837 dimer interface [polypeptide binding]; other site 134676004838 conserved gate region; other site 134676004839 putative PBP binding loops; other site 134676004840 ABC-ATPase subunit interface; other site 134676004841 bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975 134676004842 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cd06444 134676004843 active site 134676004844 DNA binding site [nucleotide binding] 134676004845 catalytic site [active] 134676004846 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 134676004847 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 134676004848 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 134676004849 substrate binding pocket [chemical binding]; other site 134676004850 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 134676004851 B12 binding site [chemical binding]; other site 134676004852 cobalt ligand [ion binding]; other site 134676004853 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 134676004854 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 134676004855 ATP-binding site [chemical binding]; other site 134676004856 Gluconate-6-phosphate binding site [chemical binding]; other site 134676004857 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 134676004858 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676004859 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 134676004860 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 134676004861 Histidine kinase; Region: HisKA_3; pfam07730 134676004862 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 134676004863 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 134676004864 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676004865 active site 134676004866 phosphorylation site [posttranslational modification] 134676004867 intermolecular recognition site; other site 134676004868 dimerization interface [polypeptide binding]; other site 134676004869 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 134676004870 DNA binding residues [nucleotide binding] 134676004871 dimerization interface [polypeptide binding]; other site 134676004872 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 134676004873 nudix motif; other site 134676004874 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 134676004875 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676004876 metal binding site [ion binding]; metal-binding site 134676004877 active site 134676004878 I-site; other site 134676004879 Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439 134676004880 glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561 134676004881 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 134676004882 Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200 134676004883 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 134676004884 catalytic residues [active] 134676004885 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 134676004886 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 134676004887 Glutamine amidotransferase class-I; Region: GATase; pfam00117 134676004888 glutamine binding [chemical binding]; other site 134676004889 catalytic triad [active] 134676004890 phosphoglycerate mutase; Provisional; Region: PTZ00122 134676004891 Response regulator receiver domain; Region: Response_reg; pfam00072 134676004892 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676004893 active site 134676004894 phosphorylation site [posttranslational modification] 134676004895 intermolecular recognition site; other site 134676004896 dimerization interface [polypeptide binding]; other site 134676004897 Predicted transcriptional regulators [Transcription]; Region: COG1695 134676004898 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 134676004899 LabA_like proteins; Region: LabA_like; cd06167 134676004900 putative metal binding site [ion binding]; other site 134676004901 hypothetical protein; Provisional; Region: PRK11770 134676004902 Domain of unknown function (DUF307); Region: DUF307; pfam03733 134676004903 Domain of unknown function (DUF307); Region: DUF307; pfam03733 134676004904 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 134676004905 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 134676004906 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 134676004907 Walker A motif; other site 134676004908 ATP binding site [chemical binding]; other site 134676004909 Walker B motif; other site 134676004910 arginine finger; other site 134676004911 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 134676004912 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 134676004913 phosphate binding site [ion binding]; other site 134676004914 DNA polymerase IV; Provisional; Region: PRK03348 134676004915 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 134676004916 active site 134676004917 DNA binding site [nucleotide binding] 134676004918 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 134676004919 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 134676004920 D-pathway; other site 134676004921 Putative ubiquinol binding site [chemical binding]; other site 134676004922 Low-spin heme (heme b) binding site [chemical binding]; other site 134676004923 Putative water exit pathway; other site 134676004924 Binuclear center (heme o3/CuB) [ion binding]; other site 134676004925 K-pathway; other site 134676004926 Putative proton exit pathway; other site 134676004927 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 134676004928 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676004929 SdpI/YhfL protein family; Region: SdpI; pfam13630 134676004930 GtrA-like protein; Region: GtrA; pfam04138 134676004931 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 134676004932 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676004933 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 134676004934 extended (e) SDRs; Region: SDR_e; cd08946 134676004935 NAD(P) binding site [chemical binding]; other site 134676004936 active site 134676004937 substrate binding site [chemical binding]; other site 134676004938 Cytochrome P450; Region: p450; cl12078 134676004939 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 134676004940 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 134676004941 active site 134676004942 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 134676004943 AMP-binding enzyme; Region: AMP-binding; pfam00501 134676004944 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 134676004945 acyl-activating enzyme (AAE) consensus motif; other site 134676004946 AMP binding site [chemical binding]; other site 134676004947 active site 134676004948 CoA binding site [chemical binding]; other site 134676004949 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 134676004950 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 134676004951 active site 134676004952 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 134676004953 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 134676004954 active site 134676004955 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 134676004956 Catalytic domain of Protein Kinases; Region: PKc; cd00180 134676004957 active site 134676004958 ATP binding site [chemical binding]; other site 134676004959 substrate binding site [chemical binding]; other site 134676004960 activation loop (A-loop); other site 134676004961 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 134676004962 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676004963 Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042 134676004964 Lamin Tail Domain; Region: LTD; pfam00932 134676004965 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 134676004966 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 134676004967 putative NAD(P) binding site [chemical binding]; other site 134676004968 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 134676004969 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676004970 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 134676004971 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 134676004972 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 134676004973 Domain of unknown function DUF21; Region: DUF21; pfam01595 134676004974 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 134676004975 Transporter associated domain; Region: CorC_HlyC; smart01091 134676004976 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 134676004977 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 134676004978 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 134676004979 dimer interface [polypeptide binding]; other site 134676004980 putative CheW interface [polypeptide binding]; other site 134676004981 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 134676004982 Asp-box motif; other site 134676004983 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 134676004984 Tetratricopeptide repeat; Region: TPR_12; pfam13424 134676004985 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 134676004986 TPR motif; other site 134676004987 binding surface 134676004988 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 134676004989 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676004990 metal binding site [ion binding]; metal-binding site 134676004991 active site 134676004992 I-site; other site 134676004993 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 134676004994 putative active site [active] 134676004995 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 134676004996 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 134676004997 NAD(P) binding site [chemical binding]; other site 134676004998 active site 134676004999 hypothetical protein; Provisional; Region: PRK06547 134676005000 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 134676005001 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 134676005002 putative molybdopterin cofactor binding site [chemical binding]; other site 134676005003 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 134676005004 putative molybdopterin cofactor binding site; other site 134676005005 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 134676005006 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 134676005007 dimer interface [polypeptide binding]; other site 134676005008 conserved gate region; other site 134676005009 putative PBP binding loops; other site 134676005010 ABC-ATPase subunit interface; other site 134676005011 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 134676005012 dimer interface [polypeptide binding]; other site 134676005013 conserved gate region; other site 134676005014 putative PBP binding loops; other site 134676005015 ABC-ATPase subunit interface; other site 134676005016 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 134676005017 CHASE domain; Region: CHASE; cl01369 134676005018 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 134676005019 PAS domain; Region: PAS; smart00091 134676005020 putative active site [active] 134676005021 heme pocket [chemical binding]; other site 134676005022 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 134676005023 dimer interface [polypeptide binding]; other site 134676005024 phosphorylation site [posttranslational modification] 134676005025 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676005026 ATP binding site [chemical binding]; other site 134676005027 Mg2+ binding site [ion binding]; other site 134676005028 G-X-G motif; other site 134676005029 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 134676005030 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 134676005031 dimer interface [polypeptide binding]; other site 134676005032 phosphorylation site [posttranslational modification] 134676005033 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676005034 ATP binding site [chemical binding]; other site 134676005035 Mg2+ binding site [ion binding]; other site 134676005036 G-X-G motif; other site 134676005037 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 134676005038 GAF domain; Region: GAF; pfam01590 134676005039 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 134676005040 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 134676005041 dimer interface [polypeptide binding]; other site 134676005042 phosphorylation site [posttranslational modification] 134676005043 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676005044 ATP binding site [chemical binding]; other site 134676005045 Mg2+ binding site [ion binding]; other site 134676005046 G-X-G motif; other site 134676005047 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 134676005048 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 134676005049 tetramer interface [polypeptide binding]; other site 134676005050 active site 134676005051 Mg2+/Mn2+ binding site [ion binding]; other site 134676005052 GAF domain; Region: GAF; pfam01590 134676005053 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 134676005054 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 134676005055 PAS domain; Region: PAS_9; pfam13426 134676005056 putative active site [active] 134676005057 heme pocket [chemical binding]; other site 134676005058 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 134676005059 PAS domain; Region: PAS_9; pfam13426 134676005060 putative active site [active] 134676005061 heme pocket [chemical binding]; other site 134676005062 PAS domain S-box; Region: sensory_box; TIGR00229 134676005063 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 134676005064 putative active site [active] 134676005065 heme pocket [chemical binding]; other site 134676005066 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 134676005067 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 134676005068 dimer interface [polypeptide binding]; other site 134676005069 phosphorylation site [posttranslational modification] 134676005070 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676005071 ATP binding site [chemical binding]; other site 134676005072 Mg2+ binding site [ion binding]; other site 134676005073 G-X-G motif; other site 134676005074 hypothetical protein; Provisional; Region: PRK07236 134676005075 FAD binding domain; Region: FAD_binding_3; pfam01494 134676005076 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676005077 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 134676005078 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 134676005079 GAF domain; Region: GAF; pfam01590 134676005080 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 134676005081 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 134676005082 dimer interface [polypeptide binding]; other site 134676005083 phosphorylation site [posttranslational modification] 134676005084 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676005085 ATP binding site [chemical binding]; other site 134676005086 Mg2+ binding site [ion binding]; other site 134676005087 G-X-G motif; other site 134676005088 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 134676005089 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 134676005090 ligand binding site [chemical binding]; other site 134676005091 flexible hinge region; other site 134676005092 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 134676005093 substrate binding pocket [chemical binding]; other site 134676005094 substrate-Mg2+ binding site; other site 134676005095 aspartate-rich region 1; other site 134676005096 aspartate-rich region 2; other site 134676005097 tocopherol O-methyltransferase; Region: PLN02244 134676005098 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 134676005099 S-adenosylmethionine binding site [chemical binding]; other site 134676005100 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 134676005101 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 134676005102 Excalibur calcium-binding domain; Region: Excalibur; cl05460 134676005103 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 134676005104 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 134676005105 active site 134676005106 catalytic tetrad [active] 134676005107 CHAT domain; Region: CHAT; cl17868 134676005108 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_1; cd11347 134676005109 active site 134676005110 catalytic site [active] 134676005111 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 134676005112 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 134676005113 Biofilm formation and stress response factor; Region: BsmA; pfam10014 134676005114 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 134676005115 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 134676005116 inhibitor site; inhibition site 134676005117 active site 134676005118 dimer interface [polypeptide binding]; other site 134676005119 catalytic residue [active] 134676005120 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 134676005121 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 134676005122 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 134676005123 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 134676005124 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 134676005125 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 134676005126 putative ligand binding site [chemical binding]; other site 134676005127 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 134676005128 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 134676005129 Walker A/P-loop; other site 134676005130 ATP binding site [chemical binding]; other site 134676005131 Q-loop/lid; other site 134676005132 ABC transporter signature motif; other site 134676005133 Walker B; other site 134676005134 D-loop; other site 134676005135 H-loop/switch region; other site 134676005136 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 134676005137 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 134676005138 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 134676005139 TM-ABC transporter signature motif; other site 134676005140 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 134676005141 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 134676005142 TM-ABC transporter signature motif; other site 134676005143 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 134676005144 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 134676005145 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 134676005146 MarR family; Region: MarR_2; cl17246 134676005147 Pyruvoyl-dependent arginine decarboxylase (PvlArgDC); Region: PvlArgDC; cl00849 134676005148 Rdx family; Region: Rdx; cl01407 134676005149 Transcriptional regulator [Transcription]; Region: LytR; COG1316 134676005150 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 134676005151 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 134676005152 active site 134676005153 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_7; cd05844 134676005154 putative ADP-binding pocket [chemical binding]; other site 134676005155 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 134676005156 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 134676005157 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 134676005158 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 134676005159 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 134676005160 Predicted membrane protein (DUF2127); Region: DUF2127; cl01785 134676005161 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 134676005162 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 134676005163 Predicted transcriptional regulators [Transcription]; Region: COG1378 134676005164 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 134676005165 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 134676005166 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 134676005167 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 134676005168 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 134676005169 Catalytic domain of Protein Kinases; Region: PKc; cd00180 134676005170 active site 134676005171 ATP binding site [chemical binding]; other site 134676005172 substrate binding site [chemical binding]; other site 134676005173 activation loop (A-loop); other site 134676005174 AAA ATPase domain; Region: AAA_16; pfam13191 134676005175 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 134676005176 TPR motif; other site 134676005177 binding surface 134676005178 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 134676005179 GAF domain; Region: GAF_3; pfam13492 134676005180 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 134676005181 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676005182 metal binding site [ion binding]; metal-binding site 134676005183 active site 134676005184 I-site; other site 134676005185 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 134676005186 RDD family; Region: RDD; pfam06271 134676005187 Nitronate monooxygenase; Region: NMO; pfam03060 134676005188 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 134676005189 FMN binding site [chemical binding]; other site 134676005190 substrate binding site [chemical binding]; other site 134676005191 putative catalytic residue [active] 134676005192 fumarylacetoacetase; Region: PLN02856 134676005193 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 134676005194 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 134676005195 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 134676005196 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 134676005197 aminotransferase; Validated; Region: PRK07337 134676005198 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 134676005199 pyridoxal 5'-phosphate binding site [chemical binding]; other site 134676005200 homodimer interface [polypeptide binding]; other site 134676005201 catalytic residue [active] 134676005202 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 134676005203 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 134676005204 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 134676005205 NodB motif; other site 134676005206 active site 134676005207 catalytic site [active] 134676005208 metal binding site [ion binding]; metal-binding site 134676005209 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 134676005210 TAP-like protein; Region: Abhydrolase_4; pfam08386 134676005211 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 134676005212 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 134676005213 active site 134676005214 catalytic tetrad [active] 134676005215 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 134676005216 salt bridge; other site 134676005217 non-specific DNA binding site [nucleotide binding]; other site 134676005218 sequence-specific DNA binding site [nucleotide binding]; other site 134676005219 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 134676005220 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 134676005221 substrate binding pocket [chemical binding]; other site 134676005222 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 134676005223 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 134676005224 active site 134676005225 catalytic triad [active] 134676005226 oxyanion hole [active] 134676005227 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 134676005228 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 134676005229 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 134676005230 putative active site [active] 134676005231 putative substrate binding site [chemical binding]; other site 134676005232 putative cosubstrate binding site; other site 134676005233 catalytic site [active] 134676005234 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 134676005235 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 134676005236 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 134676005237 DivIVA protein; Region: DivIVA; pfam05103 134676005238 DivIVA domain; Region: DivI1A_domain; TIGR03544 134676005239 Protein of unknown function (DUF3455); Region: DUF3455; pfam11937 134676005240 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 134676005241 active site 134676005242 metal binding site [ion binding]; metal-binding site 134676005243 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 134676005244 putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055 134676005245 FeS/SAM binding site; other site 134676005246 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 134676005247 PAS domain S-box; Region: sensory_box; TIGR00229 134676005248 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 134676005249 putative active site [active] 134676005250 heme pocket [chemical binding]; other site 134676005251 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 134676005252 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 134676005253 dimer interface [polypeptide binding]; other site 134676005254 phosphorylation site [posttranslational modification] 134676005255 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676005256 ATP binding site [chemical binding]; other site 134676005257 Mg2+ binding site [ion binding]; other site 134676005258 G-X-G motif; other site 134676005259 Response regulator receiver domain; Region: Response_reg; pfam00072 134676005260 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676005261 active site 134676005262 phosphorylation site [posttranslational modification] 134676005263 intermolecular recognition site; other site 134676005264 dimerization interface [polypeptide binding]; other site 134676005265 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830 134676005266 active site 134676005267 catalytic triad [active] 134676005268 oxyanion hole [active] 134676005269 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 134676005270 Major Facilitator Superfamily; Region: MFS_1; pfam07690 134676005271 putative substrate translocation pore; other site 134676005272 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 134676005273 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 134676005274 Q-X-W motif; other site 134676005275 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 134676005276 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 134676005277 anti sigma factor interaction site; other site 134676005278 regulatory phosphorylation site [posttranslational modification]; other site 134676005279 ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones]; Region: RPT1; COG1222 134676005280 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 134676005281 Walker A motif; other site 134676005282 ATP binding site [chemical binding]; other site 134676005283 Walker B motif; other site 134676005284 Peptidase family M41; Region: Peptidase_M41; pfam01434 134676005285 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 134676005286 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 134676005287 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676005288 metal binding site [ion binding]; metal-binding site 134676005289 active site 134676005290 I-site; other site 134676005291 Peptidase family M23; Region: Peptidase_M23; pfam01551 134676005292 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 134676005293 Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116 134676005294 PLD-like domain; Region: PLDc_2; pfam13091 134676005295 putative active site [active] 134676005296 catalytic site [active] 134676005297 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 134676005298 PLD-like domain; Region: PLDc_2; pfam13091 134676005299 putative active site [active] 134676005300 catalytic site [active] 134676005301 Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783 134676005302 DNA binding residues [nucleotide binding] 134676005303 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 134676005304 dimer interface [polypeptide binding]; other site 134676005305 mercury binding site [ion binding]; other site 134676005306 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 134676005307 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 134676005308 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 134676005309 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 134676005310 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 134676005311 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 134676005312 The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762 134676005313 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 134676005314 putative [Fe4-S4] binding site [ion binding]; other site 134676005315 putative molybdopterin cofactor binding site [chemical binding]; other site 134676005316 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 134676005317 putative molybdopterin cofactor binding site; other site 134676005318 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 134676005319 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 134676005320 nucleophile elbow; other site 134676005321 Predicted transcriptional regulators [Transcription]; Region: COG1695 134676005322 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 134676005323 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 134676005324 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 134676005325 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 134676005326 active site 134676005327 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 134676005328 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 134676005329 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 134676005330 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 134676005331 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 134676005332 active site 134676005333 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 134676005334 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 134676005335 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 134676005336 ATP-grasp domain; Region: ATP-grasp_4; cl17255 134676005337 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 134676005338 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 134676005339 carboxyltransferase (CT) interaction site; other site 134676005340 biotinylation site [posttranslational modification]; other site 134676005341 Acetyl-CoA carboxylase, central region; Region: ACC_central; pfam08326 134676005342 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 134676005343 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 134676005344 active site 134676005345 Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231 134676005346 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 134676005347 sugar binding site [chemical binding]; other site 134676005348 Nitrate and nitrite sensing; Region: NIT; pfam08376 134676005349 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676005350 ATP binding site [chemical binding]; other site 134676005351 Mg2+ binding site [ion binding]; other site 134676005352 G-X-G motif; other site 134676005353 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 134676005354 Protein of unknown function (DUF742); Region: DUF742; pfam05331 134676005355 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 134676005356 G2 box; other site 134676005357 Switch I region; other site 134676005358 G3 box; other site 134676005359 Switch II region; other site 134676005360 GTP/Mg2+ binding site [chemical binding]; other site 134676005361 G4 box; other site 134676005362 G5 box; other site 134676005363 Part of AAA domain; Region: AAA_19; pfam13245 134676005364 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 134676005365 AAA domain; Region: AAA_12; pfam13087 134676005366 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 134676005367 uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_2; cd07805 134676005368 N- and C-terminal domain interface [polypeptide binding]; other site 134676005369 active site 134676005370 MgATP binding site [chemical binding]; other site 134676005371 catalytic site [active] 134676005372 metal binding site [ion binding]; metal-binding site 134676005373 xylulose binding site [chemical binding]; other site 134676005374 putative homodimer interface [polypeptide binding]; other site 134676005375 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 134676005376 intersubunit interface [polypeptide binding]; other site 134676005377 active site 134676005378 Zn2+ binding site [ion binding]; other site 134676005379 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 134676005380 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 134676005381 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 134676005382 catalytic residue [active] 134676005383 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 134676005384 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 134676005385 Cytochrome P450; Region: p450; cl12078 134676005386 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 134676005387 Cellulose binding domain; Region: CBM_2; pfam00553 134676005388 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 134676005389 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 134676005390 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 134676005391 heme binding site [chemical binding]; other site 134676005392 ferroxidase pore; other site 134676005393 ferroxidase diiron center [ion binding]; other site 134676005394 LexA repressor; Validated; Region: PRK00215 134676005395 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 134676005396 putative DNA binding site [nucleotide binding]; other site 134676005397 putative Zn2+ binding site [ion binding]; other site 134676005398 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 134676005399 Catalytic site [active] 134676005400 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 134676005401 catalytic residue [active] 134676005402 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 134676005403 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 134676005404 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 134676005405 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 134676005406 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 134676005407 dimer interface [polypeptide binding]; other site 134676005408 conserved gate region; other site 134676005409 putative PBP binding loops; other site 134676005410 ABC-ATPase subunit interface; other site 134676005411 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 134676005412 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 134676005413 dimer interface [polypeptide binding]; other site 134676005414 conserved gate region; other site 134676005415 putative PBP binding loops; other site 134676005416 ABC-ATPase subunit interface; other site 134676005417 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 134676005418 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 134676005419 NAD binding site [chemical binding]; other site 134676005420 sugar binding site [chemical binding]; other site 134676005421 divalent metal binding site [ion binding]; other site 134676005422 tetramer (dimer of dimers) interface [polypeptide binding]; other site 134676005423 dimer interface [polypeptide binding]; other site 134676005424 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 134676005425 Major Facilitator Superfamily; Region: MFS_1; pfam07690 134676005426 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 134676005427 putative DNA binding site [nucleotide binding]; other site 134676005428 putative Zn2+ binding site [ion binding]; other site 134676005429 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 134676005430 active site 134676005431 Zn binding site [ion binding]; other site 134676005432 CHASE3 domain; Region: CHASE3; pfam05227 134676005433 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 134676005434 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 134676005435 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 134676005436 dimer interface [polypeptide binding]; other site 134676005437 putative CheW interface [polypeptide binding]; other site 134676005438 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 134676005439 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 134676005440 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 134676005441 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 134676005442 sugar binding site [chemical binding]; other site 134676005443 Transcriptional regulators [Transcription]; Region: PurR; COG1609 134676005444 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 134676005445 DNA binding site [nucleotide binding] 134676005446 domain linker motif; other site 134676005447 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 134676005448 dimerization interface [polypeptide binding]; other site 134676005449 ligand binding site [chemical binding]; other site 134676005450 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 134676005451 homotetramer interface [polypeptide binding]; other site 134676005452 active site 134676005453 metal binding site [ion binding]; metal-binding site 134676005454 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 134676005455 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 134676005456 NAD(P) binding site [chemical binding]; other site 134676005457 PAS fold; Region: PAS_4; pfam08448 134676005458 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 134676005459 putative active site [active] 134676005460 heme pocket [chemical binding]; other site 134676005461 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 134676005462 PAS fold; Region: PAS_3; pfam08447 134676005463 putative active site [active] 134676005464 heme pocket [chemical binding]; other site 134676005465 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 134676005466 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 134676005467 dimer interface [polypeptide binding]; other site 134676005468 phosphorylation site [posttranslational modification] 134676005469 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676005470 ATP binding site [chemical binding]; other site 134676005471 Mg2+ binding site [ion binding]; other site 134676005472 G-X-G motif; other site 134676005473 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 134676005474 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676005475 active site 134676005476 phosphorylation site [posttranslational modification] 134676005477 intermolecular recognition site; other site 134676005478 dimerization interface [polypeptide binding]; other site 134676005479 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 134676005480 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 134676005481 NodB motif; other site 134676005482 active site 134676005483 catalytic site [active] 134676005484 metal binding site [ion binding]; metal-binding site 134676005485 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 134676005486 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 134676005487 Zn binding site [ion binding]; other site 134676005488 choline dehydrogenase; Validated; Region: PRK02106 134676005489 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 134676005490 DDE superfamily endonuclease; Region: DDE_5; cl17874 134676005491 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 134676005492 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 134676005493 active site 134676005494 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 134676005495 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 134676005496 NAD(P) binding site [chemical binding]; other site 134676005497 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 134676005498 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 134676005499 active site 134676005500 homotetramer interface [polypeptide binding]; other site 134676005501 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 134676005502 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 134676005503 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 134676005504 CGNR zinc finger; Region: zf-CGNR; pfam11706 134676005505 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 134676005506 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 134676005507 putative substrate translocation pore; other site 134676005508 short chain dehydrogenase; Provisional; Region: PRK08263 134676005509 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 134676005510 NADP binding site [chemical binding]; other site 134676005511 active site 134676005512 steroid binding site; other site 134676005513 H+ Antiporter protein; Region: 2A0121; TIGR00900 134676005514 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 134676005515 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 134676005516 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 134676005517 Cytochrome P450; Region: p450; cl12078 134676005518 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 134676005519 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 134676005520 active site 134676005521 substrate binding site [chemical binding]; other site 134676005522 FMN binding site [chemical binding]; other site 134676005523 putative catalytic residues [active] 134676005524 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 134676005525 substrate binding pocket [chemical binding]; other site 134676005526 active site 134676005527 iron coordination sites [ion binding]; other site 134676005528 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 134676005529 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 134676005530 dimer interface [polypeptide binding]; other site 134676005531 conserved gate region; other site 134676005532 putative PBP binding loops; other site 134676005533 ABC-ATPase subunit interface; other site 134676005534 nickel transporter permease NikC; Provisional; Region: nikC; PRK10417 134676005535 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 134676005536 dimer interface [polypeptide binding]; other site 134676005537 conserved gate region; other site 134676005538 putative PBP binding loops; other site 134676005539 ABC-ATPase subunit interface; other site 134676005540 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 134676005541 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 134676005542 Walker A/P-loop; other site 134676005543 ATP binding site [chemical binding]; other site 134676005544 Q-loop/lid; other site 134676005545 ABC transporter signature motif; other site 134676005546 Walker B; other site 134676005547 D-loop; other site 134676005548 H-loop/switch region; other site 134676005549 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 134676005550 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 134676005551 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 134676005552 Walker A/P-loop; other site 134676005553 ATP binding site [chemical binding]; other site 134676005554 Q-loop/lid; other site 134676005555 ABC transporter signature motif; other site 134676005556 Walker B; other site 134676005557 D-loop; other site 134676005558 H-loop/switch region; other site 134676005559 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 134676005560 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 134676005561 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 134676005562 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 134676005563 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 134676005564 putative active site [active] 134676005565 heme pocket [chemical binding]; other site 134676005566 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676005567 ATP binding site [chemical binding]; other site 134676005568 Mg2+ binding site [ion binding]; other site 134676005569 G-X-G motif; other site 134676005570 Response regulator receiver domain; Region: Response_reg; pfam00072 134676005571 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676005572 active site 134676005573 phosphorylation site [posttranslational modification] 134676005574 intermolecular recognition site; other site 134676005575 dimerization interface [polypeptide binding]; other site 134676005576 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 134676005577 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676005578 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 134676005579 HAMP domain; Region: HAMP; pfam00672 134676005580 dimerization interface [polypeptide binding]; other site 134676005581 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 134676005582 dimer interface [polypeptide binding]; other site 134676005583 putative CheW interface [polypeptide binding]; other site 134676005584 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 134676005585 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 134676005586 putative substrate translocation pore; other site 134676005587 MarR family; Region: MarR_2; cl17246 134676005588 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 134676005589 Old yellow enzyme (OYE)-related FMN binding domain, group 5. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747 134676005590 putative active site [active] 134676005591 putative FMN binding site [chemical binding]; other site 134676005592 putative substrate binding site [chemical binding]; other site 134676005593 putative catalytic residue [active] 134676005594 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 134676005595 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676005596 active site 134676005597 phosphorylation site [posttranslational modification] 134676005598 intermolecular recognition site; other site 134676005599 dimerization interface [polypeptide binding]; other site 134676005600 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 134676005601 DNA binding residues [nucleotide binding] 134676005602 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 134676005603 Histidine kinase; Region: HisKA_3; pfam07730 134676005604 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 134676005605 PilZ domain; Region: PilZ; pfam07238 134676005606 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 134676005607 putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027 134676005608 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 134676005609 Predicted membrane protein [Function unknown]; Region: COG3463 134676005610 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 134676005611 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676005612 active site 134676005613 phosphorylation site [posttranslational modification] 134676005614 intermolecular recognition site; other site 134676005615 dimerization interface [polypeptide binding]; other site 134676005616 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 134676005617 DNA binding site [nucleotide binding] 134676005618 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 134676005619 HAMP domain; Region: HAMP; pfam00672 134676005620 dimerization interface [polypeptide binding]; other site 134676005621 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 134676005622 dimer interface [polypeptide binding]; other site 134676005623 phosphorylation site [posttranslational modification] 134676005624 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676005625 ATP binding site [chemical binding]; other site 134676005626 Mg2+ binding site [ion binding]; other site 134676005627 G-X-G motif; other site 134676005628 Predicted transcriptional regulators [Transcription]; Region: COG1695 134676005629 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 134676005630 Ribosomal protein S27; Region: Ribosomal_S27e; cl00897 134676005631 phage tail protein domain; Region: tail_TIGR02242 134676005632 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 134676005633 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 134676005634 PAAR motif; Region: PAAR_motif; cl15808 134676005635 PAAR motif; Region: PAAR_motif; pfam05488 134676005636 Phage protein D [General function prediction only]; Region: COG3500 134676005637 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 134676005638 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 134676005639 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 134676005640 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 134676005641 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 134676005642 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 134676005643 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 134676005644 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 134676005645 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 134676005646 Walker A motif; other site 134676005647 ATP binding site [chemical binding]; other site 134676005648 Walker B motif; other site 134676005649 arginine finger; other site 134676005650 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 134676005651 nucleotide binding site [chemical binding]; other site 134676005652 MoxR-like ATPases [General function prediction only]; Region: COG0714 134676005653 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 134676005654 Walker A motif; other site 134676005655 ATP binding site [chemical binding]; other site 134676005656 Walker B motif; other site 134676005657 arginine finger; other site 134676005658 CARDB; Region: CARDB; pfam07705 134676005659 Protein of unknown function DUF58; Region: DUF58; pfam01882 134676005660 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 134676005661 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 134676005662 PKD domain; Region: PKD; pfam00801 134676005663 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 134676005664 hydrophobic ligand binding site; other site 134676005665 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 134676005666 Domain of unknown function (DUF397); Region: DUF397; pfam04149 134676005667 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075 134676005668 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 134676005669 Protein of unknown function DUF262; Region: DUF262; pfam03235 134676005670 Uncharacterized conserved protein [Function unknown]; Region: COG1479 134676005671 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 134676005672 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 134676005673 dimerization interface [polypeptide binding]; other site 134676005674 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676005675 Mg2+ binding site [ion binding]; other site 134676005676 G-X-G motif; other site 134676005677 Response regulator receiver domain; Region: Response_reg; pfam00072 134676005678 Response regulator receiver domain; Region: Response_reg; pfam00072 134676005679 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676005680 active site 134676005681 phosphorylation site [posttranslational modification] 134676005682 intermolecular recognition site; other site 134676005683 dimerization interface [polypeptide binding]; other site 134676005684 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 134676005685 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 134676005686 anti sigma factor interaction site; other site 134676005687 regulatory phosphorylation site [posttranslational modification]; other site 134676005688 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 134676005689 ANTAR domain; Region: ANTAR; cl04297 134676005690 CheB methylesterase; Region: CheB_methylest; pfam01339 134676005691 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 134676005692 anti sigma factor interaction site; other site 134676005693 regulatory phosphorylation site [posttranslational modification]; other site 134676005694 Helix-turn-helix domain; Region: HTH_18; pfam12833 134676005695 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 134676005696 PAS fold; Region: PAS_4; pfam08448 134676005697 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 134676005698 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 134676005699 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 134676005700 ATP binding site [chemical binding]; other site 134676005701 Mg2+ binding site [ion binding]; other site 134676005702 G-X-G motif; other site 134676005703 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 134676005704 anti sigma factor interaction site; other site 134676005705 regulatory phosphorylation site [posttranslational modification]; other site 134676005706 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 134676005707 metal binding site [ion binding]; metal-binding site 134676005708 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 134676005709 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 134676005710 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 134676005711 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 134676005712 DNA binding residues [nucleotide binding] 134676005713 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 134676005714 anti sigma factor interaction site; other site 134676005715 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 134676005716 regulatory phosphorylation site [posttranslational modification]; other site 134676005717 CheB methylesterase; Region: CheB_methylest; pfam01339 134676005718 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 134676005719 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 134676005720 dimer interface [polypeptide binding]; other site 134676005721 phosphorylation site [posttranslational modification] 134676005722 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676005723 ATP binding site [chemical binding]; other site 134676005724 Mg2+ binding site [ion binding]; other site 134676005725 G-X-G motif; other site 134676005726 Response regulator receiver domain; Region: Response_reg; pfam00072 134676005727 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676005728 active site 134676005729 phosphorylation site [posttranslational modification] 134676005730 intermolecular recognition site; other site 134676005731 dimerization interface [polypeptide binding]; other site 134676005732 PAS fold; Region: PAS_4; pfam08448 134676005733 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 134676005734 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 134676005735 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 134676005736 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 134676005737 anti sigma factor interaction site; other site 134676005738 regulatory phosphorylation site [posttranslational modification]; other site 134676005739 Recombinase; Region: Recombinase; pfam07508 134676005740 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 134676005741 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 134676005742 Interdomain contacts; other site 134676005743 Cytokine receptor motif; other site 134676005744 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 134676005745 Interdomain contacts; other site 134676005746 Cytokine receptor motif; other site 134676005747 MoxR-like ATPases [General function prediction only]; Region: COG0714 134676005748 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 134676005749 Walker A motif; other site 134676005750 ATP binding site [chemical binding]; other site 134676005751 Walker B motif; other site 134676005752 arginine finger; other site 134676005753 Protein of unknown function DUF58; Region: DUF58; pfam01882 134676005754 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 134676005755 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 134676005756 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 134676005757 GAF domain; Region: GAF; pfam01590 134676005758 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 134676005759 PAS domain; Region: PAS_9; pfam13426 134676005760 putative active site [active] 134676005761 heme pocket [chemical binding]; other site 134676005762 GAF domain; Region: GAF; pfam01590 134676005763 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 134676005764 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 134676005765 PAS domain; Region: PAS_9; pfam13426 134676005766 putative active site [active] 134676005767 heme pocket [chemical binding]; other site 134676005768 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 134676005769 dimer interface [polypeptide binding]; other site 134676005770 phosphorylation site [posttranslational modification] 134676005771 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676005772 ATP binding site [chemical binding]; other site 134676005773 Mg2+ binding site [ion binding]; other site 134676005774 G-X-G motif; other site 134676005775 CHASE3 domain; Region: CHASE3; pfam05227 134676005776 Response regulator receiver domain; Region: Response_reg; pfam00072 134676005777 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676005778 active site 134676005779 phosphorylation site [posttranslational modification] 134676005780 intermolecular recognition site; other site 134676005781 dimerization interface [polypeptide binding]; other site 134676005782 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 134676005783 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 134676005784 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 134676005785 S-adenosylmethionine binding site [chemical binding]; other site 134676005786 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 134676005787 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 134676005788 putative substrate translocation pore; other site 134676005789 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 134676005790 Zn2+ binding site [ion binding]; other site 134676005791 Mg2+ binding site [ion binding]; other site 134676005792 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 134676005793 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 134676005794 metal binding site [ion binding]; metal-binding site 134676005795 dimer interface [polypeptide binding]; other site 134676005796 Protein of unknown function (DUF1684); Region: DUF1684; pfam07920 134676005797 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 134676005798 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 134676005799 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 134676005800 catalytic residue [active] 134676005801 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 134676005802 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 134676005803 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 134676005804 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 134676005805 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 134676005806 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 134676005807 putative sugar binding sites [chemical binding]; other site 134676005808 Q-X-W motif; other site 134676005809 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 134676005810 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 134676005811 DNA binding residues [nucleotide binding] 134676005812 putative dimer interface [polypeptide binding]; other site 134676005813 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 134676005814 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 134676005815 NAD(P) binding site [chemical binding]; other site 134676005816 active site 134676005817 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_9; cd07826 134676005818 putative hydrophobic ligand binding site [chemical binding]; other site 134676005819 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 134676005820 dimerization interface [polypeptide binding]; other site 134676005821 putative DNA binding site [nucleotide binding]; other site 134676005822 putative Zn2+ binding site [ion binding]; other site 134676005823 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 134676005824 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 134676005825 putative NAD(P) binding site [chemical binding]; other site 134676005826 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 134676005827 Protein of unknown function (DUF664); Region: DUF664; pfam04978 134676005828 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 134676005829 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 134676005830 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 134676005831 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 134676005832 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 134676005833 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 134676005834 PilZ domain; Region: PilZ; pfam07238 134676005835 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 134676005836 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 134676005837 Septum formation; Region: Septum_form; pfam13845 134676005838 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 134676005839 Transcriptional regulators [Transcription]; Region: PurR; COG1609 134676005840 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 134676005841 DNA binding site [nucleotide binding] 134676005842 domain linker motif; other site 134676005843 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 134676005844 ligand binding site [chemical binding]; other site 134676005845 dimerization interface [polypeptide binding]; other site 134676005846 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 134676005847 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 134676005848 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 134676005849 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 134676005850 AsnC family; Region: AsnC_trans_reg; pfam01037 134676005851 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 134676005852 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 134676005853 putative substrate translocation pore; other site 134676005854 short chain dehydrogenase; Validated; Region: PRK08324 134676005855 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 134676005856 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 134676005857 NAD(P) binding site [chemical binding]; other site 134676005858 active site 134676005859 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 134676005860 N- and C-terminal domain interface [polypeptide binding]; other site 134676005861 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 134676005862 active site 134676005863 putative catalytic site [active] 134676005864 metal binding site [ion binding]; metal-binding site 134676005865 ATP binding site [chemical binding]; other site 134676005866 carbohydrate binding site [chemical binding]; other site 134676005867 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 134676005868 Cysteine-rich domain; Region: CCG; pfam02754 134676005869 Cysteine-rich domain; Region: CCG; pfam02754 134676005870 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 134676005871 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 134676005872 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 134676005873 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 134676005874 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 134676005875 dimerization interface [polypeptide binding]; other site 134676005876 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 134676005877 dimer interface [polypeptide binding]; other site 134676005878 phosphorylation site [posttranslational modification] 134676005879 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676005880 ATP binding site [chemical binding]; other site 134676005881 Mg2+ binding site [ion binding]; other site 134676005882 G-X-G motif; other site 134676005883 Response regulator receiver domain; Region: Response_reg; pfam00072 134676005884 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676005885 active site 134676005886 phosphorylation site [posttranslational modification] 134676005887 intermolecular recognition site; other site 134676005888 dimerization interface [polypeptide binding]; other site 134676005889 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 134676005890 putative binding surface; other site 134676005891 active site 134676005892 Response regulator receiver domain; Region: Response_reg; pfam00072 134676005893 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676005894 active site 134676005895 phosphorylation site [posttranslational modification] 134676005896 intermolecular recognition site; other site 134676005897 dimerization interface [polypeptide binding]; other site 134676005898 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 134676005899 dimer interface [polypeptide binding]; other site 134676005900 phosphorylation site [posttranslational modification] 134676005901 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 134676005902 HlyD family secretion protein; Region: HlyD_3; pfam13437 134676005903 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 134676005904 HlyD family secretion protein; Region: HlyD_3; pfam13437 134676005905 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 134676005906 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 134676005907 Walker A/P-loop; other site 134676005908 ATP binding site [chemical binding]; other site 134676005909 Q-loop/lid; other site 134676005910 ABC transporter signature motif; other site 134676005911 Walker B; other site 134676005912 D-loop; other site 134676005913 H-loop/switch region; other site 134676005914 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 134676005915 FtsX-like permease family; Region: FtsX; pfam02687 134676005916 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 134676005917 hypothetical protein; Provisional; Region: PRK07338 134676005918 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 134676005919 metal binding site [ion binding]; metal-binding site 134676005920 Uncharacterized conserved protein [Function unknown]; Region: COG3375 134676005921 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 134676005922 putative active site [active] 134676005923 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 134676005924 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 134676005925 active site 134676005926 octamer interface [polypeptide binding]; other site 134676005927 NB-ARC domain; Region: NB-ARC; pfam00931 134676005928 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 134676005929 structural tetrad; other site 134676005930 PQQ-like domain; Region: PQQ_2; pfam13360 134676005931 FOG: WD40 repeat [General function prediction only]; Region: COG2319 134676005932 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 134676005933 structural tetrad; other site 134676005934 aminotransferase; Validated; Region: PRK07046 134676005935 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 134676005936 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 134676005937 catalytic residue [active] 134676005938 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 134676005939 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 134676005940 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 134676005941 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 134676005942 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 134676005943 Uncharacterized conserved protein [Function unknown]; Region: COG3743 134676005944 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 134676005945 active site 134676005946 putative catalytic site [active] 134676005947 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 134676005948 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 134676005949 ABC-2 type transporter; Region: ABC2_membrane; cl17235 134676005950 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 134676005951 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 134676005952 Walker A/P-loop; other site 134676005953 ATP binding site [chemical binding]; other site 134676005954 Q-loop/lid; other site 134676005955 ABC transporter signature motif; other site 134676005956 Walker B; other site 134676005957 D-loop; other site 134676005958 H-loop/switch region; other site 134676005959 Predicted transcriptional regulators [Transcription]; Region: COG1695 134676005960 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 134676005961 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 134676005962 TAP-like protein; Region: Abhydrolase_4; pfam08386 134676005963 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 134676005964 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 134676005965 Walker A/P-loop; other site 134676005966 ATP binding site [chemical binding]; other site 134676005967 Q-loop/lid; other site 134676005968 ABC transporter signature motif; other site 134676005969 Walker B; other site 134676005970 D-loop; other site 134676005971 H-loop/switch region; other site 134676005972 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 134676005973 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 134676005974 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 134676005975 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 134676005976 NMT1/THI5 like; Region: NMT1; pfam09084 134676005977 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 134676005978 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 134676005979 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 134676005980 Bacterial transcriptional regulator; Region: IclR; pfam01614 134676005981 Domain of unknown function (DUF4173); Region: DUF4173; pfam13777 134676005982 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 134676005983 B12-binding domain/radical SAM domain protein, MJ_1487 family; Region: B12_SAM_MJ_1487; TIGR04013 134676005984 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 134676005985 B12 binding site [chemical binding]; other site 134676005986 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 134676005987 FeS/SAM binding site; other site 134676005988 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676005989 metal binding site [ion binding]; metal-binding site 134676005990 active site 134676005991 I-site; other site 134676005992 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 134676005993 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 134676005994 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 134676005995 active site 134676005996 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 134676005997 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 134676005998 Transcriptional regulator [Transcription]; Region: IclR; COG1414 134676005999 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 134676006000 Bacterial transcriptional regulator; Region: IclR; pfam01614 134676006001 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 134676006002 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 134676006003 active site 134676006004 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 134676006005 active site 134676006006 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 134676006007 tetramer interface [polypeptide binding]; other site 134676006008 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 134676006009 4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425 134676006010 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 134676006011 Phosphoesterase family; Region: Phosphoesterase; pfam04185 134676006012 Domain of unknown function (DUF756); Region: DUF756; pfam05506 134676006013 Domain of unknown function (DUF756); Region: DUF756; pfam05506 134676006014 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 134676006015 Hemerythrin-like domain; Region: Hr-like; cd12108 134676006016 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 134676006017 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 134676006018 dimerization interface [polypeptide binding]; other site 134676006019 DNA binding residues [nucleotide binding] 134676006020 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 134676006021 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 134676006022 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 134676006023 PAS domain; Region: PAS_9; pfam13426 134676006024 putative active site [active] 134676006025 heme pocket [chemical binding]; other site 134676006026 PAS domain S-box; Region: sensory_box; TIGR00229 134676006027 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 134676006028 putative active site [active] 134676006029 heme pocket [chemical binding]; other site 134676006030 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 134676006031 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 134676006032 putative active site [active] 134676006033 heme pocket [chemical binding]; other site 134676006034 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676006035 ATP binding site [chemical binding]; other site 134676006036 Mg2+ binding site [ion binding]; other site 134676006037 G-X-G motif; other site 134676006038 Response regulator receiver domain; Region: Response_reg; pfam00072 134676006039 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676006040 active site 134676006041 phosphorylation site [posttranslational modification] 134676006042 intermolecular recognition site; other site 134676006043 dimerization interface [polypeptide binding]; other site 134676006044 Excalibur calcium-binding domain; Region: Excalibur; cl05460 134676006045 malate dehydrogenase; Provisional; Region: PRK05442 134676006046 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 134676006047 NAD(P) binding site [chemical binding]; other site 134676006048 dimer interface [polypeptide binding]; other site 134676006049 malate binding site [chemical binding]; other site 134676006050 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 134676006051 SpoOM protein; Region: Spo0M; pfam07070 134676006052 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 134676006053 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 134676006054 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 134676006055 membrane-bound complex binding site; other site 134676006056 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 134676006057 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 134676006058 Walker A/P-loop; other site 134676006059 ATP binding site [chemical binding]; other site 134676006060 Q-loop/lid; other site 134676006061 ABC transporter signature motif; other site 134676006062 Walker B; other site 134676006063 D-loop; other site 134676006064 H-loop/switch region; other site 134676006065 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 134676006066 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 134676006067 dimer interface [polypeptide binding]; other site 134676006068 conserved gate region; other site 134676006069 putative PBP binding loops; other site 134676006070 ABC-ATPase subunit interface; other site 134676006071 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 134676006072 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 134676006073 active site 134676006074 iron coordination sites [ion binding]; other site 134676006075 substrate binding pocket [chemical binding]; other site 134676006076 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 134676006077 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 134676006078 active site 134676006079 non-prolyl cis peptide bond; other site 134676006080 FOG: CBS domain [General function prediction only]; Region: COG0517 134676006081 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 134676006082 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 134676006083 FeS/SAM binding site; other site 134676006084 coproporphyrinogen III oxidase; Validated; Region: PRK08208 134676006085 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 134676006086 FeS/SAM binding site; other site 134676006087 HemN C-terminal domain; Region: HemN_C; pfam06969 134676006088 Sulfatase; Region: Sulfatase; cl17466 134676006089 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 134676006090 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 134676006091 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 134676006092 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 134676006093 Coenzyme A binding pocket [chemical binding]; other site 134676006094 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 134676006095 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 134676006096 FAD binding pocket [chemical binding]; other site 134676006097 FAD binding motif [chemical binding]; other site 134676006098 phosphate binding motif [ion binding]; other site 134676006099 NAD binding pocket [chemical binding]; other site 134676006100 Response regulator receiver domain; Region: Response_reg; pfam00072 134676006101 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676006102 active site 134676006103 phosphorylation site [posttranslational modification] 134676006104 intermolecular recognition site; other site 134676006105 dimerization interface [polypeptide binding]; other site 134676006106 PAS fold; Region: PAS_3; pfam08447 134676006107 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 134676006108 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 134676006109 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 134676006110 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 134676006111 anti sigma factor interaction site; other site 134676006112 regulatory phosphorylation site [posttranslational modification]; other site 134676006113 glutamine synthetase; Region: PLN02284 134676006114 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 134676006115 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 134676006116 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 134676006117 Ligand Binding Site [chemical binding]; other site 134676006118 Universal stress protein family; Region: Usp; pfam00582 134676006119 Ligand Binding Site [chemical binding]; other site 134676006120 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 134676006121 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 134676006122 Walker A motif; other site 134676006123 ATP binding site [chemical binding]; other site 134676006124 Walker B motif; other site 134676006125 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 134676006126 non-specific DNA binding site [nucleotide binding]; other site 134676006127 salt bridge; other site 134676006128 sequence-specific DNA binding site [nucleotide binding]; other site 134676006129 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 134676006130 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 134676006131 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 134676006132 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 134676006133 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 134676006134 active site 134676006135 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 134676006136 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 134676006137 motif II; other site 134676006138 Methyltransferase domain; Region: Methyltransf_11; pfam08241 134676006139 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 134676006140 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 134676006141 substrate binding site [chemical binding]; other site 134676006142 ATP binding site [chemical binding]; other site 134676006143 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676006144 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 134676006145 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 134676006146 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 134676006147 active site 134676006148 2-hydroxycyclohexanecarboxyl-CoA dehydrogenase; Region: benzo_BadH; TIGR03206 134676006149 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 134676006150 NAD(P) binding site [chemical binding]; other site 134676006151 active site 134676006152 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 134676006153 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 134676006154 active site 134676006155 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 134676006156 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 134676006157 Major Facilitator Superfamily; Region: MFS_1; pfam07690 134676006158 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 134676006159 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 134676006160 DNA binding residues [nucleotide binding] 134676006161 dimer interface [polypeptide binding]; other site 134676006162 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 134676006163 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 134676006164 NodB motif; other site 134676006165 active site 134676006166 catalytic site [active] 134676006167 metal binding site [ion binding]; metal-binding site 134676006168 glycogen branching enzyme; Provisional; Region: PRK14705 134676006169 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 134676006170 active site 134676006171 catalytic residues [active] 134676006172 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 134676006173 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 134676006174 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 134676006175 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 134676006176 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 134676006177 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 134676006178 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 134676006179 Transcriptional regulators [Transcription]; Region: PurR; COG1609 134676006180 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 134676006181 DNA binding site [nucleotide binding] 134676006182 domain linker motif; other site 134676006183 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 134676006184 dimerization interface [polypeptide binding]; other site 134676006185 ligand binding site [chemical binding]; other site 134676006186 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 134676006187 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 134676006188 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 134676006189 dimer interface [polypeptide binding]; other site 134676006190 conserved gate region; other site 134676006191 putative PBP binding loops; other site 134676006192 ABC-ATPase subunit interface; other site 134676006193 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 134676006194 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 134676006195 dimer interface [polypeptide binding]; other site 134676006196 conserved gate region; other site 134676006197 putative PBP binding loops; other site 134676006198 ABC-ATPase subunit interface; other site 134676006199 putative alpha-glucosidase; Provisional; Region: PRK10658 134676006200 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 134676006201 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 134676006202 active site 134676006203 homotrimer interface [polypeptide binding]; other site 134676006204 catalytic site [active] 134676006205 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 134676006206 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 134676006207 putative Zn2+ binding site [ion binding]; other site 134676006208 putative DNA binding site [nucleotide binding]; other site 134676006209 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 134676006210 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 134676006211 substrate binding site [chemical binding]; other site 134676006212 oxyanion hole (OAH) forming residues; other site 134676006213 trimer interface [polypeptide binding]; other site 134676006214 putative phosphoketolase; Provisional; Region: PRK05261 134676006215 XFP N-terminal domain; Region: XFP_N; pfam09364 134676006216 XFP C-terminal domain; Region: XFP_C; pfam09363 134676006217 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 134676006218 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 134676006219 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 134676006220 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 134676006221 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 134676006222 Walker A/P-loop; other site 134676006223 ATP binding site [chemical binding]; other site 134676006224 Q-loop/lid; other site 134676006225 ABC transporter signature motif; other site 134676006226 Walker B; other site 134676006227 D-loop; other site 134676006228 H-loop/switch region; other site 134676006229 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 134676006230 PDGLE domain; Region: PDGLE; pfam13190 134676006231 ABC-type Co2+ transport system, permease component [Inorganic ion transport and metabolism]; Region: CbiM; cl00397 134676006232 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 134676006233 Response regulator receiver domain; Region: Response_reg; pfam00072 134676006234 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676006235 active site 134676006236 phosphorylation site [posttranslational modification] 134676006237 intermolecular recognition site; other site 134676006238 dimerization interface [polypeptide binding]; other site 134676006239 PAS fold; Region: PAS; pfam00989 134676006240 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 134676006241 putative active site [active] 134676006242 heme pocket [chemical binding]; other site 134676006243 GAF domain; Region: GAF; cl17456 134676006244 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 134676006245 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 134676006246 dimer interface [polypeptide binding]; other site 134676006247 phosphorylation site [posttranslational modification] 134676006248 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676006249 ATP binding site [chemical binding]; other site 134676006250 Mg2+ binding site [ion binding]; other site 134676006251 G-X-G motif; other site 134676006252 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 134676006253 Mg2+ binding site [ion binding]; other site 134676006254 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 134676006255 anti sigma factor interaction site; other site 134676006256 regulatory phosphorylation site [posttranslational modification]; other site 134676006257 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 134676006258 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 134676006259 dimerization interface [polypeptide binding]; other site 134676006260 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 134676006261 dimer interface [polypeptide binding]; other site 134676006262 putative CheW interface [polypeptide binding]; other site 134676006263 GAF domain; Region: GAF; pfam01590 134676006264 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 134676006265 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 134676006266 dimer interface [polypeptide binding]; other site 134676006267 phosphorylation site [posttranslational modification] 134676006268 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676006269 ATP binding site [chemical binding]; other site 134676006270 Mg2+ binding site [ion binding]; other site 134676006271 G-X-G motif; other site 134676006272 Response regulator receiver domain; Region: Response_reg; pfam00072 134676006273 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676006274 active site 134676006275 phosphorylation site [posttranslational modification] 134676006276 intermolecular recognition site; other site 134676006277 dimerization interface [polypeptide binding]; other site 134676006278 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 134676006279 L-rhamnose catabolism isomerase, Pseudomonas stutzeri subtype; Region: L_rham_iso_rhiz; TIGR02629 134676006280 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 134676006281 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 134676006282 TM-ABC transporter signature motif; other site 134676006283 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 134676006284 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 134676006285 TM-ABC transporter signature motif; other site 134676006286 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 134676006287 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 134676006288 Walker A/P-loop; other site 134676006289 ATP binding site [chemical binding]; other site 134676006290 Q-loop/lid; other site 134676006291 ABC transporter signature motif; other site 134676006292 Walker B; other site 134676006293 D-loop; other site 134676006294 H-loop/switch region; other site 134676006295 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 134676006296 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 134676006297 rhamnose ABC transporter, rhamnose-binding protein; Region: RhaS; TIGR02637 134676006298 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 134676006299 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 134676006300 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 134676006301 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 134676006302 active site 134676006303 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 134676006304 Catalytic domain of Protein Kinases; Region: PKc; cd00180 134676006305 active site 134676006306 ATP binding site [chemical binding]; other site 134676006307 substrate binding site [chemical binding]; other site 134676006308 activation loop (A-loop); other site 134676006309 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 134676006310 putative active site [active] 134676006311 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 134676006312 DNA-binding site [nucleotide binding]; DNA binding site 134676006313 transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481 134676006314 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 134676006315 pyridoxal 5'-phosphate binding site [chemical binding]; other site 134676006316 homodimer interface [polypeptide binding]; other site 134676006317 catalytic residue [active] 134676006318 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 134676006319 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 134676006320 tetrameric interface [polypeptide binding]; other site 134676006321 NAD binding site [chemical binding]; other site 134676006322 catalytic residues [active] 134676006323 hypothetical protein; Provisional; Region: PRK06062 134676006324 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 134676006325 inhibitor-cofactor binding pocket; inhibition site 134676006326 pyridoxal 5'-phosphate binding site [chemical binding]; other site 134676006327 catalytic residue [active] 134676006328 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 134676006329 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 134676006330 tetrameric interface [polypeptide binding]; other site 134676006331 NAD binding site [chemical binding]; other site 134676006332 catalytic residues [active] 134676006333 substrate binding site [chemical binding]; other site 134676006334 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 134676006335 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 134676006336 Walker A/P-loop; other site 134676006337 ATP binding site [chemical binding]; other site 134676006338 Q-loop/lid; other site 134676006339 ABC transporter signature motif; other site 134676006340 Walker B; other site 134676006341 D-loop; other site 134676006342 H-loop/switch region; other site 134676006343 TOBE domain; Region: TOBE_2; pfam08402 134676006344 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 134676006345 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 134676006346 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 134676006347 dimer interface [polypeptide binding]; other site 134676006348 conserved gate region; other site 134676006349 putative PBP binding loops; other site 134676006350 ABC-ATPase subunit interface; other site 134676006351 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 134676006352 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 134676006353 dimer interface [polypeptide binding]; other site 134676006354 conserved gate region; other site 134676006355 putative PBP binding loops; other site 134676006356 ABC-ATPase subunit interface; other site 134676006357 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 134676006358 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 134676006359 hypothetical protein; Provisional; Region: PRK06541 134676006360 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 134676006361 inhibitor-cofactor binding pocket; inhibition site 134676006362 pyridoxal 5'-phosphate binding site [chemical binding]; other site 134676006363 catalytic residue [active] 134676006364 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 134676006365 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 134676006366 DNA binding residues [nucleotide binding] 134676006367 putative dimer interface [polypeptide binding]; other site 134676006368 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 134676006369 Response regulator receiver domain; Region: Response_reg; pfam00072 134676006370 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676006371 active site 134676006372 phosphorylation site [posttranslational modification] 134676006373 intermolecular recognition site; other site 134676006374 dimerization interface [polypeptide binding]; other site 134676006375 PAS domain; Region: PAS; smart00091 134676006376 PAS fold; Region: PAS_4; pfam08448 134676006377 GAF domain; Region: GAF; pfam01590 134676006378 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 134676006379 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 134676006380 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 134676006381 dimer interface [polypeptide binding]; other site 134676006382 phosphorylation site [posttranslational modification] 134676006383 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676006384 ATP binding site [chemical binding]; other site 134676006385 Mg2+ binding site [ion binding]; other site 134676006386 G-X-G motif; other site 134676006387 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 134676006388 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 134676006389 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 134676006390 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 134676006391 putative DNA binding site [nucleotide binding]; other site 134676006392 putative Zn2+ binding site [ion binding]; other site 134676006393 AsnC family; Region: AsnC_trans_reg; pfam01037 134676006394 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 134676006395 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 134676006396 inhibitor-cofactor binding pocket; inhibition site 134676006397 pyridoxal 5'-phosphate binding site [chemical binding]; other site 134676006398 catalytic residue [active] 134676006399 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 134676006400 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 134676006401 tetrameric interface [polypeptide binding]; other site 134676006402 NAD binding site [chemical binding]; other site 134676006403 catalytic residues [active] 134676006404 substrate binding site [chemical binding]; other site 134676006405 GAF domain; Region: GAF; pfam01590 134676006406 GAF domain; Region: GAF_2; pfam13185 134676006407 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 134676006408 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 134676006409 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 134676006410 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 134676006411 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 134676006412 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 134676006413 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 134676006414 dimer interface [polypeptide binding]; other site 134676006415 conserved gate region; other site 134676006416 putative PBP binding loops; other site 134676006417 ABC-ATPase subunit interface; other site 134676006418 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 134676006419 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 134676006420 dimer interface [polypeptide binding]; other site 134676006421 conserved gate region; other site 134676006422 putative PBP binding loops; other site 134676006423 ABC-ATPase subunit interface; other site 134676006424 Transcriptional regulators [Transcription]; Region: PurR; COG1609 134676006425 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 134676006426 DNA binding site [nucleotide binding] 134676006427 domain linker motif; other site 134676006428 Ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation; Region: PBP1_CatR_like; cd06296 134676006429 putative dimerization interface [polypeptide binding]; other site 134676006430 putative ligand binding site [chemical binding]; other site 134676006431 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 134676006432 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 134676006433 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 134676006434 Uncharacterized conserved protein [Function unknown]; Region: COG1262 134676006435 HAMP domain; Region: HAMP; pfam00672 134676006436 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 134676006437 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 134676006438 dimer interface [polypeptide binding]; other site 134676006439 putative CheW interface [polypeptide binding]; other site 134676006440 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 134676006441 putative active site pocket [active] 134676006442 cleavage site 134676006443 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 134676006444 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 134676006445 Domain of unknown function (DUF427); Region: DUF427; cl00998 134676006446 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 134676006447 putative deacylase active site [active] 134676006448 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 134676006449 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 134676006450 NADP binding site [chemical binding]; other site 134676006451 Predicted transcriptional regulators [Transcription]; Region: COG1733 134676006452 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 134676006453 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 134676006454 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 134676006455 dimerization interface [polypeptide binding]; other site 134676006456 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 134676006457 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 134676006458 dimer interface [polypeptide binding]; other site 134676006459 putative CheW interface [polypeptide binding]; other site 134676006460 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 134676006461 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676006462 metal binding site [ion binding]; metal-binding site 134676006463 active site 134676006464 I-site; other site 134676006465 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 134676006466 CoA-transferase family III; Region: CoA_transf_3; pfam02515 134676006467 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 134676006468 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 134676006469 substrate binding site [chemical binding]; other site 134676006470 oxyanion hole (OAH) forming residues; other site 134676006471 trimer interface [polypeptide binding]; other site 134676006472 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 134676006473 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 134676006474 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 134676006475 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 134676006476 dimer interface [polypeptide binding]; other site 134676006477 active site 134676006478 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 134676006479 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 134676006480 active site 134676006481 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 134676006482 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676006483 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 134676006484 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 134676006485 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 134676006486 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 134676006487 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 134676006488 Walker A/P-loop; other site 134676006489 ATP binding site [chemical binding]; other site 134676006490 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 134676006491 putative active site [active] 134676006492 putative metal-binding site [ion binding]; other site 134676006493 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 134676006494 Part of AAA domain; Region: AAA_19; pfam13245 134676006495 Family description; Region: UvrD_C_2; pfam13538 134676006496 CHAT domain; Region: CHAT; pfam12770 134676006497 Domain of unknown function (DUF4263); Region: DUF4263; pfam14082 134676006498 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 134676006499 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 134676006500 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676006501 active site 134676006502 phosphorylation site [posttranslational modification] 134676006503 intermolecular recognition site; other site 134676006504 dimerization interface [polypeptide binding]; other site 134676006505 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 134676006506 DNA binding residues [nucleotide binding] 134676006507 dimerization interface [polypeptide binding]; other site 134676006508 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 134676006509 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676006510 ATP binding site [chemical binding]; other site 134676006511 Mg2+ binding site [ion binding]; other site 134676006512 G-X-G motif; other site 134676006513 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 134676006514 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 134676006515 acyl-activating enzyme (AAE) consensus motif; other site 134676006516 AMP binding site [chemical binding]; other site 134676006517 active site 134676006518 CoA binding site [chemical binding]; other site 134676006519 Sulfatase; Region: Sulfatase; cl17466 134676006520 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 134676006521 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 134676006522 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 134676006523 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 134676006524 dimer interface [polypeptide binding]; other site 134676006525 conserved gate region; other site 134676006526 putative PBP binding loops; other site 134676006527 ABC-ATPase subunit interface; other site 134676006528 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 134676006529 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 134676006530 putative PBP binding loops; other site 134676006531 dimer interface [polypeptide binding]; other site 134676006532 ABC-ATPase subunit interface; other site 134676006533 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 134676006534 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 134676006535 Walker A/P-loop; other site 134676006536 ATP binding site [chemical binding]; other site 134676006537 Q-loop/lid; other site 134676006538 ABC transporter signature motif; other site 134676006539 Walker B; other site 134676006540 D-loop; other site 134676006541 H-loop/switch region; other site 134676006542 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 134676006543 Walker A/P-loop; other site 134676006544 ATP binding site [chemical binding]; other site 134676006545 Q-loop/lid; other site 134676006546 ABC transporter signature motif; other site 134676006547 Walker B; other site 134676006548 D-loop; other site 134676006549 H-loop/switch region; other site 134676006550 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 134676006551 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 134676006552 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 134676006553 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 134676006554 active site 134676006555 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 134676006556 non-prolyl cis peptide bond; other site 134676006557 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 134676006558 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 134676006559 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 134676006560 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 134676006561 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 134676006562 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 134676006563 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 134676006564 putative NAD(P) binding site [chemical binding]; other site 134676006565 Predicted transcriptional regulators [Transcription]; Region: COG1733 134676006566 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 134676006567 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 134676006568 Predicted transcriptional regulators [Transcription]; Region: COG1695 134676006569 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 134676006570 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 134676006571 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 134676006572 active site 134676006573 catalytic tetrad [active] 134676006574 Transcriptional regulator [Transcription]; Region: LysR; COG0583 134676006575 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 134676006576 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 134676006577 dimerization interface [polypeptide binding]; other site 134676006578 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 134676006579 sequence-specific DNA binding site [nucleotide binding]; other site 134676006580 salt bridge; other site 134676006581 Domain of unknown function (DUF397); Region: DUF397; pfam04149 134676006582 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 134676006583 salt bridge; other site 134676006584 non-specific DNA binding site [nucleotide binding]; other site 134676006585 sequence-specific DNA binding site [nucleotide binding]; other site 134676006586 Tetratricopeptide repeat; Region: TPR_12; pfam13424 134676006587 Tetratricopeptide repeat; Region: TPR_12; pfam13424 134676006588 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 134676006589 Coenzyme A binding pocket [chemical binding]; other site 134676006590 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 134676006591 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 134676006592 substrate binding pocket [chemical binding]; other site 134676006593 membrane-bound complex binding site; other site 134676006594 hinge residues; other site 134676006595 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 134676006596 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 134676006597 Walker A/P-loop; other site 134676006598 ATP binding site [chemical binding]; other site 134676006599 Q-loop/lid; other site 134676006600 ABC transporter signature motif; other site 134676006601 Walker B; other site 134676006602 D-loop; other site 134676006603 H-loop/switch region; other site 134676006604 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 134676006605 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 134676006606 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 134676006607 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 134676006608 dimer interface [polypeptide binding]; other site 134676006609 conserved gate region; other site 134676006610 putative PBP binding loops; other site 134676006611 ABC-ATPase subunit interface; other site 134676006612 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 134676006613 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 134676006614 dimer interface [polypeptide binding]; other site 134676006615 conserved gate region; other site 134676006616 putative PBP binding loops; other site 134676006617 ABC-ATPase subunit interface; other site 134676006618 taurine ABC transporter, periplasmic binding protein; Region: taurine_ABC_bnd; TIGR01729 134676006619 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 134676006620 substrate binding pocket [chemical binding]; other site 134676006621 membrane-bound complex binding site; other site 134676006622 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 134676006623 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 134676006624 Walker A/P-loop; other site 134676006625 ATP binding site [chemical binding]; other site 134676006626 Q-loop/lid; other site 134676006627 ABC transporter signature motif; other site 134676006628 Walker B; other site 134676006629 D-loop; other site 134676006630 H-loop/switch region; other site 134676006631 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676006632 metal binding site [ion binding]; metal-binding site 134676006633 active site 134676006634 I-site; other site 134676006635 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 134676006636 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 134676006637 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 134676006638 active site 134676006639 catalytic site [active] 134676006640 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 134676006641 Transcriptional regulators [Transcription]; Region: PurR; COG1609 134676006642 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 134676006643 DNA binding site [nucleotide binding] 134676006644 domain linker motif; other site 134676006645 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 134676006646 putative dimerization interface [polypeptide binding]; other site 134676006647 putative ligand binding site [chemical binding]; other site 134676006648 CsbD-like; Region: CsbD; pfam05532 134676006649 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 134676006650 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 134676006651 active site 134676006652 dimer interface [polypeptide binding]; other site 134676006653 non-prolyl cis peptide bond; other site 134676006654 insertion regions; other site 134676006655 MMPL family; Region: MMPL; pfam03176 134676006656 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 134676006657 Tetratricopeptide repeat; Region: TPR_16; pfam13432 134676006658 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 134676006659 binding surface 134676006660 TPR motif; other site 134676006661 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 134676006662 TPR repeat; Region: TPR_11; pfam13414 134676006663 binding surface 134676006664 TPR motif; other site 134676006665 Transcriptional regulators [Transcription]; Region: MarR; COG1846 134676006666 MarR family; Region: MarR_2; cl17246 134676006667 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 134676006668 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 134676006669 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 134676006670 Walker A/P-loop; other site 134676006671 ATP binding site [chemical binding]; other site 134676006672 Q-loop/lid; other site 134676006673 ABC transporter signature motif; other site 134676006674 Walker B; other site 134676006675 D-loop; other site 134676006676 H-loop/switch region; other site 134676006677 Methyltransferase domain; Region: Methyltransf_31; pfam13847 134676006678 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 134676006679 S-adenosylmethionine binding site [chemical binding]; other site 134676006680 citrate synthase 2; Provisional; Region: PRK12350 134676006681 Citrate synthase; Region: Citrate_synt; pfam00285 134676006682 oxalacetate binding site [chemical binding]; other site 134676006683 citrylCoA binding site [chemical binding]; other site 134676006684 coenzyme A binding site [chemical binding]; other site 134676006685 catalytic triad [active] 134676006686 Helix-turn-helix domain; Region: HTH_17; pfam12728 134676006687 Citrate synthase; Region: Citrate_synt; pfam00285 134676006688 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 134676006689 oxalacetate binding site [chemical binding]; other site 134676006690 citrylCoA binding site [chemical binding]; other site 134676006691 coenzyme A binding site [chemical binding]; other site 134676006692 catalytic triad [active] 134676006693 FMN binding site [chemical binding]; other site 134676006694 Nitroreductase family; Region: Nitroreductase; pfam00881 134676006695 dimer interface [polypeptide binding]; other site 134676006696 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 134676006697 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 134676006698 short chain dehydrogenase; Provisional; Region: PRK06181 134676006699 NAD(P) binding site [chemical binding]; other site 134676006700 active site 134676006701 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 134676006702 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 134676006703 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 134676006704 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676006705 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 134676006706 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 134676006707 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 134676006708 active site 134676006709 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 134676006710 DNA binding site [nucleotide binding] 134676006711 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 134676006712 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 134676006713 putative active site [active] 134676006714 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 134676006715 active site 134676006716 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 134676006717 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 134676006718 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 134676006719 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 134676006720 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 134676006721 iron-sulfur cluster [ion binding]; other site 134676006722 [2Fe-2S] cluster binding site [ion binding]; other site 134676006723 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 134676006724 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 134676006725 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 134676006726 Walker A/P-loop; other site 134676006727 ATP binding site [chemical binding]; other site 134676006728 Q-loop/lid; other site 134676006729 ABC transporter signature motif; other site 134676006730 Walker B; other site 134676006731 D-loop; other site 134676006732 H-loop/switch region; other site 134676006733 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 134676006734 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 134676006735 Walker A/P-loop; other site 134676006736 ATP binding site [chemical binding]; other site 134676006737 Q-loop/lid; other site 134676006738 ABC transporter signature motif; other site 134676006739 Walker B; other site 134676006740 D-loop; other site 134676006741 H-loop/switch region; other site 134676006742 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 134676006743 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 134676006744 dimer interface [polypeptide binding]; other site 134676006745 conserved gate region; other site 134676006746 putative PBP binding loops; other site 134676006747 ABC-ATPase subunit interface; other site 134676006748 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 134676006749 dimer interface [polypeptide binding]; other site 134676006750 conserved gate region; other site 134676006751 putative PBP binding loops; other site 134676006752 ABC-ATPase subunit interface; other site 134676006753 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 134676006754 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 134676006755 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 134676006756 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 134676006757 Cellulose binding domain; Region: CBM_2; pfam00553 134676006758 Cellulose binding domain; Region: CBM_2; pfam00553 134676006759 Glycosyl hydrolase family 48; Region: Glyco_hydro_48; pfam02011 134676006760 Chitin binding domain; Region: Chitin_bind_3; pfam03067 134676006761 Cellulose binding domain; Region: CBM_2; pfam00553 134676006762 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 134676006763 active site 134676006764 catalytic triad [active] 134676006765 oxyanion hole [active] 134676006766 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 134676006767 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 134676006768 nudix motif; other site 134676006769 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 134676006770 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 134676006771 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 134676006772 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 134676006773 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 134676006774 TM2 domain; Region: TM2; pfam05154 134676006775 Transcriptional regulator [Transcription]; Region: LysR; COG0583 134676006776 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 134676006777 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 134676006778 dimerization interface [polypeptide binding]; other site 134676006779 EamA-like transporter family; Region: EamA; pfam00892 134676006780 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 134676006781 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 134676006782 Domain of unknown function (DUF385); Region: DUF385; pfam04075 134676006783 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 134676006784 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 134676006785 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 134676006786 Cytochrome P450; Region: p450; cl12078 134676006787 Uncharacterized conserved protein [Function unknown]; Region: COG3287 134676006788 FIST N domain; Region: FIST; pfam08495 134676006789 FIST C domain; Region: FIST_C; pfam10442 134676006790 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676006791 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 134676006792 metal binding site [ion binding]; metal-binding site 134676006793 active site 134676006794 I-site; other site 134676006795 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 134676006796 sequence-specific DNA binding site [nucleotide binding]; other site 134676006797 salt bridge; other site 134676006798 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 134676006799 active site 134676006800 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 134676006801 S-adenosylmethionine binding site [chemical binding]; other site 134676006802 Prokaryotic phospholipase A2; Region: Phospholip_A2_3; pfam09056 134676006803 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 134676006804 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 134676006805 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 134676006806 sugar binding site [chemical binding]; other site 134676006807 Putative esterase; Region: Esterase; pfam00756 134676006808 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 134676006809 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 134676006810 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 134676006811 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 134676006812 SPFH domain / Band 7 family; Region: Band_7; pfam01145 134676006813 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 134676006814 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 134676006815 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 134676006816 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 134676006817 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 134676006818 hypothetical protein; Provisional; Region: PRK02237 134676006819 Prokaryotic phospholipase A2; Region: Phospholip_A2_3; pfam09056 134676006820 cyclase homology domain; Region: CHD; cd07302 134676006821 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 134676006822 nucleotidyl binding site; other site 134676006823 metal binding site [ion binding]; metal-binding site 134676006824 dimer interface [polypeptide binding]; other site 134676006825 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 134676006826 cyclase homology domain; Region: CHD; cd07302 134676006827 dimer interface [polypeptide binding]; other site 134676006828 nucleotidyl binding site; other site 134676006829 metal binding site [ion binding]; metal-binding site 134676006830 Predicted ATPase [General function prediction only]; Region: COG3899 134676006831 AAA ATPase domain; Region: AAA_16; pfam13191 134676006832 Tetratricopeptide repeat; Region: TPR_12; pfam13424 134676006833 Tetratricopeptide repeat; Region: TPR_12; pfam13424 134676006834 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 134676006835 binding surface 134676006836 TPR motif; other site 134676006837 Tetratricopeptide repeat; Region: TPR_12; pfam13424 134676006838 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 134676006839 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676006840 WHG domain; Region: WHG; pfam13305 134676006841 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 134676006842 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 134676006843 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 134676006844 NADH(P)-binding; Region: NAD_binding_10; pfam13460 134676006845 NAD(P) binding site [chemical binding]; other site 134676006846 active site 134676006847 H+ Antiporter protein; Region: 2A0121; TIGR00900 134676006848 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 134676006849 putative substrate translocation pore; other site 134676006850 tetracycline repressor protein TetR; Provisional; Region: PRK13756 134676006851 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676006852 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 134676006853 Domain of unknown function DUF20; Region: UPF0118; pfam01594 134676006854 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 134676006855 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 134676006856 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 134676006857 active site 134676006858 Zn binding site [ion binding]; other site 134676006859 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 134676006860 catalytic core [active] 134676006861 TrkA-N domain; Region: TrkA_N; pfam02254 134676006862 Ion channel; Region: Ion_trans_2; pfam07885 134676006863 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 134676006864 TrkA-N domain; Region: TrkA_N; pfam02254 134676006865 TrkA-C domain; Region: TrkA_C; pfam02080 134676006866 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 134676006867 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 134676006868 putative active site [active] 134676006869 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 134676006870 classical (c) SDRs; Region: SDR_c; cd05233 134676006871 NAD(P) binding site [chemical binding]; other site 134676006872 active site 134676006873 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 134676006874 dimer interface [polypeptide binding]; other site 134676006875 active site 134676006876 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 134676006877 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 134676006878 substrate binding site [chemical binding]; other site 134676006879 ATP binding site [chemical binding]; other site 134676006880 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 134676006881 active site 134676006882 HIGH motif; other site 134676006883 nucleotide binding site [chemical binding]; other site 134676006884 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 134676006885 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 134676006886 putative ADP-binding pocket [chemical binding]; other site 134676006887 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 134676006888 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 134676006889 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 134676006890 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 134676006891 active site 134676006892 motif I; other site 134676006893 motif II; other site 134676006894 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 134676006895 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 134676006896 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 134676006897 putative active site [active] 134676006898 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 134676006899 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 134676006900 Probable Catalytic site; other site 134676006901 metal-binding site 134676006902 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 134676006903 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 134676006904 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 134676006905 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 134676006906 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 134676006907 NAD(P) binding site [chemical binding]; other site 134676006908 catalytic residues [active] 134676006909 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 134676006910 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 134676006911 active site 134676006912 H+ Antiporter protein; Region: 2A0121; TIGR00900 134676006913 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 134676006914 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 134676006915 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 134676006916 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 134676006917 anti sigma factor interaction site; other site 134676006918 regulatory phosphorylation site [posttranslational modification]; other site 134676006919 ChaB; Region: ChaB; pfam06150 134676006920 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 134676006921 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 134676006922 iron-sulfur cluster [ion binding]; other site 134676006923 [2Fe-2S] cluster binding site [ion binding]; other site 134676006924 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 134676006925 anti sigma factor interaction site; other site 134676006926 regulatory phosphorylation site [posttranslational modification]; other site 134676006927 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 134676006928 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 134676006929 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 134676006930 Hemerythrin-like domain; Region: Hr-like; cd12108 134676006931 Fe binding site [ion binding]; other site 134676006932 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 134676006933 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 134676006934 Winged helix-turn helix; Region: HTH_29; pfam13551 134676006935 Integrase core domain; Region: rve; pfam00665 134676006936 Integrase core domain; Region: rve_3; pfam13683 134676006937 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 134676006938 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 134676006939 hypothetical protein; Validated; Region: PRK00029 134676006940 Uncharacterized conserved protein [Function unknown]; Region: COG0397 134676006941 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 134676006942 Part of AAA domain; Region: AAA_19; pfam13245 134676006943 Family description; Region: UvrD_C_2; pfam13538 134676006944 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 134676006945 substrate binding site [chemical binding]; other site 134676006946 active site 134676006947 Uncharacterized conserved protein [Function unknown]; Region: COG2128 134676006948 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 134676006949 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 134676006950 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 134676006951 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 134676006952 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 134676006953 Amino acid permease; Region: AA_permease_2; pfam13520 134676006954 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cl15820 134676006955 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 134676006956 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676006957 metal binding site [ion binding]; metal-binding site 134676006958 active site 134676006959 I-site; other site 134676006960 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 134676006961 CHAT domain; Region: CHAT; cl17868 134676006962 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 134676006963 Walker A motif; other site 134676006964 ATP binding site [chemical binding]; other site 134676006965 MoxR-like ATPases [General function prediction only]; Region: COG0714 134676006966 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 134676006967 Walker B motif; other site 134676006968 arginine finger; other site 134676006969 Protein of unknown function DUF58; Region: DUF58; pfam01882 134676006970 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 134676006971 thiamine pyrophosphate protein; Provisional; Region: PRK08273 134676006972 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 134676006973 PYR/PP interface [polypeptide binding]; other site 134676006974 dimer interface [polypeptide binding]; other site 134676006975 tetramer interface [polypeptide binding]; other site 134676006976 TPP binding site [chemical binding]; other site 134676006977 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 134676006978 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 134676006979 TPP-binding site [chemical binding]; other site 134676006980 Transcriptional regulator [Transcription]; Region: LysR; COG0583 134676006981 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 134676006982 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 134676006983 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 134676006984 dimerization interface [polypeptide binding]; other site 134676006985 DPS ferroxidase diiron center [ion binding]; other site 134676006986 ion pore; other site 134676006987 short chain dehydrogenase; Provisional; Region: PRK06701 134676006988 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 134676006989 NAD binding site [chemical binding]; other site 134676006990 metal binding site [ion binding]; metal-binding site 134676006991 active site 134676006992 Amb_all domain; Region: Amb_all; smart00656 134676006993 Cation efflux family; Region: Cation_efflux; pfam01545 134676006994 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 134676006995 active site 134676006996 catalytic residues [active] 134676006997 metal binding site [ion binding]; metal-binding site 134676006998 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 134676006999 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 134676007000 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 134676007001 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 134676007002 D-pathway; other site 134676007003 Putative ubiquinol binding site [chemical binding]; other site 134676007004 Low-spin heme (heme b) binding site [chemical binding]; other site 134676007005 Putative water exit pathway; other site 134676007006 Binuclear center (heme o3/CuB) [ion binding]; other site 134676007007 K-pathway; other site 134676007008 Putative proton exit pathway; other site 134676007009 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 134676007010 putative active site [active] 134676007011 aspartate aminotransferase; Provisional; Region: PRK05764 134676007012 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 134676007013 pyridoxal 5'-phosphate binding site [chemical binding]; other site 134676007014 homodimer interface [polypeptide binding]; other site 134676007015 catalytic residue [active] 134676007016 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 134676007017 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 134676007018 Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028 134676007019 active site 134676007020 DNA binding site [nucleotide binding] 134676007021 Int/Topo IB signature motif; other site 134676007022 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 134676007023 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 134676007024 NAD binding site [chemical binding]; other site 134676007025 catalytic Zn binding site [ion binding]; other site 134676007026 structural Zn binding site [ion binding]; other site 134676007027 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 134676007028 Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; pfam10069 134676007029 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 134676007030 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 134676007031 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 134676007032 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 134676007033 DNA binding residues [nucleotide binding] 134676007034 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 134676007035 anti sigma factor interaction site; other site 134676007036 regulatory phosphorylation site [posttranslational modification]; other site 134676007037 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 134676007038 hypothetical protein; Reviewed; Region: PRK09588 134676007039 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 134676007040 Predicted permeases [General function prediction only]; Region: COG0701 134676007041 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 134676007042 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 134676007043 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 134676007044 PAS domain; Region: PAS_9; pfam13426 134676007045 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 134676007046 putative active site [active] 134676007047 heme pocket [chemical binding]; other site 134676007048 PAS fold; Region: PAS; pfam00989 134676007049 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 134676007050 putative active site [active] 134676007051 heme pocket [chemical binding]; other site 134676007052 CheB methylesterase; Region: CheB_methylest; pfam01339 134676007053 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 134676007054 anti sigma factor interaction site; other site 134676007055 regulatory phosphorylation site [posttranslational modification]; other site 134676007056 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 134676007057 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 134676007058 anti sigma factor interaction site; other site 134676007059 regulatory phosphorylation site [posttranslational modification]; other site 134676007060 CheB methylesterase; Region: CheB_methylest; pfam01339 134676007061 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 134676007062 FMN binding site [chemical binding]; other site 134676007063 dimer interface [polypeptide binding]; other site 134676007064 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 134676007065 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 134676007066 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 134676007067 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 134676007068 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 134676007069 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676007070 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 134676007071 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 134676007072 metabolite-proton symporter; Region: 2A0106; TIGR00883 134676007073 putative substrate translocation pore; other site 134676007074 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 134676007075 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 134676007076 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 134676007077 Transcriptional regulators [Transcription]; Region: GntR; COG1802 134676007078 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 134676007079 DNA-binding site [nucleotide binding]; DNA binding site 134676007080 Alpha-L-arabinofuranosidase B, catalytic; Region: ArabFuran-catal; pfam09206 134676007081 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 134676007082 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 134676007083 putative sugar binding sites [chemical binding]; other site 134676007084 Q-X-W motif; other site 134676007085 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 134676007086 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 134676007087 putative sugar binding sites [chemical binding]; other site 134676007088 Q-X-W motif; other site 134676007089 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 134676007090 active site 134676007091 catalytic triad [active] 134676007092 oxyanion hole [active] 134676007093 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 134676007094 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 134676007095 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 134676007096 conserved cys residue [active] 134676007097 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 134676007098 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 134676007099 H+ Antiporter protein; Region: 2A0121; TIGR00900 134676007100 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 134676007101 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 134676007102 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 134676007103 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 134676007104 NAD(P) binding site [chemical binding]; other site 134676007105 active site 134676007106 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 134676007107 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 134676007108 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 134676007109 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 134676007110 Walker A/P-loop; other site 134676007111 ATP binding site [chemical binding]; other site 134676007112 Q-loop/lid; other site 134676007113 ABC transporter signature motif; other site 134676007114 Walker B; other site 134676007115 D-loop; other site 134676007116 H-loop/switch region; other site 134676007117 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 134676007118 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 134676007119 Walker A/P-loop; other site 134676007120 ATP binding site [chemical binding]; other site 134676007121 Q-loop/lid; other site 134676007122 ABC transporter signature motif; other site 134676007123 Walker B; other site 134676007124 D-loop; other site 134676007125 H-loop/switch region; other site 134676007126 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 134676007127 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 134676007128 TM-ABC transporter signature motif; other site 134676007129 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 134676007130 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 134676007131 TM-ABC transporter signature motif; other site 134676007132 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 134676007133 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 134676007134 Coenzyme A transferase; Region: CoA_trans; cl17247 134676007135 Coenzyme A transferase; Region: CoA_trans; cl17247 134676007136 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 134676007137 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 134676007138 dimer interface [polypeptide binding]; other site 134676007139 active site 134676007140 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 134676007141 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 134676007142 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 134676007143 dimerization interface [polypeptide binding]; other site 134676007144 substrate binding pocket [chemical binding]; other site 134676007145 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 134676007146 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 134676007147 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 134676007148 Walker A/P-loop; other site 134676007149 ATP binding site [chemical binding]; other site 134676007150 Q-loop/lid; other site 134676007151 ABC transporter signature motif; other site 134676007152 Walker B; other site 134676007153 D-loop; other site 134676007154 H-loop/switch region; other site 134676007155 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 134676007156 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 134676007157 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 134676007158 putative dimer interface [polypeptide binding]; other site 134676007159 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 134676007160 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 134676007161 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 134676007162 catalytic residue [active] 134676007163 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 134676007164 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 134676007165 TspO/MBR family; Region: TspO_MBR; pfam03073 134676007166 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 134676007167 intracellular protease, PfpI family; Region: PfpI; TIGR01382 134676007168 proposed catalytic triad [active] 134676007169 conserved cys residue [active] 134676007170 CHASE4 domain; Region: CHASE4; cl01308 134676007171 CHASE4 domain; Region: CHASE4; cl01308 134676007172 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 134676007173 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 134676007174 dimer interface [polypeptide binding]; other site 134676007175 putative CheW interface [polypeptide binding]; other site 134676007176 siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951 134676007177 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 134676007178 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 134676007179 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676007180 WHG domain; Region: WHG; pfam13305 134676007181 short chain dehydrogenase; Provisional; Region: PRK12937 134676007182 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 134676007183 NAD(P) binding site [chemical binding]; other site 134676007184 active site 134676007185 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 134676007186 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 134676007187 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676007188 metal binding site [ion binding]; metal-binding site 134676007189 active site 134676007190 I-site; other site 134676007191 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 134676007192 DivIVA protein; Region: DivIVA; pfam05103 134676007193 DivIVA domain; Region: DivI1A_domain; TIGR03544 134676007194 PAS domain S-box; Region: sensory_box; TIGR00229 134676007195 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 134676007196 putative active site [active] 134676007197 heme pocket [chemical binding]; other site 134676007198 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 134676007199 dimer interface [polypeptide binding]; other site 134676007200 phosphorylation site [posttranslational modification] 134676007201 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676007202 ATP binding site [chemical binding]; other site 134676007203 Mg2+ binding site [ion binding]; other site 134676007204 G-X-G motif; other site 134676007205 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 134676007206 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 134676007207 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 134676007208 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 134676007209 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 134676007210 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 134676007211 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 134676007212 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 134676007213 SprT homologues; Region: SprT; cl01182 134676007214 SprT-like family; Region: SprT-like; pfam10263 134676007215 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 134676007216 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 134676007217 putative ligand binding site [chemical binding]; other site 134676007218 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 134676007219 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 134676007220 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 134676007221 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 134676007222 TM-ABC transporter signature motif; other site 134676007223 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 134676007224 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 134676007225 Walker A/P-loop; other site 134676007226 ATP binding site [chemical binding]; other site 134676007227 Q-loop/lid; other site 134676007228 ABC transporter signature motif; other site 134676007229 Walker B; other site 134676007230 D-loop; other site 134676007231 H-loop/switch region; other site 134676007232 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 134676007233 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 134676007234 non-specific DNA interactions [nucleotide binding]; other site 134676007235 DNA binding site [nucleotide binding] 134676007236 sequence specific DNA binding site [nucleotide binding]; other site 134676007237 putative cAMP binding site [chemical binding]; other site 134676007238 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 134676007239 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 134676007240 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 134676007241 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 134676007242 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 134676007243 Walker A/P-loop; other site 134676007244 ATP binding site [chemical binding]; other site 134676007245 Q-loop/lid; other site 134676007246 ABC transporter signature motif; other site 134676007247 Walker B; other site 134676007248 D-loop; other site 134676007249 H-loop/switch region; other site 134676007250 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 134676007251 dimerization interface [polypeptide binding]; other site 134676007252 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 134676007253 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 134676007254 dimer interface [polypeptide binding]; other site 134676007255 putative CheW interface [polypeptide binding]; other site 134676007256 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 134676007257 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 134676007258 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 134676007259 dimer interface [polypeptide binding]; other site 134676007260 FMN binding site [chemical binding]; other site 134676007261 NADPH bind site [chemical binding]; other site 134676007262 Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365 134676007263 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 134676007264 dimerization interface [polypeptide binding]; other site 134676007265 putative DNA binding site [nucleotide binding]; other site 134676007266 putative Zn2+ binding site [ion binding]; other site 134676007267 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 134676007268 hydrophobic ligand binding site; other site 134676007269 HIRAN domain; Region: HIRAN; pfam08797 134676007270 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 134676007271 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 134676007272 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 134676007273 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 134676007274 Ligand binding site; other site 134676007275 Putative Catalytic site; other site 134676007276 DXD motif; other site 134676007277 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 134676007278 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 134676007279 putative active site [active] 134676007280 catalytic triad [active] 134676007281 putative dimer interface [polypeptide binding]; other site 134676007282 MutL protein; Region: MutL; pfam13941 134676007283 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 134676007284 active site 2 [active] 134676007285 B12 binding domain; Region: B12-binding; pfam02310 134676007286 B12 binding site [chemical binding]; other site 134676007287 D-Lysine 5,6-aminomutase alpha subunit; Region: Lys-AminoMut_A; pfam09043 134676007288 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 134676007289 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 134676007290 active site 134676007291 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 134676007292 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 134676007293 S-adenosylmethionine binding site [chemical binding]; other site 134676007294 Short repeats of unknown function; Region: ALF; pfam03752 134676007295 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 134676007296 protein-splicing catalytic site; other site 134676007297 thioester formation/cholesterol transfer; other site 134676007298 Pretoxin HINT domain; Region: PT-HINT; pfam07591 134676007299 Putative esterase; Region: Esterase; pfam00756 134676007300 S-formylglutathione hydrolase; Region: PLN02442 134676007301 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 134676007302 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 134676007303 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 134676007304 putative DNA binding site [nucleotide binding]; other site 134676007305 putative Zn2+ binding site [ion binding]; other site 134676007306 AsnC family; Region: AsnC_trans_reg; pfam01037 134676007307 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 134676007308 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 134676007309 active site 134676007310 5'-3' exonuclease; Region: 53EXOc; smart00475 134676007311 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 134676007312 active site 134676007313 metal binding site 1 [ion binding]; metal-binding site 134676007314 putative 5' ssDNA interaction site; other site 134676007315 metal binding site 3; metal-binding site 134676007316 metal binding site 2 [ion binding]; metal-binding site 134676007317 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 134676007318 putative DNA binding site [nucleotide binding]; other site 134676007319 putative metal binding site [ion binding]; other site 134676007320 classical (c) SDRs; Region: SDR_c; cd05233 134676007321 NAD(P) binding site [chemical binding]; other site 134676007322 active site 134676007323 PRC-barrel domain; Region: PRC; pfam05239 134676007324 PRC-barrel domain; Region: PRC; pfam05239 134676007325 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 134676007326 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 134676007327 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 134676007328 Major Facilitator Superfamily; Region: MFS_1; pfam07690 134676007329 putative substrate translocation pore; other site 134676007330 Phosphoesterase family; Region: Phosphoesterase; pfam04185 134676007331 PAS domain S-box; Region: sensory_box; TIGR00229 134676007332 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 134676007333 putative active site [active] 134676007334 heme pocket [chemical binding]; other site 134676007335 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 134676007336 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676007337 metal binding site [ion binding]; metal-binding site 134676007338 active site 134676007339 I-site; other site 134676007340 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 134676007341 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 134676007342 Coenzyme A binding pocket [chemical binding]; other site 134676007343 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 134676007344 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 134676007345 active site 134676007346 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 134676007347 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676007348 metal binding site [ion binding]; metal-binding site 134676007349 active site 134676007350 I-site; other site 134676007351 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 134676007352 sugar binding site [chemical binding]; other site 134676007353 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 134676007354 Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231 134676007355 sugar binding site [chemical binding]; other site 134676007356 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 134676007357 active site 134676007358 catalytic residues [active] 134676007359 CAAX protease self-immunity; Region: Abi; pfam02517 134676007360 PhoD-like phosphatase; Region: PhoD; pfam09423 134676007361 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 134676007362 putative active site [active] 134676007363 putative metal binding site [ion binding]; other site 134676007364 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 134676007365 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 134676007366 CutA1 divalent ion tolerance protein; Region: CutA1; cl00584 134676007367 Protein of unknown function (DUF419); Region: DUF419; cl15265 134676007368 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 134676007369 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 134676007370 N-acetyl-D-glucosamine binding site [chemical binding]; other site 134676007371 catalytic residue [active] 134676007372 Protein of unknown function DUF72; Region: DUF72; pfam01904 134676007373 Domain of unknown function (DUF397); Region: DUF397; pfam04149 134676007374 Glycosyl hydrolases family 32 N-terminal domain; Region: Glyco_hydro_32N; pfam00251 134676007375 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 134676007376 active site 134676007377 Protein of unknown function (DUF1810); Region: DUF1810; pfam08837 134676007378 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 134676007379 Coenzyme A binding pocket [chemical binding]; other site 134676007380 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 134676007381 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 134676007382 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 134676007383 active site 134676007384 catalytic site [active] 134676007385 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 134676007386 Major Facilitator Superfamily; Region: MFS_1; pfam07690 134676007387 putative substrate translocation pore; other site 134676007388 Transcriptional regulators [Transcription]; Region: MarR; COG1846 134676007389 MarR family; Region: MarR_2; pfam12802 134676007390 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 134676007391 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 134676007392 active site 134676007393 catalytic tetrad [active] 134676007394 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 134676007395 Secretory lipase; Region: LIP; pfam03583 134676007396 Erythromycin esterase; Region: Erythro_esteras; pfam05139 134676007397 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 134676007398 heme-binding site [chemical binding]; other site 134676007399 Ycf46; Provisional; Region: ycf46; CHL00195 134676007400 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 134676007401 Walker A motif; other site 134676007402 ATP binding site [chemical binding]; other site 134676007403 Walker B motif; other site 134676007404 arginine finger; other site 134676007405 Protein of unknown function (DUF2997); Region: DUF2997; pfam11211 134676007406 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 134676007407 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 134676007408 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 134676007409 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 134676007410 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 134676007411 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 134676007412 Walker A/P-loop; other site 134676007413 ATP binding site [chemical binding]; other site 134676007414 Q-loop/lid; other site 134676007415 ABC transporter signature motif; other site 134676007416 Walker B; other site 134676007417 D-loop; other site 134676007418 H-loop/switch region; other site 134676007419 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 134676007420 ABC-2 type transporter; Region: ABC2_membrane; cl17235 134676007421 Bacterial transcriptional activator domain; Region: BTAD; smart01043 134676007422 AAA ATPase domain; Region: AAA_16; pfam13191 134676007423 Predicted ATPase [General function prediction only]; Region: COG3903 134676007424 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 134676007425 nudix motif; other site 134676007426 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 134676007427 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 134676007428 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 134676007429 PemK-like protein; Region: PemK; pfam02452 134676007430 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 134676007431 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 134676007432 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 134676007433 substrate binding pocket [chemical binding]; other site 134676007434 membrane-bound complex binding site; other site 134676007435 hinge residues; other site 134676007436 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 134676007437 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676007438 metal binding site [ion binding]; metal-binding site 134676007439 active site 134676007440 I-site; other site 134676007441 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 134676007442 phosphoglucomutase; Validated; Region: PRK07564 134676007443 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 134676007444 active site 134676007445 substrate binding site [chemical binding]; other site 134676007446 metal binding site [ion binding]; metal-binding site 134676007447 CopC domain; Region: CopC; pfam04234 134676007448 Methyltransferase domain; Region: Methyltransf_23; pfam13489 134676007449 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 134676007450 S-adenosylmethionine binding site [chemical binding]; other site 134676007451 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 134676007452 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 134676007453 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 134676007454 non-specific DNA binding site [nucleotide binding]; other site 134676007455 salt bridge; other site 134676007456 sequence-specific DNA binding site [nucleotide binding]; other site 134676007457 hypothetical protein; Validated; Region: PRK02101 134676007458 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 134676007459 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 134676007460 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 134676007461 Uncharacterized conserved protein (DUF2039); Region: DUF2039; pfam10217 134676007462 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 134676007463 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 134676007464 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 134676007465 active site 134676007466 Uncharacterized conserved protein [Function unknown]; Region: COG4279 134676007467 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 134676007468 SNF2 Helicase protein; Region: DUF3670; pfam12419 134676007469 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 134676007470 ATP binding site [chemical binding]; other site 134676007471 putative Mg++ binding site [ion binding]; other site 134676007472 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 134676007473 nucleotide binding region [chemical binding]; other site 134676007474 ATP-binding site [chemical binding]; other site 134676007475 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 134676007476 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676007477 metal binding site [ion binding]; metal-binding site 134676007478 active site 134676007479 I-site; other site 134676007480 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 134676007481 TPR repeat; Region: TPR_11; pfam13414 134676007482 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 134676007483 binding surface 134676007484 TPR motif; other site 134676007485 Tetratricopeptide repeat; Region: TPR_12; pfam13424 134676007486 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 134676007487 ATP-grasp domain; Region: ATP-grasp_4; cl17255 134676007488 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 134676007489 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 134676007490 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 134676007491 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 134676007492 Cytochrome P450; Region: p450; cl12078 134676007493 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 134676007494 anti sigma factor interaction site; other site 134676007495 regulatory phosphorylation site [posttranslational modification]; other site 134676007496 amino acid transporter; Region: 2A0306; TIGR00909 134676007497 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 134676007498 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 134676007499 Catalytic domain of Protein Kinases; Region: PKc; cd00180 134676007500 active site 134676007501 ATP binding site [chemical binding]; other site 134676007502 substrate binding site [chemical binding]; other site 134676007503 activation loop (A-loop); other site 134676007504 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 134676007505 active site 134676007506 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 134676007507 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 134676007508 AAA domain; Region: AAA_17; pfam13207 134676007509 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 134676007510 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 134676007511 putative active site [active] 134676007512 putative metal binding site [ion binding]; other site 134676007513 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 134676007514 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 134676007515 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 134676007516 Walker A/P-loop; other site 134676007517 ATP binding site [chemical binding]; other site 134676007518 Q-loop/lid; other site 134676007519 ABC transporter signature motif; other site 134676007520 Walker B; other site 134676007521 D-loop; other site 134676007522 H-loop/switch region; other site 134676007523 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 134676007524 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 134676007525 Walker A/P-loop; other site 134676007526 ATP binding site [chemical binding]; other site 134676007527 Q-loop/lid; other site 134676007528 ABC transporter signature motif; other site 134676007529 Walker B; other site 134676007530 D-loop; other site 134676007531 H-loop/switch region; other site 134676007532 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 134676007533 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 134676007534 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 134676007535 Methyltransferase domain; Region: Methyltransf_23; pfam13489 134676007536 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 134676007537 S-adenosylmethionine binding site [chemical binding]; other site 134676007538 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 134676007539 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 134676007540 FAD binding pocket [chemical binding]; other site 134676007541 FAD binding motif [chemical binding]; other site 134676007542 phosphate binding motif [ion binding]; other site 134676007543 beta-alpha-beta structure motif; other site 134676007544 NAD(p) ribose binding residues [chemical binding]; other site 134676007545 NAD binding pocket [chemical binding]; other site 134676007546 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 134676007547 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 134676007548 catalytic loop [active] 134676007549 iron binding site [ion binding]; other site 134676007550 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 134676007551 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 134676007552 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 134676007553 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 134676007554 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 134676007555 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 134676007556 phenylacetic acid degradation protein paaN; Region: PaaN_2; TIGR02288 134676007557 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 134676007558 NAD(P) binding site [chemical binding]; other site 134676007559 catalytic residues [active] 134676007560 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 134676007561 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676007562 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 134676007563 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 134676007564 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 134676007565 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 134676007566 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 134676007567 Walker A/P-loop; other site 134676007568 ATP binding site [chemical binding]; other site 134676007569 Q-loop/lid; other site 134676007570 ABC transporter signature motif; other site 134676007571 Walker B; other site 134676007572 D-loop; other site 134676007573 H-loop/switch region; other site 134676007574 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 134676007575 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 134676007576 TM-ABC transporter signature motif; other site 134676007577 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 134676007578 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 134676007579 putative ligand binding site [chemical binding]; other site 134676007580 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 134676007581 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 134676007582 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 134676007583 PYR/PP interface [polypeptide binding]; other site 134676007584 dimer interface [polypeptide binding]; other site 134676007585 TPP binding site [chemical binding]; other site 134676007586 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 134676007587 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 134676007588 TPP-binding site; other site 134676007589 KduI/IolB family; Region: KduI; pfam04962 134676007590 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 134676007591 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 134676007592 substrate binding site [chemical binding]; other site 134676007593 ATP binding site [chemical binding]; other site 134676007594 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 134676007595 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 134676007596 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 134676007597 putative active site [active] 134676007598 metal binding site [ion binding]; metal-binding site 134676007599 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 134676007600 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 134676007601 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 134676007602 DNA binding residues [nucleotide binding] 134676007603 dimerization interface [polypeptide binding]; other site 134676007604 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 134676007605 FtsX-like permease family; Region: FtsX; pfam02687 134676007606 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 134676007607 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 134676007608 Walker A/P-loop; other site 134676007609 ATP binding site [chemical binding]; other site 134676007610 Q-loop/lid; other site 134676007611 ABC transporter signature motif; other site 134676007612 Walker B; other site 134676007613 D-loop; other site 134676007614 H-loop/switch region; other site 134676007615 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 134676007616 HlyD family secretion protein; Region: HlyD_3; pfam13437 134676007617 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 134676007618 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 134676007619 dimerization interface [polypeptide binding]; other site 134676007620 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 134676007621 dimer interface [polypeptide binding]; other site 134676007622 phosphorylation site [posttranslational modification] 134676007623 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676007624 ATP binding site [chemical binding]; other site 134676007625 Mg2+ binding site [ion binding]; other site 134676007626 G-X-G motif; other site 134676007627 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 134676007628 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676007629 active site 134676007630 phosphorylation site [posttranslational modification] 134676007631 intermolecular recognition site; other site 134676007632 dimerization interface [polypeptide binding]; other site 134676007633 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 134676007634 DNA binding site [nucleotide binding] 134676007635 HlyD family secretion protein; Region: HlyD_3; pfam13437 134676007636 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 134676007637 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 134676007638 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 134676007639 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 134676007640 DNA binding residues [nucleotide binding] 134676007641 dimerization interface [polypeptide binding]; other site 134676007642 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 134676007643 catalytic core [active] 134676007644 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 134676007645 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 134676007646 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 134676007647 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 134676007648 Transcriptional regulators [Transcription]; Region: PurR; COG1609 134676007649 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 134676007650 DNA binding site [nucleotide binding] 134676007651 domain linker motif; other site 134676007652 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 134676007653 Transcriptional regulators [Transcription]; Region: PurR; COG1609 134676007654 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 134676007655 dimerization interface [polypeptide binding]; other site 134676007656 ligand binding site [chemical binding]; other site 134676007657 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 134676007658 Transcriptional regulators [Transcription]; Region: MarR; COG1846 134676007659 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 134676007660 putative DNA binding site [nucleotide binding]; other site 134676007661 putative Zn2+ binding site [ion binding]; other site 134676007662 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 134676007663 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 134676007664 Protein of unknown function (DUF3072); Region: DUF3072; pfam11272 134676007665 Domain of unknown function (DUF385); Region: DUF385; pfam04075 134676007666 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 134676007667 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 134676007668 Walker A/P-loop; other site 134676007669 ATP binding site [chemical binding]; other site 134676007670 Q-loop/lid; other site 134676007671 ABC transporter signature motif; other site 134676007672 Walker B; other site 134676007673 D-loop; other site 134676007674 H-loop/switch region; other site 134676007675 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 134676007676 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 134676007677 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 134676007678 Walker A/P-loop; other site 134676007679 ATP binding site [chemical binding]; other site 134676007680 Q-loop/lid; other site 134676007681 ABC transporter signature motif; other site 134676007682 Walker B; other site 134676007683 D-loop; other site 134676007684 H-loop/switch region; other site 134676007685 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 134676007686 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 134676007687 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 134676007688 dimer interface [polypeptide binding]; other site 134676007689 conserved gate region; other site 134676007690 putative PBP binding loops; other site 134676007691 ABC-ATPase subunit interface; other site 134676007692 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 134676007693 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 134676007694 dimer interface [polypeptide binding]; other site 134676007695 conserved gate region; other site 134676007696 putative PBP binding loops; other site 134676007697 ABC-ATPase subunit interface; other site 134676007698 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 134676007699 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 134676007700 substrate binding site [chemical binding]; other site 134676007701 Response regulator receiver domain; Region: Response_reg; pfam00072 134676007702 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676007703 active site 134676007704 phosphorylation site [posttranslational modification] 134676007705 intermolecular recognition site; other site 134676007706 dimerization interface [polypeptide binding]; other site 134676007707 RecA-superfamily ATPases implicated in signal transduction [Signal transduction mechanisms]; Region: RAD55; COG0467 134676007708 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 134676007709 ATP binding site [chemical binding]; other site 134676007710 Walker A motif; other site 134676007711 Walker B motif; other site 134676007712 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 134676007713 KaiC; Region: KaiC; pfam06745 134676007714 Walker A motif; other site 134676007715 ATP binding site [chemical binding]; other site 134676007716 Walker B motif; other site 134676007717 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 134676007718 S-adenosylmethionine binding site [chemical binding]; other site 134676007719 Isochorismatase family; Region: Isochorismatase; pfam00857 134676007720 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 134676007721 catalytic triad [active] 134676007722 conserved cis-peptide bond; other site 134676007723 Transcriptional regulators [Transcription]; Region: PurR; COG1609 134676007724 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 134676007725 DNA binding site [nucleotide binding] 134676007726 domain linker motif; other site 134676007727 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 134676007728 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 134676007729 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 134676007730 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 134676007731 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676007732 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 134676007733 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676007734 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 134676007735 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 134676007736 LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037 134676007737 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 134676007738 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 134676007739 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 134676007740 Catalytic domain of Protein Kinases; Region: PKc; cd00180 134676007741 active site 134676007742 ATP binding site [chemical binding]; other site 134676007743 substrate binding site [chemical binding]; other site 134676007744 activation loop (A-loop); other site 134676007745 RibD C-terminal domain; Region: RibD_C; cl17279 134676007746 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 134676007747 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 134676007748 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 134676007749 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 134676007750 putative active site [active] 134676007751 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 134676007752 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 134676007753 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 134676007754 active site 134676007755 dimer interface [polypeptide binding]; other site 134676007756 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 134676007757 dimer interface [polypeptide binding]; other site 134676007758 active site 134676007759 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 134676007760 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 134676007761 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 134676007762 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 134676007763 active site 134676007764 dimer interface [polypeptide binding]; other site 134676007765 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 134676007766 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 134676007767 Putative cyclase; Region: Cyclase; cl00814 134676007768 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 134676007769 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 134676007770 DNA binding residues [nucleotide binding] 134676007771 Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699 134676007772 marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788 134676007773 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 134676007774 metal ion-dependent adhesion site (MIDAS); other site 134676007775 Transposase, Mutator family; Region: Transposase_mut; pfam00872 134676007776 MULE transposase domain; Region: MULE; pfam10551 134676007777 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 134676007778 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 134676007779 putative sugar binding sites [chemical binding]; other site 134676007780 Q-X-W motif; other site 134676007781 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 134676007782 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 134676007783 active site 134676007784 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 134676007785 L-lactate permease; Region: Lactate_perm; cl00701 134676007786 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 134676007787 L-lactate permease; Region: Lactate_perm; cl00701 134676007788 CHASE3 domain; Region: CHASE3; pfam05227 134676007789 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 134676007790 dimer interface [polypeptide binding]; other site 134676007791 phosphorylation site [posttranslational modification] 134676007792 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676007793 ATP binding site [chemical binding]; other site 134676007794 Mg2+ binding site [ion binding]; other site 134676007795 G-X-G motif; other site 134676007796 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; cl09823 134676007797 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 134676007798 sugar binding site [chemical binding]; other site 134676007799 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 134676007800 sugar binding site [chemical binding]; other site 134676007801 Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231 134676007802 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 134676007803 sugar binding site [chemical binding]; other site 134676007804 Kelch domain; Region: Kelch; smart00612 134676007805 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 134676007806 C-terminal Early set domain associated with the catalytic domain of galactose oxidase; Region: E_set_GO_C; cd02851 134676007807 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 134676007808 Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041 134676007809 DivIVA protein; Region: DivIVA; pfam05103 134676007810 Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270 134676007811 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 134676007812 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 134676007813 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 134676007814 putative sugar binding sites [chemical binding]; other site 134676007815 Q-X-W motif; other site 134676007816 Glycosyl hydrolase family 62, characterized arabinofuranosidases; Region: GH62; cd08987 134676007817 active site 134676007818 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 134676007819 Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270 134676007820 Cellulose binding domain; Region: CBM_2; pfam00553 134676007821 Glycosyl hydrolase family 62; Region: Glyco_hydro_62; pfam03664 134676007822 active site 134676007823 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 134676007824 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 134676007825 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 134676007826 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 134676007827 putative sugar binding sites [chemical binding]; other site 134676007828 Q-X-W motif; other site 134676007829 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 134676007830 substrate binding site [chemical binding]; other site 134676007831 active site 134676007832 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 134676007833 metal binding site [ion binding]; metal-binding site 134676007834 ligand binding site [chemical binding]; other site 134676007835 alpha-galactosidase; Region: PLN02808; cl17638 134676007836 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 134676007837 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 134676007838 putative sugar binding sites [chemical binding]; other site 134676007839 Q-X-W motif; other site 134676007840 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 134676007841 Cellulose binding domain; Region: CBM_2; cl17741 134676007842 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 134676007843 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 134676007844 Cellulose binding domain; Region: CBM_2; pfam00553 134676007845 CBD_II domain; Region: CBD_II; smart00637 134676007846 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 134676007847 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 134676007848 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 134676007849 motif II; other site 134676007850 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 134676007851 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 134676007852 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 134676007853 putative sugar binding sites [chemical binding]; other site 134676007854 Q-X-W motif; other site 134676007855 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 134676007856 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 134676007857 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 134676007858 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 134676007859 dimer interface [polypeptide binding]; other site 134676007860 phosphorylation site [posttranslational modification] 134676007861 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676007862 ATP binding site [chemical binding]; other site 134676007863 Mg2+ binding site [ion binding]; other site 134676007864 G-X-G motif; other site 134676007865 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 134676007866 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676007867 active site 134676007868 phosphorylation site [posttranslational modification] 134676007869 intermolecular recognition site; other site 134676007870 dimerization interface [polypeptide binding]; other site 134676007871 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 134676007872 DNA binding site [nucleotide binding] 134676007873 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 134676007874 Global regulator protein family; Region: CsrA; cl00670 134676007875 alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175 134676007876 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 134676007877 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 134676007878 pyridoxal 5'-phosphate binding site [chemical binding]; other site 134676007879 catalytic residue [active] 134676007880 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 134676007881 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 134676007882 substrate binding site [chemical binding]; other site 134676007883 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 134676007884 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 134676007885 DNA-binding site [nucleotide binding]; DNA binding site 134676007886 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 134676007887 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 134676007888 Domain of unknown function (DUF4265); Region: DUF4265; pfam14085 134676007889 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 134676007890 active site 134676007891 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 134676007892 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 134676007893 ATP binding site [chemical binding]; other site 134676007894 Walker B motif; other site 134676007895 arginine finger; other site 134676007896 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 134676007897 NlpC/P60 family; Region: NLPC_P60; pfam00877 134676007898 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 134676007899 Penicillinase repressor; Region: Pencillinase_R; pfam03965 134676007900 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 134676007901 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 134676007902 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 134676007903 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 134676007904 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 134676007905 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 134676007906 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 134676007907 Walker A/P-loop; other site 134676007908 ATP binding site [chemical binding]; other site 134676007909 Q-loop/lid; other site 134676007910 ABC transporter signature motif; other site 134676007911 Walker B; other site 134676007912 D-loop; other site 134676007913 H-loop/switch region; other site 134676007914 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 134676007915 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 134676007916 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 134676007917 Walker A/P-loop; other site 134676007918 ATP binding site [chemical binding]; other site 134676007919 ABC transporter signature motif; other site 134676007920 Walker B; other site 134676007921 D-loop; other site 134676007922 H-loop/switch region; other site 134676007923 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 134676007924 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676007925 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 134676007926 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 134676007927 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 134676007928 dimerization interface [polypeptide binding]; other site 134676007929 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 134676007930 dimer interface [polypeptide binding]; other site 134676007931 putative CheW interface [polypeptide binding]; other site 134676007932 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 134676007933 dihydropteroate synthase; Region: DHPS; TIGR01496 134676007934 substrate binding pocket [chemical binding]; other site 134676007935 dimer interface [polypeptide binding]; other site 134676007936 inhibitor binding site; inhibition site 134676007937 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 134676007938 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 134676007939 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 134676007940 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676007941 H+ Antiporter protein; Region: 2A0121; TIGR00900 134676007942 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 134676007943 dimerization interface [polypeptide binding]; other site 134676007944 putative DNA binding site [nucleotide binding]; other site 134676007945 putative Zn2+ binding site [ion binding]; other site 134676007946 Protein of unknown function (DUF4241); Region: DUF4241; pfam14025 134676007947 PQQ-like domain; Region: PQQ_2; pfam13360 134676007948 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl17353 134676007949 fructuronate transporter; Provisional; Region: PRK10034; cl15264 134676007950 MarR family; Region: MarR_2; pfam12802 134676007951 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 134676007952 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 134676007953 short chain dehydrogenase; Validated; Region: PRK08264 134676007954 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 134676007955 NAD(P) binding site [chemical binding]; other site 134676007956 active site 134676007957 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676007958 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 134676007959 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676007960 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 134676007961 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 134676007962 heat shock protein 90; Provisional; Region: PRK05218 134676007963 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676007964 ATP binding site [chemical binding]; other site 134676007965 Mg2+ binding site [ion binding]; other site 134676007966 G-X-G motif; other site 134676007967 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 134676007968 Predicted membrane protein [Function unknown]; Region: COG4709 134676007969 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 134676007970 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 134676007971 intersubunit interface [polypeptide binding]; other site 134676007972 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 134676007973 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 134676007974 putative NAD(P) binding site [chemical binding]; other site 134676007975 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 134676007976 active site 134676007977 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 134676007978 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 134676007979 Methyltransferase domain; Region: Methyltransf_12; pfam08242 134676007980 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 134676007981 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 134676007982 RibD C-terminal domain; Region: RibD_C; cl17279 134676007983 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 134676007984 dimerization interface [polypeptide binding]; other site 134676007985 active site 134676007986 PAS fold; Region: PAS_4; pfam08448 134676007987 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 134676007988 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 134676007989 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 134676007990 ATP binding site [chemical binding]; other site 134676007991 Mg2+ binding site [ion binding]; other site 134676007992 G-X-G motif; other site 134676007993 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 134676007994 anti sigma factor interaction site; other site 134676007995 regulatory phosphorylation site [posttranslational modification]; other site 134676007996 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 134676007997 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 134676007998 ATP binding site [chemical binding]; other site 134676007999 putative Mg++ binding site [ion binding]; other site 134676008000 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 134676008001 nucleotide binding region [chemical binding]; other site 134676008002 ATP-binding site [chemical binding]; other site 134676008003 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 134676008004 HRDC domain; Region: HRDC; pfam00570 134676008005 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 134676008006 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 134676008007 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 134676008008 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 134676008009 dimer interface [polypeptide binding]; other site 134676008010 pyruvate phosphate dikinase; Provisional; Region: PRK09279 134676008011 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 134676008012 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 134676008013 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 134676008014 FAD binding domain; Region: FAD_binding_4; pfam01565 134676008015 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 134676008016 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 134676008017 FAD binding domain; Region: FAD_binding_4; pfam01565 134676008018 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 134676008019 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 134676008020 Cysteine-rich domain; Region: CCG; pfam02754 134676008021 Cysteine-rich domain; Region: CCG; pfam02754 134676008022 MMPL family; Region: MMPL; pfam03176 134676008023 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 134676008024 SmpB-tmRNA interface; other site 134676008025 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 134676008026 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 134676008027 putative ligand binding site [chemical binding]; other site 134676008028 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 134676008029 tetramerization interface [polypeptide binding]; other site 134676008030 NAD(P) binding site [chemical binding]; other site 134676008031 catalytic residues [active] 134676008032 low sequence quality region; could not be amplified with PCR 134676008033 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 134676008034 dimerization interface [polypeptide binding]; other site 134676008035 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 134676008036 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 134676008037 putative CheW interface [polypeptide binding]; other site 134676008038 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 134676008039 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 134676008040 putative ligand binding site [chemical binding]; other site 134676008041 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 134676008042 active site 134676008043 ATP binding site [chemical binding]; other site 134676008044 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 134676008045 Catalytic domain of Protein Kinases; Region: PKc; cd00180 134676008046 substrate binding site [chemical binding]; other site 134676008047 activation loop (A-loop); other site 134676008048 Predicted ATPase [General function prediction only]; Region: COG3899 134676008049 AAA ATPase domain; Region: AAA_16; pfam13191 134676008050 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 134676008051 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 134676008052 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 134676008053 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 134676008054 dimer interface [polypeptide binding]; other site 134676008055 phosphorylation site [posttranslational modification] 134676008056 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676008057 ATP binding site [chemical binding]; other site 134676008058 Mg2+ binding site [ion binding]; other site 134676008059 G-X-G motif; other site 134676008060 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 134676008061 NADH(P)-binding; Region: NAD_binding_10; pfam13460 134676008062 NAD(P) binding site [chemical binding]; other site 134676008063 active site 134676008064 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 134676008065 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 134676008066 NADP binding site [chemical binding]; other site 134676008067 active site 134676008068 putative substrate binding site [chemical binding]; other site 134676008069 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 134676008070 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 134676008071 NAD binding site [chemical binding]; other site 134676008072 substrate binding site [chemical binding]; other site 134676008073 homodimer interface [polypeptide binding]; other site 134676008074 active site 134676008075 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 134676008076 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 134676008077 substrate binding site; other site 134676008078 tetramer interface; other site 134676008079 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 134676008080 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 134676008081 Bacterial sugar transferase; Region: Bac_transf; pfam02397 134676008082 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 134676008083 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 134676008084 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 134676008085 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 134676008086 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 134676008087 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 134676008088 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 134676008089 Probable Catalytic site; other site 134676008090 metal-binding site 134676008091 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 134676008092 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 134676008093 putative DNA binding site [nucleotide binding]; other site 134676008094 putative Zn2+ binding site [ion binding]; other site 134676008095 AsnC family; Region: AsnC_trans_reg; pfam01037 134676008096 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 134676008097 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 134676008098 putative active site [active] 134676008099 putative metal binding site [ion binding]; other site 134676008100 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 134676008101 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 134676008102 DXD motif; other site 134676008103 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 134676008104 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 134676008105 Chain length determinant protein; Region: Wzz; cl15801 134676008106 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 134676008107 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 134676008108 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 134676008109 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 134676008110 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 134676008111 active site 134676008112 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 134676008113 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 134676008114 Bacterial Ig-like domain; Region: Big_5; pfam13205 134676008115 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 134676008116 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 134676008117 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 134676008118 active site 134676008119 NRPS 134676008120 H+ Antiporter protein; Region: 2A0121; TIGR00900 134676008121 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 134676008122 putative substrate translocation pore; other site 134676008123 Condensation domain; Region: Condensation; pfam00668 134676008124 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 134676008125 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 134676008126 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 134676008127 acyl-activating enzyme (AAE) consensus motif; other site 134676008128 AMP binding site [chemical binding]; other site 134676008129 Condensation domain; Region: Condensation; pfam00668 134676008130 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 134676008131 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 134676008132 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 134676008133 acyl-activating enzyme (AAE) consensus motif; other site 134676008134 AMP binding site [chemical binding]; other site 134676008135 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 134676008136 Condensation domain; Region: Condensation; pfam00668 134676008137 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 134676008138 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 134676008139 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 134676008140 acyl-activating enzyme (AAE) consensus motif; other site 134676008141 AMP binding site [chemical binding]; other site 134676008142 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 134676008143 thioester reductase domain; Region: Thioester-redct; TIGR01746 134676008144 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 134676008145 putative NAD(P) binding site [chemical binding]; other site 134676008146 active site 134676008147 putative substrate binding site [chemical binding]; other site 134676008148 Condensation domain; Region: Condensation; pfam00668 134676008149 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 134676008150 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 134676008151 acyl-activating enzyme (AAE) consensus motif; other site 134676008152 AMP binding site [chemical binding]; other site 134676008153 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 134676008154 Condensation domain; Region: Condensation; pfam00668 134676008155 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 134676008156 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 134676008157 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 134676008158 acyl-activating enzyme (AAE) consensus motif; other site 134676008159 AMP binding site [chemical binding]; other site 134676008160 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 134676008161 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 134676008162 Secretory lipase; Region: LIP; pfam03583 134676008163 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508 134676008164 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 134676008165 E3 interaction surface; other site 134676008166 lipoyl attachment site [posttranslational modification]; other site 134676008167 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 134676008168 putative trimer interface [polypeptide binding]; other site 134676008169 putative CoA binding site [chemical binding]; other site 134676008170 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 134676008171 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 134676008172 PYR/PP interface [polypeptide binding]; other site 134676008173 dimer interface [polypeptide binding]; other site 134676008174 TPP binding site [chemical binding]; other site 134676008175 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 134676008176 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 134676008177 tetramer interface [polypeptide binding]; other site 134676008178 TPP-binding site [chemical binding]; other site 134676008179 heterodimer interface [polypeptide binding]; other site 134676008180 phosphorylation loop region [posttranslational modification] 134676008181 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 134676008182 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 134676008183 inhibitor-cofactor binding pocket; inhibition site 134676008184 pyridoxal 5'-phosphate binding site [chemical binding]; other site 134676008185 catalytic residue [active] 134676008186 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 134676008187 Major Facilitator Superfamily; Region: MFS_1; pfam07690 134676008188 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 134676008189 translocation protein TolB; Provisional; Region: tolB; PRK01029 134676008190 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 134676008191 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 134676008192 Bacterial transferase hexapeptide (six repeats); Region: Hexapep; pfam00132 134676008193 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 134676008194 putative trimer interface [polypeptide binding]; other site 134676008195 putative active site [active] 134676008196 putative substrate binding site [chemical binding]; other site 134676008197 putative CoA binding site [chemical binding]; other site 134676008198 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 134676008199 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 134676008200 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 134676008201 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 134676008202 NAD(P) binding site [chemical binding]; other site 134676008203 active site 134676008204 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 134676008205 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 134676008206 inhibitor-cofactor binding pocket; inhibition site 134676008207 pyridoxal 5'-phosphate binding site [chemical binding]; other site 134676008208 catalytic residue [active] 134676008209 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 134676008210 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 134676008211 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 134676008212 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 134676008213 Methyltransferase domain; Region: Methyltransf_31; pfam13847 134676008214 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 134676008215 S-adenosylmethionine binding site [chemical binding]; other site 134676008216 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 134676008217 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 134676008218 nucleotide binding pocket [chemical binding]; other site 134676008219 K-X-D-G motif; other site 134676008220 catalytic site [active] 134676008221 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 134676008222 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 134676008223 Dimer interface [polypeptide binding]; other site 134676008224 hydroperoxidase II; Provisional; Region: katE; PRK11249 134676008225 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 134676008226 heme binding pocket [chemical binding]; other site 134676008227 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 134676008228 domain interactions; other site 134676008229 putative acetyltransferase; Provisional; Region: PRK03624 134676008230 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 134676008231 Coenzyme A binding pocket [chemical binding]; other site 134676008232 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 134676008233 FAD binding domain; Region: FAD_binding_4; pfam01565 134676008234 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 134676008235 sn-glycerol-3-phosphate dehydrogenase subunit C; Provisional; Region: glpC; PRK11168 134676008236 Tetratricopeptide repeat; Region: TPR_12; pfam13424 134676008237 NACHT domain; Region: NACHT; pfam05729 134676008238 2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745 134676008239 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 134676008240 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 134676008241 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 134676008242 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 134676008243 dimer interface [polypeptide binding]; other site 134676008244 active site 134676008245 heme binding site [chemical binding]; other site 134676008246 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 134676008247 heme binding site [chemical binding]; other site 134676008248 TIR domain; Region: TIR_2; cl17458 134676008249 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 134676008250 FOG: WD40 repeat [General function prediction only]; Region: COG2319 134676008251 structural tetrad; other site 134676008252 FOG: WD40 repeat [General function prediction only]; Region: COG2319 134676008253 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 134676008254 structural tetrad; other site 134676008255 Phosphotransferase enzyme family; Region: APH; pfam01636 134676008256 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 134676008257 active site 134676008258 substrate binding site [chemical binding]; other site 134676008259 ATP binding site [chemical binding]; other site 134676008260 Uncharacterized conserved protein (COG2071); Region: DUF2071; pfam09844 134676008261 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 134676008262 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676008263 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 134676008264 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 134676008265 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 134676008266 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 134676008267 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 134676008268 ATP-grasp domain; Region: ATP-grasp_4; cl17255 134676008269 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 134676008270 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 134676008271 carboxyltransferase (CT) interaction site; other site 134676008272 biotinylation site [posttranslational modification]; other site 134676008273 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 134676008274 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 134676008275 active site 134676008276 putative pectinesterase; Region: PLN02432; cl01911 134676008277 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 134676008278 Catalytic domain of Protein Kinases; Region: PKc; cd00180 134676008279 active site 134676008280 ATP binding site [chemical binding]; other site 134676008281 substrate binding site [chemical binding]; other site 134676008282 activation loop (A-loop); other site 134676008283 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 134676008284 Cytochrome P450; Region: p450; cl12078 134676008285 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 134676008286 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 134676008287 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 134676008288 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 134676008289 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 134676008290 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 134676008291 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 134676008292 S-adenosylmethionine binding site [chemical binding]; other site 134676008293 Domain of unknown function (DUF1768); Region: DUF1768; pfam08719 134676008294 DDE superfamily endonuclease; Region: DDE_5; pfam13546 134676008295 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 134676008296 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 134676008297 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 134676008298 active site 134676008299 non-prolyl cis peptide bond; other site 134676008300 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 134676008301 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 134676008302 putative substrate translocation pore; other site 134676008303 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 134676008304 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 134676008305 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 134676008306 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 134676008307 putative sugar binding sites [chemical binding]; other site 134676008308 Q-X-W motif; other site 134676008309 CAAX protease self-immunity; Region: Abi; pfam02517 134676008310 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 134676008311 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 134676008312 HEAT repeats; Region: HEAT_2; pfam13646 134676008313 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 134676008314 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 134676008315 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 134676008316 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 134676008317 NAD(P) binding site [chemical binding]; other site 134676008318 active site 134676008319 Histidine kinase; Region: HisKA_3; pfam07730 134676008320 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 134676008321 ATP binding site [chemical binding]; other site 134676008322 Mg2+ binding site [ion binding]; other site 134676008323 G-X-G motif; other site 134676008324 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 134676008325 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676008326 active site 134676008327 phosphorylation site [posttranslational modification] 134676008328 intermolecular recognition site; other site 134676008329 dimerization interface [polypeptide binding]; other site 134676008330 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 134676008331 DNA binding residues [nucleotide binding] 134676008332 dimerization interface [polypeptide binding]; other site 134676008333 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 134676008334 YcaO-like family; Region: YcaO; pfam02624 134676008335 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 134676008336 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 134676008337 FMN binding site [chemical binding]; other site 134676008338 dimer interface [polypeptide binding]; other site 134676008339 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 134676008340 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 134676008341 active site 134676008342 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 134676008343 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 134676008344 putative active site [active] 134676008345 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 134676008346 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 134676008347 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 134676008348 putative active site [active] 134676008349 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 134676008350 Beta-lactamase; Region: Beta-lactamase; pfam00144 134676008351 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 134676008352 carbohydrate ABC transporter, N-acetylglucosamine/diacetylchitobiose-binding protein; Region: chitin_NgcE; TIGR03851 134676008353 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 134676008354 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 134676008355 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 134676008356 putative PBP binding loops; other site 134676008357 dimer interface [polypeptide binding]; other site 134676008358 ABC-ATPase subunit interface; other site 134676008359 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 134676008360 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 134676008361 dimer interface [polypeptide binding]; other site 134676008362 conserved gate region; other site 134676008363 putative PBP binding loops; other site 134676008364 ABC-ATPase subunit interface; other site 134676008365 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 134676008366 anti sigma factor interaction site; other site 134676008367 regulatory phosphorylation site [posttranslational modification]; other site 134676008368 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 134676008369 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 134676008370 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 134676008371 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 134676008372 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 134676008373 MarR family; Region: MarR_2; pfam12802 134676008374 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 134676008375 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 134676008376 dimer interface [polypeptide binding]; other site 134676008377 phosphorylation site [posttranslational modification] 134676008378 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676008379 ATP binding site [chemical binding]; other site 134676008380 Mg2+ binding site [ion binding]; other site 134676008381 G-X-G motif; other site 134676008382 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 134676008383 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676008384 active site 134676008385 phosphorylation site [posttranslational modification] 134676008386 intermolecular recognition site; other site 134676008387 dimerization interface [polypeptide binding]; other site 134676008388 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 134676008389 DNA binding site [nucleotide binding] 134676008390 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 134676008391 active site 134676008392 substrate binding sites [chemical binding]; other site 134676008393 Transcriptional regulator [Transcription]; Region: LysR; COG0583 134676008394 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 134676008395 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 134676008396 putative dimerization interface [polypeptide binding]; other site 134676008397 EamA-like transporter family; Region: EamA; pfam00892 134676008398 Cutinase; Region: Cutinase; pfam01083 134676008399 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 134676008400 extended (e) SDRs; Region: SDR_e; cd08946 134676008401 NAD(P) binding site [chemical binding]; other site 134676008402 active site 134676008403 substrate binding site [chemical binding]; other site 134676008404 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 134676008405 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 134676008406 Walker A/P-loop; other site 134676008407 ATP binding site [chemical binding]; other site 134676008408 Q-loop/lid; other site 134676008409 ABC transporter signature motif; other site 134676008410 Walker B; other site 134676008411 D-loop; other site 134676008412 H-loop/switch region; other site 134676008413 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 134676008414 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 134676008415 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 134676008416 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 134676008417 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 134676008418 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 134676008419 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676008420 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 134676008421 metal ion-dependent adhesion site (MIDAS); other site 134676008422 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 134676008423 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676008424 active site 134676008425 phosphorylation site [posttranslational modification] 134676008426 intermolecular recognition site; other site 134676008427 dimerization interface [polypeptide binding]; other site 134676008428 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 134676008429 DNA binding residues [nucleotide binding] 134676008430 Putative sensor; Region: Sensor; pfam13796 134676008431 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 134676008432 Histidine kinase; Region: HisKA_3; pfam07730 134676008433 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676008434 ATP binding site [chemical binding]; other site 134676008435 Mg2+ binding site [ion binding]; other site 134676008436 G-X-G motif; other site 134676008437 Beta-lactamase; Region: Beta-lactamase; pfam00144 134676008438 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 134676008439 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 134676008440 CoA-transferase family III; Region: CoA_transf_3; pfam02515 134676008441 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 134676008442 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 134676008443 NAD(P) binding site [chemical binding]; other site 134676008444 active site 134676008445 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 134676008446 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 134676008447 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 134676008448 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 134676008449 CHAT domain; Region: CHAT; cl17868 134676008450 CAAX protease self-immunity; Region: Abi; pfam02517 134676008451 RIP homotypic interaction motif; Region: RHIM; pfam12721 134676008452 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 134676008453 GAF domain; Region: GAF; cl17456 134676008454 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 134676008455 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 134676008456 TAP-like protein; Region: Abhydrolase_4; pfam08386 134676008457 Transcriptional regulator [Transcription]; Region: IclR; COG1414 134676008458 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 134676008459 Bacterial transcriptional regulator; Region: IclR; pfam01614 134676008460 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 134676008461 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 134676008462 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 134676008463 active site 134676008464 catalytic residues [active] 134676008465 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 134676008466 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 134676008467 putative sugar binding sites [chemical binding]; other site 134676008468 Q-X-W motif; other site 134676008469 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 134676008470 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 134676008471 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 134676008472 anti sigma factor interaction site; other site 134676008473 regulatory phosphorylation site [posttranslational modification]; other site 134676008474 C-terminal Early set domain associated with the catalytic domain of galactose oxidase; Region: E_set_GO_C; cd02851 134676008475 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 134676008476 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 134676008477 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 134676008478 active site 134676008479 GtrA-like protein; Region: GtrA; pfam04138 134676008480 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 134676008481 Predicted transcriptional regulators [Transcription]; Region: COG1695 134676008482 Transcriptional regulator PadR-like family; Region: PadR; cl17335 134676008483 Predicted flavoprotein [General function prediction only]; Region: COG0431 134676008484 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 134676008485 YCII-related domain; Region: YCII; cl00999 134676008486 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 134676008487 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 134676008488 Photosystem II reaction centre I protein (PSII 4.8 kDa protein); Region: PsbI; cl03640 134676008489 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 134676008490 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676008491 metal binding site [ion binding]; metal-binding site 134676008492 active site 134676008493 I-site; other site 134676008494 Helix-turn-helix domain; Region: HTH_18; pfam12833 134676008495 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 134676008496 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 134676008497 putative dimer interface [polypeptide binding]; other site 134676008498 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 134676008499 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 134676008500 hypothetical protein; Provisional; Region: PRK07236 134676008501 hypothetical protein; Validated; Region: PRK05868 134676008502 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 134676008503 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 134676008504 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 134676008505 dimer interface [polypeptide binding]; other site 134676008506 putative anticodon binding site; other site 134676008507 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 134676008508 motif 1; other site 134676008509 dimer interface [polypeptide binding]; other site 134676008510 active site 134676008511 motif 2; other site 134676008512 motif 3; other site 134676008513 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 134676008514 active site 134676008515 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 134676008516 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 134676008517 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676008518 active site 134676008519 phosphorylation site [posttranslational modification] 134676008520 intermolecular recognition site; other site 134676008521 dimerization interface [polypeptide binding]; other site 134676008522 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 134676008523 DNA binding site [nucleotide binding] 134676008524 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 134676008525 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 134676008526 dimerization interface [polypeptide binding]; other site 134676008527 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 134676008528 dimer interface [polypeptide binding]; other site 134676008529 phosphorylation site [posttranslational modification] 134676008530 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676008531 ATP binding site [chemical binding]; other site 134676008532 Mg2+ binding site [ion binding]; other site 134676008533 G-X-G motif; other site 134676008534 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 134676008535 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 134676008536 active site 134676008537 catalytic tetrad [active] 134676008538 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 134676008539 Penicillinase repressor; Region: Pencillinase_R; cl17580 134676008540 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 134676008541 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 134676008542 Walker A/P-loop; other site 134676008543 ATP binding site [chemical binding]; other site 134676008544 Q-loop/lid; other site 134676008545 ABC transporter signature motif; other site 134676008546 Walker B; other site 134676008547 D-loop; other site 134676008548 H-loop/switch region; other site 134676008549 Predicted transcriptional regulators [Transcription]; Region: COG1695 134676008550 Transcriptional regulator PadR-like family; Region: PadR; cl17335 134676008551 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 134676008552 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 134676008553 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 134676008554 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 134676008555 motif II; other site 134676008556 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 134676008557 pyridoxamine kinase; Validated; Region: PRK05756 134676008558 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 134676008559 dimer interface [polypeptide binding]; other site 134676008560 pyridoxal binding site [chemical binding]; other site 134676008561 ATP binding site [chemical binding]; other site 134676008562 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 134676008563 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 134676008564 Predicted integral membrane protein [Function unknown]; Region: COG0392 134676008565 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 134676008566 active site 134676008567 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 134676008568 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 134676008569 Peptidase family M28; Region: Peptidase_M28; pfam04389 134676008570 metal binding site [ion binding]; metal-binding site 134676008571 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 134676008572 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 134676008573 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 134676008574 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676008575 metal binding site [ion binding]; metal-binding site 134676008576 active site 134676008577 I-site; other site 134676008578 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 134676008579 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 134676008580 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 134676008581 nudix motif; other site 134676008582 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 134676008583 Catalytic domain of Protein Kinases; Region: PKc; cd00180 134676008584 active site 134676008585 ATP binding site [chemical binding]; other site 134676008586 substrate binding site [chemical binding]; other site 134676008587 activation loop (A-loop); other site 134676008588 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 134676008589 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 134676008590 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 134676008591 active site 134676008592 catalytic triad [active] 134676008593 oxyanion hole [active] 134676008594 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 134676008595 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 134676008596 putative sugar binding sites [chemical binding]; other site 134676008597 Q-X-W motif; other site 134676008598 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 134676008599 binding surface 134676008600 TPR motif; other site 134676008601 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 134676008602 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 134676008603 CHAT domain; Region: CHAT; pfam12770 134676008604 AAA ATPase domain; Region: AAA_16; pfam13191 134676008605 Tetratricopeptide repeat; Region: TPR_12; pfam13424 134676008606 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 134676008607 binding surface 134676008608 TPR motif; other site 134676008609 Tetratricopeptide repeat; Region: TPR_12; pfam13424 134676008610 Tetratricopeptide repeat; Region: TPR_12; pfam13424 134676008611 Tetratricopeptide repeat; Region: TPR_12; pfam13424 134676008612 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 134676008613 binding surface 134676008614 TPR motif; other site 134676008615 Tetratricopeptide repeat; Region: TPR_12; pfam13424 134676008616 MoxR-like ATPases [General function prediction only]; Region: COG0714 134676008617 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 134676008618 Walker A motif; other site 134676008619 ATP binding site [chemical binding]; other site 134676008620 Walker B motif; other site 134676008621 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 134676008622 Astacin (Peptidase family M12A); Region: Astacin; pfam01400 134676008623 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 134676008624 active site 134676008625 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 134676008626 CheB methylesterase; Region: CheB_methylest; pfam01339 134676008627 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 134676008628 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 134676008629 dimerization interface [polypeptide binding]; other site 134676008630 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 134676008631 dimer interface [polypeptide binding]; other site 134676008632 phosphorylation site [posttranslational modification] 134676008633 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676008634 ATP binding site [chemical binding]; other site 134676008635 G-X-G motif; other site 134676008636 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 134676008637 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676008638 active site 134676008639 phosphorylation site [posttranslational modification] 134676008640 intermolecular recognition site; other site 134676008641 dimerization interface [polypeptide binding]; other site 134676008642 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 134676008643 DNA binding site [nucleotide binding] 134676008644 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 134676008645 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 134676008646 Zn binding site [ion binding]; other site 134676008647 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 134676008648 Domain of unknown function (DUF4386); Region: DUF4386; pfam14329 134676008649 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 134676008650 GAF domain; Region: GAF; pfam01590 134676008651 GAF domain; Region: GAF; cl17456 134676008652 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 134676008653 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 134676008654 Resolvase, N terminal domain; Region: Resolvase; pfam00239 134676008655 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 134676008656 catalytic residues [active] 134676008657 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 134676008658 DNA-binding interface [nucleotide binding]; DNA binding site 134676008659 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 134676008660 Histidine kinase; Region: HisKA_3; pfam07730 134676008661 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 134676008662 putative substrate translocation pore; other site 134676008663 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 134676008664 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 134676008665 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 134676008666 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 134676008667 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 134676008668 putative dimer interface [polypeptide binding]; other site 134676008669 PAS fold; Region: PAS_4; pfam08448 134676008670 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 134676008671 GAF domain; Region: GAF; pfam01590 134676008672 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 134676008673 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 134676008674 Helix-turn-helix domain; Region: HTH_18; pfam12833 134676008675 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 134676008676 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 134676008677 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 134676008678 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 134676008679 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 134676008680 active site 134676008681 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 134676008682 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 134676008683 PAS domain; Region: PAS_9; pfam13426 134676008684 PAS domain; Region: PAS_9; pfam13426 134676008685 GAF domain; Region: GAF_3; pfam13492 134676008686 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 134676008687 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 134676008688 dimer interface [polypeptide binding]; other site 134676008689 phosphorylation site [posttranslational modification] 134676008690 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676008691 ATP binding site [chemical binding]; other site 134676008692 Mg2+ binding site [ion binding]; other site 134676008693 G-X-G motif; other site 134676008694 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 134676008695 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 134676008696 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 134676008697 acyl-activating enzyme (AAE) consensus motif; other site 134676008698 AMP binding site [chemical binding]; other site 134676008699 active site 134676008700 CoA binding site [chemical binding]; other site 134676008701 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 134676008702 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 134676008703 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 134676008704 putative trimer interface [polypeptide binding]; other site 134676008705 putative CoA binding site [chemical binding]; other site 134676008706 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 134676008707 Zn binding site [ion binding]; other site 134676008708 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 134676008709 Glycosyl hydrolase family 43; Region: GH43_4; cd08983 134676008710 active site 134676008711 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 134676008712 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 134676008713 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 134676008714 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 134676008715 active site 134676008716 substrate binding sites [chemical binding]; other site 134676008717 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cd00110 134676008718 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cl15820 134676008719 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 134676008720 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 134676008721 putative sugar binding sites [chemical binding]; other site 134676008722 Q-X-W motif; other site 134676008723 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 134676008724 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 134676008725 RHS Repeat; Region: RHS_repeat; pfam05593 134676008726 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 134676008727 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 134676008728 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 134676008729 RHS Repeat; Region: RHS_repeat; pfam05593 134676008730 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 134676008731 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 134676008732 protein-splicing catalytic site; other site 134676008733 thioester formation/cholesterol transfer; other site 134676008734 Pretoxin HINT domain; Region: PT-HINT; pfam07591 134676008735 PAS domain S-box; Region: sensory_box; TIGR00229 134676008736 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 134676008737 putative active site [active] 134676008738 heme pocket [chemical binding]; other site 134676008739 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 134676008740 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676008741 metal binding site [ion binding]; metal-binding site 134676008742 active site 134676008743 I-site; other site 134676008744 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 134676008745 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 134676008746 putative active site [active] 134676008747 heme pocket [chemical binding]; other site 134676008748 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 134676008749 dimer interface [polypeptide binding]; other site 134676008750 phosphorylation site [posttranslational modification] 134676008751 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676008752 ATP binding site [chemical binding]; other site 134676008753 Mg2+ binding site [ion binding]; other site 134676008754 G-X-G motif; other site 134676008755 Response regulator receiver domain; Region: Response_reg; pfam00072 134676008756 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676008757 active site 134676008758 phosphorylation site [posttranslational modification] 134676008759 intermolecular recognition site; other site 134676008760 dimerization interface [polypeptide binding]; other site 134676008761 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 134676008762 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676008763 active site 134676008764 phosphorylation site [posttranslational modification] 134676008765 intermolecular recognition site; other site 134676008766 dimerization interface [polypeptide binding]; other site 134676008767 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 134676008768 putative binding surface; other site 134676008769 active site 134676008770 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 134676008771 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 134676008772 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 134676008773 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676008774 metal binding site [ion binding]; metal-binding site 134676008775 active site 134676008776 I-site; other site 134676008777 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 134676008778 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 134676008779 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 134676008780 putative active site [active] 134676008781 heme pocket [chemical binding]; other site 134676008782 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 134676008783 dimer interface [polypeptide binding]; other site 134676008784 phosphorylation site [posttranslational modification] 134676008785 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676008786 ATP binding site [chemical binding]; other site 134676008787 Mg2+ binding site [ion binding]; other site 134676008788 G-X-G motif; other site 134676008789 Response regulator receiver domain; Region: Response_reg; pfam00072 134676008790 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676008791 active site 134676008792 phosphorylation site [posttranslational modification] 134676008793 intermolecular recognition site; other site 134676008794 dimerization interface [polypeptide binding]; other site 134676008795 Response regulator receiver domain; Region: Response_reg; pfam00072 134676008796 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676008797 active site 134676008798 phosphorylation site [posttranslational modification] 134676008799 intermolecular recognition site; other site 134676008800 dimerization interface [polypeptide binding]; other site 134676008801 GAF domain; Region: GAF; pfam01590 134676008802 GAF domain; Region: GAF_2; pfam13185 134676008803 GAF domain; Region: GAF_2; pfam13185 134676008804 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 134676008805 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 134676008806 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 134676008807 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 134676008808 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 134676008809 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 134676008810 Phosphoesterase family; Region: Phosphoesterase; pfam04185 134676008811 Peptidase family M48; Region: Peptidase_M48; cl12018 134676008812 Penicillinase repressor; Region: Pencillinase_R; cl17580 134676008813 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 134676008814 Pyruvate formate lyase; Region: PFL; pfam02901 134676008815 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 134676008816 Ligand Binding Site [chemical binding]; other site 134676008817 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 134676008818 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 134676008819 NADH(P)-binding; Region: NAD_binding_10; pfam13460 134676008820 NAD(P) binding site [chemical binding]; other site 134676008821 active site 134676008822 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 134676008823 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 134676008824 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 134676008825 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 134676008826 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 134676008827 PAS domain; Region: PAS; smart00091 134676008828 putative active site [active] 134676008829 heme pocket [chemical binding]; other site 134676008830 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 134676008831 dimer interface [polypeptide binding]; other site 134676008832 phosphorylation site [posttranslational modification] 134676008833 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676008834 ATP binding site [chemical binding]; other site 134676008835 Mg2+ binding site [ion binding]; other site 134676008836 G-X-G motif; other site 134676008837 Response regulator receiver domain; Region: Response_reg; pfam00072 134676008838 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676008839 active site 134676008840 phosphorylation site [posttranslational modification] 134676008841 intermolecular recognition site; other site 134676008842 dimerization interface [polypeptide binding]; other site 134676008843 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 134676008844 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 134676008845 substrate binding pocket [chemical binding]; other site 134676008846 membrane-bound complex binding site; other site 134676008847 hinge residues; other site 134676008848 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 134676008849 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676008850 metal binding site [ion binding]; metal-binding site 134676008851 active site 134676008852 I-site; other site 134676008853 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 134676008854 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676008855 metal binding site [ion binding]; metal-binding site 134676008856 active site 134676008857 I-site; other site 134676008858 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 134676008859 putative lyase; Provisional; Region: PRK09687 134676008860 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 134676008861 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 134676008862 active site 134676008863 Clp amino terminal domain; Region: Clp_N; pfam02861 134676008864 DoxX-like family; Region: DoxX_2; pfam13564 134676008865 YCII-related domain; Region: YCII; cl00999 134676008866 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 134676008867 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 134676008868 DNA binding residues [nucleotide binding] 134676008869 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 134676008870 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676008871 metal binding site [ion binding]; metal-binding site 134676008872 active site 134676008873 I-site; other site 134676008874 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 134676008875 Catalytic domain of Protein Kinases; Region: PKc; cd00180 134676008876 active site 134676008877 ATP binding site [chemical binding]; other site 134676008878 substrate binding site [chemical binding]; other site 134676008879 activation loop (A-loop); other site 134676008880 AAA ATPase domain; Region: AAA_16; pfam13191 134676008881 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 134676008882 GAF domain; Region: GAF_3; pfam13492 134676008883 GAF domain; Region: GAF_2; pfam13185 134676008884 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 134676008885 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676008886 metal binding site [ion binding]; metal-binding site 134676008887 active site 134676008888 I-site; other site 134676008889 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 134676008890 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418 134676008891 active site 134676008892 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 134676008893 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676008894 metal binding site [ion binding]; metal-binding site 134676008895 active site 134676008896 I-site; other site 134676008897 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 134676008898 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 134676008899 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 134676008900 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 134676008901 active site 134676008902 homotetramer interface [polypeptide binding]; other site 134676008903 Domain of unknown function (DUF4360); Region: DUF4360; pfam14273 134676008904 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 134676008905 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 134676008906 dimer interface [polypeptide binding]; other site 134676008907 phosphorylation site [posttranslational modification] 134676008908 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676008909 ATP binding site [chemical binding]; other site 134676008910 Mg2+ binding site [ion binding]; other site 134676008911 G-X-G motif; other site 134676008912 Response regulator receiver domain; Region: Response_reg; pfam00072 134676008913 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676008914 active site 134676008915 phosphorylation site [posttranslational modification] 134676008916 intermolecular recognition site; other site 134676008917 dimerization interface [polypeptide binding]; other site 134676008918 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 134676008919 nucleotide binding site [chemical binding]; other site 134676008920 putative NEF/HSP70 interaction site [polypeptide binding]; other site 134676008921 SBD interface [polypeptide binding]; other site 134676008922 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 134676008923 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 134676008924 ATP binding site [chemical binding]; other site 134676008925 Mg2+ binding site [ion binding]; other site 134676008926 G-X-G motif; other site 134676008927 Response regulator receiver domain; Region: Response_reg; pfam00072 134676008928 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676008929 active site 134676008930 phosphorylation site [posttranslational modification] 134676008931 intermolecular recognition site; other site 134676008932 dimerization interface [polypeptide binding]; other site 134676008933 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 134676008934 GAF domain; Region: GAF; pfam01590 134676008935 PAS domain; Region: PAS_9; pfam13426 134676008936 GAF domain; Region: GAF; pfam01590 134676008937 GAF domain; Region: GAF_2; pfam13185 134676008938 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 134676008939 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 134676008940 dimer interface [polypeptide binding]; other site 134676008941 phosphorylation site [posttranslational modification] 134676008942 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676008943 ATP binding site [chemical binding]; other site 134676008944 Mg2+ binding site [ion binding]; other site 134676008945 G-X-G motif; other site 134676008946 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676008947 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 134676008948 metal binding site [ion binding]; metal-binding site 134676008949 active site 134676008950 I-site; other site 134676008951 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 134676008952 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676008953 active site 134676008954 phosphorylation site [posttranslational modification] 134676008955 intermolecular recognition site; other site 134676008956 dimerization interface [polypeptide binding]; other site 134676008957 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676008958 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 134676008959 active site 134676008960 phosphorylation site [posttranslational modification] 134676008961 intermolecular recognition site; other site 134676008962 dimerization interface [polypeptide binding]; other site 134676008963 Domain of unknown function (DUF305); Region: DUF305; pfam03713 134676008964 Domain of unknown function (DUF305); Region: DUF305; pfam03713 134676008965 Ricin-type beta-trefoil; Region: RICIN; smart00458 134676008966 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 134676008967 putative sugar binding sites [chemical binding]; other site 134676008968 Q-X-W motif; other site 134676008969 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 134676008970 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 134676008971 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 134676008972 putative sugar binding sites [chemical binding]; other site 134676008973 Q-X-W motif; other site 134676008974 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 134676008975 Putative Ig domain; Region: He_PIG; pfam05345 134676008976 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 134676008977 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 134676008978 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676008979 metal binding site [ion binding]; metal-binding site 134676008980 active site 134676008981 I-site; other site 134676008982 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 134676008983 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676008984 metal binding site [ion binding]; metal-binding site 134676008985 active site 134676008986 I-site; other site 134676008987 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 134676008988 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 134676008989 active site 134676008990 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 134676008991 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 134676008992 transposase/IS protein; Provisional; Region: PRK09183 134676008993 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 134676008994 Walker A motif; other site 134676008995 ATP binding site [chemical binding]; other site 134676008996 Walker B motif; other site 134676008997 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 134676008998 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 134676008999 DXD motif; other site 134676009000 GAF domain; Region: GAF; cl17456 134676009001 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 134676009002 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 134676009003 dimer interface [polypeptide binding]; other site 134676009004 phosphorylation site [posttranslational modification] 134676009005 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676009006 ATP binding site [chemical binding]; other site 134676009007 Mg2+ binding site [ion binding]; other site 134676009008 G-X-G motif; other site 134676009009 hypothetical protein; Provisional; Region: PRK06194 134676009010 classical (c) SDRs; Region: SDR_c; cd05233 134676009011 NAD(P) binding site [chemical binding]; other site 134676009012 active site 134676009013 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 134676009014 anti sigma factor interaction site; other site 134676009015 regulatory phosphorylation site [posttranslational modification]; other site 134676009016 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 134676009017 GAF domain; Region: GAF_2; pfam13185 134676009018 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 134676009019 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 134676009020 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 134676009021 dimer interface [polypeptide binding]; other site 134676009022 putative CheW interface [polypeptide binding]; other site 134676009023 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 134676009024 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 134676009025 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 134676009026 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676009027 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 134676009028 PRC-barrel domain; Region: PRC; pfam05239 134676009029 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 134676009030 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 134676009031 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 134676009032 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676009033 metal binding site [ion binding]; metal-binding site 134676009034 active site 134676009035 I-site; other site 134676009036 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 134676009037 hypothetical protein; Provisional; Region: PRK08201 134676009038 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 134676009039 metal binding site [ion binding]; metal-binding site 134676009040 GAF domain; Region: GAF; pfam01590 134676009041 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 134676009042 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 134676009043 dimer interface [polypeptide binding]; other site 134676009044 phosphorylation site [posttranslational modification] 134676009045 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676009046 ATP binding site [chemical binding]; other site 134676009047 Mg2+ binding site [ion binding]; other site 134676009048 G-X-G motif; other site 134676009049 PAS domain; Region: PAS; smart00091 134676009050 PAS domain; Region: PAS_9; pfam13426 134676009051 putative active site [active] 134676009052 PAS fold; Region: PAS; pfam00989 134676009053 PAS domain; Region: PAS; smart00091 134676009054 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 134676009055 GAF domain; Region: GAF_3; pfam13492 134676009056 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 134676009057 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 134676009058 dimer interface [polypeptide binding]; other site 134676009059 phosphorylation site [posttranslational modification] 134676009060 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676009061 ATP binding site [chemical binding]; other site 134676009062 Mg2+ binding site [ion binding]; other site 134676009063 G-X-G motif; other site 134676009064 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 134676009065 Fasciclin domain; Region: Fasciclin; pfam02469 134676009066 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 134676009067 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 134676009068 Moco binding site; other site 134676009069 metal coordination site [ion binding]; other site 134676009070 dimerization interface [polypeptide binding]; other site 134676009071 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 134676009072 Catalytic domain of Protein Kinases; Region: PKc; cd00180 134676009073 active site 134676009074 ATP binding site [chemical binding]; other site 134676009075 substrate binding site [chemical binding]; other site 134676009076 activation loop (A-loop); other site 134676009077 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 134676009078 active site 134676009079 putative catalytic site [active] 134676009080 circadian clock protein KaiC; Reviewed; Region: PRK09302 134676009081 recA bacterial DNA recombination protein; Region: RecA; cl17211 134676009082 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 134676009083 Walker A motif; other site 134676009084 ATP binding site [chemical binding]; other site 134676009085 Walker B motif; other site 134676009086 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 134676009087 Walker A motif; other site 134676009088 ATP binding site [chemical binding]; other site 134676009089 Walker B motif; other site 134676009090 Response regulator receiver domain; Region: Response_reg; pfam00072 134676009091 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676009092 active site 134676009093 phosphorylation site [posttranslational modification] 134676009094 intermolecular recognition site; other site 134676009095 dimerization interface [polypeptide binding]; other site 134676009096 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 134676009097 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 134676009098 putative DNA binding site [nucleotide binding]; other site 134676009099 putative Zn2+ binding site [ion binding]; other site 134676009100 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 134676009101 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 134676009102 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 134676009103 microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th, Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212 134676009104 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 134676009105 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 134676009106 Walker A motif; other site 134676009107 ATP binding site [chemical binding]; other site 134676009108 Walker B motif; other site 134676009109 Tetratricopeptide repeat; Region: TPR_12; pfam13424 134676009110 Tetratricopeptide repeat; Region: TPR_12; pfam13424 134676009111 Tetratricopeptide repeat; Region: TPR_12; pfam13424 134676009112 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 134676009113 PGAP1-like protein; Region: PGAP1; pfam07819 134676009114 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 134676009115 MarR family; Region: MarR; pfam01047 134676009116 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 134676009117 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 134676009118 Domain of unknown function (DUF397); Region: DUF397; pfam04149 134676009119 PrgI family protein; Region: PrgI; pfam12666 134676009120 AAA-like domain; Region: AAA_10; pfam12846 134676009121 Domain of unknown function DUF87; Region: DUF87; pfam01935 134676009122 AAA-like domain; Region: AAA_10; pfam12846 134676009123 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 134676009124 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 134676009125 Replication-relaxation; Region: Replic_Relax; pfam13814 134676009126 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 134676009127 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 134676009128 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 134676009129 NAD(P) binding site [chemical binding]; other site 134676009130 active site 134676009131 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 134676009132 Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947 134676009133 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 134676009134 nucleotide binding site [chemical binding]; other site 134676009135 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 134676009136 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 134676009137 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 134676009138 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676009139 metal binding site [ion binding]; metal-binding site 134676009140 active site 134676009141 I-site; other site 134676009142 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 134676009143 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 134676009144 DNA protecting protein DprA; Region: dprA; TIGR00732 134676009145 conserved repeat domain; Region: B_ant_repeat; TIGR01451 134676009146 CARDB; Region: CARDB; pfam07705 134676009147 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 134676009148 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 134676009149 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676009150 ATP binding site [chemical binding]; other site 134676009151 Mg2+ binding site [ion binding]; other site 134676009152 G-X-G motif; other site 134676009153 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 134676009154 GAF domain; Region: GAF; pfam01590 134676009155 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 134676009156 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 134676009157 putative active site [active] 134676009158 heme pocket [chemical binding]; other site 134676009159 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 134676009160 PAS domain; Region: PAS_9; pfam13426 134676009161 putative active site [active] 134676009162 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 134676009163 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676009164 metal binding site [ion binding]; metal-binding site 134676009165 active site 134676009166 I-site; other site 134676009167 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 134676009168 NB-ARC domain; Region: NB-ARC; pfam00931 134676009169 Tetratricopeptide repeat; Region: TPR_12; pfam13424 134676009170 Tetratricopeptide repeat; Region: TPR_12; pfam13424 134676009171 Tetratricopeptide repeat; Region: TPR_12; pfam13424 134676009172 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 134676009173 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 134676009174 active site 134676009175 HIGH motif; other site 134676009176 KMSKS motif; other site 134676009177 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 134676009178 tRNA binding surface [nucleotide binding]; other site 134676009179 anticodon binding site; other site 134676009180 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 134676009181 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 134676009182 dimer interface [polypeptide binding]; other site 134676009183 phosphorylation site [posttranslational modification] 134676009184 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676009185 ATP binding site [chemical binding]; other site 134676009186 Mg2+ binding site [ion binding]; other site 134676009187 G-X-G motif; other site 134676009188 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 134676009189 hydrophobic ligand binding site; other site 134676009190 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 134676009191 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 134676009192 dimer interface [polypeptide binding]; other site 134676009193 putative CheW interface [polypeptide binding]; other site 134676009194 Domain of unknown function (DUF1768); Region: DUF1768; pfam08719 134676009195 GAF domain; Region: GAF; pfam01590 134676009196 GAF domain; Region: GAF_2; pfam13185 134676009197 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 134676009198 PAS domain; Region: PAS_9; pfam13426 134676009199 putative active site [active] 134676009200 heme pocket [chemical binding]; other site 134676009201 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 134676009202 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 134676009203 dimer interface [polypeptide binding]; other site 134676009204 phosphorylation site [posttranslational modification] 134676009205 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676009206 ATP binding site [chemical binding]; other site 134676009207 Mg2+ binding site [ion binding]; other site 134676009208 G-X-G motif; other site 134676009209 CHASE3 domain; Region: CHASE3; pfam05227 134676009210 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 134676009211 dimer interface [polypeptide binding]; other site 134676009212 phosphorylation site [posttranslational modification] 134676009213 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676009214 ATP binding site [chemical binding]; other site 134676009215 Mg2+ binding site [ion binding]; other site 134676009216 G-X-G motif; other site 134676009217 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 134676009218 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676009219 active site 134676009220 phosphorylation site [posttranslational modification] 134676009221 intermolecular recognition site; other site 134676009222 dimerization interface [polypeptide binding]; other site 134676009223 Response regulator receiver domain; Region: Response_reg; pfam00072 134676009224 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676009225 active site 134676009226 phosphorylation site [posttranslational modification] 134676009227 intermolecular recognition site; other site 134676009228 dimerization interface [polypeptide binding]; other site 134676009229 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 134676009230 Hemerythrin-like domain; Region: Hr-like; cd12108 134676009231 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 134676009232 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 134676009233 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 134676009234 catalytic residue [active] 134676009235 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 134676009236 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 134676009237 DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; cl15861 134676009238 transcription termination factor Rho; Provisional; Region: PRK12678 134676009239 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 134676009240 Transposase; Region: HTH_Tnp_1; cl17663 134676009241 Integrase core domain; Region: rve; pfam00665 134676009242 Integrase core domain; Region: rve_3; cl15866 134676009243 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 134676009244 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676009245 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 134676009246 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 134676009247 NAD(P) binding site [chemical binding]; other site 134676009248 active site 134676009249 Domain of unknown function (DUF385); Region: DUF385; cl04387 134676009250 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 134676009251 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676009252 metal binding site [ion binding]; metal-binding site 134676009253 active site 134676009254 I-site; other site 134676009255 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 134676009256 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 134676009257 active site 134676009258 phosphorylation site [posttranslational modification] 134676009259 intermolecular recognition site; other site 134676009260 dimerization interface [polypeptide binding]; other site 134676009261 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 134676009262 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676009263 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 134676009264 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 134676009265 substrate binding site [chemical binding]; other site 134676009266 activation loop (A-loop); other site 134676009267 Predicted ATPase [General function prediction only]; Region: COG3899 134676009268 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 134676009269 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 134676009270 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 134676009271 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 134676009272 putative active site [active] 134676009273 heme pocket [chemical binding]; other site 134676009274 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 134676009275 dimer interface [polypeptide binding]; other site 134676009276 phosphorylation site [posttranslational modification] 134676009277 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676009278 ATP binding site [chemical binding]; other site 134676009279 Mg2+ binding site [ion binding]; other site 134676009280 G-X-G motif; other site 134676009281 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 134676009282 Ricin-type beta-trefoil lectin domain-like; Region: RicinB_lectin_2; pfam14200 134676009283 Ricin-type beta-trefoil; Region: RICIN; smart00458 134676009284 Ricin-type beta-trefoil lectin domain-like; Region: RicinB_lectin_2; pfam14200 134676009285 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 134676009286 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 134676009287 putative sugar binding sites [chemical binding]; other site 134676009288 Q-X-W motif; other site 134676009289 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 134676009290 Ricin-type beta-trefoil lectin domain-like; Region: RicinB_lectin_2; pfam14200 134676009291 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 134676009292 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676009293 metal binding site [ion binding]; metal-binding site 134676009294 active site 134676009295 I-site; other site 134676009296 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 134676009297 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 134676009298 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676009299 metal binding site [ion binding]; metal-binding site 134676009300 active site 134676009301 I-site; other site 134676009302 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 134676009303 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 134676009304 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 134676009305 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 134676009306 YCII-related domain; Region: YCII; cl00999 134676009307 CAAX protease self-immunity; Region: Abi; pfam02517 134676009308 Putative sensor; Region: Sensor; pfam13796 134676009309 Histidine kinase; Region: HisKA_3; pfam07730 134676009310 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 134676009311 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 134676009312 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676009313 active site 134676009314 phosphorylation site [posttranslational modification] 134676009315 intermolecular recognition site; other site 134676009316 dimerization interface [polypeptide binding]; other site 134676009317 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 134676009318 DNA binding residues [nucleotide binding] 134676009319 dimerization interface [polypeptide binding]; other site 134676009320 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 134676009321 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676009322 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 134676009323 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 134676009324 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 134676009325 FtsX-like permease family; Region: FtsX; pfam02687 134676009326 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 134676009327 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 134676009328 Walker A/P-loop; other site 134676009329 ATP binding site [chemical binding]; other site 134676009330 Q-loop/lid; other site 134676009331 ABC transporter signature motif; other site 134676009332 Walker B; other site 134676009333 D-loop; other site 134676009334 H-loop/switch region; other site 134676009335 Putative sensor; Region: Sensor; pfam13796 134676009336 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 134676009337 Histidine kinase; Region: HisKA_3; pfam07730 134676009338 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676009339 ATP binding site [chemical binding]; other site 134676009340 Mg2+ binding site [ion binding]; other site 134676009341 G-X-G motif; other site 134676009342 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 134676009343 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676009344 active site 134676009345 phosphorylation site [posttranslational modification] 134676009346 intermolecular recognition site; other site 134676009347 dimerization interface [polypeptide binding]; other site 134676009348 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 134676009349 DNA binding residues [nucleotide binding] 134676009350 dimerization interface [polypeptide binding]; other site 134676009351 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 134676009352 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676009353 metal binding site [ion binding]; metal-binding site 134676009354 active site 134676009355 I-site; other site 134676009356 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 134676009357 anti sigma factor interaction site; other site 134676009358 regulatory phosphorylation site [posttranslational modification]; other site 134676009359 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 134676009360 Domain of unknown function (DUF4262); Region: DUF4262; pfam14081 134676009361 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 134676009362 FAD binding domain; Region: FAD_binding_4; pfam01565 134676009363 Berberine and berberine like; Region: BBE; pfam08031 134676009364 Cupin domain; Region: Cupin_2; pfam07883 134676009365 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 134676009366 B12 binding site [chemical binding]; other site 134676009367 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 134676009368 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 134676009369 FeS/SAM binding site; other site 134676009370 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 134676009371 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 134676009372 active site 134676009373 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 134676009374 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 134676009375 active site 134676009376 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 134676009377 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 134676009378 Major Facilitator Superfamily; Region: MFS_1; pfam07690 134676009379 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 134676009380 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 134676009381 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 134676009382 tRNA synthetases class I (M); Region: tRNA-synt_1g; pfam09334 134676009383 active site 134676009384 nucleotide binding site [chemical binding]; other site 134676009385 HIGH motif; other site 134676009386 KMSKS motif; other site 134676009387 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 134676009388 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 134676009389 bacteriocin maturation radical SAM protein 1; Region: rSAM_ocin_1; TIGR03975 134676009390 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 134676009391 B12 binding site [chemical binding]; other site 134676009392 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 134676009393 FeS/SAM binding site; other site 134676009394 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 134676009395 AAA domain; Region: AAA_22; pfam13401 134676009396 Tetratricopeptide repeat; Region: TPR_12; pfam13424 134676009397 Tetratricopeptide repeat; Region: TPR_12; pfam13424 134676009398 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 134676009399 binding surface 134676009400 TPR motif; other site 134676009401 Tetratricopeptide repeat; Region: TPR_12; pfam13424 134676009402 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 134676009403 putative catalytic site [active] 134676009404 putative phosphate binding site [ion binding]; other site 134676009405 putative metal binding site [ion binding]; other site 134676009406 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 134676009407 Isochorismatase family; Region: Isochorismatase; pfam00857 134676009408 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 134676009409 catalytic triad [active] 134676009410 conserved cis-peptide bond; other site 134676009411 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 134676009412 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 134676009413 catalytic Zn binding site [ion binding]; other site 134676009414 NAD(P) binding site [chemical binding]; other site 134676009415 structural Zn binding site [ion binding]; other site 134676009416 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 134676009417 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 134676009418 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676009419 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 134676009420 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 134676009421 extended (e) SDRs; Region: SDR_e; cd08946 134676009422 active site 134676009423 substrate binding site [chemical binding]; other site 134676009424 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 134676009425 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 134676009426 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676009427 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 134676009428 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 134676009429 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 134676009430 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 134676009431 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676009432 metal binding site [ion binding]; metal-binding site 134676009433 active site 134676009434 I-site; other site 134676009435 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 134676009436 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 134676009437 DNA binding site [nucleotide binding] 134676009438 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 134676009439 AAA ATPase domain; Region: AAA_16; pfam13191 134676009440 Tetratricopeptide repeat; Region: TPR_12; pfam13424 134676009441 Tetratricopeptide repeat; Region: TPR_12; pfam13424 134676009442 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 134676009443 binding surface 134676009444 TPR motif; other site 134676009445 Tetratricopeptide repeat; Region: TPR_12; pfam13424 134676009446 TIR domain; Region: TIR_2; cl17458 134676009447 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 134676009448 structural tetrad; other site 134676009449 FOG: WD40 repeat [General function prediction only]; Region: COG2319 134676009450 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 134676009451 structural tetrad; other site 134676009452 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 134676009453 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 134676009454 active site 134676009455 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 134676009456 Coenzyme A binding pocket [chemical binding]; other site 134676009457 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 134676009458 NACHT domain; Region: NACHT; pfam05729 134676009459 Catalytic domain of Protein Kinases; Region: PKc; cd00180 134676009460 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 134676009461 active site 134676009462 ATP binding site [chemical binding]; other site 134676009463 substrate binding site [chemical binding]; other site 134676009464 activation loop (A-loop); other site 134676009465 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 134676009466 FOG: WD40 repeat [General function prediction only]; Region: COG2319 134676009467 structural tetrad; other site 134676009468 FOG: WD40 repeat [General function prediction only]; Region: COG2319 134676009469 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 134676009470 structural tetrad; other site 134676009471 Tetratricopeptide repeat; Region: TPR_12; pfam13424 134676009472 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 134676009473 binding surface 134676009474 TPR motif; other site 134676009475 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 134676009476 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 134676009477 binding surface 134676009478 TPR motif; other site 134676009479 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 134676009480 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 134676009481 binding surface 134676009482 TPR motif; other site 134676009483 Transcriptional regulators [Transcription]; Region: PurR; COG1609 134676009484 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 134676009485 ligand binding site [chemical binding]; other site 134676009486 dimerization interface [polypeptide binding]; other site 134676009487 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 134676009488 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 134676009489 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 134676009490 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 134676009491 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 134676009492 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 134676009493 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 134676009494 putative hydrophobic ligand binding site [chemical binding]; other site 134676009495 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 134676009496 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676009497 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 134676009498 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 134676009499 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 134676009500 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 134676009501 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 134676009502 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 134676009503 RHS Repeat; Region: RHS_repeat; cl11982 134676009504 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 134676009505 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 134676009506 RHS Repeat; Region: RHS_repeat; cl11982 134676009507 RHS Repeat; Region: RHS_repeat; cl11982 134676009508 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 134676009509 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 134676009510 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 134676009511 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 134676009512 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 134676009513 GAF domain; Region: GAF; pfam01590 134676009514 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 134676009515 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676009516 metal binding site [ion binding]; metal-binding site 134676009517 active site 134676009518 I-site; other site 134676009519 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 134676009520 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 134676009521 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 134676009522 dimer interface [polypeptide binding]; other site 134676009523 putative CheW interface [polypeptide binding]; other site 134676009524 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676009525 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 134676009526 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 134676009527 Esterase PHB depolymerase; Region: Esterase_phd; pfam10503 134676009528 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 134676009529 Transcriptional regulators [Transcription]; Region: PurR; COG1609 134676009530 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 134676009531 ligand binding site [chemical binding]; other site 134676009532 dimerization interface [polypeptide binding]; other site 134676009533 Transcriptional regulators [Transcription]; Region: MarR; COG1846 134676009534 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 134676009535 putative Zn2+ binding site [ion binding]; other site 134676009536 putative DNA binding site [nucleotide binding]; other site 134676009537 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 134676009538 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 134676009539 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 134676009540 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 134676009541 anti sigma factor interaction site; other site 134676009542 regulatory phosphorylation site [posttranslational modification]; other site 134676009543 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 134676009544 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 134676009545 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676009546 ATP binding site [chemical binding]; other site 134676009547 Mg2+ binding site [ion binding]; other site 134676009548 G-X-G motif; other site 134676009549 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 134676009550 MarR family; Region: MarR; pfam01047 134676009551 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 134676009552 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 134676009553 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 134676009554 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676009555 metal binding site [ion binding]; metal-binding site 134676009556 active site 134676009557 I-site; other site 134676009558 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 134676009559 active site 134676009560 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 134676009561 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 134676009562 putative sugar binding sites [chemical binding]; other site 134676009563 Q-X-W motif; other site 134676009564 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 134676009565 Acarbose Gene Cluster 134676009566 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 134676009567 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 134676009568 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 134676009569 active site 134676009570 catalytic site [active] 134676009571 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 134676009572 carbohydrate binding site [chemical binding]; other site 134676009573 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 134676009574 carbohydrate binding site [chemical binding]; other site 134676009575 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 134676009576 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 134676009577 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 134676009578 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 134676009579 Walker A/P-loop; other site 134676009580 ATP binding site [chemical binding]; other site 134676009581 Q-loop/lid; other site 134676009582 ABC transporter signature motif; other site 134676009583 Walker B; other site 134676009584 D-loop; other site 134676009585 H-loop/switch region; other site 134676009586 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 134676009587 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 134676009588 inhibitor-cofactor binding pocket; inhibition site 134676009589 pyridoxal 5'-phosphate binding site [chemical binding]; other site 134676009590 catalytic residue [active] 134676009591 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 134676009592 Glycogen synthase [Carbohydrate transport and metabolism]; Region: GlgA; COG0297 134676009593 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 134676009594 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 134676009595 glucose-1-phosphate adenylyltransferase; Region: glgC; TIGR02091 134676009596 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 134676009597 oligomer interface; other site 134676009598 ligand binding site; other site 134676009599 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 134676009600 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 134676009601 dimer interface [polypeptide binding]; other site 134676009602 ADP-ribose binding site [chemical binding]; other site 134676009603 active site 134676009604 nudix motif; other site 134676009605 metal binding site [ion binding]; metal-binding site 134676009606 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 134676009607 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 134676009608 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 134676009609 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 134676009610 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 134676009611 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 134676009612 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 134676009613 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 134676009614 substrate binding site [chemical binding]; other site 134676009615 ATP binding site [chemical binding]; other site 134676009616 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 134676009617 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 134676009618 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 134676009619 NAD(P) binding site [chemical binding]; other site 134676009620 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 134676009621 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 134676009622 NAD(P) binding site [chemical binding]; other site 134676009623 active site 134676009624 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 134676009625 2-epi-5-epi-valiolone synthase (EEVS); Region: EEVS; cd08199 134676009626 active site 134676009627 metal binding site [ion binding]; metal-binding site 134676009628 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 134676009629 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 134676009630 NAD binding site [chemical binding]; other site 134676009631 substrate binding site [chemical binding]; other site 134676009632 homodimer interface [polypeptide binding]; other site 134676009633 active site 134676009634 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 134676009635 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 134676009636 tetramer interface; other site 134676009637 substrate binding site; other site 134676009638 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 134676009639 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 134676009640 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 134676009641 active site 134676009642 catalytic site [active] 134676009643 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 134676009644 carbohydrate binding site [chemical binding]; other site 134676009645 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 134676009646 carbohydrate binding site [chemical binding]; other site 134676009647 Alpha amylase catalytic domain found in maltogenic amylases, cyclodextrin glycosyltransferase, and related proteins; Region: AmyAc_AmyMalt_CGTase_like; cd11320 134676009648 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 134676009649 Ca binding site [ion binding]; other site 134676009650 active site 134676009651 catalytic site [active] 134676009652 Aamy_C domain; Region: Aamy_C; smart00632 134676009653 IPT domain (domain D) of cyclodextrin glycosyltransferase (CGTase) and similar enzymes. These enzymes are involved in the enzymatic hydrolysis of alpha-1,4 linkages of starch polymers and belong to the glycosyl hydrolase family 13. Most consist of three...; Region: IPT_CGTD; cd00604 134676009654 Novamyl (also known as acarviose transferase, ATase, maltogenic alpha-amylase, glucan 1,4-alpha-maltohydrolase, and AcbD), C-terminal CBM20 (carbohydrate-binding module, family 20) domain. Novamyl has a five-domain structure similar to that of...; Region: CBM20_novamyl; cd05820 134676009655 starch binding site 2 [chemical binding]; other site 134676009656 starch binding site 1 [chemical binding]; other site 134676009657 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 134676009658 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 134676009659 dimer interface [polypeptide binding]; other site 134676009660 conserved gate region; other site 134676009661 putative PBP binding loops; other site 134676009662 ABC-ATPase subunit interface; other site 134676009663 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 134676009664 dimer interface [polypeptide binding]; other site 134676009665 conserved gate region; other site 134676009666 putative PBP binding loops; other site 134676009667 ABC-ATPase subunit interface; other site 134676009668 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 134676009669 Glycosyl hydrolase family 59; Region: Glyco_hydro_59; pfam02057 134676009670 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 134676009671 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 134676009672 putative sugar binding sites [chemical binding]; other site 134676009673 Q-X-W motif; other site 134676009674 SGNH_hydrolase subfamily, similar to Ruminococcus flavefaciens XynB. Most likely a secreted hydrolase with xylanase activity. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from...; Region: XynB_like; cd01833 134676009675 active site 134676009676 catalytic triad [active] 134676009677 oxyanion hole [active] 134676009678 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 134676009679 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 134676009680 putative sugar binding sites [chemical binding]; other site 134676009681 Q-X-W motif; other site 134676009682 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 134676009683 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 134676009684 NAD(P) binding site [chemical binding]; other site 134676009685 active site 134676009686 Predicted transcriptional regulators [Transcription]; Region: COG1733 134676009687 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 134676009688 Predicted amidohydrolase [General function prediction only]; Region: COG0388 134676009689 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 134676009690 active site 134676009691 catalytic triad [active] 134676009692 dimer interface [polypeptide binding]; other site 134676009693 Cadmium resistance transporter; Region: Cad; pfam03596 134676009694 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 134676009695 active site 134676009696 catalytic triad [active] 134676009697 oxyanion hole [active] 134676009698 hypothetical protein; Provisional; Region: PRK06922 134676009699 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 134676009700 putative active site [active] 134676009701 putative metal binding residues [ion binding]; other site 134676009702 signature motif; other site 134676009703 putative triphosphate binding site [ion binding]; other site 134676009704 dimer interface [polypeptide binding]; other site 134676009705 MASE1; Region: MASE1; cl17823 134676009706 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 134676009707 PAS domain; Region: PAS; smart00091 134676009708 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 134676009709 dimer interface [polypeptide binding]; other site 134676009710 phosphorylation site [posttranslational modification] 134676009711 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676009712 ATP binding site [chemical binding]; other site 134676009713 Mg2+ binding site [ion binding]; other site 134676009714 G-X-G motif; other site 134676009715 Cupin domain; Region: Cupin_2; cl17218 134676009716 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 134676009717 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 134676009718 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 134676009719 NAD(P) binding site [chemical binding]; other site 134676009720 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 134676009721 dimerization interface [polypeptide binding]; other site 134676009722 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 134676009723 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 134676009724 dimerization interface [polypeptide binding]; other site 134676009725 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 134676009726 dimerization interface [polypeptide binding]; other site 134676009727 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 134676009728 dimerization interface [polypeptide binding]; other site 134676009729 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 134676009730 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 134676009731 dimerization interface [polypeptide binding]; other site 134676009732 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 134676009733 dimerization interface [polypeptide binding]; other site 134676009734 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 134676009735 dimerization interface [polypeptide binding]; other site 134676009736 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 134676009737 dimerization interface [polypeptide binding]; other site 134676009738 GAF domain; Region: GAF_2; pfam13185 134676009739 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 134676009740 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 134676009741 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676009742 ATP binding site [chemical binding]; other site 134676009743 Mg2+ binding site [ion binding]; other site 134676009744 G-X-G motif; other site 134676009745 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 134676009746 active site 134676009747 phosphorylation site [posttranslational modification] 134676009748 intermolecular recognition site; other site 134676009749 dimerization interface [polypeptide binding]; other site 134676009750 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 134676009751 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676009752 active site 134676009753 phosphorylation site [posttranslational modification] 134676009754 intermolecular recognition site; other site 134676009755 dimerization interface [polypeptide binding]; other site 134676009756 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 134676009757 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 134676009758 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 134676009759 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 134676009760 DNA binding residues [nucleotide binding] 134676009761 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 134676009762 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 134676009763 dimer interface [polypeptide binding]; other site 134676009764 putative CheW interface [polypeptide binding]; other site 134676009765 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 134676009766 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 134676009767 ligand binding site [chemical binding]; other site 134676009768 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 134676009769 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 134676009770 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 134676009771 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 134676009772 metal-binding site [ion binding] 134676009773 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 134676009774 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 134676009775 metal-binding site [ion binding] 134676009776 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 134676009777 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 134676009778 dimerization interface [polypeptide binding]; other site 134676009779 putative DNA binding site [nucleotide binding]; other site 134676009780 putative Zn2+ binding site [ion binding]; other site 134676009781 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 134676009782 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 134676009783 Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563 134676009784 active site triad [active] 134676009785 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 134676009786 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 134676009787 Walker A/P-loop; other site 134676009788 ATP binding site [chemical binding]; other site 134676009789 Q-loop/lid; other site 134676009790 ABC transporter signature motif; other site 134676009791 Walker B; other site 134676009792 D-loop; other site 134676009793 H-loop/switch region; other site 134676009794 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 134676009795 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 134676009796 active site 134676009797 catalytic site [active] 134676009798 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 134676009799 Starch binding domain; Region: CBM_2; smart01065 134676009800 starch-binding site 2 [chemical binding]; other site 134676009801 starch-binding site 1 [chemical binding]; other site 134676009802 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12902 134676009803 Tetratricopeptide repeat; Region: TPR_12; pfam13424 134676009804 Tetratricopeptide repeat; Region: TPR_12; pfam13424 134676009805 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 134676009806 binding surface 134676009807 TPR motif; other site 134676009808 Tetratricopeptide repeat; Region: TPR_12; pfam13424 134676009809 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 134676009810 binding surface 134676009811 TPR motif; other site 134676009812 Tetratricopeptide repeat; Region: TPR_12; pfam13424 134676009813 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 134676009814 binding surface 134676009815 TPR motif; other site 134676009816 Tetratricopeptide repeat; Region: TPR_12; pfam13424 134676009817 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 134676009818 DNA-binding site [nucleotide binding]; DNA binding site 134676009819 FeoA domain; Region: FeoA; pfam04023 134676009820 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 134676009821 DNA-binding site [nucleotide binding]; DNA binding site 134676009822 RNA-binding motif; other site 134676009823 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 134676009824 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 134676009825 DNA binding residues [nucleotide binding] 134676009826 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 134676009827 active site 134676009828 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 134676009829 aromatic chitin/cellulose binding site residues [chemical binding]; other site 134676009830 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 134676009831 active site 134676009832 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 134676009833 aromatic chitin/cellulose binding site residues [chemical binding]; other site 134676009834 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 134676009835 DNA binding residues [nucleotide binding] 134676009836 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 134676009837 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 134676009838 Beta-lactamase; Region: Beta-lactamase; pfam00144 134676009839 TraB family; Region: TraB; cl12050 134676009840 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 134676009841 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676009842 active site 134676009843 phosphorylation site [posttranslational modification] 134676009844 intermolecular recognition site; other site 134676009845 dimerization interface [polypeptide binding]; other site 134676009846 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 134676009847 DNA binding site [nucleotide binding] 134676009848 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 134676009849 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 134676009850 dimer interface [polypeptide binding]; other site 134676009851 phosphorylation site [posttranslational modification] 134676009852 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676009853 ATP binding site [chemical binding]; other site 134676009854 Mg2+ binding site [ion binding]; other site 134676009855 G-X-G motif; other site 134676009856 MMPL family; Region: MMPL; pfam03176 134676009857 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 134676009858 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 134676009859 Strictosidine synthase; Region: Str_synth; pfam03088 134676009860 Strictosidine synthase; Region: Str_synth; pfam03088 134676009861 YcaO-like family; Region: YcaO; pfam02624 134676009862 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 134676009863 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 134676009864 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 134676009865 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 134676009866 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 134676009867 FMN binding site [chemical binding]; other site 134676009868 dimer interface [polypeptide binding]; other site 134676009869 YcaO-like family; Region: YcaO; pfam02624 134676009870 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 134676009871 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 134676009872 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 134676009873 SpaB C-terminal domain; Region: SpaB_C; pfam14028 134676009874 bacteriocin maturation radical SAM protein 1; Region: rSAM_ocin_1; TIGR03975 134676009875 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 134676009876 B12 binding site [chemical binding]; other site 134676009877 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 134676009878 FeS/SAM binding site; other site 134676009879 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 134676009880 Diacylglycerol kinase accessory domain; Region: DAGK_acc; cl02440 134676009881 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 134676009882 FAD binding domain; Region: FAD_binding_4; pfam01565 134676009883 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 134676009884 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676009885 glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK13369 134676009886 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cl15820 134676009887 Catalytic domain of Arabidopsis thaliana PI-PLC X domain-containing protein At5g67130 and its uncharacterized homologs; Region: PI-PLCc_At5g67130_like; cd08588 134676009888 putative active site [active] 134676009889 catalytic site [active] 134676009890 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 134676009891 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676009892 ATP binding site [chemical binding]; other site 134676009893 G-X-G motif; other site 134676009894 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 134676009895 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 134676009896 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 134676009897 pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14853 134676009898 Catalytic domain of Streptomyces antibioticus phosphatidylinositol-specific phospholipase C1-like proteins; Region: PI-PLCc_SaPLC1_like; cd08589 134676009899 putative active site [active] 134676009900 catalytic site [active] 134676009901 putative metal binding site [ion binding]; other site 134676009902 Glycosyl hydrolase family 43; Region: GH43_ABN_2; cd08999 134676009903 putative substrate binding site [chemical binding]; other site 134676009904 active site 134676009905 Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081 134676009906 Ca binding site [ion binding]; other site 134676009907 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 134676009908 active site 134676009909 catalytic triad [active] 134676009910 oxyanion hole [active] 134676009911 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 134676009912 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 134676009913 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 134676009914 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676009915 metal binding site [ion binding]; metal-binding site 134676009916 active site 134676009917 I-site; other site 134676009918 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 134676009919 PAS fold; Region: PAS; pfam00989 134676009920 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 134676009921 putative active site [active] 134676009922 heme pocket [chemical binding]; other site 134676009923 PAS fold; Region: PAS_4; pfam08448 134676009924 PAS domain; Region: PAS_9; pfam13426 134676009925 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 134676009926 putative active site [active] 134676009927 heme pocket [chemical binding]; other site 134676009928 PAS domain; Region: PAS_9; pfam13426 134676009929 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 134676009930 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 134676009931 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 134676009932 glutamate carboxypeptidase; Reviewed; Region: PRK06133 134676009933 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 134676009934 metal binding site [ion binding]; metal-binding site 134676009935 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 134676009936 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 134676009937 Walker A/P-loop; other site 134676009938 ATP binding site [chemical binding]; other site 134676009939 Q-loop/lid; other site 134676009940 ABC transporter signature motif; other site 134676009941 Walker B; other site 134676009942 D-loop; other site 134676009943 H-loop/switch region; other site 134676009944 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 134676009945 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 134676009946 dimer interface [polypeptide binding]; other site 134676009947 conserved gate region; other site 134676009948 putative PBP binding loops; other site 134676009949 ABC-ATPase subunit interface; other site 134676009950 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 134676009951 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 134676009952 substrate binding pocket [chemical binding]; other site 134676009953 membrane-bound complex binding site; other site 134676009954 hinge residues; other site 134676009955 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 134676009956 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 134676009957 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 134676009958 putative active site [active] 134676009959 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 134676009960 proposed catalytic triad [active] 134676009961 active site nucleophile [active] 134676009962 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 134676009963 conserved cys residue [active] 134676009964 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 134676009965 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 134676009966 Ligand Binding Site [chemical binding]; other site 134676009967 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 134676009968 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676009969 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 134676009970 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676009971 metal binding site [ion binding]; metal-binding site 134676009972 active site 134676009973 I-site; other site 134676009974 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 134676009975 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 134676009976 Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915 134676009977 Predicted acetyltransferase [General function prediction only]; Region: COG3393 134676009978 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 134676009979 TOMM system kinase/cyclase fusion protein; Region: TOMM_kin_cyc; TIGR03903 134676009980 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 134676009981 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 134676009982 catalytic site [active] 134676009983 Flavoprotein; Region: Flavoprotein; pfam02441 134676009984 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 134676009985 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 134676009986 non-specific DNA binding site [nucleotide binding]; other site 134676009987 salt bridge; other site 134676009988 sequence-specific DNA binding site [nucleotide binding]; other site 134676009989 DivIVA domain; Region: DivI1A_domain; TIGR03544 134676009990 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 134676009991 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 134676009992 ABC transporter signature motif; other site 134676009993 Walker B; other site 134676009994 D-loop; other site 134676009995 H-loop/switch region; other site 134676009996 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 134676009997 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 134676009998 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 134676009999 FMN binding site [chemical binding]; other site 134676010000 active site 134676010001 substrate binding site [chemical binding]; other site 134676010002 catalytic residue [active] 134676010003 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 134676010004 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 134676010005 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 134676010006 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 134676010007 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 134676010008 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 134676010009 Walker A/P-loop; other site 134676010010 ATP binding site [chemical binding]; other site 134676010011 Q-loop/lid; other site 134676010012 ABC transporter signature motif; other site 134676010013 Walker B; other site 134676010014 D-loop; other site 134676010015 H-loop/switch region; other site 134676010016 ABC-2 type transporter; Region: ABC2_membrane; cl17235 134676010017 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 134676010018 Histidine kinase; Region: HisKA_3; pfam07730 134676010019 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 134676010020 ATP binding site [chemical binding]; other site 134676010021 Mg2+ binding site [ion binding]; other site 134676010022 G-X-G motif; other site 134676010023 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 134676010024 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676010025 active site 134676010026 phosphorylation site [posttranslational modification] 134676010027 intermolecular recognition site; other site 134676010028 dimerization interface [polypeptide binding]; other site 134676010029 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 134676010030 DNA binding residues [nucleotide binding] 134676010031 dimerization interface [polypeptide binding]; other site 134676010032 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 134676010033 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 134676010034 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 134676010035 FtsX-like permease family; Region: FtsX; pfam02687 134676010036 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 134676010037 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 134676010038 Walker A/P-loop; other site 134676010039 ATP binding site [chemical binding]; other site 134676010040 Q-loop/lid; other site 134676010041 ABC transporter signature motif; other site 134676010042 Walker B; other site 134676010043 D-loop; other site 134676010044 H-loop/switch region; other site 134676010045 Predicted transcriptional regulators [Transcription]; Region: COG1695 134676010046 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 134676010047 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 134676010048 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 134676010049 nudix motif; other site 134676010050 Domain of unknown function (DUF4265); Region: DUF4265; pfam14085 134676010051 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 134676010052 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676010053 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 134676010054 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 134676010055 Coenzyme A binding pocket [chemical binding]; other site 134676010056 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 134676010057 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 134676010058 catalytic site [active] 134676010059 TAP-like protein; Region: Abhydrolase_4; pfam08386 134676010060 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676010061 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 134676010062 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 134676010063 putative hydrophobic ligand binding site [chemical binding]; other site 134676010064 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 134676010065 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 134676010066 active site 134676010067 ATP binding site [chemical binding]; other site 134676010068 substrate binding site [chemical binding]; other site 134676010069 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 134676010070 DNA binding residues [nucleotide binding] 134676010071 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 134676010072 drug binding residues [chemical binding]; other site 134676010073 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 134676010074 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 134676010075 active site 134676010076 Restriction endonuclease; Region: Mrr_cat; pfam04471 134676010077 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 134676010078 Hyaluronidase protein (HylP); Region: Hyaluronidase_1; pfam07212 134676010079 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 134676010080 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 134676010081 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 134676010082 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cl00630 134676010083 putative active site [active] 134676010084 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 134676010085 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 134676010086 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 134676010087 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 134676010088 catalytic residue [active] 134676010089 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 134676010090 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676010091 active site 134676010092 phosphorylation site [posttranslational modification] 134676010093 intermolecular recognition site; other site 134676010094 dimerization interface [polypeptide binding]; other site 134676010095 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 134676010096 DNA binding residues [nucleotide binding] 134676010097 dimerization interface [polypeptide binding]; other site 134676010098 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 134676010099 Histidine kinase; Region: HisKA_3; pfam07730 134676010100 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676010101 ATP binding site [chemical binding]; other site 134676010102 Mg2+ binding site [ion binding]; other site 134676010103 G-X-G motif; other site 134676010104 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 134676010105 DNA binding site [nucleotide binding] 134676010106 active site 134676010107 Int/Topo IB signature motif; other site 134676010108 catalytic residues [active] 134676010109 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 134676010110 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 134676010111 ligand binding site [chemical binding]; other site 134676010112 dimerization interface [polypeptide binding]; other site 134676010113 Transcriptional regulators [Transcription]; Region: MarR; COG1846 134676010114 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 134676010115 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 134676010116 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 134676010117 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 134676010118 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676010119 metal binding site [ion binding]; metal-binding site 134676010120 active site 134676010121 I-site; other site 134676010122 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 134676010123 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 134676010124 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 134676010125 putative sugar binding sites [chemical binding]; other site 134676010126 Q-X-W motif; other site 134676010127 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 134676010128 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 134676010129 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 134676010130 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 134676010131 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 134676010132 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 134676010133 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 134676010134 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 134676010135 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 134676010136 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 134676010137 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 134676010138 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 134676010139 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 134676010140 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676010141 metal binding site [ion binding]; metal-binding site 134676010142 active site 134676010143 I-site; other site 134676010144 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 134676010145 Catalytic site [active] 134676010146 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 134676010147 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 134676010148 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 134676010149 Ricin-type beta-trefoil; Region: RICIN; smart00458 134676010150 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 134676010151 putative sugar binding sites [chemical binding]; other site 134676010152 Q-X-W motif; other site 134676010153 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 134676010154 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 134676010155 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 134676010156 putative substrate binding site [chemical binding]; other site 134676010157 putative ATP binding site [chemical binding]; other site 134676010158 dimerization interface [polypeptide binding]; other site 134676010159 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase); Region: GlcNAc_2-epim; pfam07221 134676010160 putative active cleft [active] 134676010161 Transcriptional regulators [Transcription]; Region: PurR; COG1609 134676010162 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 134676010163 ligand binding site [chemical binding]; other site 134676010164 dimerization interface [polypeptide binding]; other site 134676010165 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 134676010166 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 134676010167 nucleotide binding site [chemical binding]; other site 134676010168 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 134676010169 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 134676010170 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 134676010171 dimer interface [polypeptide binding]; other site 134676010172 conserved gate region; other site 134676010173 putative PBP binding loops; other site 134676010174 ABC-ATPase subunit interface; other site 134676010175 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 134676010176 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 134676010177 dimer interface [polypeptide binding]; other site 134676010178 conserved gate region; other site 134676010179 putative PBP binding loops; other site 134676010180 ABC-ATPase subunit interface; other site 134676010181 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 134676010182 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 134676010183 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 134676010184 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 134676010185 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 134676010186 Carbohydrate binding domain (family 11); Region: CBM_11; pfam03425 134676010187 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 134676010188 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 134676010189 Walker A/P-loop; other site 134676010190 ATP binding site [chemical binding]; other site 134676010191 Q-loop/lid; other site 134676010192 ABC transporter signature motif; other site 134676010193 Walker B; other site 134676010194 D-loop; other site 134676010195 H-loop/switch region; other site 134676010196 Esterase PHB depolymerase; Region: Esterase_phd; pfam10503 134676010197 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 134676010198 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 134676010199 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 134676010200 active site 134676010201 Predicted membrane protein [Function unknown]; Region: COG2259 134676010202 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 134676010203 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 134676010204 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 134676010205 Domain of unknown function (DUF397); Region: DUF397; pfam04149 134676010206 Domain of unknown function (DUF397); Region: DUF397; pfam04149 134676010207 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 134676010208 non-specific DNA binding site [nucleotide binding]; other site 134676010209 salt bridge; other site 134676010210 sequence-specific DNA binding site [nucleotide binding]; other site 134676010211 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 134676010212 putative substrate translocation pore; other site 134676010213 Transcriptional regulator [Transcription]; Region: LysR; COG0583 134676010214 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 134676010215 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 134676010216 dimerization interface [polypeptide binding]; other site 134676010217 Fasciclin domain; Region: Fasciclin; cl02663 134676010218 GAF domain; Region: GAF_3; pfam13492 134676010219 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 134676010220 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 134676010221 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 134676010222 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 134676010223 ATP binding site [chemical binding]; other site 134676010224 Mg2+ binding site [ion binding]; other site 134676010225 G-X-G motif; other site 134676010226 Methyltransferase domain; Region: Methyltransf_23; pfam13489 134676010227 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 134676010228 S-adenosylmethionine binding site [chemical binding]; other site 134676010229 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 134676010230 active site 134676010231 catalytic triad [active] 134676010232 oxyanion hole [active] 134676010233 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 134676010234 REJ domain; Region: REJ; pfam02010 134676010235 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 134676010236 putative catalytic site [active] 134676010237 putative metal binding site [ion binding]; other site 134676010238 putative phosphate binding site [ion binding]; other site 134676010239 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 134676010240 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 134676010241 NAD(P) binding site [chemical binding]; other site 134676010242 active site 134676010243 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 134676010244 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 134676010245 Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048 134676010246 IPT/TIG domain; Region: TIG; pfam01833 134676010247 MarR family; Region: MarR; pfam01047 134676010248 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 134676010249 hydrophobic ligand binding site; other site 134676010250 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 134676010251 glycerol kinase; Provisional; Region: glpK; PRK00047 134676010252 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 134676010253 nucleotide binding site [chemical binding]; other site 134676010254 Transcriptional regulator [Transcription]; Region: IclR; COG1414 134676010255 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 134676010256 Bacterial transcriptional regulator; Region: IclR; pfam01614 134676010257 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 134676010258 glycerol kinase; Provisional; Region: glpK; PRK00047 134676010259 nucleotide binding site [chemical binding]; other site 134676010260 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 134676010261 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 134676010262 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 134676010263 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 134676010264 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 134676010265 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 134676010266 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 134676010267 classical (c) SDRs; Region: SDR_c; cd05233 134676010268 NAD(P) binding site [chemical binding]; other site 134676010269 active site 134676010270 Domain of unknown function (DUF4265); Region: DUF4265; pfam14085 134676010271 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 134676010272 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676010273 metal binding site [ion binding]; metal-binding site 134676010274 active site 134676010275 I-site; other site 134676010276 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 134676010277 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 134676010278 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 134676010279 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 134676010280 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 134676010281 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 134676010282 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 134676010283 putative NADH binding site [chemical binding]; other site 134676010284 putative active site [active] 134676010285 nudix motif; other site 134676010286 putative metal binding site [ion binding]; other site 134676010287 tyramine oxidase; Provisional; Region: tynA; PRK11504 134676010288 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 134676010289 Domain of unknown function (DUF305); Region: DUF305; pfam03713 134676010290 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 134676010291 nudix motif; other site 134676010292 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 134676010293 Coenzyme A binding pocket [chemical binding]; other site 134676010294 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 134676010295 S-adenosylmethionine binding site [chemical binding]; other site 134676010296 hypothetical protein; Provisional; Region: PRK07588 134676010297 hypothetical protein; Provisional; Region: PRK07236 134676010298 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 134676010299 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676010300 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 134676010301 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 134676010302 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 134676010303 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 134676010304 NADH(P)-binding; Region: NAD_binding_10; pfam13460 134676010305 NAD(P) binding site [chemical binding]; other site 134676010306 active site 134676010307 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 134676010308 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676010309 metal binding site [ion binding]; metal-binding site 134676010310 active site 134676010311 I-site; other site 134676010312 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 134676010313 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 134676010314 conserved cys residue [active] 134676010315 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 134676010316 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 134676010317 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 134676010318 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 134676010319 substrate binding pocket [chemical binding]; other site 134676010320 chain length determination region; other site 134676010321 substrate-Mg2+ binding site; other site 134676010322 catalytic residues [active] 134676010323 aspartate-rich region 1; other site 134676010324 active site lid residues [active] 134676010325 aspartate-rich region 2; other site 134676010326 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 134676010327 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 134676010328 putative substrate translocation pore; other site 134676010329 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 134676010330 MarR family; Region: MarR_2; pfam12802 134676010331 amino acid transporter; Region: 2A0306; TIGR00909 134676010332 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 134676010333 Transcriptional regulator [Transcription]; Region: LysR; COG0583 134676010334 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 134676010335 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 134676010336 putative substrate binding pocket [chemical binding]; other site 134676010337 putative dimerization interface [polypeptide binding]; other site 134676010338 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 134676010339 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 134676010340 NADH(P)-binding; Region: NAD_binding_10; pfam13460 134676010341 NAD(P) binding site [chemical binding]; other site 134676010342 active site 134676010343 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 134676010344 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 134676010345 CoenzymeA binding site [chemical binding]; other site 134676010346 subunit interaction site [polypeptide binding]; other site 134676010347 PHB binding site; other site 134676010348 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 134676010349 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 134676010350 conserved cys residue [active] 134676010351 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 134676010352 MgtE intracellular N domain; Region: MgtE_N; cl15244 134676010353 Cupin superfamily protein; Region: Cupin_4; pfam08007 134676010354 Cupin-like domain; Region: Cupin_8; pfam13621 134676010355 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 134676010356 Cytochrome P450; Region: p450; cl12078 134676010357 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 134676010358 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 134676010359 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 134676010360 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 134676010361 Soluble P-type ATPase [General function prediction only]; Region: COG4087 134676010362 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 134676010363 RDD family; Region: RDD; pfam06271 134676010364 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 134676010365 Short C-terminal domain; Region: SHOCT; pfam09851 134676010366 Helix-turn-helix domain; Region: HTH_31; pfam13560 134676010367 FOG: WD40 repeat [General function prediction only]; Region: COG2319 134676010368 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 134676010369 structural tetrad; other site 134676010370 Protein of unknown function (DUF1269); Region: DUF1269; cl01978 134676010371 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 134676010372 Protein of unknown function (DUF1269); Region: DUF1269; cl01978 134676010373 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_1; cd11347 134676010374 active site 134676010375 catalytic site [active] 134676010376 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 134676010377 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 134676010378 DNA binding residues [nucleotide binding] 134676010379 dimerization interface [polypeptide binding]; other site 134676010380 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 134676010381 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 134676010382 DNA binding residues [nucleotide binding] 134676010383 dimerization interface [polypeptide binding]; other site 134676010384 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 134676010385 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 134676010386 putative active site [active] 134676010387 putative dimer interface [polypeptide binding]; other site 134676010388 Spore germination protein; Region: Spore_permease; cl17796 134676010389 arginine deiminase; Provisional; Region: PRK01388 134676010390 ornithine carbamoyltransferase; Validated; Region: PRK02102 134676010391 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 134676010392 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 134676010393 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 134676010394 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 134676010395 putative substrate binding site [chemical binding]; other site 134676010396 nucleotide binding site [chemical binding]; other site 134676010397 nucleotide binding site [chemical binding]; other site 134676010398 homodimer interface [polypeptide binding]; other site 134676010399 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 134676010400 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 134676010401 active site 134676010402 metal binding site [ion binding]; metal-binding site 134676010403 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 134676010404 Major Facilitator Superfamily; Region: MFS_1; pfam07690 134676010405 putative substrate translocation pore; other site 134676010406 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 134676010407 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 134676010408 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12407 134676010409 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 134676010410 Peptidase family M48; Region: Peptidase_M48; cl12018 134676010411 NACHT domain; Region: NACHT; pfam05729 134676010412 YcxB-like protein; Region: YcxB; pfam14317 134676010413 hypothetical protein; Provisional; Region: PRK07907 134676010414 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 134676010415 active site 134676010416 metal binding site [ion binding]; metal-binding site 134676010417 dimer interface [polypeptide binding]; other site 134676010418 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 134676010419 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 134676010420 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 134676010421 Major Facilitator Superfamily; Region: MFS_1; pfam07690 134676010422 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 134676010423 putative substrate translocation pore; other site 134676010424 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 134676010425 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 134676010426 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 134676010427 active site 134676010428 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676010429 metal binding site [ion binding]; metal-binding site 134676010430 active site 134676010431 I-site; other site 134676010432 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 134676010433 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 134676010434 putative substrate binding site [chemical binding]; other site 134676010435 putative ATP binding site [chemical binding]; other site 134676010436 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 134676010437 catalytic core [active] 134676010438 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 134676010439 YCII-related domain; Region: YCII; cl00999 134676010440 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 134676010441 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 134676010442 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 134676010443 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 134676010444 SnoaL-like domain; Region: SnoaL_2; pfam12680 134676010445 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 134676010446 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 134676010447 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 134676010448 DNA binding residues [nucleotide binding] 134676010449 putative dimer interface [polypeptide binding]; other site 134676010450 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 134676010451 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 134676010452 Domain of unknown function DUF20; Region: UPF0118; pfam01594 134676010453 Putative translation initiation inhibitor, yjgF family [Translation, ribosomal structure and biogenesis]; Region: TdcF; COG0251 134676010454 homotrimer interaction site [polypeptide binding]; other site 134676010455 putative active site [active] 134676010456 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 134676010457 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 134676010458 Transcriptional regulator [Transcription]; Region: LysR; COG0583 134676010459 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 134676010460 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 134676010461 putative dimerization interface [polypeptide binding]; other site 134676010462 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 134676010463 active site 134676010464 SnoaL-like domain; Region: SnoaL_2; pfam12680 134676010465 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 134676010466 putative DNA binding site [nucleotide binding]; other site 134676010467 dimerization interface [polypeptide binding]; other site 134676010468 putative Zn2+ binding site [ion binding]; other site 134676010469 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 134676010470 putative hydrophobic ligand binding site [chemical binding]; other site 134676010471 Response regulator receiver domain; Region: Response_reg; pfam00072 134676010472 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676010473 active site 134676010474 phosphorylation site [posttranslational modification] 134676010475 intermolecular recognition site; other site 134676010476 dimerization interface [polypeptide binding]; other site 134676010477 GAF domain; Region: GAF; pfam01590 134676010478 GAF domain; Region: GAF_2; pfam13185 134676010479 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 134676010480 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 134676010481 putative active site [active] 134676010482 heme pocket [chemical binding]; other site 134676010483 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 134676010484 dimer interface [polypeptide binding]; other site 134676010485 phosphorylation site [posttranslational modification] 134676010486 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676010487 ATP binding site [chemical binding]; other site 134676010488 Mg2+ binding site [ion binding]; other site 134676010489 G-X-G motif; other site 134676010490 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 134676010491 aromatic chitin/cellulose binding site residues [chemical binding]; other site 134676010492 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 134676010493 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 134676010494 putative active site [active] 134676010495 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 134676010496 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 134676010497 active site 134676010498 nucleophile elbow; other site 134676010499 HEAT repeats; Region: HEAT_2; pfam13646 134676010500 Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788 134676010501 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 134676010502 DNA binding residues [nucleotide binding] 134676010503 putative dimer interface [polypeptide binding]; other site 134676010504 HEAT repeats; Region: HEAT_2; pfam13646 134676010505 Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042 134676010506 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 134676010507 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 134676010508 Coenzyme A binding pocket [chemical binding]; other site 134676010509 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 134676010510 CoA binding domain; Region: CoA_binding_2; pfam13380 134676010511 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 134676010512 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676010513 metal binding site [ion binding]; metal-binding site 134676010514 active site 134676010515 I-site; other site 134676010516 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 134676010517 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 134676010518 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676010519 hypothetical protein; Provisional; Region: PRK07236 134676010520 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 134676010521 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 134676010522 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 134676010523 DNA binding residues [nucleotide binding] 134676010524 dimerization interface [polypeptide binding]; other site 134676010525 AAA ATPase domain; Region: AAA_16; pfam13191 134676010526 Predicted ATPase [General function prediction only]; Region: COG3899 134676010527 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 134676010528 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 134676010529 DNA binding residues [nucleotide binding] 134676010530 dimerization interface [polypeptide binding]; other site 134676010531 Phosphotransferase enzyme family; Region: APH; pfam01636 134676010532 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 134676010533 active site 134676010534 ATP binding site [chemical binding]; other site 134676010535 substrate binding site [chemical binding]; other site 134676010536 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 134676010537 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676010538 hypothetical protein; Validated; Region: PRK05868 134676010539 hypothetical protein; Provisional; Region: PRK07236 134676010540 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 134676010541 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 134676010542 PIN domain; Region: PIN; pfam01850 134676010543 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 134676010544 Catalytic domain of Protein Kinases; Region: PKc; cd00180 134676010545 active site 134676010546 ATP binding site [chemical binding]; other site 134676010547 substrate binding site [chemical binding]; other site 134676010548 activation loop (A-loop); other site 134676010549 succinic semialdehyde dehydrogenase; Region: PLN02278 134676010550 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 134676010551 NAD(P) binding site [chemical binding]; other site 134676010552 catalytic residues [active] 134676010553 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 134676010554 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 134676010555 inhibitor-cofactor binding pocket; inhibition site 134676010556 pyridoxal 5'-phosphate binding site [chemical binding]; other site 134676010557 catalytic residue [active] 134676010558 Transcriptional regulator [Transcription]; Region: LysR; COG0583 134676010559 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 134676010560 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 134676010561 dimerization interface [polypeptide binding]; other site 134676010562 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 134676010563 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 134676010564 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 134676010565 Walker A/P-loop; other site 134676010566 ATP binding site [chemical binding]; other site 134676010567 Q-loop/lid; other site 134676010568 ABC transporter signature motif; other site 134676010569 Walker B; other site 134676010570 D-loop; other site 134676010571 H-loop/switch region; other site 134676010572 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 134676010573 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 134676010574 homotrimer interaction site [polypeptide binding]; other site 134676010575 putative active site [active] 134676010576 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 134676010577 Leucine carboxyl methyltransferase; Region: LCM; cl01306 134676010578 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 134676010579 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 134676010580 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 134676010581 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 134676010582 Cellulose binding domain; Region: CBM_2; pfam00553 134676010583 Cellulose binding domain; Region: CBM_2; pfam00553 134676010584 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 134676010585 active site clefts [active] 134676010586 zinc binding site [ion binding]; other site 134676010587 dimer interface [polypeptide binding]; other site 134676010588 Transcriptional regulators [Transcription]; Region: MarR; COG1846 134676010589 MarR family; Region: MarR_2; pfam12802 134676010590 von Hippel-Landau (pVHL) tumor suppressor protein; Region: pVHL; cl03381 134676010591 pVHL-HIF-1alpha interaction [polypeptide binding]; other site 134676010592 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 134676010593 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 134676010594 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 134676010595 DXD motif; other site 134676010596 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 134676010597 HlyD family secretion protein; Region: HlyD_3; pfam13437 134676010598 Glycosyl hydrolase family 81; Region: Glyco_hydro_81; cl02310 134676010599 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 134676010600 NRPS 134676010601 Condensation domain; Region: Condensation; pfam00668 134676010602 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 134676010603 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 134676010604 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 134676010605 acyl-activating enzyme (AAE) consensus motif; other site 134676010606 AMP binding site [chemical binding]; other site 134676010607 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 134676010608 Condensation domain; Region: Condensation; pfam00668 134676010609 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 134676010610 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 134676010611 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 134676010612 acyl-activating enzyme (AAE) consensus motif; other site 134676010613 AMP binding site [chemical binding]; other site 134676010614 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 134676010615 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 134676010616 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 134676010617 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 134676010618 active site 134676010619 zinc binding site [ion binding]; other site 134676010620 AAA ATPase domain; Region: AAA_16; pfam13191 134676010621 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 134676010622 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 134676010623 DNA binding residues [nucleotide binding] 134676010624 MbtH-like protein; Region: MbtH; cl01279 134676010625 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 134676010626 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 134676010627 DNA binding residues [nucleotide binding] 134676010628 dimerization interface [polypeptide binding]; other site 134676010629 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 134676010630 active site 134676010631 calcium binding site 1 [ion binding]; other site 134676010632 Peptidase M35 domain of peptidyl-Lys metalloendopeptidases; Region: M35_peptidyl-Lys; cd11306 134676010633 active site 134676010634 Zn binding site [ion binding]; other site 134676010635 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 134676010636 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 134676010637 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 134676010638 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 134676010639 dimer interface [polypeptide binding]; other site 134676010640 pyridoxal 5'-phosphate binding site [chemical binding]; other site 134676010641 catalytic residue [active] 134676010642 Condensation domain; Region: Condensation; pfam00668 134676010643 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 134676010644 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 134676010645 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 134676010646 acyl-activating enzyme (AAE) consensus motif; other site 134676010647 AMP binding site [chemical binding]; other site 134676010648 Condensation domain; Region: Condensation; pfam00668 134676010649 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 134676010650 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 134676010651 acyl-activating enzyme (AAE) consensus motif; other site 134676010652 AMP binding site [chemical binding]; other site 134676010653 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 134676010654 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 134676010655 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 134676010656 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 134676010657 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 134676010658 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 134676010659 DinB superfamily; Region: DinB_2; pfam12867 134676010660 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 134676010661 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 134676010662 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 134676010663 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 134676010664 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 134676010665 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 134676010666 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 134676010667 acyl-activating enzyme (AAE) consensus motif; other site 134676010668 AMP binding site [chemical binding]; other site 134676010669 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 134676010670 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 134676010671 H+ Antiporter protein; Region: 2A0121; TIGR00900 134676010672 ornithine carbamoyltransferase; Provisional; Region: PRK00779 134676010673 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 134676010674 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 134676010675 diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264 134676010676 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 134676010677 inhibitor-cofactor binding pocket; inhibition site 134676010678 pyridoxal 5'-phosphate binding site [chemical binding]; other site 134676010679 catalytic residue [active] 134676010680 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 134676010681 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 134676010682 DNA binding residues [nucleotide binding] 134676010683 dimerization interface [polypeptide binding]; other site 134676010684 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 134676010685 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 134676010686 DNA binding residues [nucleotide binding] 134676010687 dimerization interface [polypeptide binding]; other site 134676010688 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 134676010689 Zn2+ binding site [ion binding]; other site 134676010690 Mg2+ binding site [ion binding]; other site 134676010691 Peptidase family M23; Region: Peptidase_M23; pfam01551 134676010692 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 134676010693 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 134676010694 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 134676010695 DNA binding residues [nucleotide binding] 134676010696 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 134676010697 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 134676010698 active site 134676010699 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 134676010700 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 134676010701 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 134676010702 Ligand binding site; other site 134676010703 Putative Catalytic site; other site 134676010704 DXD motif; other site 134676010705 Glyoxal oxidase N-terminus; Region: Glyoxal_oxid_N; pfam07250 134676010706 C-terminal Early set domain associated with the catalytic domain of galactose oxidase; Region: E_set_GO_C; cd02851 134676010707 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 134676010708 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 134676010709 catalytic residue [active] 134676010710 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 134676010711 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676010712 metal binding site [ion binding]; metal-binding site 134676010713 active site 134676010714 I-site; other site 134676010715 Uncharacterized conserved protein [Function unknown]; Region: COG3287 134676010716 FIST N domain; Region: FIST; pfam08495 134676010717 FIST C domain; Region: FIST_C; pfam10442 134676010718 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 134676010719 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 134676010720 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 134676010721 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 134676010722 Histidine kinase; Region: HisKA_3; pfam07730 134676010723 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676010724 ATP binding site [chemical binding]; other site 134676010725 Mg2+ binding site [ion binding]; other site 134676010726 G-X-G motif; other site 134676010727 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 134676010728 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676010729 active site 134676010730 phosphorylation site [posttranslational modification] 134676010731 intermolecular recognition site; other site 134676010732 dimerization interface [polypeptide binding]; other site 134676010733 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 134676010734 DNA binding residues [nucleotide binding] 134676010735 dimerization interface [polypeptide binding]; other site 134676010736 Transglycosylase; Region: Transgly; pfam00912 134676010737 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 134676010738 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 134676010739 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 134676010740 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 134676010741 NodB motif; other site 134676010742 active site 134676010743 catalytic site [active] 134676010744 metal binding site [ion binding]; metal-binding site 134676010745 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 134676010746 active site 134676010747 catalytic tetrad [active] 134676010748 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 134676010749 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 134676010750 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 134676010751 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 134676010752 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 134676010753 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 134676010754 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 134676010755 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 134676010756 Cysteine-rich domain; Region: CCG; pfam02754 134676010757 Cysteine-rich domain; Region: CCG; pfam02754 134676010758 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 134676010759 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 134676010760 C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor; Region: CtBP_dh; cd05299 134676010761 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 134676010762 ligand binding site [chemical binding]; other site 134676010763 NAD binding site [chemical binding]; other site 134676010764 catalytic site [active] 134676010765 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 134676010766 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 134676010767 Walker A/P-loop; other site 134676010768 ATP binding site [chemical binding]; other site 134676010769 Q-loop/lid; other site 134676010770 ABC transporter signature motif; other site 134676010771 Walker B; other site 134676010772 D-loop; other site 134676010773 H-loop/switch region; other site 134676010774 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 134676010775 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 134676010776 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 134676010777 TM-ABC transporter signature motif; other site 134676010778 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 134676010779 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 134676010780 TM-ABC transporter signature motif; other site 134676010781 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 134676010782 rhamnose ABC transporter, rhamnose-binding protein; Region: RhaS; TIGR02637 134676010783 Transcriptional regulators [Transcription]; Region: FadR; COG2186 134676010784 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 134676010785 DNA-binding site [nucleotide binding]; DNA binding site 134676010786 FCD domain; Region: FCD; pfam07729 134676010787 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 134676010788 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 134676010789 NAD(P) binding site [chemical binding]; other site 134676010790 Transcriptional regulators [Transcription]; Region: FadR; COG2186 134676010791 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 134676010792 DNA-binding site [nucleotide binding]; DNA binding site 134676010793 FCD domain; Region: FCD; pfam07729 134676010794 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 134676010795 classical (c) SDRs; Region: SDR_c; cd05233 134676010796 NAD(P) binding site [chemical binding]; other site 134676010797 active site 134676010798 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 134676010799 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 134676010800 dimer interface [polypeptide binding]; other site 134676010801 putative CheW interface [polypeptide binding]; other site 134676010802 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 134676010803 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676010804 metal binding site [ion binding]; metal-binding site 134676010805 active site 134676010806 I-site; other site 134676010807 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 134676010808 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676010809 metal binding site [ion binding]; metal-binding site 134676010810 active site 134676010811 I-site; other site 134676010812 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 134676010813 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676010814 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 134676010815 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 134676010816 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 134676010817 DNA-binding site [nucleotide binding]; DNA binding site 134676010818 FCD domain; Region: FCD; pfam07729 134676010819 short chain dehydrogenase; Provisional; Region: PRK08265 134676010820 classical (c) SDRs; Region: SDR_c; cd05233 134676010821 NAD(P) binding site [chemical binding]; other site 134676010822 active site 134676010823 DoxX; Region: DoxX; cl17842 134676010824 Transcriptional regulators [Transcription]; Region: FadR; COG2186 134676010825 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 134676010826 DNA-binding site [nucleotide binding]; DNA binding site 134676010827 FCD domain; Region: FCD; pfam07729 134676010828 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 134676010829 TAP-like protein; Region: Abhydrolase_4; pfam08386 134676010830 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 134676010831 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 134676010832 DNA binding residues [nucleotide binding] 134676010833 dimerization interface [polypeptide binding]; other site 134676010834 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 134676010835 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 134676010836 dimerization interface [polypeptide binding]; other site 134676010837 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 134676010838 dimer interface [polypeptide binding]; other site 134676010839 phosphorylation site [posttranslational modification] 134676010840 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676010841 ATP binding site [chemical binding]; other site 134676010842 Mg2+ binding site [ion binding]; other site 134676010843 G-X-G motif; other site 134676010844 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 134676010845 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676010846 active site 134676010847 phosphorylation site [posttranslational modification] 134676010848 intermolecular recognition site; other site 134676010849 dimerization interface [polypeptide binding]; other site 134676010850 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 134676010851 DNA binding site [nucleotide binding] 134676010852 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 134676010853 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 134676010854 Walker A/P-loop; other site 134676010855 ATP binding site [chemical binding]; other site 134676010856 Q-loop/lid; other site 134676010857 ABC transporter signature motif; other site 134676010858 Walker B; other site 134676010859 D-loop; other site 134676010860 H-loop/switch region; other site 134676010861 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 134676010862 FtsX-like permease family; Region: FtsX; pfam02687 134676010863 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 134676010864 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 134676010865 Copper type II ascorbate-dependent monooxygenase, C-terminal domain; Region: Cu2_monoox_C; pfam03712 134676010866 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 134676010867 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 134676010868 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 134676010869 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 134676010870 putative DNA binding site [nucleotide binding]; other site 134676010871 dimerization interface [polypeptide binding]; other site 134676010872 putative Zn2+ binding site [ion binding]; other site 134676010873 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 134676010874 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 134676010875 putative sugar binding sites [chemical binding]; other site 134676010876 Q-X-W motif; other site 134676010877 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 134676010878 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 134676010879 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 134676010880 anti sigma factor interaction site; other site 134676010881 regulatory phosphorylation site [posttranslational modification]; other site 134676010882 DDE superfamily endonuclease; Region: DDE_5; cl17874 134676010883 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 134676010884 S-adenosylmethionine binding site [chemical binding]; other site 134676010885 Phosphotransferase enzyme family; Region: APH; pfam01636 134676010886 Domain of unknown function (DUF4037); Region: DUF4037; pfam13228 134676010887 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 134676010888 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 134676010889 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 134676010890 DNA binding residues [nucleotide binding] 134676010891 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 134676010892 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 134676010893 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 134676010894 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 134676010895 dimerization interface [polypeptide binding]; other site 134676010896 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 134676010897 dimer interface [polypeptide binding]; other site 134676010898 putative CheW interface [polypeptide binding]; other site 134676010899 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 134676010900 GAF domain; Region: GAF; pfam01590 134676010901 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 134676010902 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 134676010903 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 134676010904 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 134676010905 NmrA-like family; Region: NmrA; pfam05368 134676010906 NAD(P) binding site [chemical binding]; other site 134676010907 active site 134676010908 Transcriptional regulator [Transcription]; Region: LysR; COG0583 134676010909 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 134676010910 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 134676010911 putative effector binding pocket; other site 134676010912 dimerization interface [polypeptide binding]; other site 134676010913 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 134676010914 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676010915 short chain dehydrogenase; Provisional; Region: PRK06197 134676010916 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 134676010917 putative NAD(P) binding site [chemical binding]; other site 134676010918 active site 134676010919 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 134676010920 putative active site [active] 134676010921 putative catalytic site [active] 134676010922 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 134676010923 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 134676010924 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676010925 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 134676010926 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676010927 active site 134676010928 phosphorylation site [posttranslational modification] 134676010929 intermolecular recognition site; other site 134676010930 dimerization interface [polypeptide binding]; other site 134676010931 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 134676010932 DNA binding residues [nucleotide binding] 134676010933 dimerization interface [polypeptide binding]; other site 134676010934 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 134676010935 Histidine kinase; Region: HisKA_3; pfam07730 134676010936 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 134676010937 ATP binding site [chemical binding]; other site 134676010938 Mg2+ binding site [ion binding]; other site 134676010939 G-X-G motif; other site 134676010940 AAA domain; Region: AAA_17; pfam13207 134676010941 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 134676010942 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 134676010943 YCII-related domain; Region: YCII; cl00999 134676010944 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 134676010945 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 134676010946 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 134676010947 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 134676010948 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 134676010949 Predicted transcriptional regulators [Transcription]; Region: COG1695 134676010950 Transcriptional regulator PadR-like family; Region: PadR; cl17335 134676010951 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 134676010952 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 134676010953 Catalytic site [active] 134676010954 Transcriptional regulator [Transcription]; Region: LysR; COG0583 134676010955 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 134676010956 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 134676010957 dimerization interface [polypeptide binding]; other site 134676010958 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 134676010959 classical (c) SDRs; Region: SDR_c; cd05233 134676010960 NAD(P) binding site [chemical binding]; other site 134676010961 active site 134676010962 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 134676010963 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 134676010964 active site 1 [active] 134676010965 dimer interface [polypeptide binding]; other site 134676010966 hexamer interface [polypeptide binding]; other site 134676010967 active site 2 [active] 134676010968 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 134676010969 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676010970 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 134676010971 active site residue [active] 134676010972 PAS domain; Region: PAS_9; pfam13426 134676010973 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 134676010974 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 134676010975 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676010976 ATP binding site [chemical binding]; other site 134676010977 Mg2+ binding site [ion binding]; other site 134676010978 G-X-G motif; other site 134676010979 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 134676010980 anti sigma factor interaction site; other site 134676010981 regulatory phosphorylation site [posttranslational modification]; other site 134676010982 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 134676010983 anti sigma factor interaction site; other site 134676010984 regulatory phosphorylation site [posttranslational modification]; other site 134676010985 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 134676010986 anti sigma factor interaction site; other site 134676010987 regulatory phosphorylation site [posttranslational modification]; other site 134676010988 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 134676010989 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 134676010990 catalytic residues [active] 134676010991 catalytic nucleophile [active] 134676010992 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 134676010993 DNA-binding interface [nucleotide binding]; DNA binding site 134676010994 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 134676010995 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 134676010996 NAD(P) binding site [chemical binding]; other site 134676010997 Uncharacterized conserved protein [Function unknown]; Region: COG4095 134676010998 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 134676010999 classical (c) SDRs; Region: SDR_c; cd05233 134676011000 NAD(P) binding site [chemical binding]; other site 134676011001 active site 134676011002 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 134676011003 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 134676011004 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 134676011005 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 134676011006 catalytic residues [active] 134676011007 catalytic nucleophile [active] 134676011008 Presynaptic Site I dimer interface [polypeptide binding]; other site 134676011009 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 134676011010 Synaptic Flat tetramer interface [polypeptide binding]; other site 134676011011 Synaptic Site I dimer interface [polypeptide binding]; other site 134676011012 DNA binding site [nucleotide binding] 134676011013 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 134676011014 Chromate transporter; Region: Chromate_transp; pfam02417 134676011015 Chromate resistance exported protein; Region: Chrome_Resist; pfam09828 134676011016 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 134676011017 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 134676011018 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 134676011019 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 134676011020 dimerization interface [polypeptide binding]; other site 134676011021 putative DNA binding site [nucleotide binding]; other site 134676011022 putative Zn2+ binding site [ion binding]; other site 134676011023 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 134676011024 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 134676011025 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 134676011026 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 134676011027 NAD(P) binding site [chemical binding]; other site 134676011028 active site 134676011029 Hemerythrin-like domain; Region: Hr-like; cd12108 134676011030 Fe binding site [ion binding]; other site 134676011031 Integral membrane protein TerC family; Region: TerC; cl10468 134676011032 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 134676011033 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676011034 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 134676011035 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 134676011036 dimer interface [polypeptide binding]; other site 134676011037 active site 134676011038 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 134676011039 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 134676011040 Zn binding site [ion binding]; other site 134676011041 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094 134676011042 Transcriptional regulator [Transcription]; Region: LysR; COG0583 134676011043 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 134676011044 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 134676011045 putative dimerization interface [polypeptide binding]; other site 134676011046 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 134676011047 Class I aldolases; Region: Aldolase_Class_I; cl17187 134676011048 catalytic residue [active] 134676011049 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 134676011050 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 134676011051 NAD(P) binding site [chemical binding]; other site 134676011052 active site 134676011053 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 134676011054 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 134676011055 motif II; other site 134676011056 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 134676011057 Clp amino terminal domain; Region: Clp_N; pfam02861 134676011058 Clp amino terminal domain; Region: Clp_N; pfam02861 134676011059 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 134676011060 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 134676011061 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 134676011062 Walker A/P-loop; other site 134676011063 ATP binding site [chemical binding]; other site 134676011064 Q-loop/lid; other site 134676011065 ABC transporter signature motif; other site 134676011066 Walker B; other site 134676011067 D-loop; other site 134676011068 H-loop/switch region; other site 134676011069 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 134676011070 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 134676011071 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 134676011072 Histidine kinase; Region: HisKA_3; pfam07730 134676011073 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 134676011074 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 134676011075 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676011076 active site 134676011077 phosphorylation site [posttranslational modification] 134676011078 intermolecular recognition site; other site 134676011079 dimerization interface [polypeptide binding]; other site 134676011080 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 134676011081 DNA binding residues [nucleotide binding] 134676011082 dimerization interface [polypeptide binding]; other site 134676011083 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 134676011084 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 134676011085 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 134676011086 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 134676011087 DNA binding residues [nucleotide binding] 134676011088 RibD C-terminal domain; Region: RibD_C; cl17279 134676011089 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 134676011090 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 134676011091 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 134676011092 pyridoxal 5'-phosphate binding site [chemical binding]; other site 134676011093 homodimer interface [polypeptide binding]; other site 134676011094 catalytic residue [active] 134676011095 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 134676011096 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 134676011097 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 134676011098 ABC transporter; Region: ABC_tran_2; pfam12848 134676011099 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 134676011100 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 134676011101 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 134676011102 active site 134676011103 Int/Topo IB signature motif; other site 134676011104 DNA binding site [nucleotide binding] 134676011105 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 134676011106 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 134676011107 nudix motif; other site 134676011108 replication termination (dif) site 134676011109 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 134676011110 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 134676011111 active site 134676011112 DNA binding site [nucleotide binding] 134676011113 Int/Topo IB signature motif; other site 134676011114 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 134676011115 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 134676011116 Methyltransferase domain; Region: Methyltransf_31; pfam13847 134676011117 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 134676011118 S-adenosylmethionine binding site [chemical binding]; other site 134676011119 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 134676011120 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 134676011121 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 134676011122 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 134676011123 NAD(P) binding site [chemical binding]; other site 134676011124 short chain dehydrogenase; Provisional; Region: PRK05854 134676011125 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 134676011126 NAD(P) binding site [chemical binding]; other site 134676011127 active site 134676011128 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 134676011129 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 134676011130 sequence-specific DNA binding site [nucleotide binding]; other site 134676011131 salt bridge; other site 134676011132 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 134676011133 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 134676011134 putative DNA binding site [nucleotide binding]; other site 134676011135 putative Zn2+ binding site [ion binding]; other site 134676011136 AsnC family; Region: AsnC_trans_reg; pfam01037 134676011137 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 134676011138 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 134676011139 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 134676011140 NAD(P) binding pocket [chemical binding]; other site 134676011141 Predicted transcriptional regulators [Transcription]; Region: COG1733 134676011142 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 134676011143 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 134676011144 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 134676011145 active site 134676011146 catalytic tetrad [active] 134676011147 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 134676011148 active site 134676011149 metal binding site [ion binding]; metal-binding site 134676011150 TM1410 hypothetical-related protein; Region: DUF297; pfam03537 134676011151 Protein of unknown function, DUF488; Region: DUF488; cl01246 134676011152 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 134676011153 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 134676011154 DNA binding residues [nucleotide binding] 134676011155 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 134676011156 Dynamin family; Region: Dynamin_N; pfam00350 134676011157 G1 box; other site 134676011158 GTP/Mg2+ binding site [chemical binding]; other site 134676011159 G2 box; other site 134676011160 Switch I region; other site 134676011161 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 134676011162 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 134676011163 Dynamin family; Region: Dynamin_N; pfam00350 134676011164 G1 box; other site 134676011165 Walker A/P-loop; other site 134676011166 GTP/Mg2+ binding site [chemical binding]; other site 134676011167 ATP binding site [chemical binding]; other site 134676011168 G2 box; other site 134676011169 Switch I region; other site 134676011170 G3 box; other site 134676011171 Switch II region; other site 134676011172 G4 box; other site 134676011173 G5 box; other site 134676011174 Vacuole effluxer Atg22 like; Region: ATG22; pfam11700 134676011175 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 134676011176 DNA-binding site [nucleotide binding]; DNA binding site 134676011177 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 134676011178 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 134676011179 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 134676011180 putative acyl-acceptor binding pocket; other site 134676011181 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 134676011182 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 134676011183 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 134676011184 active site 134676011185 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 134676011186 hypothetical protein; Provisional; Region: PRK07236 134676011187 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 134676011188 Methyltransferase domain; Region: Methyltransf_31; pfam13847 134676011189 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 134676011190 S-adenosylmethionine binding site [chemical binding]; other site 134676011191 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 134676011192 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 134676011193 NAD(P) binding site [chemical binding]; other site 134676011194 active site 134676011195 Domain of unknown function (DUF336); Region: DUF336; cl01249 134676011196 hypothetical protein; Provisional; Region: PRK10621 134676011197 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 134676011198 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 134676011199 putative catalytic site [active] 134676011200 putative metal binding site [ion binding]; other site 134676011201 putative phosphate binding site [ion binding]; other site 134676011202 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 134676011203 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 134676011204 MarR family; Region: MarR_2; cl17246 134676011205 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 134676011206 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 134676011207 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 134676011208 protein-splicing catalytic site; other site 134676011209 thioester formation/cholesterol transfer; other site 134676011210 Pretoxin HINT domain; Region: PT-HINT; pfam07591 134676011211 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 134676011212 active site 134676011213 ATP binding site [chemical binding]; other site 134676011214 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 134676011215 active site 134676011216 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 134676011217 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 134676011218 FAD binding domain; Region: FAD_binding_2; pfam00890 134676011219 IucA / IucC family; Region: IucA_IucC; pfam04183 134676011220 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 134676011221 IucA / IucC family; Region: IucA_IucC; pfam04183 134676011222 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 134676011223 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 134676011224 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 134676011225 catalytic residue [active] 134676011226 Erythromycin esterase; Region: Erythro_esteras; pfam05139 134676011227 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 134676011228 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 134676011229 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 134676011230 active site 134676011231 Uncharacterized conserved protein [Function unknown]; Region: COG3287 134676011232 FIST N domain; Region: FIST; pfam08495 134676011233 FIST C domain; Region: FIST_C; pfam10442 134676011234 GAF domain; Region: GAF; cl17456 134676011235 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 134676011236 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676011237 metal binding site [ion binding]; metal-binding site 134676011238 active site 134676011239 I-site; other site 134676011240 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 134676011241 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 134676011242 histidinol-phosphatase; Provisional; Region: PRK05588 134676011243 active site 134676011244 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 134676011245 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 134676011246 active site 134676011247 catalytic tetrad [active] 134676011248 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 134676011249 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 134676011250 Coenzyme A binding pocket [chemical binding]; other site 134676011251 RDD family; Region: RDD; pfam06271 134676011252 Integral membrane protein DUF95; Region: DUF95; pfam01944 134676011253 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 134676011254 Protein of unknown function DUF58; Region: DUF58; pfam01882 134676011255 MoxR-like ATPases [General function prediction only]; Region: COG0714 134676011256 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 134676011257 Walker A motif; other site 134676011258 ATP binding site [chemical binding]; other site 134676011259 Walker B motif; other site 134676011260 arginine finger; other site 134676011261 Protein of unknown function (DUF402); Region: DUF402; pfam04167 134676011262 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 134676011263 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 134676011264 salt bridge; other site 134676011265 non-specific DNA binding site [nucleotide binding]; other site 134676011266 sequence-specific DNA binding site [nucleotide binding]; other site 134676011267 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 134676011268 NAD(P) binding site [chemical binding]; other site 134676011269 active site 134676011270 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 134676011271 active site 134676011272 metal binding site [ion binding]; metal-binding site 134676011273 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 134676011274 nucleotide binding site/active site [active] 134676011275 HIT family signature motif; other site 134676011276 catalytic residue [active] 134676011277 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 134676011278 Active site serine [active] 134676011279 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 134676011280 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 134676011281 Domain of unknown function (DUF4259); Region: DUF4259; pfam14078 134676011282 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 134676011283 S-adenosylmethionine binding site [chemical binding]; other site 134676011284 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 134676011285 active site 134676011286 catalytic residues [active] 134676011287 metal binding site [ion binding]; metal-binding site 134676011288 AAA domain; Region: AAA_17; cl17253 134676011289 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 134676011290 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 134676011291 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 134676011292 DNA binding residues [nucleotide binding] 134676011293 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 134676011294 glycine dehydrogenase; Provisional; Region: PRK05367 134676011295 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 134676011296 tetramer interface [polypeptide binding]; other site 134676011297 pyridoxal 5'-phosphate binding site [chemical binding]; other site 134676011298 catalytic residue [active] 134676011299 Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG1003 134676011300 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 134676011301 catalytic residue [active] 134676011302 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 134676011303 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 134676011304 active site 134676011305 catalytic tetrad [active] 134676011306 Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417 134676011307 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 134676011308 Methyltransferase domain; Region: Methyltransf_31; pfam13847 134676011309 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 134676011310 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 134676011311 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 134676011312 non-specific DNA binding site [nucleotide binding]; other site 134676011313 salt bridge; other site 134676011314 sequence-specific DNA binding site [nucleotide binding]; other site 134676011315 Cupin domain; Region: Cupin_2; pfam07883 134676011316 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 134676011317 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 134676011318 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 134676011319 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676011320 enterobactin exporter EntS; Provisional; Region: PRK10489 134676011321 MarR family; Region: MarR_2; pfam12802 134676011322 Iron permease FTR1 family; Region: FTR1; pfam03239 134676011323 Imelysin; Region: Peptidase_M75; pfam09375 134676011324 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 134676011325 Penicillinase repressor; Region: Pencillinase_R; cl17580 134676011326 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 134676011327 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 134676011328 DEAD-like helicases superfamily; Region: DEXDc; smart00487 134676011329 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 134676011330 ATP binding site [chemical binding]; other site 134676011331 putative Mg++ binding site [ion binding]; other site 134676011332 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 134676011333 nucleotide binding region [chemical binding]; other site 134676011334 ATP-binding site [chemical binding]; other site 134676011335 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 134676011336 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 134676011337 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 134676011338 sequence-specific DNA binding site [nucleotide binding]; other site 134676011339 salt bridge; other site 134676011340 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 134676011341 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 134676011342 S-adenosylmethionine binding site [chemical binding]; other site 134676011343 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 134676011344 hypothetical protein; Provisional; Region: PRK06834 134676011345 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 134676011346 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 134676011347 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 134676011348 Walker A/P-loop; other site 134676011349 ATP binding site [chemical binding]; other site 134676011350 Q-loop/lid; other site 134676011351 ABC transporter signature motif; other site 134676011352 Walker B; other site 134676011353 D-loop; other site 134676011354 H-loop/switch region; other site 134676011355 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 134676011356 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 134676011357 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 134676011358 Phosphoesterase family; Region: Phosphoesterase; pfam04185 134676011359 Phosphoesterase family; Region: Phosphoesterase; pfam04185 134676011360 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 134676011361 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 134676011362 apolar tunnel; other site 134676011363 heme binding site [chemical binding]; other site 134676011364 dimerization interface [polypeptide binding]; other site 134676011365 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 134676011366 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 134676011367 motif II; other site 134676011368 hypothetical protein; Provisional; Region: PRK06847 134676011369 hypothetical protein; Provisional; Region: PRK07236 134676011370 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 134676011371 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676011372 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 134676011373 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 134676011374 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 134676011375 NAD binding site [chemical binding]; other site 134676011376 catalytic Zn binding site [ion binding]; other site 134676011377 structural Zn binding site [ion binding]; other site 134676011378 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 134676011379 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 134676011380 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 134676011381 Coenzyme A binding pocket [chemical binding]; other site 134676011382 deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026 134676011383 short chain dehydrogenase; Provisional; Region: PRK08251 134676011384 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 134676011385 NAD(P) binding site [chemical binding]; other site 134676011386 active site 134676011387 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 134676011388 catalytic core [active] 134676011389 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 134676011390 ABC1 family; Region: ABC1; cl17513 134676011391 Methyltransferase domain; Region: Methyltransf_11; pfam08241 134676011392 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 134676011393 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 134676011394 DNA-binding site [nucleotide binding]; DNA binding site 134676011395 RNA-binding motif; other site 134676011396 Haemolytic domain; Region: Haemolytic; cl00506 134676011397 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 134676011398 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 134676011399 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 134676011400 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 134676011401 DNA binding residues [nucleotide binding] 134676011402 dimerization interface [polypeptide binding]; other site 134676011403 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 134676011404 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 134676011405 DNA binding residues [nucleotide binding] 134676011406 Winged helix-turn helix; Region: HTH_29; pfam13551 134676011407 Homeodomain-like domain; Region: HTH_32; pfam13565 134676011408 DDE superfamily endonuclease; Region: DDE_3; pfam13358 134676011409 ChaP, an enzyme involved in the biosynthesis of the antitumor agent chartreusin (cha); and similar proteins; Region: ChaP_like; cd08351 134676011410 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 134676011411 metal binding site [ion binding]; metal-binding site 134676011412 YcxB-like protein; Region: YcxB; pfam14317 134676011413 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 134676011414 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 134676011415 Coenzyme A binding pocket [chemical binding]; other site 134676011416 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 134676011417 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 134676011418 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 134676011419 glycosyl hydrolase 64 family; Region: GH64-like; cd09214 134676011420 substrate binding pocket [chemical binding]; other site 134676011421 catalytic residues [active] 134676011422 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 134676011423 RibD C-terminal domain; Region: RibD_C; cl17279 134676011424 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 134676011425 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 134676011426 active site 134676011427 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 134676011428 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 134676011429 substrate binding pocket [chemical binding]; other site 134676011430 membrane-bound complex binding site; other site 134676011431 hinge residues; other site 134676011432 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 134676011433 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 134676011434 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 134676011435 dimer interface [polypeptide binding]; other site 134676011436 putative CheW interface [polypeptide binding]; other site 134676011437 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 134676011438 Domain of unknown function (DUF427); Region: DUF427; pfam04248 134676011439 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 134676011440 Leucine-rich repeats; other site 134676011441 Substrate binding site [chemical binding]; other site 134676011442 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 134676011443 classical (c) SDRs; Region: SDR_c; cd05233 134676011444 NAD(P) binding site [chemical binding]; other site 134676011445 active site 134676011446 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 134676011447 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 134676011448 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 134676011449 PemK-like protein; Region: PemK; pfam02452 134676011450 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 134676011451 homodimer interface [polypeptide binding]; other site 134676011452 active site 134676011453 TDP-binding site; other site 134676011454 acceptor substrate-binding pocket; other site 134676011455 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like; cd11354 134676011456 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 134676011457 active site 134676011458 catalytic site [active] 134676011459 Domain of unknown function (DUF1772); Region: DUF1772; pfam08592 134676011460 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676011461 WHG domain; Region: WHG; pfam13305 134676011462 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 134676011463 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 134676011464 substrate binding site [chemical binding]; other site 134676011465 oxyanion hole (OAH) forming residues; other site 134676011466 trimer interface [polypeptide binding]; other site 134676011467 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 134676011468 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102 134676011469 Predicted transcriptional regulators [Transcription]; Region: COG1695 134676011470 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 134676011471 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 134676011472 enoyl-CoA hydratase; Provisional; Region: PRK07509 134676011473 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 134676011474 substrate binding site [chemical binding]; other site 134676011475 oxyanion hole (OAH) forming residues; other site 134676011476 trimer interface [polypeptide binding]; other site 134676011477 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 134676011478 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 134676011479 active site 134676011480 FMN binding site [chemical binding]; other site 134676011481 2,4-decadienoyl-CoA binding site; other site 134676011482 catalytic residue [active] 134676011483 4Fe-4S cluster binding site [ion binding]; other site 134676011484 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 134676011485 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 134676011486 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 134676011487 putative sugar binding sites [chemical binding]; other site 134676011488 Q-X-W motif; other site 134676011489 Ricin-type beta-trefoil; Region: RICIN; smart00458 134676011490 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cl15820 134676011491 putative sugar binding sites [chemical binding]; other site 134676011492 Q-X-W motif; other site 134676011493 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 134676011494 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 134676011495 Putative Ig domain; Region: He_PIG; pfam05345 134676011496 Putative Ig domain; Region: He_PIG; pfam05345 134676011497 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 134676011498 TPP-binding site [chemical binding]; other site 134676011499 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 134676011500 PYR/PP interface [polypeptide binding]; other site 134676011501 dimer interface [polypeptide binding]; other site 134676011502 TPP binding site [chemical binding]; other site 134676011503 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 134676011504 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 134676011505 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 134676011506 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 134676011507 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 134676011508 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 134676011509 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 134676011510 MarR family; Region: MarR_2; cl17246 134676011511 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 134676011512 Interdomain contacts; other site 134676011513 Cellulose binding domain; Region: CBM_2; pfam00553 134676011514 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 134676011515 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 134676011516 subunit interaction site [polypeptide binding]; other site 134676011517 PHB binding site; other site 134676011518 CoenzymeA binding site [chemical binding]; other site 134676011519 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 134676011520 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 134676011521 Predicted transcriptional regulators [Transcription]; Region: COG1733 134676011522 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 134676011523 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 134676011524 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 134676011525 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676011526 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 134676011527 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 134676011528 potential catalytic triad [active] 134676011529 conserved cys residue [active] 134676011530 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 134676011531 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676011532 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 134676011533 Predicted permeases [General function prediction only]; Region: COG0679 134676011534 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 134676011535 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 134676011536 Walker A/P-loop; other site 134676011537 ATP binding site [chemical binding]; other site 134676011538 Q-loop/lid; other site 134676011539 ABC transporter signature motif; other site 134676011540 Walker B; other site 134676011541 D-loop; other site 134676011542 H-loop/switch region; other site 134676011543 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 134676011544 thiamine ABC transporter, ATP-binding protein; Region: thiQ; TIGR01277 134676011545 Walker A/P-loop; other site 134676011546 ATP binding site [chemical binding]; other site 134676011547 Q-loop/lid; other site 134676011548 ABC transporter signature motif; other site 134676011549 Walker B; other site 134676011550 D-loop; other site 134676011551 H-loop/switch region; other site 134676011552 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 134676011553 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 134676011554 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 134676011555 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 134676011556 active site 134676011557 ATP binding site [chemical binding]; other site 134676011558 Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147 134676011559 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cd04434 134676011560 active site 134676011561 zinc binding site [ion binding]; other site 134676011562 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 134676011563 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 134676011564 DNA binding residues [nucleotide binding] 134676011565 dimerization interface [polypeptide binding]; other site 134676011566 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 134676011567 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 134676011568 DNA binding residues [nucleotide binding] 134676011569 dimerization interface [polypeptide binding]; other site 134676011570 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 134676011571 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 134676011572 active site 134676011573 TIGR02679 family protein; Region: TIGR02679 134676011574 Protein of unknown function C-terminus (DUF2399); Region: DUF2399; pfam09664 134676011575 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 134676011576 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 134676011577 Winged helix-turn helix; Region: HTH_29; pfam13551 134676011578 Integrase core domain; Region: rve; pfam00665 134676011579 Integrase core domain; Region: rve_3; pfam13683 134676011580 TIGR02680 family protein; Region: TIGR02680 134676011581 Protein of unknown function (DUF2398); Region: DUF2398; cl09875 134676011582 Protein of unknown function (DUF2397); Region: DUF2397; pfam09660 134676011583 AMP-binding domain protein; Validated; Region: PRK08315 134676011584 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 134676011585 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 134676011586 acyl-activating enzyme (AAE) consensus motif; other site 134676011587 putative AMP binding site [chemical binding]; other site 134676011588 putative active site [active] 134676011589 putative CoA binding site [chemical binding]; other site 134676011590 RDD family; Region: RDD; pfam06271 134676011591 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 134676011592 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676011593 metal binding site [ion binding]; metal-binding site 134676011594 active site 134676011595 I-site; other site 134676011596 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 134676011597 Uncharacterized conserved protein [Function unknown]; Region: COG3595 134676011598 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 134676011599 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 134676011600 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 134676011601 Walker A/P-loop; other site 134676011602 ATP binding site [chemical binding]; other site 134676011603 Q-loop/lid; other site 134676011604 ABC transporter signature motif; other site 134676011605 Walker B; other site 134676011606 D-loop; other site 134676011607 H-loop/switch region; other site 134676011608 ABC-2 type transporter; Region: ABC2_membrane; cl17235 134676011609 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 134676011610 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 134676011611 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 134676011612 active site 134676011613 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 134676011614 potential frameshift: common BLAST hit: gi|312199046|ref|YP_004019107.1| integral membrane sensor signal transduction histidine kinase 134676011615 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 134676011616 Histidine kinase; Region: HisKA_3; pfam07730 134676011617 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676011618 ATP binding site [chemical binding]; other site 134676011619 Mg2+ binding site [ion binding]; other site 134676011620 G-X-G motif; other site 134676011621 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 134676011622 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676011623 active site 134676011624 phosphorylation site [posttranslational modification] 134676011625 intermolecular recognition site; other site 134676011626 dimerization interface [polypeptide binding]; other site 134676011627 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 134676011628 DNA binding residues [nucleotide binding] 134676011629 dimerization interface [polypeptide binding]; other site 134676011630 MarR family; Region: MarR; pfam01047 134676011631 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 134676011632 classical (c) SDRs; Region: SDR_c; cd05233 134676011633 NAD(P) binding site [chemical binding]; other site 134676011634 active site 134676011635 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 134676011636 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 134676011637 Predicted transcriptional regulators [Transcription]; Region: COG1733 134676011638 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 134676011639 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 134676011640 NADH(P)-binding; Region: NAD_binding_10; pfam13460 134676011641 NAD(P) binding site [chemical binding]; other site 134676011642 active site 134676011643 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 134676011644 6-hydroxycyclohex-1-ene-1-carboxyl-CoA dehydrogenase, N-benzyl-3-pyrrolidinol dehydrogenase, and other MDR family members; Region: hydroxyacyl_CoA_DH; cd08254 134676011645 putative NAD(P) binding site [chemical binding]; other site 134676011646 catalytic Zn binding site [ion binding]; other site 134676011647 structural Zn binding site [ion binding]; other site 134676011648 Protein of unknown function (DUF2283); Region: DUF2283; pfam10049 134676011649 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 134676011650 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 134676011651 coenzyme F420-dependent oxidoreductase, NP1902A family; Region: F420_NP1902A; TIGR04024 134676011652 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 134676011653 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 134676011654 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 134676011655 active site 134676011656 Transcriptional regulator; Region: Rrf2; pfam02082 134676011657 WYL domain; Region: WYL; pfam13280 134676011658 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 134676011659 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676011660 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 134676011661 active site 134676011662 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 134676011663 VanZ like family; Region: VanZ; pfam04892 134676011664 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 134676011665 CPxP motif; other site 134676011666 Domain of unknown function (DUF4279); Region: DUF4279; pfam14106 134676011667 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 134676011668 substrate binding site [chemical binding]; other site 134676011669 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 134676011670 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 134676011671 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 134676011672 DNA binding residues [nucleotide binding] 134676011673 drug binding residues [chemical binding]; other site 134676011674 dimer interface [polypeptide binding]; other site 134676011675 Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631 134676011676 active site 134676011677 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 134676011678 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 134676011679 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 134676011680 CGNR zinc finger; Region: zf-CGNR; pfam11706 134676011681 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 134676011682 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 134676011683 homodimer interface [polypeptide binding]; other site 134676011684 NAD binding pocket [chemical binding]; other site 134676011685 ATP binding pocket [chemical binding]; other site 134676011686 Mg binding site [ion binding]; other site 134676011687 active-site loop [active] 134676011688 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 134676011689 active site 134676011690 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 134676011691 putative hydrophobic ligand binding site [chemical binding]; other site 134676011692 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 134676011693 putative DNA binding site [nucleotide binding]; other site 134676011694 putative Zn2+ binding site [ion binding]; other site 134676011695 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 134676011696 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 134676011697 inhibitor site; inhibition site 134676011698 active site 134676011699 dimer interface [polypeptide binding]; other site 134676011700 catalytic residue [active] 134676011701 transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481 134676011702 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 134676011703 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 134676011704 pyridoxal 5'-phosphate binding site [chemical binding]; other site 134676011705 homodimer interface [polypeptide binding]; other site 134676011706 catalytic residue [active] 134676011707 PAS fold; Region: PAS; pfam00989 134676011708 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 134676011709 putative active site [active] 134676011710 heme pocket [chemical binding]; other site 134676011711 PAS domain S-box; Region: sensory_box; TIGR00229 134676011712 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 134676011713 putative active site [active] 134676011714 heme pocket [chemical binding]; other site 134676011715 GAF domain; Region: GAF_2; pfam13185 134676011716 GAF domain; Region: GAF_3; pfam13492 134676011717 PAS domain S-box; Region: sensory_box; TIGR00229 134676011718 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 134676011719 putative active site [active] 134676011720 heme pocket [chemical binding]; other site 134676011721 GAF domain; Region: GAF; pfam01590 134676011722 GAF domain; Region: GAF_2; pfam13185 134676011723 PAS domain S-box; Region: sensory_box; TIGR00229 134676011724 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 134676011725 putative active site [active] 134676011726 heme pocket [chemical binding]; other site 134676011727 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 134676011728 PAS domain; Region: PAS_9; pfam13426 134676011729 putative active site [active] 134676011730 heme pocket [chemical binding]; other site 134676011731 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 134676011732 PAS fold; Region: PAS_3; pfam08447 134676011733 putative active site [active] 134676011734 heme pocket [chemical binding]; other site 134676011735 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 134676011736 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 134676011737 dimer interface [polypeptide binding]; other site 134676011738 phosphorylation site [posttranslational modification] 134676011739 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676011740 ATP binding site [chemical binding]; other site 134676011741 Mg2+ binding site [ion binding]; other site 134676011742 G-X-G motif; other site 134676011743 Phosphotransferase enzyme family; Region: APH; pfam01636 134676011744 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 134676011745 active site 134676011746 ATP binding site [chemical binding]; other site 134676011747 substrate binding site [chemical binding]; other site 134676011748 short chain dehydrogenase; Provisional; Region: PRK06179 134676011749 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 134676011750 NAD(P) binding site [chemical binding]; other site 134676011751 active site 134676011752 5'-3' exonuclease; Region: 53EXOc; smart00475 134676011753 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 134676011754 active site 134676011755 metal binding site 1 [ion binding]; metal-binding site 134676011756 putative 5' ssDNA interaction site; other site 134676011757 metal binding site 3; metal-binding site 134676011758 metal binding site 2 [ion binding]; metal-binding site 134676011759 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 134676011760 putative DNA binding site [nucleotide binding]; other site 134676011761 putative metal binding site [ion binding]; other site 134676011762 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 134676011763 glucose-1-dehydrogenase; Provisional; Region: PRK06947 134676011764 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 134676011765 NAD(P) binding site [chemical binding]; other site 134676011766 active site 134676011767 PAS fold; Region: PAS_4; pfam08448 134676011768 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 134676011769 GAF domain; Region: GAF; pfam01590 134676011770 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 134676011771 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 134676011772 dimer interface [polypeptide binding]; other site 134676011773 phosphorylation site [posttranslational modification] 134676011774 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676011775 ATP binding site [chemical binding]; other site 134676011776 Mg2+ binding site [ion binding]; other site 134676011777 G-X-G motif; other site 134676011778 PAS domain; Region: PAS_9; pfam13426 134676011779 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 134676011780 putative active site [active] 134676011781 heme pocket [chemical binding]; other site 134676011782 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 134676011783 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 134676011784 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 134676011785 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 134676011786 dimer interface [polypeptide binding]; other site 134676011787 phosphorylation site [posttranslational modification] 134676011788 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676011789 ATP binding site [chemical binding]; other site 134676011790 Mg2+ binding site [ion binding]; other site 134676011791 G-X-G motif; other site 134676011792 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 134676011793 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 134676011794 dimer interface [polypeptide binding]; other site 134676011795 conserved gate region; other site 134676011796 putative PBP binding loops; other site 134676011797 ABC-ATPase subunit interface; other site 134676011798 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 134676011799 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 134676011800 dimer interface [polypeptide binding]; other site 134676011801 conserved gate region; other site 134676011802 putative PBP binding loops; other site 134676011803 ABC-ATPase subunit interface; other site 134676011804 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 134676011805 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 134676011806 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 134676011807 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 134676011808 DNA binding residues [nucleotide binding] 134676011809 HTH domain; Region: HTH_11; pfam08279 134676011810 WYL domain; Region: WYL; pfam13280 134676011811 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 134676011812 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 134676011813 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 134676011814 putative DNA binding site [nucleotide binding]; other site 134676011815 putative Zn2+ binding site [ion binding]; other site 134676011816 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676011817 metal binding site [ion binding]; metal-binding site 134676011818 active site 134676011819 I-site; other site 134676011820 Tubby C 2; Region: Tub_2; cl02043 134676011821 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 134676011822 Protease prsW family; Region: PrsW-protease; pfam13367 134676011823 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 134676011824 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 134676011825 S-adenosylmethionine binding site [chemical binding]; other site 134676011826 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 134676011827 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 134676011828 Major Facilitator Superfamily; Region: MFS_1; pfam07690 134676011829 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 134676011830 putative substrate translocation pore; other site 134676011831 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 134676011832 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 134676011833 dimerization interface [polypeptide binding]; other site 134676011834 putative DNA binding site [nucleotide binding]; other site 134676011835 putative Zn2+ binding site [ion binding]; other site 134676011836 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 134676011837 amphipathic channel; other site 134676011838 Asn-Pro-Ala signature motifs; other site 134676011839 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 134676011840 Low molecular weight phosphatase family; Region: LMWPc; cd00115 134676011841 active site 134676011842 Ricin-type beta-trefoil; Region: RICIN; smart00458 134676011843 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 134676011844 putative sugar binding sites [chemical binding]; other site 134676011845 Q-X-W motif; other site 134676011846 GAF domain; Region: GAF_3; pfam13492 134676011847 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 134676011848 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 134676011849 dimer interface [polypeptide binding]; other site 134676011850 phosphorylation site [posttranslational modification] 134676011851 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676011852 ATP binding site [chemical binding]; other site 134676011853 Mg2+ binding site [ion binding]; other site 134676011854 G-X-G motif; other site 134676011855 Response regulator receiver domain; Region: Response_reg; pfam00072 134676011856 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676011857 active site 134676011858 phosphorylation site [posttranslational modification] 134676011859 intermolecular recognition site; other site 134676011860 dimerization interface [polypeptide binding]; other site 134676011861 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 134676011862 PAS domain; Region: PAS_9; pfam13426 134676011863 putative active site [active] 134676011864 heme pocket [chemical binding]; other site 134676011865 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 134676011866 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 134676011867 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 134676011868 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 134676011869 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 134676011870 anti sigma factor interaction site; other site 134676011871 regulatory phosphorylation site [posttranslational modification]; other site 134676011872 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 134676011873 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 134676011874 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 134676011875 galactarate dehydratase; Region: galactar-dH20; TIGR03248 134676011876 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 134676011877 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 134676011878 Transcriptional regulators [Transcription]; Region: PurR; COG1609 134676011879 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 134676011880 DNA binding site [nucleotide binding] 134676011881 domain linker motif; other site 134676011882 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 134676011883 dimerization interface [polypeptide binding]; other site 134676011884 ligand binding site [chemical binding]; other site 134676011885 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 134676011886 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 134676011887 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 134676011888 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 134676011889 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 134676011890 dimer interface [polypeptide binding]; other site 134676011891 ADP-ribose binding site [chemical binding]; other site 134676011892 active site 134676011893 nudix motif; other site 134676011894 metal binding site [ion binding]; metal-binding site 134676011895 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676011896 Response regulator receiver domain; Region: Response_reg; pfam00072 134676011897 active site 134676011898 phosphorylation site [posttranslational modification] 134676011899 intermolecular recognition site; other site 134676011900 dimerization interface [polypeptide binding]; other site 134676011901 ferredoxin-NADP+ reductase; Region: PLN02852 134676011902 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 134676011903 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 134676011904 DNA-binding site [nucleotide binding]; DNA binding site 134676011905 RNA-binding motif; other site 134676011906 Predicted methyltransferase [General function prediction only]; Region: COG3897 134676011907 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 134676011908 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 134676011909 S-adenosylmethionine binding site [chemical binding]; other site 134676011910 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 134676011911 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676011912 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 134676011913 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 134676011914 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 134676011915 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 134676011916 DNA-binding site [nucleotide binding]; DNA binding site 134676011917 RNA-binding motif; other site 134676011918 NAD-dependent deacetylase; Provisional; Region: PRK00481 134676011919 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 134676011920 NAD+ binding site [chemical binding]; other site 134676011921 substrate binding site [chemical binding]; other site 134676011922 Zn binding site [ion binding]; other site 134676011923 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 134676011924 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 134676011925 NAD(P) binding site [chemical binding]; other site 134676011926 active site 134676011927 Transcriptional regulator [Transcription]; Region: LysR; COG0583 134676011928 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 134676011929 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436 134676011930 putative dimerization interface [polypeptide binding]; other site 134676011931 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 134676011932 Coenzyme A binding pocket [chemical binding]; other site 134676011933 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 134676011934 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 134676011935 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 134676011936 active site 134676011937 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 134676011938 putative triphosphate binding site [ion binding]; other site 134676011939 signature motif; other site 134676011940 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 134676011941 putative substrate translocation pore; other site 134676011942 GAF domain; Region: GAF; pfam01590 134676011943 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 134676011944 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676011945 metal binding site [ion binding]; metal-binding site 134676011946 active site 134676011947 I-site; other site 134676011948 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 134676011949 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 134676011950 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 134676011951 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 134676011952 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 134676011953 active site 134676011954 catalytic site [active] 134676011955 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 134676011956 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 134676011957 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 134676011958 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 134676011959 conserved cys residue [active] 134676011960 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 134676011961 classical (c) SDRs; Region: SDR_c; cd05233 134676011962 NAD(P) binding site [chemical binding]; other site 134676011963 active site 134676011964 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 134676011965 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 134676011966 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 134676011967 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 134676011968 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 134676011969 SPW repeat; Region: SPW; pfam03779 134676011970 Protein of unknown function (DUF1271); Region: DUF1271; pfam06902 134676011971 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 134676011972 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 134676011973 Cytochrome P450; Region: p450; cl12078 134676011974 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 134676011975 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676011976 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 134676011977 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 134676011978 MPN+ (JAMM) motif; other site 134676011979 Zinc-binding site [ion binding]; other site 134676011980 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 134676011981 dimer interface [polypeptide binding]; other site 134676011982 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 134676011983 phosphorylation site [posttranslational modification] 134676011984 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676011985 ATP binding site [chemical binding]; other site 134676011986 Mg2+ binding site [ion binding]; other site 134676011987 G-X-G motif; other site 134676011988 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 134676011989 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676011990 active site 134676011991 phosphorylation site [posttranslational modification] 134676011992 intermolecular recognition site; other site 134676011993 dimerization interface [polypeptide binding]; other site 134676011994 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 134676011995 DNA binding site [nucleotide binding] 134676011996 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 134676011997 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 134676011998 Moco binding site; other site 134676011999 metal coordination site [ion binding]; other site 134676012000 Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; cl17492 134676012001 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 134676012002 Ligand binding site; other site 134676012003 Putative Catalytic site; other site 134676012004 DXD motif; other site 134676012005 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 134676012006 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 134676012007 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 134676012008 active site 134676012009 DinB superfamily; Region: DinB_2; pfam12867 134676012010 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 134676012011 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 134676012012 putative metal binding site [ion binding]; other site 134676012013 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 134676012014 active site 134676012015 catalytic site [active] 134676012016 Predicted membrane protein (DUF2243); Region: DUF2243; cl01783 134676012017 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 134676012018 GAF domain; Region: GAF_2; pfam13185 134676012019 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676012020 metal binding site [ion binding]; metal-binding site 134676012021 active site 134676012022 I-site; other site 134676012023 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 134676012024 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 134676012025 active site 134676012026 catalytic residues [active] 134676012027 CHASE3 domain; Region: CHASE3; pfam05227 134676012028 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 134676012029 dimerization interface [polypeptide binding]; other site 134676012030 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 134676012031 dimer interface [polypeptide binding]; other site 134676012032 phosphorylation site [posttranslational modification] 134676012033 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676012034 ATP binding site [chemical binding]; other site 134676012035 Mg2+ binding site [ion binding]; other site 134676012036 G-X-G motif; other site 134676012037 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 134676012038 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 134676012039 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 134676012040 catalytic residue [active] 134676012041 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 134676012042 Alpha-L-arabinofuranosidase B, catalytic; Region: ArabFuran-catal; pfam09206 134676012043 Ricin-type beta-trefoil lectin domain-like; Region: RicinB_lectin_2; pfam14200 134676012044 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 134676012045 Ricin-type beta-trefoil lectin domain-like; Region: RicinB_lectin_2; pfam14200 134676012046 Class I aldolases; Region: Aldolase_Class_I; cl17187 134676012047 PilZ domain; Region: PilZ; pfam07238 134676012048 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 134676012049 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 134676012050 dimer interface [polypeptide binding]; other site 134676012051 active site 134676012052 CoA binding pocket [chemical binding]; other site 134676012053 Protein of unknown function (DUF419); Region: DUF419; cl15265 134676012054 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 134676012055 putative FMN binding site [chemical binding]; other site 134676012056 Uncharacterized conserved protein [Function unknown]; Region: COG2968 134676012057 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 134676012058 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 134676012059 Coenzyme A binding pocket [chemical binding]; other site 134676012060 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 134676012061 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 134676012062 Alpha-L-arabinofuranosidase B, catalytic; Region: ArabFuran-catal; pfam09206 134676012063 Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270 134676012064 Cellulose binding domain; Region: CBM_2; pfam00553 134676012065 Alpha-L-arabinofuranosidase B, catalytic; Region: ArabFuran-catal; pfam09206 134676012066 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 134676012067 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 134676012068 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 134676012069 Ligand binding site; other site 134676012070 Putative Catalytic site; other site 134676012071 DXD motif; other site 134676012072 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cl00630 134676012073 putative active site [active] 134676012074 Transmembrane secretion effector; Region: MFS_3; pfam05977 134676012075 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 134676012076 putative substrate translocation pore; other site 134676012077 ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism]; Region: AbcD; COG2011 134676012078 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 134676012079 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 134676012080 Walker A/P-loop; other site 134676012081 ATP binding site [chemical binding]; other site 134676012082 Q-loop/lid; other site 134676012083 ABC transporter signature motif; other site 134676012084 Walker B; other site 134676012085 D-loop; other site 134676012086 H-loop/switch region; other site 134676012087 NIL domain; Region: NIL; pfam09383 134676012088 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 134676012089 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 134676012090 Predicted acetyltransferase [General function prediction only]; Region: COG3393 134676012091 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 134676012092 Coenzyme A binding pocket [chemical binding]; other site 134676012093 potential frameshift: common BLAST hit: gi|312196253|ref|YP_004016314.1| peptidase M20 134676012094 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 134676012095 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 134676012096 carboxylate-amine ligase; Provisional; Region: PRK13517 134676012097 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 134676012098 Predicted transcriptional regulators [Transcription]; Region: COG1695 134676012099 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 134676012100 putative DNA binding site [nucleotide binding]; other site 134676012101 putative Zn2+ binding site [ion binding]; other site 134676012102 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 134676012103 putative catalytic residues [active] 134676012104 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 134676012105 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 134676012106 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 134676012107 dimer interface [polypeptide binding]; other site 134676012108 pyridoxal 5'-phosphate binding site [chemical binding]; other site 134676012109 catalytic residue [active] 134676012110 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 134676012111 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 134676012112 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 134676012113 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 134676012114 putative NAD(P) binding site [chemical binding]; other site 134676012115 putative substrate binding site [chemical binding]; other site 134676012116 catalytic Zn binding site [ion binding]; other site 134676012117 structural Zn binding site [ion binding]; other site 134676012118 dimer interface [polypeptide binding]; other site 134676012119 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 134676012120 salt bridge; other site 134676012121 non-specific DNA binding site [nucleotide binding]; other site 134676012122 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 134676012123 sequence-specific DNA binding site [nucleotide binding]; other site 134676012124 Family description; Region: VCBS; pfam13517 134676012125 Family description; Region: VCBS; pfam13517 134676012126 Family description; Region: VCBS; pfam13517 134676012127 Family description; Region: VCBS; pfam13517 134676012128 L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 134676012129 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 134676012130 putative N- and C-terminal domain interface [polypeptide binding]; other site 134676012131 putative active site [active] 134676012132 MgATP binding site [chemical binding]; other site 134676012133 catalytic site [active] 134676012134 metal binding site [ion binding]; metal-binding site 134676012135 putative carbohydrate binding site [chemical binding]; other site 134676012136 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 134676012137 hydrophobic ligand binding site; other site 134676012138 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 134676012139 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 134676012140 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 134676012141 sequence-specific DNA binding site [nucleotide binding]; other site 134676012142 salt bridge; other site 134676012143 Vesicle coat complex, various subunits [Intracellular trafficking and secretion]; Region: COG5096 134676012144 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 134676012145 DNA binding site [nucleotide binding] 134676012146 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 134676012147 AAA ATPase domain; Region: AAA_16; pfam13191 134676012148 NB-ARC domain; Region: NB-ARC; pfam00931 134676012149 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 134676012150 binding surface 134676012151 TPR motif; other site 134676012152 Tetratricopeptide repeat; Region: TPR_12; pfam13424 134676012153 Tetratricopeptide repeat; Region: TPR_12; pfam13424 134676012154 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 134676012155 binding surface 134676012156 TPR motif; other site 134676012157 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 134676012158 putative catalytic site [active] 134676012159 putative phosphate binding site [ion binding]; other site 134676012160 putative metal binding site [ion binding]; other site 134676012161 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 134676012162 calcium mediated ligand binding site; other site 134676012163 intermolecular salt bridges; other site 134676012164 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 134676012165 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 134676012166 putative sugar binding sites [chemical binding]; other site 134676012167 Q-X-W motif; other site 134676012168 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 134676012169 Tetratricopeptide repeat; Region: TPR_12; pfam13424 134676012170 Tetratricopeptide repeat; Region: TPR_12; pfam13424 134676012171 Tetratricopeptide repeat; Region: TPR_10; pfam13374 134676012172 Tetratricopeptide repeat; Region: TPR_12; pfam13424 134676012173 Tetratricopeptide repeat; Region: TPR_12; pfam13424 134676012174 Tetratricopeptide repeat; Region: TPR_12; pfam13424 134676012175 Tetratricopeptide repeat; Region: TPR_10; pfam13374 134676012176 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 134676012177 synthetase active site [active] 134676012178 NTP binding site [chemical binding]; other site 134676012179 metal binding site [ion binding]; metal-binding site 134676012180 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 134676012181 EamA-like transporter family; Region: EamA; pfam00892 134676012182 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 134676012183 CGNR zinc finger; Region: zf-CGNR; pfam11706 134676012184 Predicted transcriptional regulator [Transcription]; Region: COG2378 134676012185 HTH domain; Region: HTH_11; pfam08279 134676012186 WYL domain; Region: WYL; pfam13280 134676012187 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 134676012188 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 134676012189 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 134676012190 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 134676012191 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 134676012192 catalytic triad [active] 134676012193 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 134676012194 Ligand binding site; other site 134676012195 Putative Catalytic site; other site 134676012196 DXD motif; other site 134676012197 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 134676012198 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 134676012199 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 134676012200 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 134676012201 metal binding site [ion binding]; metal-binding site 134676012202 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 134676012203 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 134676012204 dimer interface [polypeptide binding]; other site 134676012205 phosphorylation site [posttranslational modification] 134676012206 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676012207 ATP binding site [chemical binding]; other site 134676012208 Mg2+ binding site [ion binding]; other site 134676012209 G-X-G motif; other site 134676012210 Response regulator receiver domain; Region: Response_reg; pfam00072 134676012211 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676012212 active site 134676012213 phosphorylation site [posttranslational modification] 134676012214 intermolecular recognition site; other site 134676012215 dimerization interface [polypeptide binding]; other site 134676012216 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 134676012217 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 134676012218 dimer interface [polypeptide binding]; other site 134676012219 phosphorylation site [posttranslational modification] 134676012220 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676012221 ATP binding site [chemical binding]; other site 134676012222 Mg2+ binding site [ion binding]; other site 134676012223 G-X-G motif; other site 134676012224 flagellin; Reviewed; Region: PRK12688 134676012225 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 134676012226 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 134676012227 active site 134676012228 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 134676012229 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 134676012230 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 134676012231 active site 134676012232 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 134676012233 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676012234 active site 134676012235 phosphorylation site [posttranslational modification] 134676012236 intermolecular recognition site; other site 134676012237 dimerization interface [polypeptide binding]; other site 134676012238 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 134676012239 DNA binding site [nucleotide binding] 134676012240 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 134676012241 active site 134676012242 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 134676012243 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 134676012244 dimer interface [polypeptide binding]; other site 134676012245 phosphorylation site [posttranslational modification] 134676012246 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676012247 ATP binding site [chemical binding]; other site 134676012248 Mg2+ binding site [ion binding]; other site 134676012249 G-X-G motif; other site 134676012250 Response regulator receiver domain; Region: Response_reg; pfam00072 134676012251 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676012252 active site 134676012253 phosphorylation site [posttranslational modification] 134676012254 intermolecular recognition site; other site 134676012255 dimerization interface [polypeptide binding]; other site 134676012256 Hpt domain; Region: Hpt; pfam01627 134676012257 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 134676012258 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 134676012259 Coenzyme A binding pocket [chemical binding]; other site 134676012260 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 134676012261 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 134676012262 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 134676012263 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 134676012264 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676012265 metal binding site [ion binding]; metal-binding site 134676012266 active site 134676012267 I-site; other site 134676012268 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 134676012269 protein-splicing catalytic site; other site 134676012270 thioester formation/cholesterol transfer; other site 134676012271 Pretoxin HINT domain; Region: PT-HINT; pfam07591 134676012272 AAA domain; Region: AAA_31; pfam13614 134676012273 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 134676012274 short chain dehydrogenase; Provisional; Region: PRK08263 134676012275 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 134676012276 NADP binding site [chemical binding]; other site 134676012277 active site 134676012278 steroid binding site; other site 134676012279 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676012280 metal binding site [ion binding]; metal-binding site 134676012281 active site 134676012282 I-site; other site 134676012283 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 134676012284 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 134676012285 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 134676012286 active site 134676012287 catalytic tetrad [active] 134676012288 N-terminal catalytic domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_N; cl15675 134676012289 active site 134676012290 catalytic site [active] 134676012291 Middle domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_M; cd10316 134676012292 C-terminal domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_C; cd10317 134676012293 Ca binding site [ion binding]; other site 134676012294 substrate binding site [chemical binding]; other site 134676012295 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 134676012296 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 134676012297 NodB motif; other site 134676012298 active site 134676012299 catalytic site [active] 134676012300 metal binding site [ion binding]; metal-binding site 134676012301 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 134676012302 Uncharacterized conserved protein [Function unknown]; Region: COG3391 134676012303 Domain of unknown function (DUF4360); Region: DUF4360; pfam14273 134676012304 Domain of unknown function (DUF4360); Region: DUF4360; pfam14273 134676012305 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 134676012306 NHL repeat; Region: NHL; pfam01436 134676012307 NHL repeat; Region: NHL; pfam01436 134676012308 NHL repeat; Region: NHL; pfam01436 134676012309 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 134676012310 AIR carboxylase; Region: AIRC; cl00310 134676012311 hypothetical protein; Provisional; Region: PRK04194 134676012312 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 134676012313 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 134676012314 catalytic residues [active] 134676012315 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 134676012316 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 134676012317 PAS fold; Region: PAS_4; pfam08448 134676012318 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 134676012319 putative active site [active] 134676012320 heme pocket [chemical binding]; other site 134676012321 PAS domain; Region: PAS_9; pfam13426 134676012322 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 134676012323 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 134676012324 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 134676012325 dimerization interface [polypeptide binding]; other site 134676012326 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 134676012327 dimer interface [polypeptide binding]; other site 134676012328 putative CheW interface [polypeptide binding]; other site 134676012329 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 134676012330 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676012331 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 134676012332 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 134676012333 putative substrate translocation pore; other site 134676012334 AAA ATPase domain; Region: AAA_16; pfam13191 134676012335 AAA domain; Region: AAA_22; pfam13401 134676012336 AAA ATPase domain; Region: AAA_16; pfam13191 134676012337 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 134676012338 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 134676012339 DNA binding residues [nucleotide binding] 134676012340 dimerization interface [polypeptide binding]; other site 134676012341 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 134676012342 S-adenosylmethionine binding site [chemical binding]; other site 134676012343 Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457 134676012344 Catalytic NodB homology domain of Streptomyces lividans acetylxylan esterase and its bacterial homologs; Region: CE4_SlAXE_like; cd10953 134676012345 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 134676012346 NodB motif; other site 134676012347 active site 134676012348 catalytic site [active] 134676012349 Zn binding site [ion binding]; other site 134676012350 dimer interface [polypeptide binding]; other site 134676012351 PAS domain; Region: PAS_9; pfam13426 134676012352 PAS fold; Region: PAS_4; pfam08448 134676012353 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 134676012354 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 134676012355 dimer interface [polypeptide binding]; other site 134676012356 phosphorylation site [posttranslational modification] 134676012357 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676012358 ATP binding site [chemical binding]; other site 134676012359 Mg2+ binding site [ion binding]; other site 134676012360 G-X-G motif; other site 134676012361 sugar efflux transporter; Region: 2A0120; TIGR00899 134676012362 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 134676012363 Domain of unknown function (DUF4265); Region: DUF4265; pfam14085 134676012364 Family description; Region: VCBS; pfam13517 134676012365 Family description; Region: VCBS; pfam13517 134676012366 Family description; Region: VCBS; pfam13517 134676012367 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 134676012368 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 134676012369 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 134676012370 putative active site [active] 134676012371 metal binding site [ion binding]; metal-binding site 134676012372 Transcriptional regulators [Transcription]; Region: MarR; COG1846 134676012373 MarR family; Region: MarR; pfam01047 134676012374 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 134676012375 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 134676012376 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 134676012377 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 134676012378 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 134676012379 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 134676012380 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 134676012381 SEC-C motif; Region: SEC-C; pfam02810 134676012382 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 134676012383 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 134676012384 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 134676012385 E3 interaction surface; other site 134676012386 lipoyl attachment site [posttranslational modification]; other site 134676012387 e3 binding domain; Region: E3_binding; pfam02817 134676012388 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 134676012389 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 134676012390 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 134676012391 alpha subunit interface [polypeptide binding]; other site 134676012392 TPP binding site [chemical binding]; other site 134676012393 heterodimer interface [polypeptide binding]; other site 134676012394 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 134676012395 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 134676012396 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 134676012397 tetramer interface [polypeptide binding]; other site 134676012398 TPP-binding site [chemical binding]; other site 134676012399 heterodimer interface [polypeptide binding]; other site 134676012400 phosphorylation loop region [posttranslational modification] 134676012401 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 134676012402 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 134676012403 putative DNA binding site [nucleotide binding]; other site 134676012404 putative Zn2+ binding site [ion binding]; other site 134676012405 AsnC family; Region: AsnC_trans_reg; pfam01037 134676012406 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 134676012407 SnoaL-like domain; Region: SnoaL_2; pfam12680 134676012408 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 134676012409 Domain of unknown function (DUF1990); Region: DUF1990; pfam09348 134676012410 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 134676012411 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 134676012412 tetramer interface [polypeptide binding]; other site 134676012413 pyridoxal 5'-phosphate binding site [chemical binding]; other site 134676012414 catalytic residue [active] 134676012415 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676012416 metal binding site [ion binding]; metal-binding site 134676012417 active site 134676012418 I-site; other site 134676012419 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 134676012420 Domain of unknown function (DUF397); Region: DUF397; pfam04149 134676012421 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 134676012422 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 134676012423 non-specific DNA binding site [nucleotide binding]; other site 134676012424 salt bridge; other site 134676012425 sequence-specific DNA binding site [nucleotide binding]; other site 134676012426 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 134676012427 Chromate transporter; Region: Chromate_transp; pfam02417 134676012428 Chromate transporter; Region: Chromate_transp; pfam02417 134676012429 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 134676012430 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 134676012431 tetracycline repressor protein TetR; Provisional; Region: PRK13756 134676012432 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676012433 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 134676012434 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 134676012435 putative substrate translocation pore; other site 134676012436 Mor transcription activator family; Region: Mor; cl02360 134676012437 Homeodomain-like domain; Region: HTH_23; cl17451 134676012438 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 134676012439 dimerization interface [polypeptide binding]; other site 134676012440 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 134676012441 dimer interface [polypeptide binding]; other site 134676012442 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 134676012443 putative CheW interface [polypeptide binding]; other site 134676012444 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 134676012445 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 134676012446 binding surface 134676012447 TPR motif; other site 134676012448 CHAT domain; Region: CHAT; pfam12770 134676012449 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 134676012450 active site 134676012451 catalytic residues [active] 134676012452 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 134676012453 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 134676012454 RibD C-terminal domain; Region: RibD_C; cl17279 134676012455 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 134676012456 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 134676012457 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676012458 metal binding site [ion binding]; metal-binding site 134676012459 active site 134676012460 I-site; other site 134676012461 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 134676012462 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 134676012463 Ricin-type beta-trefoil; Region: RICIN; smart00458 134676012464 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 134676012465 putative sugar binding sites [chemical binding]; other site 134676012466 Q-X-W motif; other site 134676012467 Fungal chitosanase of glycosyl hydrolase group 75; Region: Glyco_hydro_75; pfam07335 134676012468 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 134676012469 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 134676012470 Coenzyme A binding pocket [chemical binding]; other site 134676012471 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 134676012472 rRNA binding site [nucleotide binding]; other site 134676012473 predicted 30S ribosome binding site; other site 134676012474 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 134676012475 Fatty acid desaturase; Region: FA_desaturase; pfam00487 134676012476 Di-iron ligands [ion binding]; other site 134676012477 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 134676012478 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676012479 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 134676012480 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 134676012481 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 134676012482 active site 134676012483 Zn binding site [ion binding]; other site 134676012484 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 134676012485 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 134676012486 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 134676012487 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 134676012488 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 134676012489 Acyltransferase family; Region: Acyl_transf_3; pfam01757 134676012490 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 134676012491 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 134676012492 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 134676012493 DNA binding residues [nucleotide binding] 134676012494 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 134676012495 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 134676012496 active site 134676012497 metal binding site [ion binding]; metal-binding site 134676012498 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 134676012499 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 134676012500 DNA binding residues [nucleotide binding] 134676012501 drug binding residues [chemical binding]; other site 134676012502 dimer interface [polypeptide binding]; other site 134676012503 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 134676012504 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 134676012505 Low affinity iron permease; Region: Iron_permease; cl12096 134676012506 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676012507 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 134676012508 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 134676012509 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 134676012510 Glycosyl hydrolase family 12; Region: Glyco_hydro_12; cl03302 134676012511 Cellulose binding domain; Region: CBM_2; pfam00553 134676012512 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 134676012513 active site 134676012514 Zn binding site [ion binding]; other site 134676012515 Transcriptional regulators [Transcription]; Region: PurR; COG1609 134676012516 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 134676012517 DNA binding site [nucleotide binding] 134676012518 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 134676012519 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 134676012520 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 134676012521 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 134676012522 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 134676012523 Mg++ binding site [ion binding]; other site 134676012524 putative catalytic motif [active] 134676012525 putative substrate binding site [chemical binding]; other site 134676012526 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 134676012527 active site 134676012528 catalytic residues [active] 134676012529 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 134676012530 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 134676012531 NAD(P) binding site [chemical binding]; other site 134676012532 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 134676012533 AAA domain; Region: AAA_33; pfam13671 134676012534 AAA domain; Region: AAA_17; pfam13207 134676012535 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 134676012536 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 134676012537 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 134676012538 putative sugar binding sites [chemical binding]; other site 134676012539 Q-X-W motif; other site 134676012540 Glycosyl hydrolase family 62, characterized arabinofuranosidases; Region: GH62; cd08987 134676012541 active site 134676012542 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 134676012543 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 134676012544 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 134676012545 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676012546 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 134676012547 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 134676012548 dimerization interface [polypeptide binding]; other site 134676012549 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 134676012550 dimer interface [polypeptide binding]; other site 134676012551 putative CheW interface [polypeptide binding]; other site 134676012552 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 134676012553 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 134676012554 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 134676012555 catalytic residue [active] 134676012556 probable polyamine oxidase; Region: PLN02268 134676012557 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 134676012558 Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324 134676012559 NADP binding site [chemical binding]; other site 134676012560 substrate binding site [chemical binding]; other site 134676012561 active site 134676012562 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 134676012563 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 134676012564 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 134676012565 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 134676012566 spore photoproduct lyase family protein; Region: lyase_spl_fam; TIGR03886 134676012567 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 134676012568 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 134676012569 Major Facilitator Superfamily; Region: MFS_1; pfam07690 134676012570 putative substrate translocation pore; other site 134676012571 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676012572 Protein of unknown function DUF72; Region: DUF72; pfam01904 134676012573 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 134676012574 sugar binding site [chemical binding]; other site 134676012575 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 134676012576 sugar binding site [chemical binding]; other site 134676012577 Streptomyces laminarinase-like, member of glycosyl hydrolase family 16; Region: GH16_Strep_laminarinase_like; cd02182 134676012578 active site 134676012579 catalytic residues [active] 134676012580 Glucanosyltransferase; Region: Glyco_hydro_72; pfam03198 134676012581 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 134676012582 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 134676012583 Domain of unknown function (DUF305); Region: DUF305; cl17794 134676012584 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 134676012585 sugar binding site [chemical binding]; other site 134676012586 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 134676012587 Transcriptional regulators [Transcription]; Region: PurR; COG1609 134676012588 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 134676012589 DNA binding site [nucleotide binding] 134676012590 domain linker motif; other site 134676012591 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 134676012592 putative dimerization interface [polypeptide binding]; other site 134676012593 putative ligand binding site [chemical binding]; other site 134676012594 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 134676012595 Transposase; Region: DEDD_Tnp_IS110; pfam01548 134676012596 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 134676012597 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 134676012598 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 134676012599 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 134676012600 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676012601 A subgroup of the Glycosyl hydrolase family 20 (GH20) catalytic domain found in proteins similar to the N-acetylhexosaminidase from Streptomyces plicatus (SpHex). SpHex catalyzes the hydrolysis of N-acetyl-beta-hexosaminides. An Asp residue within the...; Region: GH20_SpHex_like; cd06568 134676012602 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 134676012603 active site 134676012604 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 134676012605 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 134676012606 Uncharacterized conserved protein [Function unknown]; Region: COG0393 134676012607 Uncharacterized conserved protein [Function unknown]; Region: COG0393 134676012608 Hemerythrin-like domain; Region: Hr-like; cd12108 134676012609 Fe binding site [ion binding]; other site 134676012610 CHAT domain; Region: CHAT; cl17868 134676012611 Predicted transcriptional regulators [Transcription]; Region: COG1695 134676012612 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 134676012613 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 134676012614 AAA ATPase domain; Region: AAA_16; pfam13191 134676012615 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 134676012616 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 134676012617 DNA binding residues [nucleotide binding] 134676012618 dimerization interface [polypeptide binding]; other site 134676012619 Pectate lyase; Region: Pec_lyase_C; cl01593 134676012620 Right handed beta helix region; Region: Beta_helix; pfam13229 134676012621 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 134676012622 Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025 134676012623 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 134676012624 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 134676012625 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 134676012626 Major Facilitator Superfamily; Region: MFS_1; pfam07690 134676012627 putative substrate translocation pore; other site 134676012628 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 134676012629 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 134676012630 NAD(P) binding site [chemical binding]; other site 134676012631 active site 134676012632 Domain of unknown function (DUF1772); Region: DUF1772; cl12097 134676012633 Cupin; Region: Cupin_6; pfam12852 134676012634 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 134676012635 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 134676012636 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 134676012637 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in uncharacterized protein from Archaeoglobus fulgidus (Af0060) and its bacterial homologs; Region: NTP-PPase_Af0060_like; cd11533 134676012638 homodimer interface [polypeptide binding]; other site 134676012639 metal binding site [ion binding]; metal-binding site 134676012640 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 134676012641 Winged helix-turn helix; Region: HTH_29; pfam13551 134676012642 Integrase core domain; Region: rve; pfam00665 134676012643 Integrase core domain; Region: rve_3; pfam13683 134676012644 radical SAM protein, MSMEG_0568 family; Region: rSAM_MSMEG_0568; TIGR04043 134676012645 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 134676012646 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 134676012647 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 134676012648 Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270 134676012649 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 134676012650 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 134676012651 Trp docking motif [polypeptide binding]; other site 134676012652 active site 134676012653 PQQ-like domain; Region: PQQ_2; pfam13360 134676012654 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 134676012655 Phosphotransferase enzyme family; Region: APH; pfam01636 134676012656 active site 134676012657 substrate binding site [chemical binding]; other site 134676012658 ATP binding site [chemical binding]; other site 134676012659 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 134676012660 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 134676012661 Coenzyme A binding pocket [chemical binding]; other site 134676012662 potential frameshift: common BLAST hit: gi|291298056|ref|YP_003509334.1| ABC transporter-like protein 134676012663 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 134676012664 Walker A/P-loop; other site 134676012665 ATP binding site [chemical binding]; other site 134676012666 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 134676012667 Q-loop/lid; other site 134676012668 ABC transporter signature motif; other site 134676012669 Walker B; other site 134676012670 D-loop; other site 134676012671 H-loop/switch region; other site 134676012672 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 134676012673 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 134676012674 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 134676012675 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 134676012676 active site 134676012677 Tyrosinase co-factor MelC1; Region: MelC1; pfam06236 134676012678 Common central domain of tyrosinase; Region: Tyrosinase; pfam00264 134676012679 Tyrosinase co-factor MelC1; Region: MelC1; pfam06236 134676012680 Pectinesterase; Region: Pectinesterase; pfam01095 134676012681 putative pectinesterase; Region: PLN02432; cl01911 134676012682 Amb_all domain; Region: Amb_all; smart00656 134676012683 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 134676012684 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 134676012685 active site 134676012686 ATP binding site [chemical binding]; other site 134676012687 substrate binding site [chemical binding]; other site 134676012688 activation loop (A-loop); other site 134676012689 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 134676012690 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 134676012691 DNA-binding site [nucleotide binding]; DNA binding site 134676012692 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 134676012693 pyridoxal 5'-phosphate binding site [chemical binding]; other site 134676012694 homodimer interface [polypeptide binding]; other site 134676012695 catalytic residue [active] 134676012696 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 134676012697 EamA-like transporter family; Region: EamA; pfam00892 134676012698 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 134676012699 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 134676012700 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 134676012701 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 134676012702 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 134676012703 dimer interface [polypeptide binding]; other site 134676012704 active site 134676012705 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 134676012706 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 134676012707 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 134676012708 Isochorismatase family; Region: Isochorismatase; pfam00857 134676012709 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 134676012710 catalytic triad [active] 134676012711 conserved cis-peptide bond; other site 134676012712 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 134676012713 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 134676012714 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 134676012715 Walker A motif; other site 134676012716 ATP binding site [chemical binding]; other site 134676012717 Walker B motif; other site 134676012718 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 134676012719 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 134676012720 DinB superfamily; Region: DinB_2; pfam12867 134676012721 Protein of unknown function (DUF1203); Region: DUF1203; pfam06718 134676012722 Helix-turn-helix domain; Region: HTH_17; pfam12728 134676012723 Uncharacterized conserved protein (DUF2203); Region: DUF2203; cl02056 134676012724 PAS domain S-box; Region: sensory_box; TIGR00229 134676012725 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 134676012726 putative active site [active] 134676012727 heme pocket [chemical binding]; other site 134676012728 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 134676012729 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676012730 metal binding site [ion binding]; metal-binding site 134676012731 active site 134676012732 I-site; other site 134676012733 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 134676012734 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 134676012735 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 134676012736 Walker A motif; other site 134676012737 ATP binding site [chemical binding]; other site 134676012738 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 134676012739 metal ion-dependent adhesion site (MIDAS); other site 134676012740 FAD binding domain; Region: FAD_binding_3; pfam01494 134676012741 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 134676012742 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 134676012743 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 134676012744 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 134676012745 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 134676012746 Coenzyme A binding pocket [chemical binding]; other site 134676012747 N-acetyltransferase; Region: Acetyltransf_2; cl00949 134676012748 conserved repeat domain; Region: B_ant_repeat; TIGR01451 134676012749 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 134676012750 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 134676012751 HIGH motif; other site 134676012752 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 134676012753 active site 134676012754 KMSKS motif; other site 134676012755 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 134676012756 tRNA binding surface [nucleotide binding]; other site 134676012757 anticodon binding site; other site 134676012758 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14951 134676012759 Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are...; Region: NDPk; cl00335 134676012760 active site 134676012761 multimer interface [polypeptide binding]; other site 134676012762 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 134676012763 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676012764 active site 134676012765 phosphorylation site [posttranslational modification] 134676012766 intermolecular recognition site; other site 134676012767 dimerization interface [polypeptide binding]; other site 134676012768 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 134676012769 DNA binding site [nucleotide binding] 134676012770 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 134676012771 dimerization interface [polypeptide binding]; other site 134676012772 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 134676012773 dimer interface [polypeptide binding]; other site 134676012774 phosphorylation site [posttranslational modification] 134676012775 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676012776 ATP binding site [chemical binding]; other site 134676012777 Mg2+ binding site [ion binding]; other site 134676012778 G-X-G motif; other site 134676012779 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 134676012780 active site 134676012781 substrate binding site [chemical binding]; other site 134676012782 ATP binding site [chemical binding]; other site 134676012783 Phosphotransferase enzyme family; Region: APH; pfam01636 134676012784 Predicted membrane protein [Function unknown]; Region: COG2246 134676012785 GtrA-like protein; Region: GtrA; pfam04138 134676012786 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 134676012787 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 134676012788 dimer interface [polypeptide binding]; other site 134676012789 active site 134676012790 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 134676012791 Ligand Binding Site [chemical binding]; other site 134676012792 Molecular Tunnel; other site 134676012793 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 134676012794 Walker A/P-loop; other site 134676012795 ATP binding site [chemical binding]; other site 134676012796 Q-loop/lid; other site 134676012797 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 134676012798 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 134676012799 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 134676012800 Walker A/P-loop; other site 134676012801 ATP binding site [chemical binding]; other site 134676012802 Q-loop/lid; other site 134676012803 ABC transporter signature motif; other site 134676012804 Walker B; other site 134676012805 D-loop; other site 134676012806 H-loop/switch region; other site 134676012807 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 134676012808 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 134676012809 DNA binding residues [nucleotide binding] 134676012810 Bifunctional nuclease; Region: DNase-RNase; pfam02577 134676012811 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 134676012812 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 134676012813 DNA binding residues [nucleotide binding] 134676012814 dimer interface [polypeptide binding]; other site 134676012815 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 134676012816 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 134676012817 phosphopeptide binding site; other site 134676012818 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 134676012819 lipoyl attachment site [posttranslational modification]; other site 134676012820 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 134676012821 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 134676012822 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 134676012823 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 134676012824 RNA polymerase factor sigma-70; Validated; Region: PRK08241 134676012825 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 134676012826 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 134676012827 DNA binding residues [nucleotide binding] 134676012828 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 134676012829 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 134676012830 Helix-turn-helix domain; Region: HTH_18; pfam12833 134676012831 Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891 134676012832 putative hydrophobic ligand binding site [chemical binding]; other site 134676012833 CLM binding site; other site 134676012834 L1 loop; other site 134676012835 DNA binding site [nucleotide binding] 134676012836 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 134676012837 dimerization interface [polypeptide binding]; other site 134676012838 putative DNA binding site [nucleotide binding]; other site 134676012839 putative Zn2+ binding site [ion binding]; other site 134676012840 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 134676012841 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 134676012842 metal ion-dependent adhesion site (MIDAS); other site 134676012843 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 134676012844 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 134676012845 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 134676012846 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676012847 metal binding site [ion binding]; metal-binding site 134676012848 active site 134676012849 I-site; other site 134676012850 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 134676012851 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 134676012852 Walker A/P-loop; other site 134676012853 ATP binding site [chemical binding]; other site 134676012854 Q-loop/lid; other site 134676012855 ABC transporter signature motif; other site 134676012856 Walker B; other site 134676012857 D-loop; other site 134676012858 H-loop/switch region; other site 134676012859 ABC transporter; Region: ABC_tran_2; pfam12848 134676012860 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 134676012861 Domain of unknown function (DUF385); Region: DUF385; cl04387 134676012862 The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cd05467 134676012863 starch-binding site 2 [chemical binding]; other site 134676012864 starch-binding site 1 [chemical binding]; other site 134676012865 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 134676012866 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 134676012867 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 134676012868 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676012869 metal binding site [ion binding]; metal-binding site 134676012870 active site 134676012871 I-site; other site 134676012872 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 134676012873 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 134676012874 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 134676012875 ligand binding site; other site 134676012876 oligomer interface; other site 134676012877 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 134676012878 dimer interface [polypeptide binding]; other site 134676012879 N-terminal domain interface [polypeptide binding]; other site 134676012880 sulfate 1 binding site; other site 134676012881 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676012882 metal binding site [ion binding]; metal-binding site 134676012883 active site 134676012884 I-site; other site 134676012885 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 134676012886 Glyco_18 domain; Region: Glyco_18; smart00636 134676012887 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 134676012888 active site 134676012889 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 134676012890 nudix motif; other site 134676012891 Helix-turn-helix domain; Region: HTH_18; pfam12833 134676012892 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 134676012893 Domain of unknown function (DUF4331); Region: DUF4331; pfam14224 134676012894 Chitin binding domain; Region: Chitin_bind_3; pfam03067 134676012895 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 134676012896 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 134676012897 RNA binding surface [nucleotide binding]; other site 134676012898 Domains similar to the eukaryotic reeler domain and bacterial cohesins; Region: Reeler_cohesin_like; cl14606 134676012899 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 134676012900 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 134676012901 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 134676012902 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 134676012903 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 134676012904 anti sigma factor interaction site; other site 134676012905 regulatory phosphorylation site [posttranslational modification]; other site 134676012906 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 134676012907 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 134676012908 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 134676012909 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 134676012910 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 134676012911 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 134676012912 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 134676012913 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 134676012914 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 134676012915 TM-ABC transporter signature motif; other site 134676012916 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 134676012917 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 134676012918 Walker A/P-loop; other site 134676012919 ATP binding site [chemical binding]; other site 134676012920 Q-loop/lid; other site 134676012921 ABC transporter signature motif; other site 134676012922 Walker B; other site 134676012923 D-loop; other site 134676012924 H-loop/switch region; other site 134676012925 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 134676012926 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 134676012927 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 134676012928 putative ligand binding site [chemical binding]; other site 134676012929 L-arabinose isomerase; Provisional; Region: PRK02929 134676012930 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 134676012931 hexamer (dimer of trimers) interface [polypeptide binding]; other site 134676012932 trimer interface [polypeptide binding]; other site 134676012933 substrate binding site [chemical binding]; other site 134676012934 Mn binding site [ion binding]; other site 134676012935 Transcriptional regulators [Transcription]; Region: PurR; COG1609 134676012936 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 134676012937 DNA binding site [nucleotide binding] 134676012938 domain linker motif; other site 134676012939 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 134676012940 ligand binding site [chemical binding]; other site 134676012941 dimerization interface (open form) [polypeptide binding]; other site 134676012942 dimerization interface (closed form) [polypeptide binding]; other site 134676012943 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 134676012944 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 134676012945 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 134676012946 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 134676012947 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 134676012948 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 134676012949 Tetratricopeptide repeat; Region: TPR_12; pfam13424 134676012950 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 134676012951 binding surface 134676012952 TPR motif; other site 134676012953 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 134676012954 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676012955 metal binding site [ion binding]; metal-binding site 134676012956 active site 134676012957 I-site; other site 134676012958 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 134676012959 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 134676012960 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 134676012961 FtsX-like permease family; Region: FtsX; pfam02687 134676012962 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 134676012963 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 134676012964 Walker A/P-loop; other site 134676012965 ATP binding site [chemical binding]; other site 134676012966 Q-loop/lid; other site 134676012967 ABC transporter signature motif; other site 134676012968 Walker B; other site 134676012969 D-loop; other site 134676012970 H-loop/switch region; other site 134676012971 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 134676012972 HlyD family secretion protein; Region: HlyD_3; pfam13437 134676012973 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 134676012974 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 134676012975 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 134676012976 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 134676012977 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 134676012978 Acyltransferase family; Region: Acyl_transf_3; pfam01757 134676012979 CheW-like domain; Region: CheW; pfam01584 134676012980 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 134676012981 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 134676012982 CheW-like domain; Region: CheW; pfam01584 134676012983 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 134676012984 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 134676012985 dimer interface [polypeptide binding]; other site 134676012986 putative CheW interface [polypeptide binding]; other site 134676012987 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 134676012988 putative binding surface; other site 134676012989 active site 134676012990 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 134676012991 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676012992 ATP binding site [chemical binding]; other site 134676012993 Mg2+ binding site [ion binding]; other site 134676012994 G-X-G motif; other site 134676012995 Response regulator receiver domain; Region: Response_reg; pfam00072 134676012996 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676012997 active site 134676012998 phosphorylation site [posttranslational modification] 134676012999 intermolecular recognition site; other site 134676013000 dimerization interface [polypeptide binding]; other site 134676013001 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 134676013002 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676013003 active site 134676013004 phosphorylation site [posttranslational modification] 134676013005 intermolecular recognition site; other site 134676013006 dimerization interface [polypeptide binding]; other site 134676013007 CheB methylesterase; Region: CheB_methylest; pfam01339 134676013008 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 134676013009 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676013010 active site 134676013011 phosphorylation site [posttranslational modification] 134676013012 intermolecular recognition site; other site 134676013013 dimerization interface [polypeptide binding]; other site 134676013014 Response regulator receiver domain; Region: Response_reg; pfam00072 134676013015 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676013016 active site 134676013017 phosphorylation site [posttranslational modification] 134676013018 intermolecular recognition site; other site 134676013019 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 134676013020 active site 134676013021 dimerization interface [polypeptide binding]; other site 134676013022 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 134676013023 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 134676013024 dimer interface [polypeptide binding]; other site 134676013025 phosphorylation site [posttranslational modification] 134676013026 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676013027 ATP binding site [chemical binding]; other site 134676013028 Mg2+ binding site [ion binding]; other site 134676013029 G-X-G motif; other site 134676013030 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 134676013031 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 134676013032 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 134676013033 Walker A/P-loop; other site 134676013034 ATP binding site [chemical binding]; other site 134676013035 Q-loop/lid; other site 134676013036 ABC transporter signature motif; other site 134676013037 Walker B; other site 134676013038 D-loop; other site 134676013039 H-loop/switch region; other site 134676013040 Histidine kinase; Region: HisKA_3; pfam07730 134676013041 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 134676013042 ATP binding site [chemical binding]; other site 134676013043 Mg2+ binding site [ion binding]; other site 134676013044 G-X-G motif; other site 134676013045 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 134676013046 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676013047 active site 134676013048 phosphorylation site [posttranslational modification] 134676013049 intermolecular recognition site; other site 134676013050 dimerization interface [polypeptide binding]; other site 134676013051 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 134676013052 DNA binding residues [nucleotide binding] 134676013053 dimerization interface [polypeptide binding]; other site 134676013054 Protein of unknown function (DUF2690); Region: DUF2690; pfam10901 134676013055 Transcriptional regulator [Transcription]; Region: LysR; COG0583 134676013056 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 134676013057 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 134676013058 putative dimerization interface [polypeptide binding]; other site 134676013059 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 134676013060 EamA-like transporter family; Region: EamA; pfam00892 134676013061 EamA-like transporter family; Region: EamA; pfam00892 134676013062 Domain of unknown function (DUF305); Region: DUF305; cl17794 134676013063 Chitin binding domain; Region: Chitin_bind_3; pfam03067 134676013064 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 134676013065 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 134676013066 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 134676013067 NAD(P) binding site [chemical binding]; other site 134676013068 homodimer interface [polypeptide binding]; other site 134676013069 substrate binding site [chemical binding]; other site 134676013070 active site 134676013071 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 134676013072 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 134676013073 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 134676013074 sequence-specific DNA binding site [nucleotide binding]; other site 134676013075 salt bridge; other site 134676013076 Domain of unknown function (DUF955); Region: DUF955; pfam06114 134676013077 isocitrate lyase; Provisional; Region: PRK15063 134676013078 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 134676013079 tetramer interface [polypeptide binding]; other site 134676013080 active site 134676013081 Mg2+/Mn2+ binding site [ion binding]; other site 134676013082 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 134676013083 malate synthase A; Region: malate_syn_A; TIGR01344 134676013084 active site 134676013085 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 134676013086 aromatic arch; other site 134676013087 DCoH dimer interaction site [polypeptide binding]; other site 134676013088 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 134676013089 DCoH tetramer interaction site [polypeptide binding]; other site 134676013090 substrate binding site [chemical binding]; other site 134676013091 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 134676013092 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 134676013093 Sulfatase; Region: Sulfatase; pfam00884 134676013094 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 134676013095 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 134676013096 active site 134676013097 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 134676013098 active site 134676013099 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 134676013100 Transcriptional regulators [Transcription]; Region: MarR; COG1846 134676013101 MarR family; Region: MarR_2; pfam12802 134676013102 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 134676013103 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 134676013104 active site 134676013105 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 134676013106 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 134676013107 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 134676013108 Walker A motif; other site 134676013109 ATP binding site [chemical binding]; other site 134676013110 Walker B motif; other site 134676013111 arginine finger; other site 134676013112 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 134676013113 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 134676013114 PA/protease or protease-like domain interface [polypeptide binding]; other site 134676013115 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 134676013116 Peptidase family M28; Region: Peptidase_M28; pfam04389 134676013117 active site 134676013118 metal binding site [ion binding]; metal-binding site 134676013119 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 134676013120 S-adenosylmethionine binding site [chemical binding]; other site 134676013121 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 134676013122 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 134676013123 Cellulose binding domain; Region: CBM_2; pfam00553 134676013124 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 134676013125 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 134676013126 dimerization interface [polypeptide binding]; other site 134676013127 putative DNA binding site [nucleotide binding]; other site 134676013128 putative Zn2+ binding site [ion binding]; other site 134676013129 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 134676013130 putative hydrophobic ligand binding site [chemical binding]; other site 134676013131 Protein of unknown function (DUF419); Region: DUF419; pfam04237 134676013132 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 134676013133 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 134676013134 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676013135 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 134676013136 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 134676013137 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 134676013138 intersubunit interface [polypeptide binding]; other site 134676013139 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 134676013140 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 134676013141 putative PBP binding regions; other site 134676013142 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 134676013143 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 134676013144 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 134676013145 ABC-ATPase subunit interface; other site 134676013146 dimer interface [polypeptide binding]; other site 134676013147 putative PBP binding regions; other site 134676013148 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 134676013149 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 134676013150 Walker A/P-loop; other site 134676013151 ATP binding site [chemical binding]; other site 134676013152 Q-loop/lid; other site 134676013153 ABC transporter signature motif; other site 134676013154 Walker B; other site 134676013155 D-loop; other site 134676013156 H-loop/switch region; other site 134676013157 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 134676013158 Predicted dehydrogenase [General function prediction only]; Region: COG0579 134676013159 hydroxyglutarate oxidase; Provisional; Region: PRK11728 134676013160 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 134676013161 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 134676013162 dimerization interface [polypeptide binding]; other site 134676013163 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 134676013164 dimer interface [polypeptide binding]; other site 134676013165 phosphorylation site [posttranslational modification] 134676013166 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676013167 ATP binding site [chemical binding]; other site 134676013168 Mg2+ binding site [ion binding]; other site 134676013169 G-X-G motif; other site 134676013170 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 134676013171 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676013172 active site 134676013173 phosphorylation site [posttranslational modification] 134676013174 intermolecular recognition site; other site 134676013175 dimerization interface [polypeptide binding]; other site 134676013176 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 134676013177 DNA binding site [nucleotide binding] 134676013178 FMN-binding domain; Region: FMN_bind; pfam04205 134676013179 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 134676013180 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 134676013181 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 134676013182 FAD binding pocket [chemical binding]; other site 134676013183 FAD binding motif [chemical binding]; other site 134676013184 phosphate binding motif [ion binding]; other site 134676013185 beta-alpha-beta structure motif; other site 134676013186 NAD binding pocket [chemical binding]; other site 134676013187 Transcriptional regulator [Transcription]; Region: LytR; COG1316 134676013188 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 134676013189 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676013190 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 134676013191 putative hydrophobic ligand binding site [chemical binding]; other site 134676013192 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 134676013193 dimerization interface [polypeptide binding]; other site 134676013194 putative DNA binding site [nucleotide binding]; other site 134676013195 putative Zn2+ binding site [ion binding]; other site 134676013196 Uncharacterized conserved protein [Function unknown]; Region: COG3342 134676013197 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 134676013198 Putative peptidoglycan binding domain; Region: PG_binding_2; pfam08823 134676013199 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 134676013200 active site 134676013201 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 134676013202 EAL domain; Region: EAL; pfam00563 134676013203 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 134676013204 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 134676013205 acyl-activating enzyme (AAE) consensus motif; other site 134676013206 putative AMP binding site [chemical binding]; other site 134676013207 putative active site [active] 134676013208 putative CoA binding site [chemical binding]; other site 134676013209 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 134676013210 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 134676013211 substrate binding pocket [chemical binding]; other site 134676013212 membrane-bound complex binding site; other site 134676013213 hinge residues; other site 134676013214 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 134676013215 Catalytic domain of Protein Kinases; Region: PKc; cd00180 134676013216 active site 134676013217 ATP binding site [chemical binding]; other site 134676013218 substrate binding site [chemical binding]; other site 134676013219 activation loop (A-loop); other site 134676013220 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 134676013221 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 134676013222 metal ion-dependent adhesion site (MIDAS); other site 134676013223 Double zinc ribbon; Region: DZR; pfam12773 134676013224 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 134676013225 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 134676013226 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 134676013227 phosphopeptide binding site; other site 134676013228 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 134676013229 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 134676013230 active site 134676013231 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 134676013232 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 134676013233 active site 134676013234 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 134676013235 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676013236 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 134676013237 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 134676013238 acyl-activating enzyme (AAE) consensus motif; other site 134676013239 putative AMP binding site [chemical binding]; other site 134676013240 putative active site [active] 134676013241 putative CoA binding site [chemical binding]; other site 134676013242 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 134676013243 active site 134676013244 1,4-alpha-glucan branching enzyme [Carbohydrate transport and metabolism]; Region: GlgB; COG0296 134676013245 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 134676013246 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 134676013247 catalytic site [active] 134676013248 active site 134676013249 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 134676013250 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 134676013251 anti sigma factor interaction site; other site 134676013252 regulatory phosphorylation site [posttranslational modification]; other site 134676013253 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 134676013254 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 134676013255 ATP binding site [chemical binding]; other site 134676013256 putative Mg++ binding site [ion binding]; other site 134676013257 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 134676013258 nucleotide binding region [chemical binding]; other site 134676013259 ATP-binding site [chemical binding]; other site 134676013260 rRNA-processing arch domain; Region: rRNA_proc-arch; pfam13234 134676013261 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 134676013262 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 134676013263 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 134676013264 motif II; other site 134676013265 diacylglycerol kinase; Reviewed; Region: PRK11914 134676013266 Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902 134676013267 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 134676013268 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 134676013269 Predicted transcriptional regulator [Transcription]; Region: COG2378 134676013270 WYL domain; Region: WYL; pfam13280 134676013271 Predicted transcriptional regulator [Transcription]; Region: COG2378 134676013272 WYL domain; Region: WYL; pfam13280 134676013273 Cation efflux family; Region: Cation_efflux; pfam01545 134676013274 Protein of unknown function (DUF3866); Region: DUF3866; pfam12982 134676013275 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 134676013276 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 134676013277 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 134676013278 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 134676013279 Catalytic site [active] 134676013280 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 134676013281 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676013282 metal binding site [ion binding]; metal-binding site 134676013283 active site 134676013284 I-site; other site 134676013285 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 134676013286 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 134676013287 S-adenosylmethionine binding site [chemical binding]; other site 134676013288 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 134676013289 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 134676013290 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 134676013291 active site 134676013292 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 134676013293 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 134676013294 active site 134676013295 Pup-like protein; Region: Pup; pfam05639 134676013296 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 134676013297 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 134676013298 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1; Region: Cenp-F_leu_zip; pfam10473 134676013299 proteasome ATPase; Region: pup_AAA; TIGR03689 134676013300 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 134676013301 Walker A motif; other site 134676013302 ATP binding site [chemical binding]; other site 134676013303 Walker B motif; other site 134676013304 arginine finger; other site 134676013305 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 134676013306 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 134676013307 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 134676013308 S-adenosylmethionine binding site [chemical binding]; other site 134676013309 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 134676013310 Peptidase family M50; Region: Peptidase_M50; pfam02163 134676013311 active site 134676013312 putative substrate binding region [chemical binding]; other site 134676013313 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 134676013314 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 134676013315 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 134676013316 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 134676013317 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 134676013318 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 134676013319 DNA binding residues [nucleotide binding] 134676013320 dimerization interface [polypeptide binding]; other site 134676013321 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 134676013322 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 134676013323 motif II; other site 134676013324 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 134676013325 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 134676013326 Walker A/P-loop; other site 134676013327 ATP binding site [chemical binding]; other site 134676013328 Q-loop/lid; other site 134676013329 ABC transporter signature motif; other site 134676013330 Walker B; other site 134676013331 D-loop; other site 134676013332 H-loop/switch region; other site 134676013333 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 134676013334 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 134676013335 FtsX-like permease family; Region: FtsX; pfam02687 134676013336 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 134676013337 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 134676013338 putative hydrophobic ligand binding site [chemical binding]; other site 134676013339 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 134676013340 dimerization interface [polypeptide binding]; other site 134676013341 putative DNA binding site [nucleotide binding]; other site 134676013342 putative Zn2+ binding site [ion binding]; other site 134676013343 PAC2 family; Region: PAC2; pfam09754 134676013344 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 134676013345 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 134676013346 DNA-binding site [nucleotide binding]; DNA binding site 134676013347 UTRA domain; Region: UTRA; pfam07702 134676013348 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 134676013349 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 134676013350 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 134676013351 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 134676013352 Histidine kinase; Region: HisKA_3; pfam07730 134676013353 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 134676013354 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676013355 active site 134676013356 phosphorylation site [posttranslational modification] 134676013357 intermolecular recognition site; other site 134676013358 dimerization interface [polypeptide binding]; other site 134676013359 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 134676013360 DNA binding residues [nucleotide binding] 134676013361 dimerization interface [polypeptide binding]; other site 134676013362 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 134676013363 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 134676013364 active site 134676013365 HIGH motif; other site 134676013366 nucleotide binding site [chemical binding]; other site 134676013367 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 134676013368 active site 134676013369 KMSKS motif; other site 134676013370 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 134676013371 tRNA binding surface [nucleotide binding]; other site 134676013372 anticodon binding site; other site 134676013373 conserved hypothetical protein; Region: TIGR03843 134676013374 Protein of unknown function (DUF3090); Region: DUF3090; cl12832 134676013375 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 134676013376 catalytic core [active] 134676013377 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 134676013378 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 134676013379 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 134676013380 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 134676013381 active site 134676013382 catalytic tetrad [active] 134676013383 Histidine kinase; Region: HisKA_3; pfam07730 134676013384 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 134676013385 Mg2+ binding site [ion binding]; other site 134676013386 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 134676013387 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676013388 active site 134676013389 phosphorylation site [posttranslational modification] 134676013390 intermolecular recognition site; other site 134676013391 dimerization interface [polypeptide binding]; other site 134676013392 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 134676013393 DNA binding residues [nucleotide binding] 134676013394 dimerization interface [polypeptide binding]; other site 134676013395 hypothetical protein; Provisional; Region: PRK07906 134676013396 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 134676013397 putative metal binding site [ion binding]; other site 134676013398 Hemerythrin-like domain; Region: Hr-like; cd12108 134676013399 Transcriptional regulator [Transcription]; Region: LysR; COG0583 134676013400 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 134676013401 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 134676013402 substrate binding pocket [chemical binding]; other site 134676013403 dimerization interface [polypeptide binding]; other site 134676013404 Polysaccharide lyase; Region: Polysacc_lyase; pfam14099 134676013405 Domain of unknown function (DUF4091); Region: DUF4091; pfam13320 134676013406 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 134676013407 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 134676013408 DNA binding residues [nucleotide binding] 134676013409 dimerization interface [polypeptide binding]; other site 134676013410 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 134676013411 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 134676013412 DNA binding residues [nucleotide binding] 134676013413 dimerization interface [polypeptide binding]; other site 134676013414 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 134676013415 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 134676013416 Walker A motif; other site 134676013417 ATP binding site [chemical binding]; other site 134676013418 Walker B motif; other site 134676013419 arginine finger; other site 134676013420 UvrB/uvrC motif; Region: UVR; pfam02151 134676013421 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 134676013422 Walker A motif; other site 134676013423 ATP binding site [chemical binding]; other site 134676013424 Walker B motif; other site 134676013425 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 134676013426 ribulose bisophosphate carboxylase; Reviewed; Region: rbcL; PRK04208 134676013427 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 134676013428 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 134676013429 Protein of unknown function DUF72; Region: DUF72; pfam01904 134676013430 Protein of unknown function DUF72; Region: DUF72; pfam01904 134676013431 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 134676013432 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 134676013433 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 134676013434 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 134676013435 DNA binding site [nucleotide binding] 134676013436 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 134676013437 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 134676013438 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 134676013439 nucleotide binding region [chemical binding]; other site 134676013440 ATP-binding site [chemical binding]; other site 134676013441 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 134676013442 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 134676013443 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 134676013444 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 134676013445 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 134676013446 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 134676013447 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 134676013448 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 134676013449 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 134676013450 catalytic triad [active] 134676013451 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 134676013452 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 134676013453 Walker A motif; other site 134676013454 homodimer interface [polypeptide binding]; other site 134676013455 ATP binding site [chemical binding]; other site 134676013456 hydroxycobalamin binding site [chemical binding]; other site 134676013457 Walker B motif; other site 134676013458 Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081 134676013459 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 134676013460 Mg-chelatase subunit ChlD [Coenzyme metabolism]; Region: ChlD; COG1240 134676013461 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 134676013462 metal ion-dependent adhesion site (MIDAS); other site 134676013463 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 134676013464 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 134676013465 active site 134676013466 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 134676013467 hydrophobic ligand binding site; other site 134676013468 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 134676013469 putative DNA binding site [nucleotide binding]; other site 134676013470 putative Zn2+ binding site [ion binding]; other site 134676013471 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 134676013472 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 134676013473 dimer interface [polypeptide binding]; other site 134676013474 active site 134676013475 citrylCoA binding site [chemical binding]; other site 134676013476 NADH binding [chemical binding]; other site 134676013477 cationic pore residues; other site 134676013478 oxalacetate/citrate binding site [chemical binding]; other site 134676013479 coenzyme A binding site [chemical binding]; other site 134676013480 catalytic triad [active] 134676013481 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 134676013482 Ligand Binding Site [chemical binding]; other site 134676013483 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 134676013484 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676013485 metal binding site [ion binding]; metal-binding site 134676013486 active site 134676013487 I-site; other site 134676013488 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 134676013489 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 134676013490 putative catalytic site [active] 134676013491 putative phosphate binding site [ion binding]; other site 134676013492 active site 134676013493 metal binding site A [ion binding]; metal-binding site 134676013494 DNA binding site [nucleotide binding] 134676013495 putative AP binding site [nucleotide binding]; other site 134676013496 putative metal binding site B [ion binding]; other site 134676013497 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 134676013498 B12 binding domain; Region: B12-binding_2; pfam02607 134676013499 B12 binding domain; Region: B12-binding; pfam02310 134676013500 B12 binding site [chemical binding]; other site 134676013501 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 134676013502 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 134676013503 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 134676013504 ATP binding site [chemical binding]; other site 134676013505 putative Mg++ binding site [ion binding]; other site 134676013506 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 134676013507 nucleotide binding region [chemical binding]; other site 134676013508 ATP-binding site [chemical binding]; other site 134676013509 Helicase associated domain (HA2); Region: HA2; pfam04408 134676013510 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 134676013511 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 134676013512 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 134676013513 Response regulator receiver domain; Region: Response_reg; pfam00072 134676013514 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676013515 active site 134676013516 phosphorylation site [posttranslational modification] 134676013517 intermolecular recognition site; other site 134676013518 CHASE domain; Region: CHASE; cl01369 134676013519 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 134676013520 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 134676013521 dimer interface [polypeptide binding]; other site 134676013522 phosphorylation site [posttranslational modification] 134676013523 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676013524 ATP binding site [chemical binding]; other site 134676013525 Mg2+ binding site [ion binding]; other site 134676013526 G-X-G motif; other site 134676013527 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 134676013528 PAP2 superfamily; Region: PAP2; pfam01569 134676013529 active site 134676013530 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 134676013531 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 134676013532 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 134676013533 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 134676013534 DNA binding residues [nucleotide binding] 134676013535 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 134676013536 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 134676013537 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 134676013538 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 134676013539 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 134676013540 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 134676013541 active site 134676013542 homodimer interface [polypeptide binding]; other site 134676013543 catalytic site [active] 134676013544 acceptor binding site [chemical binding]; other site 134676013545 trehalose synthase; Region: treS_nterm; TIGR02456 134676013546 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 134676013547 active site 134676013548 catalytic site [active] 134676013549 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 134676013550 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 134676013551 glycogen branching enzyme; Provisional; Region: PRK05402 134676013552 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 134676013553 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 134676013554 active site 134676013555 catalytic site [active] 134676013556 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 134676013557 Protein of unknown function (DUF4240); Region: DUF4240; pfam14024 134676013558 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 134676013559 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 134676013560 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 134676013561 active site 134676013562 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 134676013563 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 134676013564 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 134676013565 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 134676013566 RNA binding site [nucleotide binding]; other site 134676013567 Catalytic domain of Protein Kinases; Region: PKc; cd00180 134676013568 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 134676013569 active site 134676013570 ATP binding site [chemical binding]; other site 134676013571 substrate binding site [chemical binding]; other site 134676013572 activation loop (A-loop); other site 134676013573 PspC domain; Region: PspC; pfam04024 134676013574 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 134676013575 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 134676013576 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 134676013577 SLBB domain; Region: SLBB; pfam10531 134676013578 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 134676013579 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 134676013580 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 134676013581 Protein of unknown function (DUF3455); Region: DUF3455; pfam11937 134676013582 Cellulose binding domain; Region: CBM_2; pfam00553 134676013583 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 134676013584 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 134676013585 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 134676013586 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 134676013587 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 134676013588 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 134676013589 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 134676013590 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676013591 metal binding site [ion binding]; metal-binding site 134676013592 active site 134676013593 I-site; other site 134676013594 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 134676013595 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 134676013596 motif II; other site 134676013597 glycyl-tRNA synthetase; Provisional; Region: PRK14908 134676013598 glycyl-tRNA synthetase subunit alpha; Validated; Region: glyQ; PRK09348 134676013599 motif 1; other site 134676013600 dimer interface [polypeptide binding]; other site 134676013601 active site 134676013602 motif 2; other site 134676013603 motif 3; other site 134676013604 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 134676013605 Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067 134676013606 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 134676013607 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676013608 active site 134676013609 phosphorylation site [posttranslational modification] 134676013610 intermolecular recognition site; other site 134676013611 dimerization interface [polypeptide binding]; other site 134676013612 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 134676013613 DNA binding residues [nucleotide binding] 134676013614 dimerization interface [polypeptide binding]; other site 134676013615 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 134676013616 Histidine kinase; Region: HisKA_3; pfam07730 134676013617 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676013618 ATP binding site [chemical binding]; other site 134676013619 Mg2+ binding site [ion binding]; other site 134676013620 G-X-G motif; other site 134676013621 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 134676013622 Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602 134676013623 putative active site [active] 134676013624 catalytic site [active] 134676013625 putative metal binding site [ion binding]; other site 134676013626 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 134676013627 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 134676013628 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676013629 metal binding site [ion binding]; metal-binding site 134676013630 active site 134676013631 I-site; other site 134676013632 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 134676013633 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 134676013634 PAS domain; Region: PAS_9; pfam13426 134676013635 putative active site [active] 134676013636 heme pocket [chemical binding]; other site 134676013637 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 134676013638 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676013639 metal binding site [ion binding]; metal-binding site 134676013640 active site 134676013641 I-site; other site 134676013642 Transcriptional regulators [Transcription]; Region: PurR; COG1609 134676013643 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 134676013644 DNA binding site [nucleotide binding] 134676013645 domain linker motif; other site 134676013646 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 134676013647 putative dimerization interface [polypeptide binding]; other site 134676013648 putative ligand binding site [chemical binding]; other site 134676013649 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 134676013650 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 134676013651 conserved cys residue [active] 134676013652 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 134676013653 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 134676013654 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 134676013655 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 134676013656 Transcriptional regulators [Transcription]; Region: PurR; COG1609 134676013657 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 134676013658 DNA binding site [nucleotide binding] 134676013659 domain linker motif; other site 134676013660 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 134676013661 ligand binding site [chemical binding]; other site 134676013662 dimerization interface [polypeptide binding]; other site 134676013663 Amb_all domain; Region: Amb_all; smart00656 134676013664 Cupin domain; Region: Cupin_2; pfam07883 134676013665 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 134676013666 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 134676013667 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 134676013668 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 134676013669 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 134676013670 glucuronate isomerase; Reviewed; Region: PRK02925 134676013671 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 134676013672 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 134676013673 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 134676013674 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 134676013675 Transcriptional regulators [Transcription]; Region: PurR; COG1609 134676013676 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 134676013677 DNA binding site [nucleotide binding] 134676013678 domain linker motif; other site 134676013679 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 134676013680 dimerization interface [polypeptide binding]; other site 134676013681 ligand binding site [chemical binding]; other site 134676013682 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 134676013683 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 134676013684 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 134676013685 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 134676013686 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 134676013687 putative PBP binding loops; other site 134676013688 dimer interface [polypeptide binding]; other site 134676013689 ABC-ATPase subunit interface; other site 134676013690 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 134676013691 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 134676013692 dimer interface [polypeptide binding]; other site 134676013693 conserved gate region; other site 134676013694 putative PBP binding loops; other site 134676013695 ABC-ATPase subunit interface; other site 134676013696 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 134676013697 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 134676013698 putative DNA binding site [nucleotide binding]; other site 134676013699 putative Zn2+ binding site [ion binding]; other site 134676013700 AsnC family; Region: AsnC_trans_reg; pfam01037 134676013701 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 134676013702 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 134676013703 hexamer interface [polypeptide binding]; other site 134676013704 ligand binding site [chemical binding]; other site 134676013705 putative active site [active] 134676013706 NAD(P) binding site [chemical binding]; other site 134676013707 phosphate transporter ATP-binding protein; Provisional; Region: PRK14236 134676013708 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 134676013709 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676013710 active site 134676013711 phosphorylation site [posttranslational modification] 134676013712 intermolecular recognition site; other site 134676013713 dimerization interface [polypeptide binding]; other site 134676013714 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 134676013715 dimerization interface [polypeptide binding]; other site 134676013716 DNA binding residues [nucleotide binding] 134676013717 Histidine kinase; Region: HisKA_3; pfam07730 134676013718 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 134676013719 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 134676013720 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 134676013721 FAD binding pocket [chemical binding]; other site 134676013722 FAD binding motif [chemical binding]; other site 134676013723 phosphate binding motif [ion binding]; other site 134676013724 beta-alpha-beta structure motif; other site 134676013725 NAD binding pocket [chemical binding]; other site 134676013726 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 134676013727 catalytic loop [active] 134676013728 iron binding site [ion binding]; other site 134676013729 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 134676013730 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 134676013731 putative di-iron ligands [ion binding]; other site 134676013732 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 134676013733 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 134676013734 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 134676013735 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 134676013736 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 134676013737 NAD(P) binding site [chemical binding]; other site 134676013738 LDH/MDH dimer interface [polypeptide binding]; other site 134676013739 substrate binding site [chemical binding]; other site 134676013740 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 134676013741 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 134676013742 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 134676013743 dimer interface [polypeptide binding]; other site 134676013744 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 134676013745 conserved gate region; other site 134676013746 putative PBP binding loops; other site 134676013747 ABC-ATPase subunit interface; other site 134676013748 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 134676013749 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 134676013750 ABC-ATPase subunit interface; other site 134676013751 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 134676013752 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 134676013753 substrate binding site [chemical binding]; other site 134676013754 ATP binding site [chemical binding]; other site 134676013755 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 134676013756 GAF domain; Region: GAF; pfam01590 134676013757 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 134676013758 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 134676013759 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 134676013760 dimerization interface [polypeptide binding]; other site 134676013761 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 134676013762 putative CheW interface [polypeptide binding]; other site 134676013763 TIGR02452 family protein; Region: TIGR02452 134676013764 Uncharacterized protein conserved in bacteria (DUF2263); Region: DUF2263; pfam10021 134676013765 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 134676013766 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 134676013767 FAD binding pocket [chemical binding]; other site 134676013768 FAD binding motif [chemical binding]; other site 134676013769 phosphate binding motif [ion binding]; other site 134676013770 beta-alpha-beta structure motif; other site 134676013771 NAD binding pocket [chemical binding]; other site 134676013772 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 134676013773 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 134676013774 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 134676013775 DNA binding residues [nucleotide binding] 134676013776 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 134676013777 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 134676013778 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 134676013779 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 134676013780 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 134676013781 Short C-terminal domain; Region: SHOCT; pfam09851 134676013782 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 134676013783 nucleotide binding site/active site [active] 134676013784 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 134676013785 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 134676013786 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 134676013787 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 134676013788 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 134676013789 dimer interface [polypeptide binding]; other site 134676013790 conserved gate region; other site 134676013791 putative PBP binding loops; other site 134676013792 ABC-ATPase subunit interface; other site 134676013793 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 134676013794 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 134676013795 dimer interface [polypeptide binding]; other site 134676013796 conserved gate region; other site 134676013797 putative PBP binding loops; other site 134676013798 ABC-ATPase subunit interface; other site 134676013799 Transcriptional regulators [Transcription]; Region: PurR; COG1609 134676013800 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 134676013801 DNA binding site [nucleotide binding] 134676013802 domain linker motif; other site 134676013803 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 134676013804 putative dimerization interface [polypeptide binding]; other site 134676013805 putative ligand binding site [chemical binding]; other site 134676013806 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 134676013807 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 134676013808 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 134676013809 Predicted transcriptional regulators [Transcription]; Region: COG1695 134676013810 MMPL family; Region: MMPL; pfam03176 134676013811 MMPL family; Region: MMPL; pfam03176 134676013812 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 134676013813 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676013814 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 134676013815 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 134676013816 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 134676013817 active site 134676013818 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cd00110 134676013819 L-arabinose isomerase; Provisional; Region: PRK02929 134676013820 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 134676013821 hexamer (dimer of trimers) interface [polypeptide binding]; other site 134676013822 trimer interface [polypeptide binding]; other site 134676013823 substrate binding site [chemical binding]; other site 134676013824 Mn binding site [ion binding]; other site 134676013825 Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components [Carbohydrate transport and metabolism]; Region: AraH; COG1172 134676013826 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 134676013827 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 134676013828 TM-ABC transporter signature motif; other site 134676013829 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 134676013830 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 134676013831 TM-ABC transporter signature motif; other site 134676013832 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 134676013833 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 134676013834 Walker A/P-loop; other site 134676013835 ATP binding site [chemical binding]; other site 134676013836 Q-loop/lid; other site 134676013837 ABC transporter signature motif; other site 134676013838 Walker B; other site 134676013839 D-loop; other site 134676013840 H-loop/switch region; other site 134676013841 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 134676013842 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 134676013843 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 134676013844 putative ligand binding site [chemical binding]; other site 134676013845 Transcriptional regulators [Transcription]; Region: PurR; COG1609 134676013846 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 134676013847 DNA binding site [nucleotide binding] 134676013848 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 134676013849 ligand binding site [chemical binding]; other site 134676013850 dimerization interface (open form) [polypeptide binding]; other site 134676013851 dimerization interface (closed form) [polypeptide binding]; other site 134676013852 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 134676013853 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 134676013854 intersubunit interface [polypeptide binding]; other site 134676013855 active site 134676013856 Zn2+ binding site [ion binding]; other site 134676013857 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 134676013858 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 134676013859 Part of AAA domain; Region: AAA_19; pfam13245 134676013860 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 134676013861 AAA domain; Region: AAA_12; pfam13087 134676013862 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 134676013863 putative active site [active] 134676013864 HIRAN domain; Region: HIRAN; cl07418 134676013865 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 134676013866 Prostaglandin dehydrogenases; Region: PGDH; cd05288 134676013867 NAD(P) binding site [chemical binding]; other site 134676013868 substrate binding site [chemical binding]; other site 134676013869 dimer interface [polypeptide binding]; other site 134676013870 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 134676013871 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676013872 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 134676013873 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 134676013874 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 134676013875 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676013876 ATP binding site [chemical binding]; other site 134676013877 Mg2+ binding site [ion binding]; other site 134676013878 G-X-G motif; other site 134676013879 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 134676013880 dimer interface [polypeptide binding]; other site 134676013881 putative CheW interface [polypeptide binding]; other site 134676013882 PilZ domain; Region: PilZ; pfam07238 134676013883 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 134676013884 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676013885 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 134676013886 ABC-2 type transporter; Region: ABC2_membrane; cl17235 134676013887 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 134676013888 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 134676013889 Walker A/P-loop; other site 134676013890 ATP binding site [chemical binding]; other site 134676013891 Q-loop/lid; other site 134676013892 ABC transporter signature motif; other site 134676013893 Walker B; other site 134676013894 D-loop; other site 134676013895 H-loop/switch region; other site 134676013896 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 134676013897 active site 134676013898 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 134676013899 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 134676013900 GAF domain; Region: GAF; cl17456 134676013901 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 134676013902 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 134676013903 anti sigma factor interaction site; other site 134676013904 regulatory phosphorylation site [posttranslational modification]; other site 134676013905 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 134676013906 GAF domain; Region: GAF; pfam01590 134676013907 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 134676013908 Protease prsW family; Region: PrsW-protease; pfam13367 134676013909 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 134676013910 putative catalytic site [active] 134676013911 putative metal binding site [ion binding]; other site 134676013912 putative phosphate binding site [ion binding]; other site 134676013913 Jacalin-like lectin domains of putative endonucleases/exonucleases/phosphatases and related proteins; Region: Jacalin_EEP; cd09615 134676013914 putative sugar binding site [chemical binding]; other site 134676013915 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 134676013916 active site 134676013917 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 134676013918 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 134676013919 Transcriptional regulator [Transcription]; Region: LysR; COG0583 134676013920 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 134676013921 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 134676013922 putative dimerization interface [polypeptide binding]; other site 134676013923 Proline dehydrogenase; Region: Pro_dh; cl03282 134676013924 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 134676013925 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 134676013926 NAD(P) binding site [chemical binding]; other site 134676013927 catalytic residues [active] 134676013928 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 134676013929 TIGR03086 family protein; Region: TIGR03086 134676013930 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 134676013931 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 134676013932 motif II; other site 134676013933 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 134676013934 hypothetical protein; Validated; Region: PRK06201 134676013935 Protein of unknown function (DUF2804); Region: DUF2804; pfam10974 134676013936 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 134676013937 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 134676013938 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 134676013939 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 134676013940 AAA domain; Region: AAA_30; pfam13604 134676013941 Family description; Region: UvrD_C_2; pfam13538 134676013942 Domain of unknown function (DUF4360); Region: DUF4360; pfam14273 134676013943 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 134676013944 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 134676013945 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 134676013946 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 134676013947 dimer interface [polypeptide binding]; other site 134676013948 putative CheW interface [polypeptide binding]; other site 134676013949 DAK2 domain; Region: Dak2; cl03685 134676013950 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 134676013951 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 134676013952 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 134676013953 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206 134676013954 dimerization domain swap beta strand [polypeptide binding]; other site 134676013955 regulatory protein interface [polypeptide binding]; other site 134676013956 active site 134676013957 regulatory phosphorylation site [posttranslational modification]; other site 134676013958 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 134676013959 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 134676013960 active site 134676013961 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 134676013962 Predicted membrane protein [Function unknown]; Region: COG4682 134676013963 yiaA/B two helix domain; Region: YiaAB; cl01759 134676013964 yiaA/B two helix domain; Region: YiaAB; pfam05360 134676013965 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 134676013966 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 134676013967 dimer interface [polypeptide binding]; other site 134676013968 active site 134676013969 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 134676013970 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 134676013971 NAD(P) binding site [chemical binding]; other site 134676013972 active site 134676013973 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 134676013974 active site 1 [active] 134676013975 Domain of unknown function (DUF385); Region: DUF385; cl04387 134676013976 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 134676013977 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 134676013978 NAD(P) binding site [chemical binding]; other site 134676013979 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 134676013980 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676013981 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676013982 PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398 134676013983 active site 134676013984 acyl-CoA synthetase; Validated; Region: PRK07788 134676013985 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 134676013986 acyl-activating enzyme (AAE) consensus motif; other site 134676013987 AMP binding site [chemical binding]; other site 134676013988 active site 134676013989 CoA binding site [chemical binding]; other site 134676013990 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 134676013991 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 134676013992 active site 134676013993 Protein of unknown function (DUF2927); Region: DUF2927; pfam11150 134676013994 SnoaL-like domain; Region: SnoaL_4; pfam13577 134676013995 Excalibur calcium-binding domain; Region: Excalibur; cl05460 134676013996 Excalibur calcium-binding domain; Region: Excalibur; smart00894 134676013997 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 134676013998 Part of AAA domain; Region: AAA_19; pfam13245 134676013999 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 134676014000 AAA domain; Region: AAA_12; pfam13087 134676014001 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 134676014002 putative active site [active] 134676014003 Protein of unknown function (DUF3320); Region: DUF3320; pfam11784 134676014004 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 134676014005 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 134676014006 Methyltransferase domain; Region: Methyltransf_23; pfam13489 134676014007 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 134676014008 S-adenosylmethionine binding site [chemical binding]; other site 134676014009 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 134676014010 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 134676014011 non-specific DNA binding site [nucleotide binding]; other site 134676014012 salt bridge; other site 134676014013 sequence-specific DNA binding site [nucleotide binding]; other site 134676014014 Cupin domain; Region: Cupin_2; pfam07883 134676014015 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 134676014016 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 134676014017 NAD binding site [chemical binding]; other site 134676014018 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 134676014019 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 134676014020 dimer interface [polypeptide binding]; other site 134676014021 phosphorylation site [posttranslational modification] 134676014022 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676014023 Mg2+ binding site [ion binding]; other site 134676014024 G-X-G motif; other site 134676014025 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 134676014026 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 134676014027 substrate binding site [chemical binding]; other site 134676014028 oxyanion hole (OAH) forming residues; other site 134676014029 trimer interface [polypeptide binding]; other site 134676014030 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 134676014031 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; smart00813 134676014032 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 134676014033 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 134676014034 active site 134676014035 PAS domain; Region: PAS_9; pfam13426 134676014036 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 134676014037 putative active site [active] 134676014038 heme pocket [chemical binding]; other site 134676014039 PAS fold; Region: PAS_4; pfam08448 134676014040 PAS domain S-box; Region: sensory_box; TIGR00229 134676014041 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 134676014042 putative active site [active] 134676014043 heme pocket [chemical binding]; other site 134676014044 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676014045 metal binding site [ion binding]; metal-binding site 134676014046 active site 134676014047 I-site; other site 134676014048 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 134676014049 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 134676014050 adenosine deaminase; Provisional; Region: PRK09358 134676014051 active site 134676014052 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 134676014053 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 134676014054 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 134676014055 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 134676014056 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 134676014057 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 134676014058 NAD-dependent deacetylase; Provisional; Region: PRK00481 134676014059 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 134676014060 NAD+ binding site [chemical binding]; other site 134676014061 substrate binding site [chemical binding]; other site 134676014062 Zn binding site [ion binding]; other site 134676014063 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 134676014064 putative active site [active] 134676014065 putative catalytic site [active] 134676014066 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 134676014067 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676014068 metal binding site [ion binding]; metal-binding site 134676014069 active site 134676014070 I-site; other site 134676014071 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 134676014072 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 134676014073 Major Facilitator Superfamily; Region: MFS_1; pfam07690 134676014074 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 134676014075 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 134676014076 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676014077 Transglycosylase; Region: Transgly; pfam00912 134676014078 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 134676014079 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 134676014080 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 134676014081 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 134676014082 Part of AAA domain; Region: AAA_19; pfam13245 134676014083 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 134676014084 AAA domain; Region: AAA_12; pfam13087 134676014085 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 134676014086 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 134676014087 NAD(P) binding site [chemical binding]; other site 134676014088 homodimer interface [polypeptide binding]; other site 134676014089 substrate binding site [chemical binding]; other site 134676014090 active site 134676014091 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 134676014092 Chain length determinant protein; Region: Wzz; pfam02706 134676014093 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 134676014094 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 134676014095 Nucleotide binding site [chemical binding]; other site 134676014096 P loop; other site 134676014097 DTAP/Switch II; other site 134676014098 Switch I; other site 134676014099 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 134676014100 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 134676014101 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 134676014102 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 134676014103 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 134676014104 putative trimer interface [polypeptide binding]; other site 134676014105 putative CoA binding site [chemical binding]; other site 134676014106 Bacterial sugar transferase; Region: Bac_transf; pfam02397 134676014107 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 134676014108 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 134676014109 inhibitor-cofactor binding pocket; inhibition site 134676014110 pyridoxal 5'-phosphate binding site [chemical binding]; other site 134676014111 catalytic residue [active] 134676014112 LexA repressor; Validated; Region: PRK00215 134676014113 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 134676014114 putative DNA binding site [nucleotide binding]; other site 134676014115 putative Zn2+ binding site [ion binding]; other site 134676014116 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 134676014117 Catalytic site [active] 134676014118 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 134676014119 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 134676014120 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 134676014121 replicative DNA helicase; Provisional; Region: PRK05973 134676014122 thymidine kinase; Provisional; Region: PRK04296 134676014123 Staphylococcal nuclease homologues; Region: SNc; smart00318 134676014124 Lamin Tail Domain; Region: LTD; pfam00932 134676014125 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 134676014126 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 134676014127 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 134676014128 Walker A/P-loop; other site 134676014129 ATP binding site [chemical binding]; other site 134676014130 Q-loop/lid; other site 134676014131 ABC transporter signature motif; other site 134676014132 Walker B; other site 134676014133 D-loop; other site 134676014134 H-loop/switch region; other site 134676014135 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 134676014136 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 134676014137 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 134676014138 Walker A/P-loop; other site 134676014139 ATP binding site [chemical binding]; other site 134676014140 Q-loop/lid; other site 134676014141 ABC transporter signature motif; other site 134676014142 Walker B; other site 134676014143 D-loop; other site 134676014144 H-loop/switch region; other site 134676014145 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 134676014146 Beta-lactamase; Region: Beta-lactamase; pfam00144 134676014147 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 134676014148 putative catalytic site [active] 134676014149 putative metal binding site [ion binding]; other site 134676014150 putative phosphate binding site [ion binding]; other site 134676014151 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 134676014152 tetramer interface [polypeptide binding]; other site 134676014153 active site 134676014154 Mg2+/Mn2+ binding site [ion binding]; other site 134676014155 hypothetical protein; Provisional; Region: PRK06834 134676014156 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 134676014157 hydroxyglutarate oxidase; Provisional; Region: PRK11728 134676014158 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 134676014159 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 134676014160 ADP-ribose binding site [chemical binding]; other site 134676014161 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 134676014162 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 134676014163 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 134676014164 active site 134676014165 Protein of unknown function (DUF1211); Region: DUF1211; pfam06736 134676014166 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 134676014167 active site 134676014168 Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506 134676014169 C-terminal Early set domain associated with the catalytic domain of galactose oxidase; Region: E_set_GO_C; cd02851 134676014170 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 134676014171 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 134676014172 Walker A/P-loop; other site 134676014173 ATP binding site [chemical binding]; other site 134676014174 Q-loop/lid; other site 134676014175 ABC transporter signature motif; other site 134676014176 Walker B; other site 134676014177 D-loop; other site 134676014178 H-loop/switch region; other site 134676014179 ABC-2 type transporter; Region: ABC2_membrane; cl17235 134676014180 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 134676014181 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 134676014182 Predicted ATPase [General function prediction only]; Region: COG3903 134676014183 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 134676014184 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 134676014185 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676014186 metal binding site [ion binding]; metal-binding site 134676014187 active site 134676014188 I-site; other site 134676014189 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 134676014190 Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270 134676014191 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 134676014192 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 134676014193 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 134676014194 PBP superfamily domain; Region: PBP_like_2; cl17296 134676014195 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 134676014196 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 134676014197 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 134676014198 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 134676014199 putative PBP binding loops; other site 134676014200 dimer interface [polypeptide binding]; other site 134676014201 ABC-ATPase subunit interface; other site 134676014202 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 134676014203 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 134676014204 dimer interface [polypeptide binding]; other site 134676014205 conserved gate region; other site 134676014206 putative PBP binding loops; other site 134676014207 ABC-ATPase subunit interface; other site 134676014208 Transcriptional regulators [Transcription]; Region: PurR; COG1609 134676014209 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 134676014210 DNA binding site [nucleotide binding] 134676014211 domain linker motif; other site 134676014212 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 134676014213 ligand binding site [chemical binding]; other site 134676014214 dimerization interface (open form) [polypeptide binding]; other site 134676014215 dimerization interface (closed form) [polypeptide binding]; other site 134676014216 Predicted transcriptional regulators [Transcription]; Region: COG1695 134676014217 Transcriptional regulator PadR-like family; Region: PadR; cl17335 134676014218 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 134676014219 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 134676014220 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 134676014221 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 134676014222 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 134676014223 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 134676014224 DNA binding residues [nucleotide binding] 134676014225 Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224 134676014226 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 134676014227 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 134676014228 short chain dehydrogenase; Provisional; Region: PRK06181 134676014229 classical (c) SDRs; Region: SDR_c; cd05233 134676014230 NAD(P) binding site [chemical binding]; other site 134676014231 active site 134676014232 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 134676014233 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676014234 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 134676014235 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 134676014236 metal-binding site [ion binding] 134676014237 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 134676014238 Soluble P-type ATPase [General function prediction only]; Region: COG4087 134676014239 elongation factor Tu; Reviewed; Region: PRK12736 134676014240 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 134676014241 G1 box; other site 134676014242 GEF interaction site [polypeptide binding]; other site 134676014243 GTP/Mg2+ binding site [chemical binding]; other site 134676014244 Switch I region; other site 134676014245 G2 box; other site 134676014246 G3 box; other site 134676014247 Switch II region; other site 134676014248 G4 box; other site 134676014249 G5 box; other site 134676014250 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 134676014251 Domain III of Elongation factor (EF) Tu (EF-TU) and EF-G. Elongation factors (EF) EF-Tu and EF-G participate in the elongation phase during protein biosynthesis on the ribosome. Their functional cycles depend on GTP binding and its hydrolysis. The EF-Tu...; Region: Translation_factor_III; cl02786 134676014252 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 134676014253 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 134676014254 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 134676014255 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 134676014256 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 134676014257 active site 134676014258 catalytic site [active] 134676014259 substrate binding site [chemical binding]; other site 134676014260 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 134676014261 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 134676014262 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 134676014263 Walker A/P-loop; other site 134676014264 ATP binding site [chemical binding]; other site 134676014265 Q-loop/lid; other site 134676014266 ABC transporter signature motif; other site 134676014267 Walker B; other site 134676014268 D-loop; other site 134676014269 H-loop/switch region; other site 134676014270 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 134676014271 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 134676014272 Walker A/P-loop; other site 134676014273 ATP binding site [chemical binding]; other site 134676014274 Q-loop/lid; other site 134676014275 ABC transporter signature motif; other site 134676014276 Walker B; other site 134676014277 D-loop; other site 134676014278 H-loop/switch region; other site 134676014279 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 134676014280 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 134676014281 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 134676014282 dimer interface [polypeptide binding]; other site 134676014283 conserved gate region; other site 134676014284 putative PBP binding loops; other site 134676014285 ABC-ATPase subunit interface; other site 134676014286 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 134676014287 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 134676014288 dimer interface [polypeptide binding]; other site 134676014289 conserved gate region; other site 134676014290 putative PBP binding loops; other site 134676014291 ABC-ATPase subunit interface; other site 134676014292 The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506 134676014293 peptide binding site [polypeptide binding]; other site 134676014294 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 134676014295 SnoaL-like domain; Region: SnoaL_2; pfam12680 134676014296 Domain of unknown function (DUF4360); Region: DUF4360; pfam14273 134676014297 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 134676014298 CopC domain; Region: CopC; pfam04234 134676014299 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 134676014300 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 134676014301 Ferredoxin [Energy production and conversion]; Region: COG1146 134676014302 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 134676014303 Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_euk_AmyA; cd11317 134676014304 active site 134676014305 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 134676014306 Ca binding site [ion binding]; other site 134676014307 catalytic site [active] 134676014308 Aamy_C domain; Region: Aamy_C; smart00632 134676014309 Starch binding domain; Region: CBM_20; pfam00686 134676014310 starch-binding site 2 [chemical binding]; other site 134676014311 starch-binding site 1 [chemical binding]; other site 134676014312 The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cl15347 134676014313 starch-binding site 2 [chemical binding]; other site 134676014314 starch-binding site 1 [chemical binding]; other site 134676014315 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 134676014316 active site 134676014317 catalytic triad [active] 134676014318 oxyanion hole [active] 134676014319 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 134676014320 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676014321 Methyltransferase domain; Region: Methyltransf_23; pfam13489 134676014322 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 134676014323 S-adenosylmethionine binding site [chemical binding]; other site 134676014324 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 134676014325 glycerol kinase; Provisional; Region: glpK; PRK00047 134676014326 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 134676014327 N- and C-terminal domain interface [polypeptide binding]; other site 134676014328 active site 134676014329 MgATP binding site [chemical binding]; other site 134676014330 catalytic site [active] 134676014331 metal binding site [ion binding]; metal-binding site 134676014332 putative homotetramer interface [polypeptide binding]; other site 134676014333 glycerol binding site [chemical binding]; other site 134676014334 homodimer interface [polypeptide binding]; other site 134676014335 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 134676014336 amphipathic channel; other site 134676014337 Asn-Pro-Ala signature motifs; other site 134676014338 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 134676014339 Transcriptional regulator [Transcription]; Region: IclR; COG1414 134676014340 Bacterial transcriptional regulator; Region: IclR; pfam01614 134676014341 glycerol kinase; Provisional; Region: glpK; PRK00047 134676014342 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 134676014343 nucleotide binding site [chemical binding]; other site 134676014344 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 134676014345 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 134676014346 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 134676014347 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 134676014348 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 134676014349 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 134676014350 putative active site [active] 134676014351 putative metal binding site [ion binding]; other site 134676014352 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 134676014353 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 134676014354 inhibitor-cofactor binding pocket; inhibition site 134676014355 pyridoxal 5'-phosphate binding site [chemical binding]; other site 134676014356 catalytic residue [active] 134676014357 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 134676014358 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 134676014359 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 134676014360 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 134676014361 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 134676014362 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 134676014363 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 134676014364 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 134676014365 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 134676014366 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676014367 metal binding site [ion binding]; metal-binding site 134676014368 active site 134676014369 I-site; other site 134676014370 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 134676014371 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 134676014372 MOSC domain; Region: MOSC; pfam03473 134676014373 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 134676014374 FOG: WD40 repeat [General function prediction only]; Region: COG2319 134676014375 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 134676014376 Coenzyme A binding pocket [chemical binding]; other site 134676014377 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 134676014378 Bacterial sugar transferase; Region: Bac_transf; pfam02397 134676014379 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721 134676014380 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 134676014381 NAD(P) binding site [chemical binding]; other site 134676014382 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 134676014383 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 134676014384 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 134676014385 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 134676014386 NAD(P) binding site [chemical binding]; other site 134676014387 homodimer interface [polypeptide binding]; other site 134676014388 substrate binding site [chemical binding]; other site 134676014389 active site 134676014390 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 134676014391 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 134676014392 VanZ like family; Region: VanZ; pfam04892 134676014393 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 134676014394 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 134676014395 DNA binding residues [nucleotide binding] 134676014396 dimerization interface [polypeptide binding]; other site 134676014397 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 134676014398 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 134676014399 putative substrate translocation pore; other site 134676014400 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 134676014401 elongation factor G; Reviewed; Region: PRK13351 134676014402 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 134676014403 G1 box; other site 134676014404 putative GEF interaction site [polypeptide binding]; other site 134676014405 GTP/Mg2+ binding site [chemical binding]; other site 134676014406 Switch I region; other site 134676014407 G2 box; other site 134676014408 G3 box; other site 134676014409 Switch II region; other site 134676014410 G4 box; other site 134676014411 G5 box; other site 134676014412 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 134676014413 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 134676014414 Elongation factor G C-terminus. This domain includes the carboxyl terminal regions of elongation factors (EFs) bacterial EF-G, eukaryotic and archeal EF-2 and eukaryotic mitochondrial mtEFG1s and mtEFG2s. This group also includes proteins similar to the...; Region: Elongation_Factor_C; cd01514 134676014415 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 134676014416 Histidine kinase; Region: HisKA_3; pfam07730 134676014417 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676014418 ATP binding site [chemical binding]; other site 134676014419 Mg2+ binding site [ion binding]; other site 134676014420 G-X-G motif; other site 134676014421 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 134676014422 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676014423 active site 134676014424 phosphorylation site [posttranslational modification] 134676014425 intermolecular recognition site; other site 134676014426 dimerization interface [polypeptide binding]; other site 134676014427 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 134676014428 DNA binding residues [nucleotide binding] 134676014429 dimerization interface [polypeptide binding]; other site 134676014430 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 134676014431 beta-galactosidase; Region: BGL; TIGR03356 134676014432 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 134676014433 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 134676014434 dimer interface [polypeptide binding]; other site 134676014435 conserved gate region; other site 134676014436 putative PBP binding loops; other site 134676014437 ABC-ATPase subunit interface; other site 134676014438 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 134676014439 dimer interface [polypeptide binding]; other site 134676014440 conserved gate region; other site 134676014441 putative PBP binding loops; other site 134676014442 ABC-ATPase subunit interface; other site 134676014443 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 134676014444 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 134676014445 Transcriptional regulators [Transcription]; Region: PurR; COG1609 134676014446 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 134676014447 DNA binding site [nucleotide binding] 134676014448 domain linker motif; other site 134676014449 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 134676014450 ligand binding site [chemical binding]; other site 134676014451 dimerization interface [polypeptide binding]; other site 134676014452 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 134676014453 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 134676014454 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 134676014455 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676014456 YhhN-like protein; Region: YhhN; pfam07947 134676014457 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 134676014458 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 134676014459 Transcriptional regulators [Transcription]; Region: FadR; COG2186 134676014460 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 134676014461 DNA-binding site [nucleotide binding]; DNA binding site 134676014462 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 134676014463 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676014464 metal binding site [ion binding]; metal-binding site 134676014465 active site 134676014466 I-site; other site 134676014467 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 134676014468 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 134676014469 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 134676014470 Walker A/P-loop; other site 134676014471 ATP binding site [chemical binding]; other site 134676014472 Q-loop/lid; other site 134676014473 ABC transporter signature motif; other site 134676014474 Walker B; other site 134676014475 D-loop; other site 134676014476 H-loop/switch region; other site 134676014477 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 134676014478 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 134676014479 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 134676014480 Predicted ATPase [General function prediction only]; Region: COG3903 134676014481 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 134676014482 Phosphoesterase family; Region: Phosphoesterase; pfam04185 134676014483 Domain of unknown function (DUF756); Region: DUF756; pfam05506 134676014484 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 134676014485 nudix motif; other site 134676014486 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 134676014487 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 134676014488 PRC-barrel domain; Region: PRC; pfam05239 134676014489 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 134676014490 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 134676014491 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 134676014492 Walker A/P-loop; other site 134676014493 ATP binding site [chemical binding]; other site 134676014494 Q-loop/lid; other site 134676014495 ABC transporter signature motif; other site 134676014496 Walker B; other site 134676014497 D-loop; other site 134676014498 H-loop/switch region; other site 134676014499 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 134676014500 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 134676014501 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 134676014502 ABC transporter signature motif; other site 134676014503 Walker B; other site 134676014504 D-loop; other site 134676014505 H-loop/switch region; other site 134676014506 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 134676014507 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 134676014508 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676014509 active site 134676014510 phosphorylation site [posttranslational modification] 134676014511 intermolecular recognition site; other site 134676014512 dimerization interface [polypeptide binding]; other site 134676014513 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 134676014514 DNA binding site [nucleotide binding] 134676014515 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 134676014516 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 134676014517 dimerization interface [polypeptide binding]; other site 134676014518 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 134676014519 dimer interface [polypeptide binding]; other site 134676014520 phosphorylation site [posttranslational modification] 134676014521 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676014522 ATP binding site [chemical binding]; other site 134676014523 Mg2+ binding site [ion binding]; other site 134676014524 G-X-G motif; other site 134676014525 Predicted transcriptional regulators [Transcription]; Region: COG1695 134676014526 Transcriptional regulator PadR-like family; Region: PadR; cl17335 134676014527 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 134676014528 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676014529 active site 134676014530 phosphorylation site [posttranslational modification] 134676014531 intermolecular recognition site; other site 134676014532 dimerization interface [polypeptide binding]; other site 134676014533 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 134676014534 DNA binding residues [nucleotide binding] 134676014535 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 134676014536 Histidine kinase; Region: HisKA_3; pfam07730 134676014537 Lipase (class 2); Region: Lipase_2; pfam01674 134676014538 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 134676014539 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 134676014540 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 134676014541 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 134676014542 Walker A/P-loop; other site 134676014543 ATP binding site [chemical binding]; other site 134676014544 Q-loop/lid; other site 134676014545 ABC transporter signature motif; other site 134676014546 Walker B; other site 134676014547 D-loop; other site 134676014548 H-loop/switch region; other site 134676014549 FAD binding domain; Region: FAD_binding_3; pfam01494 134676014550 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 134676014551 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 134676014552 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676014553 Domain of unknown function (DUF385); Region: DUF385; cl04387 134676014554 LGFP repeat; Region: LGFP; pfam08310 134676014555 LGFP repeat; Region: LGFP; pfam08310 134676014556 Protein tyrosine kinase; Region: Pkinase_Tyr; pfam07714 134676014557 Catalytic domain of Protein Kinases; Region: PKc; cd00180 134676014558 active site 134676014559 ATP binding site [chemical binding]; other site 134676014560 substrate binding site [chemical binding]; other site 134676014561 activation loop (A-loop); other site 134676014562 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 134676014563 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676014564 metal binding site [ion binding]; metal-binding site 134676014565 active site 134676014566 I-site; other site 134676014567 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 134676014568 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 134676014569 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 134676014570 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 134676014571 Beta-galactosidase, domain 2; Region: BetaGal_dom2; smart01029 134676014572 Beta-galactosidase, domain 2; Region: BetaGal_dom2; pfam10435 134676014573 Beta-galactosidase, domain 3; Region: BetaGal_dom3; pfam13363 134676014574 Beta-galactosidase jelly roll domain; Region: BetaGal_dom4_5; pfam13364 134676014575 Beta-galactosidase jelly roll domain; Region: BetaGal_dom4_5; pfam13364 134676014576 putative pectinesterase; Region: PLN02432; cl01911 134676014577 Pectinesterase; Region: Pectinesterase; pfam01095 134676014578 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 134676014579 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676014580 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 134676014581 Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297 134676014582 putative metal binding site [ion binding]; other site 134676014583 Uncharacterized conserved protein [Function unknown]; Region: COG1432 134676014584 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 134676014585 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 134676014586 YcxB-like protein; Region: YcxB; pfam14317 134676014587 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 134676014588 classical (c) SDRs; Region: SDR_c; cd05233 134676014589 NAD(P) binding site [chemical binding]; other site 134676014590 active site 134676014591 Domain of unknown function (DUF385); Region: DUF385; pfam04075 134676014592 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853 134676014593 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 134676014594 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 134676014595 acyl-CoA synthetase; Validated; Region: PRK07788 134676014596 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 134676014597 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 134676014598 acyl-activating enzyme (AAE) consensus motif; other site 134676014599 AMP binding site [chemical binding]; other site 134676014600 active site 134676014601 CoA binding site [chemical binding]; other site 134676014602 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 134676014603 hydrophobic ligand binding site; other site 134676014604 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 134676014605 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 134676014606 active site 134676014607 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 134676014608 substrate binding site [chemical binding]; other site 134676014609 oxyanion hole (OAH) forming residues; other site 134676014610 trimer interface [polypeptide binding]; other site 134676014611 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 134676014612 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676014613 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 134676014614 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 134676014615 active site 134676014616 YCII-related domain; Region: YCII; cl00999 134676014617 Asp23 family; Region: Asp23; pfam03780 134676014618 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 134676014619 homodimer interface [polypeptide binding]; other site 134676014620 chemical substrate binding site [chemical binding]; other site 134676014621 oligomer interface [polypeptide binding]; other site 134676014622 metal binding site [ion binding]; metal-binding site 134676014623 Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009 134676014624 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 134676014625 G1 box; other site 134676014626 putative GEF interaction site [polypeptide binding]; other site 134676014627 GTP/Mg2+ binding site [chemical binding]; other site 134676014628 Switch I region; other site 134676014629 G2 box; other site 134676014630 G3 box; other site 134676014631 Switch II region; other site 134676014632 G4 box; other site 134676014633 G5 box; other site 134676014634 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 134676014635 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 134676014636 selenocysteine synthase; Provisional; Region: PRK04311 134676014637 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 134676014638 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 134676014639 catalytic motif [active] 134676014640 Catalytic residue [active] 134676014641 Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403 134676014642 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 134676014643 Right handed beta helix region; Region: Beta_helix; pfam13229 134676014644 selenium donor protein; Region: selD; TIGR00476 134676014645 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 134676014646 dimerization interface [polypeptide binding]; other site 134676014647 putative ATP binding site [chemical binding]; other site 134676014648 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 134676014649 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 134676014650 4Fe-4S binding domain; Region: Fer4; pfam00037 134676014651 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 134676014652 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 134676014653 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 134676014654 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 134676014655 molybdopterin cofactor binding site; other site 134676014656 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 134676014657 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 134676014658 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 134676014659 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 134676014660 ATP binding site [chemical binding]; other site 134676014661 Mg++ binding site [ion binding]; other site 134676014662 motif III; other site 134676014663 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 134676014664 nucleotide binding region [chemical binding]; other site 134676014665 ATP-binding site [chemical binding]; other site 134676014666 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 134676014667 RNA binding site [nucleotide binding]; other site 134676014668 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 134676014669 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 134676014670 Walker A motif; other site 134676014671 ATP binding site [chemical binding]; other site 134676014672 Walker B motif; other site 134676014673 Uncharacterized conserved protein [Function unknown]; Region: COG3410 134676014674 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 134676014675 Gametolysin peptidase M11; Region: Peptidase_M11; pfam05548 134676014676 POT family; Region: PTR2; cl17359 134676014677 POT family; Region: PTR2; cl17359 134676014678 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 134676014679 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 134676014680 catalytic residues [active] 134676014681 catalytic nucleophile [active] 134676014682 Recombinase; Region: Recombinase; pfam07508 134676014683 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 134676014684 DDE superfamily endonuclease; Region: DDE_5; cl17874 134676014685 DDE superfamily endonuclease; Region: DDE_5; cl17874 134676014686 HEAT repeats; Region: HEAT_2; pfam13646 134676014687 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 134676014688 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 134676014689 non-specific DNA binding site [nucleotide binding]; other site 134676014690 salt bridge; other site 134676014691 sequence-specific DNA binding site [nucleotide binding]; other site 134676014692 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 134676014693 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 134676014694 sequence-specific DNA binding site [nucleotide binding]; other site 134676014695 salt bridge; other site 134676014696 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 134676014697 GIY-YIG motif/motif A; other site 134676014698 active site 134676014699 catalytic site [active] 134676014700 metal binding site [ion binding]; metal-binding site 134676014701 T5orf172 domain; Region: T5orf172; pfam10544 134676014702 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 134676014703 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 134676014704 cofactor binding site; other site 134676014705 DNA binding site [nucleotide binding] 134676014706 substrate interaction site [chemical binding]; other site 134676014707 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 134676014708 Transcriptional regulator PadR-like family; Region: PadR; cl17335 134676014709 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 134676014710 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 134676014711 dimer interface [polypeptide binding]; other site 134676014712 ssDNA binding site [nucleotide binding]; other site 134676014713 tetramer (dimer of dimers) interface [polypeptide binding]; other site 134676014714 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 134676014715 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 134676014716 DNA binding residues [nucleotide binding] 134676014717 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 134676014718 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 134676014719 non-specific DNA binding site [nucleotide binding]; other site 134676014720 salt bridge; other site 134676014721 sequence-specific DNA binding site [nucleotide binding]; other site 134676014722 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cd00719 134676014723 GIY-YIG motif/motif A; other site 134676014724 active site 134676014725 catalytic site [active] 134676014726 metal binding site [ion binding]; metal-binding site 134676014727 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 134676014728 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 134676014729 Winged helix-turn helix; Region: HTH_29; pfam13551 134676014730 Integrase core domain; Region: rve; pfam00665 134676014731 Integrase core domain; Region: rve_3; pfam13683 134676014732 DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796 134676014733 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 134676014734 Walker A motif; other site 134676014735 ATP binding site [chemical binding]; other site 134676014736 Walker B motif; other site 134676014737 DNA binding loops [nucleotide binding] 134676014738 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 134676014739 dimer interface [polypeptide binding]; other site 134676014740 phosphorylation site [posttranslational modification] 134676014741 GAF domain; Region: GAF; pfam01590 134676014742 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 134676014743 putative CheW interface [polypeptide binding]; other site 134676014744 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 134676014745 anti sigma factor interaction site; other site 134676014746 regulatory phosphorylation site [posttranslational modification]; other site 134676014747 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 134676014748 TPR motif; other site 134676014749 Tetratricopeptide repeat; Region: TPR_12; pfam13424 134676014750 binding surface 134676014751 Tetratricopeptide repeat; Region: TPR_12; pfam13424 134676014752 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 134676014753 binding surface 134676014754 TPR motif; other site 134676014755 Tetratricopeptide repeat; Region: TPR_12; pfam13424 134676014756 Tetratricopeptide repeat; Region: TPR_12; pfam13424 134676014757 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 134676014758 binding surface 134676014759 TPR motif; other site 134676014760 Tetratricopeptide repeat; Region: TPR_12; pfam13424 134676014761 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 134676014762 TPR motif; other site 134676014763 binding surface 134676014764 Tetratricopeptide repeat; Region: TPR_12; pfam13424 134676014765 Tetratricopeptide repeat; Region: TPR_12; pfam13424 134676014766 Tetratricopeptide repeat; Region: TPR_12; pfam13424 134676014767 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 134676014768 binding surface 134676014769 TPR motif; other site 134676014770 Tetratricopeptide repeat; Region: TPR_12; pfam13424 134676014771 IPT/TIG domain; Region: TIG; pfam01833 134676014772 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 134676014773 RHS Repeat; Region: RHS_repeat; pfam05593 134676014774 RHS Repeat; Region: RHS_repeat; pfam05593 134676014775 RHS Repeat; Region: RHS_repeat; pfam05593 134676014776 RHS Repeat; Region: RHS_repeat; pfam05593 134676014777 RHS Repeat; Region: RHS_repeat; cl11982 134676014778 RHS Repeat; Region: RHS_repeat; pfam05593 134676014779 RHS Repeat; Region: RHS_repeat; pfam05593 134676014780 RHS Repeat; Region: RHS_repeat; cl11982 134676014781 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 134676014782 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 134676014783 Domain of unknown function (DUF4259); Region: DUF4259; pfam14078 134676014784 CH-type (Chalaropsis-type) lysozymes represent one of four functionally-defined classes of peptidoglycan hydrolases (also referred to as endo-N-acetylmuramidases) that cleave bacterial cell wall peptidoglycans. CH-type lysozymes exhibit both lysozyme; Region: GH25_CH-type; cd06412 134676014785 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 134676014786 active site 134676014787 Abi-like protein; Region: Abi_2; pfam07751 134676014788 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 134676014789 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 134676014790 DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; cl15861 134676014791 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 134676014792 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 134676014793 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 134676014794 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 134676014795 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 134676014796 DNA binding residues [nucleotide binding] 134676014797 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 134676014798 Protein of unknown function (DUF4240); Region: DUF4240; pfam14024 134676014799 DDE superfamily endonuclease; Region: DDE_5; pfam13546 134676014800 Phosphotransferase enzyme family; Region: APH; pfam01636 134676014801 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 134676014802 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 134676014803 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 134676014804 active site 134676014805 Cation transport protein; Region: TrkH; cl17365 134676014806 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 134676014807 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 134676014808 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 134676014809 Walker A motif; other site 134676014810 ATP binding site [chemical binding]; other site 134676014811 Walker B motif; other site 134676014812 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 134676014813 Winged helix-turn helix; Region: HTH_29; pfam13551 134676014814 Homeodomain-like domain; Region: HTH_32; pfam13565 134676014815 DDE superfamily endonuclease; Region: DDE_3; pfam13358 134676014816 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 134676014817 anti sigma factor interaction site; other site 134676014818 regulatory phosphorylation site [posttranslational modification]; other site 134676014819 GAF domain; Region: GAF; cl17456 134676014820 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 134676014821 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 134676014822 putative CheW interface [polypeptide binding]; other site 134676014823 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 134676014824 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676014825 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 134676014826 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 134676014827 FMN binding site [chemical binding]; other site 134676014828 active site 134676014829 substrate binding site [chemical binding]; other site 134676014830 catalytic residue [active] 134676014831 Helix-turn-helix domain; Region: HTH_28; pfam13518 134676014832 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 134676014833 Coenzyme A binding pocket [chemical binding]; other site 134676014834 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 134676014835 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 134676014836 active site 134676014837 DNA binding site [nucleotide binding] 134676014838 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 134676014839 DNA binding site [nucleotide binding] 134676014840 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 134676014841 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 134676014842 non-specific DNA binding site [nucleotide binding]; other site 134676014843 salt bridge; other site 134676014844 sequence-specific DNA binding site [nucleotide binding]; other site 134676014845 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 134676014846 Coenzyme A binding pocket [chemical binding]; other site 134676014847 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 134676014848 S-adenosylmethionine binding site [chemical binding]; other site 134676014849 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 134676014850 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 134676014851 helicase superfamily c-terminal domain; Region: HELICc; smart00490 134676014852 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 134676014853 Family description; Region: UvrD_C_2; pfam13538 134676014854 AAA-like domain; Region: AAA_10; pfam12846 134676014855 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 134676014856 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 134676014857 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 134676014858 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 134676014859 active site 134676014860 metal binding site [ion binding]; metal-binding site 134676014861 interdomain interaction site; other site 134676014862 MafB19-like deaminase; Region: MafB19-deam; pfam14437 134676014863 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 134676014864 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 134676014865 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 134676014866 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 134676014867 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 134676014868 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 134676014869 Transposase, Mutator family; Region: Transposase_mut; pfam00872 134676014870 MULE transposase domain; Region: MULE; pfam10551 134676014871 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 134676014872 RIP homotypic interaction motif; Region: RHIM; pfam12721 134676014873 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 134676014874 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 134676014875 catalytic site [active] 134676014876 DDE superfamily endonuclease; Region: DDE_5; pfam13546 134676014877 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 134676014878 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 134676014879 Replication protein A C terminal; Region: RPA_C; pfam08784 134676014880 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 134676014881 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 134676014882 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 134676014883 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 134676014884 peptidase domain interface [polypeptide binding]; other site 134676014885 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 134676014886 active site 134676014887 catalytic triad [active] 134676014888 calcium binding site [ion binding]; other site 134676014889 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 134676014890 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 134676014891 Peptidase family M23; Region: Peptidase_M23; pfam01551 134676014892 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 134676014893 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 134676014894 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 134676014895 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 134676014896 HAMP domain; Region: HAMP; pfam00672 134676014897 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 134676014898 dimer interface [polypeptide binding]; other site 134676014899 phosphorylation site [posttranslational modification] 134676014900 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676014901 ATP binding site [chemical binding]; other site 134676014902 Mg2+ binding site [ion binding]; other site 134676014903 G-X-G motif; other site 134676014904 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 134676014905 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676014906 active site 134676014907 phosphorylation site [posttranslational modification] 134676014908 intermolecular recognition site; other site 134676014909 dimerization interface [polypeptide binding]; other site 134676014910 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 134676014911 DNA binding site [nucleotide binding] 134676014912 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 134676014913 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 134676014914 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 134676014915 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 134676014916 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 134676014917 Transposase; Region: DEDD_Tnp_IS110; pfam01548 134676014918 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 134676014919 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 134676014920 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 134676014921 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 134676014922 DNA binding residues [nucleotide binding] 134676014923 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 134676014924 POT family; Region: PTR2; cl17359 134676014925 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 134676014926 EamA-like transporter family; Region: EamA; pfam00892 134676014927 EamA-like transporter family; Region: EamA; pfam00892 134676014928 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 134676014929 Coenzyme A binding pocket [chemical binding]; other site 134676014930 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 134676014931 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 134676014932 active site 134676014933 Zn binding site [ion binding]; other site 134676014934 alpha-galactosidase; Region: PLN02808; cl17638 134676014935 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 134676014936 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 134676014937 putative sugar binding sites [chemical binding]; other site 134676014938 Q-X-W motif; other site 134676014939 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 134676014940 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 134676014941 putative sugar binding sites [chemical binding]; other site 134676014942 Q-X-W motif; other site 134676014943 Transcriptional regulators [Transcription]; Region: PurR; COG1609 134676014944 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 134676014945 DNA binding site [nucleotide binding] 134676014946 domain linker motif; other site 134676014947 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 134676014948 ligand binding site [chemical binding]; other site 134676014949 dimerization interface [polypeptide binding]; other site 134676014950 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 134676014951 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 134676014952 active site 134676014953 metal binding site [ion binding]; metal-binding site 134676014954 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 134676014955 mycofactocin system glycosyltransferase; Region: mycofact_glyco; TIGR03965 134676014956 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 134676014957 active site 134676014958 Creatinine amidohydrolase; Region: Creatininase; cl00618 134676014959 mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962 134676014960 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 134676014961 FeS/SAM binding site; other site 134676014962 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 134676014963 putative mycofactocin binding protein MftB; Region: mycofact_MftB; TIGR03967 134676014964 AAA ATPase domain; Region: AAA_16; pfam13191 134676014965 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 134676014966 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 134676014967 DNA binding residues [nucleotide binding] 134676014968 dimerization interface [polypeptide binding]; other site 134676014969 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 134676014970 classical (c) SDRs; Region: SDR_c; cd05233 134676014971 NAD(P) binding site [chemical binding]; other site 134676014972 active site 134676014973 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 134676014974 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 134676014975 polyketide synthase gene cluster (cACPL_2) 134676014976 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 134676014977 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 134676014978 active site 134676014979 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 134676014980 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 134676014981 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 134676014982 putative NADP binding site [chemical binding]; other site 134676014983 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 134676014984 active site 134676014985 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 134676014986 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 134676014987 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 134676014988 active site 134676014989 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 134676014990 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 134676014991 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 134676014992 putative NADP binding site [chemical binding]; other site 134676014993 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 134676014994 active site 134676014995 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 134676014996 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 134676014997 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 134676014998 active site 134676014999 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 134676015000 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 134676015001 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 134676015002 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 134676015003 putative NADP binding site [chemical binding]; other site 134676015004 active site 134676015005 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 134676015006 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 134676015007 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 134676015008 active site 134676015009 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 134676015010 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 134676015011 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 134676015012 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 134676015013 putative NADP binding site [chemical binding]; other site 134676015014 active site 134676015015 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 134676015016 Thioesterase; Region: PKS_TE; smart00824 134676015017 Erythronolide synthase docking; Region: Docking; pfam08990 134676015018 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 134676015019 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 134676015020 active site 134676015021 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 134676015022 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 134676015023 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 134676015024 putative NADP binding site [chemical binding]; other site 134676015025 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 134676015026 active site 134676015027 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 134676015028 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 134676015029 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 134676015030 active site 134676015031 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 134676015032 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 134676015033 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 134676015034 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 134676015035 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 134676015036 putative NADP binding site [chemical binding]; other site 134676015037 active site 134676015038 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 134676015039 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 134676015040 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 134676015041 active site 134676015042 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 134676015043 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 134676015044 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 134676015045 putative NADP binding site [chemical binding]; other site 134676015046 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 134676015047 active site 134676015048 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 134676015049 Erythronolide synthase docking; Region: Docking; pfam08990 134676015050 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 134676015051 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 134676015052 active site 134676015053 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 134676015054 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 134676015055 NADP binding site [chemical binding]; other site 134676015056 KR domain; Region: KR; pfam08659 134676015057 active site 134676015058 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 134676015059 Erythronolide synthase docking; Region: Docking; pfam08990 134676015060 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 134676015061 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 134676015062 active site 134676015063 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 134676015064 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 134676015065 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 134676015066 putative NADP binding site [chemical binding]; other site 134676015067 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 134676015068 active site 134676015069 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 134676015070 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 134676015071 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 134676015072 active site 134676015073 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 134676015074 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 134676015075 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 134676015076 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 134676015077 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 134676015078 hydrophobic ligand binding site; other site 134676015079 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 134676015080 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 134676015081 DNA binding residues [nucleotide binding] 134676015082 dimerization interface [polypeptide binding]; other site 134676015083 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 134676015084 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 134676015085 putative substrate translocation pore; other site 134676015086 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 134676015087 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 134676015088 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676015089 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 134676015090 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 134676015091 Transposase, Mutator family; Region: Transposase_mut; pfam00872 134676015092 MULE transposase domain; Region: MULE; pfam10551 134676015093 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 134676015094 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 134676015095 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 134676015096 Transposase; Region: DEDD_Tnp_IS110; pfam01548 134676015097 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 134676015098 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 134676015099 DNA binding site [nucleotide binding] 134676015100 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 134676015101 polyketide synthase gene cluster (cACPL_3) 134676015102 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 134676015103 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676015104 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 134676015105 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 134676015106 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 134676015107 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 134676015108 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 134676015109 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 134676015110 active site 134676015111 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 134676015112 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 134676015113 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 134676015114 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 134676015115 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 134676015116 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 134676015117 putative NADP binding site [chemical binding]; other site 134676015118 active site 134676015119 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 134676015120 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 134676015121 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 134676015122 active site 134676015123 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 134676015124 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 134676015125 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 134676015126 putative NADP binding site [chemical binding]; other site 134676015127 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 134676015128 active site 134676015129 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 134676015130 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 134676015131 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 134676015132 active site 134676015133 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 134676015134 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 134676015135 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 134676015136 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 134676015137 putative NADP binding site [chemical binding]; other site 134676015138 active site 134676015139 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 134676015140 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 134676015141 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 134676015142 acyl-activating enzyme (AAE) consensus motif; other site 134676015143 AMP binding site [chemical binding]; other site 134676015144 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 134676015145 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 134676015146 acyl-activating enzyme (AAE) consensus motif; other site 134676015147 AMP binding site [chemical binding]; other site 134676015148 acyl carrier protein; Provisional; Region: PRK07081 134676015149 Acyl transferase domain; Region: Acyl_transf_1; cl08282 134676015150 Acyl transferase domain; Region: Acyl_transf_1; cl08282 134676015151 aspartate aminotransferase; Provisional; Region: PRK05764 134676015152 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 134676015153 pyridoxal 5'-phosphate binding site [chemical binding]; other site 134676015154 homodimer interface [polypeptide binding]; other site 134676015155 catalytic residue [active] 134676015156 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 134676015157 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 134676015158 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 134676015159 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 134676015160 heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966 134676015161 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 134676015162 phosphate binding site [ion binding]; other site 134676015163 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 134676015164 classical (c) SDRs; Region: SDR_c; cd05233 134676015165 active site 134676015166 PAS fold; Region: PAS_4; pfam08448 134676015167 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 134676015168 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676015169 metal binding site [ion binding]; metal-binding site 134676015170 active site 134676015171 I-site; other site 134676015172 Protein of unknown function (DUF1565); Region: DUF1565; pfam07602 134676015173 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 134676015174 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 134676015175 dimer interface [polypeptide binding]; other site 134676015176 conserved gate region; other site 134676015177 putative PBP binding loops; other site 134676015178 ABC-ATPase subunit interface; other site 134676015179 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 134676015180 dimer interface [polypeptide binding]; other site 134676015181 conserved gate region; other site 134676015182 putative PBP binding loops; other site 134676015183 ABC-ATPase subunit interface; other site 134676015184 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 134676015185 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 134676015186 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 134676015187 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 134676015188 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 134676015189 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 134676015190 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 134676015191 MarR family; Region: MarR; pfam01047 134676015192 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 134676015193 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 134676015194 allophanate hydrolase; Provisional; Region: PRK08186 134676015195 Amidase; Region: Amidase; cl11426 134676015196 urea carboxylase; Region: urea_carbox; TIGR02712 134676015197 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 134676015198 ATP-grasp domain; Region: ATP-grasp_4; cl17255 134676015199 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 134676015200 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 134676015201 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 134676015202 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 134676015203 carboxyltransferase (CT) interaction site; other site 134676015204 biotinylation site [posttranslational modification]; other site 134676015205 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 134676015206 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 134676015207 urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425 134676015208 permease, urea carboxylase system; Region: ureacarb_perm; TIGR03428 134676015209 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 134676015210 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676015211 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 134676015212 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 134676015213 active site 134676015214 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 134676015215 Ligand binding site; other site 134676015216 Putative Catalytic site; other site 134676015217 DXD motif; other site 134676015218 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 134676015219 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 134676015220 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 134676015221 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 134676015222 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 134676015223 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 134676015224 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 134676015225 structural tetrad; other site 134676015226 FOG: WD40 repeat [General function prediction only]; Region: COG2319 134676015227 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 134676015228 structural tetrad; other site 134676015229 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 134676015230 ATP binding site [chemical binding]; other site 134676015231 Tetratricopeptide repeat; Region: TPR_16; pfam13432 134676015232 FOG: WD40 repeat [General function prediction only]; Region: COG2319 134676015233 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 134676015234 structural tetrad; other site 134676015235 FOG: WD40 repeat [General function prediction only]; Region: COG2319 134676015236 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 134676015237 structural tetrad; other site 134676015238 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 134676015239 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 134676015240 CBD_II domain; Region: CBD_II; smart00637 134676015241 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 134676015242 PS-10 peptidase S37; Region: Peptidase_S37; pfam05576 134676015243 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 134676015244 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676015245 metal binding site [ion binding]; metal-binding site 134676015246 active site 134676015247 I-site; other site 134676015248 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 134676015249 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 134676015250 active site 134676015251 Zn binding site [ion binding]; other site 134676015252 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 134676015253 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676015254 active site 134676015255 phosphorylation site [posttranslational modification] 134676015256 intermolecular recognition site; other site 134676015257 dimerization interface [polypeptide binding]; other site 134676015258 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 134676015259 DNA binding site [nucleotide binding] 134676015260 non-ribosomal/polyketide synthase gene cluster (cACPL_4) 134676015261 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 134676015262 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 134676015263 dimerization interface [polypeptide binding]; other site 134676015264 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676015265 ATP binding site [chemical binding]; other site 134676015266 Mg2+ binding site [ion binding]; other site 134676015267 G-X-G motif; other site 134676015268 Condensation domain; Region: Condensation; pfam00668 134676015269 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 134676015270 Nonribosomal peptide synthase; Region: NRPS; pfam08415 134676015271 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 134676015272 acyl-activating enzyme (AAE) consensus motif; other site 134676015273 AMP binding site [chemical binding]; other site 134676015274 Methyltransferase domain; Region: Methyltransf_23; pfam13489 134676015275 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 134676015276 S-adenosylmethionine binding site [chemical binding]; other site 134676015277 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 134676015278 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 134676015279 Thioesterase domain; Region: Thioesterase; pfam00975 134676015280 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 134676015281 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676015282 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 134676015283 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 134676015284 Cytochrome P450; Region: p450; cl12078 134676015285 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 134676015286 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 134676015287 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 134676015288 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 134676015289 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 134676015290 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 134676015291 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 134676015292 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 134676015293 active site 134676015294 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 134676015295 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 134676015296 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 134676015297 active site 134676015298 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 134676015299 KR domain; Region: KR; pfam08659 134676015300 NAD(P) binding site [chemical binding]; other site 134676015301 active site 134676015302 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 134676015303 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 134676015304 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 134676015305 active site 134676015306 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 134676015307 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 134676015308 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 134676015309 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 134676015310 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 134676015311 NAD(P) binding site [chemical binding]; other site 134676015312 active site 134676015313 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 134676015314 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 134676015315 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 134676015316 active site 134676015317 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 134676015318 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 134676015319 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 134676015320 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 134676015321 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 134676015322 NAD(P) binding site [chemical binding]; other site 134676015323 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 134676015324 NAD(P) binding site [chemical binding]; other site 134676015325 KR domain; Region: KR; pfam08659 134676015326 active site 134676015327 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 134676015328 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 134676015329 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 134676015330 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 134676015331 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 134676015332 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 134676015333 B12 binding site [chemical binding]; other site 134676015334 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 134676015335 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 134676015336 DNA binding site [nucleotide binding] 134676015337 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 134676015338 NB-ARC domain; Region: NB-ARC; pfam00931 134676015339 salicylate synthase; Region: salicyl_syn; TIGR03494 134676015340 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 134676015341 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 134676015342 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 134676015343 acyl-activating enzyme (AAE) consensus motif; other site 134676015344 active site 134676015345 AMP binding site [chemical binding]; other site 134676015346 substrate binding site [chemical binding]; other site 134676015347 Thioesterase domain; Region: Thioesterase; pfam00975 134676015348 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 134676015349 Condensation domain; Region: Condensation; pfam00668 134676015350 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 134676015351 Nonribosomal peptide synthase; Region: NRPS; pfam08415 134676015352 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 134676015353 acyl-activating enzyme (AAE) consensus motif; other site 134676015354 AMP binding site [chemical binding]; other site 134676015355 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 134676015356 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 134676015357 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 134676015358 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 134676015359 Walker A/P-loop; other site 134676015360 ATP binding site [chemical binding]; other site 134676015361 Q-loop/lid; other site 134676015362 ABC transporter signature motif; other site 134676015363 Walker B; other site 134676015364 D-loop; other site 134676015365 H-loop/switch region; other site 134676015366 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 134676015367 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 134676015368 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 134676015369 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 134676015370 Walker A/P-loop; other site 134676015371 ATP binding site [chemical binding]; other site 134676015372 Q-loop/lid; other site 134676015373 ABC transporter signature motif; other site 134676015374 Walker B; other site 134676015375 D-loop; other site 134676015376 H-loop/switch region; other site 134676015377 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 134676015378 putative substrate translocation pore; other site 134676015379 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 134676015380 LabA_like proteins; Region: LabA_like; cd06167 134676015381 putative metal binding site [ion binding]; other site 134676015382 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 134676015383 AAA ATPase domain; Region: AAA_16; pfam13191 134676015384 AAA ATPase domain; Region: AAA_16; pfam13191 134676015385 oxidoreductase; Provisional; Region: PRK06128 134676015386 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 134676015387 NAD binding site [chemical binding]; other site 134676015388 metal binding site [ion binding]; metal-binding site 134676015389 active site 134676015390 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 134676015391 anti sigma factor interaction site; other site 134676015392 regulatory phosphorylation site [posttranslational modification]; other site 134676015393 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 134676015394 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 134676015395 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 134676015396 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 134676015397 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 134676015398 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 134676015399 DNA binding residues [nucleotide binding] 134676015400 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 134676015401 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 134676015402 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 134676015403 putative sugar binding sites [chemical binding]; other site 134676015404 Q-X-W motif; other site 134676015405 Glycosyl hydrolase family 59; Region: Glyco_hydro_59; pfam02057 134676015406 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 134676015407 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 134676015408 putative sugar binding sites [chemical binding]; other site 134676015409 Q-X-W motif; other site 134676015410 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 134676015411 MepB protein; Region: MepB; cl01985 134676015412 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 134676015413 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 134676015414 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676015415 metal binding site [ion binding]; metal-binding site 134676015416 active site 134676015417 I-site; other site 134676015418 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 134676015419 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676015420 metal binding site [ion binding]; metal-binding site 134676015421 active site 134676015422 I-site; other site 134676015423 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 134676015424 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 134676015425 DNA binding residues [nucleotide binding] 134676015426 dimerization interface [polypeptide binding]; other site 134676015427 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 134676015428 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 134676015429 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 134676015430 Coenzyme A binding pocket [chemical binding]; other site 134676015431 NRPS/PKS 134676015432 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 134676015433 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 134676015434 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 134676015435 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 134676015436 acyl-activating enzyme (AAE) consensus motif; other site 134676015437 AMP binding site [chemical binding]; other site 134676015438 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 134676015439 Condensation domain; Region: Condensation; pfam00668 134676015440 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 134676015441 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 134676015442 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 134676015443 acyl-activating enzyme (AAE) consensus motif; other site 134676015444 AMP binding site [chemical binding]; other site 134676015445 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 134676015446 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 134676015447 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 134676015448 active site 134676015449 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 134676015450 Cupin domain; Region: Cupin_2; cl17218 134676015451 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 134676015452 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 134676015453 pyridoxal 5'-phosphate binding site [chemical binding]; other site 134676015454 homodimer interface [polypeptide binding]; other site 134676015455 catalytic residue [active] 134676015456 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 134676015457 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 134676015458 GTPase RsgA; Reviewed; Region: PRK01889 134676015459 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 134676015460 GTPase/Zn-binding domain interface [polypeptide binding]; other site 134676015461 GTP/Mg2+ binding site [chemical binding]; other site 134676015462 G4 box; other site 134676015463 G5 box; other site 134676015464 G1 box; other site 134676015465 Switch I region; other site 134676015466 G2 box; other site 134676015467 G3 box; other site 134676015468 Switch II region; other site 134676015469 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 134676015470 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 134676015471 DNA binding site [nucleotide binding] 134676015472 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 134676015473 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676015474 metal binding site [ion binding]; metal-binding site 134676015475 active site 134676015476 I-site; other site 134676015477 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 134676015478 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 134676015479 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676015480 metal binding site [ion binding]; metal-binding site 134676015481 active site 134676015482 I-site; other site 134676015483 Histidine kinase; Region: HisKA_3; pfam07730 134676015484 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 134676015485 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 134676015486 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676015487 active site 134676015488 phosphorylation site [posttranslational modification] 134676015489 intermolecular recognition site; other site 134676015490 dimerization interface [polypeptide binding]; other site 134676015491 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 134676015492 DNA binding residues [nucleotide binding] 134676015493 dimerization interface [polypeptide binding]; other site 134676015494 Beta-lactamase; Region: Beta-lactamase; pfam00144 134676015495 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 134676015496 CAAX protease self-immunity; Region: Abi; pfam02517 134676015497 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 134676015498 hydrophobic ligand binding site; other site 134676015499 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 134676015500 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 134676015501 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 134676015502 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 134676015503 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 134676015504 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 134676015505 Right handed beta helix region; Region: Beta_helix; pfam13229 134676015506 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 134676015507 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 134676015508 Protein of unknown function (DUF1565); Region: DUF1565; pfam07602 134676015509 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 134676015510 H+ Antiporter protein; Region: 2A0121; TIGR00900 134676015511 putative substrate translocation pore; other site 134676015512 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 134676015513 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 134676015514 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 134676015515 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 134676015516 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 134676015517 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 134676015518 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 134676015519 catalytic residue [active] 134676015520 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 134676015521 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 134676015522 active site 134676015523 substrate binding site [chemical binding]; other site 134676015524 cosubstrate binding site; other site 134676015525 catalytic site [active] 134676015526 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 134676015527 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 134676015528 active site 134676015529 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 134676015530 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 134676015531 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 134676015532 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 134676015533 dimer interface [polypeptide binding]; other site 134676015534 active site 134676015535 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 134676015536 Ligand Binding Site [chemical binding]; other site 134676015537 Molecular Tunnel; other site 134676015538 H+ Antiporter protein; Region: 2A0121; TIGR00900 134676015539 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 134676015540 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 134676015541 Condensation domain; Region: Condensation; pfam00668 134676015542 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 134676015543 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 134676015544 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 134676015545 active site 134676015546 acyl carrier protein; Provisional; Region: PRK07081 134676015547 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 134676015548 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Btrk Decarboxylase; Region: PLPDE_III_Btrk_like; cd06839 134676015549 dimer interface [polypeptide binding]; other site 134676015550 active site 134676015551 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 134676015552 catalytic residues [active] 134676015553 substrate binding site [chemical binding]; other site 134676015554 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 134676015555 AMP-binding enzyme; Region: AMP-binding; pfam00501 134676015556 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 134676015557 acyl-activating enzyme (AAE) consensus motif; other site 134676015558 acyl-activating enzyme (AAE) consensus motif; other site 134676015559 AMP binding site [chemical binding]; other site 134676015560 active site 134676015561 CoA binding site [chemical binding]; other site 134676015562 Flavin Reductases; Region: FlaRed; cl00801 134676015563 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 134676015564 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 134676015565 inhibitor-cofactor binding pocket; inhibition site 134676015566 pyridoxal 5'-phosphate binding site [chemical binding]; other site 134676015567 catalytic residue [active] 134676015568 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 134676015569 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 134676015570 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 134676015571 active site 134676015572 NAD binding site [chemical binding]; other site 134676015573 metal binding site [ion binding]; metal-binding site 134676015574 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 134676015575 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 134676015576 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 134676015577 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 134676015578 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 134676015579 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 134676015580 NlpC/P60 family; Region: NLPC_P60; pfam00877 134676015581 Protein of unknown function (DUF1348); Region: DUF1348; pfam07080 134676015582 SnoaL-like domain; Region: SnoaL_2; pfam12680 134676015583 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 134676015584 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 134676015585 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 134676015586 CGNR zinc finger; Region: zf-CGNR; pfam11706 134676015587 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 134676015588 Transposase; Region: DDE_Tnp_ISL3; pfam01610 134676015589 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 134676015590 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 134676015591 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 134676015592 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 134676015593 Protein of unknown function (DUF4240); Region: DUF4240; pfam14024 134676015594 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 134676015595 Helix-turn-helix domain; Region: HTH_38; pfam13936 134676015596 Integrase core domain; Region: rve; pfam00665 134676015597 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 134676015598 Transposase; Region: HTH_Tnp_1; cl17663 134676015599 Domain of unknown function (DUF397); Region: DUF397; pfam04149 134676015600 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 134676015601 Int/Topo IB signature motif; other site 134676015602 identity site (attB) (original part of tRNA gene) 134676015603 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 134676015604 nudix motif; other site 134676015605 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 134676015606 cluster similar to that of Micromonospora aurantiaca ATCC 27029 134676015607 DNA polymerase II large subunit; Validated; Region: PRK04023 134676015608 Helix-turn-helix domain; Region: HTH_17; pfam12728 134676015609 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 134676015610 Phage integrase family; Region: Phage_integrase; pfam00589 134676015611 active site 134676015612 DNA binding site [nucleotide binding] 134676015613 Int/Topo IB signature motif; other site 134676015614 identity site (attP) (inserted part of tRNA gene) 134676015615 ribosome-associated GTPase EngA; Region: GTPase_EngA; TIGR03594 134676015616 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 134676015617 GTP/Mg2+ binding site [chemical binding]; other site 134676015618 G2 box; other site 134676015619 Switch I region; other site 134676015620 G3 box; other site 134676015621 Switch II region; other site 134676015622 G4 box; other site 134676015623 G5 box; other site 134676015624 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 134676015625 G1 box; other site 134676015626 GTP/Mg2+ binding site [chemical binding]; other site 134676015627 Switch I region; other site 134676015628 G2 box; other site 134676015629 G3 box; other site 134676015630 Switch II region; other site 134676015631 G4 box; other site 134676015632 G5 box; other site 134676015633 cytidylate kinase; Provisional; Region: cmk; PRK00023 134676015634 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 134676015635 CMP-binding site; other site 134676015636 The sites determining sugar specificity; other site 134676015637 HD domain; Region: HD_4; pfam13328 134676015638 RF-1 domain; Region: RF-1; cl17422 134676015639 hypothetical protein; Reviewed; Region: PRK09588 134676015640 Uncharacterized protein family UPF0027; Region: UPF0027; cl17455 134676015641 acyl-CoA synthetase; Validated; Region: PRK07787 134676015642 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 134676015643 acyl-activating enzyme (AAE) consensus motif; other site 134676015644 AMP binding site [chemical binding]; other site 134676015645 active site 134676015646 CoA binding site [chemical binding]; other site 134676015647 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 134676015648 active site 134676015649 metal binding site [ion binding]; metal-binding site 134676015650 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 134676015651 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 134676015652 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 134676015653 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 134676015654 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 134676015655 RNA binding surface [nucleotide binding]; other site 134676015656 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 134676015657 active site 134676015658 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 134676015659 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 134676015660 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 134676015661 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 134676015662 conserved cys residue [active] 134676015663 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 134676015664 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 134676015665 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 134676015666 conserved cys residue [active] 134676015667 Transcriptional regulators [Transcription]; Region: MarR; COG1846 134676015668 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 134676015669 Domain of unknown function (DUF385); Region: DUF385; cl04387 134676015670 short chain dehydrogenase; Provisional; Region: PRK07454 134676015671 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 134676015672 NAD(P) binding site [chemical binding]; other site 134676015673 active site 134676015674 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 134676015675 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 134676015676 P-loop; other site 134676015677 Magnesium ion binding site [ion binding]; other site 134676015678 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 134676015679 Magnesium ion binding site [ion binding]; other site 134676015680 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 134676015681 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 134676015682 active site 134676015683 DNA binding site [nucleotide binding] 134676015684 Int/Topo IB signature motif; other site 134676015685 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 134676015686 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 134676015687 hexamer interface [polypeptide binding]; other site 134676015688 ligand binding site [chemical binding]; other site 134676015689 putative active site [active] 134676015690 NAD(P) binding site [chemical binding]; other site 134676015691 Barstar_SaI14_like contains sequences that are similar to SaI14, an RNAase inhibitor, which are members of the Barstar family. Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds...; Region: Barstar_SaI14_like; cd05143 134676015692 putative RNAase interaction site [polypeptide binding]; other site 134676015693 Cellulose binding domain; Region: CBM_2; pfam00553 134676015694 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 134676015695 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 134676015696 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 134676015697 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 134676015698 NmrA-like family; Region: NmrA; pfam05368 134676015699 NAD(P) binding site [chemical binding]; other site 134676015700 active site 134676015701 Predicted transcriptional regulators [Transcription]; Region: COG1733 134676015702 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 134676015703 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 134676015704 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 134676015705 active site 134676015706 metal binding site [ion binding]; metal-binding site 134676015707 TAP-like protein; Region: Abhydrolase_4; pfam08386 134676015708 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 134676015709 dimer interface [polypeptide binding]; other site 134676015710 active site 134676015711 ADP-ribose binding site [chemical binding]; other site 134676015712 nudix motif; other site 134676015713 metal binding site [ion binding]; metal-binding site 134676015714 CTP synthetase; Validated; Region: pyrG; PRK05380 134676015715 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 134676015716 Catalytic site [active] 134676015717 active site 134676015718 UTP binding site [chemical binding]; other site 134676015719 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 134676015720 active site 134676015721 putative oxyanion hole; other site 134676015722 catalytic triad [active] 134676015723 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 134676015724 glycosyltransferase, MSMEG_0565 family; Region: MSMEG_0565_glyc; TIGR04047 134676015725 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 134676015726 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 134676015727 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 134676015728 Thiamine pyrophosphokinase; Region: TPK; cl08415 134676015729 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 134676015730 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 134676015731 Walker A/P-loop; other site 134676015732 ATP binding site [chemical binding]; other site 134676015733 Q-loop/lid; other site 134676015734 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 134676015735 ABC transporter signature motif; other site 134676015736 Walker B; other site 134676015737 D-loop; other site 134676015738 H-loop/switch region; other site 134676015739 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 134676015740 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708 134676015741 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 134676015742 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 134676015743 RNA binding surface [nucleotide binding]; other site 134676015744 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 134676015745 Uncharacterized conserved protein [Function unknown]; Region: COG3937 134676015746 SCP-2 sterol transfer family; Region: SCP2; pfam02036 134676015747 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 134676015748 dimer interface [polypeptide binding]; other site 134676015749 putative CheW interface [polypeptide binding]; other site 134676015750 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 134676015751 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 134676015752 active site 134676015753 motif I; other site 134676015754 motif II; other site 134676015755 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 134676015756 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 134676015757 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 134676015758 active site 134676015759 HIGH motif; other site 134676015760 dimer interface [polypeptide binding]; other site 134676015761 KMSKS motif; other site 134676015762 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 134676015763 RNA binding surface [nucleotide binding]; other site 134676015764 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 134676015765 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 134676015766 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 134676015767 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 134676015768 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 134676015769 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 134676015770 dimerization domain swap beta strand [polypeptide binding]; other site 134676015771 regulatory protein interface [polypeptide binding]; other site 134676015772 active site 134676015773 regulatory phosphorylation site [posttranslational modification]; other site 134676015774 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 134676015775 L-iditol 2-dehydrogenase; Region: iditol_2_DH_like; cd08235 134676015776 putative NAD(P) binding site [chemical binding]; other site 134676015777 catalytic Zn binding site [ion binding]; other site 134676015778 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 134676015779 active site 134676015780 phosphorylation site [posttranslational modification] 134676015781 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 134676015782 active site 134676015783 P-loop; other site 134676015784 phosphorylation site [posttranslational modification] 134676015785 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 134676015786 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 134676015787 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 134676015788 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 134676015789 putative substrate binding site [chemical binding]; other site 134676015790 putative ATP binding site [chemical binding]; other site 134676015791 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 134676015792 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 134676015793 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 134676015794 Transcriptional regulator [Transcription]; Region: LysR; COG0583 134676015795 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 134676015796 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 134676015797 putative substrate binding pocket [chemical binding]; other site 134676015798 putative dimerization interface [polypeptide binding]; other site 134676015799 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 134676015800 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 134676015801 putative substrate translocation pore; other site 134676015802 adenylate kinase; Reviewed; Region: adk; PRK00279 134676015803 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 134676015804 AMP-binding site [chemical binding]; other site 134676015805 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 134676015806 PemK-like protein; Region: PemK; pfam02452 134676015807 agmatinase; Region: agmatinase; TIGR01230 134676015808 Agmatinase-like family; Region: Agmatinase-like; cd09990 134676015809 active site 134676015810 oligomer interface [polypeptide binding]; other site 134676015811 Mn binding site [ion binding]; other site 134676015812 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 134676015813 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 134676015814 Domain of unknown function (DUF397); Region: DUF397; pfam04149 134676015815 Helix-turn-helix domain; Region: HTH_31; pfam13560 134676015816 Methylpurine-DNA glycosylase (MPG); Region: Pur_DNA_glyco; pfam02245 134676015817 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 134676015818 Part of AAA domain; Region: AAA_19; pfam13245 134676015819 Family description; Region: UvrD_C_2; pfam13538 134676015820 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 134676015821 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 134676015822 PhoD-like phosphatase; Region: PhoD; pfam09423 134676015823 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 134676015824 putative active site [active] 134676015825 putative metal binding site [ion binding]; other site 134676015826 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 134676015827 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 134676015828 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 134676015829 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 134676015830 maltose cluster 134676015831 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 134676015832 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 134676015833 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 134676015834 active site 134676015835 catalytic site [active] 134676015836 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 134676015837 carbohydrate binding site [chemical binding]; other site 134676015838 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 134676015839 carbohydrate binding site [chemical binding]; other site 134676015840 alpha-1,6-glucosidases, pullulanase-type; Region: pullul_strch; TIGR02103 134676015841 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 134676015842 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 134676015843 Ca binding site [ion binding]; other site 134676015844 active site 134676015845 catalytic site [active] 134676015846 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 134676015847 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 134676015848 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 134676015849 dimer interface [polypeptide binding]; other site 134676015850 conserved gate region; other site 134676015851 putative PBP binding loops; other site 134676015852 ABC-ATPase subunit interface; other site 134676015853 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 134676015854 dimer interface [polypeptide binding]; other site 134676015855 conserved gate region; other site 134676015856 ABC-ATPase subunit interface; other site 134676015857 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 134676015858 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 134676015859 Transcriptional regulators [Transcription]; Region: PurR; COG1609 134676015860 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 134676015861 DNA binding site [nucleotide binding] 134676015862 domain linker motif; other site 134676015863 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_10; cd06292 134676015864 putative dimerization interface [polypeptide binding]; other site 134676015865 putative ligand binding site [chemical binding]; other site 134676015866 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 134676015867 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 134676015868 metal binding site [ion binding]; metal-binding site 134676015869 putative dimer interface [polypeptide binding]; other site 134676015870 argininosuccinate lyase; Provisional; Region: PRK00855 134676015871 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 134676015872 active sites [active] 134676015873 tetramer interface [polypeptide binding]; other site 134676015874 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 134676015875 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 134676015876 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676015877 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 134676015878 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 134676015879 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 134676015880 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 134676015881 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 134676015882 heterotetramer interface [polypeptide binding]; other site 134676015883 active site pocket [active] 134676015884 cleavage site 134676015885 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 134676015886 feedback inhibition sensing region; other site 134676015887 homohexameric interface [polypeptide binding]; other site 134676015888 nucleotide binding site [chemical binding]; other site 134676015889 N-acetyl-L-glutamate binding site [chemical binding]; other site 134676015890 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 134676015891 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 134676015892 inhibitor-cofactor binding pocket; inhibition site 134676015893 pyridoxal 5'-phosphate binding site [chemical binding]; other site 134676015894 catalytic residue [active] 134676015895 ornithine carbamoyltransferase; Provisional; Region: PRK00779 134676015896 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 134676015897 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 134676015898 arginine repressor; Provisional; Region: PRK03341 134676015899 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 134676015900 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 134676015901 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 134676015902 Ligand Binding Site [chemical binding]; other site 134676015903 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 134676015904 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 134676015905 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 134676015906 DNA binding residues [nucleotide binding] 134676015907 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 134676015908 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 134676015909 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 134676015910 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 134676015911 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 134676015912 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 134676015913 putative active site [active] 134676015914 putative dimer interface [polypeptide binding]; other site 134676015915 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 134676015916 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 134676015917 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 134676015918 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 134676015919 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 134676015920 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 134676015921 Short repeats of unknown function; Region: ALF; pfam03752 134676015922 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 134676015923 protein-splicing catalytic site; other site 134676015924 thioester formation/cholesterol transfer; other site 134676015925 Pretoxin HINT domain; Region: PT-HINT; pfam07591 134676015926 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 134676015927 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 134676015928 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 134676015929 putative active site [active] 134676015930 hypothetical protein; Provisional; Region: PRK08244 134676015931 hypothetical protein; Provisional; Region: PRK07236 134676015932 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 134676015933 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 134676015934 M28 Zn-Peptidase Aeromonas (Vibrio) proteolytica aminopeptidase (AAP)-like; Region: M28_AAP_like; cd05642 134676015935 putative metal binding site [ion binding]; other site 134676015936 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 134676015937 Domain of unknown function (DUF4419); Region: DUF4419; pfam14388 134676015938 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 134676015939 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 134676015940 putative tRNA-binding site [nucleotide binding]; other site 134676015941 B3/4 domain; Region: B3_4; pfam03483 134676015942 tRNA synthetase B5 domain; Region: B5; smart00874 134676015943 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 134676015944 dimer interface [polypeptide binding]; other site 134676015945 motif 1; other site 134676015946 motif 3; other site 134676015947 motif 2; other site 134676015948 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 134676015949 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 134676015950 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 134676015951 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 134676015952 dimer interface [polypeptide binding]; other site 134676015953 motif 1; other site 134676015954 active site 134676015955 motif 2; other site 134676015956 motif 3; other site 134676015957 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 134676015958 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 134676015959 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 134676015960 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 134676015961 23S rRNA binding site [nucleotide binding]; other site 134676015962 L21 binding site [polypeptide binding]; other site 134676015963 L13 binding site [polypeptide binding]; other site 134676015964 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 134676015965 translation initiation factor IF-3; Region: infC; TIGR00168 134676015966 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 134676015967 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 134676015968 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 134676015969 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 134676015970 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 134676015971 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 134676015972 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 134676015973 homodimer interface [polypeptide binding]; other site 134676015974 putative metal binding site [ion binding]; other site 134676015975 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 134676015976 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 134676015977 substrate binding pocket [chemical binding]; other site 134676015978 membrane-bound complex binding site; other site 134676015979 hinge residues; other site 134676015980 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 134676015981 dimer interface [polypeptide binding]; other site 134676015982 conserved gate region; other site 134676015983 putative PBP binding loops; other site 134676015984 ABC-ATPase subunit interface; other site 134676015985 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 134676015986 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 134676015987 Walker A/P-loop; other site 134676015988 ATP binding site [chemical binding]; other site 134676015989 Q-loop/lid; other site 134676015990 ABC transporter signature motif; other site 134676015991 Walker B; other site 134676015992 D-loop; other site 134676015993 H-loop/switch region; other site 134676015994 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 134676015995 homopentamer interface [polypeptide binding]; other site 134676015996 active site 134676015997 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 134676015998 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 134676015999 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 134676016000 dimerization interface [polypeptide binding]; other site 134676016001 active site 134676016002 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 134676016003 Lumazine binding domain; Region: Lum_binding; pfam00677 134676016004 Lumazine binding domain; Region: Lum_binding; pfam00677 134676016005 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 134676016006 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 134676016007 catalytic motif [active] 134676016008 Zn binding site [ion binding]; other site 134676016009 RibD C-terminal domain; Region: RibD_C; cl17279 134676016010 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 134676016011 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 134676016012 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 134676016013 catalytic residue [active] 134676016014 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 134676016015 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676016016 WHG domain; Region: WHG; pfam13305 134676016017 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 134676016018 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 134676016019 putative acyl-acceptor binding pocket; other site 134676016020 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676016021 active site 134676016022 phosphorylation site [posttranslational modification] 134676016023 intermolecular recognition site; other site 134676016024 dimerization interface [polypeptide binding]; other site 134676016025 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 134676016026 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676016027 metal binding site [ion binding]; metal-binding site 134676016028 active site 134676016029 I-site; other site 134676016030 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 134676016031 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 134676016032 hexamer interface [polypeptide binding]; other site 134676016033 metal binding site [ion binding]; metal-binding site 134676016034 substrate binding site [chemical binding]; other site 134676016035 16S rRNA methyltransferase B; Provisional; Region: PRK14902 134676016036 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 134676016037 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 134676016038 S-adenosylmethionine binding site [chemical binding]; other site 134676016039 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 134676016040 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 134676016041 putative active site [active] 134676016042 substrate binding site [chemical binding]; other site 134676016043 putative cosubstrate binding site; other site 134676016044 catalytic site [active] 134676016045 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 134676016046 substrate binding site [chemical binding]; other site 134676016047 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 134676016048 active site 134676016049 catalytic residues [active] 134676016050 metal binding site [ion binding]; metal-binding site 134676016051 primosome assembly protein PriA; Provisional; Region: PRK14873 134676016052 YgiT-type zinc finger domain; Region: YgiT_finger; TIGR03831 134676016053 S-adenosylmethionine synthetase; Validated; Region: PRK05250 134676016054 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 134676016055 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 134676016056 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 134676016057 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 134676016058 Flavoprotein; Region: Flavoprotein; pfam02441 134676016059 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 134676016060 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 134676016061 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 134676016062 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 134676016063 catalytic site [active] 134676016064 G-X2-G-X-G-K; other site 134676016065 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 134676016066 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 134676016067 active site 134676016068 dimer interface [polypeptide binding]; other site 134676016069 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 134676016070 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 134676016071 inhibitor-cofactor binding pocket; inhibition site 134676016072 pyridoxal 5'-phosphate binding site [chemical binding]; other site 134676016073 catalytic residue [active] 134676016074 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 134676016075 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 134676016076 quinone interaction residues [chemical binding]; other site 134676016077 active site 134676016078 catalytic residues [active] 134676016079 FMN binding site [chemical binding]; other site 134676016080 substrate binding site [chemical binding]; other site 134676016081 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 134676016082 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 134676016083 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 134676016084 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 134676016085 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 134676016086 ATP-grasp domain; Region: ATP-grasp_4; cl17255 134676016087 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 134676016088 IMP binding site; other site 134676016089 dimer interface [polypeptide binding]; other site 134676016090 interdomain contacts; other site 134676016091 partial ornithine binding site; other site 134676016092 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 134676016093 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 134676016094 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 134676016095 catalytic site [active] 134676016096 subunit interface [polypeptide binding]; other site 134676016097 dihydroorotase; Validated; Region: pyrC; PRK09357 134676016098 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 134676016099 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 134676016100 active site 134676016101 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 134676016102 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 134676016103 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 134676016104 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 134676016105 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 134676016106 active site 134676016107 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 134676016108 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 134676016109 non-specific DNA binding site [nucleotide binding]; other site 134676016110 salt bridge; other site 134676016111 sequence-specific DNA binding site [nucleotide binding]; other site 134676016112 transcription antitermination factor NusB; Region: nusB; TIGR01951 134676016113 elongation factor P; Validated; Region: PRK00529 134676016114 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 134676016115 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 134676016116 RNA binding site [nucleotide binding]; other site 134676016117 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 134676016118 RNA binding site [nucleotide binding]; other site 134676016119 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 134676016120 Dehydroquinase class II; Region: DHquinase_II; pfam01220 134676016121 trimer interface [polypeptide binding]; other site 134676016122 active site 134676016123 dimer interface [polypeptide binding]; other site 134676016124 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 134676016125 active site 134676016126 dimer interface [polypeptide binding]; other site 134676016127 metal binding site [ion binding]; metal-binding site 134676016128 shikimate kinase; Reviewed; Region: aroK; PRK00131 134676016129 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 134676016130 ADP binding site [chemical binding]; other site 134676016131 magnesium binding site [ion binding]; other site 134676016132 putative shikimate binding site; other site 134676016133 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 134676016134 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 134676016135 Tetramer interface [polypeptide binding]; other site 134676016136 active site 134676016137 FMN-binding site [chemical binding]; other site 134676016138 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 134676016139 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 134676016140 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 134676016141 NAD(P) binding site [chemical binding]; other site 134676016142 shikimate binding site; other site 134676016143 YceG-like family; Region: YceG; pfam02618 134676016144 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 134676016145 dimerization interface [polypeptide binding]; other site 134676016146 YceG-like family; Region: YceG; pfam02618 134676016147 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 134676016148 dimerization interface [polypeptide binding]; other site 134676016149 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 134676016150 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 134676016151 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 134676016152 motif 1; other site 134676016153 active site 134676016154 motif 2; other site 134676016155 motif 3; other site 134676016156 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 134676016157 recombination factor protein RarA; Reviewed; Region: PRK13342 134676016158 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 134676016159 Walker A motif; other site 134676016160 ATP binding site [chemical binding]; other site 134676016161 Walker B motif; other site 134676016162 arginine finger; other site 134676016163 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 134676016164 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 134676016165 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 134676016166 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 134676016167 dimer interface [polypeptide binding]; other site 134676016168 anticodon binding site; other site 134676016169 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 134676016170 homodimer interface [polypeptide binding]; other site 134676016171 motif 1; other site 134676016172 active site 134676016173 motif 2; other site 134676016174 GAD domain; Region: GAD; pfam02938 134676016175 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 134676016176 active site 134676016177 motif 3; other site 134676016178 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 134676016179 active site 134676016180 substrate binding site [chemical binding]; other site 134676016181 ATP binding site [chemical binding]; other site 134676016182 Tetratrico peptide repeat; Region: TPR_5; pfam12688 134676016183 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 134676016184 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 134676016185 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 134676016186 catalytic residue [active] 134676016187 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 134676016188 Phosphotransferase enzyme family; Region: APH; pfam01636 134676016189 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 134676016190 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 134676016191 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 134676016192 active site 134676016193 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 134676016194 putative DNA binding site [nucleotide binding]; other site 134676016195 putative Zn2+ binding site [ion binding]; other site 134676016196 dihydroorotase; Provisional; Region: PRK09237 134676016197 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 134676016198 active site 134676016199 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 134676016200 homotrimer interaction site [polypeptide binding]; other site 134676016201 putative active site [active] 134676016202 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 134676016203 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 134676016204 active site 134676016205 ATP binding site [chemical binding]; other site 134676016206 substrate binding site [chemical binding]; other site 134676016207 activation loop (A-loop); other site 134676016208 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 134676016209 alpha-gamma subunit interface [polypeptide binding]; other site 134676016210 beta-gamma subunit interface [polypeptide binding]; other site 134676016211 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 134676016212 gamma-beta subunit interface [polypeptide binding]; other site 134676016213 alpha-beta subunit interface [polypeptide binding]; other site 134676016214 urease subunit alpha; Reviewed; Region: ureC; PRK13206 134676016215 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 134676016216 active site 134676016217 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 134676016218 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH6; cd08260 134676016219 putative NAD(P) binding site [chemical binding]; other site 134676016220 catalytic Zn binding site [ion binding]; other site 134676016221 structural Zn binding site [ion binding]; other site 134676016222 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 134676016223 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 134676016224 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 134676016225 DNA binding residues [nucleotide binding] 134676016226 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 134676016227 Catalytic domain of Protein Kinases; Region: PKc; cd00180 134676016228 active site 134676016229 ATP binding site [chemical binding]; other site 134676016230 substrate binding site [chemical binding]; other site 134676016231 activation loop (A-loop); other site 134676016232 Cellulose binding domain; Region: CBM_2; cl17741 134676016233 cyanophycin synthetase; Provisional; Region: PRK14016 134676016234 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 134676016235 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 134676016236 proposed catalytic triad [active] 134676016237 active site nucleophile [active] 134676016238 Predicted transcriptional regulators [Transcription]; Region: COG1733 134676016239 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 134676016240 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 134676016241 CoenzymeA binding site [chemical binding]; other site 134676016242 subunit interaction site [polypeptide binding]; other site 134676016243 PHB binding site; other site 134676016244 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 134676016245 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 134676016246 dimer interface [polypeptide binding]; other site 134676016247 motif 1; other site 134676016248 active site 134676016249 motif 2; other site 134676016250 motif 3; other site 134676016251 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 134676016252 anticodon binding site; other site 134676016253 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 134676016254 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 134676016255 active site 134676016256 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 134676016257 active site 134676016258 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 134676016259 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 134676016260 Zn2+ binding site [ion binding]; other site 134676016261 Mg2+ binding site [ion binding]; other site 134676016262 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 134676016263 synthetase active site [active] 134676016264 NTP binding site [chemical binding]; other site 134676016265 metal binding site [ion binding]; metal-binding site 134676016266 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 134676016267 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 134676016268 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 134676016269 active site 134676016270 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 134676016271 Protein export membrane protein; Region: SecD_SecF; cl14618 134676016272 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 134676016273 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 134676016274 Preprotein translocase subunit; Region: YajC; pfam02699 134676016275 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 134676016276 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 134676016277 Walker A motif; other site 134676016278 ATP binding site [chemical binding]; other site 134676016279 Walker B motif; other site 134676016280 arginine finger; other site 134676016281 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 134676016282 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 134676016283 RuvA N terminal domain; Region: RuvA_N; pfam01330 134676016284 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 134676016285 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 134676016286 active site 134676016287 putative DNA-binding cleft [nucleotide binding]; other site 134676016288 dimer interface [polypeptide binding]; other site 134676016289 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 134676016290 putative active site [active] 134676016291 hypothetical protein; Validated; Region: PRK00110 134676016292 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 134676016293 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181 134676016294 predicted active site [active] 134676016295 catalytic triad [active] 134676016296 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 134676016297 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 134676016298 active site 134676016299 multimer interface [polypeptide binding]; other site 134676016300 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 134676016301 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 134676016302 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 134676016303 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 134676016304 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 134676016305 putative acyl-acceptor binding pocket; other site 134676016306 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 134676016307 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 134676016308 elongation factor G; Reviewed; Region: PRK12740 134676016309 G1 box; other site 134676016310 putative GEF interaction site [polypeptide binding]; other site 134676016311 GTP/Mg2+ binding site [chemical binding]; other site 134676016312 Switch I region; other site 134676016313 G2 box; other site 134676016314 G3 box; other site 134676016315 Switch II region; other site 134676016316 G4 box; other site 134676016317 G5 box; other site 134676016318 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 134676016319 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 134676016320 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 134676016321 hypothetical protein; Provisional; Region: PRK07236 134676016322 hypothetical protein; Validated; Region: PRK05868 134676016323 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 134676016324 nucleotide binding site/active site [active] 134676016325 HIT family signature motif; other site 134676016326 catalytic residue [active] 134676016327 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 134676016328 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 134676016329 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 134676016330 active site 134676016331 dimer interface [polypeptide binding]; other site 134676016332 motif 1; other site 134676016333 motif 2; other site 134676016334 motif 3; other site 134676016335 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 134676016336 anticodon binding site; other site 134676016337 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 134676016338 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676016339 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 134676016340 active site 134676016341 phosphorylation site [posttranslational modification] 134676016342 intermolecular recognition site; other site 134676016343 dimerization interface [polypeptide binding]; other site 134676016344 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 134676016345 DNA binding site [nucleotide binding] 134676016346 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 134676016347 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 134676016348 dimerization interface [polypeptide binding]; other site 134676016349 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 134676016350 dimer interface [polypeptide binding]; other site 134676016351 phosphorylation site [posttranslational modification] 134676016352 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 134676016353 ATP binding site [chemical binding]; other site 134676016354 Mg2+ binding site [ion binding]; other site 134676016355 G-X-G motif; other site 134676016356 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 134676016357 Ricin-type beta-trefoil lectin domain-like; Region: RicinB_lectin_2; pfam14200 134676016358 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 134676016359 adenosine deaminase; Provisional; Region: PRK09358 134676016360 active site 134676016361 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 134676016362 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 134676016363 S-adenosylmethionine binding site [chemical binding]; other site 134676016364 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 134676016365 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 134676016366 active site 134676016367 catalytic tetrad [active] 134676016368 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 134676016369 DNA-binding site [nucleotide binding]; DNA binding site 134676016370 RNA-binding motif; other site 134676016371 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 134676016372 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 134676016373 Mechanosensitive ion channel; Region: MS_channel; pfam00924 134676016374 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 134676016375 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 134676016376 Predicted acetyltransferase [General function prediction only]; Region: COG2388 134676016377 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 134676016378 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 134676016379 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 134676016380 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 134676016381 ATP binding site [chemical binding]; other site 134676016382 putative Mg++ binding site [ion binding]; other site 134676016383 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 134676016384 nucleotide binding region [chemical binding]; other site 134676016385 ATP-binding site [chemical binding]; other site 134676016386 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 134676016387 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 134676016388 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 134676016389 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 134676016390 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 134676016391 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 134676016392 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 134676016393 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676016394 active site 134676016395 phosphorylation site [posttranslational modification] 134676016396 intermolecular recognition site; other site 134676016397 dimerization interface [polypeptide binding]; other site 134676016398 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 134676016399 DNA binding residues [nucleotide binding] 134676016400 dimerization interface [polypeptide binding]; other site 134676016401 Histidine kinase; Region: HisKA_3; pfam07730 134676016402 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 134676016403 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676016404 ATP binding site [chemical binding]; other site 134676016405 Mg2+ binding site [ion binding]; other site 134676016406 G-X-G motif; other site 134676016407 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 134676016408 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 134676016409 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 134676016410 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 134676016411 Walker A/P-loop; other site 134676016412 ATP binding site [chemical binding]; other site 134676016413 Q-loop/lid; other site 134676016414 ABC transporter signature motif; other site 134676016415 Walker B; other site 134676016416 D-loop; other site 134676016417 H-loop/switch region; other site 134676016418 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 134676016419 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 134676016420 putative ADP-binding pocket [chemical binding]; other site 134676016421 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 134676016422 hydrophobic ligand binding site; other site 134676016423 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 134676016424 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 134676016425 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 134676016426 putative hydrophobic ligand binding site [chemical binding]; other site 134676016427 CBD_II domain; Region: CBD_II; smart00637 134676016428 PAS fold; Region: PAS_4; pfam08448 134676016429 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 134676016430 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 134676016431 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 134676016432 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 134676016433 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 134676016434 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 134676016435 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 134676016436 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 134676016437 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 134676016438 MarR family; Region: MarR_2; pfam12802 134676016439 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 134676016440 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 134676016441 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 134676016442 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 134676016443 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 134676016444 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 134676016445 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 134676016446 active site 134676016447 ATP binding site [chemical binding]; other site 134676016448 substrate binding site [chemical binding]; other site 134676016449 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 134676016450 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 134676016451 active site 134676016452 Pirin-related protein [General function prediction only]; Region: COG1741 134676016453 Pirin; Region: Pirin; pfam02678 134676016454 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 134676016455 Clp amino terminal domain; Region: Clp_N; pfam02861 134676016456 Clp amino terminal domain; Region: Clp_N; pfam02861 134676016457 putative transcriptional regulator; Provisional; Region: tfx; cl17550 134676016458 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 134676016459 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 134676016460 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 134676016461 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 134676016462 putative active site [active] 134676016463 catalytic site [active] 134676016464 Catalytic domain, repeat 2, of vertebrate phospholipases, PLD1 and PLD2, and similar proteins; Region: PLDc_vPLD1_2_like_2; cd09105 134676016465 putative active site [active] 134676016466 catalytic site [active] 134676016467 Putative sensor; Region: Sensor; pfam13796 134676016468 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 134676016469 Histidine kinase; Region: HisKA_3; pfam07730 134676016470 transcriptional regulator NarP; Provisional; Region: PRK10403 134676016471 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676016472 active site 134676016473 phosphorylation site [posttranslational modification] 134676016474 intermolecular recognition site; other site 134676016475 dimerization interface [polypeptide binding]; other site 134676016476 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 134676016477 DNA binding residues [nucleotide binding] 134676016478 dimerization interface [polypeptide binding]; other site 134676016479 protein-L-isoaspartate O-methyltransferase; Provisional; Region: PRK13944 134676016480 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 134676016481 S-adenosylmethionine binding site [chemical binding]; other site 134676016482 Phosphotransferase enzyme family; Region: APH; pfam01636 134676016483 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 134676016484 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 134676016485 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 134676016486 malate synthase A; Region: malate_syn_A; TIGR01344 134676016487 active site 134676016488 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 134676016489 active site 134676016490 homotetramer interface [polypeptide binding]; other site 134676016491 HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643 134676016492 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 134676016493 putative Mg++ binding site [ion binding]; other site 134676016494 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 134676016495 nucleotide binding region [chemical binding]; other site 134676016496 ATP-binding site [chemical binding]; other site 134676016497 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 134676016498 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 134676016499 S-adenosylmethionine binding site [chemical binding]; other site 134676016500 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 134676016501 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676016502 metal binding site [ion binding]; metal-binding site 134676016503 active site 134676016504 I-site; other site 134676016505 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676016506 I-site; other site 134676016507 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 134676016508 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 134676016509 active site 134676016510 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 134676016511 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 134676016512 substrate binding pocket [chemical binding]; other site 134676016513 membrane-bound complex binding site; other site 134676016514 hinge residues; other site 134676016515 Haemolytic domain; Region: Haemolytic; pfam01809 134676016516 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 134676016517 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 134676016518 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 134676016519 catalytic site [active] 134676016520 active site 134676016521 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 134676016522 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 134676016523 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 134676016524 active site 134676016525 catalytic site [active] 134676016526 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 134676016527 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 134676016528 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 134676016529 active site 134676016530 catalytic site [active] 134676016531 Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439 134676016532 glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561 134676016533 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 134676016534 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 134676016535 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 134676016536 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 134676016537 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 134676016538 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 134676016539 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 134676016540 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 134676016541 Fibronectin type 3 domain; Region: FN3; smart00060 134676016542 PAC2 family; Region: PAC2; pfam09754 134676016543 S-formylglutathione hydrolase; Region: PLN02442 134676016544 Putative esterase; Region: Esterase; pfam00756 134676016545 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 134676016546 EamA-like transporter family; Region: EamA; pfam00892 134676016547 56kDa selenium binding protein (SBP56); Region: SBP56; pfam05694 134676016548 PAS fold; Region: PAS; pfam00989 134676016549 PAS domain; Region: PAS; smart00091 134676016550 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 134676016551 putative active site [active] 134676016552 heme pocket [chemical binding]; other site 134676016553 GAF domain; Region: GAF_2; pfam13185 134676016554 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 134676016555 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 134676016556 dimer interface [polypeptide binding]; other site 134676016557 phosphorylation site [posttranslational modification] 134676016558 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676016559 ATP binding site [chemical binding]; other site 134676016560 Mg2+ binding site [ion binding]; other site 134676016561 G-X-G motif; other site 134676016562 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 134676016563 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 134676016564 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 134676016565 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 134676016566 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 134676016567 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 134676016568 TAP-like protein; Region: Abhydrolase_4; pfam08386 134676016569 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u2; cd11478 134676016570 Na binding site [ion binding]; other site 134676016571 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 134676016572 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 134676016573 hypothetical protein; Provisional; Region: PRK07588 134676016574 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 134676016575 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 134676016576 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 134676016577 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 134676016578 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 134676016579 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 134676016580 glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554 134676016581 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 134676016582 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 134676016583 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 134676016584 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 134676016585 Glycosyl hydrolase catalytic core; Region: Glyco_hydro_cc; pfam11790 134676016586 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 134676016587 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676016588 ATP binding site [chemical binding]; other site 134676016589 Mg2+ binding site [ion binding]; other site 134676016590 G-X-G motif; other site 134676016591 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 134676016592 MarR family; Region: MarR_2; cl17246 134676016593 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 134676016594 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 134676016595 Lsr2; Region: Lsr2; pfam11774 134676016596 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 134676016597 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 134676016598 Protein of unknown function (DUF456); Region: DUF456; pfam04306 134676016599 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 134676016600 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 134676016601 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 134676016602 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 134676016603 DNA binding residues [nucleotide binding] 134676016604 Methyltransferase domain; Region: Methyltransf_23; pfam13489 134676016605 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 134676016606 S-adenosylmethionine binding site [chemical binding]; other site 134676016607 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 134676016608 Family description; Region: UvrD_C_2; pfam13538 134676016609 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 134676016610 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 134676016611 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 134676016612 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 134676016613 DNA binding residues [nucleotide binding] 134676016614 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 134676016615 DEAD-like helicases superfamily; Region: DEXDc; smart00487 134676016616 ATP binding site [chemical binding]; other site 134676016617 putative Mg++ binding site [ion binding]; other site 134676016618 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 134676016619 nucleotide binding region [chemical binding]; other site 134676016620 ATP-binding site [chemical binding]; other site 134676016621 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 134676016622 Uncharacterized conserved protein [Function unknown]; Region: COG4850 134676016623 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 134676016624 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 134676016625 Transcriptional regulators [Transcription]; Region: PurR; COG1609 134676016626 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 134676016627 DNA binding site [nucleotide binding] 134676016628 domain linker motif; other site 134676016629 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 134676016630 dimerization interface [polypeptide binding]; other site 134676016631 ligand binding site [chemical binding]; other site 134676016632 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 134676016633 substrate binding site [chemical binding]; other site 134676016634 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 134676016635 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 134676016636 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 134676016637 Walker A/P-loop; other site 134676016638 ATP binding site [chemical binding]; other site 134676016639 Q-loop/lid; other site 134676016640 ABC transporter signature motif; other site 134676016641 Walker B; other site 134676016642 D-loop; other site 134676016643 H-loop/switch region; other site 134676016644 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 134676016645 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 134676016646 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 134676016647 dimer interface [polypeptide binding]; other site 134676016648 conserved gate region; other site 134676016649 putative PBP binding loops; other site 134676016650 ABC-ATPase subunit interface; other site 134676016651 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 134676016652 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 134676016653 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 134676016654 dimer interface [polypeptide binding]; other site 134676016655 conserved gate region; other site 134676016656 putative PBP binding loops; other site 134676016657 ABC-ATPase subunit interface; other site 134676016658 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 134676016659 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 134676016660 Walker A/P-loop; other site 134676016661 ATP binding site [chemical binding]; other site 134676016662 Q-loop/lid; other site 134676016663 ABC transporter signature motif; other site 134676016664 Walker B; other site 134676016665 D-loop; other site 134676016666 H-loop/switch region; other site 134676016667 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 134676016668 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 134676016669 beta-galactosidase; Region: BGL; TIGR03356 134676016670 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 134676016671 S-adenosylmethionine binding site [chemical binding]; other site 134676016672 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 134676016673 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 134676016674 active site 134676016675 catalytic tetrad [active] 134676016676 Cupin domain; Region: Cupin_2; pfam07883 134676016677 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 134676016678 putative DNA binding site [nucleotide binding]; other site 134676016679 putative Zn2+ binding site [ion binding]; other site 134676016680 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 134676016681 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 134676016682 CAP-like domain; other site 134676016683 active site 134676016684 primary dimer interface [polypeptide binding]; other site 134676016685 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 134676016686 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 134676016687 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 134676016688 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676016689 ATP binding site [chemical binding]; other site 134676016690 Mg2+ binding site [ion binding]; other site 134676016691 G-X-G motif; other site 134676016692 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 134676016693 anchoring element; other site 134676016694 dimer interface [polypeptide binding]; other site 134676016695 ATP binding site [chemical binding]; other site 134676016696 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 134676016697 active site 134676016698 metal binding site [ion binding]; metal-binding site 134676016699 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 134676016700 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 134676016701 cyclase homology domain; Region: CHD; cd07302 134676016702 nucleotidyl binding site; other site 134676016703 metal binding site [ion binding]; metal-binding site 134676016704 dimer interface [polypeptide binding]; other site 134676016705 AAA ATPase domain; Region: AAA_16; pfam13191 134676016706 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 134676016707 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 134676016708 DNA binding residues [nucleotide binding] 134676016709 dimerization interface [polypeptide binding]; other site 134676016710 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 134676016711 dimer interface [polypeptide binding]; other site 134676016712 phosphorylation site [posttranslational modification] 134676016713 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 134676016714 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 134676016715 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676016716 active site 134676016717 phosphorylation site [posttranslational modification] 134676016718 intermolecular recognition site; other site 134676016719 dimerization interface [polypeptide binding]; other site 134676016720 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 134676016721 DNA binding site [nucleotide binding] 134676016722 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 134676016723 active site 134676016724 catalytic site [active] 134676016725 substrate binding site [chemical binding]; other site 134676016726 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cl00038 134676016727 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 134676016728 MarR family; Region: MarR_2; cl17246 134676016729 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 134676016730 EamA-like transporter family; Region: EamA; pfam00892 134676016731 EamA-like transporter family; Region: EamA; pfam00892 134676016732 SWIM zinc finger; Region: SWIM; pfam04434 134676016733 MoxR-like ATPases [General function prediction only]; Region: COG0714 134676016734 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 134676016735 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 134676016736 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 134676016737 metal ion-dependent adhesion site (MIDAS); other site 134676016738 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 134676016739 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 134676016740 active site 134676016741 catalytic triad [active] 134676016742 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 134676016743 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 134676016744 IPT/TIG domain; Region: TIG; pfam01833 134676016745 IPT/TIG domain; Region: TIG; pfam01833 134676016746 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 134676016747 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 134676016748 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 134676016749 nudix motif; other site 134676016750 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 134676016751 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 134676016752 active site 134676016753 substrate binding site [chemical binding]; other site 134676016754 ATP binding site [chemical binding]; other site 134676016755 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 134676016756 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 134676016757 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 134676016758 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 134676016759 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 134676016760 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 134676016761 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 134676016762 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 134676016763 Walker A motif; other site 134676016764 ATP binding site [chemical binding]; other site 134676016765 Walker B motif; other site 134676016766 arginine finger; other site 134676016767 Domain of unknown function (DUF385); Region: DUF385; pfam04075 134676016768 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 134676016769 active site 134676016770 catalytic triad [active] 134676016771 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 134676016772 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 134676016773 Moco binding site; other site 134676016774 metal coordination site [ion binding]; other site 134676016775 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 134676016776 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_3; cd06217 134676016777 FAD binding pocket [chemical binding]; other site 134676016778 FAD binding motif [chemical binding]; other site 134676016779 phosphate binding motif [ion binding]; other site 134676016780 beta-alpha-beta structure motif; other site 134676016781 NAD binding pocket [chemical binding]; other site 134676016782 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 134676016783 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 134676016784 calcium binding site 2 [ion binding]; other site 134676016785 active site 134676016786 catalytic triad [active] 134676016787 calcium binding site 1 [ion binding]; other site 134676016788 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 134676016789 Melibiase; Region: Melibiase; pfam02065 134676016790 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 134676016791 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 134676016792 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 134676016793 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 134676016794 dimer interface [polypeptide binding]; other site 134676016795 conserved gate region; other site 134676016796 putative PBP binding loops; other site 134676016797 ABC-ATPase subunit interface; other site 134676016798 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 134676016799 dimer interface [polypeptide binding]; other site 134676016800 conserved gate region; other site 134676016801 ABC-ATPase subunit interface; other site 134676016802 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 134676016803 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 134676016804 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 134676016805 Transcriptional regulators [Transcription]; Region: PurR; COG1609 134676016806 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 134676016807 DNA binding site [nucleotide binding] 134676016808 domain linker motif; other site 134676016809 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 134676016810 putative dimerization interface [polypeptide binding]; other site 134676016811 putative ligand binding site [chemical binding]; other site 134676016812 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 134676016813 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676016814 active site 134676016815 phosphorylation site [posttranslational modification] 134676016816 intermolecular recognition site; other site 134676016817 dimerization interface [polypeptide binding]; other site 134676016818 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 134676016819 DNA binding residues [nucleotide binding] 134676016820 dimerization interface [polypeptide binding]; other site 134676016821 Putative sensor; Region: Sensor; pfam13796 134676016822 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 134676016823 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 134676016824 FtsX-like permease family; Region: FtsX; pfam02687 134676016825 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 134676016826 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 134676016827 Walker A/P-loop; other site 134676016828 ATP binding site [chemical binding]; other site 134676016829 Q-loop/lid; other site 134676016830 ABC transporter signature motif; other site 134676016831 Walker B; other site 134676016832 D-loop; other site 134676016833 H-loop/switch region; other site 134676016834 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 134676016835 active site 134676016836 catalytic triad [active] 134676016837 oxyanion hole [active] 134676016838 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 134676016839 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 134676016840 Catalytic domain of Protein Kinases; Region: PKc; cd00180 134676016841 active site 134676016842 ATP binding site [chemical binding]; other site 134676016843 substrate binding site [chemical binding]; other site 134676016844 activation loop (A-loop); other site 134676016845 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 134676016846 PAS domain; Region: PAS_9; pfam13426 134676016847 putative active site [active] 134676016848 heme pocket [chemical binding]; other site 134676016849 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 134676016850 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 134676016851 dimer interface [polypeptide binding]; other site 134676016852 phosphorylation site [posttranslational modification] 134676016853 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676016854 ATP binding site [chemical binding]; other site 134676016855 Mg2+ binding site [ion binding]; other site 134676016856 G-X-G motif; other site 134676016857 Response regulator receiver domain; Region: Response_reg; pfam00072 134676016858 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676016859 active site 134676016860 phosphorylation site [posttranslational modification] 134676016861 intermolecular recognition site; other site 134676016862 dimerization interface [polypeptide binding]; other site 134676016863 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 134676016864 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 134676016865 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 134676016866 active site 134676016867 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 134676016868 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 134676016869 Walker A/P-loop; other site 134676016870 ATP binding site [chemical binding]; other site 134676016871 Q-loop/lid; other site 134676016872 ABC transporter signature motif; other site 134676016873 Walker B; other site 134676016874 D-loop; other site 134676016875 H-loop/switch region; other site 134676016876 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 134676016877 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 134676016878 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 134676016879 Walker A/P-loop; other site 134676016880 ATP binding site [chemical binding]; other site 134676016881 Q-loop/lid; other site 134676016882 ABC transporter signature motif; other site 134676016883 Walker B; other site 134676016884 D-loop; other site 134676016885 H-loop/switch region; other site 134676016886 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 134676016887 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 134676016888 oligomer interface [polypeptide binding]; other site 134676016889 metal binding site [ion binding]; metal-binding site 134676016890 metal binding site [ion binding]; metal-binding site 134676016891 putative Cl binding site [ion binding]; other site 134676016892 aspartate ring; other site 134676016893 basic sphincter; other site 134676016894 hydrophobic gate; other site 134676016895 periplasmic entrance; other site 134676016896 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 134676016897 Benzoate membrane transport protein; Region: BenE; pfam03594 134676016898 benzoate transporter; Region: benE; TIGR00843 134676016899 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 134676016900 Major Facilitator Superfamily; Region: MFS_1; pfam07690 134676016901 putative substrate translocation pore; other site 134676016902 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 134676016903 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676016904 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 134676016905 RNA polymerase factor sigma-70; Validated; Region: PRK08241 134676016906 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 134676016907 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 134676016908 DNA binding residues [nucleotide binding] 134676016909 SnoaL-like domain; Region: SnoaL_2; pfam12680 134676016910 aminotransferase AlaT; Validated; Region: PRK09265 134676016911 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 134676016912 pyridoxal 5'-phosphate binding site [chemical binding]; other site 134676016913 homodimer interface [polypeptide binding]; other site 134676016914 catalytic residue [active] 134676016915 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 134676016916 protein-splicing catalytic site; other site 134676016917 thioester formation/cholesterol transfer; other site 134676016918 Pretoxin HINT domain; Region: PT-HINT; pfam07591 134676016919 Peptidase domain in the S53 family; Region: Peptidases_S53_like; cd05562 134676016920 putative active site [active] 134676016921 putative catalytic triad [active] 134676016922 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 134676016923 catalytic residues [active] 134676016924 Regulatory P domain of the subtilisin-like proprotein convertases and other proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG4935 134676016925 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 134676016926 MarR family; Region: MarR_2; cl17246 134676016927 EVE domain; Region: EVE; cl00728 134676016928 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 134676016929 hydrophobic ligand binding site; other site 134676016930 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 134676016931 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676016932 Domain of unknown function (DUF4142); Region: DUF4142; cl17876 134676016933 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 134676016934 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 134676016935 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 134676016936 active site 134676016937 catalytic triad [active] 134676016938 oxyanion hole [active] 134676016939 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 134676016940 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 134676016941 Walker A/P-loop; other site 134676016942 ATP binding site [chemical binding]; other site 134676016943 Q-loop/lid; other site 134676016944 ABC transporter signature motif; other site 134676016945 Walker B; other site 134676016946 D-loop; other site 134676016947 H-loop/switch region; other site 134676016948 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 134676016949 FtsX-like permease family; Region: FtsX; pfam02687 134676016950 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 134676016951 Predicted esterase [General function prediction only]; Region: COG0627 134676016952 Winged helix-turn helix; Region: HTH_29; pfam13551 134676016953 Homeodomain-like domain; Region: HTH_32; pfam13565 134676016954 DDE superfamily endonuclease; Region: DDE_3; pfam13358 134676016955 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 134676016956 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 134676016957 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 134676016958 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 134676016959 active site 134676016960 DNA binding site [nucleotide binding] 134676016961 Int/Topo IB signature motif; other site 134676016962 Putative transmembrane protein (PGPGW); Region: PGPGW; cl09870 134676016963 Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686 134676016964 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 134676016965 Transcriptional regulator; Region: Rrf2; pfam02082 134676016966 Rrf2 family protein; Region: rrf2_super; TIGR00738 134676016967 Protein of unknown function (DUF4236); Region: DUF4236; pfam14020 134676016968 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 134676016969 Interdomain contacts; other site 134676016970 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 134676016971 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676016972 metal binding site [ion binding]; metal-binding site 134676016973 active site 134676016974 I-site; other site 134676016975 Protein of unknown function (DUF664); Region: DUF664; pfam04978 134676016976 DinB superfamily; Region: DinB_2; pfam12867 134676016977 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 134676016978 Transglutaminase-like superfamily; Region: Transglut_core; cl17362 134676016979 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 134676016980 putative catalytic site [active] 134676016981 putative metal binding site [ion binding]; other site 134676016982 putative phosphate binding site [ion binding]; other site 134676016983 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 134676016984 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 134676016985 active site 134676016986 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 134676016987 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 134676016988 active site 134676016989 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 134676016990 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 134676016991 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 134676016992 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 134676016993 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 134676016994 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 134676016995 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 134676016996 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 134676016997 DNA binding site [nucleotide binding] 134676016998 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 134676016999 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 134676017000 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 134676017001 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 134676017002 calcium binding site 2 [ion binding]; other site 134676017003 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 134676017004 active site 134676017005 catalytic triad [active] 134676017006 calcium binding site 1 [ion binding]; other site 134676017007 Putative Ig domain; Region: He_PIG; pfam05345 134676017008 Putative Ig domain; Region: He_PIG; pfam05345 134676017009 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 134676017010 Response regulator receiver domain; Region: Response_reg; pfam00072 134676017011 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676017012 active site 134676017013 phosphorylation site [posttranslational modification] 134676017014 intermolecular recognition site; other site 134676017015 dimerization interface [polypeptide binding]; other site 134676017016 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 134676017017 DNA binding residues [nucleotide binding] 134676017018 Histidine kinase; Region: HisKA_3; pfam07730 134676017019 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 134676017020 Domain of unknown function (DUF4281); Region: DUF4281; pfam14108 134676017021 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 134676017022 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 134676017023 conserved cys residue [active] 134676017024 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 134676017025 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 134676017026 Isochorismatase family; Region: Isochorismatase; pfam00857 134676017027 catalytic triad [active] 134676017028 conserved cis-peptide bond; other site 134676017029 First Helix-Turn-Helix DNA binding domain of the regulatory protein TioE; Region: HTH_TioE_rpt1; cd04772 134676017030 DNA binding residues [nucleotide binding] 134676017031 putative dimer interface [polypeptide binding]; other site 134676017032 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 134676017033 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 134676017034 DNA binding residues [nucleotide binding] 134676017035 PRC-barrel domain; Region: PRC; pfam05239 134676017036 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 134676017037 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 134676017038 substrate binding site [chemical binding]; other site 134676017039 ATP binding site [chemical binding]; other site 134676017040 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 134676017041 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 134676017042 active site 134676017043 intersubunit interface [polypeptide binding]; other site 134676017044 catalytic residue [active] 134676017045 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 134676017046 DNA-binding site [nucleotide binding]; DNA binding site 134676017047 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676017048 hypothetical protein; Provisional; Region: PRK07236 134676017049 hypothetical protein; Validated; Region: PRK05868 134676017050 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 134676017051 amidase catalytic site [active] 134676017052 Zn binding residues [ion binding]; other site 134676017053 substrate binding site [chemical binding]; other site 134676017054 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 134676017055 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 134676017056 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 134676017057 Ca binding site [ion binding]; other site 134676017058 active site 134676017059 catalytic site [active] 134676017060 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 134676017061 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 134676017062 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 134676017063 putative ADP-binding pocket [chemical binding]; other site 134676017064 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 134676017065 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 134676017066 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 134676017067 active site 134676017068 hypothetical protein; Provisional; Region: PRK08317 134676017069 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 134676017070 S-adenosylmethionine binding site [chemical binding]; other site 134676017071 putative oxidoreductase; Provisional; Region: PRK11579 134676017072 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 134676017073 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 134676017074 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 134676017075 active site 134676017076 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 134676017077 kynureninase; Region: kynureninase; TIGR01814 134676017078 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 134676017079 catalytic residue [active] 134676017080 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 134676017081 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012 134676017082 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 134676017083 putative CheW interface [polypeptide binding]; other site 134676017084 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 134676017085 Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231 134676017086 sugar binding site [chemical binding]; other site 134676017087 CARDB; Region: CARDB; pfam07705 134676017088 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 134676017089 putative metal binding site [ion binding]; other site 134676017090 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 134676017091 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 134676017092 putative metal binding site [ion binding]; other site 134676017093 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 134676017094 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 134676017095 Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231 134676017096 sugar binding site [chemical binding]; other site 134676017097 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 134676017098 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 134676017099 active site 134676017100 catalytic site [active] 134676017101 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 134676017102 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 134676017103 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 134676017104 dimer interface [polypeptide binding]; other site 134676017105 conserved gate region; other site 134676017106 putative PBP binding loops; other site 134676017107 ABC-ATPase subunit interface; other site 134676017108 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 134676017109 dimer interface [polypeptide binding]; other site 134676017110 conserved gate region; other site 134676017111 putative PBP binding loops; other site 134676017112 ABC-ATPase subunit interface; other site 134676017113 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 134676017114 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 134676017115 Transcriptional regulators [Transcription]; Region: PurR; COG1609 134676017116 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 134676017117 DNA binding site [nucleotide binding] 134676017118 domain linker motif; other site 134676017119 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_10; cd06292 134676017120 putative dimerization interface [polypeptide binding]; other site 134676017121 putative ligand binding site [chemical binding]; other site 134676017122 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 134676017123 Sulfate transporter family; Region: Sulfate_transp; pfam00916 134676017124 CDP-tyvelose 2-epimerase, extended (e) SDRs; Region: CDP_TE_SDR_e; cd05258 134676017125 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 134676017126 NAD binding site [chemical binding]; other site 134676017127 homotetramer interface [polypeptide binding]; other site 134676017128 homodimer interface [polypeptide binding]; other site 134676017129 active site 134676017130 substrate binding site [chemical binding]; other site 134676017131 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 134676017132 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 134676017133 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 134676017134 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 134676017135 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 134676017136 active site 134676017137 dimer interface [polypeptide binding]; other site 134676017138 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 134676017139 Ligand Binding Site [chemical binding]; other site 134676017140 Molecular Tunnel; other site 134676017141 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 134676017142 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 134676017143 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 134676017144 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 134676017145 putative substrate translocation pore; other site 134676017146 Major Facilitator Superfamily; Region: MFS_1; pfam07690 134676017147 DinB superfamily; Region: DinB_2; pfam12867 134676017148 Protein of unknown function (DUF664); Region: DUF664; pfam04978 134676017149 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 134676017150 Leucine carboxyl methyltransferase; Region: LCM; cl01306 134676017151 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 134676017152 putative hydrophobic ligand binding site [chemical binding]; other site 134676017153 protein interface [polypeptide binding]; other site 134676017154 gate; other site 134676017155 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 134676017156 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 134676017157 ligand binding site [chemical binding]; other site 134676017158 flexible hinge region; other site 134676017159 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676017160 ATP binding site [chemical binding]; other site 134676017161 Mg2+ binding site [ion binding]; other site 134676017162 G-X-G motif; other site 134676017163 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 134676017164 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676017165 active site 134676017166 phosphorylation site [posttranslational modification] 134676017167 intermolecular recognition site; other site 134676017168 dimerization interface [polypeptide binding]; other site 134676017169 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 134676017170 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 134676017171 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 134676017172 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 134676017173 ATP-NAD kinase; Region: NAD_kinase; pfam01513 134676017174 Predicted acetyltransferase [General function prediction only]; Region: COG2388 134676017175 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 134676017176 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 134676017177 Methyltransferase domain; Region: Methyltransf_31; pfam13847 134676017178 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 134676017179 S-adenosylmethionine binding site [chemical binding]; other site 134676017180 Protein of unknown function (DUF1684); Region: DUF1684; pfam07920 134676017181 Adenosylcobinamide amidohydrolase; Region: CbiZ; pfam01955 134676017182 Sulfatase; Region: Sulfatase; cl17466 134676017183 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 134676017184 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676017185 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 134676017186 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 134676017187 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 134676017188 Walker A/P-loop; other site 134676017189 ATP binding site [chemical binding]; other site 134676017190 Q-loop/lid; other site 134676017191 ABC transporter signature motif; other site 134676017192 Walker B; other site 134676017193 D-loop; other site 134676017194 H-loop/switch region; other site 134676017195 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 134676017196 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 134676017197 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 134676017198 Walker A/P-loop; other site 134676017199 ATP binding site [chemical binding]; other site 134676017200 Q-loop/lid; other site 134676017201 ABC transporter signature motif; other site 134676017202 Walker B; other site 134676017203 D-loop; other site 134676017204 H-loop/switch region; other site 134676017205 Calx-beta domain; Region: Calx-beta; cl02522 134676017206 Calx-beta domain; Region: Calx-beta; cl02522 134676017207 Calx-beta domain; Region: Calx-beta; pfam03160 134676017208 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 134676017209 Alkaline phosphatase homologues; Region: alkPPc; smart00098 134676017210 active site 134676017211 dimer interface [polypeptide binding]; other site 134676017212 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 134676017213 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676017214 active site 134676017215 phosphorylation site [posttranslational modification] 134676017216 intermolecular recognition site; other site 134676017217 dimerization interface [polypeptide binding]; other site 134676017218 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 134676017219 DNA binding residues [nucleotide binding] 134676017220 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 134676017221 Histidine kinase; Region: HisKA_3; pfam07730 134676017222 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676017223 ATP binding site [chemical binding]; other site 134676017224 G-X-G motif; other site 134676017225 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 134676017226 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 134676017227 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 134676017228 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 134676017229 Walker A/P-loop; other site 134676017230 ATP binding site [chemical binding]; other site 134676017231 Q-loop/lid; other site 134676017232 ABC transporter signature motif; other site 134676017233 Walker B; other site 134676017234 D-loop; other site 134676017235 H-loop/switch region; other site 134676017236 ABC-2 type transporter; Region: ABC2_membrane; cl17235 134676017237 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 134676017238 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 134676017239 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 134676017240 Walker A/P-loop; other site 134676017241 ATP binding site [chemical binding]; other site 134676017242 Q-loop/lid; other site 134676017243 ABC transporter signature motif; other site 134676017244 Walker B; other site 134676017245 D-loop; other site 134676017246 H-loop/switch region; other site 134676017247 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 134676017248 RNA/DNA hybrid binding site [nucleotide binding]; other site 134676017249 active site 134676017250 MarR family; Region: MarR_2; cl17246 134676017251 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 134676017252 TIGR03086 family protein; Region: TIGR03086 134676017253 Protein of unknown function (DUF419); Region: DUF419; cl15265 134676017254 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 134676017255 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 134676017256 DNA binding residues [nucleotide binding] 134676017257 dimerization interface [polypeptide binding]; other site 134676017258 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 134676017259 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 134676017260 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 134676017261 nucleotide binding site [chemical binding]; other site 134676017262 Histidine kinase; Region: HisKA_3; pfam07730 134676017263 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 134676017264 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 134676017265 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676017266 active site 134676017267 phosphorylation site [posttranslational modification] 134676017268 intermolecular recognition site; other site 134676017269 dimerization interface [polypeptide binding]; other site 134676017270 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 134676017271 DNA binding residues [nucleotide binding] 134676017272 dimerization interface [polypeptide binding]; other site 134676017273 PAS domain S-box; Region: sensory_box; TIGR00229 134676017274 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 134676017275 putative active site [active] 134676017276 heme pocket [chemical binding]; other site 134676017277 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 134676017278 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676017279 active site 134676017280 I-site; other site 134676017281 metal binding site [ion binding]; metal-binding site 134676017282 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 134676017283 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 134676017284 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 134676017285 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 134676017286 metal binding site [ion binding]; metal-binding site 134676017287 ligand binding site [chemical binding]; other site 134676017288 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 134676017289 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 134676017290 putative dimer interface [polypeptide binding]; other site 134676017291 DNA polymerase IV; Validated; Region: PRK03858 134676017292 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 134676017293 active site 134676017294 DNA binding site [nucleotide binding] 134676017295 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 134676017296 DNA-binding site [nucleotide binding]; DNA binding site 134676017297 RNA-binding motif; other site 134676017298 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 134676017299 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 134676017300 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 134676017301 DNA binding residues [nucleotide binding] 134676017302 BNR repeat-like domain; Region: BNR_2; pfam13088 134676017303 VPS10 domain; Region: VPS10; smart00602 134676017304 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 134676017305 active site 134676017306 SAM binding site [chemical binding]; other site 134676017307 homodimer interface [polypeptide binding]; other site 134676017308 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 134676017309 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 134676017310 Uncharacterized conserved protein [Function unknown]; Region: COG2128 134676017311 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 134676017312 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 134676017313 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 134676017314 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 134676017315 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 134676017316 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 134676017317 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 134676017318 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 134676017319 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 134676017320 Precorrin-8X methylmutase; Region: CbiC; pfam02570 134676017321 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 134676017322 homodimer interface [polypeptide binding]; other site 134676017323 SAM binding site [chemical binding]; other site 134676017324 active site 134676017325 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 134676017326 active site 134676017327 SAM binding site [chemical binding]; other site 134676017328 homodimer interface [polypeptide binding]; other site 134676017329 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 134676017330 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 134676017331 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 134676017332 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 134676017333 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 134676017334 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 134676017335 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 134676017336 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 134676017337 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 134676017338 Ligand binding site; other site 134676017339 Putative Catalytic site; other site 134676017340 DXD motif; other site 134676017341 legume lectins; Region: lectin_L-type; cd01951 134676017342 homotetramer interaction site [polypeptide binding]; other site 134676017343 carbohydrate binding site [chemical binding]; other site 134676017344 metal binding site [ion binding]; metal-binding site 134676017345 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 134676017346 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 134676017347 FAD binding pocket [chemical binding]; other site 134676017348 FAD binding motif [chemical binding]; other site 134676017349 phosphate binding motif [ion binding]; other site 134676017350 NAD binding pocket [chemical binding]; other site 134676017351 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 134676017352 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 134676017353 putative substrate translocation pore; other site 134676017354 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 134676017355 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 134676017356 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 134676017357 FOG: WD40 repeat [General function prediction only]; Region: COG2319 134676017358 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 134676017359 structural tetrad; other site 134676017360 FOG: WD40 repeat [General function prediction only]; Region: COG2319 134676017361 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 134676017362 structural tetrad; other site 134676017363 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 134676017364 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 134676017365 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 134676017366 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 134676017367 motif II; other site 134676017368 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 134676017369 homodimer interface [polypeptide binding]; other site 134676017370 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 134676017371 active site pocket [active] 134676017372 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 134676017373 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 134676017374 DNA binding residues [nucleotide binding] 134676017375 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 134676017376 Walker A/P-loop; other site 134676017377 ATP binding site [chemical binding]; other site 134676017378 Q-loop/lid; other site 134676017379 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 134676017380 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 134676017381 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539 134676017382 Walker A/P-loop; other site 134676017383 ATP binding site [chemical binding]; other site 134676017384 Q-loop/lid; other site 134676017385 ABC transporter signature motif; other site 134676017386 Walker B; other site 134676017387 D-loop; other site 134676017388 H-loop/switch region; other site 134676017389 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 134676017390 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cl15820 134676017391 putative sugar binding sites [chemical binding]; other site 134676017392 Q-X-W motif; other site 134676017393 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 134676017394 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 134676017395 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 134676017396 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 134676017397 anti sigma factor interaction site; other site 134676017398 regulatory phosphorylation site [posttranslational modification]; other site 134676017399 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 134676017400 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 134676017401 active site 134676017402 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676 134676017403 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 134676017404 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 134676017405 Caspase domain; Region: Peptidase_C14; pfam00656 134676017406 Part of AAA domain; Region: AAA_19; pfam13245 134676017407 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 134676017408 AAA domain; Region: AAA_12; pfam13087 134676017409 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 134676017410 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 134676017411 active site 134676017412 RHS Repeat; Region: RHS_repeat; pfam05593 134676017413 RHS Repeat; Region: RHS_repeat; pfam05593 134676017414 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 134676017415 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 134676017416 Family description; Region: VCBS; pfam13517 134676017417 Family description; Region: VCBS; pfam13517 134676017418 Winged helix-turn helix; Region: HTH_29; pfam13551 134676017419 Homeodomain-like domain; Region: HTH_32; pfam13565 134676017420 DDE superfamily endonuclease; Region: DDE_3; pfam13358 134676017421 Astacin (Peptidase family M12A); Region: Astacin; pfam01400 134676017422 Zinc-dependent metalloprotease, astacin_like subfamily or peptidase family M12A, a group of zinc-dependent proteolytic enzymes with a HExxH zinc-binding site/active site. Members of this family may have an amino terminal propeptide, which is cleaved to...; Region: ZnMc_astacin_like; cd04280 134676017423 active site 134676017424 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 134676017425 MoxR-like ATPases [General function prediction only]; Region: COG0714 134676017426 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 134676017427 Walker A motif; other site 134676017428 ATP binding site [chemical binding]; other site 134676017429 Walker B motif; other site 134676017430 arginine finger; other site 134676017431 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 134676017432 Protein of unknown function DUF58; Region: DUF58; pfam01882 134676017433 Aerotolerance regulator N-terminal; Region: BatA; cl06567 134676017434 von Willebrand factor type A domain; Region: VWA_2; pfam13519 134676017435 metal ion-dependent adhesion site (MIDAS); other site 134676017436 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 134676017437 metal ion-dependent adhesion site (MIDAS); other site 134676017438 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 134676017439 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 134676017440 G1 box; other site 134676017441 GTP/Mg2+ binding site [chemical binding]; other site 134676017442 G2 box; other site 134676017443 Switch I region; other site 134676017444 G3 box; other site 134676017445 Switch II region; other site 134676017446 Protein of unknown function (DUF742); Region: DUF742; pfam05331 134676017447 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 134676017448 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676017449 ATP binding site [chemical binding]; other site 134676017450 Mg2+ binding site [ion binding]; other site 134676017451 G-X-G motif; other site 134676017452 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 134676017453 Catalytic site [active] 134676017454 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 134676017455 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 134676017456 Walker A/P-loop; other site 134676017457 ATP binding site [chemical binding]; other site 134676017458 Q-loop/lid; other site 134676017459 ABC transporter signature motif; other site 134676017460 Walker B; other site 134676017461 D-loop; other site 134676017462 H-loop/switch region; other site 134676017463 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 134676017464 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 134676017465 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 134676017466 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 134676017467 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 134676017468 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 134676017469 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 134676017470 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 134676017471 Tetratricopeptide repeat; Region: TPR_12; pfam13424 134676017472 Tetratricopeptide repeat; Region: TPR_10; pfam13374 134676017473 Tetratricopeptide repeat; Region: TPR_12; pfam13424 134676017474 Tetratricopeptide repeat; Region: TPR_10; pfam13374 134676017475 Tetratricopeptide repeat; Region: TPR_12; pfam13424 134676017476 Tetratricopeptide repeat; Region: TPR_10; pfam13374 134676017477 Tetratricopeptide repeat; Region: TPR_10; pfam13374 134676017478 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 134676017479 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 134676017480 substrate binding pocket [chemical binding]; other site 134676017481 Predicted transcriptional regulator [Transcription]; Region: COG2378 134676017482 HTH domain; Region: HTH_11; pfam08279 134676017483 WYL domain; Region: WYL; pfam13280 134676017484 legume lectins; Region: lectin_L-type; cd01951 134676017485 homotetramer interaction site [polypeptide binding]; other site 134676017486 carbohydrate binding site [chemical binding]; other site 134676017487 metal binding site [ion binding]; metal-binding site 134676017488 Domain of unknown function (DUF397); Region: DUF397; pfam04149 134676017489 Tetratricopeptide repeat; Region: TPR_12; pfam13424 134676017490 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 134676017491 binding surface 134676017492 TPR motif; other site 134676017493 Tetratricopeptide repeat; Region: TPR_12; pfam13424 134676017494 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 134676017495 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 134676017496 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 134676017497 DNA binding residues [nucleotide binding] 134676017498 Predicted transcriptional regulators [Transcription]; Region: COG1695 134676017499 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 134676017500 Winged helix-turn helix; Region: HTH_29; pfam13551 134676017501 Homeodomain-like domain; Region: HTH_32; pfam13565 134676017502 DDE superfamily endonuclease; Region: DDE_3; pfam13358 134676017503 hypothetical protein; Provisional; Region: PRK01346 134676017504 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 134676017505 Coenzyme A binding pocket [chemical binding]; other site 134676017506 ApbE family; Region: ApbE; pfam02424 134676017507 FMN-binding domain; Region: FMN_bind; cl01081 134676017508 Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097 134676017509 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 134676017510 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 134676017511 FAD binding pocket [chemical binding]; other site 134676017512 FAD binding motif [chemical binding]; other site 134676017513 phosphate binding motif [ion binding]; other site 134676017514 beta-alpha-beta structure motif; other site 134676017515 NAD binding pocket [chemical binding]; other site 134676017516 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 134676017517 active site 134676017518 putative homodimer interface [polypeptide binding]; other site 134676017519 SAM binding site [chemical binding]; other site 134676017520 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 134676017521 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 134676017522 S-adenosylmethionine binding site [chemical binding]; other site 134676017523 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 134676017524 active site 134676017525 SAM binding site [chemical binding]; other site 134676017526 homodimer interface [polypeptide binding]; other site 134676017527 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 134676017528 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 134676017529 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676017530 metal binding site [ion binding]; metal-binding site 134676017531 active site 134676017532 I-site; other site 134676017533 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 134676017534 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 134676017535 catalytic residue [active] 134676017536 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 134676017537 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 134676017538 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 134676017539 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 134676017540 IucA / IucC family; Region: IucA_IucC; pfam04183 134676017541 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 134676017542 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 134676017543 active site 134676017544 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 134676017545 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 134676017546 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 134676017547 TAP-like protein; Region: Abhydrolase_4; pfam08386 134676017548 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 134676017549 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 134676017550 conserved cys residue [active] 134676017551 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 134676017552 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 134676017553 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 134676017554 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676017555 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 134676017556 Beta-galactosidase, domain 2; Region: BetaGal_dom2; smart01029 134676017557 Beta-galactosidase, domain 2; Region: BetaGal_dom2; smart01029 134676017558 Beta-galactosidase, domain 3; Region: BetaGal_dom3; pfam13363 134676017559 Beta-galactosidase jelly roll domain; Region: BetaGal_dom4_5; pfam13364 134676017560 Beta-galactosidase jelly roll domain; Region: BetaGal_dom4_5; pfam13364 134676017561 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 134676017562 NPCBM/NEW2 domain; Region: NPCBM; pfam08305 134676017563 glycoside hydrolase family 64: laminaripentaose-producing, beta-1,3-glucanase (LPHase)-like; Region: GH64-LPHase-like; cd09216 134676017564 substrate binding pocket [chemical binding]; other site 134676017565 catalytic residues [active] 134676017566 Cellulose binding domain; Region: CBM_2; pfam00553 134676017567 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 134676017568 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 134676017569 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 134676017570 Transcriptional regulators [Transcription]; Region: PurR; COG1609 134676017571 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 134676017572 DNA binding site [nucleotide binding] 134676017573 domain linker motif; other site 134676017574 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 134676017575 ligand binding site [chemical binding]; other site 134676017576 dimerization interface [polypeptide binding]; other site 134676017577 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 134676017578 nucleotide binding site [chemical binding]; other site 134676017579 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 134676017580 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 134676017581 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 134676017582 active site 134676017583 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 134676017584 PAS domain S-box; Region: sensory_box; TIGR00229 134676017585 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 134676017586 putative active site [active] 134676017587 heme pocket [chemical binding]; other site 134676017588 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 134676017589 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676017590 metal binding site [ion binding]; metal-binding site 134676017591 active site 134676017592 I-site; other site 134676017593 Predicted membrane protein [Function unknown]; Region: COG4425 134676017594 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 134676017595 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 134676017596 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 134676017597 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676017598 active site 134676017599 phosphorylation site [posttranslational modification] 134676017600 intermolecular recognition site; other site 134676017601 dimerization interface [polypeptide binding]; other site 134676017602 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 134676017603 DNA binding residues [nucleotide binding] 134676017604 dimerization interface [polypeptide binding]; other site 134676017605 Putative sensor; Region: Sensor; pfam13796 134676017606 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 134676017607 Histidine kinase; Region: HisKA_3; pfam07730 134676017608 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 134676017609 putative di-iron ligands [ion binding]; other site 134676017610 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 134676017611 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 134676017612 active site 134676017613 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 134676017614 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 134676017615 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 134676017616 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 134676017617 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 134676017618 substrate-cofactor binding pocket; other site 134676017619 pyridoxal 5'-phosphate binding site [chemical binding]; other site 134676017620 catalytic residue [active] 134676017621 MMPL family; Region: MMPL; pfam03176 134676017622 MMPL family; Region: MMPL; pfam03176 134676017623 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 134676017624 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 134676017625 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 134676017626 acyl-activating enzyme (AAE) consensus motif; other site 134676017627 AMP binding site [chemical binding]; other site 134676017628 active site 134676017629 CoA binding site [chemical binding]; other site 134676017630 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 134676017631 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 134676017632 hydroxyglutarate oxidase; Provisional; Region: PRK11728 134676017633 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 134676017634 Lsr2; Region: Lsr2; pfam11774 134676017635 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 134676017636 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 134676017637 NAD(P) binding site [chemical binding]; other site 134676017638 active site 134676017639 PAS domain S-box; Region: sensory_box; TIGR00229 134676017640 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 134676017641 putative active site [active] 134676017642 heme pocket [chemical binding]; other site 134676017643 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 134676017644 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676017645 metal binding site [ion binding]; metal-binding site 134676017646 active site 134676017647 I-site; other site 134676017648 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 134676017649 Predicted methyltransferase [General function prediction only]; Region: COG3897 134676017650 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 134676017651 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 134676017652 motif II; other site 134676017653 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 134676017654 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 134676017655 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 134676017656 nucleotide binding site [chemical binding]; other site 134676017657 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 134676017658 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 134676017659 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 134676017660 catalytic residue [active] 134676017661 biotin synthase; Validated; Region: PRK06256 134676017662 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 134676017663 FeS/SAM binding site; other site 134676017664 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 134676017665 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cd02116 134676017666 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 134676017667 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 134676017668 hypothetical protein; Provisional; Region: PRK14059 134676017669 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 134676017670 HerA helicase [Replication, recombination, and repair]; Region: COG0433 134676017671 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 134676017672 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 134676017673 active site 134676017674 metal binding site [ion binding]; metal-binding site 134676017675 DNA binding site [nucleotide binding] 134676017676 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 134676017677 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 134676017678 AAA domain; Region: AAA_23; pfam13476 134676017679 Walker A/P-loop; other site 134676017680 ATP binding site [chemical binding]; other site 134676017681 Q-loop/lid; other site 134676017682 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 134676017683 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 134676017684 ABC transporter signature motif; other site 134676017685 Walker B; other site 134676017686 D-loop; other site 134676017687 H-loop/switch region; other site 134676017688 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2380 134676017689 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 134676017690 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 134676017691 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 134676017692 DNA binding residues [nucleotide binding] 134676017693 Putative zinc-finger; Region: zf-HC2; pfam13490 134676017694 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 134676017695 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 134676017696 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 134676017697 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 134676017698 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 134676017699 helix-hairpin-helix signature motif; other site 134676017700 active site 134676017701 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 134676017702 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl17465 134676017703 Aminoglycoside-2''-adenylyltransferase; Region: Aminoglyc_resit; pfam10706 134676017704 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 134676017705 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 134676017706 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 134676017707 dGTP triphosphohydrolase [Nucleotide transport and metabolism]; Region: Dgt; COG0232 134676017708 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 134676017709 Zn2+ binding site [ion binding]; other site 134676017710 Mg2+ binding site [ion binding]; other site 134676017711 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 134676017712 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 134676017713 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676017714 Phospholipid methyltransferase; Region: PEMT; cl17370 134676017715 Protein of unknown function (DUF3037); Region: DUF3037; pfam11236 134676017716 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 134676017717 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 134676017718 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 134676017719 active site 134676017720 DNA binding site [nucleotide binding] 134676017721 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 134676017722 DNA binding site [nucleotide binding] 134676017723 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 134676017724 TAP-like protein; Region: Abhydrolase_4; pfam08386 134676017725 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 134676017726 Coenzyme A binding pocket [chemical binding]; other site 134676017727 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 134676017728 nucleotide binding site [chemical binding]; other site 134676017729 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 134676017730 SelR domain; Region: SelR; pfam01641 134676017731 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 134676017732 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 134676017733 folate binding site [chemical binding]; other site 134676017734 NADP+ binding site [chemical binding]; other site 134676017735 thymidylate synthase; Reviewed; Region: thyA; PRK01827 134676017736 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 134676017737 dimerization interface [polypeptide binding]; other site 134676017738 active site 134676017739 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 134676017740 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 134676017741 N-terminal Early set domain associated with the catalytic domain of isoamylase-like (also called glycogen 6-glucanohydrolase) proteins; Region: E_set_Isoamylase_like_N; cd07184 134676017742 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 134676017743 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 134676017744 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 134676017745 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 134676017746 substrate binding site [chemical binding]; other site 134676017747 active site 134676017748 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 134676017749 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 134676017750 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 134676017751 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 134676017752 catalytic site [active] 134676017753 putative active site [active] 134676017754 putative substrate binding site [chemical binding]; other site 134676017755 Helicase and RNase D C-terminal; Region: HRDC; smart00341 134676017756 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 134676017757 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 134676017758 dimer interface [polypeptide binding]; other site 134676017759 active site 134676017760 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 134676017761 substrate binding site [chemical binding]; other site 134676017762 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 134676017763 oxyanion hole (OAH) forming residues; other site 134676017764 trimer interface [polypeptide binding]; other site 134676017765 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 134676017766 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 134676017767 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 134676017768 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 134676017769 dimerization interface [polypeptide binding]; other site 134676017770 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 134676017771 dimer interface [polypeptide binding]; other site 134676017772 phosphorylation site [posttranslational modification] 134676017773 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676017774 ATP binding site [chemical binding]; other site 134676017775 Mg2+ binding site [ion binding]; other site 134676017776 G-X-G motif; other site 134676017777 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 134676017778 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676017779 active site 134676017780 phosphorylation site [posttranslational modification] 134676017781 intermolecular recognition site; other site 134676017782 dimerization interface [polypeptide binding]; other site 134676017783 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 134676017784 DNA binding site [nucleotide binding] 134676017785 PQQ-like domain; Region: PQQ_2; pfam13360 134676017786 PQQ-like domain; Region: PQQ_2; pfam13360 134676017787 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 134676017788 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 134676017789 TPP-binding site; other site 134676017790 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 134676017791 PYR/PP interface [polypeptide binding]; other site 134676017792 dimer interface [polypeptide binding]; other site 134676017793 TPP binding site [chemical binding]; other site 134676017794 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 134676017795 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 134676017796 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 134676017797 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 134676017798 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 134676017799 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 134676017800 homodimer interface [polypeptide binding]; other site 134676017801 NADP binding site [chemical binding]; other site 134676017802 substrate binding site [chemical binding]; other site 134676017803 TRAM domain; Region: TRAM; pfam01938 134676017804 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 134676017805 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 134676017806 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 134676017807 TrkA-N domain; Region: TrkA_N; pfam02254 134676017808 TrkA-C domain; Region: TrkA_C; pfam02080 134676017809 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 134676017810 TrkA-N domain; Region: TrkA_N; pfam02254 134676017811 TrkA-C domain; Region: TrkA_C; pfam02080 134676017812 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 134676017813 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 134676017814 ssDNA binding site; other site 134676017815 generic binding surface II; other site 134676017816 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 134676017817 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 134676017818 trimer interface [polypeptide binding]; other site 134676017819 active site 134676017820 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 134676017821 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 134676017822 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 134676017823 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 134676017824 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 134676017825 active site 134676017826 dimerization interface [polypeptide binding]; other site 134676017827 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 134676017828 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 134676017829 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 134676017830 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 134676017831 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 134676017832 DNA binding residues [nucleotide binding] 134676017833 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 134676017834 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676017835 metal binding site [ion binding]; metal-binding site 134676017836 active site 134676017837 I-site; other site 134676017838 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 134676017839 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 134676017840 ATP binding site [chemical binding]; other site 134676017841 putative Mg++ binding site [ion binding]; other site 134676017842 UPF0126 domain; Region: UPF0126; pfam03458 134676017843 Predicted membrane protein [Function unknown]; Region: COG2860 134676017844 UPF0126 domain; Region: UPF0126; pfam03458 134676017845 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 134676017846 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 134676017847 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 134676017848 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 134676017849 substrate binding site [chemical binding]; other site 134676017850 ATP binding site [chemical binding]; other site 134676017851 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 134676017852 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 134676017853 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 134676017854 GAF domain; Region: GAF; pfam01590 134676017855 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 134676017856 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 134676017857 dimer interface [polypeptide binding]; other site 134676017858 putative CheW interface [polypeptide binding]; other site 134676017859 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 134676017860 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676017861 active site 134676017862 phosphorylation site [posttranslational modification] 134676017863 intermolecular recognition site; other site 134676017864 dimerization interface [polypeptide binding]; other site 134676017865 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 134676017866 putative binding surface; other site 134676017867 active site 134676017868 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 134676017869 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676017870 ATP binding site [chemical binding]; other site 134676017871 Mg2+ binding site [ion binding]; other site 134676017872 G-X-G motif; other site 134676017873 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 134676017874 Response regulator receiver domain; Region: Response_reg; pfam00072 134676017875 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676017876 active site 134676017877 phosphorylation site [posttranslational modification] 134676017878 intermolecular recognition site; other site 134676017879 dimerization interface [polypeptide binding]; other site 134676017880 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 134676017881 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 134676017882 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 134676017883 S-adenosylmethionine binding site [chemical binding]; other site 134676017884 HEAT repeats; Region: HEAT_2; pfam13646 134676017885 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 134676017886 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676017887 active site 134676017888 phosphorylation site [posttranslational modification] 134676017889 intermolecular recognition site; other site 134676017890 dimerization interface [polypeptide binding]; other site 134676017891 CheB methylesterase; Region: CheB_methylest; pfam01339 134676017892 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 134676017893 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 134676017894 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 134676017895 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 134676017896 dimer interface [polypeptide binding]; other site 134676017897 putative CheW interface [polypeptide binding]; other site 134676017898 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 134676017899 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 134676017900 dimer interface [polypeptide binding]; other site 134676017901 putative CheW interface [polypeptide binding]; other site 134676017902 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 134676017903 putative active site [active] 134676017904 dimerization interface [polypeptide binding]; other site 134676017905 putative tRNAtyr binding site [nucleotide binding]; other site 134676017906 SpoOM protein; Region: Spo0M; pfam07070 134676017907 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 134676017908 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 134676017909 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 134676017910 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 134676017911 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 134676017912 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 134676017913 DNA binding residues [nucleotide binding] 134676017914 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 134676017915 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 134676017916 Coenzyme A binding pocket [chemical binding]; other site 134676017917 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 134676017918 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 134676017919 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 134676017920 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 134676017921 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 134676017922 active site 134676017923 Zn binding site [ion binding]; other site 134676017924 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 134676017925 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 134676017926 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 134676017927 FeoA domain; Region: FeoA; pfam04023 134676017928 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 134676017929 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 134676017930 Major Facilitator Superfamily; Region: MFS_1; pfam07690 134676017931 vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556 134676017932 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 134676017933 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 134676017934 active site 134676017935 dimer interface [polypeptide binding]; other site 134676017936 effector binding site; other site 134676017937 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 134676017938 TSCPD domain; Region: TSCPD; pfam12637 134676017939 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 134676017940 ATP cone domain; Region: ATP-cone; pfam03477 134676017941 LexA repressor; Validated; Region: PRK00215 134676017942 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 134676017943 putative DNA binding site [nucleotide binding]; other site 134676017944 putative Zn2+ binding site [ion binding]; other site 134676017945 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 134676017946 Catalytic site [active] 134676017947 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 134676017948 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 134676017949 HflX GTPase family; Region: HflX; cd01878 134676017950 G1 box; other site 134676017951 GTP/Mg2+ binding site [chemical binding]; other site 134676017952 Switch I region; other site 134676017953 G2 box; other site 134676017954 G3 box; other site 134676017955 Switch II region; other site 134676017956 G4 box; other site 134676017957 G5 box; other site 134676017958 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 134676017959 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 134676017960 Malic enzyme, N-terminal domain; Region: malic; pfam00390 134676017961 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 134676017962 putative NAD(P) binding site [chemical binding]; other site 134676017963 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 134676017964 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 134676017965 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 134676017966 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 134676017967 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 134676017968 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 134676017969 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 134676017970 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 134676017971 TrkA-N domain; Region: TrkA_N; pfam02254 134676017972 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 134676017973 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 134676017974 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 134676017975 catalytic residue [active] 134676017976 Transcriptional regulator [Transcription]; Region: LysR; COG0583 134676017977 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 134676017978 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 134676017979 putative dimerization interface [polypeptide binding]; other site 134676017980 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 134676017981 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 134676017982 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 134676017983 DNA binding residues [nucleotide binding] 134676017984 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 134676017985 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 134676017986 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 134676017987 FeS/SAM binding site; other site 134676017988 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 134676017989 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 134676017990 Walker A/P-loop; other site 134676017991 ATP binding site [chemical binding]; other site 134676017992 Q-loop/lid; other site 134676017993 ABC transporter signature motif; other site 134676017994 Walker B; other site 134676017995 D-loop; other site 134676017996 H-loop/switch region; other site 134676017997 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 134676017998 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 134676017999 substrate binding pocket [chemical binding]; other site 134676018000 membrane-bound complex binding site; other site 134676018001 hinge residues; other site 134676018002 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 134676018003 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 134676018004 dimer interface [polypeptide binding]; other site 134676018005 conserved gate region; other site 134676018006 putative PBP binding loops; other site 134676018007 ABC-ATPase subunit interface; other site 134676018008 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 134676018009 dimer interface [polypeptide binding]; other site 134676018010 conserved gate region; other site 134676018011 putative PBP binding loops; other site 134676018012 ABC-ATPase subunit interface; other site 134676018013 Domain of unknown function (DUF3552); Region: DUF3552; pfam12072 134676018014 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 134676018015 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 134676018016 Zn2+ binding site [ion binding]; other site 134676018017 Mg2+ binding site [ion binding]; other site 134676018018 RecX family; Region: RecX; pfam02631 134676018019 recombinase A; Provisional; Region: recA; PRK09354 134676018020 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 134676018021 hexamer interface [polypeptide binding]; other site 134676018022 Walker A motif; other site 134676018023 ATP binding site [chemical binding]; other site 134676018024 Walker B motif; other site 134676018025 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 134676018026 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 134676018027 Fe-S cluster binding site [ion binding]; other site 134676018028 active site 134676018029 transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481 134676018030 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 134676018031 DNA-binding site [nucleotide binding]; DNA binding site 134676018032 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 134676018033 pyridoxal 5'-phosphate binding site [chemical binding]; other site 134676018034 homodimer interface [polypeptide binding]; other site 134676018035 catalytic residue [active] 134676018036 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 134676018037 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 134676018038 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 134676018039 leucine export protein LeuE; Provisional; Region: PRK10958 134676018040 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 134676018041 Catalytic domain of Protein Kinases; Region: PKc; cd00180 134676018042 active site 134676018043 ATP binding site [chemical binding]; other site 134676018044 substrate binding site [chemical binding]; other site 134676018045 activation loop (A-loop); other site 134676018046 DEAD-like helicases superfamily; Region: DEXDc; smart00487 134676018047 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 134676018048 ATP binding site [chemical binding]; other site 134676018049 putative Mg++ binding site [ion binding]; other site 134676018050 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 134676018051 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 134676018052 nucleotide binding region [chemical binding]; other site 134676018053 ATP-binding site [chemical binding]; other site 134676018054 DEAD/H associated; Region: DEAD_assoc; pfam08494 134676018055 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 134676018056 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 134676018057 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 134676018058 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 134676018059 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 134676018060 putative DNA binding site [nucleotide binding]; other site 134676018061 catalytic residue [active] 134676018062 putative H2TH interface [polypeptide binding]; other site 134676018063 putative catalytic residues [active] 134676018064 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 134676018065 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 134676018066 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 134676018067 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 134676018068 non-specific DNA binding site [nucleotide binding]; other site 134676018069 salt bridge; other site 134676018070 sequence-specific DNA binding site [nucleotide binding]; other site 134676018071 Competence-damaged protein; Region: CinA; pfam02464 134676018072 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 134676018073 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 134676018074 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 134676018075 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 134676018076 FeS/SAM binding site; other site 134676018077 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 134676018078 dimerization interface [polypeptide binding]; other site 134676018079 Predicted transcriptional regulator [Transcription]; Region: COG2345 134676018080 putative DNA binding site [nucleotide binding]; other site 134676018081 putative Zn2+ binding site [ion binding]; other site 134676018082 Domain of unknown function (DUF3291); Region: DUF3291; pfam11695 134676018083 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 134676018084 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 134676018085 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 134676018086 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 134676018087 Alpha-lytic protease prodomain; Region: Pro_Al_protease; pfam02983 134676018088 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 134676018089 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 134676018090 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 134676018091 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 134676018092 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 134676018093 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 134676018094 dimer interface [polypeptide binding]; other site 134676018095 active site 134676018096 catalytic residue [active] 134676018097 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 134676018098 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 134676018099 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 134676018100 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 134676018101 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 134676018102 Coenzyme A binding pocket [chemical binding]; other site 134676018103 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 134676018104 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 134676018105 DNA-binding site [nucleotide binding]; DNA binding site 134676018106 RNA-binding motif; other site 134676018107 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 134676018108 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 134676018109 DNA binding residues [nucleotide binding] 134676018110 dihydrodipicolinate reductase; Provisional; Region: PRK00048 134676018111 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 134676018112 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 134676018113 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 134676018114 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 134676018115 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 134676018116 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 134676018117 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 134676018118 RNase E interface [polypeptide binding]; other site 134676018119 trimer interface [polypeptide binding]; other site 134676018120 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 134676018121 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 134676018122 RNase E interface [polypeptide binding]; other site 134676018123 trimer interface [polypeptide binding]; other site 134676018124 active site 134676018125 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 134676018126 putative nucleic acid binding region [nucleotide binding]; other site 134676018127 G-X-X-G motif; other site 134676018128 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 134676018129 RNA binding site [nucleotide binding]; other site 134676018130 domain interface; other site 134676018131 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 134676018132 16S/18S rRNA binding site [nucleotide binding]; other site 134676018133 S13e-L30e interaction site [polypeptide binding]; other site 134676018134 25S rRNA binding site [nucleotide binding]; other site 134676018135 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 134676018136 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 134676018137 active site 134676018138 Riboflavin kinase; Region: Flavokinase; pfam01687 134676018139 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 134676018140 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 134676018141 dimer interface [polypeptide binding]; other site 134676018142 phosphorylation site [posttranslational modification] 134676018143 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676018144 ATP binding site [chemical binding]; other site 134676018145 Mg2+ binding site [ion binding]; other site 134676018146 G-X-G motif; other site 134676018147 Response regulator receiver domain; Region: Response_reg; pfam00072 134676018148 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676018149 active site 134676018150 phosphorylation site [posttranslational modification] 134676018151 intermolecular recognition site; other site 134676018152 dimerization interface [polypeptide binding]; other site 134676018153 Response regulator receiver domain; Region: Response_reg; pfam00072 134676018154 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676018155 active site 134676018156 phosphorylation site [posttranslational modification] 134676018157 intermolecular recognition site; other site 134676018158 Response regulator receiver domain; Region: Response_reg; pfam00072 134676018159 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676018160 active site 134676018161 phosphorylation site [posttranslational modification] 134676018162 intermolecular recognition site; other site 134676018163 dimerization interface [polypeptide binding]; other site 134676018164 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 134676018165 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 134676018166 RNA binding site [nucleotide binding]; other site 134676018167 active site 134676018168 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 134676018169 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 134676018170 putative efflux protein, MATE family; Region: matE; TIGR00797 134676018171 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 134676018172 DHH family; Region: DHH; pfam01368 134676018173 DHHA1 domain; Region: DHHA1; pfam02272 134676018174 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 134676018175 Protein of unknown function (DUF503); Region: DUF503; pfam04456 134676018176 Methyltransferase domain; Region: Methyltransf_26; pfam13659 134676018177 translation initiation factor IF-2; Region: IF-2; TIGR00487 134676018178 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 134676018179 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 134676018180 G1 box; other site 134676018181 putative GEF interaction site [polypeptide binding]; other site 134676018182 GTP/Mg2+ binding site [chemical binding]; other site 134676018183 Switch I region; other site 134676018184 G2 box; other site 134676018185 G3 box; other site 134676018186 Switch II region; other site 134676018187 G4 box; other site 134676018188 G5 box; other site 134676018189 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 134676018190 Translation-initiation factor 2; Region: IF-2; pfam11987 134676018191 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 134676018192 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 134676018193 NusA N-terminal domain; Region: NusA_N; pfam08529 134676018194 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 134676018195 RNA binding site [nucleotide binding]; other site 134676018196 homodimer interface [polypeptide binding]; other site 134676018197 NusA-like KH domain; Region: KH_5; pfam13184 134676018198 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 134676018199 G-X-X-G motif; other site 134676018200 ribosome maturation protein RimP; Reviewed; Region: PRK00092 134676018201 Sm and related proteins; Region: Sm_like; cl00259 134676018202 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 134676018203 dinuclear metal binding motif [ion binding]; other site 134676018204 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 134676018205 active site 134676018206 NTP binding site [chemical binding]; other site 134676018207 metal binding triad [ion binding]; metal-binding site 134676018208 antibiotic binding site [chemical binding]; other site 134676018209 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 134676018210 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 134676018211 active site 134676018212 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 134676018213 anti sigma factor interaction site; other site 134676018214 regulatory phosphorylation site [posttranslational modification]; other site 134676018215 PAS fold; Region: PAS_4; pfam08448 134676018216 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 134676018217 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 134676018218 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 134676018219 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 134676018220 ATP binding site [chemical binding]; other site 134676018221 Mg2+ binding site [ion binding]; other site 134676018222 G-X-G motif; other site 134676018223 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 134676018224 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 134676018225 catalytic triad [active] 134676018226 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 134676018227 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 134676018228 catalytic triad [active] 134676018229 short chain dehydrogenase; Provisional; Region: PRK06057 134676018230 classical (c) SDRs; Region: SDR_c; cd05233 134676018231 NAD(P) binding site [chemical binding]; other site 134676018232 active site 134676018233 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 134676018234 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 134676018235 NAD(P) binding site [chemical binding]; other site 134676018236 catalytic residues [active] 134676018237 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 134676018238 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 134676018239 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 134676018240 amino acid permease (GABA permease); Region: 2A0304; TIGR00907 134676018241 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cd00413 134676018242 active site 134676018243 catalytic residues [active] 134676018244 Family description; Region: VCBS; pfam13517 134676018245 Family description; Region: VCBS; pfam13517 134676018246 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 134676018247 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 134676018248 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 134676018249 Walker A/P-loop; other site 134676018250 ATP binding site [chemical binding]; other site 134676018251 Q-loop/lid; other site 134676018252 ABC transporter signature motif; other site 134676018253 Walker B; other site 134676018254 D-loop; other site 134676018255 H-loop/switch region; other site 134676018256 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 134676018257 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 134676018258 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676018259 active site 134676018260 phosphorylation site [posttranslational modification] 134676018261 intermolecular recognition site; other site 134676018262 dimerization interface [polypeptide binding]; other site 134676018263 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 134676018264 DNA binding residues [nucleotide binding] 134676018265 dimerization interface [polypeptide binding]; other site 134676018266 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 134676018267 Histidine kinase; Region: HisKA_3; pfam07730 134676018268 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 134676018269 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 134676018270 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 134676018271 DNA binding residues [nucleotide binding] 134676018272 dimer interface [polypeptide binding]; other site 134676018273 Helix-turn-helix domain; Region: HTH_31; pfam13560 134676018274 sequence-specific DNA binding site [nucleotide binding]; other site 134676018275 salt bridge; other site 134676018276 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 134676018277 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676018278 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 134676018279 Predicted membrane protein [Function unknown]; Region: COG1511 134676018280 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 134676018281 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 134676018282 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 134676018283 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 134676018284 Walker A/P-loop; other site 134676018285 ATP binding site [chemical binding]; other site 134676018286 Q-loop/lid; other site 134676018287 ABC transporter signature motif; other site 134676018288 Walker B; other site 134676018289 D-loop; other site 134676018290 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 134676018291 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 134676018292 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 134676018293 dimerization interface [polypeptide binding]; other site 134676018294 putative Zn2+ binding site [ion binding]; other site 134676018295 putative DNA binding site [nucleotide binding]; other site 134676018296 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 134676018297 putative DNA binding site [nucleotide binding]; other site 134676018298 Predicted transcriptional regulators [Transcription]; Region: COG1695 134676018299 putative Zn2+ binding site [ion binding]; other site 134676018300 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 134676018301 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 134676018302 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 134676018303 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 134676018304 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 134676018305 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 134676018306 RIP metalloprotease RseP; Region: TIGR00054 134676018307 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 134676018308 active site 134676018309 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 134676018310 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 134676018311 putative substrate binding region [chemical binding]; other site 134676018312 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 134676018313 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 134676018314 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 134676018315 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 134676018316 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 134676018317 putative active site [active] 134676018318 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 134676018319 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 134676018320 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 134676018321 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 134676018322 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 134676018323 iron-sulfur cluster [ion binding]; other site 134676018324 [2Fe-2S] cluster binding site [ion binding]; other site 134676018325 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 134676018326 DivIVA domain; Region: DivI1A_domain; TIGR03544 134676018327 DivIVA domain; Region: DivI1A_domain; TIGR03544 134676018328 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 134676018329 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 134676018330 FeS/SAM binding site; other site 134676018331 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 134676018332 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 134676018333 ribosome recycling factor; Reviewed; Region: frr; PRK00083 134676018334 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 134676018335 hinge region; other site 134676018336 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 134676018337 putative nucleotide binding site [chemical binding]; other site 134676018338 uridine monophosphate binding site [chemical binding]; other site 134676018339 homohexameric interface [polypeptide binding]; other site 134676018340 elongation factor Ts; Provisional; Region: tsf; PRK09377 134676018341 UBA/TS-N domain; Region: UBA; pfam00627 134676018342 Elongation factor TS; Region: EF_TS; pfam00889 134676018343 Elongation factor TS; Region: EF_TS; pfam00889 134676018344 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 134676018345 rRNA interaction site [nucleotide binding]; other site 134676018346 S8 interaction site; other site 134676018347 putative laminin-1 binding site; other site 134676018348 hypothetical protein; Reviewed; Region: PRK12497 134676018349 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 134676018350 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 134676018351 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 134676018352 Walker A motif; other site 134676018353 ATP binding site [chemical binding]; other site 134676018354 Walker B motif; other site 134676018355 arginine finger; other site 134676018356 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 134676018357 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 134676018358 DNA protecting protein DprA; Region: dprA; TIGR00732 134676018359 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 134676018360 putative DNA binding site [nucleotide binding]; other site 134676018361 putative Zn2+ binding site [ion binding]; other site 134676018362 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 134676018363 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 134676018364 DNA-binding site [nucleotide binding]; DNA binding site 134676018365 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 134676018366 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 134676018367 active site 134676018368 DNA binding site [nucleotide binding] 134676018369 Int/Topo IB signature motif; other site 134676018370 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 134676018371 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 134676018372 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 134676018373 catalytic residue [active] 134676018374 Peptidase family M23; Region: Peptidase_M23; pfam01551 134676018375 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 134676018376 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 134676018377 RNA/DNA hybrid binding site [nucleotide binding]; other site 134676018378 active site 134676018379 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 134676018380 nudix motif; other site 134676018381 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 134676018382 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 134676018383 Catalytic site [active] 134676018384 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 134676018385 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 134676018386 Catalytic site [active] 134676018387 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 134676018388 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 134676018389 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 134676018390 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 134676018391 RimM N-terminal domain; Region: RimM; pfam01782 134676018392 PRC-barrel domain; Region: PRC; pfam05239 134676018393 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 134676018394 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 134676018395 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 134676018396 Protein of unknown function (DUF402); Region: DUF402; pfam04167 134676018397 prolyl-tRNA synthetase; Provisional; Region: PRK08661 134676018398 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 134676018399 dimer interface [polypeptide binding]; other site 134676018400 motif 1; other site 134676018401 active site 134676018402 motif 2; other site 134676018403 motif 3; other site 134676018404 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 134676018405 anticodon binding site; other site 134676018406 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 134676018407 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 134676018408 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 134676018409 DNA binding residues [nucleotide binding] 134676018410 PQQ-like domain; Region: PQQ_2; pfam13360 134676018411 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 134676018412 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 134676018413 active site 134676018414 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 134676018415 putative active site [active] 134676018416 signal recognition particle protein; Provisional; Region: PRK10867 134676018417 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 134676018418 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 134676018419 P loop; other site 134676018420 GTP binding site [chemical binding]; other site 134676018421 Signal peptide binding domain; Region: SRP_SPB; pfam02978 134676018422 Protein of unknown function (DUF3184); Region: DUF3184; pfam11380 134676018423 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 134676018424 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 134676018425 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 134676018426 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 134676018427 Predicted membrane protein [Function unknown]; Region: COG2246 134676018428 GtrA-like protein; Region: GtrA; pfam04138 134676018429 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 134676018430 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 134676018431 Ligand binding site; other site 134676018432 Putative Catalytic site; other site 134676018433 DXD motif; other site 134676018434 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 134676018435 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 134676018436 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 134676018437 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 134676018438 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 134676018439 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 134676018440 active site 134676018441 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 134676018442 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 134676018443 Methyltransferase domain; Region: Methyltransf_24; pfam13578 134676018444 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 134676018445 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 134676018446 active site 134676018447 PII uridylyl-transferase; Provisional; Region: PRK03381 134676018448 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 134676018449 metal binding triad; other site 134676018450 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 134676018451 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 134676018452 Zn2+ binding site [ion binding]; other site 134676018453 Mg2+ binding site [ion binding]; other site 134676018454 ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD; Region: ACT_UUR-ACR-like; cd04873 134676018455 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 134676018456 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 134676018457 Nitrogen regulatory protein P-II; Region: P-II; smart00938 134676018458 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 134676018459 Phosphotransferase enzyme family; Region: APH; pfam01636 134676018460 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 134676018461 active site 134676018462 ATP binding site [chemical binding]; other site 134676018463 substrate binding site [chemical binding]; other site 134676018464 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 134676018465 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 134676018466 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 134676018467 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 134676018468 putative active site [active] 134676018469 putative metal binding site [ion binding]; other site 134676018470 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 134676018471 Protein of unknown function (DUF664); Region: DUF664; pfam04978 134676018472 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 134676018473 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 134676018474 motif II; other site 134676018475 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 134676018476 AAA domain; Region: AAA_23; pfam13476 134676018477 Walker A/P-loop; other site 134676018478 ATP binding site [chemical binding]; other site 134676018479 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 134676018480 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 134676018481 ABC transporter signature motif; other site 134676018482 Walker B; other site 134676018483 D-loop; other site 134676018484 H-loop/switch region; other site 134676018485 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 134676018486 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 134676018487 Spherulation-specific family 4; Region: Spherulin4; pfam12138 134676018488 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 134676018489 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 134676018490 DNA binding site [nucleotide binding] 134676018491 catalytic residue [active] 134676018492 H2TH interface [polypeptide binding]; other site 134676018493 putative catalytic residues [active] 134676018494 turnover-facilitating residue; other site 134676018495 intercalation triad [nucleotide binding]; other site 134676018496 8OG recognition residue [nucleotide binding]; other site 134676018497 putative reading head residues; other site 134676018498 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 134676018499 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 134676018500 ribonuclease III; Reviewed; Region: rnc; PRK00102 134676018501 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 134676018502 dimerization interface [polypeptide binding]; other site 134676018503 active site 134676018504 metal binding site [ion binding]; metal-binding site 134676018505 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 134676018506 dsRNA binding site [nucleotide binding]; other site 134676018507 Fatty acid synthesis protein; Region: FA_synthesis; cl17261 134676018508 Fatty acid synthesis protein; Region: FA_synthesis; cl17261 134676018509 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 134676018510 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 134676018511 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 134676018512 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 134676018513 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 134676018514 active site 134676018515 (T/H)XGH motif; other site 134676018516 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 134676018517 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 134676018518 S-adenosylmethionine binding site [chemical binding]; other site 134676018519 Protein of unknown function (DUF952); Region: DUF952; cl01393 134676018520 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 134676018521 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 134676018522 generic binding surface II; other site 134676018523 ssDNA binding site; other site 134676018524 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 134676018525 ATP binding site [chemical binding]; other site 134676018526 putative Mg++ binding site [ion binding]; other site 134676018527 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 134676018528 nucleotide binding region [chemical binding]; other site 134676018529 ATP-binding site [chemical binding]; other site 134676018530 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 134676018531 DAK2 domain; Region: Dak2; pfam02734 134676018532 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 134676018533 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 134676018534 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 134676018535 thiamine monophosphate kinase; Provisional; Region: PRK05731 134676018536 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 134676018537 ATP binding site [chemical binding]; other site 134676018538 dimerization interface [polypeptide binding]; other site 134676018539 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 134676018540 AsnC family; Region: AsnC_trans_reg; pfam01037 134676018541 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 134676018542 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 134676018543 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 134676018544 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 134676018545 cystathionine gamma-lyase; Validated; Region: PRK07582 134676018546 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 134676018547 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 134676018548 catalytic residue [active] 134676018549 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 134676018550 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 134676018551 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 134676018552 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 134676018553 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 134676018554 putative acyl-acceptor binding pocket; other site 134676018555 2-phospho-L-lactate guanylyltransferase; Region: F420_cofC; TIGR03552 134676018556 polyphosphate kinase; Provisional; Region: PRK05443 134676018557 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 134676018558 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 134676018559 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 134676018560 putative domain interface [polypeptide binding]; other site 134676018561 putative active site [active] 134676018562 catalytic site [active] 134676018563 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 134676018564 putative domain interface [polypeptide binding]; other site 134676018565 putative active site [active] 134676018566 catalytic site [active] 134676018567 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 134676018568 active site 134676018569 Ap6A binding site [chemical binding]; other site 134676018570 nudix motif; other site 134676018571 metal binding site [ion binding]; metal-binding site 134676018572 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 134676018573 catalytic core [active] 134676018574 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 134676018575 IHF dimer interface [polypeptide binding]; other site 134676018576 IHF - DNA interface [nucleotide binding]; other site 134676018577 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 134676018578 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 134676018579 substrate binding site [chemical binding]; other site 134676018580 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 134676018581 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 134676018582 substrate binding site [chemical binding]; other site 134676018583 ligand binding site [chemical binding]; other site 134676018584 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 134676018585 Transcriptional regulator [Transcription]; Region: IclR; COG1414 134676018586 Bacterial transcriptional regulator; Region: IclR; pfam01614 134676018587 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 134676018588 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 134676018589 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 134676018590 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 134676018591 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 134676018592 non-specific DNA binding site [nucleotide binding]; other site 134676018593 salt bridge; other site 134676018594 sequence-specific DNA binding site [nucleotide binding]; other site 134676018595 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 134676018596 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 134676018597 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 134676018598 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 134676018599 Walker A/P-loop; other site 134676018600 ATP binding site [chemical binding]; other site 134676018601 Q-loop/lid; other site 134676018602 ABC transporter signature motif; other site 134676018603 Walker B; other site 134676018604 D-loop; other site 134676018605 H-loop/switch region; other site 134676018606 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 134676018607 Protein tyrosine phosphatase, catalytic domain motif; Region: PTPc_motif; smart00404 134676018608 active site 134676018609 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 134676018610 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 134676018611 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 134676018612 active site 134676018613 catalytic residues [active] 134676018614 metal binding site [ion binding]; metal-binding site 134676018615 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 134676018616 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 134676018617 active site 134676018618 dimer interface [polypeptide binding]; other site 134676018619 motif 1; other site 134676018620 motif 2; other site 134676018621 motif 3; other site 134676018622 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 134676018623 anticodon binding site; other site 134676018624 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 134676018625 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 134676018626 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 134676018627 putative catalytic site [active] 134676018628 putative metal binding site [ion binding]; other site 134676018629 putative phosphate binding site [ion binding]; other site 134676018630 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 134676018631 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 134676018632 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 134676018633 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 134676018634 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 134676018635 hypothetical protein; Provisional; Region: PRK09256 134676018636 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 134676018637 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 134676018638 homodimer interface [polypeptide binding]; other site 134676018639 substrate-cofactor binding pocket; other site 134676018640 catalytic residue [active] 134676018641 tartrate dehydrogenase; Region: TTC; TIGR02089 134676018642 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 134676018643 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 134676018644 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 134676018645 ligand binding site [chemical binding]; other site 134676018646 NAD binding site [chemical binding]; other site 134676018647 dimerization interface [polypeptide binding]; other site 134676018648 catalytic site [active] 134676018649 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 134676018650 putative L-serine binding site [chemical binding]; other site 134676018651 ketol-acid reductoisomerase; Provisional; Region: PRK05479 134676018652 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 134676018653 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 134676018654 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 134676018655 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 134676018656 putative valine binding site [chemical binding]; other site 134676018657 dimer interface [polypeptide binding]; other site 134676018658 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 134676018659 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 134676018660 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 134676018661 PYR/PP interface [polypeptide binding]; other site 134676018662 dimer interface [polypeptide binding]; other site 134676018663 TPP binding site [chemical binding]; other site 134676018664 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cd00368 134676018665 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 134676018666 TPP-binding site [chemical binding]; other site 134676018667 dimer interface [polypeptide binding]; other site 134676018668 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 134676018669 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676018670 metal binding site [ion binding]; metal-binding site 134676018671 active site 134676018672 I-site; other site 134676018673 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 134676018674 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 134676018675 Uncharacterized bacterial family of heme peroxidases; Region: An_peroxidase_bacterial_2; cd09821 134676018676 putative heme binding site [chemical binding]; other site 134676018677 putative substrate binding site [chemical binding]; other site 134676018678 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 134676018679 Interdomain contacts; other site 134676018680 Cytokine receptor motif; other site 134676018681 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 134676018682 Interdomain contacts; other site 134676018683 Cytokine receptor motif; other site 134676018684 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 134676018685 Interdomain contacts; other site 134676018686 Cytokine receptor motif; other site 134676018687 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 134676018688 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 134676018689 Multicopper oxidase; Region: Cu-oxidase; pfam00394 134676018690 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 134676018691 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 134676018692 DNA binding site [nucleotide binding] 134676018693 Bacterial transcriptional activator domain; Region: BTAD; smart01043 134676018694 AAA ATPase domain; Region: AAA_16; pfam13191 134676018695 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 134676018696 putative substrate translocation pore; other site 134676018697 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 134676018698 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 134676018699 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 134676018700 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 134676018701 Transcriptional regulators [Transcription]; Region: PurR; COG1609 134676018702 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 134676018703 DNA binding site [nucleotide binding] 134676018704 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 134676018705 ligand binding site [chemical binding]; other site 134676018706 dimerization interface [polypeptide binding]; other site 134676018707 PAS domain S-box; Region: sensory_box; TIGR00229 134676018708 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 134676018709 putative active site [active] 134676018710 heme pocket [chemical binding]; other site 134676018711 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676018712 metal binding site [ion binding]; metal-binding site 134676018713 active site 134676018714 I-site; other site 134676018715 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 134676018716 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 134676018717 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 134676018718 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 134676018719 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 134676018720 putative active site [active] 134676018721 putative metal binding site [ion binding]; other site 134676018722 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 134676018723 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 134676018724 GatB domain; Region: GatB_Yqey; smart00845 134676018725 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 134676018726 Zn binding site [ion binding]; other site 134676018727 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 134676018728 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 134676018729 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 134676018730 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 134676018731 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676018732 metal binding site [ion binding]; metal-binding site 134676018733 active site 134676018734 I-site; other site 134676018735 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 134676018736 Ligase N family; Region: LIGANc; smart00532 134676018737 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 134676018738 nucleotide binding pocket [chemical binding]; other site 134676018739 K-X-D-G motif; other site 134676018740 catalytic site [active] 134676018741 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 134676018742 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 134676018743 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 134676018744 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 134676018745 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 134676018746 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 134676018747 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 134676018748 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 134676018749 catalytic residue [active] 134676018750 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 134676018751 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 134676018752 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 134676018753 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 134676018754 Ligand binding site [chemical binding]; other site 134676018755 Electron transfer flavoprotein domain; Region: ETF; pfam01012 134676018756 Domain of unknown function (DUF202); Region: DUF202; cl09954 134676018757 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 134676018758 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 134676018759 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 134676018760 DNA binding residues [nucleotide binding] 134676018761 hypothetical protein; Provisional; Region: PRK05858 134676018762 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 134676018763 PYR/PP interface [polypeptide binding]; other site 134676018764 dimer interface [polypeptide binding]; other site 134676018765 TPP binding site [chemical binding]; other site 134676018766 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 134676018767 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 134676018768 TPP-binding site; other site 134676018769 dimer interface [polypeptide binding]; other site 134676018770 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 134676018771 nucleotide binding site [chemical binding]; other site 134676018772 putative NEF/HSP70 interaction site [polypeptide binding]; other site 134676018773 SBD interface [polypeptide binding]; other site 134676018774 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 134676018775 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 134676018776 substrate binding site [chemical binding]; other site 134676018777 oxyanion hole (OAH) forming residues; other site 134676018778 trimer interface [polypeptide binding]; other site 134676018779 Predicted membrane protein [Function unknown]; Region: COG4270 134676018780 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 134676018781 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 134676018782 substrate binding site [chemical binding]; other site 134676018783 ATP binding site [chemical binding]; other site 134676018784 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 134676018785 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 134676018786 Walker A/P-loop; other site 134676018787 ATP binding site [chemical binding]; other site 134676018788 Q-loop/lid; other site 134676018789 ABC transporter signature motif; other site 134676018790 Walker B; other site 134676018791 D-loop; other site 134676018792 H-loop/switch region; other site 134676018793 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 134676018794 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 134676018795 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 134676018796 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 134676018797 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 134676018798 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839 134676018799 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 134676018800 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 134676018801 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 134676018802 Arginase-like amidino hydrolase family; Region: Arginase-like_1; cd09999 134676018803 active site 134676018804 Mn binding site [ion binding]; other site 134676018805 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 134676018806 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 134676018807 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 134676018808 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 134676018809 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 134676018810 Predicted transcriptional regulators [Transcription]; Region: COG1695 134676018811 Transcriptional regulator PadR-like family; Region: PadR; cl17335 134676018812 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 134676018813 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 134676018814 Walker A; other site 134676018815 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 134676018816 Switch II region; other site 134676018817 G4 box; other site 134676018818 G5 box; other site 134676018819 putative acyltransferase; Provisional; Region: PRK05790 134676018820 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 134676018821 dimer interface [polypeptide binding]; other site 134676018822 active site 134676018823 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 134676018824 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 134676018825 dimer interface [polypeptide binding]; other site 134676018826 substrate binding site [chemical binding]; other site 134676018827 metal binding site [ion binding]; metal-binding site 134676018828 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 134676018829 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 134676018830 ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133 134676018831 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 134676018832 Walker A/P-loop; other site 134676018833 ATP binding site [chemical binding]; other site 134676018834 Q-loop/lid; other site 134676018835 ABC transporter signature motif; other site 134676018836 Walker B; other site 134676018837 D-loop; other site 134676018838 H-loop/switch region; other site 134676018839 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 134676018840 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 134676018841 NAD(P) binding site [chemical binding]; other site 134676018842 catalytic residues [active] 134676018843 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 134676018844 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 134676018845 hypothetical protein; Provisional; Region: PRK03298 134676018846 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 134676018847 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 134676018848 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 134676018849 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 134676018850 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 134676018851 Protein of unknown function (DUF3500); Region: DUF3500; pfam12006 134676018852 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 134676018853 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 134676018854 hinge; other site 134676018855 active site 134676018856 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 134676018857 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 134676018858 putative dimer interface [polypeptide binding]; other site 134676018859 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 134676018860 ligand binding site [chemical binding]; other site 134676018861 Zn binding site [ion binding]; other site 134676018862 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 134676018863 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 134676018864 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 134676018865 LBP interface [polypeptide binding]; other site 134676018866 epsilon subunit interface [polypeptide binding]; other site 134676018867 gamma subunit interface [polypeptide binding]; other site 134676018868 Transcriptional regulator [Transcription]; Region: LytR; COG1316 134676018869 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 134676018870 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 134676018871 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 134676018872 alpha subunit interaction interface [polypeptide binding]; other site 134676018873 Walker A motif; other site 134676018874 ATP binding site [chemical binding]; other site 134676018875 Walker B motif; other site 134676018876 inhibitor binding site; inhibition site 134676018877 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 134676018878 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 134676018879 core domain interface [polypeptide binding]; other site 134676018880 delta subunit interface [polypeptide binding]; other site 134676018881 epsilon subunit interface [polypeptide binding]; other site 134676018882 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 134676018883 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 134676018884 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 134676018885 beta subunit interaction interface [polypeptide binding]; other site 134676018886 Walker A motif; other site 134676018887 ATP binding site [chemical binding]; other site 134676018888 Walker B motif; other site 134676018889 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 134676018890 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 134676018891 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 134676018892 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 134676018893 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 134676018894 ATP synthase subunit C; Region: ATP-synt_C; cl00466 134676018895 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 134676018896 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 134676018897 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754 134676018898 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 134676018899 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 134676018900 dimer interface [polypeptide binding]; other site 134676018901 active site 134676018902 glycine-pyridoxal phosphate binding site [chemical binding]; other site 134676018903 folate binding site [chemical binding]; other site 134676018904 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 134676018905 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 134676018906 NAD(P) binding site [chemical binding]; other site 134676018907 active site 134676018908 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 134676018909 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 134676018910 homotrimer interaction site [polypeptide binding]; other site 134676018911 putative active site [active] 134676018912 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 134676018913 putative catalytic site [active] 134676018914 putative metal binding site [ion binding]; other site 134676018915 putative phosphate binding site [ion binding]; other site 134676018916 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 134676018917 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 134676018918 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 134676018919 Low molecular weight phosphatase family; Region: LMWPc; cd00115 134676018920 active site 134676018921 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 134676018922 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 134676018923 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 134676018924 S-adenosylmethionine binding site [chemical binding]; other site 134676018925 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 134676018926 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676018927 metal binding site [ion binding]; metal-binding site 134676018928 active site 134676018929 I-site; other site 134676018930 PQQ-like domain; Region: PQQ_2; pfam13360 134676018931 This domain is found in peptide chain release factors; Region: PCRF; smart00937 134676018932 peptide chain release factor 1; Validated; Region: prfA; PRK00591 134676018933 RF-1 domain; Region: RF-1; pfam00472 134676018934 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 134676018935 RNA ligase; Region: RNA_lig_T4_1; cl09743 134676018936 polynucleotide kinase; Provisional; Region: pseT; PHA02530 134676018937 hypothetical protein; Provisional; Region: PRK06762 134676018938 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 134676018939 RNA ligase; Region: RNA_ligase; pfam09414 134676018940 Nitric oxide synthase (NOS) produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N(omega)-hydroxy-L-arginine (NHA) as an...; Region: NOS_oxygenase; cd00575 134676018941 active site 134676018942 dimer interface [polypeptide binding]; other site 134676018943 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 134676018944 transcription termination factor Rho; Provisional; Region: PRK12608 134676018945 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 134676018946 RNA binding site [nucleotide binding]; other site 134676018947 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 134676018948 Walker A motif; other site 134676018949 ATP binding site [chemical binding]; other site 134676018950 Walker B motif; other site 134676018951 homoserine kinase; Provisional; Region: PRK01212 134676018952 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 134676018953 H+ Antiporter protein; Region: 2A0121; TIGR00900 134676018954 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 134676018955 Protein export membrane protein; Region: SecD_SecF; cl14618 134676018956 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 134676018957 MarR family; Region: MarR; pfam01047 134676018958 threonine synthase; Reviewed; Region: PRK06721 134676018959 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 134676018960 homodimer interface [polypeptide binding]; other site 134676018961 pyridoxal 5'-phosphate binding site [chemical binding]; other site 134676018962 catalytic residue [active] 134676018963 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 134676018964 active site 134676018965 metal binding site [ion binding]; metal-binding site 134676018966 homoserine dehydrogenase; Provisional; Region: PRK06349 134676018967 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 134676018968 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 134676018969 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 134676018970 diaminopimelate decarboxylase; Region: lysA; TIGR01048 134676018971 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 134676018972 active site 134676018973 substrate binding site [chemical binding]; other site 134676018974 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 134676018975 catalytic residues [active] 134676018976 dimer interface [polypeptide binding]; other site 134676018977 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 134676018978 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 134676018979 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 134676018980 active site 134676018981 HIGH motif; other site 134676018982 KMSK motif region; other site 134676018983 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 134676018984 tRNA binding surface [nucleotide binding]; other site 134676018985 anticodon binding site; other site 134676018986 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 134676018987 Domain of unknown function (DUF305); Region: DUF305; pfam03713 134676018988 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 134676018989 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 134676018990 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 134676018991 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 134676018992 Zn binding site [ion binding]; other site 134676018993 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 134676018994 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 134676018995 putative substrate translocation pore; other site 134676018996 Major Facilitator Superfamily; Region: MFS_1; pfam07690 134676018997 The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506 134676018998 peptide binding site [polypeptide binding]; other site 134676018999 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 134676019000 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 134676019001 PYR/PP interface [polypeptide binding]; other site 134676019002 dimer interface [polypeptide binding]; other site 134676019003 TPP binding site [chemical binding]; other site 134676019004 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 134676019005 TPP-binding site [chemical binding]; other site 134676019006 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 134676019007 M20 Peptidase acetylornithine deacetylase/acetyl-lysine deacetylase; Region: M20_ArgE_LysK; cd05653 134676019008 acetyl-lysine deacetylase; Provisional; Region: PRK04443 134676019009 metal binding site [ion binding]; metal-binding site 134676019010 putative dimer interface [polypeptide binding]; other site 134676019011 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 134676019012 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 134676019013 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 134676019014 inhibitor-cofactor binding pocket; inhibition site 134676019015 pyridoxal 5'-phosphate binding site [chemical binding]; other site 134676019016 catalytic residue [active] 134676019017 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 134676019018 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 134676019019 Lysine biosynthesis enzyme LysX; Region: LysX_arch; TIGR02144 134676019020 ATP-grasp domain; Region: ATP-grasp_4; cl17255 134676019021 lysine biosynthesis protein LysW; Region: lysW; TIGR01206 134676019022 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 134676019023 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 134676019024 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 134676019025 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 134676019026 Catalytic site [active] 134676019027 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 134676019028 active site 134676019029 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 134676019030 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 134676019031 tetramer interface [polypeptide binding]; other site 134676019032 active site 134676019033 Mg2+/Mn2+ binding site [ion binding]; other site 134676019034 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 134676019035 putative DNA binding site [nucleotide binding]; other site 134676019036 putative Zn2+ binding site [ion binding]; other site 134676019037 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 134676019038 Catalytic domain of Protein Kinases; Region: PKc; cd00180 134676019039 active site 134676019040 ATP binding site [chemical binding]; other site 134676019041 substrate binding site [chemical binding]; other site 134676019042 activation loop (A-loop); other site 134676019043 Predicted acyl esterases [General function prediction only]; Region: COG2936 134676019044 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 134676019045 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 134676019046 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 134676019047 Predicted transcriptional regulators [Transcription]; Region: COG1733 134676019048 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 134676019049 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 134676019050 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 134676019051 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 134676019052 anti sigma factor interaction site; other site 134676019053 regulatory phosphorylation site [posttranslational modification]; other site 134676019054 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 134676019055 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 134676019056 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 134676019057 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 134676019058 Uncharacterized protein conserved in archaea [Function unknown]; Region: COG4034 134676019059 Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503 134676019060 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 134676019061 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 134676019062 NAD(P) binding site [chemical binding]; other site 134676019063 active site 134676019064 trehalose synthase; Region: treS_nterm; TIGR02456 134676019065 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 134676019066 active site 134676019067 catalytic site [active] 134676019068 Predicted transcriptional regulators [Transcription]; Region: COG1695 134676019069 Transcriptional regulator PadR-like family; Region: PadR; cl17335 134676019070 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 134676019071 aromatic chitin/cellulose binding site residues [chemical binding]; other site 134676019072 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 134676019073 active site 134676019074 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 134676019075 aromatic chitin/cellulose binding site residues [chemical binding]; other site 134676019076 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 134676019077 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 134676019078 putative active site [active] 134676019079 Streptomyces laminarinase-like, member of glycosyl hydrolase family 16; Region: GH16_Strep_laminarinase_like; cd02182 134676019080 active site 134676019081 catalytic residues [active] 134676019082 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 134676019083 metal binding site [ion binding]; metal-binding site 134676019084 ligand binding site [chemical binding]; other site 134676019085 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 134676019086 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 134676019087 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 134676019088 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 134676019089 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 134676019090 NodB motif; other site 134676019091 active site 134676019092 catalytic site [active] 134676019093 metal binding site [ion binding]; metal-binding site 134676019094 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 134676019095 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 134676019096 putative DNA binding site [nucleotide binding]; other site 134676019097 catalytic residue [active] 134676019098 putative H2TH interface [polypeptide binding]; other site 134676019099 putative catalytic residues [active] 134676019100 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 134676019101 Clp protease; Region: CLP_protease; pfam00574 134676019102 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 134676019103 oligomer interface [polypeptide binding]; other site 134676019104 active site residues [active] 134676019105 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 134676019106 Amidinotransferase; Region: Amidinotransf; cl12043 134676019107 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 134676019108 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 134676019109 inhibitor-cofactor binding pocket; inhibition site 134676019110 pyridoxal 5'-phosphate binding site [chemical binding]; other site 134676019111 catalytic residue [active] 134676019112 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 134676019113 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 134676019114 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 134676019115 putative acyl-acceptor binding pocket; other site 134676019116 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 134676019117 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 134676019118 nucleophile elbow; other site 134676019119 Uncharacterized protein conserved in archaea (DUF2180); Region: DUF2180; cl02017 134676019120 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 134676019121 ligand binding site [chemical binding]; other site 134676019122 flexible hinge region; other site 134676019123 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 134676019124 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 134676019125 protein binding site [polypeptide binding]; other site 134676019126 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 134676019127 dimerization interface [polypeptide binding]; other site 134676019128 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 134676019129 dimer interface [polypeptide binding]; other site 134676019130 phosphorylation site [posttranslational modification] 134676019131 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676019132 ATP binding site [chemical binding]; other site 134676019133 Mg2+ binding site [ion binding]; other site 134676019134 G-X-G motif; other site 134676019135 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 134676019136 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676019137 active site 134676019138 phosphorylation site [posttranslational modification] 134676019139 intermolecular recognition site; other site 134676019140 dimerization interface [polypeptide binding]; other site 134676019141 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 134676019142 DNA binding site [nucleotide binding] 134676019143 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 134676019144 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 134676019145 putative acyl-acceptor binding pocket; other site 134676019146 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 134676019147 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 134676019148 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 134676019149 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 134676019150 TPP-binding site [chemical binding]; other site 134676019151 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 134676019152 phosphate acetyltransferase; Reviewed; Region: PRK05632 134676019153 DRTGG domain; Region: DRTGG; pfam07085 134676019154 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 134676019155 Acetokinase family; Region: Acetate_kinase; cl17229 134676019156 propionate/acetate kinase; Provisional; Region: PRK12379 134676019157 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 134676019158 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 134676019159 NAD(P) binding site [chemical binding]; other site 134676019160 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 134676019161 Malic enzyme, N-terminal domain; Region: malic; pfam00390 134676019162 Malic enzyme, NAD binding domain; Region: Malic_M; smart00919 134676019163 NAD(P) binding pocket [chemical binding]; other site 134676019164 Predicted transcriptional regulator [Transcription]; Region: COG2932 134676019165 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 134676019166 Catalytic site [active] 134676019167 Nickel-containing superoxide dismutase; Region: Sod_Ni; pfam09055 134676019168 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 134676019169 Transcriptional regulators [Transcription]; Region: FadR; COG2186 134676019170 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 134676019171 DNA-binding site [nucleotide binding]; DNA binding site 134676019172 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 134676019173 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 134676019174 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 134676019175 Transcription factor WhiB; Region: Whib; pfam02467 134676019176 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 134676019177 putative active site [active] 134676019178 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 134676019179 putative active site [active] 134676019180 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 134676019181 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 134676019182 Active Sites [active] 134676019183 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 134676019184 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 134676019185 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 134676019186 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 134676019187 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 134676019188 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 134676019189 Histidine kinase; Region: HisKA_2; pfam07568 134676019190 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676019191 ATP binding site [chemical binding]; other site 134676019192 Mg2+ binding site [ion binding]; other site 134676019193 G-X-G motif; other site 134676019194 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 134676019195 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 134676019196 dimer interface [polypeptide binding]; other site 134676019197 active site 134676019198 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 134676019199 dimer interface [polypeptide binding]; other site 134676019200 active site 134676019201 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 134676019202 Tetratricopeptide repeat; Region: TPR_16; pfam13432 134676019203 TPR motif; other site 134676019204 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 134676019205 carboxyltransferase (CT) interaction site; other site 134676019206 biotinylation site [posttranslational modification]; other site 134676019207 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988 134676019208 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 134676019209 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 134676019210 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 134676019211 DNA binding residues [nucleotide binding] 134676019212 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 134676019213 Transcription factor WhiB; Region: Whib; pfam02467 134676019214 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 134676019215 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 134676019216 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 134676019217 hinge; other site 134676019218 active site 134676019219 Predicted GTPases [General function prediction only]; Region: COG1162 134676019220 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 134676019221 GTPase/Zn-binding domain interface [polypeptide binding]; other site 134676019222 GTP/Mg2+ binding site [chemical binding]; other site 134676019223 G4 box; other site 134676019224 G1 box; other site 134676019225 Switch I region; other site 134676019226 G2 box; other site 134676019227 G3 box; other site 134676019228 Switch II region; other site 134676019229 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 134676019230 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 134676019231 active site 134676019232 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 134676019233 Uncharacterized conserved protein [Function unknown]; Region: COG5439 134676019234 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 134676019235 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 134676019236 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 134676019237 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 134676019238 active site 134676019239 catalytic residues [active] 134676019240 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 134676019241 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 134676019242 putative sugar binding sites [chemical binding]; other site 134676019243 Q-X-W motif; other site 134676019244 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 134676019245 sugar binding site [chemical binding]; other site 134676019246 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 134676019247 catalytic residue [active] 134676019248 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 134676019249 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 134676019250 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 134676019251 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 134676019252 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 134676019253 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 134676019254 S-adenosylmethionine binding site [chemical binding]; other site 134676019255 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 134676019256 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 134676019257 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 134676019258 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 134676019259 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 134676019260 Lipase (class 2); Region: Lipase_2; pfam01674 134676019261 Transcriptional regulator [Transcription]; Region: LytR; COG1316 134676019262 PQQ-like domain; Region: PQQ_2; pfam13360 134676019263 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 134676019264 structural tetrad; other site 134676019265 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 134676019266 Major Facilitator Superfamily; Region: MFS_1; pfam07690 134676019267 putative substrate translocation pore; other site 134676019268 MarR family; Region: MarR_2; pfam12802 134676019269 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 134676019270 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 134676019271 putative substrate translocation pore; other site 134676019272 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 134676019273 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 134676019274 non-specific DNA binding site [nucleotide binding]; other site 134676019275 salt bridge; other site 134676019276 sequence-specific DNA binding site [nucleotide binding]; other site 134676019277 Cupin domain; Region: Cupin_2; pfam07883 134676019278 Glyoxal oxidase N-terminus; Region: Glyoxal_oxid_N; pfam07250 134676019279 C-terminal Early set domain associated with the catalytic domain of galactose oxidase; Region: E_set_GO_C; cd02851 134676019280 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 134676019281 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 134676019282 putative sugar binding sites [chemical binding]; other site 134676019283 Q-X-W motif; other site 134676019284 hypothetical protein; Validated; Region: PRK00068 134676019285 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 134676019286 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 134676019287 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 134676019288 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 134676019289 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 134676019290 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 134676019291 Protein of unknown function DUF45; Region: DUF45; pfam01863 134676019292 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 134676019293 ABC1 family; Region: ABC1; pfam03109 134676019294 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 134676019295 active site 134676019296 ATP binding site [chemical binding]; other site 134676019297 Transcription factor WhiB; Region: Whib; pfam02467 134676019298 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 134676019299 Part of AAA domain; Region: AAA_19; pfam13245 134676019300 Family description; Region: UvrD_C_2; pfam13538 134676019301 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 134676019302 HRDC domain; Region: HRDC; pfam00570 134676019303 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 134676019304 catalytic residues [active] 134676019305 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 134676019306 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 134676019307 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 134676019308 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 134676019309 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 134676019310 putative NADH binding site [chemical binding]; other site 134676019311 putative active site [active] 134676019312 nudix motif; other site 134676019313 putative metal binding site [ion binding]; other site 134676019314 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 134676019315 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 134676019316 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 134676019317 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 134676019318 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 134676019319 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 134676019320 Predicted transcriptional regulator [Transcription]; Region: COG1959 134676019321 Transcriptional regulator; Region: Rrf2; pfam02082 134676019322 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 134676019323 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 134676019324 substrate binding pocket [chemical binding]; other site 134676019325 membrane-bound complex binding site; other site 134676019326 hinge residues; other site 134676019327 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 134676019328 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 134676019329 Walker A/P-loop; other site 134676019330 ATP binding site [chemical binding]; other site 134676019331 Q-loop/lid; other site 134676019332 ABC transporter signature motif; other site 134676019333 Walker B; other site 134676019334 D-loop; other site 134676019335 H-loop/switch region; other site 134676019336 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 134676019337 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 134676019338 dimer interface [polypeptide binding]; other site 134676019339 conserved gate region; other site 134676019340 putative PBP binding loops; other site 134676019341 ABC-ATPase subunit interface; other site 134676019342 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 134676019343 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 134676019344 putative acyl-acceptor binding pocket; other site 134676019345 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 134676019346 DNA-binding site [nucleotide binding]; DNA binding site 134676019347 RNA-binding motif; other site 134676019348 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 134676019349 Part of AAA domain; Region: AAA_19; pfam13245 134676019350 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 134676019351 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 134676019352 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 134676019353 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 134676019354 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 134676019355 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 134676019356 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 134676019357 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 134676019358 metal binding site [ion binding]; metal-binding site 134676019359 putative dimer interface [polypeptide binding]; other site 134676019360 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 134676019361 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 134676019362 putative trimer interface [polypeptide binding]; other site 134676019363 putative CoA binding site [chemical binding]; other site 134676019364 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 134676019365 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 134676019366 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 134676019367 dimerization interface [polypeptide binding]; other site 134676019368 LysE type translocator; Region: LysE; cl00565 134676019369 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 134676019370 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 134676019371 DNA binding residues [nucleotide binding] 134676019372 drug binding residues [chemical binding]; other site 134676019373 dimer interface [polypeptide binding]; other site 134676019374 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cl17512 134676019375 beta-clamp/clamp loader binding surface; other site 134676019376 beta-clamp/translesion DNA polymerase binding surface; other site 134676019377 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 134676019378 short chain dehydrogenase; Provisional; Region: PRK07109 134676019379 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 134676019380 putative NAD(P) binding site [chemical binding]; other site 134676019381 active site 134676019382 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 134676019383 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 134676019384 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 134676019385 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 134676019386 pyridoxal 5'-phosphate binding site [chemical binding]; other site 134676019387 homodimer interface [polypeptide binding]; other site 134676019388 catalytic residue [active] 134676019389 Ferredoxin [Energy production and conversion]; Region: COG1146 134676019390 4Fe-4S binding domain; Region: Fer4; pfam00037 134676019391 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 134676019392 N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445 134676019393 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 134676019394 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 134676019395 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 134676019396 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 134676019397 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 134676019398 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 134676019399 L-aspartate oxidase; Provisional; Region: PRK06175 134676019400 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 134676019401 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 134676019402 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 134676019403 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 134676019404 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 134676019405 Coenzyme A binding pocket [chemical binding]; other site 134676019406 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 134676019407 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 134676019408 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 134676019409 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 134676019410 Walker A/P-loop; other site 134676019411 ATP binding site [chemical binding]; other site 134676019412 Q-loop/lid; other site 134676019413 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 134676019414 ABC transporter signature motif; other site 134676019415 Walker B; other site 134676019416 D-loop; other site 134676019417 H-loop/switch region; other site 134676019418 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 134676019419 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 134676019420 Walker A/P-loop; other site 134676019421 ATP binding site [chemical binding]; other site 134676019422 Q-loop/lid; other site 134676019423 ABC transporter signature motif; other site 134676019424 Walker B; other site 134676019425 D-loop; other site 134676019426 H-loop/switch region; other site 134676019427 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 134676019428 TM-ABC transporter signature motif; other site 134676019429 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 134676019430 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 134676019431 TM-ABC transporter signature motif; other site 134676019432 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 134676019433 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 134676019434 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 134676019435 classical (c) SDRs; Region: SDR_c; cd05233 134676019436 NAD(P) binding site [chemical binding]; other site 134676019437 active site 134676019438 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 134676019439 classical (c) SDRs; Region: SDR_c; cd05233 134676019440 NAD(P) binding site [chemical binding]; other site 134676019441 active site 134676019442 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 134676019443 Phosphotransferase enzyme family; Region: APH; pfam01636 134676019444 putative active site [active] 134676019445 putative substrate binding site [chemical binding]; other site 134676019446 ATP binding site [chemical binding]; other site 134676019447 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 134676019448 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 134676019449 active site 134676019450 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 134676019451 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676019452 AAA ATPase domain; Region: AAA_16; pfam13191 134676019453 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 134676019454 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 134676019455 DNA binding residues [nucleotide binding] 134676019456 dimerization interface [polypeptide binding]; other site 134676019457 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 134676019458 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 134676019459 NAD binding site [chemical binding]; other site 134676019460 catalytic Zn binding site [ion binding]; other site 134676019461 substrate binding site [chemical binding]; other site 134676019462 structural Zn binding site [ion binding]; other site 134676019463 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 134676019464 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 134676019465 NAD binding site [chemical binding]; other site 134676019466 catalytic residues [active] 134676019467 tetracycline repressor protein TetR; Provisional; Region: PRK13756 134676019468 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676019469 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 134676019470 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 134676019471 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 134676019472 acyl-activating enzyme (AAE) consensus motif; other site 134676019473 putative AMP binding site [chemical binding]; other site 134676019474 putative active site [active] 134676019475 putative CoA binding site [chemical binding]; other site 134676019476 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 134676019477 active site 134676019478 8-oxo-dGMP binding site [chemical binding]; other site 134676019479 nudix motif; other site 134676019480 metal binding site [ion binding]; metal-binding site 134676019481 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cl00942 134676019482 Pleckstrin homology-like domain; Region: PH-like; cl17171 134676019483 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 134676019484 active site pocket [active] 134676019485 oxyanion hole [active] 134676019486 catalytic triad [active] 134676019487 active site nucleophile [active] 134676019488 G5 domain; Region: G5; pfam07501 134676019489 Transcriptional regulators [Transcription]; Region: MarR; COG1846 134676019490 MarR family; Region: MarR; pfam01047 134676019491 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 134676019492 Coenzyme A binding pocket [chemical binding]; other site 134676019493 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 134676019494 putative active site [active] 134676019495 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 134676019496 GTP-binding protein YchF; Reviewed; Region: PRK09601 134676019497 YchF GTPase; Region: YchF; cd01900 134676019498 G1 box; other site 134676019499 GTP/Mg2+ binding site [chemical binding]; other site 134676019500 Switch I region; other site 134676019501 G2 box; other site 134676019502 Switch II region; other site 134676019503 G3 box; other site 134676019504 G4 box; other site 134676019505 G5 box; other site 134676019506 Protein of unknown function (DUF933); Region: YchF-GTPase_C; pfam06071 134676019507 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 134676019508 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 134676019509 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 134676019510 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 134676019511 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 134676019512 AlkA N-terminal domain; Region: AlkA_N; pfam06029 134676019513 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 134676019514 HhH-GPD superfamily base excision DNA repair protein; Region: HhH-GPD; pfam00730 134676019515 helix-hairpin-helix signature motif; other site 134676019516 substrate binding pocket [chemical binding]; other site 134676019517 active site 134676019518 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 134676019519 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 134676019520 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 134676019521 active site 134676019522 DNA binding site [nucleotide binding] 134676019523 Protein of unknown function (DUF3633); Region: DUF3633; pfam12315 134676019524 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 134676019525 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 134676019526 active site 134676019527 HIGH motif; other site 134676019528 nucleotide binding site [chemical binding]; other site 134676019529 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 134676019530 active site 134676019531 KMSKS motif; other site 134676019532 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 134676019533 tRNA binding surface [nucleotide binding]; other site 134676019534 anticodon binding site; other site 134676019535 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 134676019536 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 134676019537 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 134676019538 RmuC family; Region: RmuC; pfam02646 134676019539 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 134676019540 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 134676019541 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 134676019542 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 134676019543 generic binding surface II; other site 134676019544 generic binding surface I; other site 134676019545 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 134676019546 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 134676019547 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 134676019548 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 134676019549 putative active site [active] 134676019550 Rhomboid family; Region: Rhomboid; cl11446 134676019551 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 134676019552 cleavage site 134676019553 active site 134676019554 substrate binding sites [chemical binding]; other site 134676019555 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 134676019556 N-acetyl-D-glucosamine binding site [chemical binding]; other site 134676019557 catalytic residue [active] 134676019558 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 134676019559 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 134676019560 putative active site [active] 134676019561 PhoH-like protein; Region: PhoH; pfam02562 134676019562 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 134676019563 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 134676019564 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 134676019565 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 134676019566 catalytic residue [active] 134676019567 putative FPP diphosphate binding site; other site 134676019568 putative FPP binding hydrophobic cleft; other site 134676019569 dimer interface [polypeptide binding]; other site 134676019570 putative IPP diphosphate binding site; other site 134676019571 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 134676019572 active site 134676019573 substrate-binding site [chemical binding]; other site 134676019574 metal-binding site [ion binding] 134676019575 GTP binding site [chemical binding]; other site 134676019576 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 134676019577 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 134676019578 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 134676019579 DNA binding residues [nucleotide binding] 134676019580 Putative zinc-finger; Region: zf-HC2; pfam13490 134676019581 Predicted membrane protein [Function unknown]; Region: COG2246 134676019582 GtrA-like protein; Region: GtrA; pfam04138 134676019583 Predicted membrane protein [Function unknown]; Region: COG2246 134676019584 GtrA-like protein; Region: GtrA; pfam04138 134676019585 Bacterial PH domain; Region: DUF304; pfam03703 134676019586 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 134676019587 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 134676019588 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 134676019589 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 134676019590 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 134676019591 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 134676019592 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 134676019593 Catalytic domain of Protein Kinases; Region: PKc; cd00180 134676019594 active site 134676019595 ATP binding site [chemical binding]; other site 134676019596 substrate binding site [chemical binding]; other site 134676019597 activation loop (A-loop); other site 134676019598 polyketide-type polyunsaturated fatty acid synthase PfaA; Region: omega_3_PfaA; TIGR02813 134676019599 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 134676019600 active site 134676019601 catalytic residues [active] 134676019602 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 134676019603 active site 134676019604 dimer interface [polypeptide binding]; other site 134676019605 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 134676019606 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 134676019607 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 134676019608 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 134676019609 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 134676019610 carboxyltransferase (CT) interaction site; other site 134676019611 biotinylation site [posttranslational modification]; other site 134676019612 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 134676019613 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676019614 WHG domain; Region: WHG; pfam13305 134676019615 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 134676019616 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 134676019617 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 134676019618 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 134676019619 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 134676019620 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 134676019621 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 134676019622 dimerization interface [polypeptide binding]; other site 134676019623 putative catalytic residue [active] 134676019624 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 134676019625 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 134676019626 Coenzyme A binding pocket [chemical binding]; other site 134676019627 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 134676019628 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 134676019629 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 134676019630 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 134676019631 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 134676019632 metal binding site [ion binding]; metal-binding site 134676019633 putative dimer interface [polypeptide binding]; other site 134676019634 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 134676019635 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 134676019636 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 134676019637 active site 134676019638 ATP binding site [chemical binding]; other site 134676019639 substrate binding site [chemical binding]; other site 134676019640 activation loop (A-loop); other site 134676019641 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 134676019642 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 134676019643 active site 134676019644 substrate binding site [chemical binding]; other site 134676019645 metal binding site [ion binding]; metal-binding site 134676019646 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 134676019647 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 134676019648 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 134676019649 putative trimer interface [polypeptide binding]; other site 134676019650 putative active site [active] 134676019651 putative substrate binding site [chemical binding]; other site 134676019652 putative CoA binding site [chemical binding]; other site 134676019653 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 134676019654 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 134676019655 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 134676019656 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 134676019657 S-adenosylmethionine binding site [chemical binding]; other site 134676019658 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 134676019659 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 134676019660 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 134676019661 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 134676019662 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 134676019663 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 134676019664 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 134676019665 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 134676019666 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 134676019667 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 134676019668 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 134676019669 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 134676019670 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 134676019671 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 134676019672 inhibitor-cofactor binding pocket; inhibition site 134676019673 pyridoxal 5'-phosphate binding site [chemical binding]; other site 134676019674 catalytic residue [active] 134676019675 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 134676019676 putative active site [active] 134676019677 nucleotide binding site [chemical binding]; other site 134676019678 nudix motif; other site 134676019679 putative metal binding site [ion binding]; other site 134676019680 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 134676019681 active site 134676019682 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 134676019683 intersubunit interface [polypeptide binding]; other site 134676019684 active site 134676019685 catalytic residue [active] 134676019686 Aldehyde dehydrogenase family 16A1-like; Region: ALDH_F16; cd07111 134676019687 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 134676019688 NAD(P) binding site [chemical binding]; other site 134676019689 catalytic residues [active] 134676019690 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 134676019691 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 134676019692 NAD(P) binding site [chemical binding]; other site 134676019693 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK12323 134676019694 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 134676019695 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 134676019696 motif II; other site 134676019697 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 134676019698 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 134676019699 G1 box; other site 134676019700 GTP/Mg2+ binding site [chemical binding]; other site 134676019701 G2 box; other site 134676019702 Switch I region; other site 134676019703 G3 box; other site 134676019704 Switch II region; other site 134676019705 G4 box; other site 134676019706 G5 box; other site 134676019707 Protein of unknown function (DUF742); Region: DUF742; pfam05331 134676019708 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 134676019709 Nitrate and nitrite sensing; Region: NIT; pfam08376 134676019710 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 134676019711 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676019712 ATP binding site [chemical binding]; other site 134676019713 Mg2+ binding site [ion binding]; other site 134676019714 G-X-G motif; other site 134676019715 adenosine deaminase; Provisional; Region: PRK09358 134676019716 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 134676019717 active site 134676019718 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 134676019719 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 134676019720 Domain of unknown function (DUF4272); Region: DUF4272; pfam14094 134676019721 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 134676019722 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 134676019723 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 134676019724 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 134676019725 E3 interaction surface; other site 134676019726 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 134676019727 active site 134676019728 catalytic motif [active] 134676019729 Zn binding site [ion binding]; other site 134676019730 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 134676019731 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 134676019732 TM-ABC transporter signature motif; other site 134676019733 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 134676019734 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 134676019735 TM-ABC transporter signature motif; other site 134676019736 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 134676019737 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 134676019738 Walker A/P-loop; other site 134676019739 ATP binding site [chemical binding]; other site 134676019740 Q-loop/lid; other site 134676019741 ABC transporter signature motif; other site 134676019742 Walker B; other site 134676019743 D-loop; other site 134676019744 H-loop/switch region; other site 134676019745 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 134676019746 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 134676019747 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 134676019748 ligand binding site [chemical binding]; other site 134676019749 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 134676019750 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 134676019751 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 134676019752 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 134676019753 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 134676019754 active site 134676019755 HIGH motif; other site 134676019756 dimer interface [polypeptide binding]; other site 134676019757 KMSKS motif; other site 134676019758 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 134676019759 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 134676019760 NAD binding site [chemical binding]; other site 134676019761 homodimer interface [polypeptide binding]; other site 134676019762 active site 134676019763 substrate binding site [chemical binding]; other site 134676019764 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 134676019765 galactokinase; Provisional; Region: PRK00555 134676019766 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 134676019767 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 134676019768 Mg2+ binding site [ion binding]; other site 134676019769 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 134676019770 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 134676019771 CysD dimerization site [polypeptide binding]; other site 134676019772 G1 box; other site 134676019773 putative GEF interaction site [polypeptide binding]; other site 134676019774 GTP/Mg2+ binding site [chemical binding]; other site 134676019775 Switch I region; other site 134676019776 G2 box; other site 134676019777 G3 box; other site 134676019778 Switch II region; other site 134676019779 G4 box; other site 134676019780 G5 box; other site 134676019781 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 134676019782 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 134676019783 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 134676019784 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 134676019785 Active Sites [active] 134676019786 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 134676019787 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 134676019788 active site 134676019789 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 134676019790 Bacterial sugar transferase; Region: Bac_transf; pfam02397 134676019791 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 134676019792 putative active site [active] 134676019793 catalytic residue [active] 134676019794 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 134676019795 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 134676019796 5S rRNA interface [nucleotide binding]; other site 134676019797 CTC domain interface [polypeptide binding]; other site 134676019798 L16 interface [polypeptide binding]; other site 134676019799 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 134676019800 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 134676019801 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 134676019802 active site 134676019803 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 134676019804 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 134676019805 Substrate binding site; other site 134676019806 Mg++ binding site; other site 134676019807 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 134676019808 active site 134676019809 substrate binding site [chemical binding]; other site 134676019810 CoA binding site [chemical binding]; other site 134676019811 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 134676019812 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 134676019813 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676019814 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 134676019815 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 134676019816 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 134676019817 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 134676019818 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 134676019819 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 134676019820 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 134676019821 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 134676019822 active site 134676019823 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 134676019824 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 134676019825 active site 134676019826 HIGH motif; other site 134676019827 KMSKS motif; other site 134676019828 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 134676019829 tRNA binding surface [nucleotide binding]; other site 134676019830 anticodon binding site; other site 134676019831 Predicted methyltransferases [General function prediction only]; Region: COG0313 134676019832 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 134676019833 putative SAM binding site [chemical binding]; other site 134676019834 putative homodimer interface [polypeptide binding]; other site 134676019835 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 134676019836 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 134676019837 Catalytic NodB homology domain of uncharacterized bacterial glycosyl transferase, group 2-like family proteins; Region: CE4_GT2-like; cd10962 134676019838 NodB motif; other site 134676019839 putative active site [active] 134676019840 putative catalytic site [active] 134676019841 putative Zn binding site [ion binding]; other site 134676019842 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 134676019843 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 134676019844 DXD motif; other site 134676019845 GAF domain; Region: GAF; pfam01590 134676019846 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 134676019847 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 134676019848 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676019849 ATP binding site [chemical binding]; other site 134676019850 Mg2+ binding site [ion binding]; other site 134676019851 G-X-G motif; other site 134676019852 Uncharacterized protein conserved in bacteria (DUF2199); Region: DUF2199; cl02048 134676019853 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 134676019854 DNA binding site [nucleotide binding] 134676019855 Int/Topo IB signature motif; other site 134676019856 active site 134676019857 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 134676019858 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 134676019859 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 134676019860 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 134676019861 dimer interface [polypeptide binding]; other site 134676019862 putative functional site; other site 134676019863 putative MPT binding site; other site 134676019864 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 134676019865 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 134676019866 active site 134676019867 tetramer interface; other site 134676019868 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 134676019869 dimerization interface [polypeptide binding]; other site 134676019870 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 134676019871 GAF domain; Region: GAF; cl17456 134676019872 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 134676019873 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676019874 metal binding site [ion binding]; metal-binding site 134676019875 active site 134676019876 I-site; other site 134676019877 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 134676019878 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 134676019879 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 134676019880 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 134676019881 metal binding site 2 [ion binding]; metal-binding site 134676019882 putative DNA binding helix; other site 134676019883 metal binding site 1 [ion binding]; metal-binding site 134676019884 dimer interface [polypeptide binding]; other site 134676019885 structural Zn2+ binding site [ion binding]; other site 134676019886 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 134676019887 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 134676019888 MarC family integral membrane protein; Region: MarC; pfam01914 134676019889 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 134676019890 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 134676019891 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 134676019892 Bacterial PH domain; Region: DUF304; pfam03703 134676019893 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 134676019894 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 134676019895 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 134676019896 catalytic residues [active] 134676019897 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 134676019898 protein-splicing catalytic site; other site 134676019899 thioester formation/cholesterol transfer; other site 134676019900 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; cl16942 134676019901 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 134676019902 spore photoproduct lyase; Region: photo_TT_lyase; cl15393 134676019903 CoA binding domain; Region: CoA_binding; cl17356 134676019904 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 134676019905 classical (c) SDRs; Region: SDR_c; cd05233 134676019906 NAD(P) binding site [chemical binding]; other site 134676019907 active site 134676019908 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 134676019909 EamA-like transporter family; Region: EamA; pfam00892 134676019910 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 134676019911 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 134676019912 motif II; other site 134676019913 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 134676019914 MgtE intracellular N domain; Region: MgtE_N; smart00924 134676019915 FOG: CBS domain [General function prediction only]; Region: COG0517 134676019916 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 134676019917 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 134676019918 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 134676019919 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 134676019920 sec-independent translocase; Provisional; Region: tatB; PRK00182 134676019921 sec-independent translocase; Provisional; Region: PRK01371 134676019922 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 134676019923 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 134676019924 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 134676019925 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 134676019926 S-adenosylmethionine binding site [chemical binding]; other site 134676019927 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 134676019928 interface (dimer of trimers) [polypeptide binding]; other site 134676019929 Substrate-binding/catalytic site; other site 134676019930 Zn-binding sites [ion binding]; other site 134676019931 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 134676019932 PaaX-like protein; Region: PaaX; pfam07848 134676019933 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 134676019934 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 134676019935 enoyl-CoA hydratase; Provisional; Region: PRK06688 134676019936 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 134676019937 substrate binding site [chemical binding]; other site 134676019938 oxyanion hole (OAH) forming residues; other site 134676019939 trimer interface [polypeptide binding]; other site 134676019940 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 134676019941 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 134676019942 hydrophobic ligand binding site; other site 134676019943 DivIVA domain; Region: DivI1A_domain; TIGR03544 134676019944 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 134676019945 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 134676019946 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 134676019947 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 134676019948 dimer interface [polypeptide binding]; other site 134676019949 PYR/PP interface [polypeptide binding]; other site 134676019950 TPP binding site [chemical binding]; other site 134676019951 substrate binding site [chemical binding]; other site 134676019952 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 134676019953 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 134676019954 TPP-binding site [chemical binding]; other site 134676019955 Ion channel; Region: Ion_trans_2; pfam07885 134676019956 TrkA-N domain; Region: TrkA_N; pfam02254 134676019957 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 134676019958 cyclase homology domain; Region: CHD; cd07302 134676019959 nucleotidyl binding site; other site 134676019960 metal binding site [ion binding]; metal-binding site 134676019961 dimer interface [polypeptide binding]; other site 134676019962 Predicted ATPase [General function prediction only]; Region: COG3903 134676019963 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 134676019964 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 134676019965 dimer interface [polypeptide binding]; other site 134676019966 active site 134676019967 Schiff base residues; other site 134676019968 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 134676019969 active site 134676019970 homodimer interface [polypeptide binding]; other site 134676019971 SAM binding site [chemical binding]; other site 134676019972 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 134676019973 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 134676019974 active site 134676019975 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 134676019976 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 134676019977 domain interfaces; other site 134676019978 active site 134676019979 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 134676019980 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 134676019981 tRNA; other site 134676019982 putative tRNA binding site [nucleotide binding]; other site 134676019983 putative NADP binding site [chemical binding]; other site 134676019984 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 134676019985 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 134676019986 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 134676019987 CoA binding domain; Region: CoA_binding; smart00881 134676019988 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 134676019989 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 134676019990 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 134676019991 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 134676019992 acyl-activating enzyme (AAE) consensus motif; other site 134676019993 AMP binding site [chemical binding]; other site 134676019994 active site 134676019995 CoA binding site [chemical binding]; other site 134676019996 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 134676019997 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 134676019998 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 134676019999 DNA binding residues [nucleotide binding] 134676020000 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 134676020001 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 134676020002 putative acyl-acceptor binding pocket; other site 134676020003 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 134676020004 NAD(P) binding site [chemical binding]; other site 134676020005 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 134676020006 active site 134676020007 DNA binding domain, excisionase family; Region: excise; TIGR01764 134676020008 Proline dehydrogenase; Region: Pro_dh; cl03282 134676020009 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 134676020010 CGNR zinc finger; Region: zf-CGNR; pfam11706 134676020011 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 134676020012 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 134676020013 Metal-binding active site; metal-binding site 134676020014 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 134676020015 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676020016 active site 134676020017 phosphorylation site [posttranslational modification] 134676020018 intermolecular recognition site; other site 134676020019 dimerization interface [polypeptide binding]; other site 134676020020 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 134676020021 DNA binding site [nucleotide binding] 134676020022 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 134676020023 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 134676020024 dimer interface [polypeptide binding]; other site 134676020025 phosphorylation site [posttranslational modification] 134676020026 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676020027 ATP binding site [chemical binding]; other site 134676020028 Mg2+ binding site [ion binding]; other site 134676020029 G-X-G motif; other site 134676020030 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 134676020031 PhoU domain; Region: PhoU; pfam01895 134676020032 PhoU domain; Region: PhoU; pfam01895 134676020033 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 134676020034 catalytic core [active] 134676020035 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 134676020036 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 134676020037 Major Facilitator Superfamily; Region: MFS_1; pfam07690 134676020038 Major Facilitator Superfamily; Region: MFS_1; pfam07690 134676020039 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 134676020040 Major Facilitator Superfamily; Region: MFS_1; pfam07690 134676020041 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 134676020042 putative substrate translocation pore; other site 134676020043 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 134676020044 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 134676020045 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 134676020046 putative ADP-binding pocket [chemical binding]; other site 134676020047 malonic semialdehyde reductase; Provisional; Region: PRK10538 134676020048 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 134676020049 NAD(P) binding site [chemical binding]; other site 134676020050 active site 134676020051 flagellum gene cluster 134676020052 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676020053 Response regulator receiver domain; Region: Response_reg; pfam00072 134676020054 active site 134676020055 phosphorylation site [posttranslational modification] 134676020056 intermolecular recognition site; other site 134676020057 dimerization interface [polypeptide binding]; other site 134676020058 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 134676020059 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 134676020060 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 134676020061 calcium binding site 2 [ion binding]; other site 134676020062 active site 134676020063 catalytic triad [active] 134676020064 calcium binding site 1 [ion binding]; other site 134676020065 PAS domain; Region: PAS_8; pfam13188 134676020066 PAS domain S-box; Region: sensory_box; TIGR00229 134676020067 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 134676020068 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 134676020069 dimer interface [polypeptide binding]; other site 134676020070 phosphorylation site [posttranslational modification] 134676020071 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676020072 ATP binding site [chemical binding]; other site 134676020073 Mg2+ binding site [ion binding]; other site 134676020074 G-X-G motif; other site 134676020075 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 134676020076 putative hydrophobic ligand binding site [chemical binding]; other site 134676020077 carbon storage regulator; Provisional; Region: PRK01712 134676020078 FliW protein; Region: FliW; pfam02623 134676020079 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 134676020080 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 134676020081 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 134676020082 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 134676020083 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 134676020084 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 134676020085 FlgN protein; Region: FlgN; pfam05130 134676020086 flagellin; Reviewed; Region: PRK08869 134676020087 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 134676020088 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 134676020089 Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345 134676020090 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 134676020091 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 134676020092 Flagellar protein FliS; Region: FliS; cl00654 134676020093 Flagellar basal body protein [Cell motility and secretion]; Region: FlgB; COG1815 134676020094 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 134676020095 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 134676020096 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 134676020097 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 134676020098 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 134676020099 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 134676020100 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 134676020101 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 134676020102 FliG C-terminal domain; Region: FliG_C; pfam01706 134676020103 Flagellar assembly protein FliH; Region: FliH; pfam02108 134676020104 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 134676020105 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 134676020106 Walker A motif/ATP binding site; other site 134676020107 Walker B motif; other site 134676020108 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 134676020109 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 134676020110 NlpC/P60 family; Region: NLPC_P60; pfam00877 134676020111 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 134676020112 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 134676020113 N-acetyl-D-glucosamine binding site [chemical binding]; other site 134676020114 catalytic residue [active] 134676020115 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 134676020116 flagellar biosynthesis regulator FlhF; Provisional; Region: PRK12723 134676020117 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 134676020118 FHIPEP family; Region: FHIPEP; pfam00771 134676020119 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 134676020120 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 134676020121 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 134676020122 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 134676020123 flagellar motor switch protein FliN; Region: fliN; TIGR02480 134676020124 Flagellar motor switch protein FliM; Region: FliM; pfam02154 134676020125 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 134676020126 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 134676020127 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 134676020128 flagellar motor protein MotS; Reviewed; Region: PRK06925 134676020129 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 134676020130 ligand binding site [chemical binding]; other site 134676020131 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 134676020132 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 134676020133 Flagellar protein (FlbD); Region: FlbD; pfam06289 134676020134 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 134676020135 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 134676020136 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 134676020137 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 134676020138 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 134676020139 Response regulator receiver domain; Region: Response_reg; pfam00072 134676020140 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676020141 active site 134676020142 phosphorylation site [posttranslational modification] 134676020143 intermolecular recognition site; other site 134676020144 dimerization interface [polypeptide binding]; other site 134676020145 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 134676020146 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676020147 Response regulator receiver domain; Region: Response_reg; pfam00072 134676020148 active site 134676020149 phosphorylation site [posttranslational modification] 134676020150 intermolecular recognition site; other site 134676020151 dimerization interface [polypeptide binding]; other site 134676020152 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 134676020153 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 134676020154 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 134676020155 S-adenosylmethionine binding site [chemical binding]; other site 134676020156 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676020157 active site 134676020158 phosphorylation site [posttranslational modification] 134676020159 intermolecular recognition site; other site 134676020160 dimerization interface [polypeptide binding]; other site 134676020161 CheB methylesterase; Region: CheB_methylest; pfam01339 134676020162 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 134676020163 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 134676020164 putative binding surface; other site 134676020165 active site 134676020166 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 134676020167 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 134676020168 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676020169 ATP binding site [chemical binding]; other site 134676020170 Mg2+ binding site [ion binding]; other site 134676020171 G-X-G motif; other site 134676020172 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 134676020173 CheW-like domain; Region: CheW; pfam01584 134676020174 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 134676020175 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676020176 active site 134676020177 phosphorylation site [posttranslational modification] 134676020178 intermolecular recognition site; other site 134676020179 dimerization interface [polypeptide binding]; other site 134676020180 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 134676020181 DNA binding site [nucleotide binding] 134676020182 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 134676020183 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 134676020184 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 134676020185 FAD binding domain; Region: FAD_binding_4; pfam01565 134676020186 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 134676020187 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 134676020188 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 134676020189 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 134676020190 beta-galactosidase; Region: BGL; TIGR03356 134676020191 Transcriptional regulators [Transcription]; Region: PurR; COG1609 134676020192 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 134676020193 DNA binding site [nucleotide binding] 134676020194 domain linker motif; other site 134676020195 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 134676020196 putative dimerization interface [polypeptide binding]; other site 134676020197 putative ligand binding site [chemical binding]; other site 134676020198 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 134676020199 putative ADP-ribose binding site [chemical binding]; other site 134676020200 putative active site [active] 134676020201 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 134676020202 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 134676020203 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 134676020204 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 134676020205 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 134676020206 non-specific DNA binding site [nucleotide binding]; other site 134676020207 salt bridge; other site 134676020208 sequence-specific DNA binding site [nucleotide binding]; other site 134676020209 L-asparaginase II; Region: Asparaginase_II; pfam06089 134676020210 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 134676020211 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 134676020212 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 134676020213 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 134676020214 ferric uptake regulator; Provisional; Region: fur; PRK09462 134676020215 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 134676020216 metal binding site 2 [ion binding]; metal-binding site 134676020217 putative DNA binding helix; other site 134676020218 metal binding site 1 [ion binding]; metal-binding site 134676020219 dimer interface [polypeptide binding]; other site 134676020220 structural Zn2+ binding site [ion binding]; other site 134676020221 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 134676020222 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 134676020223 homodimer interface [polypeptide binding]; other site 134676020224 substrate-cofactor binding pocket; other site 134676020225 pyridoxal 5'-phosphate binding site [chemical binding]; other site 134676020226 catalytic residue [active] 134676020227 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 134676020228 heme-binding site [chemical binding]; other site 134676020229 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 134676020230 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 134676020231 nudix motif; other site 134676020232 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 134676020233 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 134676020234 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 134676020235 putative Mg++ binding site [ion binding]; other site 134676020236 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 134676020237 Protein of unknown function (DUF402); Region: DUF402; pfam04167 134676020238 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 134676020239 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 134676020240 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 134676020241 DNA binding residues [nucleotide binding] 134676020242 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 134676020243 active site 134676020244 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 134676020245 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 134676020246 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 134676020247 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 134676020248 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 134676020249 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 134676020250 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 134676020251 Walker A/P-loop; other site 134676020252 ATP binding site [chemical binding]; other site 134676020253 Q-loop/lid; other site 134676020254 ABC transporter signature motif; other site 134676020255 Walker B; other site 134676020256 D-loop; other site 134676020257 H-loop/switch region; other site 134676020258 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 134676020259 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 134676020260 dimer interface [polypeptide binding]; other site 134676020261 conserved gate region; other site 134676020262 putative PBP binding loops; other site 134676020263 ABC-ATPase subunit interface; other site 134676020264 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 134676020265 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 134676020266 dimer interface [polypeptide binding]; other site 134676020267 conserved gate region; other site 134676020268 putative PBP binding loops; other site 134676020269 ABC-ATPase subunit interface; other site 134676020270 PBP superfamily domain; Region: PBP_like_2; cl17296 134676020271 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 134676020272 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 134676020273 Coenzyme A binding pocket [chemical binding]; other site 134676020274 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 134676020275 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 134676020276 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 134676020277 DNA binding site [nucleotide binding] 134676020278 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 134676020279 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 134676020280 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 134676020281 active site residue [active] 134676020282 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 134676020283 active site residue [active] 134676020284 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 134676020285 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339 134676020286 Protease prsW family; Region: PrsW-protease; pfam13367 134676020287 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 134676020288 oligomerisation interface [polypeptide binding]; other site 134676020289 mobile loop; other site 134676020290 roof hairpin; other site 134676020291 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 134676020292 Domain of unknown function DUF20; Region: UPF0118; pfam01594 134676020293 Protein of unknown function (DUF4031); Region: DUF4031; pfam13223 134676020294 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 134676020295 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 134676020296 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 134676020297 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 134676020298 ring oligomerisation interface [polypeptide binding]; other site 134676020299 ATP/Mg binding site [chemical binding]; other site 134676020300 stacking interactions; other site 134676020301 hinge regions; other site 134676020302 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 134676020303 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 134676020304 threonine synthase; Validated; Region: PRK07591 134676020305 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 134676020306 homodimer interface [polypeptide binding]; other site 134676020307 pyridoxal 5'-phosphate binding site [chemical binding]; other site 134676020308 catalytic residue [active] 134676020309 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 134676020310 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 134676020311 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 134676020312 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 134676020313 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 134676020314 Walker A/P-loop; other site 134676020315 ATP binding site [chemical binding]; other site 134676020316 Q-loop/lid; other site 134676020317 ABC transporter signature motif; other site 134676020318 Walker B; other site 134676020319 D-loop; other site 134676020320 H-loop/switch region; other site 134676020321 Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359 134676020322 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 134676020323 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 134676020324 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 134676020325 Walker A motif; other site 134676020326 ATP binding site [chemical binding]; other site 134676020327 Walker B motif; other site 134676020328 arginine finger; other site 134676020329 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 134676020330 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 134676020331 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 134676020332 Walker A/P-loop; other site 134676020333 ATP binding site [chemical binding]; other site 134676020334 Q-loop/lid; other site 134676020335 ABC transporter signature motif; other site 134676020336 Walker B; other site 134676020337 D-loop; other site 134676020338 H-loop/switch region; other site 134676020339 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 134676020340 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 134676020341 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 134676020342 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 134676020343 dimer interface [polypeptide binding]; other site 134676020344 active site 134676020345 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 134676020346 N-acetylmannosamine kinase; Provisional; Region: PRK05082 134676020347 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 134676020348 nucleotide binding site [chemical binding]; other site 134676020349 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 134676020350 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 134676020351 active site 134676020352 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 134676020353 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 134676020354 Walker A/P-loop; other site 134676020355 ATP binding site [chemical binding]; other site 134676020356 Q-loop/lid; other site 134676020357 ABC transporter signature motif; other site 134676020358 Walker B; other site 134676020359 D-loop; other site 134676020360 H-loop/switch region; other site 134676020361 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 134676020362 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 134676020363 Histidine kinase; Region: HisKA_3; pfam07730 134676020364 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 134676020365 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676020366 active site 134676020367 phosphorylation site [posttranslational modification] 134676020368 intermolecular recognition site; other site 134676020369 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 134676020370 DNA binding residues [nucleotide binding] 134676020371 dimerization interface [polypeptide binding]; other site 134676020372 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 134676020373 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 134676020374 Transcriptional regulators [Transcription]; Region: MarR; COG1846 134676020375 MarR family; Region: MarR_2; pfam12802 134676020376 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 134676020377 active site 134676020378 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 134676020379 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 134676020380 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 134676020381 TrkA-N domain; Region: TrkA_N; pfam02254 134676020382 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 134676020383 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 134676020384 TrkA-N domain; Region: TrkA_N; pfam02254 134676020385 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 134676020386 Coenzyme A binding pocket [chemical binding]; other site 134676020387 PQQ-like domain; Region: PQQ_2; pfam13360 134676020388 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 134676020389 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 134676020390 Walker A/P-loop; other site 134676020391 ATP binding site [chemical binding]; other site 134676020392 Q-loop/lid; other site 134676020393 ABC transporter signature motif; other site 134676020394 Walker B; other site 134676020395 D-loop; other site 134676020396 H-loop/switch region; other site 134676020397 TOBE domain; Region: TOBE_2; pfam08402 134676020398 Family description; Region: VCBS; pfam13517 134676020399 Family description; Region: VCBS; pfam13517 134676020400 Family description; Region: VCBS; pfam13517 134676020401 Family description; Region: VCBS; pfam13517 134676020402 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl17442 134676020403 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 134676020404 protein-splicing catalytic site; other site 134676020405 thioester formation/cholesterol transfer; other site 134676020406 Pretoxin HINT domain; Region: PT-HINT; pfam07591 134676020407 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 134676020408 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 134676020409 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 134676020410 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 134676020411 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 134676020412 active site 134676020413 HIGH motif; other site 134676020414 nucleotide binding site [chemical binding]; other site 134676020415 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 134676020416 KMSKS motif; other site 134676020417 This DALR domain is found in cysteinyl-tRNA-synthetases; Region: DALR_2; smart00840 134676020418 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 134676020419 active site 134676020420 catalytic residues [active] 134676020421 fumarate hydratase; Reviewed; Region: fumC; PRK00485 134676020422 Class II fumarases; Region: Fumarase_classII; cd01362 134676020423 active site 134676020424 tetramer interface [polypeptide binding]; other site 134676020425 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 134676020426 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 134676020427 DNA binding site [nucleotide binding] 134676020428 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 134676020429 Tetratricopeptide repeat; Region: TPR_12; pfam13424 134676020430 fumarate hydratase; Provisional; Region: PRK15389 134676020431 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 134676020432 Fumarase C-terminus; Region: Fumerase_C; pfam05683 134676020433 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 134676020434 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 134676020435 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 134676020436 AsnC family; Region: AsnC_trans_reg; pfam01037 134676020437 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 134676020438 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 134676020439 dimer interface [polypeptide binding]; other site 134676020440 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 134676020441 active site 134676020442 Fe binding site [ion binding]; other site 134676020443 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 134676020444 RDD family; Region: RDD; pfam06271 134676020445 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 134676020446 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 134676020447 pyridoxal 5'-phosphate binding site [chemical binding]; other site 134676020448 homodimer interface [polypeptide binding]; other site 134676020449 catalytic residue [active] 134676020450 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 134676020451 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 134676020452 putative substrate translocation pore; other site 134676020453 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 134676020454 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 134676020455 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 134676020456 TPR motif; other site 134676020457 binding surface 134676020458 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Reviewed; Region: ispF; PRK00084 134676020459 homotrimer interaction site [polypeptide binding]; other site 134676020460 zinc binding site [ion binding]; other site 134676020461 CDP-binding sites; other site 134676020462 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 134676020463 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 134676020464 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 134676020465 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 134676020466 active site 134676020467 Methyltransferase domain; Region: Methyltransf_23; pfam13489 134676020468 Methyltransferase domain; Region: Methyltransf_11; pfam08241 134676020469 DNA repair protein RadA; Provisional; Region: PRK11823 134676020470 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 134676020471 Walker A motif; other site 134676020472 ATP binding site [chemical binding]; other site 134676020473 Walker B motif; other site 134676020474 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 134676020475 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 134676020476 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 134676020477 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 134676020478 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 134676020479 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 134676020480 endonuclease III; Region: ENDO3c; smart00478 134676020481 minor groove reading motif; other site 134676020482 helix-hairpin-helix signature motif; other site 134676020483 substrate binding pocket [chemical binding]; other site 134676020484 active site 134676020485 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 134676020486 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 134676020487 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 134676020488 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 134676020489 DNA binding residues [nucleotide binding] 134676020490 Domain of unknown function (DUF4291); Region: DUF4291; pfam14124 134676020491 Clp protease ATP binding subunit; Region: clpC; CHL00095 134676020492 Clp amino terminal domain; Region: Clp_N; pfam02861 134676020493 Clp amino terminal domain; Region: Clp_N; pfam02861 134676020494 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 134676020495 Walker A motif; other site 134676020496 ATP binding site [chemical binding]; other site 134676020497 Walker B motif; other site 134676020498 arginine finger; other site 134676020499 UvrB/uvrC motif; Region: UVR; pfam02151 134676020500 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 134676020501 Walker A motif; other site 134676020502 ATP binding site [chemical binding]; other site 134676020503 Walker B motif; other site 134676020504 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 134676020505 Lsr2; Region: Lsr2; pfam11774 134676020506 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 134676020507 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 134676020508 dimer interface [polypeptide binding]; other site 134676020509 putative anticodon binding site; other site 134676020510 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 134676020511 motif 1; other site 134676020512 dimer interface [polypeptide binding]; other site 134676020513 active site 134676020514 motif 2; other site 134676020515 motif 3; other site 134676020516 pantothenate kinase; Reviewed; Region: PRK13318 134676020517 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 134676020518 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 134676020519 dimerization interface [polypeptide binding]; other site 134676020520 active site 134676020521 L-aspartate oxidase; Provisional; Region: PRK07804 134676020522 L-aspartate oxidase; Provisional; Region: PRK06175 134676020523 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 134676020524 Septum formation; Region: Septum_form; pfam13845 134676020525 Septum formation; Region: Septum_form; pfam13845 134676020526 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 134676020527 tetramerization interface [polypeptide binding]; other site 134676020528 active site 134676020529 Pantoate-beta-alanine ligase; Region: PanC; cd00560 134676020530 pantoate--beta-alanine ligase; Region: panC; TIGR00018 134676020531 active site 134676020532 ATP-binding site [chemical binding]; other site 134676020533 pantoate-binding site; other site 134676020534 HXXH motif; other site 134676020535 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 134676020536 Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636 134676020537 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 134676020538 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 134676020539 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 134676020540 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 134676020541 ABC-ATPase subunit interface; other site 134676020542 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 134676020543 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 134676020544 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 134676020545 Walker A/P-loop; other site 134676020546 ATP binding site [chemical binding]; other site 134676020547 Q-loop/lid; other site 134676020548 ABC transporter signature motif; other site 134676020549 Walker B; other site 134676020550 D-loop; other site 134676020551 H-loop/switch region; other site 134676020552 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 134676020553 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 134676020554 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 134676020555 catalytic center binding site [active] 134676020556 ATP binding site [chemical binding]; other site 134676020557 Dihydroneopterin aldolase; Region: FolB; smart00905 134676020558 active site 134676020559 dihydropteroate synthase; Region: DHPS; TIGR01496 134676020560 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 134676020561 substrate binding pocket [chemical binding]; other site 134676020562 dimer interface [polypeptide binding]; other site 134676020563 inhibitor binding site; inhibition site 134676020564 AAA-like domain; Region: AAA_10; pfam12846 134676020565 Peptidase family M23; Region: Peptidase_M23; pfam01551 134676020566 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 134676020567 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 134676020568 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 134676020569 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 134676020570 homodecamer interface [polypeptide binding]; other site 134676020571 GTP cyclohydrolase I; Provisional; Region: PLN03044 134676020572 active site 134676020573 putative catalytic site residues [active] 134676020574 zinc binding site [ion binding]; other site 134676020575 GTP-CH-I/GFRP interaction surface; other site 134676020576 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 134676020577 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 134676020578 Walker A motif; other site 134676020579 ATP binding site [chemical binding]; other site 134676020580 Walker B motif; other site 134676020581 arginine finger; other site 134676020582 Peptidase family M41; Region: Peptidase_M41; pfam01434 134676020583 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 134676020584 active site 134676020585 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 134676020586 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 134676020587 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 134676020588 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 134676020589 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 134676020590 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 134676020591 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 134676020592 dimer interface [polypeptide binding]; other site 134676020593 substrate binding site [chemical binding]; other site 134676020594 metal binding sites [ion binding]; metal-binding site 134676020595 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 134676020596 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 134676020597 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 134676020598 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 134676020599 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 134676020600 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 134676020601 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 134676020602 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 134676020603 active site 134676020604 catalytic residues [active] 134676020605 Colicin V production protein; Region: Colicin_V; pfam02674 134676020606 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 134676020607 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 134676020608 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 134676020609 putative active site [active] 134676020610 putative CoA binding site [chemical binding]; other site 134676020611 nudix motif; other site 134676020612 metal binding site [ion binding]; metal-binding site 134676020613 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 134676020614 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 134676020615 catalytic residues [active] 134676020616 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 134676020617 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 134676020618 minor groove reading motif; other site 134676020619 helix-hairpin-helix signature motif; other site 134676020620 substrate binding pocket [chemical binding]; other site 134676020621 active site 134676020622 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 134676020623 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 134676020624 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 134676020625 putative active site [active] 134676020626 putative metal binding site [ion binding]; other site 134676020627 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 134676020628 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 134676020629 ligand binding site [chemical binding]; other site 134676020630 flexible hinge region; other site 134676020631 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 134676020632 non-specific DNA interactions [nucleotide binding]; other site 134676020633 DNA binding site [nucleotide binding] 134676020634 sequence specific DNA binding site [nucleotide binding]; other site 134676020635 putative cAMP binding site [chemical binding]; other site 134676020636 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 134676020637 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 134676020638 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 134676020639 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 134676020640 ATP-grasp domain; Region: ATP-grasp_4; cl17255 134676020641 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 134676020642 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 134676020643 carboxyltransferase (CT) interaction site; other site 134676020644 biotinylation site [posttranslational modification]; other site 134676020645 Catalytic domain of Protein Kinases; Region: PKc; cd00180 134676020646 Protein kinase domain; Region: Pkinase; pfam00069 134676020647 active site 134676020648 ATP binding site [chemical binding]; other site 134676020649 substrate binding site [chemical binding]; other site 134676020650 activation loop (A-loop); other site 134676020651 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 134676020652 cyclase homology domain; Region: CHD; cd07302 134676020653 nucleotidyl binding site; other site 134676020654 metal binding site [ion binding]; metal-binding site 134676020655 dimer interface [polypeptide binding]; other site 134676020656 AAA ATPase domain; Region: AAA_16; pfam13191 134676020657 Tetratricopeptide repeat; Region: TPR_12; pfam13424 134676020658 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 134676020659 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 134676020660 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 134676020661 homotrimer interaction site [polypeptide binding]; other site 134676020662 putative active site [active] 134676020663 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 134676020664 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 134676020665 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 134676020666 DTAP/Switch II; other site 134676020667 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 134676020668 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 134676020669 P loop; other site 134676020670 Nucleotide binding site [chemical binding]; other site 134676020671 DTAP/Switch II; other site 134676020672 Switch I; other site 134676020673 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 134676020674 Transcription factor WhiB; Region: Whib; pfam02467 134676020675 Transglycosylase; Region: Transgly; pfam00912 134676020676 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 134676020677 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 134676020678 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 134676020679 Yqey-like protein; Region: YqeY; cl17540 134676020680 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 134676020681 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 134676020682 putative active site [active] 134676020683 putative metal binding site [ion binding]; other site 134676020684 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 134676020685 active site 134676020686 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 134676020687 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 134676020688 aspartate kinase; Reviewed; Region: PRK06635 134676020689 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 134676020690 putative nucleotide binding site [chemical binding]; other site 134676020691 putative catalytic residues [active] 134676020692 putative Mg ion binding site [ion binding]; other site 134676020693 putative aspartate binding site [chemical binding]; other site 134676020694 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 134676020695 putative allosteric regulatory site; other site 134676020696 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 134676020697 putative allosteric regulatory residue; other site 134676020698 2-isopropylmalate synthase; Validated; Region: PRK03739 134676020699 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 134676020700 active site 134676020701 catalytic residues [active] 134676020702 metal binding site [ion binding]; metal-binding site 134676020703 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 134676020704 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 134676020705 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 134676020706 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 134676020707 Walker A/P-loop; other site 134676020708 ATP binding site [chemical binding]; other site 134676020709 Q-loop/lid; other site 134676020710 ABC transporter signature motif; other site 134676020711 Walker B; other site 134676020712 D-loop; other site 134676020713 H-loop/switch region; other site 134676020714 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 134676020715 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 134676020716 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 134676020717 Walker A/P-loop; other site 134676020718 ATP binding site [chemical binding]; other site 134676020719 Q-loop/lid; other site 134676020720 ABC transporter signature motif; other site 134676020721 Walker B; other site 134676020722 D-loop; other site 134676020723 H-loop/switch region; other site 134676020724 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 134676020725 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 134676020726 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 134676020727 dimer interface [polypeptide binding]; other site 134676020728 conserved gate region; other site 134676020729 putative PBP binding loops; other site 134676020730 ABC-ATPase subunit interface; other site 134676020731 The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506 134676020732 peptide binding site [polypeptide binding]; other site 134676020733 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 134676020734 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 134676020735 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 134676020736 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 134676020737 dimer interface [polypeptide binding]; other site 134676020738 conserved gate region; other site 134676020739 putative PBP binding loops; other site 134676020740 ABC-ATPase subunit interface; other site 134676020741 recombination protein RecR; Reviewed; Region: recR; PRK00076 134676020742 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 134676020743 RecR protein; Region: RecR; pfam02132 134676020744 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 134676020745 putative active site [active] 134676020746 putative metal-binding site [ion binding]; other site 134676020747 tetramer interface [polypeptide binding]; other site 134676020748 hypothetical protein; Validated; Region: PRK00153 134676020749 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 134676020750 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 134676020751 Walker A motif; other site 134676020752 ATP binding site [chemical binding]; other site 134676020753 Walker B motif; other site 134676020754 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 134676020755 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 134676020756 anti sigma factor interaction site; other site 134676020757 regulatory phosphorylation site [posttranslational modification]; other site 134676020758 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 134676020759 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 134676020760 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 134676020761 nucleoside/Zn binding site; other site 134676020762 dimer interface [polypeptide binding]; other site 134676020763 catalytic motif [active] 134676020764 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 134676020765 Peptidase family M23; Region: Peptidase_M23; pfam01551 134676020766 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 134676020767 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 134676020768 prephenate dehydrogenase; Validated; Region: PRK08507 134676020769 Protein of unknown function (DUF664); Region: DUF664; pfam04978 134676020770 DinB superfamily; Region: DinB_2; pfam12867 134676020771 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 134676020772 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 134676020773 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 134676020774 hypothetical protein; Provisional; Region: PRK07945 134676020775 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 134676020776 active site 134676020777 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 134676020778 HAMP domain; Region: HAMP; pfam00672 134676020779 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 134676020780 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676020781 ATP binding site [chemical binding]; other site 134676020782 G-X-G motif; other site 134676020783 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 134676020784 Protein of unknown function (DUF742); Region: DUF742; pfam05331 134676020785 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 134676020786 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 134676020787 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 134676020788 active site 134676020789 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 134676020790 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 134676020791 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 134676020792 active site 134676020793 homodimer interface [polypeptide binding]; other site 134676020794 Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG5298; cd10923 134676020795 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 134676020796 NodB motif; other site 134676020797 putative active site [active] 134676020798 putative catalytic site [active] 134676020799 putative Zn binding site [ion binding]; other site 134676020800 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 134676020801 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676020802 Cellulose binding domain; Region: CBM_2; pfam00553 134676020803 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 134676020804 active site 134676020805 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 134676020806 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 134676020807 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 134676020808 Major Facilitator Superfamily; Region: MFS_1; pfam07690 134676020809 putative substrate translocation pore; other site 134676020810 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 134676020811 Tetratricopeptide repeat; Region: TPR_12; pfam13424 134676020812 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 134676020813 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676020814 metal binding site [ion binding]; metal-binding site 134676020815 active site 134676020816 I-site; other site 134676020817 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 134676020818 Domain of unknown function (DUF397); Region: DUF397; pfam04149 134676020819 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 134676020820 non-specific DNA binding site [nucleotide binding]; other site 134676020821 salt bridge; other site 134676020822 sequence-specific DNA binding site [nucleotide binding]; other site 134676020823 Predicted transcriptional regulators [Transcription]; Region: COG1733 134676020824 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 134676020825 dimerization interface [polypeptide binding]; other site 134676020826 putative DNA binding site [nucleotide binding]; other site 134676020827 putative Zn2+ binding site [ion binding]; other site 134676020828 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 134676020829 putative FMN binding site [chemical binding]; other site 134676020830 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 134676020831 ATP binding site [chemical binding]; other site 134676020832 active site 134676020833 substrate binding site [chemical binding]; other site 134676020834 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 134676020835 active site 134676020836 PQQ-like domain; Region: PQQ_2; pfam13360 134676020837 Domain of unknown function (DUF305); Region: DUF305; pfam03713 134676020838 Chitin binding domain; Region: Chitin_bind_3; pfam03067 134676020839 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 134676020840 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 134676020841 dimerization interface [polypeptide binding]; other site 134676020842 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676020843 ATP binding site [chemical binding]; other site 134676020844 Mg2+ binding site [ion binding]; other site 134676020845 G-X-G motif; other site 134676020846 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 134676020847 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676020848 active site 134676020849 phosphorylation site [posttranslational modification] 134676020850 intermolecular recognition site; other site 134676020851 dimerization interface [polypeptide binding]; other site 134676020852 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 134676020853 DNA binding site [nucleotide binding] 134676020854 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 134676020855 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 134676020856 active site 134676020857 Zn binding site [ion binding]; other site 134676020858 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 134676020859 BioY family; Region: BioY; pfam02632 134676020860 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 134676020861 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 134676020862 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 134676020863 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 134676020864 dimerization interface [polypeptide binding]; other site 134676020865 putative DNA binding site [nucleotide binding]; other site 134676020866 putative Zn2+ binding site [ion binding]; other site 134676020867 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 134676020868 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 134676020869 active site 134676020870 catalytic tetrad [active] 134676020871 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 134676020872 Walker A/P-loop; other site 134676020873 ATP binding site [chemical binding]; other site 134676020874 ABC transporter; Region: ABC_tran; pfam00005 134676020875 Q-loop/lid; other site 134676020876 ABC transporter signature motif; other site 134676020877 Walker B; other site 134676020878 D-loop; other site 134676020879 H-loop/switch region; other site 134676020880 Putative zinc-finger; Region: zf-HC2; pfam13490 134676020881 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 134676020882 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 134676020883 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 134676020884 DNA binding residues [nucleotide binding] 134676020885 TfoX N-terminal domain; Region: TfoX_N; cl17592 134676020886 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 134676020887 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 134676020888 Metal-binding active site; metal-binding site 134676020889 Protein of unknown function (DUF993); Region: DUF993; pfam06187 134676020890 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 134676020891 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 134676020892 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 134676020893 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 134676020894 molybdopterin cofactor binding site; other site 134676020895 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 134676020896 molybdopterin cofactor binding site; other site 134676020897 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 134676020898 Flavodoxin; Region: Flavodoxin_1; pfam00258 134676020899 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 134676020900 FAD binding pocket [chemical binding]; other site 134676020901 FAD binding motif [chemical binding]; other site 134676020902 catalytic residues [active] 134676020903 NAD binding pocket [chemical binding]; other site 134676020904 phosphate binding motif [ion binding]; other site 134676020905 beta-alpha-beta structure motif; other site 134676020906 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 134676020907 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 134676020908 dimer interface [polypeptide binding]; other site 134676020909 active site 134676020910 heme binding site [chemical binding]; other site 134676020911 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 134676020912 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 134676020913 Beta-lactamase; Region: Beta-lactamase; pfam00144 134676020914 thymidine kinase; Provisional; Region: PRK04296 134676020915 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 134676020916 rod shape-determining protein MreB; Provisional; Region: PRK13930 134676020917 nucleotide binding site [chemical binding]; other site 134676020918 putative NEF/HSP70 interaction site [polypeptide binding]; other site 134676020919 SBD interface [polypeptide binding]; other site 134676020920 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 134676020921 uncharacterized phage protein; Region: phage_xxxx; TIGR02642 134676020922 CHY zinc finger; Region: zf-CHY; pfam05495 134676020923 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 134676020924 G1 box; other site 134676020925 GTP/Mg2+ binding site [chemical binding]; other site 134676020926 G2 box; other site 134676020927 Switch I region; other site 134676020928 G3 box; other site 134676020929 Switch II region; other site 134676020930 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 134676020931 cleavage site 134676020932 active site 134676020933 substrate binding sites [chemical binding]; other site 134676020934 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 134676020935 Helix-turn-helix domain; Region: HTH_38; pfam13936 134676020936 MarR family; Region: MarR_2; pfam12802 134676020937 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 134676020938 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 134676020939 active site 134676020940 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 134676020941 aromatic chitin/cellulose binding site residues [chemical binding]; other site 134676020942 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 134676020943 aromatic chitin/cellulose binding site residues [chemical binding]; other site 134676020944 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 134676020945 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 134676020946 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 134676020947 TQXA domain; Region: TQXA_dom; TIGR03934 134676020948 enolase; Provisional; Region: eno; PRK00077 134676020949 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 134676020950 dimer interface [polypeptide binding]; other site 134676020951 metal binding site [ion binding]; metal-binding site 134676020952 substrate binding pocket [chemical binding]; other site 134676020953 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 134676020954 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 134676020955 DNA binding residues [nucleotide binding] 134676020956 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 134676020957 Helix-turn-helix domain; Region: HTH_18; pfam12833 134676020958 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 134676020959 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 134676020960 dimer interface [polypeptide binding]; other site 134676020961 phosphorylation site [posttranslational modification] 134676020962 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676020963 ATP binding site [chemical binding]; other site 134676020964 Mg2+ binding site [ion binding]; other site 134676020965 G-X-G motif; other site 134676020966 Response regulator receiver domain; Region: Response_reg; pfam00072 134676020967 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676020968 active site 134676020969 phosphorylation site [posttranslational modification] 134676020970 intermolecular recognition site; other site 134676020971 dimerization interface [polypeptide binding]; other site 134676020972 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 134676020973 anti sigma factor interaction site; other site 134676020974 regulatory phosphorylation site [posttranslational modification]; other site 134676020975 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 134676020976 Transposase; Region: HTH_Tnp_1; cl17663 134676020977 HTH-like domain; Region: HTH_21; pfam13276 134676020978 Integrase core domain; Region: rve; pfam00665 134676020979 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 134676020980 Winged helix-turn helix; Region: HTH_29; pfam13551 134676020981 Integrase core domain; Region: rve; pfam00665 134676020982 Integrase core domain; Region: rve_3; pfam13683 134676020983 Integrase core domain; Region: rve_3; pfam13683 134676020984 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 134676020985 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 134676020986 nudix motif; other site 134676020987 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 134676020988 S-adenosylmethionine binding site [chemical binding]; other site 134676020989 Part of AAA domain; Region: AAA_19; pfam13245 134676020990 AAA domain; Region: AAA_11; pfam13086 134676020991 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 134676020992 AAA domain; Region: AAA_12; pfam13087 134676020993 PLD-like domain; Region: PLDc_2; pfam13091 134676020994 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 134676020995 putative active site [active] 134676020996 catalytic site [active] 134676020997 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 134676020998 active site 134676020999 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 134676021000 ABC transporter signature motif; other site 134676021001 AAA domain; Region: AAA_21; pfam13304 134676021002 Walker B; other site 134676021003 D-loop; other site 134676021004 H-loop/switch region; other site 134676021005 CAAX protease self-immunity; Region: Abi; pfam02517 134676021006 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 134676021007 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 134676021008 heme-binding site [chemical binding]; other site 134676021009 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 134676021010 FAD binding pocket [chemical binding]; other site 134676021011 FAD binding motif [chemical binding]; other site 134676021012 phosphate binding motif [ion binding]; other site 134676021013 beta-alpha-beta structure motif; other site 134676021014 NAD binding pocket [chemical binding]; other site 134676021015 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 134676021016 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 134676021017 non-specific DNA binding site [nucleotide binding]; other site 134676021018 salt bridge; other site 134676021019 sequence-specific DNA binding site [nucleotide binding]; other site 134676021020 Polypeptide deformylase; Region: Pep_deformylase; pfam01327 134676021021 active site 134676021022 catalytic residues [active] 134676021023 metal binding site [ion binding]; metal-binding site 134676021024 siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951 134676021025 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131 134676021026 Methyltransferase domain; Region: Methyltransf_23; pfam13489 134676021027 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 134676021028 S-adenosylmethionine binding site [chemical binding]; other site 134676021029 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 134676021030 substrate binding site [chemical binding]; other site 134676021031 NlpC/P60 family; Region: NLPC_P60; cl17555 134676021032 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 134676021033 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 134676021034 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 134676021035 NAD(P) binding site [chemical binding]; other site 134676021036 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 134676021037 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 134676021038 DNA binding residues [nucleotide binding] 134676021039 dimer interface [polypeptide binding]; other site 134676021040 [2Fe-2S] cluster binding site [ion binding]; other site 134676021041 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 134676021042 TPP-binding site [chemical binding]; other site 134676021043 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 134676021044 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 134676021045 PYR/PP interface [polypeptide binding]; other site 134676021046 dimer interface [polypeptide binding]; other site 134676021047 TPP binding site [chemical binding]; other site 134676021048 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 134676021049 Rhomboid family; Region: Rhomboid; pfam01694 134676021050 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 134676021051 active site 134676021052 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 134676021053 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 134676021054 oligomer interface [polypeptide binding]; other site 134676021055 metal binding site [ion binding]; metal-binding site 134676021056 metal binding site [ion binding]; metal-binding site 134676021057 putative Cl binding site [ion binding]; other site 134676021058 basic sphincter; other site 134676021059 hydrophobic gate; other site 134676021060 periplasmic entrance; other site 134676021061 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 134676021062 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 134676021063 pyridoxal 5'-phosphate binding site [chemical binding]; other site 134676021064 homodimer interface [polypeptide binding]; other site 134676021065 catalytic residue [active] 134676021066 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 134676021067 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 134676021068 active site 134676021069 metal-binding site 134676021070 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 134676021071 Glycerol-1-phosphate dehydrogenase-like; Region: G1PDH-like; cd08174 134676021072 active site 134676021073 metal binding site [ion binding]; metal-binding site 134676021074 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 134676021075 Arylsulfotransferase (ASST); Region: Arylsulfotran_2; pfam14269 134676021076 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 134676021077 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 134676021078 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 134676021079 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 134676021080 putative DNA binding site [nucleotide binding]; other site 134676021081 putative catalytic residues [active] 134676021082 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 134676021083 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 134676021084 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 134676021085 Bacterial sugar transferase; Region: Bac_transf; pfam02397 134676021086 translocation protein TolB; Provisional; Region: tolB; PRK00178 134676021087 Histidine kinase; Region: His_kinase; pfam06580 134676021088 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676021089 ATP binding site [chemical binding]; other site 134676021090 Mg2+ binding site [ion binding]; other site 134676021091 G-X-G motif; other site 134676021092 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 134676021093 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676021094 active site 134676021095 phosphorylation site [posttranslational modification] 134676021096 intermolecular recognition site; other site 134676021097 dimerization interface [polypeptide binding]; other site 134676021098 LytTr DNA-binding domain; Region: LytTR; smart00850 134676021099 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 134676021100 active site 134676021101 phosphorylation site [posttranslational modification] 134676021102 intermolecular recognition site; other site 134676021103 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 134676021104 dimerization interface [polypeptide binding]; other site 134676021105 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 134676021106 DNA binding site [nucleotide binding] 134676021107 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 134676021108 dimerization interface [polypeptide binding]; other site 134676021109 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 134676021110 dimer interface [polypeptide binding]; other site 134676021111 phosphorylation site [posttranslational modification] 134676021112 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676021113 ATP binding site [chemical binding]; other site 134676021114 Mg2+ binding site [ion binding]; other site 134676021115 G-X-G motif; other site 134676021116 Domain of unknown function (DUF4173); Region: DUF4173; pfam13777 134676021117 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 134676021118 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 134676021119 Na binding site [ion binding]; other site 134676021120 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 134676021121 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 134676021122 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 134676021123 Walker A/P-loop; other site 134676021124 ATP binding site [chemical binding]; other site 134676021125 Q-loop/lid; other site 134676021126 ABC transporter signature motif; other site 134676021127 Walker B; other site 134676021128 D-loop; other site 134676021129 H-loop/switch region; other site 134676021130 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 134676021131 Protein of unknown function, DUF485; Region: DUF485; pfam04341 134676021132 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 134676021133 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 134676021134 Na binding site [ion binding]; other site 134676021135 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 134676021136 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 134676021137 active site residue [active] 134676021138 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 134676021139 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 134676021140 active site 134676021141 catalytic site [active] 134676021142 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 134676021143 dimer interface [polypeptide binding]; other site 134676021144 phosphorylation site [posttranslational modification] 134676021145 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 134676021146 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 134676021147 ATP binding site [chemical binding]; other site 134676021148 Mg2+ binding site [ion binding]; other site 134676021149 G-X-G motif; other site 134676021150 arginine deiminase; Provisional; Region: PRK01388 134676021151 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 134676021152 PAS fold; Region: PAS; pfam00989 134676021153 Uncharacterized conserved protein [Function unknown]; Region: COG3603 134676021154 Family description; Region: ACT_7; pfam13840 134676021155 prephenate dehydratase; Provisional; Region: PRK11898 134676021156 Prephenate dehydratase; Region: PDT; pfam00800 134676021157 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 134676021158 putative L-Phe binding site [chemical binding]; other site 134676021159 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 134676021160 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 134676021161 seryl-tRNA synthetase; Provisional; Region: PRK05431 134676021162 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 134676021163 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 134676021164 dimer interface [polypeptide binding]; other site 134676021165 active site 134676021166 motif 1; other site 134676021167 motif 2; other site 134676021168 motif 3; other site 134676021169 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 134676021170 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 134676021171 active site 134676021172 motif I; other site 134676021173 motif II; other site 134676021174 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 134676021175 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 134676021176 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 134676021177 active site 134676021178 motif I; other site 134676021179 motif II; other site 134676021180 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 134676021181 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 134676021182 Amidinotransferase; Region: Amidinotransf; cl12043 134676021183 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 134676021184 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 134676021185 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 134676021186 AsnC family; Region: AsnC_trans_reg; pfam01037 134676021187 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 134676021188 active site 134676021189 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 134676021190 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 134676021191 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 134676021192 Coenzyme A binding pocket [chemical binding]; other site 134676021193 Phosphotransferase enzyme family; Region: APH; pfam01636 134676021194 Fructosamine kinase; Region: Fructosamin_kin; cl17579 134676021195 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 134676021196 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 134676021197 FeS/SAM binding site; other site 134676021198 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 134676021199 Ubiquitin-like proteins; Region: UBQ; cl00155 134676021200 charged pocket; other site 134676021201 hydrophobic patch; other site 134676021202 phosphodiesterase YaeI; Provisional; Region: PRK11340 134676021203 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 134676021204 putative active site [active] 134676021205 putative metal binding site [ion binding]; other site 134676021206 PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379 134676021207 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 134676021208 Part of AAA domain; Region: AAA_19; pfam13245 134676021209 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 134676021210 Family description; Region: UvrD_C_2; pfam13538 134676021211 AAA ATPase domain; Region: AAA_16; pfam13191 134676021212 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 134676021213 MoaE homodimer interface [polypeptide binding]; other site 134676021214 MoaD interaction [polypeptide binding]; other site 134676021215 active site residues [active] 134676021216 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 134676021217 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 134676021218 dimer interface [polypeptide binding]; other site 134676021219 putative functional site; other site 134676021220 putative MPT binding site; other site 134676021221 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 134676021222 MPT binding site; other site 134676021223 trimer interface [polypeptide binding]; other site 134676021224 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 134676021225 trimer interface [polypeptide binding]; other site 134676021226 dimer interface [polypeptide binding]; other site 134676021227 putative active site [active] 134676021228 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 134676021229 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 134676021230 metal binding site [ion binding]; metal-binding site 134676021231 active site 134676021232 I-site; other site 134676021233 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 134676021234 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 134676021235 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 134676021236 replicative DNA helicase; Region: DnaB; TIGR00665 134676021237 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 134676021238 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 134676021239 Walker A motif; other site 134676021240 ATP binding site [chemical binding]; other site 134676021241 Walker B motif; other site 134676021242 DNA binding loops [nucleotide binding] 134676021243 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK12323 134676021244 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 134676021245 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 134676021246 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 134676021247 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 134676021248 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 134676021249 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 134676021250 dimer interface [polypeptide binding]; other site 134676021251 ssDNA binding site [nucleotide binding]; other site 134676021252 tetramer (dimer of dimers) interface [polypeptide binding]; other site 134676021253 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 134676021254 endonuclease IV; Provisional; Region: PRK01060 134676021255 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 134676021256 AP (apurinic/apyrimidinic) site pocket; other site 134676021257 DNA interaction; other site 134676021258 Metal-binding active site; metal-binding site 134676021259 Competence protein; Region: Competence; cl00471 134676021260 Predicted integral membrane protein [Function unknown]; Region: COG5650 134676021261 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 134676021262 Transglycosylase; Region: Transgly; pfam00912 134676021263 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 134676021264 Predicted transcriptional regulators [Transcription]; Region: COG1695 134676021265 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 134676021266 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 134676021267 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 134676021268 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 134676021269 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 134676021270 putative active site [active] 134676021271 putative metal binding site [ion binding]; other site 134676021272 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 134676021273 dimerization interface [polypeptide binding]; other site 134676021274 poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012 134676021275 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 134676021276 Capsule biosynthesis CapC; Region: Caps_synth_CapC; pfam14102 134676021277 NlpC/P60 family; Region: NLPC_P60; cl17555 134676021278 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 134676021279 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 134676021280 DNA binding site [nucleotide binding] 134676021281 active site 134676021282 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 134676021283 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 134676021284 active site 134676021285 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 134676021286 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 134676021287 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 134676021288 DNA binding residues [nucleotide binding] 134676021289 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 134676021290 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 134676021291 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 134676021292 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 134676021293 active site 134676021294 NTP binding site [chemical binding]; other site 134676021295 metal binding triad [ion binding]; metal-binding site 134676021296 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 134676021297 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 134676021298 Zn2+ binding site [ion binding]; other site 134676021299 Mg2+ binding site [ion binding]; other site 134676021300 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 134676021301 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 134676021302 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 134676021303 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 134676021304 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 134676021305 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 134676021306 DNA binding residues [nucleotide binding] 134676021307 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 134676021308 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 134676021309 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 134676021310 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 134676021311 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 134676021312 catalytic residues [active] 134676021313 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 134676021314 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 134676021315 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 134676021316 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 134676021317 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 134676021318 active site 134676021319 metal binding site [ion binding]; metal-binding site 134676021320 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 134676021321 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 134676021322 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 134676021323 pyridoxal 5'-phosphate binding site [chemical binding]; other site 134676021324 homodimer interface [polypeptide binding]; other site 134676021325 catalytic residue [active] 134676021326 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 134676021327 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 134676021328 ATP-grasp domain; Region: ATP-grasp_4; cl17255 134676021329 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 134676021330 ParB-like nuclease domain; Region: ParBc; pfam02195 134676021331 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 134676021332 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 134676021333 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 134676021334 Magnesium ion binding site [ion binding]; other site 134676021335 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 134676021336 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 134676021337 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 134676021338 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 134676021339 G-X-X-G motif; other site 134676021340 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 134676021341 RxxxH motif; other site 134676021342 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 134676021343 putative inner membrane protein translocase component YidC; Provisional; Region: PRK01315 134676021344 Ribonuclease P; Region: Ribonuclease_P; cl00457 134676021345 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399