-- dump date 20140618_191330 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1246995000001 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 1246995000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1246995000003 Walker A motif; other site 1246995000004 ATP binding site [chemical binding]; other site 1246995000005 Walker B motif; other site 1246995000006 arginine finger; other site 1246995000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1246995000008 DnaA box-binding interface [nucleotide binding]; other site 1246995000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 1246995000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1246995000011 putative DNA binding surface [nucleotide binding]; other site 1246995000012 dimer interface [polypeptide binding]; other site 1246995000013 beta-clamp/clamp loader binding surface; other site 1246995000014 beta-clamp/translesion DNA polymerase binding surface; other site 1246995000015 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1246995000016 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 1246995000017 recombination protein F; Reviewed; Region: recF; PRK00064 1246995000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1246995000019 Walker A/P-loop; other site 1246995000020 ATP binding site [chemical binding]; other site 1246995000021 Q-loop/lid; other site 1246995000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995000023 ABC transporter signature motif; other site 1246995000024 Walker B; other site 1246995000025 D-loop; other site 1246995000026 H-loop/switch region; other site 1246995000027 Protein of unknown function (DUF721); Region: DUF721; cl02324 1246995000028 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1246995000029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995000030 Mg2+ binding site [ion binding]; other site 1246995000031 G-X-G motif; other site 1246995000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1246995000033 anchoring element; other site 1246995000034 dimer interface [polypeptide binding]; other site 1246995000035 ATP binding site [chemical binding]; other site 1246995000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1246995000037 active site 1246995000038 putative metal-binding site [ion binding]; other site 1246995000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1246995000040 DNA gyrase subunit A; Validated; Region: PRK05560 1246995000041 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1246995000042 CAP-like domain; other site 1246995000043 active site 1246995000044 primary dimer interface [polypeptide binding]; other site 1246995000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1246995000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1246995000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1246995000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1246995000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1246995000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1246995000051 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 1246995000052 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1246995000053 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1246995000054 Helix-turn-helix domain; Region: HTH_17; pfam12728 1246995000055 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 1246995000056 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1246995000057 S-adenosylmethionine binding site [chemical binding]; other site 1246995000058 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1246995000059 nudix motif; other site 1246995000060 PA2301 is an uncharacterized Pseudomonas aeruginosa protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's...; Region: PA2301; cd04939 1246995000061 putative deacylase active site [active] 1246995000062 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1246995000063 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1246995000064 Coenzyme A binding pocket [chemical binding]; other site 1246995000065 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1246995000066 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 1246995000067 catalytic residues [active] 1246995000068 Fe-S metabolism associated domain; Region: SufE; cl00951 1246995000069 FOG: CBS domain [General function prediction only]; Region: COG0517 1246995000070 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 1246995000071 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1246995000072 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1246995000073 dimer interface [polypeptide binding]; other site 1246995000074 motif 1; other site 1246995000075 active site 1246995000076 motif 2; other site 1246995000077 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1246995000078 putative deacylase active site [active] 1246995000079 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1246995000080 active site 1246995000081 motif 3; other site 1246995000082 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 1246995000083 anticodon binding site; other site 1246995000084 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 1246995000085 active site 1246995000086 catalytic triad [active] 1246995000087 oxyanion hole [active] 1246995000088 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1246995000089 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1246995000090 active site residue [active] 1246995000091 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1246995000092 active site residue [active] 1246995000093 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1246995000094 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995000095 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1246995000096 DNA binding residues [nucleotide binding] 1246995000097 Putative zinc-finger; Region: zf-HC2; pfam13490 1246995000098 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1246995000099 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 1246995000100 Walker A/P-loop; other site 1246995000101 ATP binding site [chemical binding]; other site 1246995000102 Q-loop/lid; other site 1246995000103 ABC transporter signature motif; other site 1246995000104 Walker B; other site 1246995000105 D-loop; other site 1246995000106 H-loop/switch region; other site 1246995000107 VanZ like family; Region: VanZ; pfam04892 1246995000108 HSP90 family protein; Provisional; Region: PRK14083 1246995000109 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995000110 ATP binding site [chemical binding]; other site 1246995000111 Mg2+ binding site [ion binding]; other site 1246995000112 G-X-G motif; other site 1246995000113 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995000114 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995000115 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1246995000116 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1246995000117 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1246995000118 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 1246995000119 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 1246995000120 active site 1246995000121 catalytic residues [active] 1246995000122 metal binding site [ion binding]; metal-binding site 1246995000123 ribonuclease E; Reviewed; Region: rne; PRK10811 1246995000124 Small secreted domain (DUF320); Region: DUF320; pfam03777 1246995000125 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1246995000126 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1246995000127 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1246995000128 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1246995000129 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1246995000130 active site 1246995000131 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1246995000132 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1246995000133 non-specific DNA binding site [nucleotide binding]; other site 1246995000134 salt bridge; other site 1246995000135 sequence-specific DNA binding site [nucleotide binding]; other site 1246995000136 AAA ATPase domain; Region: AAA_16; pfam13191 1246995000137 Predicted ATPase [General function prediction only]; Region: COG3903 1246995000138 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1246995000139 MarR family; Region: MarR; pfam01047 1246995000140 MarR family; Region: MarR_2; cl17246 1246995000141 Uncharacterized conserved protein [Function unknown]; Region: COG2353 1246995000142 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 1246995000143 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1246995000144 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1246995000145 sequence-specific DNA binding site [nucleotide binding]; other site 1246995000146 salt bridge; other site 1246995000147 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1246995000148 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1246995000149 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1246995000150 CDP-tyvelose 2-epimerase, extended (e) SDRs; Region: CDP_TE_SDR_e; cd05258 1246995000151 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1246995000152 NAD binding site [chemical binding]; other site 1246995000153 homotetramer interface [polypeptide binding]; other site 1246995000154 homodimer interface [polypeptide binding]; other site 1246995000155 active site 1246995000156 substrate binding site [chemical binding]; other site 1246995000157 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 1246995000158 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1246995000159 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1246995000160 phosphopeptide binding site; other site 1246995000161 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1246995000162 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1246995000163 phosphopeptide binding site; other site 1246995000164 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1246995000165 active site 1246995000166 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1246995000167 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1246995000168 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1246995000169 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1246995000170 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1246995000171 active site 1246995000172 ATP binding site [chemical binding]; other site 1246995000173 substrate binding site [chemical binding]; other site 1246995000174 activation loop (A-loop); other site 1246995000175 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1246995000176 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1246995000177 active site 1246995000178 ATP binding site [chemical binding]; other site 1246995000179 substrate binding site [chemical binding]; other site 1246995000180 activation loop (A-loop); other site 1246995000181 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1246995000182 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1246995000183 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1246995000184 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1246995000185 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1246995000186 glutamine binding [chemical binding]; other site 1246995000187 catalytic triad [active] 1246995000188 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 1246995000189 active site 1246995000190 catalytic site [active] 1246995000191 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1246995000192 Uncharacterized protein family (UPF0233); Region: UPF0233; pfam06781 1246995000193 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1246995000194 4Fe-4S binding domain; Region: Fer4; pfam00037 1246995000195 Cysteine-rich domain; Region: CCG; pfam02754 1246995000196 Cysteine-rich domain; Region: CCG; pfam02754 1246995000197 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 1246995000198 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1246995000199 Domain of unknown function DUF21; Region: DUF21; pfam01595 1246995000200 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1246995000201 Transporter associated domain; Region: CorC_HlyC; smart01091 1246995000202 Domain of unknown function DUF21; Region: DUF21; pfam01595 1246995000203 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1246995000204 FOG: CBS domain [General function prediction only]; Region: COG0517 1246995000205 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1246995000206 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 1246995000207 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1246995000208 DNA binding residues [nucleotide binding] 1246995000209 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1246995000210 sequence-specific DNA binding site [nucleotide binding]; other site 1246995000211 salt bridge; other site 1246995000212 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1246995000213 nudix motif; other site 1246995000214 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1246995000215 non-specific DNA binding site [nucleotide binding]; other site 1246995000216 salt bridge; other site 1246995000217 sequence-specific DNA binding site [nucleotide binding]; other site 1246995000218 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1246995000219 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1246995000220 trimer interface [polypeptide binding]; other site 1246995000221 active site 1246995000222 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1246995000223 YCII-related domain; Region: YCII; cl00999 1246995000224 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1246995000225 active site 1246995000226 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1246995000227 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1246995000228 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1246995000229 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1246995000230 active site 1246995000231 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1246995000232 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1246995000233 catalytic core [active] 1246995000234 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1246995000235 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 1246995000236 NADP binding site [chemical binding]; other site 1246995000237 Predicted transcriptional regulators [Transcription]; Region: COG1733 1246995000238 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1246995000239 dimerization interface [polypeptide binding]; other site 1246995000240 putative DNA binding site [nucleotide binding]; other site 1246995000241 putative Zn2+ binding site [ion binding]; other site 1246995000242 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1246995000243 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 1246995000244 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1246995000245 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1246995000246 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1246995000247 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1246995000248 transcription termination factor Rho; Provisional; Region: PRK12678 1246995000249 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 1246995000250 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1246995000251 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1246995000252 E3 interaction surface; other site 1246995000253 lipoyl attachment site [posttranslational modification]; other site 1246995000254 e3 binding domain; Region: E3_binding; pfam02817 1246995000255 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1246995000256 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1246995000257 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1246995000258 alpha subunit interface [polypeptide binding]; other site 1246995000259 TPP binding site [chemical binding]; other site 1246995000260 heterodimer interface [polypeptide binding]; other site 1246995000261 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1246995000262 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1246995000263 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1246995000264 TPP-binding site [chemical binding]; other site 1246995000265 heterodimer interface [polypeptide binding]; other site 1246995000266 tetramer interface [polypeptide binding]; other site 1246995000267 phosphorylation loop region [posttranslational modification] 1246995000268 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1246995000269 putative active site [active] 1246995000270 Dynamin family; Region: Dynamin_N; pfam00350 1246995000271 YfjP GTPase; Region: YfjP; cd11383 1246995000272 G1 box; other site 1246995000273 GTP/Mg2+ binding site [chemical binding]; other site 1246995000274 Switch I region; other site 1246995000275 G2 box; other site 1246995000276 Switch II region; other site 1246995000277 G3 box; other site 1246995000278 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1246995000279 G4 box; other site 1246995000280 G4 box; other site 1246995000281 G5 box; other site 1246995000282 G5 box; other site 1246995000283 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1246995000284 G1 box; other site 1246995000285 GTP/Mg2+ binding site [chemical binding]; other site 1246995000286 G2 box; other site 1246995000287 Switch I region; other site 1246995000288 G3 box; other site 1246995000289 Switch II region; other site 1246995000290 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1246995000291 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1246995000292 nucleotide binding site [chemical binding]; other site 1246995000293 NEF interaction site [polypeptide binding]; other site 1246995000294 SBD interface [polypeptide binding]; other site 1246995000295 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 1246995000296 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1246995000297 dimer interface [polypeptide binding]; other site 1246995000298 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1246995000299 chaperone protein DnaJ; Provisional; Region: PRK14292 1246995000300 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1246995000301 HSP70 interaction site [polypeptide binding]; other site 1246995000302 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1246995000303 Zn binding sites [ion binding]; other site 1246995000304 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1246995000305 dimer interface [polypeptide binding]; other site 1246995000306 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 1246995000307 DNA binding residues [nucleotide binding] 1246995000308 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1246995000309 putative dimer interface [polypeptide binding]; other site 1246995000310 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1246995000311 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1246995000312 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 1246995000313 TrkA-C domain; Region: TrkA_C; pfam02080 1246995000314 sugar efflux transporter; Region: 2A0120; TIGR00899 1246995000315 sugar efflux transporter B; Provisional; Region: PRK15011 1246995000316 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1246995000317 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1246995000318 Walker A motif; other site 1246995000319 ATP binding site [chemical binding]; other site 1246995000320 Walker B motif; other site 1246995000321 arginine finger; other site 1246995000322 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1246995000323 Walker A motif; other site 1246995000324 ATP binding site [chemical binding]; other site 1246995000325 Walker B motif; other site 1246995000326 arginine finger; other site 1246995000327 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1246995000328 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1246995000329 dimerization interface [polypeptide binding]; other site 1246995000330 putative DNA binding site [nucleotide binding]; other site 1246995000331 putative Zn2+ binding site [ion binding]; other site 1246995000332 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases [Carbohydrate transport and metabolism]; Region: AraD; COG0235 1246995000333 intersubunit interface [polypeptide binding]; other site 1246995000334 active site 1246995000335 Zn2+ binding site [ion binding]; other site 1246995000336 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1246995000337 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1246995000338 polynucleotide kinase-phosphatase; Region: bacter_Pnkp; TIGR04075 1246995000339 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995000340 Walker A/P-loop; other site 1246995000341 ATP binding site [chemical binding]; other site 1246995000342 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 1246995000343 active site 1246995000344 metal binding site [ion binding]; metal-binding site 1246995000345 RNA repair, ligase-Pnkp-associating, region of Hen1; Region: Hen1_L; pfam12623 1246995000346 3' terminal RNA ribose 2'-O-methyltransferase Hen1; Region: bacter_Hen1; TIGR04074 1246995000347 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 1246995000348 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995000349 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1246995000350 DNA binding residues [nucleotide binding] 1246995000351 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1246995000352 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1246995000353 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 1246995000354 active site 1246995000355 intersubunit interface [polypeptide binding]; other site 1246995000356 zinc binding site [ion binding]; other site 1246995000357 Na+ binding site [ion binding]; other site 1246995000358 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1246995000359 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 1246995000360 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 1246995000361 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1246995000362 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1246995000363 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1246995000364 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1246995000365 GDP-binding site [chemical binding]; other site 1246995000366 ACT binding site; other site 1246995000367 IMP binding site; other site 1246995000368 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1246995000369 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1246995000370 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1246995000371 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1246995000372 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1246995000373 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1246995000374 dimerization interface [polypeptide binding]; other site 1246995000375 putative DNA binding site [nucleotide binding]; other site 1246995000376 putative Zn2+ binding site [ion binding]; other site 1246995000377 H+ Antiporter protein; Region: 2A0121; TIGR00900 1246995000378 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 1246995000379 adenylosuccinate lyase; Region: purB; TIGR00928 1246995000380 tetramer interface [polypeptide binding]; other site 1246995000381 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1246995000382 cleavage site 1246995000383 active site 1246995000384 substrate binding sites [chemical binding]; other site 1246995000385 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 1246995000386 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1246995000387 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1246995000388 putative active site [active] 1246995000389 catalytic triad [active] 1246995000390 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1246995000391 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1246995000392 dimerization interface [polypeptide binding]; other site 1246995000393 ATP binding site [chemical binding]; other site 1246995000394 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1246995000395 dimerization interface [polypeptide binding]; other site 1246995000396 ATP binding site [chemical binding]; other site 1246995000397 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1246995000398 amidophosphoribosyltransferase; Provisional; Region: PRK07847 1246995000399 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1246995000400 active site 1246995000401 tetramer interface [polypeptide binding]; other site 1246995000402 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1246995000403 active site 1246995000404 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1246995000405 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1246995000406 dimerization interface [polypeptide binding]; other site 1246995000407 putative ATP binding site [chemical binding]; other site 1246995000408 radical SAM/SPASM domain protein, GRRM system; Region: rSAM_GlyRichRpt; TIGR04261 1246995000409 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1246995000410 FeS/SAM binding site; other site 1246995000411 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1246995000412 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 1246995000413 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1246995000414 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1246995000415 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 1246995000416 NAD binding site [chemical binding]; other site 1246995000417 Phe binding site; other site 1246995000418 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 1246995000419 DNA binding residues [nucleotide binding] 1246995000420 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 1246995000421 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1246995000422 S-adenosylmethionine binding site [chemical binding]; other site 1246995000423 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 1246995000424 RNA 2'-phosphotransferase, Tpt1 / KptA family; Region: PTS_2-RNA; pfam01885 1246995000425 Protease prsW family; Region: PrsW-protease; pfam13367 1246995000426 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1246995000427 CoenzymeA binding site [chemical binding]; other site 1246995000428 subunit interaction site [polypeptide binding]; other site 1246995000429 PHB binding site; other site 1246995000430 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1246995000431 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1246995000432 anti sigma factor interaction site; other site 1246995000433 regulatory phosphorylation site [posttranslational modification]; other site 1246995000434 SGNH_hydrolase subfamily, similar to Ruminococcus flavefaciens XynB. Most likely a secreted hydrolase with xylanase activity. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from...; Region: XynB_like; cd01833 1246995000435 active site 1246995000436 catalytic triad [active] 1246995000437 oxyanion hole [active] 1246995000438 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 1246995000439 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995000440 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1246995000441 DNA binding residues [nucleotide binding] 1246995000442 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 1246995000443 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 1246995000444 SnoaL-like domain; Region: SnoaL_3; pfam13474 1246995000445 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1246995000446 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 1246995000447 DNA binding residues [nucleotide binding] 1246995000448 B12 binding domain; Region: B12-binding_2; pfam02607 1246995000449 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1246995000450 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 1246995000451 nudix motif; other site 1246995000452 phytoene desaturase; Region: crtI_fam; TIGR02734 1246995000453 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1246995000454 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1246995000455 substrate binding pocket [chemical binding]; other site 1246995000456 chain length determination region; other site 1246995000457 substrate-Mg2+ binding site; other site 1246995000458 catalytic residues [active] 1246995000459 aspartate-rich region 1; other site 1246995000460 active site lid residues [active] 1246995000461 aspartate-rich region 2; other site 1246995000462 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1246995000463 active site lid residues [active] 1246995000464 substrate binding pocket [chemical binding]; other site 1246995000465 catalytic residues [active] 1246995000466 substrate-Mg2+ binding site; other site 1246995000467 aspartate-rich region 1; other site 1246995000468 aspartate-rich region 2; other site 1246995000469 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 1246995000470 DNA photolyase; Region: DNA_photolyase; pfam00875 1246995000471 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1246995000472 Beta-lactamase; Region: Beta-lactamase; pfam00144 1246995000473 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 1246995000474 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1246995000475 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1246995000476 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1246995000477 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1246995000478 Mg2+ binding site [ion binding]; other site 1246995000479 G-X-G motif; other site 1246995000480 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 1246995000481 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1246995000482 anti sigma factor interaction site; other site 1246995000483 regulatory phosphorylation site [posttranslational modification]; other site 1246995000484 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1246995000485 iron-sulfur cluster [ion binding]; other site 1246995000486 [2Fe-2S] cluster binding site [ion binding]; other site 1246995000487 FAD binding domain; Region: FAD_binding_4; pfam01565 1246995000488 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1246995000489 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1246995000490 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1246995000491 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 1246995000492 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1246995000493 putative active site [active] 1246995000494 putative metal binding site [ion binding]; other site 1246995000495 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cd00110 1246995000496 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1246995000497 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1246995000498 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1246995000499 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1246995000500 PRC-barrel domain; Region: PRC; pfam05239 1246995000501 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 1246995000502 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995000503 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1246995000504 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1246995000505 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 1246995000506 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 1246995000507 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 1246995000508 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1246995000509 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1246995000510 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1246995000511 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1246995000512 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995000513 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995000514 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 1246995000515 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995000516 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1246995000517 DNA binding residues [nucleotide binding] 1246995000518 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 1246995000519 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1246995000520 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1246995000521 non-specific DNA binding site [nucleotide binding]; other site 1246995000522 salt bridge; other site 1246995000523 sequence-specific DNA binding site [nucleotide binding]; other site 1246995000524 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1246995000525 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1246995000526 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1246995000527 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1246995000528 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1246995000529 SEC-C motif; Region: SEC-C; pfam02810 1246995000530 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1246995000531 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1246995000532 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1246995000533 dimerization interface [polypeptide binding]; other site 1246995000534 HD domain; Region: HD_4; pfam13328 1246995000535 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1246995000536 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1246995000537 active site 1246995000538 catalytic tetrad [active] 1246995000539 Domain of unknown function (DUF4279); Region: DUF4279; pfam14106 1246995000540 Phosphotransferase enzyme family; Region: APH; pfam01636 1246995000541 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1246995000542 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1246995000543 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1246995000544 dimerization interface [polypeptide binding]; other site 1246995000545 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1246995000546 dimer interface [polypeptide binding]; other site 1246995000547 phosphorylation site [posttranslational modification] 1246995000548 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995000549 ATP binding site [chemical binding]; other site 1246995000550 Mg2+ binding site [ion binding]; other site 1246995000551 G-X-G motif; other site 1246995000552 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 1246995000553 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995000554 active site 1246995000555 phosphorylation site [posttranslational modification] 1246995000556 intermolecular recognition site; other site 1246995000557 dimerization interface [polypeptide binding]; other site 1246995000558 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1246995000559 DNA binding site [nucleotide binding] 1246995000560 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1246995000561 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1246995000562 Walker A/P-loop; other site 1246995000563 ATP binding site [chemical binding]; other site 1246995000564 Q-loop/lid; other site 1246995000565 ABC transporter signature motif; other site 1246995000566 Walker B; other site 1246995000567 D-loop; other site 1246995000568 H-loop/switch region; other site 1246995000569 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1246995000570 FtsX-like permease family; Region: FtsX; pfam02687 1246995000571 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1246995000572 dimer interface [polypeptide binding]; other site 1246995000573 putative CheW interface [polypeptide binding]; other site 1246995000574 transcription termination factor Rho; Provisional; Region: PRK12608 1246995000575 RNA binding site [nucleotide binding]; other site 1246995000576 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1246995000577 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1246995000578 Walker A motif; other site 1246995000579 ATP binding site [chemical binding]; other site 1246995000580 Walker B motif; other site 1246995000581 Fasciclin domain; Region: Fasciclin; cl02663 1246995000582 PGAP1-like protein; Region: PGAP1; pfam07819 1246995000583 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1246995000584 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 1246995000585 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1246995000586 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1246995000587 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1246995000588 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1246995000589 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1246995000590 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995000591 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995000592 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1246995000593 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1246995000594 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1246995000595 putative sugar binding sites [chemical binding]; other site 1246995000596 Q-X-W motif; other site 1246995000597 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 1246995000598 CGNR zinc finger; Region: zf-CGNR; pfam11706 1246995000599 Predicted integral membrane protein [Function unknown]; Region: COG5660 1246995000600 Putative zinc-finger; Region: zf-HC2; pfam13490 1246995000601 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1246995000602 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 1246995000603 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1246995000604 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1246995000605 anti sigma factor interaction site; other site 1246995000606 regulatory phosphorylation site [posttranslational modification]; other site 1246995000607 RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361 1246995000608 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1246995000609 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1246995000610 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1246995000611 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1246995000612 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1246995000613 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1246995000614 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1246995000615 dimer interface [polypeptide binding]; other site 1246995000616 phosphorylation site [posttranslational modification] 1246995000617 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995000618 ATP binding site [chemical binding]; other site 1246995000619 Mg2+ binding site [ion binding]; other site 1246995000620 G-X-G motif; other site 1246995000621 Response regulator receiver domain; Region: Response_reg; pfam00072 1246995000622 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995000623 active site 1246995000624 phosphorylation site [posttranslational modification] 1246995000625 intermolecular recognition site; other site 1246995000626 dimerization interface [polypeptide binding]; other site 1246995000627 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1246995000628 Predicted transcriptional regulators [Transcription]; Region: COG1695 1246995000629 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1246995000630 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1246995000631 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1246995000632 Walker A/P-loop; other site 1246995000633 ATP binding site [chemical binding]; other site 1246995000634 Q-loop/lid; other site 1246995000635 ABC transporter signature motif; other site 1246995000636 Walker B; other site 1246995000637 D-loop; other site 1246995000638 H-loop/switch region; other site 1246995000639 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 1246995000640 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1246995000641 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1246995000642 FAD binding domain; Region: FAD_binding_4; pfam01565 1246995000643 RibD C-terminal domain; Region: RibD_C; cl17279 1246995000644 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1246995000645 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1246995000646 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1246995000647 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1246995000648 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1246995000649 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1246995000650 active site 1246995000651 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1246995000652 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1246995000653 ATP binding site [chemical binding]; other site 1246995000654 Mg2+ binding site [ion binding]; other site 1246995000655 G-X-G motif; other site 1246995000656 GAF domain; Region: GAF; cl17456 1246995000657 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1246995000658 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1246995000659 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1246995000660 dimerization interface [polypeptide binding]; other site 1246995000661 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1246995000662 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1246995000663 dimerization interface [polypeptide binding]; other site 1246995000664 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1246995000665 dimerization interface [polypeptide binding]; other site 1246995000666 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1246995000667 dimerization interface [polypeptide binding]; other site 1246995000668 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1246995000669 dimerization interface [polypeptide binding]; other site 1246995000670 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1246995000671 dimerization interface [polypeptide binding]; other site 1246995000672 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1246995000673 dimerization interface [polypeptide binding]; other site 1246995000674 GAF domain; Region: GAF_2; pfam13185 1246995000675 GAF domain; Region: GAF; pfam01590 1246995000676 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1246995000677 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995000678 ATP binding site [chemical binding]; other site 1246995000679 Mg2+ binding site [ion binding]; other site 1246995000680 G-X-G motif; other site 1246995000681 Response regulator receiver domain; Region: Response_reg; pfam00072 1246995000682 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995000683 active site 1246995000684 phosphorylation site [posttranslational modification] 1246995000685 intermolecular recognition site; other site 1246995000686 dimerization interface [polypeptide binding]; other site 1246995000687 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995000688 Response regulator receiver domain; Region: Response_reg; pfam00072 1246995000689 active site 1246995000690 phosphorylation site [posttranslational modification] 1246995000691 intermolecular recognition site; other site 1246995000692 dimerization interface [polypeptide binding]; other site 1246995000693 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 1246995000694 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1246995000695 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1246995000696 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1246995000697 active site 1246995000698 metal binding site [ion binding]; metal-binding site 1246995000699 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1246995000700 anti sigma factor interaction site; other site 1246995000701 regulatory phosphorylation site [posttranslational modification]; other site 1246995000702 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1246995000703 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1246995000704 inhibitor-cofactor binding pocket; inhibition site 1246995000705 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1246995000706 catalytic residue [active] 1246995000707 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1246995000708 catalytic core [active] 1246995000709 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1246995000710 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1246995000711 catalytic residues [active] 1246995000712 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1246995000713 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1246995000714 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 1246995000715 ResB-like family; Region: ResB; pfam05140 1246995000716 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 1246995000717 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995000718 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1246995000719 Walker A/P-loop; other site 1246995000720 ATP binding site [chemical binding]; other site 1246995000721 Q-loop/lid; other site 1246995000722 ABC transporter signature motif; other site 1246995000723 Walker B; other site 1246995000724 D-loop; other site 1246995000725 H-loop/switch region; other site 1246995000726 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995000727 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1246995000728 Walker A/P-loop; other site 1246995000729 ATP binding site [chemical binding]; other site 1246995000730 Q-loop/lid; other site 1246995000731 ABC transporter signature motif; other site 1246995000732 Walker B; other site 1246995000733 D-loop; other site 1246995000734 H-loop/switch region; other site 1246995000735 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1246995000736 sequence-specific DNA binding site [nucleotide binding]; other site 1246995000737 salt bridge; other site 1246995000738 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1246995000739 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1246995000740 DNA binding site [nucleotide binding] 1246995000741 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1246995000742 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1246995000743 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1246995000744 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 1246995000745 putative metal binding site [ion binding]; other site 1246995000746 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 1246995000747 putative metal binding site [ion binding]; other site 1246995000748 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 1246995000749 putative metal binding site [ion binding]; other site 1246995000750 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 1246995000751 putative metal binding site [ion binding]; other site 1246995000752 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1246995000753 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1246995000754 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 1246995000755 active site 1246995000756 catalytic site [active] 1246995000757 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1246995000758 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1246995000759 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1246995000760 DNA binding site [nucleotide binding] 1246995000761 domain linker motif; other site 1246995000762 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1246995000763 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1246995000764 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995000765 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1246995000766 menaquinone biosynthesis decarboxylase, SCO4490 family; Region: mena_SCO4490; TIGR03701 1246995000767 prenyltransferase; Reviewed; Region: ubiA; PRK12888 1246995000768 UbiA prenyltransferase family; Region: UbiA; pfam01040 1246995000769 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 1246995000770 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995000771 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1246995000772 DNA binding residues [nucleotide binding] 1246995000773 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 1246995000774 Flavoprotein; Region: Flavoprotein; pfam02441 1246995000775 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 1246995000776 DNA binding residues [nucleotide binding] 1246995000777 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1246995000778 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1246995000779 putative DNA binding site [nucleotide binding]; other site 1246995000780 putative Zn2+ binding site [ion binding]; other site 1246995000781 AsnC family; Region: AsnC_trans_reg; pfam01037 1246995000782 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1246995000783 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1246995000784 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1246995000785 catalytic residue [active] 1246995000786 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 1246995000787 Zn binding site [ion binding]; other site 1246995000788 Putative glycolipid-binding; Region: Glycolipid_bind; pfam06475 1246995000789 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1246995000790 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1246995000791 ATP binding site [chemical binding]; other site 1246995000792 Mg++ binding site [ion binding]; other site 1246995000793 motif III; other site 1246995000794 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1246995000795 nucleotide binding region [chemical binding]; other site 1246995000796 ATP-binding site [chemical binding]; other site 1246995000797 NlpC/P60 family; Region: NLPC_P60; pfam00877 1246995000798 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1246995000799 putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700 1246995000800 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1246995000801 FeS/SAM binding site; other site 1246995000802 Peptidase M14 Carboxypeptidase T subfamily; Region: M14_CPT; cd03859 1246995000803 putative active site [active] 1246995000804 Zn binding site [ion binding]; other site 1246995000805 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1246995000806 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1246995000807 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1246995000808 metal binding site [ion binding]; metal-binding site 1246995000809 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1246995000810 dimerization interface [polypeptide binding]; other site 1246995000811 active site 1246995000812 Protein of unknown function (DUF4231); Region: DUF4231; pfam14015 1246995000813 WHG domain; Region: WHG; pfam13305 1246995000814 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 1246995000815 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1246995000816 putative binding site residues; other site 1246995000817 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1246995000818 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1246995000819 ABC-ATPase subunit interface; other site 1246995000820 dimer interface [polypeptide binding]; other site 1246995000821 putative PBP binding regions; other site 1246995000822 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1246995000823 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1246995000824 Walker A/P-loop; other site 1246995000825 ATP binding site [chemical binding]; other site 1246995000826 Q-loop/lid; other site 1246995000827 ABC transporter signature motif; other site 1246995000828 Walker B; other site 1246995000829 D-loop; other site 1246995000830 H-loop/switch region; other site 1246995000831 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1246995000832 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1246995000833 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1246995000834 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1246995000835 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1246995000836 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1246995000837 Walker A/P-loop; other site 1246995000838 ATP binding site [chemical binding]; other site 1246995000839 Q-loop/lid; other site 1246995000840 ABC transporter signature motif; other site 1246995000841 Walker B; other site 1246995000842 D-loop; other site 1246995000843 H-loop/switch region; other site 1246995000844 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1246995000845 putative DNA binding site [nucleotide binding]; other site 1246995000846 putative Zn2+ binding site [ion binding]; other site 1246995000847 putative acetyltransferase; Provisional; Region: PRK03624 1246995000848 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1246995000849 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1246995000850 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1246995000851 putative DNA binding site [nucleotide binding]; other site 1246995000852 dimerization interface [polypeptide binding]; other site 1246995000853 putative Zn2+ binding site [ion binding]; other site 1246995000854 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1246995000855 putative substrate translocation pore; other site 1246995000856 Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621 1246995000857 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 1246995000858 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1246995000859 Ligand binding site; other site 1246995000860 Putative Catalytic site; other site 1246995000861 DXD motif; other site 1246995000862 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 1246995000863 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 1246995000864 active site 1246995000865 substrate binding site [chemical binding]; other site 1246995000866 FMN binding site [chemical binding]; other site 1246995000867 putative catalytic residues [active] 1246995000868 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1246995000869 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1246995000870 active site 1246995000871 catalytic tetrad [active] 1246995000872 glycoside hydrolase family 64: laminaripentaose-producing, beta-1,3-glucanase (LPHase)-like; Region: GH64-LPHase-like; cd09216 1246995000873 substrate binding pocket [chemical binding]; other site 1246995000874 catalytic residues [active] 1246995000875 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1246995000876 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1246995000877 putative sugar binding sites [chemical binding]; other site 1246995000878 Q-X-W motif; other site 1246995000879 Uncharacterized conserved protein [Function unknown]; Region: COG4279 1246995000880 SWIM zinc finger; Region: SWIM; pfam04434 1246995000881 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 1246995000882 SNF2 Helicase protein; Region: DUF3670; pfam12419 1246995000883 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1246995000884 ATP binding site [chemical binding]; other site 1246995000885 putative Mg++ binding site [ion binding]; other site 1246995000886 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1246995000887 nucleotide binding region [chemical binding]; other site 1246995000888 ATP-binding site [chemical binding]; other site 1246995000889 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359 1246995000890 putative dimer interface [polypeptide binding]; other site 1246995000891 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1246995000892 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995000893 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1246995000894 menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699 1246995000895 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1246995000896 FeS/SAM binding site; other site 1246995000897 Domain of unknown function (DUF4253); Region: DUF4253; pfam14062 1246995000898 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1246995000899 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1246995000900 S-adenosylmethionine binding site [chemical binding]; other site 1246995000901 Uncharacterized protein conserved in archaea (DUF2099); Region: DUF2099; cl01645 1246995000902 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 1246995000903 NADH dehydrogenase subunit A; Validated; Region: PRK07928 1246995000904 NADH dehydrogenase subunit B; Validated; Region: PRK06411 1246995000905 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 1246995000906 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 1246995000907 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 1246995000908 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1246995000909 NADH dehydrogenase subunit E; Validated; Region: PRK07539 1246995000910 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1246995000911 putative dimer interface [polypeptide binding]; other site 1246995000912 [2Fe-2S] cluster binding site [ion binding]; other site 1246995000913 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 1246995000914 SLBB domain; Region: SLBB; pfam10531 1246995000915 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 1246995000916 NADH dehydrogenase subunit G; Validated; Region: PRK07860 1246995000917 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1246995000918 catalytic loop [active] 1246995000919 iron binding site [ion binding]; other site 1246995000920 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1246995000921 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1246995000922 molybdopterin cofactor binding site; other site 1246995000923 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 1246995000924 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1246995000925 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1246995000926 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 1246995000927 4Fe-4S binding domain; Region: Fer4; pfam00037 1246995000928 4Fe-4S binding domain; Region: Fer4; pfam00037 1246995000929 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 1246995000930 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 1246995000931 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1246995000932 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1246995000933 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1246995000934 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1246995000935 NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010 1246995000936 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1246995000937 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1246995000938 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1246995000939 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1246995000940 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1246995000941 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1246995000942 substrate binding pocket [chemical binding]; other site 1246995000943 chain length determination region; other site 1246995000944 substrate-Mg2+ binding site; other site 1246995000945 catalytic residues [active] 1246995000946 aspartate-rich region 1; other site 1246995000947 active site lid residues [active] 1246995000948 aspartate-rich region 2; other site 1246995000949 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1246995000950 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1246995000951 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1246995000952 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 1246995000953 Bacterial transcriptional regulator; Region: IclR; pfam01614 1246995000954 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 1246995000955 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995000956 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1246995000957 DNA binding residues [nucleotide binding] 1246995000958 Putative zinc-finger; Region: zf-HC2; pfam13490 1246995000959 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1246995000960 Membrane protein of unknown function; Region: DUF360; pfam04020 1246995000961 Protein of unknown function (DUF2984); Region: DUF2984; cl12752 1246995000962 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1246995000963 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1246995000964 Alcohol dehydrogenase-like; Region: PLN02740 1246995000965 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1246995000966 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1246995000967 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 1246995000968 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 1246995000969 acetyl-CoA synthetase; Provisional; Region: PRK00174 1246995000970 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1246995000971 active site 1246995000972 CoA binding site [chemical binding]; other site 1246995000973 acyl-activating enzyme (AAE) consensus motif; other site 1246995000974 AMP binding site [chemical binding]; other site 1246995000975 acetate binding site [chemical binding]; other site 1246995000976 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1246995000977 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1246995000978 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1246995000979 motif II; other site 1246995000980 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1246995000981 anti sigma factor interaction site; other site 1246995000982 regulatory phosphorylation site [posttranslational modification]; other site 1246995000983 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 1246995000984 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1246995000985 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1246995000986 ATP binding site [chemical binding]; other site 1246995000987 Walker B motif; other site 1246995000988 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 1246995000989 helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816 1246995000990 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 1246995000991 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1246995000992 ATP binding site [chemical binding]; other site 1246995000993 putative Mg++ binding site [ion binding]; other site 1246995000994 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1246995000995 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1246995000996 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1246995000997 anti sigma factor interaction site; other site 1246995000998 regulatory phosphorylation site [posttranslational modification]; other site 1246995000999 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1246995001000 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1246995001001 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 1246995001002 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 1246995001003 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1246995001004 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1246995001005 active site 1246995001006 interdomain interaction site; other site 1246995001007 putative metal-binding site [ion binding]; other site 1246995001008 nucleotide binding site [chemical binding]; other site 1246995001009 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1246995001010 domain I; other site 1246995001011 DNA binding groove [nucleotide binding] 1246995001012 phosphate binding site [ion binding]; other site 1246995001013 domain II; other site 1246995001014 domain III; other site 1246995001015 nucleotide binding site [chemical binding]; other site 1246995001016 catalytic site [active] 1246995001017 domain IV; other site 1246995001018 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1246995001019 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1246995001020 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1246995001021 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 1246995001022 FAD binding domain; Region: FAD_binding_4; pfam01565 1246995001023 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 1246995001024 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995001025 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995001026 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 1246995001027 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 1246995001028 dimer interface [polypeptide binding]; other site 1246995001029 active site 1246995001030 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1246995001031 substrate binding site [chemical binding]; other site 1246995001032 catalytic residue [active] 1246995001033 H+ Antiporter protein; Region: 2A0121; TIGR00900 1246995001034 thymidylate kinase; Validated; Region: tmk; PRK00698 1246995001035 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1246995001036 TMP-binding site; other site 1246995001037 ATP-binding site [chemical binding]; other site 1246995001038 DNA polymerase III subunit delta'; Validated; Region: PRK07940 1246995001039 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1246995001040 PSP1 C-terminal conserved region; Region: PSP1; cl00770 1246995001041 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1246995001042 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1246995001043 catalytic residues [active] 1246995001044 catalytic nucleophile [active] 1246995001045 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1246995001046 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1246995001047 YcxB-like protein; Region: YcxB; pfam14317 1246995001048 HAMP domain; Region: HAMP; pfam00672 1246995001049 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1246995001050 dimer interface [polypeptide binding]; other site 1246995001051 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1246995001052 putative CheW interface [polypeptide binding]; other site 1246995001053 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 1246995001054 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995001055 maltose O-acetyltransferase; Provisional; Region: PRK10092 1246995001056 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1246995001057 active site 1246995001058 substrate binding site [chemical binding]; other site 1246995001059 trimer interface [polypeptide binding]; other site 1246995001060 CoA binding site [chemical binding]; other site 1246995001061 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 1246995001062 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1246995001063 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1246995001064 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1246995001065 sequence-specific DNA binding site [nucleotide binding]; other site 1246995001066 salt bridge; other site 1246995001067 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 1246995001068 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 1246995001069 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1246995001070 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1246995001071 proposed catalytic triad [active] 1246995001072 conserved cys residue [active] 1246995001073 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1246995001074 nudix motif; other site 1246995001075 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 1246995001076 putative DNA binding site [nucleotide binding]; other site 1246995001077 putative homodimer interface [polypeptide binding]; other site 1246995001078 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1246995001079 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 1246995001080 active site 1246995001081 DNA binding site [nucleotide binding] 1246995001082 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 1246995001083 DNA binding site [nucleotide binding] 1246995001084 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 1246995001085 nucleotide binding site [chemical binding]; other site 1246995001086 Predicted transcriptional regulators [Transcription]; Region: COG1695 1246995001087 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1246995001088 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 1246995001089 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1246995001090 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1246995001091 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 1246995001092 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1246995001093 ATP binding site [chemical binding]; other site 1246995001094 putative Mg++ binding site [ion binding]; other site 1246995001095 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1246995001096 nucleotide binding region [chemical binding]; other site 1246995001097 ATP-binding site [chemical binding]; other site 1246995001098 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1246995001099 WYL domain; Region: WYL; pfam13280 1246995001100 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1246995001101 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1246995001102 motif II; other site 1246995001103 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1246995001104 DNA-binding site [nucleotide binding]; DNA binding site 1246995001105 RNA-binding motif; other site 1246995001106 Menaquinone biosynthesis; Region: VitK2_biosynth; cl17475 1246995001107 hypothetical protein; Provisional; Region: PRK08236 1246995001108 H+ Antiporter protein; Region: 2A0121; TIGR00900 1246995001109 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1246995001110 putative substrate translocation pore; other site 1246995001111 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 1246995001112 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1246995001113 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1246995001114 MarR family; Region: MarR; pfam01047 1246995001115 H+ Antiporter protein; Region: 2A0121; TIGR00900 1246995001116 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1246995001117 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1246995001118 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1246995001119 catalytic residue [active] 1246995001120 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1246995001121 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1246995001122 DNA-binding site [nucleotide binding]; DNA binding site 1246995001123 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1246995001124 cyanate transporter; Region: CynX; TIGR00896 1246995001125 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 1246995001126 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1246995001127 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 1246995001128 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 1246995001129 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995001130 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1246995001131 DNA binding residues [nucleotide binding] 1246995001132 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1246995001133 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1246995001134 Coenzyme A binding pocket [chemical binding]; other site 1246995001135 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 1246995001136 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1246995001137 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1246995001138 homodimer interface [polypeptide binding]; other site 1246995001139 catalytic residue [active] 1246995001140 phosphoserine aminotransferase; Provisional; Region: PRK03080 1246995001141 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1246995001142 catalytic residue [active] 1246995001143 citrate synthase 2; Provisional; Region: PRK12350 1246995001144 Citrate synthase; Region: Citrate_synt; pfam00285 1246995001145 oxalacetate binding site [chemical binding]; other site 1246995001146 citrylCoA binding site [chemical binding]; other site 1246995001147 coenzyme A binding site [chemical binding]; other site 1246995001148 catalytic triad [active] 1246995001149 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 1246995001150 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1246995001151 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1246995001152 enterobactin exporter EntS; Provisional; Region: PRK10489 1246995001153 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1246995001154 putative substrate translocation pore; other site 1246995001155 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 1246995001156 active site 1246995001157 catalytic residues [active] 1246995001158 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 1246995001159 putative FMN binding site [chemical binding]; other site 1246995001160 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1246995001161 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1246995001162 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1246995001163 active site 1246995001164 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 1246995001165 PspC domain; Region: PspC; pfam04024 1246995001166 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1246995001167 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1246995001168 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1246995001169 active site 1246995001170 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1246995001171 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1246995001172 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1246995001173 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995001174 Walker A/P-loop; other site 1246995001175 ATP binding site [chemical binding]; other site 1246995001176 Q-loop/lid; other site 1246995001177 ABC transporter signature motif; other site 1246995001178 Walker B; other site 1246995001179 D-loop; other site 1246995001180 H-loop/switch region; other site 1246995001181 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1246995001182 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1246995001183 ATP binding site [chemical binding]; other site 1246995001184 Mg2+ binding site [ion binding]; other site 1246995001185 G-X-G motif; other site 1246995001186 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1246995001187 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1246995001188 motif II; other site 1246995001189 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1246995001190 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1246995001191 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1246995001192 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1246995001193 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 1246995001194 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1246995001195 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1246995001196 Walker A/P-loop; other site 1246995001197 ATP binding site [chemical binding]; other site 1246995001198 Q-loop/lid; other site 1246995001199 ABC transporter signature motif; other site 1246995001200 Walker B; other site 1246995001201 D-loop; other site 1246995001202 H-loop/switch region; other site 1246995001203 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1246995001204 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995001205 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995001206 PAS domain S-box; Region: sensory_box; TIGR00229 1246995001207 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1246995001208 putative active site [active] 1246995001209 heme pocket [chemical binding]; other site 1246995001210 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1246995001211 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1246995001212 metal binding site [ion binding]; metal-binding site 1246995001213 active site 1246995001214 I-site; other site 1246995001215 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1246995001216 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; pfam03663 1246995001217 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 1246995001218 nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526 1246995001219 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1246995001220 active site 1246995001221 nucleotide binding site [chemical binding]; other site 1246995001222 HIGH motif; other site 1246995001223 KMSKS motif; other site 1246995001224 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 1246995001225 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 1246995001226 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1246995001227 putative active site [active] 1246995001228 metal binding site [ion binding]; metal-binding site 1246995001229 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1246995001230 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1246995001231 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1246995001232 metal binding site [ion binding]; metal-binding site 1246995001233 active site 1246995001234 I-site; other site 1246995001235 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1246995001236 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 1246995001237 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 1246995001238 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 1246995001239 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995001240 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1246995001241 DNA binding residues [nucleotide binding] 1246995001242 Putative zinc-finger; Region: zf-HC2; pfam13490 1246995001243 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1246995001244 Rhodanese Homology Domain; Region: RHOD; smart00450 1246995001245 active site residue [active] 1246995001246 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 1246995001247 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1246995001248 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1246995001249 active site 1246995001250 ATP binding site [chemical binding]; other site 1246995001251 substrate binding site [chemical binding]; other site 1246995001252 activation loop (A-loop); other site 1246995001253 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 1246995001254 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1246995001255 putative ADP-binding pocket [chemical binding]; other site 1246995001256 Domain of unknown function (DUF239); Region: DUF239; pfam03080 1246995001257 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 1246995001258 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995001259 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1246995001260 DNA binding residues [nucleotide binding] 1246995001261 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 1246995001262 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1246995001263 DNA binding residues [nucleotide binding] 1246995001264 Protein of unknown function, DUF393; Region: DUF393; pfam04134 1246995001265 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1246995001266 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1246995001267 TM-ABC transporter signature motif; other site 1246995001268 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1246995001269 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1246995001270 TM-ABC transporter signature motif; other site 1246995001271 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1246995001272 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1246995001273 Walker A/P-loop; other site 1246995001274 ATP binding site [chemical binding]; other site 1246995001275 Q-loop/lid; other site 1246995001276 ABC transporter signature motif; other site 1246995001277 Walker B; other site 1246995001278 D-loop; other site 1246995001279 H-loop/switch region; other site 1246995001280 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1246995001281 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1246995001282 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1246995001283 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1246995001284 Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270 1246995001285 Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270 1246995001286 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 1246995001287 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1246995001288 putative ligand binding site [chemical binding]; other site 1246995001289 Glycosyltransferase (GlcNAc); Region: GlcNAc; pfam11397 1246995001290 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1246995001291 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 1246995001292 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1246995001293 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1246995001294 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1246995001295 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1246995001296 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1246995001297 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1246995001298 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1246995001299 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1246995001300 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 1246995001301 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 1246995001302 Protein of unknown function (DUF690); Region: DUF690; cl04939 1246995001303 Right handed beta helix region; Region: Beta_helix; pfam13229 1246995001304 Right handed beta helix region; Region: Beta_helix; pfam13229 1246995001305 Right handed beta helix region; Region: Beta_helix; pfam13229 1246995001306 Right handed beta helix region; Region: Beta_helix; pfam13229 1246995001307 stage V sporulation protein K; Region: spore_V_K; TIGR02881 1246995001308 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1246995001309 Walker A motif; other site 1246995001310 ATP binding site [chemical binding]; other site 1246995001311 Walker B motif; other site 1246995001312 arginine finger; other site 1246995001313 stage V sporulation protein K; Region: spore_V_K; TIGR02881 1246995001314 hypothetical protein; Validated; Region: PRK00153 1246995001315 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1246995001316 DNA binding site [nucleotide binding] 1246995001317 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1246995001318 AAA ATPase domain; Region: AAA_16; pfam13191 1246995001319 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1246995001320 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1246995001321 TPR motif; other site 1246995001322 binding surface 1246995001323 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1246995001324 DNA binding site [nucleotide binding] 1246995001325 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1246995001326 AAA ATPase domain; Region: AAA_16; pfam13191 1246995001327 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995001328 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995001329 DNA binding residues [nucleotide binding] 1246995001330 dimerization interface [polypeptide binding]; other site 1246995001331 CESA_like_2 is a member of the cellulose synthase superfamily; Region: CESA_like_2; cd06427 1246995001332 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1246995001333 DXD motif; other site 1246995001334 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995001335 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995001336 WHG domain; Region: WHG; pfam13305 1246995001337 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 1246995001338 putative dimer interface [polypeptide binding]; other site 1246995001339 catalytic triad [active] 1246995001340 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1246995001341 putative substrate translocation pore; other site 1246995001342 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1246995001343 short chain dehydrogenase; Provisional; Region: PRK06523 1246995001344 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995001345 NAD(P) binding site [chemical binding]; other site 1246995001346 active site 1246995001347 Response regulator receiver domain; Region: Response_reg; pfam00072 1246995001348 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995001349 active site 1246995001350 phosphorylation site [posttranslational modification] 1246995001351 intermolecular recognition site; other site 1246995001352 dimerization interface [polypeptide binding]; other site 1246995001353 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1246995001354 non-specific DNA binding site [nucleotide binding]; other site 1246995001355 salt bridge; other site 1246995001356 sequence-specific DNA binding site [nucleotide binding]; other site 1246995001357 HipA N-terminal domain; Region: Couple_hipA; pfam13657 1246995001358 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1246995001359 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1246995001360 metal binding site [ion binding]; metal-binding site 1246995001361 active site 1246995001362 I-site; other site 1246995001363 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1246995001364 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria; Region: NTP-PPase_u1; cd11538 1246995001365 metal binding site [ion binding]; metal-binding site 1246995001366 pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590 1246995001367 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 1246995001368 ligand binding site; other site 1246995001369 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1246995001370 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1246995001371 inhibitor-cofactor binding pocket; inhibition site 1246995001372 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1246995001373 catalytic residue [active] 1246995001374 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 1246995001375 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995001376 NAD(P) binding site [chemical binding]; other site 1246995001377 active site 1246995001378 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 1246995001379 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1246995001380 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995001381 NAD(P) binding site [chemical binding]; other site 1246995001382 active site 1246995001383 AMP-binding enzyme; Region: AMP-binding; pfam00501 1246995001384 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1246995001385 active site 1246995001386 CoA binding site [chemical binding]; other site 1246995001387 AMP binding site [chemical binding]; other site 1246995001388 Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443 1246995001389 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1246995001390 NAD(P) binding site [chemical binding]; other site 1246995001391 catalytic residues [active] 1246995001392 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1246995001393 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1246995001394 Ligand binding site; other site 1246995001395 Putative Catalytic site; other site 1246995001396 DXD motif; other site 1246995001397 Domain of unknown function (DUF4180); Region: DUF4180; pfam13788 1246995001398 Helix-turn-helix domain; Region: HTH_17; pfam12728 1246995001399 Cupin domain; Region: Cupin_2; pfam07883 1246995001400 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1246995001401 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1246995001402 putative NAD(P) binding site [chemical binding]; other site 1246995001403 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1246995001404 MarR family; Region: MarR_2; pfam12802 1246995001405 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1246995001406 Beta-lactamase; Region: Beta-lactamase; pfam00144 1246995001407 Putative sensor; Region: Sensor; pfam13796 1246995001408 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1246995001409 Histidine kinase; Region: HisKA_3; pfam07730 1246995001410 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995001411 ATP binding site [chemical binding]; other site 1246995001412 Mg2+ binding site [ion binding]; other site 1246995001413 G-X-G motif; other site 1246995001414 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995001415 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995001416 active site 1246995001417 phosphorylation site [posttranslational modification] 1246995001418 intermolecular recognition site; other site 1246995001419 dimerization interface [polypeptide binding]; other site 1246995001420 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995001421 dimerization interface [polypeptide binding]; other site 1246995001422 DNA binding residues [nucleotide binding] 1246995001423 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1246995001424 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1246995001425 CsbD-like; Region: CsbD; cl17424 1246995001426 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1246995001427 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1246995001428 metal binding site [ion binding]; metal-binding site 1246995001429 active site 1246995001430 I-site; other site 1246995001431 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1246995001432 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1246995001433 active site 1246995001434 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1246995001435 pseudaminic acid synthase; Region: PseI; TIGR03586 1246995001436 NeuB family; Region: NeuB; pfam03102 1246995001437 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 1246995001438 NeuB binding interface [polypeptide binding]; other site 1246995001439 putative substrate binding site [chemical binding]; other site 1246995001440 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1246995001441 CrcB-like protein; Region: CRCB; pfam02537 1246995001442 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 1246995001443 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1246995001444 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995001445 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1246995001446 DNA binding residues [nucleotide binding] 1246995001447 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 1246995001448 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 1246995001449 Septum formation; Region: Septum_form; pfam13845 1246995001450 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1246995001451 GAF domain; Region: GAF; pfam01590 1246995001452 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1246995001453 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1246995001454 metal binding site [ion binding]; metal-binding site 1246995001455 active site 1246995001456 I-site; other site 1246995001457 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1246995001458 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1246995001459 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1246995001460 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1246995001461 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1246995001462 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1246995001463 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1246995001464 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995001465 dimer interface [polypeptide binding]; other site 1246995001466 conserved gate region; other site 1246995001467 putative PBP binding loops; other site 1246995001468 ABC-ATPase subunit interface; other site 1246995001469 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1246995001470 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995001471 dimer interface [polypeptide binding]; other site 1246995001472 conserved gate region; other site 1246995001473 putative PBP binding loops; other site 1246995001474 ABC-ATPase subunit interface; other site 1246995001475 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1246995001476 L-threonine dehydrogenase; Region: threonine_DH_like; cd08234 1246995001477 putative NAD(P) binding site [chemical binding]; other site 1246995001478 catalytic Zn binding site [ion binding]; other site 1246995001479 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1246995001480 MarR family; Region: MarR; pfam01047 1246995001481 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1246995001482 putative substrate translocation pore; other site 1246995001483 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1246995001484 putative substrate translocation pore; other site 1246995001485 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995001486 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995001487 TAP-like protein; Region: Abhydrolase_4; pfam08386 1246995001488 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 1246995001489 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1246995001490 Predicted membrane protein [Function unknown]; Region: COG2119 1246995001491 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1246995001492 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1246995001493 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 1246995001494 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1246995001495 TPR repeat; Region: TPR_11; pfam13414 1246995001496 binding surface 1246995001497 TPR motif; other site 1246995001498 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1246995001499 binding surface 1246995001500 TPR motif; other site 1246995001501 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1246995001502 binding surface 1246995001503 TPR motif; other site 1246995001504 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1246995001505 Predicted integral membrane protein [Function unknown]; Region: COG0392 1246995001506 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1246995001507 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 1246995001508 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995001509 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1246995001510 DNA binding residues [nucleotide binding] 1246995001511 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 1246995001512 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 1246995001513 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 1246995001514 active site 1246995001515 P-loop; other site 1246995001516 phosphorylation site [posttranslational modification] 1246995001517 MgtE intracellular N domain; Region: MgtE_N; pfam03448 1246995001518 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1246995001519 active site 1246995001520 phosphorylation site [posttranslational modification] 1246995001521 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206 1246995001522 regulatory phosphorylation site [posttranslational modification]; other site 1246995001523 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1246995001524 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1246995001525 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1246995001526 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1246995001527 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 1246995001528 SpoOM protein; Region: Spo0M; pfam07070 1246995001529 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1246995001530 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1246995001531 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1246995001532 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cd00110 1246995001533 Glyco_18 domain; Region: Glyco_18; smart00636 1246995001534 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 1246995001535 active site 1246995001536 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 1246995001537 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1246995001538 DDE superfamily endonuclease; Region: DDE_4; pfam13359 1246995001539 Predicted ATPase [General function prediction only]; Region: COG3903 1246995001540 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1246995001541 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1246995001542 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995001543 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1246995001544 Walker A/P-loop; other site 1246995001545 ATP binding site [chemical binding]; other site 1246995001546 Q-loop/lid; other site 1246995001547 ABC transporter signature motif; other site 1246995001548 Walker B; other site 1246995001549 D-loop; other site 1246995001550 H-loop/switch region; other site 1246995001551 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1246995001552 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995001553 NAD(P) binding site [chemical binding]; other site 1246995001554 active site 1246995001555 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1246995001556 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1246995001557 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 1246995001558 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1246995001559 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1246995001560 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 1246995001561 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 1246995001562 DNA polymerase Ligase (LigD); Region: LigD_N; pfam13298 1246995001563 Sulfatase; Region: Sulfatase; cl17466 1246995001564 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like; cd11354 1246995001565 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1246995001566 active site 1246995001567 catalytic site [active] 1246995001568 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 1246995001569 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995001570 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1246995001571 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1246995001572 DNA binding residues [nucleotide binding] 1246995001573 CopC domain; Region: CopC; pfam04234 1246995001574 Tubby C 2; Region: Tub_2; cl02043 1246995001575 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1246995001576 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1246995001577 NAD binding site [chemical binding]; other site 1246995001578 catalytic Zn binding site [ion binding]; other site 1246995001579 structural Zn binding site [ion binding]; other site 1246995001580 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1246995001581 classical (c) SDRs; Region: SDR_c; cd05233 1246995001582 NAD(P) binding site [chemical binding]; other site 1246995001583 active site 1246995001584 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1246995001585 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1246995001586 sequence-specific DNA binding site [nucleotide binding]; other site 1246995001587 salt bridge; other site 1246995001588 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1246995001589 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1246995001590 active site 1246995001591 catalytic tetrad [active] 1246995001592 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1246995001593 sugar binding site [chemical binding]; other site 1246995001594 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1246995001595 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1246995001596 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1246995001597 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1246995001598 dimerization interface [polypeptide binding]; other site 1246995001599 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1246995001600 dimer interface [polypeptide binding]; other site 1246995001601 putative CheW interface [polypeptide binding]; other site 1246995001602 Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398 1246995001603 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1246995001604 S-adenosylmethionine binding site [chemical binding]; other site 1246995001605 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1246995001606 putative substrate translocation pore; other site 1246995001607 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1246995001608 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1246995001609 S-adenosylmethionine binding site [chemical binding]; other site 1246995001610 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1246995001611 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1246995001612 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1246995001613 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1246995001614 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995001615 NAD(P) binding site [chemical binding]; other site 1246995001616 active site 1246995001617 serine hydroxymethyltransferase; Provisional; Region: PRK13580 1246995001618 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1246995001619 dimer interface [polypeptide binding]; other site 1246995001620 active site 1246995001621 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1246995001622 folate binding site [chemical binding]; other site 1246995001623 Major royal jelly protein; Region: MRJP; pfam03022 1246995001624 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1246995001625 active site 1246995001626 metal binding site [ion binding]; metal-binding site 1246995001627 homotetramer interface [polypeptide binding]; other site 1246995001628 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1246995001629 sugar binding site [chemical binding]; other site 1246995001630 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1246995001631 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1246995001632 DNA binding site [nucleotide binding] 1246995001633 domain linker motif; other site 1246995001634 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1246995001635 dimerization interface [polypeptide binding]; other site 1246995001636 ligand binding site [chemical binding]; other site 1246995001637 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1246995001638 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 1246995001639 ligand binding site [chemical binding]; other site 1246995001640 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1246995001641 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1246995001642 TM-ABC transporter signature motif; other site 1246995001643 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1246995001644 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995001645 Walker A/P-loop; other site 1246995001646 ATP binding site [chemical binding]; other site 1246995001647 Q-loop/lid; other site 1246995001648 ABC transporter signature motif; other site 1246995001649 Walker B; other site 1246995001650 D-loop; other site 1246995001651 H-loop/switch region; other site 1246995001652 Helix-turn-helix domain; Region: HTH_18; pfam12833 1246995001653 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1246995001654 SnoaL-like domain; Region: SnoaL_2; pfam12680 1246995001655 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1246995001656 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 1246995001657 Domain of unknown function (DUF718); Region: DUF718; pfam05336 1246995001658 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 1246995001659 rhamnose ABC transporter, rhamnose-binding protein; Region: RhaS; TIGR02637 1246995001660 ligand binding site [chemical binding]; other site 1246995001661 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1246995001662 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1246995001663 TM-ABC transporter signature motif; other site 1246995001664 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1246995001665 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1246995001666 TM-ABC transporter signature motif; other site 1246995001667 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1246995001668 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1246995001669 Walker A/P-loop; other site 1246995001670 ATP binding site [chemical binding]; other site 1246995001671 Q-loop/lid; other site 1246995001672 ABC transporter signature motif; other site 1246995001673 Walker B; other site 1246995001674 D-loop; other site 1246995001675 H-loop/switch region; other site 1246995001676 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1246995001677 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1246995001678 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1246995001679 DNA binding site [nucleotide binding] 1246995001680 domain linker motif; other site 1246995001681 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1246995001682 ligand binding site [chemical binding]; other site 1246995001683 dimerization interface [polypeptide binding]; other site 1246995001684 short chain dehydrogenase; Validated; Region: PRK08324 1246995001685 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 1246995001686 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995001687 NAD(P) binding site [chemical binding]; other site 1246995001688 active site 1246995001689 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1246995001690 nucleotide binding site [chemical binding]; other site 1246995001691 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1246995001692 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1246995001693 Cysteine-rich domain; Region: CCG; pfam02754 1246995001694 Cysteine-rich domain; Region: CCG; pfam02754 1246995001695 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 1246995001696 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1246995001697 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 1246995001698 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 1246995001699 L-arabinose isomerase [Carbohydrate transport and metabolism]; Region: AraA; COG2160 1246995001700 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578 1246995001701 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1246995001702 substrate binding site [chemical binding]; other site 1246995001703 trimer interface [polypeptide binding]; other site 1246995001704 Mn binding site [ion binding]; other site 1246995001705 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995001706 NmrA-like family; Region: NmrA; pfam05368 1246995001707 NAD(P) binding site [chemical binding]; other site 1246995001708 active site 1246995001709 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 1246995001710 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1246995001711 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1246995001712 Ligand Binding Site [chemical binding]; other site 1246995001713 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1246995001714 dimer interface [polypeptide binding]; other site 1246995001715 phosphorylation site [posttranslational modification] 1246995001716 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995001717 ATP binding site [chemical binding]; other site 1246995001718 Mg2+ binding site [ion binding]; other site 1246995001719 G-X-G motif; other site 1246995001720 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995001721 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1246995001722 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1246995001723 Walker A/P-loop; other site 1246995001724 ATP binding site [chemical binding]; other site 1246995001725 Q-loop/lid; other site 1246995001726 ABC transporter signature motif; other site 1246995001727 Walker B; other site 1246995001728 D-loop; other site 1246995001729 H-loop/switch region; other site 1246995001730 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1246995001731 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 1246995001732 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1246995001733 Adenosylhomocysteinase; Provisional; Region: PTZ00075 1246995001734 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 1246995001735 homotetramer interface [polypeptide binding]; other site 1246995001736 ligand binding site [chemical binding]; other site 1246995001737 catalytic site [active] 1246995001738 NAD binding site [chemical binding]; other site 1246995001739 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 1246995001740 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1246995001741 DNA binding site [nucleotide binding] 1246995001742 domain linker motif; other site 1246995001743 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 1246995001744 putative ligand binding site [chemical binding]; other site 1246995001745 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1246995001746 YCII-related domain; Region: YCII; cl00999 1246995001747 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 1246995001748 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995001749 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1246995001750 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1246995001751 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1246995001752 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1246995001753 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1246995001754 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1246995001755 short chain dehydrogenase; Provisional; Region: PRK06198 1246995001756 classical (c) SDRs; Region: SDR_c; cd05233 1246995001757 NAD(P) binding site [chemical binding]; other site 1246995001758 active site 1246995001759 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1246995001760 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1246995001761 active site 1246995001762 catalytic residues [active] 1246995001763 metal binding site [ion binding]; metal-binding site 1246995001764 Methyltransferase domain; Region: Methyltransf_18; pfam12847 1246995001765 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1246995001766 Cytochrome P450; Region: p450; cl12078 1246995001767 pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14853 1246995001768 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1246995001769 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1246995001770 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 1246995001771 Walker A/P-loop; other site 1246995001772 ATP binding site [chemical binding]; other site 1246995001773 Q-loop/lid; other site 1246995001774 ABC transporter signature motif; other site 1246995001775 Walker B; other site 1246995001776 D-loop; other site 1246995001777 H-loop/switch region; other site 1246995001778 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1246995001779 Histidine kinase; Region: HisKA_3; pfam07730 1246995001780 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995001781 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995001782 active site 1246995001783 phosphorylation site [posttranslational modification] 1246995001784 intermolecular recognition site; other site 1246995001785 dimerization interface [polypeptide binding]; other site 1246995001786 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995001787 DNA binding residues [nucleotide binding] 1246995001788 dimerization interface [polypeptide binding]; other site 1246995001789 H+ Antiporter protein; Region: 2A0121; TIGR00900 1246995001790 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1246995001791 putative substrate translocation pore; other site 1246995001792 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1246995001793 putative DNA binding site [nucleotide binding]; other site 1246995001794 dimerization interface [polypeptide binding]; other site 1246995001795 putative Zn2+ binding site [ion binding]; other site 1246995001796 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1246995001797 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1246995001798 dimerization interface [polypeptide binding]; other site 1246995001799 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1246995001800 dimer interface [polypeptide binding]; other site 1246995001801 putative CheW interface [polypeptide binding]; other site 1246995001802 Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060 1246995001803 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1246995001804 HIGH motif; other site 1246995001805 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1246995001806 active site 1246995001807 KMSKS motif; other site 1246995001808 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 1246995001809 tRNA binding surface [nucleotide binding]; other site 1246995001810 anticodon binding site; other site 1246995001811 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 1246995001812 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 1246995001813 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1246995001814 MarR family; Region: MarR_2; pfam12802 1246995001815 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1246995001816 active site 1246995001817 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1246995001818 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1246995001819 metal binding site [ion binding]; metal-binding site 1246995001820 active site 1246995001821 I-site; other site 1246995001822 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1246995001823 Predicted flavoprotein [General function prediction only]; Region: COG0431 1246995001824 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1246995001825 MarR family; Region: MarR_2; pfam12802 1246995001826 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1246995001827 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1246995001828 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1246995001829 FAD binding domain; Region: FAD_binding_4; pfam01565 1246995001830 Berberine and berberine like; Region: BBE; pfam08031 1246995001831 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1246995001832 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1246995001833 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1246995001834 active site 1246995001835 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995001836 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995001837 DNA binding residues [nucleotide binding] 1246995001838 dimerization interface [polypeptide binding]; other site 1246995001839 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1246995001840 Quinone oxidoreductase (QOR); Region: quinone_oxidoreductase_like_1; cd08243 1246995001841 putative NAD(P) binding site [chemical binding]; other site 1246995001842 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 1246995001843 putative metal binding site [ion binding]; other site 1246995001844 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1246995001845 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 1246995001846 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 1246995001847 MOSC domain; Region: MOSC; pfam03473 1246995001848 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1246995001849 dimerization interface [polypeptide binding]; other site 1246995001850 putative DNA binding site [nucleotide binding]; other site 1246995001851 putative Zn2+ binding site [ion binding]; other site 1246995001852 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1246995001853 putative hydrophobic ligand binding site [chemical binding]; other site 1246995001854 RibD C-terminal domain; Region: RibD_C; cl17279 1246995001855 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1246995001856 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1246995001857 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1246995001858 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995001859 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995001860 short chain dehydrogenase; Provisional; Region: PRK12937 1246995001861 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 1246995001862 NADP binding site [chemical binding]; other site 1246995001863 homodimer interface [polypeptide binding]; other site 1246995001864 active site 1246995001865 substrate binding site [chemical binding]; other site 1246995001866 Domain of unknown function (DUF305); Region: DUF305; pfam03713 1246995001867 choice-of-anchor B domain; Region: choice_anch_B; TIGR04312 1246995001868 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1246995001869 S-adenosylmethionine binding site [chemical binding]; other site 1246995001870 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1246995001871 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1246995001872 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 1246995001873 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 1246995001874 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 1246995001875 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1246995001876 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 1246995001877 coproporphyrinogen III oxidase; Validated; Region: PRK08208 1246995001878 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1246995001879 FeS/SAM binding site; other site 1246995001880 HemN C-terminal domain; Region: HemN_C; pfam06969 1246995001881 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1246995001882 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1246995001883 FeS/SAM binding site; other site 1246995001884 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1246995001885 RNA polymerase factor sigma-70; Validated; Region: PRK08241 1246995001886 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995001887 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1246995001888 DNA binding residues [nucleotide binding] 1246995001889 SnoaL-like domain; Region: SnoaL_2; pfam12680 1246995001890 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 1246995001891 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1246995001892 putative active site [active] 1246995001893 putative NTP binding site [chemical binding]; other site 1246995001894 putative nucleic acid binding site [nucleotide binding]; other site 1246995001895 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 1246995001896 active site 1246995001897 Zn binding site [ion binding]; other site 1246995001898 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1246995001899 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1246995001900 Family description; Region: VCBS; pfam13517 1246995001901 Family description; Region: VCBS; pfam13517 1246995001902 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1246995001903 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1246995001904 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1246995001905 putative sugar binding sites [chemical binding]; other site 1246995001906 Q-X-W motif; other site 1246995001907 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1246995001908 putative sugar binding sites [chemical binding]; other site 1246995001909 Q-X-W motif; other site 1246995001910 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1246995001911 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1246995001912 protein-splicing catalytic site; other site 1246995001913 thioester formation/cholesterol transfer; other site 1246995001914 Pretoxin HINT domain; Region: PT-HINT; pfam07591 1246995001915 Family description; Region: VCBS; pfam13517 1246995001916 RHS Repeat; Region: RHS_repeat; cl11982 1246995001917 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1246995001918 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1246995001919 putative sugar binding sites [chemical binding]; other site 1246995001920 Q-X-W motif; other site 1246995001921 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1246995001922 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1246995001923 protein-splicing catalytic site; other site 1246995001924 thioester formation/cholesterol transfer; other site 1246995001925 Pretoxin HINT domain; Region: PT-HINT; pfam07591 1246995001926 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995001927 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995001928 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1246995001929 Cupin; Region: Cupin_6; pfam12852 1246995001930 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1246995001931 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1246995001932 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1246995001933 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995001934 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1246995001935 NAD(P) binding site [chemical binding]; other site 1246995001936 active site 1246995001937 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1246995001938 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1246995001939 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995001940 Q-loop/lid; other site 1246995001941 ABC transporter signature motif; other site 1246995001942 Walker B; other site 1246995001943 D-loop; other site 1246995001944 H-loop/switch region; other site 1246995001945 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1246995001946 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1246995001947 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995001948 Walker A/P-loop; other site 1246995001949 ATP binding site [chemical binding]; other site 1246995001950 Q-loop/lid; other site 1246995001951 ABC transporter signature motif; other site 1246995001952 Walker B; other site 1246995001953 D-loop; other site 1246995001954 H-loop/switch region; other site 1246995001955 HTH domain; Region: HTH_11; pfam08279 1246995001956 WYL domain; Region: WYL; pfam13280 1246995001957 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1246995001958 homotrimer interaction site [polypeptide binding]; other site 1246995001959 putative active site [active] 1246995001960 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995001961 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995001962 DNA binding residues [nucleotide binding] 1246995001963 dimerization interface [polypeptide binding]; other site 1246995001964 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 1246995001965 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1246995001966 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1246995001967 active site 1246995001968 catalytic residues [active] 1246995001969 DNA binding site [nucleotide binding] 1246995001970 Int/Topo IB signature motif; other site 1246995001971 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 1246995001972 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1246995001973 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436 1246995001974 putative dimerization interface [polypeptide binding]; other site 1246995001975 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 1246995001976 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995001977 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995001978 DNA binding residues [nucleotide binding] 1246995001979 dimerization interface [polypeptide binding]; other site 1246995001980 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995001981 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995001982 DNA binding residues [nucleotide binding] 1246995001983 dimerization interface [polypeptide binding]; other site 1246995001984 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1246995001985 anti sigma factor interaction site; other site 1246995001986 regulatory phosphorylation site [posttranslational modification]; other site 1246995001987 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1246995001988 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1246995001989 Mg2+ binding site [ion binding]; other site 1246995001990 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1246995001991 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1246995001992 Subunit A of Class III extradiol dioxygenases; Region: Extradiol_Dioxygenase_3A_like; cl06673 1246995001993 dimer interface [polypeptide binding]; other site 1246995001994 tetramer interface [polypeptide binding]; other site 1246995001995 Subunit B of the Class III Extradiol dioxygenase, Protocatechuate 4,5-dioxygenase, and simlar enzymes; Region: PCA_45_Doxase_B_like; cd07359 1246995001996 active site 1246995001997 Fe(II) binding site [ion binding]; other site 1246995001998 dimer interface [polypeptide binding]; other site 1246995001999 tetramer interface [polypeptide binding]; other site 1246995002000 Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100 1246995002001 active site 1246995002002 citrylCoA binding site [chemical binding]; other site 1246995002003 oxalacetate binding site [chemical binding]; other site 1246995002004 coenzyme A binding site [chemical binding]; other site 1246995002005 catalytic triad [active] 1246995002006 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1246995002007 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1246995002008 hypothetical protein; Provisional; Region: PRK08204 1246995002009 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1246995002010 active site 1246995002011 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 1246995002012 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1246995002013 Bacterial transcriptional regulator; Region: IclR; pfam01614 1246995002014 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1246995002015 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1246995002016 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1246995002017 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1246995002018 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1246995002019 S-adenosylmethionine binding site [chemical binding]; other site 1246995002020 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1246995002021 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1246995002022 active site 1246995002023 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1246995002024 DPG_synthase is involved in protein N-linked glycosylation; Region: DPG_synthase; cd04188 1246995002025 Putative Catalytic site; other site 1246995002026 DXD motif; other site 1246995002027 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1246995002028 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 1246995002029 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1246995002030 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1246995002031 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 1246995002032 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1246995002033 dimer interface [polypeptide binding]; other site 1246995002034 phosphorylation site [posttranslational modification] 1246995002035 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995002036 ATP binding site [chemical binding]; other site 1246995002037 Mg2+ binding site [ion binding]; other site 1246995002038 G-X-G motif; other site 1246995002039 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1246995002040 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995002041 active site 1246995002042 phosphorylation site [posttranslational modification] 1246995002043 intermolecular recognition site; other site 1246995002044 dimerization interface [polypeptide binding]; other site 1246995002045 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1246995002046 DNA binding site [nucleotide binding] 1246995002047 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1246995002048 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1246995002049 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1246995002050 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1246995002051 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1246995002052 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1246995002053 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1246995002054 Interdomain contacts; other site 1246995002055 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1246995002056 TPR motif; other site 1246995002057 TPR repeat; Region: TPR_11; pfam13414 1246995002058 binding surface 1246995002059 Smr domain; Region: Smr; pfam01713 1246995002060 M28 Zn-peptidase Endoplasmic reticulum metallopeptidase 1; Region: M28_Fxna_like; cd03875 1246995002061 Peptidase family M28; Region: Peptidase_M28; pfam04389 1246995002062 metal binding site [ion binding]; metal-binding site 1246995002063 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1246995002064 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995002065 active site 1246995002066 phosphorylation site [posttranslational modification] 1246995002067 intermolecular recognition site; other site 1246995002068 dimerization interface [polypeptide binding]; other site 1246995002069 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1246995002070 CHASE3 domain; Region: CHASE3; pfam05227 1246995002071 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1246995002072 dimerization interface [polypeptide binding]; other site 1246995002073 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1246995002074 dimer interface [polypeptide binding]; other site 1246995002075 phosphorylation site [posttranslational modification] 1246995002076 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995002077 ATP binding site [chemical binding]; other site 1246995002078 G-X-G motif; other site 1246995002079 Response regulator receiver domain; Region: Response_reg; pfam00072 1246995002080 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995002081 active site 1246995002082 phosphorylation site [posttranslational modification] 1246995002083 intermolecular recognition site; other site 1246995002084 dimerization interface [polypeptide binding]; other site 1246995002085 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1246995002086 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 1246995002087 active site 1246995002088 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 1246995002089 putative dimer interface [polypeptide binding]; other site 1246995002090 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1246995002091 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995002092 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1246995002093 NAD(P) binding site [chemical binding]; other site 1246995002094 active site 1246995002095 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1246995002096 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1246995002097 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1246995002098 active site 1246995002099 ATP binding site [chemical binding]; other site 1246995002100 substrate binding site [chemical binding]; other site 1246995002101 activation loop (A-loop); other site 1246995002102 Cellulose binding domain; Region: CBM_2; pfam00553 1246995002103 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1246995002104 TrkA-N domain; Region: TrkA_N; pfam02254 1246995002105 TrkA-C domain; Region: TrkA_C; pfam02080 1246995002106 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1246995002107 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1246995002108 H+ Antiporter protein; Region: 2A0121; TIGR00900 1246995002109 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1246995002110 S-adenosylmethionine binding site [chemical binding]; other site 1246995002111 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1246995002112 classical (c) SDRs; Region: SDR_c; cd05233 1246995002113 NAD(P) binding site [chemical binding]; other site 1246995002114 active site 1246995002115 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1246995002116 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1246995002117 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1246995002118 ATP binding site [chemical binding]; other site 1246995002119 putative Mg++ binding site [ion binding]; other site 1246995002120 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1246995002121 nucleotide binding region [chemical binding]; other site 1246995002122 ATP-binding site [chemical binding]; other site 1246995002123 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1246995002124 NlpC/P60 family; Region: NLPC_P60; pfam00877 1246995002125 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1246995002126 putative homodimer interface [polypeptide binding]; other site 1246995002127 putative homotetramer interface [polypeptide binding]; other site 1246995002128 putative allosteric switch controlling residues; other site 1246995002129 putative metal binding site [ion binding]; other site 1246995002130 putative homodimer-homodimer interface [polypeptide binding]; other site 1246995002131 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1246995002132 metal-binding site [ion binding] 1246995002133 Methyltransferase domain; Region: Methyltransf_32; pfam13679 1246995002134 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 1246995002135 heme binding pocket [chemical binding]; other site 1246995002136 heme ligand [chemical binding]; other site 1246995002137 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 1246995002138 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1246995002139 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1246995002140 ATP binding site [chemical binding]; other site 1246995002141 Mg++ binding site [ion binding]; other site 1246995002142 motif III; other site 1246995002143 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1246995002144 nucleotide binding region [chemical binding]; other site 1246995002145 ATP-binding site [chemical binding]; other site 1246995002146 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 1246995002147 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995002148 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995002149 large tegument protein UL36; Provisional; Region: PHA03247 1246995002150 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1246995002151 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1246995002152 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 1246995002153 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 1246995002154 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 1246995002155 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1246995002156 ATP binding site [chemical binding]; other site 1246995002157 substrate interface [chemical binding]; other site 1246995002158 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1246995002159 active site residue [active] 1246995002160 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 1246995002161 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 1246995002162 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1246995002163 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1246995002164 putative catalytic cysteine [active] 1246995002165 gamma-glutamyl kinase; Provisional; Region: PRK05429 1246995002166 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1246995002167 nucleotide binding site [chemical binding]; other site 1246995002168 homotetrameric interface [polypeptide binding]; other site 1246995002169 putative phosphate binding site [ion binding]; other site 1246995002170 putative allosteric binding site; other site 1246995002171 PUA domain; Region: PUA; pfam01472 1246995002172 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1246995002173 DNA binding site [nucleotide binding] 1246995002174 active site 1246995002175 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1246995002176 Leucine carboxyl methyltransferase; Region: LCM; cl01306 1246995002177 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995002178 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995002179 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995002180 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1246995002181 NAD(P) binding site [chemical binding]; other site 1246995002182 active site 1246995002183 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 1246995002184 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 1246995002185 MFS/sugar transport protein; Region: MFS_2; pfam13347 1246995002186 Phosphotransferase enzyme family; Region: APH; pfam01636 1246995002187 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1246995002188 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895 1246995002189 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 1246995002190 L-tyrosine decarboxylase; Provisional; Region: PRK13520 1246995002191 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1246995002192 catalytic residue [active] 1246995002193 NADH dehydrogenase subunit B; Validated; Region: PRK06411 1246995002194 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 1246995002195 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 1246995002196 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 1246995002197 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995002198 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1246995002199 DNA binding residues [nucleotide binding] 1246995002200 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 1246995002201 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1246995002202 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1246995002203 Beta-lactamase; Region: Beta-lactamase; pfam00144 1246995002204 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 1246995002205 4Fe-4S binding domain; Region: Fer4; pfam00037 1246995002206 NADH dehydrogenase subunit J; Provisional; Region: PRK06439 1246995002207 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1246995002208 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1246995002209 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1246995002210 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1246995002211 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1246995002212 heat shock protein HtpX; Provisional; Region: PRK03072 1246995002213 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1246995002214 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1246995002215 DNA-binding site [nucleotide binding]; DNA binding site 1246995002216 UTRA domain; Region: UTRA; pfam07702 1246995002217 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cd00413 1246995002218 active site 1246995002219 catalytic residues [active] 1246995002220 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1246995002221 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1246995002222 putative sugar binding sites [chemical binding]; other site 1246995002223 Q-X-W motif; other site 1246995002224 Peptidase family M23; Region: Peptidase_M23; pfam01551 1246995002225 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1246995002226 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1246995002227 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1246995002228 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1246995002229 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1246995002230 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1246995002231 MOSC domain; Region: MOSC; pfam03473 1246995002232 DDE superfamily endonuclease; Region: DDE_5; pfam13546 1246995002233 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 1246995002234 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995002235 YCII-related domain; Region: YCII; cl00999 1246995002236 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1246995002237 RibD C-terminal domain; Region: RibD_C; cl17279 1246995002238 Helix-turn-helix domain; Region: HTH_18; pfam12833 1246995002239 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1246995002240 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1246995002241 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1246995002242 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1246995002243 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1246995002244 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1246995002245 active site residue [active] 1246995002246 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1246995002247 active site residue [active] 1246995002248 GAF domain; Region: GAF; cl17456 1246995002249 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1246995002250 metal binding site [ion binding]; metal-binding site 1246995002251 active site 1246995002252 I-site; other site 1246995002253 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1246995002254 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 1246995002255 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1246995002256 active site 1246995002257 catalytic site [active] 1246995002258 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 1246995002259 active site 1246995002260 catalytic site [active] 1246995002261 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 1246995002262 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1246995002263 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1246995002264 putative homodimer interface [polypeptide binding]; other site 1246995002265 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1246995002266 heterodimer interface [polypeptide binding]; other site 1246995002267 homodimer interface [polypeptide binding]; other site 1246995002268 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1246995002269 mRNA/rRNA interface [nucleotide binding]; other site 1246995002270 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1246995002271 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995002272 Walker A/P-loop; other site 1246995002273 ATP binding site [chemical binding]; other site 1246995002274 Q-loop/lid; other site 1246995002275 ABC transporter signature motif; other site 1246995002276 Walker B; other site 1246995002277 D-loop; other site 1246995002278 H-loop/switch region; other site 1246995002279 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1246995002280 23S rRNA interface [nucleotide binding]; other site 1246995002281 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1246995002282 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1246995002283 L11 interface [polypeptide binding]; other site 1246995002284 putative EF-Tu interaction site [polypeptide binding]; other site 1246995002285 putative EF-G interaction site [polypeptide binding]; other site 1246995002286 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1246995002287 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1246995002288 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1246995002289 RPB1 interaction site [polypeptide binding]; other site 1246995002290 RPB10 interaction site [polypeptide binding]; other site 1246995002291 RPB11 interaction site [polypeptide binding]; other site 1246995002292 RPB3 interaction site [polypeptide binding]; other site 1246995002293 RPB12 interaction site [polypeptide binding]; other site 1246995002294 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1246995002295 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1246995002296 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1246995002297 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1246995002298 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 1246995002299 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1246995002300 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1246995002301 G-loop; other site 1246995002302 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1246995002303 DNA binding site [nucleotide binding] 1246995002304 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1246995002305 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1246995002306 S17 interaction site [polypeptide binding]; other site 1246995002307 S8 interaction site; other site 1246995002308 16S rRNA interaction site [nucleotide binding]; other site 1246995002309 streptomycin interaction site [chemical binding]; other site 1246995002310 23S rRNA interaction site [nucleotide binding]; other site 1246995002311 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1246995002312 30S ribosomal protein S7; Validated; Region: PRK05302 1246995002313 elongation factor G; Reviewed; Region: PRK00007 1246995002314 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1246995002315 G1 box; other site 1246995002316 putative GEF interaction site [polypeptide binding]; other site 1246995002317 GTP/Mg2+ binding site [chemical binding]; other site 1246995002318 Switch I region; other site 1246995002319 G2 box; other site 1246995002320 G3 box; other site 1246995002321 Switch II region; other site 1246995002322 G4 box; other site 1246995002323 G5 box; other site 1246995002324 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1246995002325 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1246995002326 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1246995002327 elongation factor Tu; Reviewed; Region: PRK00049 1246995002328 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1246995002329 G1 box; other site 1246995002330 GEF interaction site [polypeptide binding]; other site 1246995002331 GTP/Mg2+ binding site [chemical binding]; other site 1246995002332 Switch I region; other site 1246995002333 G2 box; other site 1246995002334 G3 box; other site 1246995002335 Switch II region; other site 1246995002336 G4 box; other site 1246995002337 G5 box; other site 1246995002338 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1246995002339 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1246995002340 Antibiotic Binding Site [chemical binding]; other site 1246995002341 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1246995002342 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1246995002343 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1246995002344 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1246995002345 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1246995002346 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1246995002347 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1246995002348 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1246995002349 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1246995002350 putative translocon binding site; other site 1246995002351 protein-rRNA interface [nucleotide binding]; other site 1246995002352 ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009 1246995002353 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1246995002354 G-X-X-G motif; other site 1246995002355 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1246995002356 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1246995002357 23S rRNA interface [nucleotide binding]; other site 1246995002358 5S rRNA interface [nucleotide binding]; other site 1246995002359 putative antibiotic binding site [chemical binding]; other site 1246995002360 L25 interface [polypeptide binding]; other site 1246995002361 L27 interface [polypeptide binding]; other site 1246995002362 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1246995002363 23S rRNA interface [nucleotide binding]; other site 1246995002364 putative translocon interaction site; other site 1246995002365 signal recognition particle (SRP54) interaction site; other site 1246995002366 L23 interface [polypeptide binding]; other site 1246995002367 trigger factor interaction site; other site 1246995002368 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1246995002369 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1246995002370 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1246995002371 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1246995002372 RNA binding site [nucleotide binding]; other site 1246995002373 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1246995002374 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1246995002375 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1246995002376 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1246995002377 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1246995002378 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1246995002379 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1246995002380 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1246995002381 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1246995002382 5S rRNA interface [nucleotide binding]; other site 1246995002383 L27 interface [polypeptide binding]; other site 1246995002384 23S rRNA interface [nucleotide binding]; other site 1246995002385 L5 interface [polypeptide binding]; other site 1246995002386 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1246995002387 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1246995002388 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1246995002389 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1246995002390 23S rRNA binding site [nucleotide binding]; other site 1246995002391 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1246995002392 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1246995002393 SecY translocase; Region: SecY; pfam00344 1246995002394 adenylate kinase; Reviewed; Region: adk; PRK00279 1246995002395 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1246995002396 AMP-binding site [chemical binding]; other site 1246995002397 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1246995002398 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1246995002399 active site 1246995002400 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1246995002401 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1246995002402 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1246995002403 rRNA binding site [nucleotide binding]; other site 1246995002404 predicted 30S ribosome binding site; other site 1246995002405 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 1246995002406 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1246995002407 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1246995002408 30S ribosomal protein S11; Validated; Region: PRK05309 1246995002409 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1246995002410 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1246995002411 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1246995002412 RNA binding surface [nucleotide binding]; other site 1246995002413 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1246995002414 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1246995002415 alphaNTD - beta interaction site [polypeptide binding]; other site 1246995002416 alphaNTD homodimer interface [polypeptide binding]; other site 1246995002417 alphaNTD - beta' interaction site [polypeptide binding]; other site 1246995002418 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1246995002419 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1246995002420 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1246995002421 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1246995002422 dimerization interface 3.5A [polypeptide binding]; other site 1246995002423 active site 1246995002424 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1246995002425 S-adenosylmethionine binding site [chemical binding]; other site 1246995002426 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1246995002427 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995002428 Walker A/P-loop; other site 1246995002429 ATP binding site [chemical binding]; other site 1246995002430 Q-loop/lid; other site 1246995002431 ABC transporter signature motif; other site 1246995002432 Walker B; other site 1246995002433 D-loop; other site 1246995002434 H-loop/switch region; other site 1246995002435 Eukaryotic initiation factor 1 and related proteins; Region: eIF1_SUI1_like; cl00229 1246995002436 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1246995002437 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1246995002438 thiamine phosphate binding site [chemical binding]; other site 1246995002439 active site 1246995002440 pyrophosphate binding site [ion binding]; other site 1246995002441 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1246995002442 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1246995002443 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1246995002444 thiS-thiF/thiG interaction site; other site 1246995002445 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1246995002446 ThiS interaction site; other site 1246995002447 putative active site [active] 1246995002448 tetramer interface [polypeptide binding]; other site 1246995002449 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1246995002450 thiamine phosphate binding site [chemical binding]; other site 1246995002451 active site 1246995002452 pyrophosphate binding site [ion binding]; other site 1246995002453 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1246995002454 dimer interface [polypeptide binding]; other site 1246995002455 substrate binding site [chemical binding]; other site 1246995002456 ATP binding site [chemical binding]; other site 1246995002457 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1246995002458 ThiC-associated domain; Region: ThiC-associated; pfam13667 1246995002459 ThiC family; Region: ThiC; pfam01964 1246995002460 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 1246995002461 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 1246995002462 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1246995002463 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1246995002464 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1246995002465 Walker A/P-loop; other site 1246995002466 ATP binding site [chemical binding]; other site 1246995002467 Q-loop/lid; other site 1246995002468 ABC transporter signature motif; other site 1246995002469 Walker B; other site 1246995002470 D-loop; other site 1246995002471 H-loop/switch region; other site 1246995002472 NMT1/THI5 like; Region: NMT1; pfam09084 1246995002473 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1246995002474 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1246995002475 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995002476 dimer interface [polypeptide binding]; other site 1246995002477 conserved gate region; other site 1246995002478 putative PBP binding loops; other site 1246995002479 ABC-ATPase subunit interface; other site 1246995002480 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1246995002481 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1246995002482 Nitrate and nitrite sensing; Region: NIT; pfam08376 1246995002483 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1246995002484 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995002485 ATP binding site [chemical binding]; other site 1246995002486 Mg2+ binding site [ion binding]; other site 1246995002487 G-X-G motif; other site 1246995002488 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 1246995002489 Protein of unknown function (DUF742); Region: DUF742; pfam05331 1246995002490 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1246995002491 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 1246995002492 G1 box; other site 1246995002493 GTP/Mg2+ binding site [chemical binding]; other site 1246995002494 G2 box; other site 1246995002495 Switch I region; other site 1246995002496 G3 box; other site 1246995002497 Switch II region; other site 1246995002498 G4 box; other site 1246995002499 G5 box; other site 1246995002500 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 1246995002501 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1246995002502 active site 1246995002503 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1246995002504 DNA binding site [nucleotide binding] 1246995002505 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1246995002506 23S rRNA interface [nucleotide binding]; other site 1246995002507 L3 interface [polypeptide binding]; other site 1246995002508 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1246995002509 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 1246995002510 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1246995002511 active site 1246995002512 substrate binding site [chemical binding]; other site 1246995002513 metal binding site [ion binding]; metal-binding site 1246995002514 aminotransferase; Validated; Region: PRK07777 1246995002515 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1246995002516 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1246995002517 homodimer interface [polypeptide binding]; other site 1246995002518 catalytic residue [active] 1246995002519 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1246995002520 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1246995002521 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1246995002522 glutaminase active site [active] 1246995002523 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1246995002524 dimer interface [polypeptide binding]; other site 1246995002525 active site 1246995002526 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1246995002527 dimer interface [polypeptide binding]; other site 1246995002528 active site 1246995002529 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 1246995002530 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1246995002531 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 1246995002532 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1246995002533 putative substrate binding site [chemical binding]; other site 1246995002534 putative ATP binding site [chemical binding]; other site 1246995002535 alanine racemase; Reviewed; Region: alr; PRK00053 1246995002536 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1246995002537 active site 1246995002538 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1246995002539 dimer interface [polypeptide binding]; other site 1246995002540 substrate binding site [chemical binding]; other site 1246995002541 catalytic residues [active] 1246995002542 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1246995002543 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1246995002544 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 1246995002545 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1246995002546 ligand binding site [chemical binding]; other site 1246995002547 active site 1246995002548 UGI interface [polypeptide binding]; other site 1246995002549 catalytic site [active] 1246995002550 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1246995002551 Glycoprotease family; Region: Peptidase_M22; pfam00814 1246995002552 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1246995002553 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1246995002554 Coenzyme A binding pocket [chemical binding]; other site 1246995002555 UGMP family protein; Validated; Region: PRK09604 1246995002556 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1246995002557 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1246995002558 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1246995002559 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995002560 Q-loop/lid; other site 1246995002561 ABC transporter signature motif; other site 1246995002562 Walker B; other site 1246995002563 D-loop; other site 1246995002564 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1246995002565 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1246995002566 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995002567 Walker A/P-loop; other site 1246995002568 ATP binding site [chemical binding]; other site 1246995002569 Q-loop/lid; other site 1246995002570 ABC transporter signature motif; other site 1246995002571 Walker B; other site 1246995002572 D-loop; other site 1246995002573 H-loop/switch region; other site 1246995002574 MarR family; Region: MarR_2; pfam12802 1246995002575 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1246995002576 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1246995002577 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1246995002578 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1246995002579 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1246995002580 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1246995002581 TM-ABC transporter signature motif; other site 1246995002582 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1246995002583 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1246995002584 Walker A/P-loop; other site 1246995002585 ATP binding site [chemical binding]; other site 1246995002586 Q-loop/lid; other site 1246995002587 ABC transporter signature motif; other site 1246995002588 Walker B; other site 1246995002589 D-loop; other site 1246995002590 H-loop/switch region; other site 1246995002591 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 1246995002592 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 1246995002593 putative ligand binding site [chemical binding]; other site 1246995002594 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1246995002595 putative deacylase active site [active] 1246995002596 Methyltransferase domain; Region: Methyltransf_18; pfam12847 1246995002597 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1246995002598 oligomerisation interface [polypeptide binding]; other site 1246995002599 mobile loop; other site 1246995002600 roof hairpin; other site 1246995002601 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1246995002602 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1246995002603 ring oligomerisation interface [polypeptide binding]; other site 1246995002604 ATP/Mg binding site [chemical binding]; other site 1246995002605 stacking interactions; other site 1246995002606 hinge regions; other site 1246995002607 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1246995002608 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 1246995002609 Moco binding site; other site 1246995002610 metal coordination site [ion binding]; other site 1246995002611 dimerization interface [polypeptide binding]; other site 1246995002612 Transcription factor WhiB; Region: Whib; pfam02467 1246995002613 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995002614 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995002615 DNA binding residues [nucleotide binding] 1246995002616 dimerization interface [polypeptide binding]; other site 1246995002617 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1246995002618 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1246995002619 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1246995002620 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1246995002621 active site 1246995002622 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 1246995002623 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1246995002624 phosphate binding site [ion binding]; other site 1246995002625 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 1246995002626 Zn binding site [ion binding]; other site 1246995002627 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1246995002628 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1246995002629 active site 1246995002630 catalytic residues [active] 1246995002631 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 1246995002632 active site 1246995002633 catalytic triad [active] 1246995002634 GMP synthase; Reviewed; Region: guaA; PRK00074 1246995002635 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1246995002636 AMP/PPi binding site [chemical binding]; other site 1246995002637 candidate oxyanion hole; other site 1246995002638 catalytic triad [active] 1246995002639 potential glutamine specificity residues [chemical binding]; other site 1246995002640 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1246995002641 ATP Binding subdomain [chemical binding]; other site 1246995002642 Ligand Binding sites [chemical binding]; other site 1246995002643 Dimerization subdomain; other site 1246995002644 PspC domain; Region: PspC; pfam04024 1246995002645 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1246995002646 nudix motif; other site 1246995002647 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 1246995002648 nudix motif; other site 1246995002649 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1246995002650 nudix motif; other site 1246995002651 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1246995002652 nudix motif; other site 1246995002653 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1246995002654 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 1246995002655 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 1246995002656 PspC domain; Region: PspC; pfam04024 1246995002657 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1246995002658 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995002659 ATP binding site [chemical binding]; other site 1246995002660 G-X-G motif; other site 1246995002661 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995002662 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995002663 active site 1246995002664 phosphorylation site [posttranslational modification] 1246995002665 intermolecular recognition site; other site 1246995002666 dimerization interface [polypeptide binding]; other site 1246995002667 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995002668 DNA binding residues [nucleotide binding] 1246995002669 dimerization interface [polypeptide binding]; other site 1246995002670 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1246995002671 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1246995002672 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1246995002673 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1246995002674 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995002675 ABC-ATPase subunit interface; other site 1246995002676 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1246995002677 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1246995002678 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995002679 dimer interface [polypeptide binding]; other site 1246995002680 conserved gate region; other site 1246995002681 putative PBP binding loops; other site 1246995002682 ABC-ATPase subunit interface; other site 1246995002683 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1246995002684 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1246995002685 Walker A/P-loop; other site 1246995002686 ATP binding site [chemical binding]; other site 1246995002687 Q-loop/lid; other site 1246995002688 ABC transporter signature motif; other site 1246995002689 Walker B; other site 1246995002690 D-loop; other site 1246995002691 H-loop/switch region; other site 1246995002692 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1246995002693 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 1246995002694 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1246995002695 Walker A/P-loop; other site 1246995002696 ATP binding site [chemical binding]; other site 1246995002697 Q-loop/lid; other site 1246995002698 ABC transporter signature motif; other site 1246995002699 Walker B; other site 1246995002700 D-loop; other site 1246995002701 H-loop/switch region; other site 1246995002702 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1246995002703 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1246995002704 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1246995002705 Chorismate mutase type II; Region: CM_2; cl00693 1246995002706 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1246995002707 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 1246995002708 putative active site [active] 1246995002709 putative metal binding site [ion binding]; other site 1246995002710 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1246995002711 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1246995002712 Part of AAA domain; Region: AAA_19; pfam13245 1246995002713 Family description; Region: UvrD_C_2; pfam13538 1246995002714 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1246995002715 Peptidase family M23; Region: Peptidase_M23; pfam01551 1246995002716 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1246995002717 Peptidase family M23; Region: Peptidase_M23; pfam01551 1246995002718 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 1246995002719 B12 binding site [chemical binding]; other site 1246995002720 cobalt ligand [ion binding]; other site 1246995002721 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1246995002722 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1246995002723 CoA-ligase; Region: Ligase_CoA; pfam00549 1246995002724 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1246995002725 CoA binding domain; Region: CoA_binding; smart00881 1246995002726 CoA-ligase; Region: Ligase_CoA; pfam00549 1246995002727 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1246995002728 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1246995002729 active site 1246995002730 substrate binding site [chemical binding]; other site 1246995002731 cosubstrate binding site; other site 1246995002732 catalytic site [active] 1246995002733 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1246995002734 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1246995002735 purine monophosphate binding site [chemical binding]; other site 1246995002736 dimer interface [polypeptide binding]; other site 1246995002737 putative catalytic residues [active] 1246995002738 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1246995002739 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1246995002740 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1246995002741 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1246995002742 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1246995002743 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1246995002744 malate dehydrogenase; Reviewed; Region: PRK06223 1246995002745 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 1246995002746 NAD(P) binding site [chemical binding]; other site 1246995002747 dimer interface [polypeptide binding]; other site 1246995002748 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1246995002749 substrate binding site [chemical binding]; other site 1246995002750 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1246995002751 PhoD-like phosphatase; Region: PhoD; pfam09423 1246995002752 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1246995002753 putative active site [active] 1246995002754 putative metal binding site [ion binding]; other site 1246995002755 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1246995002756 isocitrate dehydrogenase; Validated; Region: PRK08299 1246995002757 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 1246995002758 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 1246995002759 dimer interface [polypeptide binding]; other site 1246995002760 active site 1246995002761 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1246995002762 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1246995002763 DNA-binding site [nucleotide binding]; DNA binding site 1246995002764 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1246995002765 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1246995002766 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1246995002767 active site 1246995002768 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1246995002769 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1246995002770 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 1246995002771 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1246995002772 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1246995002773 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1246995002774 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1246995002775 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 1246995002776 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 1246995002777 Chain length determinant protein; Region: Wzz; cl15801 1246995002778 Chain length determinant protein; Region: Wzz; cl15801 1246995002779 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1246995002780 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Validated; Region: PRK05537 1246995002781 PUA-like domain; Region: PUA_2; pfam14306 1246995002782 ATP-sulfurylase; Region: ATP-sulfurylase; pfam01747 1246995002783 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1246995002784 ligand-binding site [chemical binding]; other site 1246995002785 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 1246995002786 gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522 1246995002787 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1246995002788 Walker A/P-loop; other site 1246995002789 ATP binding site [chemical binding]; other site 1246995002790 Q-loop/lid; other site 1246995002791 ABC transporter signature motif; other site 1246995002792 Walker B; other site 1246995002793 D-loop; other site 1246995002794 H-loop/switch region; other site 1246995002795 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1246995002796 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1246995002797 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1246995002798 Walker A/P-loop; other site 1246995002799 ATP binding site [chemical binding]; other site 1246995002800 Q-loop/lid; other site 1246995002801 ABC transporter signature motif; other site 1246995002802 Walker B; other site 1246995002803 D-loop; other site 1246995002804 H-loop/switch region; other site 1246995002805 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 1246995002806 AAA domain; Region: AAA_21; pfam13304 1246995002807 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 1246995002808 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1246995002809 DNA binding residues [nucleotide binding] 1246995002810 putative dimer interface [polypeptide binding]; other site 1246995002811 short chain dehydrogenase; Validated; Region: PRK08264 1246995002812 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995002813 NAD(P) binding site [chemical binding]; other site 1246995002814 active site 1246995002815 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 1246995002816 Phosphoenolpyruvate carboxylase; Region: PEPcase; pfam00311 1246995002817 Lysyl oxidase; Region: Lysyl_oxidase; pfam01186 1246995002818 Bulb-type mannose-specific lectin; Region: B_lectin; smart00108 1246995002819 Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028 1246995002820 mannose binding site [chemical binding]; other site 1246995002821 dimerization interface [polypeptide binding]; other site 1246995002822 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 1246995002823 Glyoxal oxidase N-terminus; Region: Glyoxal_oxid_N; pfam07250 1246995002824 C-terminal Early set domain associated with the catalytic domain of galactose oxidase; Region: E_set_GO_C; cd02851 1246995002825 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1246995002826 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 1246995002827 DXD motif; other site 1246995002828 Cellulose synthase-like protein; Region: PLN02893 1246995002829 HypX protein, N-terminal hydrolase domain; Region: FMT_core_HypX_N; cd08650 1246995002830 putative active site [active] 1246995002831 putative substrate binding site [chemical binding]; other site 1246995002832 putative cosubstrate binding site; other site 1246995002833 catalytic site [active] 1246995002834 C-terminal subdomain of the Formyltransferase-like domain found in HypX-like proteins; Region: FMT_C_HypX; cd08701 1246995002835 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1246995002836 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1246995002837 substrate binding site [chemical binding]; other site 1246995002838 oxyanion hole (OAH) forming residues; other site 1246995002839 trimer interface [polypeptide binding]; other site 1246995002840 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1246995002841 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1246995002842 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1246995002843 ATP binding site [chemical binding]; other site 1246995002844 putative Mg++ binding site [ion binding]; other site 1246995002845 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1246995002846 nucleotide binding region [chemical binding]; other site 1246995002847 ATP-binding site [chemical binding]; other site 1246995002848 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1246995002849 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 1246995002850 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1246995002851 homodimer interface [polypeptide binding]; other site 1246995002852 metal binding site [ion binding]; metal-binding site 1246995002853 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 1246995002854 Fic family protein [Function unknown]; Region: COG3177 1246995002855 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 1246995002856 Fic/DOC family; Region: Fic; pfam02661 1246995002857 enolase; Provisional; Region: eno; PRK00077 1246995002858 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1246995002859 dimer interface [polypeptide binding]; other site 1246995002860 metal binding site [ion binding]; metal-binding site 1246995002861 substrate binding pocket [chemical binding]; other site 1246995002862 Septum formation initiator; Region: DivIC; pfam04977 1246995002863 Protein of unknown function (DUF501); Region: DUF501; cl00652 1246995002864 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1246995002865 Coenzyme A binding pocket [chemical binding]; other site 1246995002866 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1246995002867 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1246995002868 Predicted transcriptional regulators [Transcription]; Region: COG1695 1246995002869 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1246995002870 Predicted membrane protein [Function unknown]; Region: COG4709 1246995002871 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 1246995002872 Fe-S cluster binding site [ion binding]; other site 1246995002873 DNA binding site [nucleotide binding] 1246995002874 active site 1246995002875 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1246995002876 MoxR-like ATPases [General function prediction only]; Region: COG0714 1246995002877 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1246995002878 Walker A motif; other site 1246995002879 ATP binding site [chemical binding]; other site 1246995002880 Walker B motif; other site 1246995002881 arginine finger; other site 1246995002882 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1246995002883 Protein of unknown function DUF58; Region: DUF58; pfam01882 1246995002884 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1246995002885 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1246995002886 Bax inhibitor 1 like; Region: BaxI_1; cl17691 1246995002887 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1246995002888 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 1246995002889 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1246995002890 dimer interface [polypeptide binding]; other site 1246995002891 active site 1246995002892 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 1246995002893 active site 1246995002894 catalytic triad [active] 1246995002895 oxyanion hole [active] 1246995002896 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 1246995002897 active site 1246995002898 catalytic triad [active] 1246995002899 oxyanion hole [active] 1246995002900 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 1246995002901 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 1246995002902 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1246995002903 dimer interface [polypeptide binding]; other site 1246995002904 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1246995002905 catalytic residue [active] 1246995002906 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 1246995002907 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1246995002908 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1246995002909 metal binding site [ion binding]; metal-binding site 1246995002910 active site 1246995002911 I-site; other site 1246995002912 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 1246995002913 putative active site; other site 1246995002914 putative metal binding residues [ion binding]; other site 1246995002915 signature motif; other site 1246995002916 putative triphosphate binding site [ion binding]; other site 1246995002917 CHAD domain; Region: CHAD; pfam05235 1246995002918 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 1246995002919 ribonuclease Z; Reviewed; Region: PRK00055 1246995002920 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1246995002921 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1246995002922 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1246995002923 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1246995002924 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 1246995002925 methionine sulfoxide reductase A; Provisional; Region: PRK00058 1246995002926 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1246995002927 nucleotide binding site/active site [active] 1246995002928 HIT family signature motif; other site 1246995002929 catalytic residue [active] 1246995002930 cystathionine gamma-synthase; Provisional; Region: PRK07811 1246995002931 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1246995002932 homodimer interface [polypeptide binding]; other site 1246995002933 substrate-cofactor binding pocket; other site 1246995002934 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1246995002935 catalytic residue [active] 1246995002936 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1246995002937 Amidase; Region: Amidase; cl11426 1246995002938 threonine dehydratase; Provisional; Region: PRK08198 1246995002939 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1246995002940 tetramer interface [polypeptide binding]; other site 1246995002941 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1246995002942 catalytic residue [active] 1246995002943 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 1246995002944 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1246995002945 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1246995002946 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1246995002947 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 1246995002948 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 1246995002949 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1246995002950 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1246995002951 metal binding site [ion binding]; metal-binding site 1246995002952 active site 1246995002953 I-site; other site 1246995002954 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1246995002955 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 1246995002956 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 1246995002957 catalytic residues [active] 1246995002958 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 1246995002959 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 1246995002960 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1246995002961 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995002962 NAD(P) binding site [chemical binding]; other site 1246995002963 active site 1246995002964 ATP-grasp domain; Region: ATP-grasp; pfam02222 1246995002965 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1246995002966 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1246995002967 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1246995002968 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1246995002969 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1246995002970 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1246995002971 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1246995002972 active site 1246995002973 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1246995002974 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1246995002975 active site 1246995002976 ATP binding site [chemical binding]; other site 1246995002977 substrate binding site [chemical binding]; other site 1246995002978 activation loop (A-loop); other site 1246995002979 hypothetical protein; Provisional; Region: PRK07236 1246995002980 hypothetical protein; Provisional; Region: PRK07588 1246995002981 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1246995002982 MarR family; Region: MarR_2; pfam12802 1246995002983 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1246995002984 salt bridge; other site 1246995002985 non-specific DNA binding site [nucleotide binding]; other site 1246995002986 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1246995002987 sequence-specific DNA binding site [nucleotide binding]; other site 1246995002988 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1246995002989 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 1246995002990 Nucleosome binding factor SPN, SPT16 subunit [Transcription / DNA replication, recombination, and repair / Chromatin structure and dynamics]; Region: COG5406 1246995002991 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1246995002992 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 1246995002993 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1246995002994 acyl-activating enzyme (AAE) consensus motif; other site 1246995002995 AMP binding site [chemical binding]; other site 1246995002996 active site 1246995002997 CoA binding site [chemical binding]; other site 1246995002998 TIGR03089 family protein; Region: TIGR03089 1246995002999 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1246995003000 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1246995003001 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 1246995003002 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1246995003003 Substrate binding site; other site 1246995003004 Cupin domain; Region: Cupin_2; cl17218 1246995003005 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 1246995003006 nudix motif; other site 1246995003007 GTP and metal dependent enzyme involved F420 coenzyme biosynthesis (catalyzes addition of two l-glutamates to F420 precursor) [Coenzyme transport and metabolism]; Region: COG1478 1246995003008 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996 1246995003009 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 1246995003010 LPPG:FO 2-phospho-L-lactate transferase; important in F420 biosynthesis; Region: CofD_like; cd07186 1246995003011 phosphate binding site [ion binding]; other site 1246995003012 dimer interface [polypeptide binding]; other site 1246995003013 substrate binding site [chemical binding]; other site 1246995003014 FO synthase; Reviewed; Region: fbiC; PRK09234 1246995003015 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1246995003016 FeS/SAM binding site; other site 1246995003017 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1246995003018 FeS/SAM binding site; other site 1246995003019 Transcription factor WhiB; Region: Whib; pfam02467 1246995003020 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 1246995003021 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 1246995003022 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1246995003023 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1246995003024 NodB motif; other site 1246995003025 active site 1246995003026 catalytic site [active] 1246995003027 metal binding site [ion binding]; metal-binding site 1246995003028 Protein of unknown function (DUF3455); Region: DUF3455; pfam11937 1246995003029 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1246995003030 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1246995003031 NAD(P) binding site [chemical binding]; other site 1246995003032 catalytic residues [active] 1246995003033 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1246995003034 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1246995003035 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1246995003036 NAD(P) binding site [chemical binding]; other site 1246995003037 catalytic residues [active] 1246995003038 Protein of unknown function (DUF779); Region: DUF779; pfam05610 1246995003039 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 1246995003040 Active_site [active] 1246995003041 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 1246995003042 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1246995003043 active site 1246995003044 substrate binding site [chemical binding]; other site 1246995003045 metal binding site [ion binding]; metal-binding site 1246995003046 Uncharacterized conserved protein [Function unknown]; Region: COG2835 1246995003047 bifunctional phosphoglucose/phosphomannose isomerase; Validated; Region: PRK08674 1246995003048 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1246995003049 The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_2; cd05637 1246995003050 dimer interface [polypeptide binding]; other site 1246995003051 active site 1246995003052 Cation efflux family; Region: Cation_efflux; pfam01545 1246995003053 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1246995003054 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 1246995003055 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1246995003056 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1246995003057 sequence-specific DNA binding site [nucleotide binding]; other site 1246995003058 salt bridge; other site 1246995003059 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1246995003060 Iron permease FTR1 family; Region: FTR1; cl00475 1246995003061 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 1246995003062 Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822 1246995003063 Imelysin; Region: Peptidase_M75; pfam09375 1246995003064 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 1246995003065 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1246995003066 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995003067 active site 1246995003068 phosphorylation site [posttranslational modification] 1246995003069 intermolecular recognition site; other site 1246995003070 dimerization interface [polypeptide binding]; other site 1246995003071 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1246995003072 DNA binding site [nucleotide binding] 1246995003073 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1246995003074 dimerization interface [polypeptide binding]; other site 1246995003075 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1246995003076 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1246995003077 dimer interface [polypeptide binding]; other site 1246995003078 phosphorylation site [posttranslational modification] 1246995003079 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995003080 ATP binding site [chemical binding]; other site 1246995003081 Mg2+ binding site [ion binding]; other site 1246995003082 G-X-G motif; other site 1246995003083 lipoprotein LpqB; Provisional; Region: PRK13616 1246995003084 Sporulation and spore germination; Region: Germane; pfam10646 1246995003085 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1246995003086 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1246995003087 30S subunit binding site; other site 1246995003088 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1246995003089 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1246995003090 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1246995003091 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1246995003092 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1246995003093 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1246995003094 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1246995003095 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1246995003096 Coenzyme A binding pocket [chemical binding]; other site 1246995003097 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1246995003098 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1246995003099 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1246995003100 nucleotide binding region [chemical binding]; other site 1246995003101 SEC-C motif; Region: SEC-C; pfam02810 1246995003102 Helix-turn-helix domain; Region: HTH_17; pfam12728 1246995003103 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1246995003104 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1246995003105 putative DNA binding site [nucleotide binding]; other site 1246995003106 putative Zn2+ binding site [ion binding]; other site 1246995003107 AsnC family; Region: AsnC_trans_reg; pfam01037 1246995003108 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1246995003109 active site residue [active] 1246995003110 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1246995003111 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 1246995003112 NAD(P) binding site [chemical binding]; other site 1246995003113 catalytic residues [active] 1246995003114 peptide chain release factor 2; Validated; Region: prfB; PRK00578 1246995003115 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1246995003116 RF-1 domain; Region: RF-1; pfam00472 1246995003117 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1246995003118 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995003119 Walker A/P-loop; other site 1246995003120 ATP binding site [chemical binding]; other site 1246995003121 Q-loop/lid; other site 1246995003122 ABC transporter signature motif; other site 1246995003123 Walker B; other site 1246995003124 D-loop; other site 1246995003125 H-loop/switch region; other site 1246995003126 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1246995003127 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1246995003128 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1246995003129 Peptidase family M23; Region: Peptidase_M23; pfam01551 1246995003130 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1246995003131 SmpB-tmRNA interface; other site 1246995003132 Cellulose binding domain; Region: CBM_2; cl17741 1246995003133 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1246995003134 active site 1246995003135 metal binding site [ion binding]; metal-binding site 1246995003136 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995003137 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995003138 DNA binding residues [nucleotide binding] 1246995003139 dimerization interface [polypeptide binding]; other site 1246995003140 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1246995003141 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1246995003142 catalytic residue [active] 1246995003143 5'-methylthioadenosine phosphorylase; Validated; Region: PRK07823 1246995003144 hypothetical protein; Validated; Region: PRK00228 1246995003145 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1246995003146 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1246995003147 Predicted ATPase [General function prediction only]; Region: COG3903 1246995003148 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1246995003149 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1246995003150 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1246995003151 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1246995003152 DNA-binding site [nucleotide binding]; DNA binding site 1246995003153 FCD domain; Region: FCD; pfam07729 1246995003154 PQQ-like domain; Region: PQQ_2; pfam13360 1246995003155 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1246995003156 Trp docking motif [polypeptide binding]; other site 1246995003157 active site 1246995003158 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1246995003159 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1246995003160 DNA binding residues [nucleotide binding] 1246995003161 dimer interface [polypeptide binding]; other site 1246995003162 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 1246995003163 type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523 1246995003164 Competence protein A; Region: Competence_A; pfam11104 1246995003165 Cell division protein FtsA; Region: FtsA; cl17206 1246995003166 Cell division protein FtsA; Region: FtsA; pfam14450 1246995003167 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1246995003168 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1246995003169 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1246995003170 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1246995003171 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1246995003172 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 1246995003173 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1246995003174 Walker A motif; other site 1246995003175 ATP binding site [chemical binding]; other site 1246995003176 Walker B motif; other site 1246995003177 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 1246995003178 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1246995003179 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1246995003180 Walker A motif; other site 1246995003181 ATP binding site [chemical binding]; other site 1246995003182 Walker B motif; other site 1246995003183 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 1246995003184 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1246995003185 conserved cys residue [active] 1246995003186 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1246995003187 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1246995003188 putative substrate translocation pore; other site 1246995003189 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1246995003190 Streptomyces extracellular neutral proteinase (M7) family; Region: Peptidase_M7; pfam02031 1246995003191 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1246995003192 anti sigma factor interaction site; other site 1246995003193 regulatory phosphorylation site [posttranslational modification]; other site 1246995003194 NB-ARC domain; Region: NB-ARC; pfam00931 1246995003195 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1246995003196 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1246995003197 Tetratricopeptide repeat; Region: TPR_10; pfam13374 1246995003198 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1246995003199 Tetratricopeptide repeat; Region: TPR_10; pfam13374 1246995003200 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1246995003201 Tetratricopeptide repeat; Region: TPR_10; pfam13374 1246995003202 Response regulator receiver domain; Region: Response_reg; pfam00072 1246995003203 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995003204 active site 1246995003205 phosphorylation site [posttranslational modification] 1246995003206 intermolecular recognition site; other site 1246995003207 dimerization interface [polypeptide binding]; other site 1246995003208 GAF domain; Region: GAF_3; pfam13492 1246995003209 GAF domain; Region: GAF_2; pfam13185 1246995003210 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1246995003211 putative active site [active] 1246995003212 heme pocket [chemical binding]; other site 1246995003213 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1246995003214 GAF domain; Region: GAF; pfam01590 1246995003215 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1246995003216 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1246995003217 dimer interface [polypeptide binding]; other site 1246995003218 phosphorylation site [posttranslational modification] 1246995003219 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995003220 ATP binding site [chemical binding]; other site 1246995003221 Mg2+ binding site [ion binding]; other site 1246995003222 G-X-G motif; other site 1246995003223 Response regulator receiver domain; Region: Response_reg; pfam00072 1246995003224 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995003225 active site 1246995003226 phosphorylation site [posttranslational modification] 1246995003227 intermolecular recognition site; other site 1246995003228 dimerization interface [polypeptide binding]; other site 1246995003229 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1246995003230 MarR family; Region: MarR_2; pfam12802 1246995003231 classical (c) SDRs; Region: SDR_c; cd05233 1246995003232 NAD(P) binding site [chemical binding]; other site 1246995003233 active site 1246995003234 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1246995003235 metal binding site [ion binding]; metal-binding site 1246995003236 active site 1246995003237 I-site; other site 1246995003238 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1246995003239 HEXXH motif domain; Region: mod_HExxH; TIGR04267 1246995003240 Domain of unknown function (DUF427); Region: DUF427; pfam04248 1246995003241 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1246995003242 GAF domain; Region: GAF; pfam01590 1246995003243 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1246995003244 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1246995003245 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1246995003246 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1246995003247 hydrophobic ligand binding site; other site 1246995003248 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 1246995003249 polymerase nucleotide-binding site; other site 1246995003250 DNA-binding residues [nucleotide binding]; DNA binding site 1246995003251 nucleotide binding site [chemical binding]; other site 1246995003252 primase nucleotide-binding site [nucleotide binding]; other site 1246995003253 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1246995003254 Beta protein; Region: Beta_protein; pfam14350 1246995003255 Part of AAA domain; Region: AAA_19; pfam13245 1246995003256 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 1246995003257 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1246995003258 active site 1246995003259 catalytic residues [active] 1246995003260 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 1246995003261 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995003262 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995003263 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1246995003264 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995003265 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1246995003266 Walker A/P-loop; other site 1246995003267 ATP binding site [chemical binding]; other site 1246995003268 Q-loop/lid; other site 1246995003269 ABC transporter signature motif; other site 1246995003270 Walker B; other site 1246995003271 D-loop; other site 1246995003272 H-loop/switch region; other site 1246995003273 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1246995003274 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1246995003275 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1246995003276 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1246995003277 DNA-binding site [nucleotide binding]; DNA binding site 1246995003278 FCD domain; Region: FCD; pfam07729 1246995003279 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 1246995003280 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1246995003281 Na binding site [ion binding]; other site 1246995003282 putative substrate binding site [chemical binding]; other site 1246995003283 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 1246995003284 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 1246995003285 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 1246995003286 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1246995003287 catalytic residue [active] 1246995003288 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1246995003289 classical (c) SDRs; Region: SDR_c; cd05233 1246995003290 NAD(P) binding site [chemical binding]; other site 1246995003291 active site 1246995003292 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1246995003293 Walker A motif; other site 1246995003294 ATP binding site [chemical binding]; other site 1246995003295 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 1246995003296 AAA domain; Region: AAA_12; pfam13087 1246995003297 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1246995003298 putative active site [active] 1246995003299 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1246995003300 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 1246995003301 conserved cys residue [active] 1246995003302 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1246995003303 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 1246995003304 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1246995003305 PAS fold; Region: PAS_3; pfam08447 1246995003306 putative active site [active] 1246995003307 heme pocket [chemical binding]; other site 1246995003308 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1246995003309 metal binding site [ion binding]; metal-binding site 1246995003310 active site 1246995003311 I-site; other site 1246995003312 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1246995003313 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 1246995003314 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1246995003315 MarR family; Region: MarR_2; cl17246 1246995003316 Repair protein; Region: Repair_PSII; cl01535 1246995003317 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 1246995003318 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1246995003319 NAD binding site [chemical binding]; other site 1246995003320 catalytic Zn binding site [ion binding]; other site 1246995003321 substrate binding site [chemical binding]; other site 1246995003322 structural Zn binding site [ion binding]; other site 1246995003323 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1246995003324 alpha-glucosidase; Provisional; Region: PRK10137 1246995003325 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 1246995003326 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1246995003327 active site 1246995003328 DNA binding site [nucleotide binding] 1246995003329 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1246995003330 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1246995003331 FAD binding domain; Region: FAD_binding_3; pfam01494 1246995003332 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1246995003333 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1246995003334 D-pathway; other site 1246995003335 Putative ubiquinol binding site [chemical binding]; other site 1246995003336 Low-spin heme (heme b) binding site [chemical binding]; other site 1246995003337 Putative water exit pathway; other site 1246995003338 Binuclear center (heme o3/CuB) [ion binding]; other site 1246995003339 K-pathway; other site 1246995003340 Putative proton exit pathway; other site 1246995003341 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1246995003342 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1246995003343 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1246995003344 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1246995003345 NAD binding site [chemical binding]; other site 1246995003346 substrate binding site [chemical binding]; other site 1246995003347 putative active site [active] 1246995003348 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1246995003349 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1246995003350 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 1246995003351 Isochorismatase family; Region: Isochorismatase; pfam00857 1246995003352 catalytic triad [active] 1246995003353 metal binding site [ion binding]; metal-binding site 1246995003354 conserved cis-peptide bond; other site 1246995003355 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1246995003356 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1246995003357 active site 1246995003358 AAA ATPase domain; Region: AAA_16; pfam13191 1246995003359 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995003360 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995003361 DNA binding residues [nucleotide binding] 1246995003362 dimerization interface [polypeptide binding]; other site 1246995003363 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 1246995003364 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 1246995003365 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1246995003366 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1246995003367 active site 1246995003368 catalytic tetrad [active] 1246995003369 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 1246995003370 MPN+ (JAMM) motif; other site 1246995003371 Zinc-binding site [ion binding]; other site 1246995003372 Ubiquitin-like proteins; Region: UBQ; cl00155 1246995003373 charged pocket; other site 1246995003374 hydrophobic patch; other site 1246995003375 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1246995003376 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1246995003377 dimer interface [polypeptide binding]; other site 1246995003378 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1246995003379 catalytic residue [active] 1246995003380 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1246995003381 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1246995003382 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1246995003383 ribonuclease PH; Reviewed; Region: rph; PRK00173 1246995003384 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1246995003385 hexamer interface [polypeptide binding]; other site 1246995003386 active site 1246995003387 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1246995003388 active site 1246995003389 dimerization interface [polypeptide binding]; other site 1246995003390 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1246995003391 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995003392 Walker A/P-loop; other site 1246995003393 ATP binding site [chemical binding]; other site 1246995003394 Q-loop/lid; other site 1246995003395 ABC transporter signature motif; other site 1246995003396 Walker B; other site 1246995003397 D-loop; other site 1246995003398 H-loop/switch region; other site 1246995003399 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 1246995003400 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1246995003401 TPR motif; other site 1246995003402 binding surface 1246995003403 Capsular polysaccharide synthesis protein; Region: Caps_synth; pfam05704 1246995003404 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 1246995003405 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1246995003406 active sites [active] 1246995003407 tetramer interface [polypeptide binding]; other site 1246995003408 imidazolonepropionase; Provisional; Region: PRK14085 1246995003409 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1246995003410 active site 1246995003411 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 1246995003412 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1246995003413 active site 1246995003414 allantoate amidohydrolase; Reviewed; Region: PRK09290 1246995003415 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1246995003416 active site 1246995003417 metal binding site [ion binding]; metal-binding site 1246995003418 dimer interface [polypeptide binding]; other site 1246995003419 urocanate hydratase; Provisional; Region: PRK05414 1246995003420 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1246995003421 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1246995003422 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1246995003423 putative active site [active] 1246995003424 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 1246995003425 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 1246995003426 MOSC domain; Region: MOSC; pfam03473 1246995003427 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1246995003428 Endoglucanase C-terminal domain/subunit and related proteins [Carbohydrate transport and metabolism]; Region: COG4305 1246995003429 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1246995003430 Coenzyme A binding pocket [chemical binding]; other site 1246995003431 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1246995003432 active site 1246995003433 Winged helix-turn helix; Region: HTH_29; pfam13551 1246995003434 Predicted transcriptional regulators [Transcription]; Region: COG1695 1246995003435 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1246995003436 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 1246995003437 SnoaL-like domain; Region: SnoaL_2; pfam12680 1246995003438 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 1246995003439 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1246995003440 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 1246995003441 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1246995003442 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1246995003443 dimerization interface [polypeptide binding]; other site 1246995003444 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1246995003445 dimer interface [polypeptide binding]; other site 1246995003446 putative CheW interface [polypeptide binding]; other site 1246995003447 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1246995003448 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1246995003449 catalytic triad [active] 1246995003450 Thioredoxin; Region: Thioredoxin_4; cl17273 1246995003451 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1246995003452 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1246995003453 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995003454 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1246995003455 DNA binding residues [nucleotide binding] 1246995003456 CopC domain; Region: CopC; pfam04234 1246995003457 Copper resistance protein D; Region: CopD; cl00563 1246995003458 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1246995003459 catalytic site [active] 1246995003460 putative active site [active] 1246995003461 putative substrate binding site [chemical binding]; other site 1246995003462 dimer interface [polypeptide binding]; other site 1246995003463 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1246995003464 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1246995003465 DNA binding site [nucleotide binding] 1246995003466 active site 1246995003467 Int/Topo IB signature motif; other site 1246995003468 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 1246995003469 polymerase nucleotide-binding site; other site 1246995003470 DNA-binding residues [nucleotide binding]; DNA binding site 1246995003471 nucleotide binding site [chemical binding]; other site 1246995003472 primase nucleotide-binding site [nucleotide binding]; other site 1246995003473 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1246995003474 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1246995003475 cofactor binding site; other site 1246995003476 DNA binding site [nucleotide binding] 1246995003477 substrate interaction site [chemical binding]; other site 1246995003478 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1246995003479 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1246995003480 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1246995003481 nudix motif; other site 1246995003482 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1246995003483 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1246995003484 DNA-binding site [nucleotide binding]; DNA binding site 1246995003485 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1246995003486 dimer interface [polypeptide binding]; other site 1246995003487 active site 1246995003488 ADP-ribose binding site [chemical binding]; other site 1246995003489 nudix motif; other site 1246995003490 metal binding site [ion binding]; metal-binding site 1246995003491 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 1246995003492 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1246995003493 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1246995003494 AAA ATPase domain; Region: AAA_16; pfam13191 1246995003495 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1246995003496 Patatin-like phospholipase; Region: Patatin; pfam01734 1246995003497 nucleophile elbow; other site 1246995003498 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1246995003499 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1246995003500 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1246995003501 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995003502 dimer interface [polypeptide binding]; other site 1246995003503 conserved gate region; other site 1246995003504 ABC-ATPase subunit interface; other site 1246995003505 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995003506 dimer interface [polypeptide binding]; other site 1246995003507 conserved gate region; other site 1246995003508 putative PBP binding loops; other site 1246995003509 ABC-ATPase subunit interface; other site 1246995003510 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1246995003511 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 1246995003512 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1246995003513 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995003514 Walker A/P-loop; other site 1246995003515 ATP binding site [chemical binding]; other site 1246995003516 Q-loop/lid; other site 1246995003517 ABC transporter signature motif; other site 1246995003518 Walker B; other site 1246995003519 D-loop; other site 1246995003520 H-loop/switch region; other site 1246995003521 TOBE domain; Region: TOBE_2; pfam08402 1246995003522 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 1246995003523 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 1246995003524 tetrameric interface [polypeptide binding]; other site 1246995003525 NAD binding site [chemical binding]; other site 1246995003526 catalytic residues [active] 1246995003527 substrate binding site [chemical binding]; other site 1246995003528 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1246995003529 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1246995003530 Walker A motif; other site 1246995003531 ATP binding site [chemical binding]; other site 1246995003532 Walker B motif; other site 1246995003533 arginine finger; other site 1246995003534 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 1246995003535 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1246995003536 metal ion-dependent adhesion site (MIDAS); other site 1246995003537 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 1246995003538 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1246995003539 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 1246995003540 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995003541 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1246995003542 DNA binding residues [nucleotide binding] 1246995003543 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 1246995003544 Asp-box motif; other site 1246995003545 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995003546 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995003547 active site 1246995003548 phosphorylation site [posttranslational modification] 1246995003549 intermolecular recognition site; other site 1246995003550 dimerization interface [polypeptide binding]; other site 1246995003551 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995003552 DNA binding residues [nucleotide binding] 1246995003553 dimerization interface [polypeptide binding]; other site 1246995003554 Histidine kinase; Region: HisKA_3; pfam07730 1246995003555 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1246995003556 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1246995003557 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995003558 Walker A/P-loop; other site 1246995003559 ATP binding site [chemical binding]; other site 1246995003560 Q-loop/lid; other site 1246995003561 ABC transporter signature motif; other site 1246995003562 Walker B; other site 1246995003563 D-loop; other site 1246995003564 H-loop/switch region; other site 1246995003565 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995003566 Walker A/P-loop; other site 1246995003567 ATP binding site [chemical binding]; other site 1246995003568 ABC transporter; Region: ABC_tran; pfam00005 1246995003569 Q-loop/lid; other site 1246995003570 ABC transporter signature motif; other site 1246995003571 Walker B; other site 1246995003572 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 1246995003573 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1246995003574 DNA binding residues [nucleotide binding] 1246995003575 drug binding residues [chemical binding]; other site 1246995003576 dimer interface [polypeptide binding]; other site 1246995003577 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1246995003578 active site 1246995003579 catalytic residues [active] 1246995003580 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1246995003581 Interdomain contacts; other site 1246995003582 Cytokine receptor motif; other site 1246995003583 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 1246995003584 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1246995003585 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1246995003586 Bacterial Ig-like domain; Region: Big_5; pfam13205 1246995003587 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 1246995003588 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1246995003589 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1246995003590 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 1246995003591 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 1246995003592 MOSC domain; Region: MOSC; pfam03473 1246995003593 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1246995003594 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1246995003595 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1246995003596 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1246995003597 binding surface 1246995003598 TPR motif; other site 1246995003599 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1246995003600 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1246995003601 binding surface 1246995003602 TPR motif; other site 1246995003603 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1246995003604 PRC-barrel domain; Region: PRC; pfam05239 1246995003605 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1246995003606 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995003607 active site 1246995003608 phosphorylation site [posttranslational modification] 1246995003609 intermolecular recognition site; other site 1246995003610 dimerization interface [polypeptide binding]; other site 1246995003611 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 1246995003612 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1246995003613 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 1246995003614 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1246995003615 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1246995003616 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1246995003617 ATP binding site [chemical binding]; other site 1246995003618 Walker A motif; other site 1246995003619 hexamer interface [polypeptide binding]; other site 1246995003620 Walker B motif; other site 1246995003621 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1246995003622 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1246995003623 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 1246995003624 Flp/Fap pilin component; Region: Flp_Fap; cl01585 1246995003625 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 1246995003626 Protein of unknown function (DUF2000); Region: DUF2000; cl02074 1246995003627 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1246995003628 putative DNA binding site [nucleotide binding]; other site 1246995003629 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1246995003630 putative Zn2+ binding site [ion binding]; other site 1246995003631 AsnC family; Region: AsnC_trans_reg; pfam01037 1246995003632 Predicted membrane protein (DUF2238); Region: DUF2238; pfam09997 1246995003633 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1246995003634 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1246995003635 Coenzyme A binding pocket [chemical binding]; other site 1246995003636 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1246995003637 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1246995003638 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 1246995003639 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 1246995003640 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1246995003641 oligomer interface [polypeptide binding]; other site 1246995003642 metal binding site [ion binding]; metal-binding site 1246995003643 metal binding site [ion binding]; metal-binding site 1246995003644 putative Cl binding site [ion binding]; other site 1246995003645 basic sphincter; other site 1246995003646 hydrophobic gate; other site 1246995003647 periplasmic entrance; other site 1246995003648 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1246995003649 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1246995003650 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1246995003651 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995003652 Walker A/P-loop; other site 1246995003653 ATP binding site [chemical binding]; other site 1246995003654 Q-loop/lid; other site 1246995003655 ABC transporter signature motif; other site 1246995003656 Walker B; other site 1246995003657 D-loop; other site 1246995003658 H-loop/switch region; other site 1246995003659 Predicted transcriptional regulator [Transcription]; Region: COG2378 1246995003660 HTH domain; Region: HTH_11; pfam08279 1246995003661 WYL domain; Region: WYL; pfam13280 1246995003662 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1246995003663 active site 1246995003664 Domain of unknown function (DUF1768); Region: DUF1768; pfam08719 1246995003665 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1246995003666 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1246995003667 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1246995003668 dimerization interface [polypeptide binding]; other site 1246995003669 putative DNA binding site [nucleotide binding]; other site 1246995003670 putative Zn2+ binding site [ion binding]; other site 1246995003671 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893 1246995003672 putative hydrophobic ligand binding site [chemical binding]; other site 1246995003673 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1246995003674 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1246995003675 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 1246995003676 nudix motif; other site 1246995003677 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1246995003678 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1246995003679 Coenzyme A binding pocket [chemical binding]; other site 1246995003680 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1246995003681 A subgroup of the Glycosyl hydrolase family 20 (GH20) catalytic domain found in proteins similar to the N-acetylhexosaminidase from Streptomyces plicatus (SpHex). SpHex catalyzes the hydrolysis of N-acetyl-beta-hexosaminides. An Asp residue within the...; Region: GH20_SpHex_like; cd06568 1246995003682 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 1246995003683 active site 1246995003684 Peptidase family M48; Region: Peptidase_M48; cl12018 1246995003685 deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026 1246995003686 Predicted transcriptional regulator [Transcription]; Region: COG2378 1246995003687 HTH domain; Region: HTH_11; pfam08279 1246995003688 WYL domain; Region: WYL; pfam13280 1246995003689 Nitrate and nitrite sensing; Region: NIT; pfam08376 1246995003690 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1246995003691 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1246995003692 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995003693 ATP binding site [chemical binding]; other site 1246995003694 Mg2+ binding site [ion binding]; other site 1246995003695 G-X-G motif; other site 1246995003696 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 1246995003697 Protein of unknown function (DUF742); Region: DUF742; pfam05331 1246995003698 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1246995003699 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 1246995003700 G1 box; other site 1246995003701 GTP/Mg2+ binding site [chemical binding]; other site 1246995003702 G2 box; other site 1246995003703 Switch I region; other site 1246995003704 G3 box; other site 1246995003705 Switch II region; other site 1246995003706 G4 box; other site 1246995003707 G5 box; other site 1246995003708 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1246995003709 DNA binding site [nucleotide binding] 1246995003710 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1246995003711 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1246995003712 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 1246995003713 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1246995003714 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1246995003715 metal ion-dependent adhesion site (MIDAS); other site 1246995003716 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 1246995003717 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1246995003718 MarR family; Region: MarR; pfam01047 1246995003719 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1246995003720 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1246995003721 xylose isomerase, Arthrobacter type; Region: xylA_Arthro; TIGR02631 1246995003722 xylose isomerase; Provisional; Region: PRK12677 1246995003723 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1246995003724 D-xylulose kinase; Region: XylB; TIGR01312 1246995003725 nucleotide binding site [chemical binding]; other site 1246995003726 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1246995003727 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1246995003728 putative substrate translocation pore; other site 1246995003729 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1246995003730 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 1246995003731 active site 1246995003732 catalytic site [active] 1246995003733 HD domain; Region: HD_4; pfam13328 1246995003734 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 1246995003735 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1246995003736 active site 1246995003737 metal binding site [ion binding]; metal-binding site 1246995003738 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1246995003739 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 1246995003740 TMP-binding site; other site 1246995003741 ATP-binding site [chemical binding]; other site 1246995003742 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995003743 NAD(P) binding site [chemical binding]; other site 1246995003744 active site 1246995003745 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1246995003746 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1246995003747 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995003748 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1246995003749 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1246995003750 DNA binding residues [nucleotide binding] 1246995003751 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1246995003752 NlpC/P60 family; Region: NLPC_P60; pfam00877 1246995003753 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 1246995003754 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 1246995003755 GAF domain; Region: GAF; cl17456 1246995003756 ANTAR domain; Region: ANTAR; pfam03861 1246995003757 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1246995003758 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1246995003759 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1246995003760 putative substrate translocation pore; other site 1246995003761 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1246995003762 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1246995003763 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1246995003764 putative DNA binding site [nucleotide binding]; other site 1246995003765 putative Zn2+ binding site [ion binding]; other site 1246995003766 Predicted methyltransferase [General function prediction only]; Region: COG3897 1246995003767 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1246995003768 DNA binding site [nucleotide binding] 1246995003769 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995003770 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995003771 active site 1246995003772 phosphorylation site [posttranslational modification] 1246995003773 intermolecular recognition site; other site 1246995003774 dimerization interface [polypeptide binding]; other site 1246995003775 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995003776 DNA binding residues [nucleotide binding] 1246995003777 dimerization interface [polypeptide binding]; other site 1246995003778 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 1246995003779 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 1246995003780 ligand binding site [chemical binding]; other site 1246995003781 NAD binding site [chemical binding]; other site 1246995003782 tetramer interface [polypeptide binding]; other site 1246995003783 catalytic site [active] 1246995003784 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 1246995003785 L-serine binding site [chemical binding]; other site 1246995003786 ACT domain interface; other site 1246995003787 Phosphotransferase enzyme family; Region: APH; pfam01636 1246995003788 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1246995003789 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995003790 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1246995003791 Walker A/P-loop; other site 1246995003792 ATP binding site [chemical binding]; other site 1246995003793 Q-loop/lid; other site 1246995003794 ABC transporter signature motif; other site 1246995003795 Walker B; other site 1246995003796 D-loop; other site 1246995003797 H-loop/switch region; other site 1246995003798 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1246995003799 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1246995003800 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1246995003801 MarR family; Region: MarR; pfam01047 1246995003802 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1246995003803 hypothetical protein; Provisional; Region: PRK07236 1246995003804 Biofilm formation and stress response factor; Region: BsmA; pfam10014 1246995003805 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1246995003806 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1246995003807 dimerization interface [polypeptide binding]; other site 1246995003808 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1246995003809 dimer interface [polypeptide binding]; other site 1246995003810 phosphorylation site [posttranslational modification] 1246995003811 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995003812 ATP binding site [chemical binding]; other site 1246995003813 Mg2+ binding site [ion binding]; other site 1246995003814 G-X-G motif; other site 1246995003815 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1246995003816 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995003817 active site 1246995003818 phosphorylation site [posttranslational modification] 1246995003819 intermolecular recognition site; other site 1246995003820 dimerization interface [polypeptide binding]; other site 1246995003821 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1246995003822 DNA binding site [nucleotide binding] 1246995003823 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1246995003824 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1246995003825 HlyD family secretion protein; Region: HlyD_3; pfam13437 1246995003826 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1246995003827 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1246995003828 Walker A/P-loop; other site 1246995003829 ATP binding site [chemical binding]; other site 1246995003830 Q-loop/lid; other site 1246995003831 ABC transporter signature motif; other site 1246995003832 Walker B; other site 1246995003833 D-loop; other site 1246995003834 H-loop/switch region; other site 1246995003835 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1246995003836 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1246995003837 FtsX-like permease family; Region: FtsX; pfam02687 1246995003838 YCII-related domain; Region: YCII; cl00999 1246995003839 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 1246995003840 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 1246995003841 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995003842 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1246995003843 DNA binding residues [nucleotide binding] 1246995003844 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 1246995003845 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1246995003846 chromosome segregation protein; Provisional; Region: PRK02224 1246995003847 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1246995003848 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1246995003849 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1246995003850 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1246995003851 dimer interface [polypeptide binding]; other site 1246995003852 ssDNA binding site [nucleotide binding]; other site 1246995003853 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1246995003854 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 1246995003855 cobyric acid synthase; Provisional; Region: PRK00784 1246995003856 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1246995003857 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1246995003858 catalytic triad [active] 1246995003859 hypothetical protein; Provisional; Region: PRK06547 1246995003860 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1246995003861 hypothetical protein; Provisional; Region: PRK07907 1246995003862 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 1246995003863 active site 1246995003864 metal binding site [ion binding]; metal-binding site 1246995003865 dimer interface [polypeptide binding]; other site 1246995003866 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1246995003867 FAD binding domain; Region: FAD_binding_3; pfam01494 1246995003868 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1246995003869 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1246995003870 active site 1246995003871 motif I; other site 1246995003872 motif II; other site 1246995003873 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1246995003874 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 1246995003875 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015 1246995003876 active site 1246995003877 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 1246995003878 DNA binding site [nucleotide binding] 1246995003879 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 1246995003880 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 1246995003881 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1246995003882 conserved cys residue [active] 1246995003883 TIGR03086 family protein; Region: TIGR03086 1246995003884 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1246995003885 Transglycosylase; Region: Transgly; pfam00912 1246995003886 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1246995003887 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1246995003888 threonine-phosphate decarboxylase; Provisional; Region: PRK06358 1246995003889 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1246995003890 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1246995003891 homodimer interface [polypeptide binding]; other site 1246995003892 catalytic residue [active] 1246995003893 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1246995003894 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1246995003895 putative dimer interface [polypeptide binding]; other site 1246995003896 active site pocket [active] 1246995003897 putative cataytic base [active] 1246995003898 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1246995003899 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1246995003900 active site 1246995003901 SAM binding site [chemical binding]; other site 1246995003902 homodimer interface [polypeptide binding]; other site 1246995003903 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1246995003904 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1246995003905 active site 1246995003906 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 1246995003907 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1246995003908 active site 1246995003909 homotetramer interface [polypeptide binding]; other site 1246995003910 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1246995003911 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1246995003912 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1246995003913 ABC transporter; Region: ABC_tran_2; pfam12848 1246995003914 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1246995003915 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1246995003916 active site 1246995003917 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1246995003918 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1246995003919 apolar tunnel; other site 1246995003920 heme binding site [chemical binding]; other site 1246995003921 dimerization interface [polypeptide binding]; other site 1246995003922 H+ Antiporter protein; Region: 2A0121; TIGR00900 1246995003923 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1246995003924 putative substrate translocation pore; other site 1246995003925 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1246995003926 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1246995003927 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1246995003928 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1246995003929 active site 1246995003930 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 1246995003931 active site 1246995003932 putative catalytic site [active] 1246995003933 Predicted membrane protein [Function unknown]; Region: COG1470 1246995003934 Repair protein; Region: Repair_PSII; pfam04536 1246995003935 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1246995003936 putative active site [active] 1246995003937 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 1246995003938 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 1246995003939 Zn binding site [ion binding]; other site 1246995003940 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 1246995003941 catalytic residues [active] 1246995003942 Uncharacterized conserved protein [Function unknown]; Region: COG4198 1246995003943 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1246995003944 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1246995003945 substrate binding pocket [chemical binding]; other site 1246995003946 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1246995003947 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1246995003948 hypothetical protein; Provisional; Region: PRK01346 1246995003949 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1246995003950 Coenzyme A binding pocket [chemical binding]; other site 1246995003951 oxidoreductase; Provisional; Region: PRK06128 1246995003952 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1246995003953 NAD binding site [chemical binding]; other site 1246995003954 metal binding site [ion binding]; metal-binding site 1246995003955 active site 1246995003956 Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081 1246995003957 Ca binding site [ion binding]; other site 1246995003958 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1246995003959 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1246995003960 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 1246995003961 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1246995003962 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1246995003963 trigger factor; Provisional; Region: tig; PRK01490 1246995003964 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1246995003965 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1246995003966 Clp protease; Region: CLP_protease; pfam00574 1246995003967 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1246995003968 oligomer interface [polypeptide binding]; other site 1246995003969 active site residues [active] 1246995003970 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 1246995003971 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1246995003972 oligomer interface [polypeptide binding]; other site 1246995003973 active site residues [active] 1246995003974 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1246995003975 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1246995003976 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1246995003977 Walker A motif; other site 1246995003978 ATP binding site [chemical binding]; other site 1246995003979 Walker B motif; other site 1246995003980 arginine finger; other site 1246995003981 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1246995003982 nitrilase; Region: PLN02798 1246995003983 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 1246995003984 putative active site [active] 1246995003985 catalytic triad [active] 1246995003986 dimer interface [polypeptide binding]; other site 1246995003987 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1246995003988 active site 1246995003989 active site 1246995003990 metal binding site [ion binding]; metal-binding site 1246995003991 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 1246995003992 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1246995003993 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1246995003994 HIGH motif; other site 1246995003995 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1246995003996 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1246995003997 active site 1246995003998 KMSKS motif; other site 1246995003999 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1246995004000 tRNA binding surface [nucleotide binding]; other site 1246995004001 anticodon binding site; other site 1246995004002 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1246995004003 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1246995004004 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1246995004005 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1246995004006 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1246995004007 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1246995004008 active site 1246995004009 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1246995004010 active site 1246995004011 multimer interface [polypeptide binding]; other site 1246995004012 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1246995004013 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1246995004014 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 1246995004015 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1246995004016 putative active site [active] 1246995004017 putative metal binding site [ion binding]; other site 1246995004018 Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060 1246995004019 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1246995004020 HIGH motif; other site 1246995004021 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1246995004022 active site 1246995004023 KMSKS motif; other site 1246995004024 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 1246995004025 tRNA binding surface [nucleotide binding]; other site 1246995004026 anticodon binding site; other site 1246995004027 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1246995004028 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1246995004029 putative acyl-acceptor binding pocket; other site 1246995004030 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 1246995004031 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 1246995004032 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 1246995004033 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1246995004034 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1246995004035 PAS domain; Region: PAS_9; pfam13426 1246995004036 putative active site [active] 1246995004037 heme pocket [chemical binding]; other site 1246995004038 GAF domain; Region: GAF_3; pfam13492 1246995004039 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1246995004040 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1246995004041 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1246995004042 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1246995004043 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1246995004044 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1246995004045 anti sigma factor interaction site; other site 1246995004046 regulatory phosphorylation site [posttranslational modification]; other site 1246995004047 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 1246995004048 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1246995004049 B12 binding site [chemical binding]; other site 1246995004050 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1246995004051 FeS/SAM binding site; other site 1246995004052 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 1246995004053 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 1246995004054 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1246995004055 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1246995004056 homodimer interface [polypeptide binding]; other site 1246995004057 oligonucleotide binding site [chemical binding]; other site 1246995004058 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1246995004059 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1246995004060 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1246995004061 GTPase CgtA; Reviewed; Region: obgE; PRK12296 1246995004062 GTP1/OBG; Region: GTP1_OBG; pfam01018 1246995004063 Obg GTPase; Region: Obg; cd01898 1246995004064 G1 box; other site 1246995004065 GTP/Mg2+ binding site [chemical binding]; other site 1246995004066 Switch I region; other site 1246995004067 G2 box; other site 1246995004068 G3 box; other site 1246995004069 Switch II region; other site 1246995004070 G4 box; other site 1246995004071 G5 box; other site 1246995004072 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1246995004073 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1246995004074 Coenzyme A binding pocket [chemical binding]; other site 1246995004075 Ricin-type beta-trefoil; Region: RICIN; smart00458 1246995004076 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1246995004077 putative sugar binding sites [chemical binding]; other site 1246995004078 Q-X-W motif; other site 1246995004079 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1246995004080 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1246995004081 putative sugar binding sites [chemical binding]; other site 1246995004082 Q-X-W motif; other site 1246995004083 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 1246995004084 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 1246995004085 Zn binding site [ion binding]; other site 1246995004086 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1246995004087 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1246995004088 putative active site [active] 1246995004089 heme pocket [chemical binding]; other site 1246995004090 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1246995004091 dimer interface [polypeptide binding]; other site 1246995004092 phosphorylation site [posttranslational modification] 1246995004093 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995004094 ATP binding site [chemical binding]; other site 1246995004095 Mg2+ binding site [ion binding]; other site 1246995004096 G-X-G motif; other site 1246995004097 Response regulator receiver domain; Region: Response_reg; pfam00072 1246995004098 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995004099 active site 1246995004100 phosphorylation site [posttranslational modification] 1246995004101 intermolecular recognition site; other site 1246995004102 dimerization interface [polypeptide binding]; other site 1246995004103 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1246995004104 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1246995004105 active site 1246995004106 (T/H)XGH motif; other site 1246995004107 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 1246995004108 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1246995004109 catalytic core [active] 1246995004110 EDD domain protein, DegV family; Region: DegV; TIGR00762 1246995004111 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1246995004112 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1246995004113 SLBB domain; Region: SLBB; pfam10531 1246995004114 comEA protein; Region: comE; TIGR01259 1246995004115 Competence protein; Region: Competence; pfam03772 1246995004116 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 1246995004117 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995004118 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1246995004119 NAD(P) binding site [chemical binding]; other site 1246995004120 active site 1246995004121 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 1246995004122 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 1246995004123 DNA polymerase III, delta subunit; Region: holA; TIGR01128 1246995004124 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1246995004125 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1246995004126 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1246995004127 Phosphotransferase enzyme family; Region: APH; pfam01636 1246995004128 active site 1246995004129 ATP binding site [chemical binding]; other site 1246995004130 Protein of unknown function (DUF4240); Region: DUF4240; pfam14024 1246995004131 molybdenum cofactor biosynthesis protein MoaC/MOSC-domain-containing protein; Provisional; Region: PRK14499 1246995004132 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1246995004133 GTP-binding protein LepA; Provisional; Region: PRK05433 1246995004134 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1246995004135 G1 box; other site 1246995004136 putative GEF interaction site [polypeptide binding]; other site 1246995004137 GTP/Mg2+ binding site [chemical binding]; other site 1246995004138 Switch I region; other site 1246995004139 G2 box; other site 1246995004140 G3 box; other site 1246995004141 Switch II region; other site 1246995004142 G4 box; other site 1246995004143 G5 box; other site 1246995004144 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1246995004145 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1246995004146 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1246995004147 Predicted membrane protein [Function unknown]; Region: COG2261 1246995004148 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1246995004149 PAS domain; Region: PAS_9; pfam13426 1246995004150 putative active site [active] 1246995004151 heme pocket [chemical binding]; other site 1246995004152 enoyl-CoA hydratase; Provisional; Region: PRK07827 1246995004153 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1246995004154 substrate binding site [chemical binding]; other site 1246995004155 oxyanion hole (OAH) forming residues; other site 1246995004156 trimer interface [polypeptide binding]; other site 1246995004157 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 1246995004158 coproporphyrinogen III oxidase; Validated; Region: PRK05628 1246995004159 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1246995004160 FeS/SAM binding site; other site 1246995004161 Tic20-like protein; Region: Tic20; pfam09685 1246995004162 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1246995004163 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1246995004164 chaperone protein DnaJ; Provisional; Region: PRK14278 1246995004165 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1246995004166 HSP70 interaction site [polypeptide binding]; other site 1246995004167 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1246995004168 Zn binding sites [ion binding]; other site 1246995004169 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1246995004170 dimer interface [polypeptide binding]; other site 1246995004171 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 1246995004172 RNA methyltransferase, RsmE family; Region: TIGR00046 1246995004173 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1246995004174 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1246995004175 ABC-ATPase subunit interface; other site 1246995004176 dimer interface [polypeptide binding]; other site 1246995004177 putative PBP binding regions; other site 1246995004178 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1246995004179 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1246995004180 ABC-ATPase subunit interface; other site 1246995004181 dimer interface [polypeptide binding]; other site 1246995004182 putative PBP binding regions; other site 1246995004183 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1246995004184 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1246995004185 Walker A/P-loop; other site 1246995004186 ATP binding site [chemical binding]; other site 1246995004187 Q-loop/lid; other site 1246995004188 ABC transporter signature motif; other site 1246995004189 Walker B; other site 1246995004190 D-loop; other site 1246995004191 H-loop/switch region; other site 1246995004192 MbtH-like protein; Region: MbtH; pfam03621 1246995004193 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1246995004194 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1246995004195 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1246995004196 Walker A/P-loop; other site 1246995004197 ATP binding site [chemical binding]; other site 1246995004198 Q-loop/lid; other site 1246995004199 ABC transporter signature motif; other site 1246995004200 Walker B; other site 1246995004201 D-loop; other site 1246995004202 H-loop/switch region; other site 1246995004203 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1246995004204 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1246995004205 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995004206 Walker A/P-loop; other site 1246995004207 ATP binding site [chemical binding]; other site 1246995004208 Q-loop/lid; other site 1246995004209 ABC transporter signature motif; other site 1246995004210 Walker B; other site 1246995004211 D-loop; other site 1246995004212 H-loop/switch region; other site 1246995004213 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1246995004214 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1246995004215 intersubunit interface [polypeptide binding]; other site 1246995004216 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1246995004217 tetramerization interface [polypeptide binding]; other site 1246995004218 active site 1246995004219 classical (c) SDRs; Region: SDR_c; cd05233 1246995004220 NAD(P) binding site [chemical binding]; other site 1246995004221 active site 1246995004222 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 1246995004223 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 1246995004224 active site 1246995004225 substrate binding site [chemical binding]; other site 1246995004226 cosubstrate binding site; other site 1246995004227 catalytic site [active] 1246995004228 Formyl transferase, C-terminal domain; Region: Formyl_trans_C; pfam02911 1246995004229 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 1246995004230 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1246995004231 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1246995004232 Coenzyme A binding pocket [chemical binding]; other site 1246995004233 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1246995004234 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1246995004235 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1246995004236 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1246995004237 classical (c) SDRs; Region: SDR_c; cd05233 1246995004238 NAD(P) binding site [chemical binding]; other site 1246995004239 active site 1246995004240 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 1246995004241 nucleotide binding site/active site [active] 1246995004242 HIT family signature motif; other site 1246995004243 catalytic residue [active] 1246995004244 Beta-lactamase; Region: Beta-lactamase; pfam00144 1246995004245 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1246995004246 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1246995004247 PhoH-like protein; Region: PhoH; pfam02562 1246995004248 metal-binding heat shock protein; Provisional; Region: PRK00016 1246995004249 Domain of unknown function DUF21; Region: DUF21; pfam01595 1246995004250 FOG: CBS domain [General function prediction only]; Region: COG0517 1246995004251 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1246995004252 Transporter associated domain; Region: CorC_HlyC; smart01091 1246995004253 GTPase Era; Reviewed; Region: era; PRK00089 1246995004254 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1246995004255 G1 box; other site 1246995004256 GTP/Mg2+ binding site [chemical binding]; other site 1246995004257 Switch I region; other site 1246995004258 G2 box; other site 1246995004259 Switch II region; other site 1246995004260 G3 box; other site 1246995004261 G4 box; other site 1246995004262 G5 box; other site 1246995004263 KH domain; Region: KH_2; pfam07650 1246995004264 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1246995004265 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1246995004266 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1246995004267 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1246995004268 Recombination protein O N terminal; Region: RecO_N; pfam11967 1246995004269 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1246995004270 Recombination protein O C terminal; Region: RecO_C; pfam02565 1246995004271 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 1246995004272 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 1246995004273 catalytic residue [active] 1246995004274 putative FPP diphosphate binding site; other site 1246995004275 putative FPP binding hydrophobic cleft; other site 1246995004276 dimer interface [polypeptide binding]; other site 1246995004277 putative IPP diphosphate binding site; other site 1246995004278 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 1246995004279 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1246995004280 Acid Phosphatase; Region: Acid_PPase; cl17256 1246995004281 Domain of unknown function DUF77; Region: DUF77; pfam01910 1246995004282 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 1246995004283 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 1246995004284 RDD family; Region: RDD; pfam06271 1246995004285 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1246995004286 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1246995004287 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1246995004288 Walker A/P-loop; other site 1246995004289 ATP binding site [chemical binding]; other site 1246995004290 Q-loop/lid; other site 1246995004291 ABC transporter signature motif; other site 1246995004292 Walker B; other site 1246995004293 D-loop; other site 1246995004294 H-loop/switch region; other site 1246995004295 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1246995004296 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 1246995004297 Walker A/P-loop; other site 1246995004298 ATP binding site [chemical binding]; other site 1246995004299 Q-loop/lid; other site 1246995004300 ABC transporter signature motif; other site 1246995004301 Walker B; other site 1246995004302 D-loop; other site 1246995004303 H-loop/switch region; other site 1246995004304 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 1246995004305 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1246995004306 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1246995004307 metal binding site 2 [ion binding]; metal-binding site 1246995004308 putative DNA binding helix; other site 1246995004309 metal binding site 1 [ion binding]; metal-binding site 1246995004310 dimer interface [polypeptide binding]; other site 1246995004311 structural Zn2+ binding site [ion binding]; other site 1246995004312 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1246995004313 dimerization interface [polypeptide binding]; other site 1246995004314 putative DNA binding site [nucleotide binding]; other site 1246995004315 putative Zn2+ binding site [ion binding]; other site 1246995004316 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1246995004317 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1246995004318 ABC-ATPase subunit interface; other site 1246995004319 dimer interface [polypeptide binding]; other site 1246995004320 putative PBP binding regions; other site 1246995004321 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1246995004322 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1246995004323 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1246995004324 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1246995004325 intersubunit interface [polypeptide binding]; other site 1246995004326 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 1246995004327 glycyl-tRNA synthetase; Provisional; Region: PRK04173 1246995004328 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1246995004329 motif 1; other site 1246995004330 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 1246995004331 active site 1246995004332 motif 2; other site 1246995004333 motif 3; other site 1246995004334 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 1246995004335 anticodon binding site; other site 1246995004336 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1246995004337 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1246995004338 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1246995004339 FMN binding site [chemical binding]; other site 1246995004340 active site 1246995004341 catalytic residues [active] 1246995004342 substrate binding site [chemical binding]; other site 1246995004343 NIPSNAP; Region: NIPSNAP; pfam07978 1246995004344 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 1246995004345 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1246995004346 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 1246995004347 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1246995004348 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1246995004349 active site 1246995004350 metal binding site [ion binding]; metal-binding site 1246995004351 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1246995004352 dimerization interface [polypeptide binding]; other site 1246995004353 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1246995004354 dimer interface [polypeptide binding]; other site 1246995004355 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1246995004356 putative CheW interface [polypeptide binding]; other site 1246995004357 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 1246995004358 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1246995004359 Zn2+ binding site [ion binding]; other site 1246995004360 Mg2+ binding site [ion binding]; other site 1246995004361 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1246995004362 DNA primase; Validated; Region: dnaG; PRK05667 1246995004363 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1246995004364 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1246995004365 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1246995004366 active site 1246995004367 metal binding site [ion binding]; metal-binding site 1246995004368 interdomain interaction site; other site 1246995004369 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1246995004370 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 1246995004371 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1246995004372 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995004373 Walker A/P-loop; other site 1246995004374 ATP binding site [chemical binding]; other site 1246995004375 Q-loop/lid; other site 1246995004376 ABC transporter signature motif; other site 1246995004377 Walker B; other site 1246995004378 D-loop; other site 1246995004379 H-loop/switch region; other site 1246995004380 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1246995004381 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1246995004382 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1246995004383 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1246995004384 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1246995004385 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1246995004386 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1246995004387 nucleotide binding site [chemical binding]; other site 1246995004388 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1246995004389 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1246995004390 Walker A/P-loop; other site 1246995004391 ATP binding site [chemical binding]; other site 1246995004392 Q-loop/lid; other site 1246995004393 ABC transporter signature motif; other site 1246995004394 Walker B; other site 1246995004395 D-loop; other site 1246995004396 H-loop/switch region; other site 1246995004397 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1246995004398 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1246995004399 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1246995004400 TM-ABC transporter signature motif; other site 1246995004401 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1246995004402 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1246995004403 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1246995004404 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1246995004405 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1246995004406 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1246995004407 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1246995004408 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1246995004409 Metal-binding active site; metal-binding site 1246995004410 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 1246995004411 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 1246995004412 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1246995004413 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 1246995004414 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1246995004415 motif II; other site 1246995004416 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1246995004417 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 1246995004418 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1246995004419 homodimer interface [polypeptide binding]; other site 1246995004420 catalytic residue [active] 1246995004421 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cl10029 1246995004422 AAA ATPase domain; Region: AAA_16; pfam13191 1246995004423 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1246995004424 structural tetrad; other site 1246995004425 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1246995004426 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1246995004427 structural tetrad; other site 1246995004428 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1246995004429 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 1246995004430 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1246995004431 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 1246995004432 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1246995004433 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1246995004434 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1246995004435 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1246995004436 Coenzyme A binding pocket [chemical binding]; other site 1246995004437 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1246995004438 dimerization interface [polypeptide binding]; other site 1246995004439 putative DNA binding site [nucleotide binding]; other site 1246995004440 putative Zn2+ binding site [ion binding]; other site 1246995004441 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 1246995004442 amphipathic channel; other site 1246995004443 Asn-Pro-Ala signature motifs; other site 1246995004444 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1246995004445 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1246995004446 active site 1246995004447 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1246995004448 TPR motif; other site 1246995004449 binding surface 1246995004450 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1246995004451 CHAT domain; Region: CHAT; cl17868 1246995004452 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1246995004453 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995004454 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1246995004455 active site 1246995004456 catalytic residues [active] 1246995004457 RibD C-terminal domain; Region: RibD_C; cl17279 1246995004458 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1246995004459 Helix-turn-helix domain; Region: HTH_18; pfam12833 1246995004460 Domain of unknown function DUF87; Region: DUF87; pfam01935 1246995004461 AAA-like domain; Region: AAA_10; pfam12846 1246995004462 Zonular occludens toxin (Zot); Region: Zot; cl17485 1246995004463 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1246995004464 putative active site [active] 1246995004465 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 1246995004466 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1246995004467 putative metal binding site [ion binding]; other site 1246995004468 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995004469 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1246995004470 Domain of unknown function (DUF4386); Region: DUF4386; pfam14329 1246995004471 DinB superfamily; Region: DinB_2; pfam12867 1246995004472 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1246995004473 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1246995004474 non-specific DNA binding site [nucleotide binding]; other site 1246995004475 salt bridge; other site 1246995004476 sequence-specific DNA binding site [nucleotide binding]; other site 1246995004477 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1246995004478 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1246995004479 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250 1246995004480 30S subunit binding site; other site 1246995004481 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1246995004482 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1246995004483 NAD(P) binding site [chemical binding]; other site 1246995004484 catalytic residues [active] 1246995004485 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1246995004486 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1246995004487 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 1246995004488 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1246995004489 active site 1246995004490 ATP binding site [chemical binding]; other site 1246995004491 AAA ATPase domain; Region: AAA_16; pfam13191 1246995004492 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995004493 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995004494 DNA binding residues [nucleotide binding] 1246995004495 dimerization interface [polypeptide binding]; other site 1246995004496 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1246995004497 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_10; cd08865 1246995004498 putative hydrophobic ligand binding site [chemical binding]; other site 1246995004499 Short C-terminal domain; Region: SHOCT; pfam09851 1246995004500 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1246995004501 HAMP domain; Region: HAMP; pfam00672 1246995004502 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1246995004503 dimer interface [polypeptide binding]; other site 1246995004504 putative CheW interface [polypeptide binding]; other site 1246995004505 PilZ domain; Region: PilZ; pfam07238 1246995004506 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 1246995004507 active site 1246995004508 dihydroxyacetone kinase; Provisional; Region: PRK14479 1246995004509 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 1246995004510 DAK2 domain; Region: Dak2; cl03685 1246995004511 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1246995004512 arginine-tRNA ligase; Region: PLN02286 1246995004513 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1246995004514 active site 1246995004515 HIGH motif; other site 1246995004516 KMSK motif region; other site 1246995004517 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1246995004518 tRNA binding surface [nucleotide binding]; other site 1246995004519 anticodon binding site; other site 1246995004520 RDD family; Region: RDD; pfam06271 1246995004521 Integral membrane protein DUF95; Region: DUF95; pfam01944 1246995004522 Nitroreductase family; Region: Nitroreductase; pfam00881 1246995004523 FMN binding site [chemical binding]; other site 1246995004524 dimer interface [polypeptide binding]; other site 1246995004525 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1246995004526 Protein of unknown function DUF58; Region: DUF58; pfam01882 1246995004527 MoxR-like ATPases [General function prediction only]; Region: COG0714 1246995004528 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1246995004529 Walker A motif; other site 1246995004530 ATP binding site [chemical binding]; other site 1246995004531 Walker B motif; other site 1246995004532 arginine finger; other site 1246995004533 2',3'-cyclic-nucleotide 2'-phosphodiesterase; Region: CycNucDiestase; TIGR01390 1246995004534 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1246995004535 active site 1246995004536 metal binding site [ion binding]; metal-binding site 1246995004537 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1246995004538 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 1246995004539 Catalytic site [active] 1246995004540 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1246995004541 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 1246995004542 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1246995004543 DNA binding residues [nucleotide binding] 1246995004544 drug binding residues [chemical binding]; other site 1246995004545 dimer interface [polypeptide binding]; other site 1246995004546 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 1246995004547 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1246995004548 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1246995004549 active site 1246995004550 ATP binding site [chemical binding]; other site 1246995004551 substrate binding site [chemical binding]; other site 1246995004552 activation loop (A-loop); other site 1246995004553 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1246995004554 anti sigma factor interaction site; other site 1246995004555 regulatory phosphorylation site [posttranslational modification]; other site 1246995004556 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1246995004557 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1246995004558 active site 1246995004559 ATP binding site [chemical binding]; other site 1246995004560 substrate binding site [chemical binding]; other site 1246995004561 activation loop (A-loop); other site 1246995004562 Survival protein SurE; Region: SurE; cl00448 1246995004563 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1246995004564 substrate binding site [chemical binding]; other site 1246995004565 ATP binding site [chemical binding]; other site 1246995004566 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1246995004567 hypothetical protein; Provisional; Region: PRK07236 1246995004568 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995004569 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1246995004570 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1246995004571 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD_like; cd08296 1246995004572 putative NAD(P) binding site [chemical binding]; other site 1246995004573 putative substrate binding site [chemical binding]; other site 1246995004574 catalytic Zn binding site [ion binding]; other site 1246995004575 structural Zn binding site [ion binding]; other site 1246995004576 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995004577 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995004578 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1246995004579 S-adenosylmethionine binding site [chemical binding]; other site 1246995004580 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1246995004581 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1246995004582 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 1246995004583 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1246995004584 Family description; Region: UvrD_C_2; pfam13538 1246995004585 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1246995004586 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1246995004587 Serine hydrolase; Region: Ser_hydrolase; cl17834 1246995004588 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 1246995004589 active site clefts [active] 1246995004590 zinc binding site [ion binding]; other site 1246995004591 dimer interface [polypeptide binding]; other site 1246995004592 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 1246995004593 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1246995004594 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1246995004595 Cupin; Region: Cupin_6; pfam12852 1246995004596 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1246995004597 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1246995004598 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1246995004599 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1246995004600 putative NAD(P) binding site [chemical binding]; other site 1246995004601 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1246995004602 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1246995004603 dimer interface [polypeptide binding]; other site 1246995004604 active site 1246995004605 acyl carrier protein; Provisional; Region: acpP; PRK00982 1246995004606 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1246995004607 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1246995004608 dimer interface [polypeptide binding]; other site 1246995004609 active site 1246995004610 CoA binding pocket [chemical binding]; other site 1246995004611 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1246995004612 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1246995004613 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1246995004614 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995004615 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995004616 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1246995004617 DNA binding residues [nucleotide binding] 1246995004618 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1246995004619 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1246995004620 HIGH motif; other site 1246995004621 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1246995004622 active site 1246995004623 KMSKS motif; other site 1246995004624 Glyco_18 domain; Region: Glyco_18; smart00636 1246995004625 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 1246995004626 active site 1246995004627 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1246995004628 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1246995004629 putative sugar binding sites [chemical binding]; other site 1246995004630 Q-X-W motif; other site 1246995004631 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1246995004632 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1246995004633 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1246995004634 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 1246995004635 CGNR zinc finger; Region: zf-CGNR; pfam11706 1246995004636 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1246995004637 dimer interface [polypeptide binding]; other site 1246995004638 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1246995004639 putative CheW interface [polypeptide binding]; other site 1246995004640 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1246995004641 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1246995004642 dimer interface [polypeptide binding]; other site 1246995004643 TPP-binding site [chemical binding]; other site 1246995004644 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 1246995004645 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1246995004646 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1246995004647 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1246995004648 Walker A/P-loop; other site 1246995004649 ATP binding site [chemical binding]; other site 1246995004650 Q-loop/lid; other site 1246995004651 ABC transporter signature motif; other site 1246995004652 Walker B; other site 1246995004653 D-loop; other site 1246995004654 H-loop/switch region; other site 1246995004655 MarR family; Region: MarR_2; pfam12802 1246995004656 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1246995004657 TPP-binding site [chemical binding]; other site 1246995004658 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1246995004659 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 1246995004660 PYR/PP interface [polypeptide binding]; other site 1246995004661 dimer interface [polypeptide binding]; other site 1246995004662 TPP binding site [chemical binding]; other site 1246995004663 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1246995004664 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 1246995004665 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1246995004666 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 1246995004667 dimer interface [polypeptide binding]; other site 1246995004668 catalytic triad [active] 1246995004669 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1246995004670 S-adenosylmethionine binding site [chemical binding]; other site 1246995004671 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12859 1246995004672 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995004673 NAD(P) binding site [chemical binding]; other site 1246995004674 active site 1246995004675 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048 1246995004676 RNAase interaction site [polypeptide binding]; other site 1246995004677 Protein of unknown function (DUF402); Region: DUF402; pfam04167 1246995004678 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1246995004679 TIGR02569 family protein; Region: TIGR02569_actnb 1246995004680 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1246995004681 nudix motif; other site 1246995004682 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1246995004683 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1246995004684 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1246995004685 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1246995004686 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1246995004687 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1246995004688 non-specific DNA binding site [nucleotide binding]; other site 1246995004689 salt bridge; other site 1246995004690 sequence-specific DNA binding site [nucleotide binding]; other site 1246995004691 Cupin domain; Region: Cupin_2; pfam07883 1246995004692 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1246995004693 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1246995004694 S-adenosylmethionine binding site [chemical binding]; other site 1246995004695 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1246995004696 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1246995004697 Coenzyme A binding pocket [chemical binding]; other site 1246995004698 Bifunctional DNA primase/polymerase, N-terminal; Region: Prim-Pol; smart00943 1246995004699 nucleotide binding site [chemical binding]; other site 1246995004700 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1246995004701 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1246995004702 non-specific DNA binding site [nucleotide binding]; other site 1246995004703 salt bridge; other site 1246995004704 sequence-specific DNA binding site [nucleotide binding]; other site 1246995004705 Flavoprotein; Region: Flavoprotein; pfam02441 1246995004706 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1246995004707 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1246995004708 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 1246995004709 Putative zinc ribbon domain; Region: DUF164; pfam02591 1246995004710 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 1246995004711 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1246995004712 RNA/DNA hybrid binding site [nucleotide binding]; other site 1246995004713 active site 1246995004714 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1246995004715 catalytic core [active] 1246995004716 Glyco_18 domain; Region: Glyco_18; smart00636 1246995004717 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 1246995004718 active site 1246995004719 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 1246995004720 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 1246995004721 Na binding site [ion binding]; other site 1246995004722 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1246995004723 MarR family; Region: MarR; pfam01047 1246995004724 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1246995004725 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 1246995004726 Uncharacterized conserved protein [Function unknown]; Region: COG4278 1246995004727 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995004728 active site 1246995004729 phosphorylation site [posttranslational modification] 1246995004730 intermolecular recognition site; other site 1246995004731 dimerization interface [polypeptide binding]; other site 1246995004732 MASE1; Region: MASE1; cl17823 1246995004733 PAS domain; Region: PAS; smart00091 1246995004734 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1246995004735 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1246995004736 dimer interface [polypeptide binding]; other site 1246995004737 phosphorylation site [posttranslational modification] 1246995004738 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995004739 ATP binding site [chemical binding]; other site 1246995004740 Mg2+ binding site [ion binding]; other site 1246995004741 G-X-G motif; other site 1246995004742 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1246995004743 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 1246995004744 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1246995004745 threonine dehydratase; Provisional; Region: PRK08246 1246995004746 hypothetical protein; Provisional; Region: PRK06815 1246995004747 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1246995004748 catalytic residue [active] 1246995004749 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1246995004750 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1246995004751 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1246995004752 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436 1246995004753 putative dimerization interface [polypeptide binding]; other site 1246995004754 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1246995004755 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1246995004756 dimerization interface [polypeptide binding]; other site 1246995004757 active site 1246995004758 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1246995004759 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1246995004760 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1246995004761 S-adenosylmethionine binding site [chemical binding]; other site 1246995004762 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1246995004763 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1246995004764 RNB domain; Region: RNB; pfam00773 1246995004765 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1246995004766 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 1246995004767 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1246995004768 oligomerization interface [polypeptide binding]; other site 1246995004769 active site 1246995004770 metal binding site [ion binding]; metal-binding site 1246995004771 NAD synthetase; Provisional; Region: PRK13981 1246995004772 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 1246995004773 multimer interface [polypeptide binding]; other site 1246995004774 active site 1246995004775 catalytic triad [active] 1246995004776 protein interface 1 [polypeptide binding]; other site 1246995004777 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1246995004778 homodimer interface [polypeptide binding]; other site 1246995004779 NAD binding pocket [chemical binding]; other site 1246995004780 ATP binding pocket [chemical binding]; other site 1246995004781 Mg binding site [ion binding]; other site 1246995004782 active-site loop [active] 1246995004783 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1246995004784 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1246995004785 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1246995004786 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1246995004787 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1246995004788 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 1246995004789 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1246995004790 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1246995004791 Coenzyme A binding pocket [chemical binding]; other site 1246995004792 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1246995004793 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1246995004794 catalytic triad [active] 1246995004795 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 1246995004796 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1246995004797 metal binding triad; other site 1246995004798 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1246995004799 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1246995004800 metal binding triad; other site 1246995004801 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1246995004802 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1246995004803 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1246995004804 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1246995004805 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1246995004806 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 1246995004807 Chondroitin sulphate attachment domain; Region: Chon_Sulph_att; pfam06566 1246995004808 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 1246995004809 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1246995004810 AAA ATPase domain; Region: AAA_16; pfam13191 1246995004811 Predicted ATPase [General function prediction only]; Region: COG3903 1246995004812 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1246995004813 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1246995004814 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1246995004815 RDD family; Region: RDD; pfam06271 1246995004816 glutamine synthetase, type I; Region: GlnA; TIGR00653 1246995004817 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1246995004818 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1246995004819 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1246995004820 active site 1246995004821 DNA binding site [nucleotide binding] 1246995004822 Int/Topo IB signature motif; other site 1246995004823 Helix-turn-helix domain; Region: HTH_17; pfam12728 1246995004824 TIR domain; Region: TIR_2; pfam13676 1246995004825 NB-ARC domain; Region: NB-ARC; pfam00931 1246995004826 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1246995004827 Tetratricopeptide repeat; Region: TPR_10; pfam13374 1246995004828 Uncharacterized conserved protein [Function unknown]; Region: COG1479 1246995004829 Protein of unknown function DUF262; Region: DUF262; pfam03235 1246995004830 Uncharacterized conserved protein [Function unknown]; Region: COG3472 1246995004831 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 1246995004832 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1246995004833 active site 1246995004834 Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206 1246995004835 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 1246995004836 active site 1246995004837 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 1246995004838 Protein of unknown function (DUF998); Region: DUF998; pfam06197 1246995004839 YCII-related domain; Region: YCII; cl00999 1246995004840 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 1246995004841 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995004842 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1246995004843 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 1246995004844 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1246995004845 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1246995004846 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995004847 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995004848 WHG domain; Region: WHG; pfam13305 1246995004849 Domain of unknown function (DUF1772); Region: DUF1772; pfam08592 1246995004850 lipoyl synthase; Provisional; Region: PRK05481 1246995004851 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1246995004852 FeS/SAM binding site; other site 1246995004853 aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159 1246995004854 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 1246995004855 Dimer interface [polypeptide binding]; other site 1246995004856 anticodon binding site; other site 1246995004857 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1246995004858 motif 1; other site 1246995004859 dimer interface [polypeptide binding]; other site 1246995004860 active site 1246995004861 motif 2; other site 1246995004862 motif 3; other site 1246995004863 Predicted membrane protein [General function prediction only]; Region: COG4194 1246995004864 lipoate-protein ligase B; Provisional; Region: PRK14345 1246995004865 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995004866 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1246995004867 NAD(P) binding site [chemical binding]; other site 1246995004868 active site 1246995004869 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1246995004870 E3 interaction surface; other site 1246995004871 lipoyl attachment site [posttranslational modification]; other site 1246995004872 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1246995004873 E3 interaction surface; other site 1246995004874 lipoyl attachment site [posttranslational modification]; other site 1246995004875 e3 binding domain; Region: E3_binding; pfam02817 1246995004876 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 1246995004877 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1246995004878 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1246995004879 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1246995004880 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1246995004881 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1246995004882 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1246995004883 interface (dimer of trimers) [polypeptide binding]; other site 1246995004884 Substrate-binding/catalytic site; other site 1246995004885 Zn-binding sites [ion binding]; other site 1246995004886 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1246995004887 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1246995004888 cobalamin synthase; Reviewed; Region: cobS; PRK00235 1246995004889 Cobinamide kinase / cobinamide phosphate guanyltransferase; Region: CobU; pfam02283 1246995004890 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cl11435 1246995004891 active site pocket [active] 1246995004892 putative cataytic base [active] 1246995004893 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 1246995004894 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 1246995004895 Peptidase family M50; Region: Peptidase_M50; pfam02163 1246995004896 active site 1246995004897 putative substrate binding region [chemical binding]; other site 1246995004898 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1246995004899 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1246995004900 active site 1246995004901 catalytic tetrad [active] 1246995004902 Protein of unknown function (DUF2816); Region: DUF2816; pfam10992 1246995004903 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1246995004904 TPR motif; other site 1246995004905 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1246995004906 binding surface 1246995004907 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 1246995004908 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 1246995004909 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 1246995004910 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995004911 Walker A/P-loop; other site 1246995004912 ATP binding site [chemical binding]; other site 1246995004913 Q-loop/lid; other site 1246995004914 ABC transporter signature motif; other site 1246995004915 Walker B; other site 1246995004916 D-loop; other site 1246995004917 H-loop/switch region; other site 1246995004918 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1246995004919 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1246995004920 non-specific DNA binding site [nucleotide binding]; other site 1246995004921 salt bridge; other site 1246995004922 sequence-specific DNA binding site [nucleotide binding]; other site 1246995004923 Cupin domain; Region: Cupin_2; pfam07883 1246995004924 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1246995004925 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 1246995004926 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 1246995004927 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1246995004928 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1246995004929 hinge; other site 1246995004930 active site 1246995004931 quinolinate synthetase; Provisional; Region: PRK09375 1246995004932 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1246995004933 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 1246995004934 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 1246995004935 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1246995004936 substrate binding site [chemical binding]; other site 1246995004937 ATP binding site [chemical binding]; other site 1246995004938 AAA domain; Region: AAA_33; pfam13671 1246995004939 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1246995004940 CPxP motif; other site 1246995004941 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1246995004942 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1246995004943 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 1246995004944 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1246995004945 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 1246995004946 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1246995004947 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1246995004948 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1246995004949 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 1246995004950 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 1246995004951 Subunit I/III interface [polypeptide binding]; other site 1246995004952 Cytochrome c; Region: Cytochrom_C; cl11414 1246995004953 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1246995004954 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1246995004955 iron-sulfur cluster [ion binding]; other site 1246995004956 [2Fe-2S] cluster binding site [ion binding]; other site 1246995004957 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1246995004958 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 1246995004959 intrachain domain interface; other site 1246995004960 interchain domain interface [polypeptide binding]; other site 1246995004961 heme bL binding site [chemical binding]; other site 1246995004962 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 1246995004963 heme bH binding site [chemical binding]; other site 1246995004964 Qo binding site; other site 1246995004965 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1246995004966 AsnC family; Region: AsnC_trans_reg; pfam01037 1246995004967 Predicted transcriptional regulators [Transcription]; Region: COG1695 1246995004968 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1246995004969 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 1246995004970 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1246995004971 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1246995004972 active site 1246995004973 NUDIX domain; Region: NUDIX; pfam00293 1246995004974 nudix motif; other site 1246995004975 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1246995004976 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1246995004977 Zn2+ binding site [ion binding]; other site 1246995004978 Mg2+ binding site [ion binding]; other site 1246995004979 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1246995004980 synthetase active site [active] 1246995004981 NTP binding site [chemical binding]; other site 1246995004982 metal binding site [ion binding]; metal-binding site 1246995004983 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1246995004984 hypothetical protein; Validated; Region: PRK07883 1246995004985 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1246995004986 active site 1246995004987 catalytic site [active] 1246995004988 substrate binding site [chemical binding]; other site 1246995004989 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1246995004990 GIY-YIG motif/motif A; other site 1246995004991 active site 1246995004992 catalytic site [active] 1246995004993 putative DNA binding site [nucleotide binding]; other site 1246995004994 metal binding site [ion binding]; metal-binding site 1246995004995 YacP-like NYN domain; Region: NYN_YacP; cl01491 1246995004996 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1246995004997 Peptidase family M48; Region: Peptidase_M48; cl12018 1246995004998 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1246995004999 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1246995005000 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995005001 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1246995005002 Walker A/P-loop; other site 1246995005003 ATP binding site [chemical binding]; other site 1246995005004 Q-loop/lid; other site 1246995005005 ABC transporter signature motif; other site 1246995005006 Walker B; other site 1246995005007 D-loop; other site 1246995005008 H-loop/switch region; other site 1246995005009 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1246995005010 catalytic residues [active] 1246995005011 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1246995005012 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995005013 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1246995005014 DNA binding residues [nucleotide binding] 1246995005015 anti-sigma factor, putative, ChrR family; Region: anti_sig_ChrR; TIGR02451 1246995005016 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 1246995005017 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1246995005018 Walker A/P-loop; other site 1246995005019 ATP binding site [chemical binding]; other site 1246995005020 Q-loop/lid; other site 1246995005021 ABC transporter signature motif; other site 1246995005022 Walker B; other site 1246995005023 D-loop; other site 1246995005024 H-loop/switch region; other site 1246995005025 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 1246995005026 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995005027 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995005028 active site 1246995005029 phosphorylation site [posttranslational modification] 1246995005030 intermolecular recognition site; other site 1246995005031 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995005032 DNA binding residues [nucleotide binding] 1246995005033 dimerization interface [polypeptide binding]; other site 1246995005034 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1246995005035 Histidine kinase; Region: HisKA_3; pfam07730 1246995005036 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995005037 ATP binding site [chemical binding]; other site 1246995005038 Mg2+ binding site [ion binding]; other site 1246995005039 G-X-G motif; other site 1246995005040 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1246995005041 putative hydrophobic ligand binding site [chemical binding]; other site 1246995005042 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1246995005043 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1246995005044 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1246995005045 putative metal binding site [ion binding]; other site 1246995005046 putative catalytic site [active] 1246995005047 putative phosphate binding site [ion binding]; other site 1246995005048 putative metal binding site [ion binding]; other site 1246995005049 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1246995005050 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1246995005051 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 1246995005052 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1246995005053 active site 1246995005054 homotetramer interface [polypeptide binding]; other site 1246995005055 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1246995005056 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1246995005057 putative acyl-acceptor binding pocket; other site 1246995005058 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1246995005059 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1246995005060 ligand binding site [chemical binding]; other site 1246995005061 flexible hinge region; other site 1246995005062 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1246995005063 Phosphotransferase enzyme family; Region: APH; pfam01636 1246995005064 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1246995005065 active site 1246995005066 ATP binding site [chemical binding]; other site 1246995005067 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1246995005068 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 1246995005069 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1246995005070 putative NAD(P) binding site [chemical binding]; other site 1246995005071 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995005072 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1246995005073 phosphofructokinase; Region: PFK_mixed; TIGR02483 1246995005074 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1246995005075 active site 1246995005076 ADP/pyrophosphate binding site [chemical binding]; other site 1246995005077 dimerization interface [polypeptide binding]; other site 1246995005078 allosteric effector site; other site 1246995005079 fructose-1,6-bisphosphate binding site; other site 1246995005080 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1246995005081 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1246995005082 Protein of unknown function (DUF429); Region: DUF429; cl12046 1246995005083 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1246995005084 catalytic residues [active] 1246995005085 dimer interface [polypeptide binding]; other site 1246995005086 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 1246995005087 aromatic chitin/cellulose binding site residues [chemical binding]; other site 1246995005088 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 1246995005089 Glyco_18 domain; Region: Glyco_18; smart00636 1246995005090 active site 1246995005091 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 1246995005092 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 1246995005093 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 1246995005094 tetramer interface [polypeptide binding]; other site 1246995005095 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1246995005096 catalytic residue [active] 1246995005097 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995005098 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995005099 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1246995005100 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1246995005101 putative NAD(P) binding site [chemical binding]; other site 1246995005102 Protein of unknown function (DUF3224); Region: DUF3224; pfam11528 1246995005103 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1246995005104 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1246995005105 salt bridge; other site 1246995005106 non-specific DNA binding site [nucleotide binding]; other site 1246995005107 sequence-specific DNA binding site [nucleotide binding]; other site 1246995005108 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 1246995005109 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1246995005110 AP endonuclease family 2; Region: AP2Ec; smart00518 1246995005111 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1246995005112 AP (apurinic/apyrimidinic) site pocket; other site 1246995005113 DNA interaction; other site 1246995005114 Metal-binding active site; metal-binding site 1246995005115 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1246995005116 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1246995005117 active site 1246995005118 ATP binding site [chemical binding]; other site 1246995005119 substrate binding site [chemical binding]; other site 1246995005120 activation loop (A-loop); other site 1246995005121 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1246995005122 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1246995005123 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1246995005124 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1246995005125 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1246995005126 Helix-turn-helix domain; Region: HTH_17; pfam12728 1246995005127 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 1246995005128 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 1246995005129 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1246995005130 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1246995005131 substrate binding pocket [chemical binding]; other site 1246995005132 chain length determination region; other site 1246995005133 substrate-Mg2+ binding site; other site 1246995005134 catalytic residues [active] 1246995005135 aspartate-rich region 1; other site 1246995005136 active site lid residues [active] 1246995005137 aspartate-rich region 2; other site 1246995005138 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1246995005139 FAD binding site [chemical binding]; other site 1246995005140 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1246995005141 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1246995005142 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1246995005143 active site 1246995005144 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1246995005145 active site 1246995005146 catalytic site [active] 1246995005147 substrate binding site [chemical binding]; other site 1246995005148 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1246995005149 Dimer interface [polypeptide binding]; other site 1246995005150 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1246995005151 MarR family; Region: MarR_2; pfam12802 1246995005152 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1246995005153 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1246995005154 putative substrate translocation pore; other site 1246995005155 H+ Antiporter protein; Region: 2A0121; TIGR00900 1246995005156 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1246995005157 hypothetical protein; Provisional; Region: PRK06184 1246995005158 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1246995005159 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1246995005160 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995005161 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995005162 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 1246995005163 Cadmium resistance transporter; Region: Cad; pfam03596 1246995005164 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1246995005165 active site 1246995005166 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1246995005167 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 1246995005168 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1246995005169 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1246995005170 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 1246995005171 L-aspartate oxidase; Provisional; Region: PRK06175 1246995005172 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1246995005173 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 1246995005174 proximal heme binding site [chemical binding]; other site 1246995005175 distal heme binding site [chemical binding]; other site 1246995005176 putative dimer interface [polypeptide binding]; other site 1246995005177 putative Iron-sulfur protein interface [polypeptide binding]; other site 1246995005178 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1246995005179 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1246995005180 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1246995005181 dimerization interface [polypeptide binding]; other site 1246995005182 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1246995005183 putative active site [active] 1246995005184 catalytic site [active] 1246995005185 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1246995005186 putative active site [active] 1246995005187 catalytic site [active] 1246995005188 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995005189 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1246995005190 NAD(P) binding site [chemical binding]; other site 1246995005191 active site 1246995005192 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1246995005193 MarR family; Region: MarR; pfam01047 1246995005194 phytoene desaturase; Region: crtI_fam; TIGR02734 1246995005195 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 1246995005196 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1246995005197 active site 1246995005198 Protein of unknown function (DUF422); Region: DUF422; cl00991 1246995005199 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1246995005200 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1246995005201 Domain of unknown function (DUF4188); Region: DUF4188; pfam13826 1246995005202 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 1246995005203 putative deacylase active site [active] 1246995005204 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 1246995005205 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1246995005206 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 1246995005207 FAD binding pocket [chemical binding]; other site 1246995005208 FAD binding motif [chemical binding]; other site 1246995005209 phosphate binding motif [ion binding]; other site 1246995005210 beta-alpha-beta structure motif; other site 1246995005211 NAD binding pocket [chemical binding]; other site 1246995005212 EamA-like transporter family; Region: EamA; pfam00892 1246995005213 EamA-like transporter family; Region: EamA; pfam00892 1246995005214 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1246995005215 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995005216 NAD(P) binding site [chemical binding]; other site 1246995005217 active site 1246995005218 DNA Polymerase Y-family; Region: PolY_like; cd03468 1246995005219 DNA binding site [nucleotide binding] 1246995005220 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 1246995005221 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1246995005222 active site 1246995005223 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1246995005224 generic binding surface II; other site 1246995005225 generic binding surface I; other site 1246995005226 Subtilisin inhibitor-like; Region: SSI; cl11594 1246995005227 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1246995005228 active site 1246995005229 catalytic residues [active] 1246995005230 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1246995005231 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 1246995005232 Uncharacterized conserved protein [Function unknown]; Region: COG3379 1246995005233 DNA polymerase IV; Validated; Region: PRK02406 1246995005234 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1246995005235 active site 1246995005236 DNA binding site [nucleotide binding] 1246995005237 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 1246995005238 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1246995005239 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1246995005240 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1246995005241 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1246995005242 Protein of unknown function DUF58; Region: DUF58; pfam01882 1246995005243 MoxR-like ATPases [General function prediction only]; Region: COG0714 1246995005244 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1246995005245 Walker A motif; other site 1246995005246 ATP binding site [chemical binding]; other site 1246995005247 Walker B motif; other site 1246995005248 arginine finger; other site 1246995005249 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1246995005250 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1246995005251 HIGH motif; other site 1246995005252 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1246995005253 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1246995005254 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1246995005255 active site 1246995005256 KMSKS motif; other site 1246995005257 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1246995005258 tRNA binding surface [nucleotide binding]; other site 1246995005259 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1246995005260 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1246995005261 hinge; other site 1246995005262 active site 1246995005263 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1246995005264 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1246995005265 catalytic triad [active] 1246995005266 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1246995005267 LIM is a small protein-protein interaction domain, containing two zinc fingers; Region: LIM; cl02475 1246995005268 Zn binding site [ion binding]; other site 1246995005269 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1246995005270 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1246995005271 NlpC/P60 family; Region: NLPC_P60; cl17555 1246995005272 cell division protein MraZ; Reviewed; Region: PRK00326 1246995005273 MraZ protein; Region: MraZ; pfam02381 1246995005274 MraZ protein; Region: MraZ; pfam02381 1246995005275 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1246995005276 MraW methylase family; Region: Methyltransf_5; cl17771 1246995005277 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1246995005278 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1246995005279 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1246995005280 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1246995005281 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1246995005282 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1246995005283 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1246995005284 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1246995005285 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1246995005286 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1246995005287 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1246995005288 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1246995005289 Mg++ binding site [ion binding]; other site 1246995005290 putative catalytic motif [active] 1246995005291 putative substrate binding site [chemical binding]; other site 1246995005292 cell division protein FtsW; Region: ftsW; TIGR02614 1246995005293 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1246995005294 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1246995005295 active site 1246995005296 homodimer interface [polypeptide binding]; other site 1246995005297 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1246995005298 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1246995005299 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1246995005300 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1246995005301 Cell division protein FtsQ; Region: FtsQ; pfam03799 1246995005302 cell division protein FtsZ; Validated; Region: PRK09330 1246995005303 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1246995005304 nucleotide binding site [chemical binding]; other site 1246995005305 SulA interaction site; other site 1246995005306 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1246995005307 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1246995005308 catalytic residue [active] 1246995005309 Protein of unknown function (DUF552); Region: DUF552; pfam04472 1246995005310 DivIVA protein; Region: DivIVA; pfam05103 1246995005311 DivIVA domain; Region: DivI1A_domain; TIGR03544 1246995005312 Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594 1246995005313 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1246995005314 TrkA-C domain; Region: TrkA_C; pfam02080 1246995005315 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 1246995005316 lipoprotein signal peptidase; Provisional; Region: PRK14764 1246995005317 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 1246995005318 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1246995005319 RNA binding surface [nucleotide binding]; other site 1246995005320 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1246995005321 active site 1246995005322 AAA domain; Region: AAA_31; pfam13614 1246995005323 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1246995005324 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1246995005325 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 1246995005326 active site 1246995005327 PHP Thumb interface [polypeptide binding]; other site 1246995005328 metal binding site [ion binding]; metal-binding site 1246995005329 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1246995005330 generic binding surface II; other site 1246995005331 generic binding surface I; other site 1246995005332 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 1246995005333 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 1246995005334 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1246995005335 NAD binding site [chemical binding]; other site 1246995005336 dimerization interface [polypeptide binding]; other site 1246995005337 product binding site; other site 1246995005338 substrate binding site [chemical binding]; other site 1246995005339 zinc binding site [ion binding]; other site 1246995005340 catalytic residues [active] 1246995005341 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 1246995005342 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1246995005343 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1246995005344 homodimer interface [polypeptide binding]; other site 1246995005345 catalytic residue [active] 1246995005346 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1246995005347 putative active site pocket [active] 1246995005348 4-fold oligomerization interface [polypeptide binding]; other site 1246995005349 metal binding residues [ion binding]; metal-binding site 1246995005350 3-fold/trimer interface [polypeptide binding]; other site 1246995005351 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 1246995005352 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1246995005353 putative active site [active] 1246995005354 oxyanion strand; other site 1246995005355 catalytic triad [active] 1246995005356 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1246995005357 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1246995005358 catalytic residues [active] 1246995005359 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 1246995005360 homotrimer interaction site [polypeptide binding]; other site 1246995005361 putative active site [active] 1246995005362 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1246995005363 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1246995005364 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 1246995005365 putative dimerization interface [polypeptide binding]; other site 1246995005366 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1246995005367 EamA-like transporter family; Region: EamA; pfam00892 1246995005368 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1246995005369 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1246995005370 substrate binding site [chemical binding]; other site 1246995005371 glutamase interaction surface [polypeptide binding]; other site 1246995005372 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1246995005373 Predicted membrane protein [Function unknown]; Region: COG2364 1246995005374 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1246995005375 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1246995005376 DNA-binding site [nucleotide binding]; DNA binding site 1246995005377 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1246995005378 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1246995005379 homodimer interface [polypeptide binding]; other site 1246995005380 catalytic residue [active] 1246995005381 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1246995005382 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959 1246995005383 NodB motif; other site 1246995005384 putative active site [active] 1246995005385 putative catalytic site [active] 1246995005386 putative Zn binding site [ion binding]; other site 1246995005387 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1246995005388 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1246995005389 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 1246995005390 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995005391 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1246995005392 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1246995005393 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1246995005394 acyl-activating enzyme (AAE) consensus motif; other site 1246995005395 putative AMP binding site [chemical binding]; other site 1246995005396 putative active site [active] 1246995005397 putative CoA binding site [chemical binding]; other site 1246995005398 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1246995005399 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1246995005400 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 1246995005401 calcium binding site 2 [ion binding]; other site 1246995005402 active site 1246995005403 catalytic triad [active] 1246995005404 calcium binding site 1 [ion binding]; other site 1246995005405 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1246995005406 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1246995005407 S-adenosylmethionine binding site [chemical binding]; other site 1246995005408 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1246995005409 dimer interface [polypeptide binding]; other site 1246995005410 phosphorylation site [posttranslational modification] 1246995005411 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1246995005412 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995005413 active site 1246995005414 phosphorylation site [posttranslational modification] 1246995005415 intermolecular recognition site; other site 1246995005416 dimerization interface [polypeptide binding]; other site 1246995005417 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1246995005418 DNA binding site [nucleotide binding] 1246995005419 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1246995005420 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1246995005421 DNA-binding site [nucleotide binding]; DNA binding site 1246995005422 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1246995005423 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1246995005424 homodimer interface [polypeptide binding]; other site 1246995005425 catalytic residue [active] 1246995005426 putative transporter; Provisional; Region: PRK11021 1246995005427 TIGR03085 family protein; Region: TIGR03085 1246995005428 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1246995005429 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1246995005430 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995005431 Walker A/P-loop; other site 1246995005432 ATP binding site [chemical binding]; other site 1246995005433 Q-loop/lid; other site 1246995005434 ABC transporter signature motif; other site 1246995005435 Walker B; other site 1246995005436 D-loop; other site 1246995005437 H-loop/switch region; other site 1246995005438 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1246995005439 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1246995005440 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995005441 Walker A/P-loop; other site 1246995005442 ATP binding site [chemical binding]; other site 1246995005443 Q-loop/lid; other site 1246995005444 ABC transporter signature motif; other site 1246995005445 Walker B; other site 1246995005446 D-loop; other site 1246995005447 H-loop/switch region; other site 1246995005448 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1246995005449 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1246995005450 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1246995005451 RNA binding surface [nucleotide binding]; other site 1246995005452 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 1246995005453 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995005454 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995005455 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1246995005456 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 1246995005457 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1246995005458 Walker A/P-loop; other site 1246995005459 ATP binding site [chemical binding]; other site 1246995005460 Q-loop/lid; other site 1246995005461 ABC transporter signature motif; other site 1246995005462 Walker B; other site 1246995005463 D-loop; other site 1246995005464 H-loop/switch region; other site 1246995005465 Herpesvirus latent membrane protein 1 (LMP1); Region: Herpes_LMP1; pfam05297 1246995005466 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1246995005467 anthranilate synthase component I; Provisional; Region: PRK13571 1246995005468 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1246995005469 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1246995005470 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; cl17850 1246995005471 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1246995005472 active site 1246995005473 ribulose/triose binding site [chemical binding]; other site 1246995005474 phosphate binding site [ion binding]; other site 1246995005475 substrate (anthranilate) binding pocket [chemical binding]; other site 1246995005476 product (indole) binding pocket [chemical binding]; other site 1246995005477 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1246995005478 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1246995005479 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1246995005480 catalytic residue [active] 1246995005481 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1246995005482 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1246995005483 substrate binding site [chemical binding]; other site 1246995005484 active site 1246995005485 catalytic residues [active] 1246995005486 heterodimer interface [polypeptide binding]; other site 1246995005487 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1246995005488 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1246995005489 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1246995005490 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1246995005491 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1246995005492 active site 1246995005493 dimer interface [polypeptide binding]; other site 1246995005494 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1246995005495 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1246995005496 active site 1246995005497 FMN binding site [chemical binding]; other site 1246995005498 substrate binding site [chemical binding]; other site 1246995005499 3Fe-4S cluster binding site [ion binding]; other site 1246995005500 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1246995005501 domain interface; other site 1246995005502 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 1246995005503 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1246995005504 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1246995005505 metal ion-dependent adhesion site (MIDAS); other site 1246995005506 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 1246995005507 pyruvate kinase; Provisional; Region: PRK06247 1246995005508 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1246995005509 domain interfaces; other site 1246995005510 active site 1246995005511 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 1246995005512 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1246995005513 active site 1246995005514 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1246995005515 catalytic triad [active] 1246995005516 dimer interface [polypeptide binding]; other site 1246995005517 Short repeat of unknown function (DUF308); Region: DUF308; pfam03729 1246995005518 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 1246995005519 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995005520 active site 1246995005521 phosphorylation site [posttranslational modification] 1246995005522 intermolecular recognition site; other site 1246995005523 dimerization interface [polypeptide binding]; other site 1246995005524 ANTAR domain; Region: ANTAR; pfam03861 1246995005525 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1246995005526 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1246995005527 dimerization interface [polypeptide binding]; other site 1246995005528 ligand binding site [chemical binding]; other site 1246995005529 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1246995005530 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1246995005531 TM-ABC transporter signature motif; other site 1246995005532 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1246995005533 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1246995005534 TM-ABC transporter signature motif; other site 1246995005535 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1246995005536 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1246995005537 Walker A/P-loop; other site 1246995005538 ATP binding site [chemical binding]; other site 1246995005539 Q-loop/lid; other site 1246995005540 ABC transporter signature motif; other site 1246995005541 Walker B; other site 1246995005542 D-loop; other site 1246995005543 H-loop/switch region; other site 1246995005544 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1246995005545 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1246995005546 Walker A/P-loop; other site 1246995005547 ATP binding site [chemical binding]; other site 1246995005548 Q-loop/lid; other site 1246995005549 ABC transporter signature motif; other site 1246995005550 Walker B; other site 1246995005551 D-loop; other site 1246995005552 H-loop/switch region; other site 1246995005553 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1246995005554 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1246995005555 substrate binding pocket [chemical binding]; other site 1246995005556 membrane-bound complex binding site; other site 1246995005557 hinge residues; other site 1246995005558 amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; Region: HEQRo_perm_3TM; TIGR01726 1246995005559 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995005560 ABC-ATPase subunit interface; other site 1246995005561 Microsomal signal peptidase 25 kDa subunit (SPC25); Region: SPC25; pfam06703 1246995005562 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1246995005563 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1246995005564 Walker A/P-loop; other site 1246995005565 ATP binding site [chemical binding]; other site 1246995005566 Q-loop/lid; other site 1246995005567 ABC transporter signature motif; other site 1246995005568 Walker B; other site 1246995005569 D-loop; other site 1246995005570 H-loop/switch region; other site 1246995005571 DNA polymerase I; Provisional; Region: PRK05755 1246995005572 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1246995005573 active site 1246995005574 metal binding site 1 [ion binding]; metal-binding site 1246995005575 putative 5' ssDNA interaction site; other site 1246995005576 metal binding site 3; metal-binding site 1246995005577 metal binding site 2 [ion binding]; metal-binding site 1246995005578 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1246995005579 putative DNA binding site [nucleotide binding]; other site 1246995005580 putative metal binding site [ion binding]; other site 1246995005581 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1246995005582 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1246995005583 active site 1246995005584 DNA binding site [nucleotide binding] 1246995005585 catalytic site [active] 1246995005586 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1246995005587 dimerization interface [polypeptide binding]; other site 1246995005588 putative DNA binding site [nucleotide binding]; other site 1246995005589 putative Zn2+ binding site [ion binding]; other site 1246995005590 Protein of unknown function (DUF3140); Region: DUF3140; pfam11338 1246995005591 Protein of unknown function (DUF2945); Region: DUF2945; pfam11160 1246995005592 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1246995005593 S-adenosylmethionine binding site [chemical binding]; other site 1246995005594 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 1246995005595 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1246995005596 RNA binding site [nucleotide binding]; other site 1246995005597 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1246995005598 RNA binding site [nucleotide binding]; other site 1246995005599 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1246995005600 RNA binding site [nucleotide binding]; other site 1246995005601 S1 RNA binding domain; Region: S1; pfam00575 1246995005602 RNA binding site [nucleotide binding]; other site 1246995005603 dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333 1246995005604 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1246995005605 CoA-binding site [chemical binding]; other site 1246995005606 ATP-binding [chemical binding]; other site 1246995005607 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 1246995005608 excinuclease ABC subunit B; Provisional; Region: PRK05298 1246995005609 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1246995005610 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1246995005611 nucleotide binding region [chemical binding]; other site 1246995005612 ATP-binding site [chemical binding]; other site 1246995005613 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1246995005614 UvrB/uvrC motif; Region: UVR; pfam02151 1246995005615 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 1246995005616 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1246995005617 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1246995005618 Coenzyme A binding pocket [chemical binding]; other site 1246995005619 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 1246995005620 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 1246995005621 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1246995005622 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 1246995005623 G1 box; other site 1246995005624 putative GEF interaction site [polypeptide binding]; other site 1246995005625 GTP/Mg2+ binding site [chemical binding]; other site 1246995005626 Switch I region; other site 1246995005627 G2 box; other site 1246995005628 G3 box; other site 1246995005629 Switch II region; other site 1246995005630 G4 box; other site 1246995005631 G5 box; other site 1246995005632 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1246995005633 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1246995005634 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1246995005635 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1246995005636 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1246995005637 catalytic residue [active] 1246995005638 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1246995005639 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1246995005640 23S rRNA interface [nucleotide binding]; other site 1246995005641 L7/L12 interface [polypeptide binding]; other site 1246995005642 putative thiostrepton binding site; other site 1246995005643 L25 interface [polypeptide binding]; other site 1246995005644 Clp protease; Region: CLP_protease; pfam00574 1246995005645 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1246995005646 oligomer interface [polypeptide binding]; other site 1246995005647 active site residues [active] 1246995005648 Isochorismatase family; Region: Isochorismatase; pfam00857 1246995005649 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1246995005650 catalytic triad [active] 1246995005651 conserved cis-peptide bond; other site 1246995005652 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1246995005653 mycothiol-dependent maleylpyruvate isomerase; Reviewed; Region: PRK09583 1246995005654 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1246995005655 Predicted GTPases [General function prediction only]; Region: COG1162 1246995005656 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1246995005657 RNA binding site [nucleotide binding]; other site 1246995005658 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1246995005659 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1246995005660 GTP/Mg2+ binding site [chemical binding]; other site 1246995005661 G4 box; other site 1246995005662 G5 box; other site 1246995005663 G1 box; other site 1246995005664 Switch I region; other site 1246995005665 G2 box; other site 1246995005666 G3 box; other site 1246995005667 Switch II region; other site 1246995005668 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1246995005669 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1246995005670 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1246995005671 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1246995005672 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1246995005673 iron-sulfur cluster [ion binding]; other site 1246995005674 [2Fe-2S] cluster binding site [ion binding]; other site 1246995005675 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1246995005676 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1246995005677 GIY-YIG motif/motif A; other site 1246995005678 active site 1246995005679 catalytic site [active] 1246995005680 putative DNA binding site [nucleotide binding]; other site 1246995005681 metal binding site [ion binding]; metal-binding site 1246995005682 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1246995005683 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1246995005684 Helix-hairpin-helix motif; Region: HHH; pfam00633 1246995005685 helix-hairpin-helix signature motif; other site 1246995005686 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1246995005687 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1246995005688 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 1246995005689 phosphate binding site [ion binding]; other site 1246995005690 putative substrate binding pocket [chemical binding]; other site 1246995005691 dimer interface [polypeptide binding]; other site 1246995005692 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1246995005693 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1246995005694 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1246995005695 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1246995005696 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1246995005697 Phosphoglycerate kinase; Region: PGK; pfam00162 1246995005698 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1246995005699 substrate binding site [chemical binding]; other site 1246995005700 hinge regions; other site 1246995005701 ADP binding site [chemical binding]; other site 1246995005702 catalytic site [active] 1246995005703 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1246995005704 triosephosphate isomerase; Provisional; Region: PRK14567 1246995005705 substrate binding site [chemical binding]; other site 1246995005706 dimer interface [polypeptide binding]; other site 1246995005707 catalytic triad [active] 1246995005708 Preprotein translocase SecG subunit; Region: SecG; cl09123 1246995005709 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 1246995005710 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1246995005711 Coenzyme A binding pocket [chemical binding]; other site 1246995005712 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1246995005713 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1246995005714 DNA binding residues [nucleotide binding] 1246995005715 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 1246995005716 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1246995005717 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1246995005718 putative active site [active] 1246995005719 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 1246995005720 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 1246995005721 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1246995005722 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1246995005723 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1246995005724 bifunctional transaldolase/phosoglucose isomerase; Validated; Region: PRK09533 1246995005725 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 1246995005726 putative active site [active] 1246995005727 transaldolase; Provisional; Region: PRK03903 1246995005728 catalytic residue [active] 1246995005729 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1246995005730 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1246995005731 TPP-binding site [chemical binding]; other site 1246995005732 dimer interface [polypeptide binding]; other site 1246995005733 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1246995005734 PYR/PP interface [polypeptide binding]; other site 1246995005735 dimer interface [polypeptide binding]; other site 1246995005736 TPP binding site [chemical binding]; other site 1246995005737 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1246995005738 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1246995005739 UbiA prenyltransferase family; Region: UbiA; pfam01040 1246995005740 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1246995005741 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1246995005742 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1246995005743 putative DNA binding site [nucleotide binding]; other site 1246995005744 dimerization interface [polypeptide binding]; other site 1246995005745 Predicted transcriptional regulator [Transcription]; Region: COG2345 1246995005746 putative Zn2+ binding site [ion binding]; other site 1246995005747 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1246995005748 FeS assembly protein SufB; Region: sufB; TIGR01980 1246995005749 FeS assembly protein SufD; Region: sufD; TIGR01981 1246995005750 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 1246995005751 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 1246995005752 [2Fe-2S] cluster binding site [ion binding]; other site 1246995005753 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1246995005754 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1246995005755 Walker A/P-loop; other site 1246995005756 ATP binding site [chemical binding]; other site 1246995005757 Q-loop/lid; other site 1246995005758 ABC transporter signature motif; other site 1246995005759 Walker B; other site 1246995005760 D-loop; other site 1246995005761 H-loop/switch region; other site 1246995005762 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1246995005763 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1246995005764 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1246995005765 catalytic residue [active] 1246995005766 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1246995005767 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1246995005768 trimerization site [polypeptide binding]; other site 1246995005769 active site 1246995005770 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1246995005771 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1246995005772 classical (c) SDRs; Region: SDR_c; cd05233 1246995005773 NAD(P) binding site [chemical binding]; other site 1246995005774 active site 1246995005775 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1246995005776 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1246995005777 NAD(P) binding site [chemical binding]; other site 1246995005778 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1246995005779 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1246995005780 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1246995005781 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1246995005782 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1246995005783 Bacterial transcriptional regulator; Region: IclR; pfam01614 1246995005784 dihydroxy-acid dehydratase; Validated; Region: PRK06131 1246995005785 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1246995005786 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1246995005787 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1246995005788 catalytic core [active] 1246995005789 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 1246995005790 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 1246995005791 active site 1246995005792 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1246995005793 non-specific DNA binding site [nucleotide binding]; other site 1246995005794 salt bridge; other site 1246995005795 sequence-specific DNA binding site [nucleotide binding]; other site 1246995005796 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1246995005797 Helix-turn-helix domain; Region: HTH_31; pfam13560 1246995005798 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1246995005799 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1246995005800 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995005801 Walker A/P-loop; other site 1246995005802 ATP binding site [chemical binding]; other site 1246995005803 Q-loop/lid; other site 1246995005804 ABC transporter signature motif; other site 1246995005805 Walker B; other site 1246995005806 D-loop; other site 1246995005807 H-loop/switch region; other site 1246995005808 ABC transporter; Region: ABC_tran_2; pfam12848 1246995005809 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1246995005810 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1246995005811 trimer interface [polypeptide binding]; other site 1246995005812 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1246995005813 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1246995005814 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995005815 Walker A/P-loop; other site 1246995005816 ATP binding site [chemical binding]; other site 1246995005817 Q-loop/lid; other site 1246995005818 ABC transporter signature motif; other site 1246995005819 Walker B; other site 1246995005820 D-loop; other site 1246995005821 H-loop/switch region; other site 1246995005822 glycogen branching enzyme; Provisional; Region: PRK14705 1246995005823 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1246995005824 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1246995005825 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; cl17322 1246995005826 YCII-related domain; Region: YCII; cl00999 1246995005827 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 1246995005828 active site 1246995005829 catalytic residues [active] 1246995005830 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 1246995005831 putative hydrophobic ligand binding site [chemical binding]; other site 1246995005832 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1246995005833 dimerization interface [polypeptide binding]; other site 1246995005834 putative DNA binding site [nucleotide binding]; other site 1246995005835 putative Zn2+ binding site [ion binding]; other site 1246995005836 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Region: SET; smart00317 1246995005837 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 1246995005838 active site 1246995005839 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1246995005840 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1246995005841 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995005842 NAD(P) binding site [chemical binding]; other site 1246995005843 active site 1246995005844 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1246995005845 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1246995005846 non-specific DNA binding site [nucleotide binding]; other site 1246995005847 salt bridge; other site 1246995005848 sequence-specific DNA binding site [nucleotide binding]; other site 1246995005849 SnoaL-like domain; Region: SnoaL_2; pfam12680 1246995005850 Cupin domain; Region: Cupin_2; pfam07883 1246995005851 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1246995005852 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995005853 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1246995005854 NAD(P) binding site [chemical binding]; other site 1246995005855 active site 1246995005856 hypothetical protein; Provisional; Region: PRK05409 1246995005857 TIGR04222 domain; Region: near_uncomplex 1246995005858 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995005859 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995005860 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1246995005861 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1246995005862 motif II; other site 1246995005863 RIO kinase family, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside...; Region: RIO; cl17248 1246995005864 ATP binding site [chemical binding]; other site 1246995005865 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 1246995005866 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1246995005867 glutamine synthetase; Region: PLN02284 1246995005868 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1246995005869 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1246995005870 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1246995005871 DNA binding site [nucleotide binding] 1246995005872 aconitate hydratase; Validated; Region: PRK09277 1246995005873 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1246995005874 substrate binding site [chemical binding]; other site 1246995005875 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1246995005876 ligand binding site [chemical binding]; other site 1246995005877 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1246995005878 substrate binding site [chemical binding]; other site 1246995005879 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 1246995005880 carbohydrate binding site [chemical binding]; other site 1246995005881 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 1246995005882 carbohydrate binding site [chemical binding]; other site 1246995005883 alpha-1,6-glucosidases, pullulanase-type; Region: pullul_strch; TIGR02103 1246995005884 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 1246995005885 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 1246995005886 Ca binding site [ion binding]; other site 1246995005887 active site 1246995005888 catalytic site [active] 1246995005889 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 1246995005890 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995005891 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 1246995005892 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1246995005893 S-adenosylmethionine binding site [chemical binding]; other site 1246995005894 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995005895 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995005896 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1246995005897 hypothetical protein; Provisional; Region: PRK07588 1246995005898 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 1246995005899 proline aminopeptidase P II; Provisional; Region: PRK10879 1246995005900 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1246995005901 active site 1246995005902 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cl00891 1246995005903 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1246995005904 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1246995005905 putative substrate binding site [chemical binding]; other site 1246995005906 putative ATP binding site [chemical binding]; other site 1246995005907 Predicted thioesterase [General function prediction only]; Region: COG5496 1246995005908 Predicted membrane protein [Function unknown]; Region: COG3428 1246995005909 Bacterial PH domain; Region: DUF304; pfam03703 1246995005910 Bacterial PH domain; Region: DUF304; pfam03703 1246995005911 Bacterial PH domain; Region: DUF304; pfam03703 1246995005912 Uncharacterized conserved protein [Function unknown]; Region: COG3402 1246995005913 MoxR-like ATPases [General function prediction only]; Region: COG0714 1246995005914 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1246995005915 Walker A motif; other site 1246995005916 ATP binding site [chemical binding]; other site 1246995005917 Walker B motif; other site 1246995005918 arginine finger; other site 1246995005919 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1246995005920 Protein of unknown function DUF58; Region: DUF58; pfam01882 1246995005921 hypothetical protein; Provisional; Region: PRK13685 1246995005922 von Willebrand factor type A domain; Region: VWA_2; pfam13519 1246995005923 metal ion-dependent adhesion site (MIDAS); other site 1246995005924 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1246995005925 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741 1246995005926 nucleophilic elbow; other site 1246995005927 catalytic triad; other site 1246995005928 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995005929 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995005930 active site 1246995005931 phosphorylation site [posttranslational modification] 1246995005932 intermolecular recognition site; other site 1246995005933 dimerization interface [polypeptide binding]; other site 1246995005934 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995005935 DNA binding residues [nucleotide binding] 1246995005936 dimerization interface [polypeptide binding]; other site 1246995005937 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1246995005938 Histidine kinase; Region: HisKA_3; pfam07730 1246995005939 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1246995005940 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1246995005941 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1246995005942 NAD(P) binding site [chemical binding]; other site 1246995005943 homotetramer interface [polypeptide binding]; other site 1246995005944 homodimer interface [polypeptide binding]; other site 1246995005945 active site 1246995005946 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 1246995005947 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1246995005948 NAD binding site [chemical binding]; other site 1246995005949 homotetramer interface [polypeptide binding]; other site 1246995005950 homodimer interface [polypeptide binding]; other site 1246995005951 substrate binding site [chemical binding]; other site 1246995005952 active site 1246995005953 ferrochelatase; Reviewed; Region: hemH; PRK00035 1246995005954 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1246995005955 C-terminal domain interface [polypeptide binding]; other site 1246995005956 active site 1246995005957 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1246995005958 active site 1246995005959 N-terminal domain interface [polypeptide binding]; other site 1246995005960 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1246995005961 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1246995005962 active site 1246995005963 motif I; other site 1246995005964 motif II; other site 1246995005965 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1246995005966 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1246995005967 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1246995005968 nudix motif; other site 1246995005969 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1246995005970 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 1246995005971 dimerization interface [polypeptide binding]; other site 1246995005972 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1246995005973 dimer interface [polypeptide binding]; other site 1246995005974 putative CheW interface [polypeptide binding]; other site 1246995005975 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1246995005976 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1246995005977 salt bridge; other site 1246995005978 non-specific DNA binding site [nucleotide binding]; other site 1246995005979 sequence-specific DNA binding site [nucleotide binding]; other site 1246995005980 short chain dehydrogenase; Provisional; Region: PRK06482 1246995005981 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1246995005982 NADP binding site [chemical binding]; other site 1246995005983 active site 1246995005984 steroid binding site; other site 1246995005985 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1246995005986 nudix motif; other site 1246995005987 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 1246995005988 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1246995005989 putative DNA binding site [nucleotide binding]; other site 1246995005990 putative Zn2+ binding site [ion binding]; other site 1246995005991 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1246995005992 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1246995005993 tetramer interface [polypeptide binding]; other site 1246995005994 active site 1246995005995 Mg2+/Mn2+ binding site [ion binding]; other site 1246995005996 Beta-lactamase; Region: Beta-lactamase; pfam00144 1246995005997 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1246995005998 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 1246995005999 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1246995006000 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1246995006001 RibD C-terminal domain; Region: RibD_C; cl17279 1246995006002 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1246995006003 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1246995006004 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1246995006005 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1246995006006 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1246995006007 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1246995006008 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1246995006009 homodimer interface [polypeptide binding]; other site 1246995006010 catalytic residue [active] 1246995006011 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1246995006012 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 1246995006013 FAD binding pocket [chemical binding]; other site 1246995006014 conserved FAD binding motif [chemical binding]; other site 1246995006015 phosphate binding motif [ion binding]; other site 1246995006016 beta-alpha-beta structure motif; other site 1246995006017 NAD binding pocket [chemical binding]; other site 1246995006018 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1246995006019 putative catalytic site [active] 1246995006020 putative metal binding site [ion binding]; other site 1246995006021 putative phosphate binding site [ion binding]; other site 1246995006022 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK04690 1246995006023 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1246995006024 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1246995006025 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1246995006026 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1246995006027 putative active site [active] 1246995006028 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1246995006029 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1246995006030 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995006031 putative PBP binding loops; other site 1246995006032 dimer interface [polypeptide binding]; other site 1246995006033 ABC-ATPase subunit interface; other site 1246995006034 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1246995006035 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995006036 dimer interface [polypeptide binding]; other site 1246995006037 conserved gate region; other site 1246995006038 putative PBP binding loops; other site 1246995006039 ABC-ATPase subunit interface; other site 1246995006040 carbohydrate ABC transporter, N-acetylglucosamine/diacetylchitobiose-binding protein; Region: chitin_NgcE; TIGR03851 1246995006041 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1246995006042 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1246995006043 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995006044 putative PBP binding loops; other site 1246995006045 dimer interface [polypeptide binding]; other site 1246995006046 ABC-ATPase subunit interface; other site 1246995006047 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1246995006048 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995006049 dimer interface [polypeptide binding]; other site 1246995006050 conserved gate region; other site 1246995006051 putative PBP binding loops; other site 1246995006052 ABC-ATPase subunit interface; other site 1246995006053 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 1246995006054 putative hydrophobic ligand binding site [chemical binding]; other site 1246995006055 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1246995006056 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1246995006057 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1246995006058 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1246995006059 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995006060 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995006061 bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975 1246995006062 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cd06444 1246995006063 active site 1246995006064 DNA binding site [nucleotide binding] 1246995006065 catalytic site [active] 1246995006066 AAA ATPase domain; Region: AAA_16; pfam13191 1246995006067 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1246995006068 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1246995006069 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1246995006070 active site 1246995006071 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1246995006072 GAF domain; Region: GAF; pfam01590 1246995006073 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 1246995006074 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1246995006075 G2 box; other site 1246995006076 Switch I region; other site 1246995006077 G3 box; other site 1246995006078 Switch II region; other site 1246995006079 GTP/Mg2+ binding site [chemical binding]; other site 1246995006080 G4 box; other site 1246995006081 G5 box; other site 1246995006082 Protein of unknown function (DUF742); Region: DUF742; pfam05331 1246995006083 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 1246995006084 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995006085 ATP binding site [chemical binding]; other site 1246995006086 Mg2+ binding site [ion binding]; other site 1246995006087 G-X-G motif; other site 1246995006088 threonine synthase; Validated; Region: PRK08197 1246995006089 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1246995006090 homodimer interface [polypeptide binding]; other site 1246995006091 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1246995006092 catalytic residue [active] 1246995006093 TROVE domain; Region: TROVE; pfam05731 1246995006094 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1246995006095 metal ion-dependent adhesion site (MIDAS); other site 1246995006096 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 1246995006097 SnoaL-like domain; Region: SnoaL_3; pfam13474 1246995006098 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 1246995006099 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1246995006100 2TM domain; Region: 2TM; pfam13239 1246995006101 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1246995006102 Histidine kinase; Region: HisKA_3; pfam07730 1246995006103 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1246995006104 ATP binding site [chemical binding]; other site 1246995006105 Mg2+ binding site [ion binding]; other site 1246995006106 G-X-G motif; other site 1246995006107 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995006108 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995006109 active site 1246995006110 phosphorylation site [posttranslational modification] 1246995006111 intermolecular recognition site; other site 1246995006112 dimerization interface [polypeptide binding]; other site 1246995006113 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995006114 DNA binding residues [nucleotide binding] 1246995006115 dimerization interface [polypeptide binding]; other site 1246995006116 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1246995006117 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1246995006118 dimerization interface [polypeptide binding]; other site 1246995006119 substrate binding pocket [chemical binding]; other site 1246995006120 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 1246995006121 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 1246995006122 nudix motif; other site 1246995006123 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1246995006124 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1246995006125 putative DNA binding site [nucleotide binding]; other site 1246995006126 putative Zn2+ binding site [ion binding]; other site 1246995006127 short chain dehydrogenase; Provisional; Region: PRK06523 1246995006128 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995006129 NAD(P) binding site [chemical binding]; other site 1246995006130 active site 1246995006131 SnoaL-like domain; Region: SnoaL_2; pfam12680 1246995006132 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 1246995006133 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1246995006134 DNA binding residues [nucleotide binding] 1246995006135 drug binding residues [chemical binding]; other site 1246995006136 dimer interface [polypeptide binding]; other site 1246995006137 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 1246995006138 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1246995006139 Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200 1246995006140 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1246995006141 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1246995006142 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1246995006143 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1246995006144 active site 1246995006145 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 1246995006146 catalytic residues [active] 1246995006147 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1246995006148 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1246995006149 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1246995006150 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995006151 ABC-ATPase subunit interface; other site 1246995006152 putative PBP binding loops; other site 1246995006153 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1246995006154 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995006155 dimer interface [polypeptide binding]; other site 1246995006156 conserved gate region; other site 1246995006157 putative PBP binding loops; other site 1246995006158 ABC-ATPase subunit interface; other site 1246995006159 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1246995006160 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1246995006161 Walker A/P-loop; other site 1246995006162 ATP binding site [chemical binding]; other site 1246995006163 Q-loop/lid; other site 1246995006164 ABC transporter signature motif; other site 1246995006165 Walker B; other site 1246995006166 D-loop; other site 1246995006167 H-loop/switch region; other site 1246995006168 SnoaL-like domain; Region: SnoaL_2; pfam12680 1246995006169 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1246995006170 Domain of unknown function (DUF3472); Region: DUF3472; pfam11958 1246995006171 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1246995006172 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1246995006173 active site 1246995006174 catalytic tetrad [active] 1246995006175 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1246995006176 dimerization interface [polypeptide binding]; other site 1246995006177 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1246995006178 dimer interface [polypeptide binding]; other site 1246995006179 phosphorylation site [posttranslational modification] 1246995006180 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995006181 ATP binding site [chemical binding]; other site 1246995006182 Mg2+ binding site [ion binding]; other site 1246995006183 G-X-G motif; other site 1246995006184 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1246995006185 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995006186 active site 1246995006187 phosphorylation site [posttranslational modification] 1246995006188 intermolecular recognition site; other site 1246995006189 dimerization interface [polypeptide binding]; other site 1246995006190 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1246995006191 DNA binding site [nucleotide binding] 1246995006192 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1246995006193 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1246995006194 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1246995006195 glutamine binding [chemical binding]; other site 1246995006196 catalytic triad [active] 1246995006197 Response regulator receiver domain; Region: Response_reg; pfam00072 1246995006198 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995006199 active site 1246995006200 phosphorylation site [posttranslational modification] 1246995006201 intermolecular recognition site; other site 1246995006202 dimerization interface [polypeptide binding]; other site 1246995006203 CHASE3 domain; Region: CHASE3; cl05000 1246995006204 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1246995006205 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1246995006206 dimer interface [polypeptide binding]; other site 1246995006207 phosphorylation site [posttranslational modification] 1246995006208 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995006209 ATP binding site [chemical binding]; other site 1246995006210 Mg2+ binding site [ion binding]; other site 1246995006211 G-X-G motif; other site 1246995006212 Beta-lactamase; Region: Beta-lactamase; pfam00144 1246995006213 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1246995006214 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1246995006215 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1246995006216 DNA binding site [nucleotide binding] 1246995006217 domain linker motif; other site 1246995006218 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 1246995006219 putative dimerization interface [polypeptide binding]; other site 1246995006220 putative ligand binding site [chemical binding]; other site 1246995006221 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 1246995006222 active site 1246995006223 catalytic site [active] 1246995006224 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1246995006225 Predicted nucleotide kinase (related to CMP and AMP kinases) [Nucleotide transport and metabolism]; Region: COG1936 1246995006226 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1246995006227 S-adenosylmethionine binding site [chemical binding]; other site 1246995006228 Predicted transcriptional regulators [Transcription]; Region: COG1733 1246995006229 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1246995006230 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1246995006231 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1246995006232 active site 1246995006233 catalytic tetrad [active] 1246995006234 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 1246995006235 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1246995006236 YceI-like domain; Region: YceI; smart00867 1246995006237 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1246995006238 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1246995006239 Walker A/P-loop; other site 1246995006240 ATP binding site [chemical binding]; other site 1246995006241 Q-loop/lid; other site 1246995006242 ABC transporter signature motif; other site 1246995006243 Walker B; other site 1246995006244 D-loop; other site 1246995006245 H-loop/switch region; other site 1246995006246 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 1246995006247 aminotransferase AlaT; Validated; Region: PRK09265 1246995006248 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1246995006249 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1246995006250 homodimer interface [polypeptide binding]; other site 1246995006251 catalytic residue [active] 1246995006252 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1246995006253 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1246995006254 putative sugar binding sites [chemical binding]; other site 1246995006255 Q-X-W motif; other site 1246995006256 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1246995006257 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 1246995006258 dimer interface [polypeptide binding]; other site 1246995006259 phosphorylation site [posttranslational modification] 1246995006260 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995006261 ATP binding site [chemical binding]; other site 1246995006262 Mg2+ binding site [ion binding]; other site 1246995006263 G-X-G motif; other site 1246995006264 Response regulator receiver domain; Region: Response_reg; pfam00072 1246995006265 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995006266 active site 1246995006267 phosphorylation site [posttranslational modification] 1246995006268 intermolecular recognition site; other site 1246995006269 dimerization interface [polypeptide binding]; other site 1246995006270 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 1246995006271 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 1246995006272 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1246995006273 DXD motif; other site 1246995006274 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 1246995006275 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1246995006276 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1246995006277 non-specific DNA binding site [nucleotide binding]; other site 1246995006278 salt bridge; other site 1246995006279 sequence-specific DNA binding site [nucleotide binding]; other site 1246995006280 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1246995006281 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1246995006282 binding surface 1246995006283 TPR motif; other site 1246995006284 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1246995006285 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1246995006286 binding surface 1246995006287 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1246995006288 TPR motif; other site 1246995006289 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1246995006290 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1246995006291 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1246995006292 active site 1246995006293 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995006294 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 1246995006295 DNA binding residues [nucleotide binding] 1246995006296 dimerization interface [polypeptide binding]; other site 1246995006297 VanZ like family; Region: VanZ; pfam04892 1246995006298 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1246995006299 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1246995006300 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 1246995006301 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1246995006302 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1246995006303 NAD(P) binding site [chemical binding]; other site 1246995006304 homodimer interface [polypeptide binding]; other site 1246995006305 substrate binding site [chemical binding]; other site 1246995006306 active site 1246995006307 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 1246995006308 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995006309 NAD(P) binding site [chemical binding]; other site 1246995006310 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1246995006311 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1246995006312 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1246995006313 YCII-related domain; Region: YCII; cl00999 1246995006314 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 1246995006315 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1246995006316 putative NAD(P) binding site [chemical binding]; other site 1246995006317 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 1246995006318 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1246995006319 short chain dehydrogenase; Provisional; Region: PRK06500 1246995006320 classical (c) SDRs; Region: SDR_c; cd05233 1246995006321 NAD(P) binding site [chemical binding]; other site 1246995006322 active site 1246995006323 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1246995006324 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1246995006325 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1246995006326 dimerization interface [polypeptide binding]; other site 1246995006327 substrate binding pocket [chemical binding]; other site 1246995006328 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1246995006329 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1246995006330 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1246995006331 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1246995006332 Coenzyme A binding pocket [chemical binding]; other site 1246995006333 salicylyl-CoA 5-hydroxylase; Reviewed; Region: PRK08255 1246995006334 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1246995006335 O-Antigen ligase; Region: Wzy_C; pfam04932 1246995006336 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1246995006337 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1246995006338 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1246995006339 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1246995006340 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 1246995006341 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 1246995006342 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1246995006343 inhibitor-cofactor binding pocket; inhibition site 1246995006344 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1246995006345 catalytic residue [active] 1246995006346 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1246995006347 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1246995006348 putative active site [active] 1246995006349 putative metal binding site [ion binding]; other site 1246995006350 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1246995006351 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 1246995006352 Protein of unknown function (DUF3253); Region: DUF3253; pfam11625 1246995006353 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 1246995006354 dimer interface [polypeptide binding]; other site 1246995006355 ligand binding site [chemical binding]; other site 1246995006356 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 1246995006357 active site 1246995006358 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1246995006359 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1246995006360 Coenzyme A binding pocket [chemical binding]; other site 1246995006361 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1246995006362 RibD C-terminal domain; Region: RibD_C; cl17279 1246995006363 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1246995006364 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1246995006365 active site 1246995006366 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 1246995006367 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 1246995006368 BNR repeat-like domain; Region: BNR_2; pfam13088 1246995006369 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1246995006370 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 1246995006371 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1246995006372 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1246995006373 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1246995006374 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1246995006375 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1246995006376 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1246995006377 putative Zn2+ binding site [ion binding]; other site 1246995006378 putative DNA binding site [nucleotide binding]; other site 1246995006379 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1246995006380 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 1246995006381 NAD(P) binding site [chemical binding]; other site 1246995006382 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1246995006383 putative hydrophobic ligand binding site [chemical binding]; other site 1246995006384 protein interface [polypeptide binding]; other site 1246995006385 gate; other site 1246995006386 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1246995006387 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1246995006388 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 1246995006389 H+ Antiporter protein; Region: 2A0121; TIGR00900 1246995006390 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1246995006391 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1246995006392 ATP binding site [chemical binding]; other site 1246995006393 putative Mg++ binding site [ion binding]; other site 1246995006394 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1246995006395 nucleotide binding region [chemical binding]; other site 1246995006396 ATP-binding site [chemical binding]; other site 1246995006397 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1246995006398 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1246995006399 AAA ATPase domain; Region: AAA_16; pfam13191 1246995006400 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995006401 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995006402 DNA binding residues [nucleotide binding] 1246995006403 dimerization interface [polypeptide binding]; other site 1246995006404 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1246995006405 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1246995006406 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1246995006407 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1246995006408 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1246995006409 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1246995006410 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1246995006411 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1246995006412 active site 1246995006413 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 1246995006414 active site 1246995006415 Epoxide hydrolase N terminus; Region: EHN; pfam06441 1246995006416 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1246995006417 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1246995006418 anti sigma factor interaction site; other site 1246995006419 regulatory phosphorylation site [posttranslational modification]; other site 1246995006420 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1246995006421 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1246995006422 ATP binding site [chemical binding]; other site 1246995006423 Mg2+ binding site [ion binding]; other site 1246995006424 G-X-G motif; other site 1246995006425 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1246995006426 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1246995006427 metal binding site [ion binding]; metal-binding site 1246995006428 active site 1246995006429 I-site; other site 1246995006430 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1246995006431 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1246995006432 classical (c) SDRs; Region: SDR_c; cd05233 1246995006433 NAD(P) binding site [chemical binding]; other site 1246995006434 active site 1246995006435 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1246995006436 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1246995006437 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1246995006438 dimerization interface [polypeptide binding]; other site 1246995006439 substrate binding pocket [chemical binding]; other site 1246995006440 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1246995006441 MarR family; Region: MarR_2; pfam12802 1246995006442 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 1246995006443 AAA ATPase domain; Region: AAA_16; pfam13191 1246995006444 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995006445 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995006446 DNA binding residues [nucleotide binding] 1246995006447 dimerization interface [polypeptide binding]; other site 1246995006448 short chain dehydrogenase; Provisional; Region: PRK06523 1246995006449 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995006450 NAD(P) binding site [chemical binding]; other site 1246995006451 active site 1246995006452 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1246995006453 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1246995006454 Lipase (class 2); Region: Lipase_2; pfam01674 1246995006455 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1246995006456 DNA binding site [nucleotide binding] 1246995006457 Bacterial transcriptional activator domain; Region: BTAD; smart01043 1246995006458 short chain dehydrogenase; Provisional; Region: PRK06523 1246995006459 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995006460 NAD(P) binding site [chemical binding]; other site 1246995006461 active site 1246995006462 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995006463 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995006464 potential frameshift: common BLAST hit: gi|145593547|ref|YP_001157844.1| type 11 methyltransferase 1246995006465 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1246995006466 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1246995006467 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995006468 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995006469 WHG domain; Region: WHG; pfam13305 1246995006470 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 1246995006471 Protein of unknown function (DUF998); Region: DUF998; pfam06197 1246995006472 Predicted membrane protein [Function unknown]; Region: COG3371 1246995006473 Epoxide hydrolase N terminus; Region: EHN; pfam06441 1246995006474 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1246995006475 YCII-related domain; Region: YCII; cl00999 1246995006476 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1246995006477 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1246995006478 dimer interface [polypeptide binding]; other site 1246995006479 putative CheW interface [polypeptide binding]; other site 1246995006480 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1246995006481 PAS fold; Region: PAS_3; pfam08447 1246995006482 putative active site [active] 1246995006483 heme pocket [chemical binding]; other site 1246995006484 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1246995006485 dimerization interface [polypeptide binding]; other site 1246995006486 putative DNA binding site [nucleotide binding]; other site 1246995006487 putative Zn2+ binding site [ion binding]; other site 1246995006488 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1246995006489 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1246995006490 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1246995006491 Protein of unknown function DUF58; Region: DUF58; pfam01882 1246995006492 MoxR-like ATPases [General function prediction only]; Region: COG0714 1246995006493 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1246995006494 Walker A motif; other site 1246995006495 ATP binding site [chemical binding]; other site 1246995006496 Walker B motif; other site 1246995006497 arginine finger; other site 1246995006498 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1246995006499 Interdomain contacts; other site 1246995006500 Cytokine receptor motif; other site 1246995006501 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1246995006502 Interdomain contacts; other site 1246995006503 Cytokine receptor motif; other site 1246995006504 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1246995006505 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1246995006506 Cytokine receptor motif; other site 1246995006507 potential protein location (hypothetical protein AFR_12065 [Actinoplanes friuliensis DSM 7358]) that overlaps RNA (tRNA-L) 1246995006508 TIR domain; Region: TIR_2; pfam13676 1246995006509 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1246995006510 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1246995006511 Walker A motif; other site 1246995006512 ATP binding site [chemical binding]; other site 1246995006513 Walker B motif; other site 1246995006514 arginine finger; other site 1246995006515 Lecithin:cholesterol acyltransferase; Region: LACT; pfam02450 1246995006516 TIR domain; Region: TIR_2; pfam13676 1246995006517 HEAT repeats; Region: HEAT_2; pfam13646 1246995006518 HEAT repeats; Region: HEAT_2; pfam13646 1246995006519 Domain of unknown function (DUF4062); Region: DUF4062; pfam13271 1246995006520 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1246995006521 DNA-binding site [nucleotide binding]; DNA binding site 1246995006522 RNA-binding motif; other site 1246995006523 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1246995006524 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1246995006525 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1246995006526 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1246995006527 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1246995006528 Cupin; Region: Cupin_6; pfam12852 1246995006529 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1246995006530 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1246995006531 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1246995006532 Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324 1246995006533 NADP binding site [chemical binding]; other site 1246995006534 substrate binding site [chemical binding]; other site 1246995006535 active site 1246995006536 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1246995006537 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1246995006538 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1246995006539 conserved cys residue [active] 1246995006540 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 1246995006541 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995006542 active site 1246995006543 Helix-turn-helix domain; Region: HTH_31; pfam13560 1246995006544 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 1246995006545 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1246995006546 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1246995006547 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1246995006548 active site 1246995006549 catalytic tetrad [active] 1246995006550 Protein of unknown function (DUF1271); Region: DUF1271; pfam06902 1246995006551 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; cl02748 1246995006552 Predicted acetyltransferase [General function prediction only]; Region: COG2388 1246995006553 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 1246995006554 TAP-like protein; Region: Abhydrolase_4; pfam08386 1246995006555 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1246995006556 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1246995006557 DNA binding residues [nucleotide binding] 1246995006558 AAA ATPase domain; Region: AAA_16; pfam13191 1246995006559 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995006560 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995006561 DNA binding residues [nucleotide binding] 1246995006562 dimerization interface [polypeptide binding]; other site 1246995006563 Histidine kinase; Region: HisKA_3; pfam07730 1246995006564 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1246995006565 ATP binding site [chemical binding]; other site 1246995006566 Mg2+ binding site [ion binding]; other site 1246995006567 G-X-G motif; other site 1246995006568 Cupin domain; Region: Cupin_2; pfam07883 1246995006569 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1246995006570 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 1246995006571 CAAX protease self-immunity; Region: Abi; pfam02517 1246995006572 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1246995006573 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1246995006574 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995006575 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995006576 DNA binding residues [nucleotide binding] 1246995006577 dimerization interface [polypeptide binding]; other site 1246995006578 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 1246995006579 SnoaL-like domain; Region: SnoaL_2; pfam12680 1246995006580 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1246995006581 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1246995006582 DNA binding residues [nucleotide binding] 1246995006583 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1246995006584 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1246995006585 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1246995006586 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1246995006587 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1246995006588 Epoxide hydrolase N terminus; Region: EHN; pfam06441 1246995006589 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1246995006590 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995006591 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995006592 active site 1246995006593 phosphorylation site [posttranslational modification] 1246995006594 intermolecular recognition site; other site 1246995006595 dimerization interface [polypeptide binding]; other site 1246995006596 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995006597 DNA binding residues [nucleotide binding] 1246995006598 dimerization interface [polypeptide binding]; other site 1246995006599 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1246995006600 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1246995006601 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1246995006602 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 1246995006603 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 1246995006604 dimer interface [polypeptide binding]; other site 1246995006605 active site 1246995006606 heme binding site [chemical binding]; other site 1246995006607 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 1246995006608 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 1246995006609 Asn-Pro-Ala signature motifs; other site 1246995006610 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 1246995006611 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 1246995006612 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 1246995006613 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1246995006614 DNA binding residues [nucleotide binding] 1246995006615 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 1246995006616 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1246995006617 Cellulose binding domain; Region: CBM_2; pfam00553 1246995006618 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1246995006619 Beta-lactamase; Region: Beta-lactamase; pfam00144 1246995006620 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1246995006621 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1246995006622 acyl-activating enzyme (AAE) consensus motif; other site 1246995006623 AMP binding site [chemical binding]; other site 1246995006624 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1246995006625 Condensation domain; Region: Condensation; pfam00668 1246995006626 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1246995006627 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1246995006628 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1246995006629 acyl-activating enzyme (AAE) consensus motif; other site 1246995006630 AMP binding site [chemical binding]; other site 1246995006631 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1246995006632 Condensation domain; Region: Condensation; pfam00668 1246995006633 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1246995006634 Condensation domain; Region: Condensation; pfam00668 1246995006635 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1246995006636 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1246995006637 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1246995006638 acyl-activating enzyme (AAE) consensus motif; other site 1246995006639 AMP binding site [chemical binding]; other site 1246995006640 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1246995006641 peptide synthase; Provisional; Region: PRK12316 1246995006642 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1246995006643 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1246995006644 acyl-activating enzyme (AAE) consensus motif; other site 1246995006645 AMP binding site [chemical binding]; other site 1246995006646 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1246995006647 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1246995006648 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1246995006649 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1246995006650 acyl-activating enzyme (AAE) consensus motif; other site 1246995006651 AMP binding site [chemical binding]; other site 1246995006652 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1246995006653 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1246995006654 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1246995006655 acyl-activating enzyme (AAE) consensus motif; other site 1246995006656 AMP binding site [chemical binding]; other site 1246995006657 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1246995006658 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1246995006659 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1246995006660 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1246995006661 acyl-activating enzyme (AAE) consensus motif; other site 1246995006662 AMP binding site [chemical binding]; other site 1246995006663 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1246995006664 Condensation domain; Region: Condensation; pfam00668 1246995006665 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1246995006666 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1246995006667 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1246995006668 acyl-activating enzyme (AAE) consensus motif; other site 1246995006669 AMP binding site [chemical binding]; other site 1246995006670 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1246995006671 Condensation domain; Region: Condensation; pfam00668 1246995006672 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1246995006673 H+ Antiporter protein; Region: 2A0121; TIGR00900 1246995006674 MbtH-like protein; Region: MbtH; cl01279 1246995006675 Histidine kinase; Region: HisKA_3; pfam07730 1246995006676 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1246995006677 Mg2+ binding site [ion binding]; other site 1246995006678 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995006679 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995006680 active site 1246995006681 phosphorylation site [posttranslational modification] 1246995006682 intermolecular recognition site; other site 1246995006683 dimerization interface [polypeptide binding]; other site 1246995006684 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995006685 DNA binding residues [nucleotide binding] 1246995006686 dimerization interface [polypeptide binding]; other site 1246995006687 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1246995006688 Domain of unknown function DUF11; Region: DUF11; cl17728 1246995006689 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1246995006690 G1 box; other site 1246995006691 G1 box; other site 1246995006692 GTP/Mg2+ binding site [chemical binding]; other site 1246995006693 GTP/Mg2+ binding site [chemical binding]; other site 1246995006694 G2 box; other site 1246995006695 Switch I region; other site 1246995006696 G3 box; other site 1246995006697 Switch II region; other site 1246995006698 G4 box; other site 1246995006699 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1246995006700 G1 box; other site 1246995006701 GTP/Mg2+ binding site [chemical binding]; other site 1246995006702 G2 box; other site 1246995006703 Switch I region; other site 1246995006704 G3 box; other site 1246995006705 Switch II region; other site 1246995006706 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1246995006707 G3 box; other site 1246995006708 Switch II region; other site 1246995006709 GTP/Mg2+ binding site [chemical binding]; other site 1246995006710 G4 box; other site 1246995006711 G5 box; other site 1246995006712 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1246995006713 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995006714 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995006715 DNA binding residues [nucleotide binding] 1246995006716 dimerization interface [polypeptide binding]; other site 1246995006717 Nitrate and nitrite sensing; Region: NIT; pfam08376 1246995006718 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995006719 ATP binding site [chemical binding]; other site 1246995006720 Mg2+ binding site [ion binding]; other site 1246995006721 G-X-G motif; other site 1246995006722 Protein of unknown function (DUF742); Region: DUF742; pfam05331 1246995006723 CBD_II domain; Region: CBD_II; smart00637 1246995006724 Fic family protein [Function unknown]; Region: COG3177 1246995006725 Fic/DOC family; Region: Fic; pfam02661 1246995006726 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1246995006727 GAF domain; Region: GAF; pfam01590 1246995006728 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1246995006729 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1246995006730 putative active site [active] 1246995006731 heme pocket [chemical binding]; other site 1246995006732 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1246995006733 dimer interface [polypeptide binding]; other site 1246995006734 phosphorylation site [posttranslational modification] 1246995006735 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995006736 ATP binding site [chemical binding]; other site 1246995006737 Mg2+ binding site [ion binding]; other site 1246995006738 G-X-G motif; other site 1246995006739 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1246995006740 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1246995006741 Helix-turn-helix domain; Region: HTH_38; pfam13936 1246995006742 MarR family; Region: MarR_2; pfam12802 1246995006743 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995006744 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995006745 active site 1246995006746 phosphorylation site [posttranslational modification] 1246995006747 intermolecular recognition site; other site 1246995006748 dimerization interface [polypeptide binding]; other site 1246995006749 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995006750 DNA binding residues [nucleotide binding] 1246995006751 dimerization interface [polypeptide binding]; other site 1246995006752 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1246995006753 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995006754 ATP binding site [chemical binding]; other site 1246995006755 Mg2+ binding site [ion binding]; other site 1246995006756 G-X-G motif; other site 1246995006757 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1246995006758 Alpha-lytic protease prodomain; Region: Pro_Al_protease; pfam02983 1246995006759 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1246995006760 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1246995006761 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1246995006762 putative sugar binding sites [chemical binding]; other site 1246995006763 Q-X-W motif; other site 1246995006764 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1246995006765 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1246995006766 Walker A/P-loop; other site 1246995006767 ATP binding site [chemical binding]; other site 1246995006768 Q-loop/lid; other site 1246995006769 ABC transporter signature motif; other site 1246995006770 Walker B; other site 1246995006771 D-loop; other site 1246995006772 H-loop/switch region; other site 1246995006773 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995006774 light-dependent protochlorophyllide reductase; Region: LPOR; TIGR01289 1246995006775 NAD(P) binding site [chemical binding]; other site 1246995006776 active site 1246995006777 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1246995006778 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1246995006779 NAD(P) binding site [chemical binding]; other site 1246995006780 catalytic residues [active] 1246995006781 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1246995006782 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1246995006783 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1246995006784 Bacterial transcriptional regulator; Region: IclR; pfam01614 1246995006785 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1246995006786 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1246995006787 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995006788 putative PBP binding loops; other site 1246995006789 dimer interface [polypeptide binding]; other site 1246995006790 ABC-ATPase subunit interface; other site 1246995006791 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1246995006792 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995006793 dimer interface [polypeptide binding]; other site 1246995006794 conserved gate region; other site 1246995006795 putative PBP binding loops; other site 1246995006796 ABC-ATPase subunit interface; other site 1246995006797 hydrophobic ligand binding site; other site 1246995006798 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 1246995006799 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1246995006800 salt bridge; other site 1246995006801 non-specific DNA binding site [nucleotide binding]; other site 1246995006802 sequence-specific DNA binding site [nucleotide binding]; other site 1246995006803 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1246995006804 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1246995006805 putative NAD(P) binding site [chemical binding]; other site 1246995006806 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 1246995006807 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1246995006808 putative NAD(P) binding site [chemical binding]; other site 1246995006809 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1246995006810 MarR family; Region: MarR_2; pfam12802 1246995006811 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1246995006812 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 1246995006813 FAD binding pocket [chemical binding]; other site 1246995006814 FAD binding motif [chemical binding]; other site 1246995006815 phosphate binding motif [ion binding]; other site 1246995006816 beta-alpha-beta structure motif; other site 1246995006817 NAD binding pocket [chemical binding]; other site 1246995006818 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995006819 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995006820 RibD C-terminal domain; Region: RibD_C; cl17279 1246995006821 Predicted transcriptional regulator [Transcription]; Region: COG2378 1246995006822 WYL domain; Region: WYL; pfam13280 1246995006823 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1246995006824 dimer interface [polypeptide binding]; other site 1246995006825 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1246995006826 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1246995006827 PQQ-like domain; Region: PQQ_2; pfam13360 1246995006828 Trp docking motif [polypeptide binding]; other site 1246995006829 active site 1246995006830 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1246995006831 Zn2+ binding site [ion binding]; other site 1246995006832 Mg2+ binding site [ion binding]; other site 1246995006833 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 1246995006834 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1246995006835 Leucine carboxyl methyltransferase; Region: LCM; cl01306 1246995006836 Domain of unknown function (DUF4387); Region: DUF4387; pfam14330 1246995006837 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 1246995006838 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1246995006839 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1246995006840 NAD binding site [chemical binding]; other site 1246995006841 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1246995006842 putative substrate translocation pore; other site 1246995006843 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1246995006844 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1246995006845 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1246995006846 DNA-binding site [nucleotide binding]; DNA binding site 1246995006847 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1246995006848 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 1246995006849 tartrate dehydrogenase; Region: TTC; TIGR02089 1246995006850 Cupin; Region: Cupin_6; pfam12852 1246995006851 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1246995006852 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1246995006853 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1246995006854 putative NAD(P) binding site [chemical binding]; other site 1246995006855 Transposase IS200 like; Region: Y1_Tnp; cl00848 1246995006856 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1246995006857 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1246995006858 Probable transposase; Region: OrfB_IS605; pfam01385 1246995006859 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1246995006860 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1246995006861 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1246995006862 S-adenosylmethionine binding site [chemical binding]; other site 1246995006863 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 1246995006864 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995006865 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995006866 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995006867 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995006868 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1246995006869 Helix-turn-helix domain; Region: HTH_31; pfam13560 1246995006870 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995006871 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1246995006872 NAD(P) binding site [chemical binding]; other site 1246995006873 active site 1246995006874 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1246995006875 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995006876 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1246995006877 DNA binding residues [nucleotide binding] 1246995006878 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995006879 Walker A/P-loop; other site 1246995006880 ATP binding site [chemical binding]; other site 1246995006881 ABC transporter; Region: ABC_tran; pfam00005 1246995006882 Q-loop/lid; other site 1246995006883 ABC transporter signature motif; other site 1246995006884 Walker B; other site 1246995006885 D-loop; other site 1246995006886 H-loop/switch region; other site 1246995006887 short chain dehydrogenase; Validated; Region: PRK08264 1246995006888 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995006889 NAD(P) binding site [chemical binding]; other site 1246995006890 active site 1246995006891 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995006892 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995006893 Predicted integral membrane protein [Function unknown]; Region: COG0392 1246995006894 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1246995006895 hydrophobic ligand binding site; other site 1246995006896 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995006897 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995006898 hypothetical protein; Provisional; Region: PRK06184 1246995006899 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1246995006900 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 1246995006901 active site 1246995006902 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1246995006903 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1246995006904 putative sugar binding sites [chemical binding]; other site 1246995006905 Q-X-W motif; other site 1246995006906 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1246995006907 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1246995006908 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1246995006909 putative sugar binding sites [chemical binding]; other site 1246995006910 Q-X-W motif; other site 1246995006911 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1246995006912 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1246995006913 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1246995006914 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1246995006915 FtsH Extracellular; Region: FtsH_ext; pfam06480 1246995006916 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1246995006917 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1246995006918 Walker A motif; other site 1246995006919 ATP binding site [chemical binding]; other site 1246995006920 Walker B motif; other site 1246995006921 arginine finger; other site 1246995006922 Peptidase family M41; Region: Peptidase_M41; pfam01434 1246995006923 EthD domain; Region: EthD; cl17553 1246995006924 Predicted transcriptional regulators [Transcription]; Region: COG1695 1246995006925 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1246995006926 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1246995006927 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1246995006928 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 1246995006929 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1246995006930 catalytic residues [active] 1246995006931 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1246995006932 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1246995006933 active site 1246995006934 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1246995006935 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995006936 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1246995006937 DNA binding residues [nucleotide binding] 1246995006938 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995006939 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995006940 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1246995006941 FAD binding domain; Region: FAD_binding_4; pfam01565 1246995006942 Berberine and berberine like; Region: BBE; pfam08031 1246995006943 short chain dehydrogenase; Provisional; Region: PRK06180 1246995006944 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995006945 NAD(P) binding site [chemical binding]; other site 1246995006946 active site 1246995006947 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1246995006948 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1246995006949 salt bridge; other site 1246995006950 non-specific DNA binding site [nucleotide binding]; other site 1246995006951 sequence-specific DNA binding site [nucleotide binding]; other site 1246995006952 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 1246995006953 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1246995006954 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1246995006955 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1246995006956 putative substrate translocation pore; other site 1246995006957 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1246995006958 putative Zn2+ binding site [ion binding]; other site 1246995006959 putative DNA binding site [nucleotide binding]; other site 1246995006960 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1246995006961 Chorismate mutase type II; Region: CM_2; cl00693 1246995006962 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 1246995006963 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995006964 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1246995006965 DNA binding residues [nucleotide binding] 1246995006966 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995006967 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995006968 active site 1246995006969 phosphorylation site [posttranslational modification] 1246995006970 intermolecular recognition site; other site 1246995006971 dimerization interface [polypeptide binding]; other site 1246995006972 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995006973 DNA binding residues [nucleotide binding] 1246995006974 dimerization interface [polypeptide binding]; other site 1246995006975 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 1246995006976 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1246995006977 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1246995006978 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1246995006979 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1246995006980 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 1246995006981 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1246995006982 conserved cys residue [active] 1246995006983 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1246995006984 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1246995006985 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1246995006986 salt bridge; other site 1246995006987 non-specific DNA binding site [nucleotide binding]; other site 1246995006988 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1246995006989 sequence-specific DNA binding site [nucleotide binding]; other site 1246995006990 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1246995006991 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1246995006992 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995006993 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995006994 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 1246995006995 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995006996 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995006997 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1246995006998 classical (c) SDRs; Region: SDR_c; cd05233 1246995006999 NAD(P) binding site [chemical binding]; other site 1246995007000 active site 1246995007001 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1246995007002 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1246995007003 active site 1246995007004 catalytic tetrad [active] 1246995007005 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995007006 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995007007 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 1246995007008 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1246995007009 putative substrate translocation pore; other site 1246995007010 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1246995007011 Beta-lactamase; Region: Beta-lactamase; pfam00144 1246995007012 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995007013 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995007014 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1246995007015 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1246995007016 putative NAD(P) binding site [chemical binding]; other site 1246995007017 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1246995007018 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995007019 NAD(P) binding site [chemical binding]; other site 1246995007020 active site 1246995007021 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1246995007022 MarR family; Region: MarR; pfam01047 1246995007023 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1246995007024 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995007025 NAD(P) binding site [chemical binding]; other site 1246995007026 active site 1246995007027 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995007028 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995007029 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 1246995007030 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1246995007031 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1246995007032 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 1246995007033 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 1246995007034 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1246995007035 active site 1246995007036 metal binding site [ion binding]; metal-binding site 1246995007037 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995007038 NAD(P) binding site [chemical binding]; other site 1246995007039 active site 1246995007040 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995007041 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995007042 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 1246995007043 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1246995007044 ligand binding site [chemical binding]; other site 1246995007045 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1246995007046 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1246995007047 TM-ABC transporter signature motif; other site 1246995007048 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1246995007049 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1246995007050 Walker A/P-loop; other site 1246995007051 ATP binding site [chemical binding]; other site 1246995007052 Q-loop/lid; other site 1246995007053 ABC transporter signature motif; other site 1246995007054 Walker B; other site 1246995007055 D-loop; other site 1246995007056 H-loop/switch region; other site 1246995007057 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1246995007058 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 1246995007059 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 1246995007060 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 1246995007061 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 1246995007062 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 1246995007063 hypothetical protein; Provisional; Region: PRK06126 1246995007064 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1246995007065 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1246995007066 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1246995007067 TAP-like protein; Region: Abhydrolase_4; pfam08386 1246995007068 choline dehydrogenase; Validated; Region: PRK02106 1246995007069 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1246995007070 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1246995007071 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1246995007072 putative substrate translocation pore; other site 1246995007073 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995007074 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 1246995007075 active site 1246995007076 catalytic site [active] 1246995007077 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; pfam09261 1246995007078 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 1246995007079 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1246995007080 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 1246995007081 conserved cys residue [active] 1246995007082 enoyl-CoA hydratase; Provisional; Region: PRK06494 1246995007083 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1246995007084 substrate binding site [chemical binding]; other site 1246995007085 oxyanion hole (OAH) forming residues; other site 1246995007086 trimer interface [polypeptide binding]; other site 1246995007087 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1246995007088 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1246995007089 DNA binding residues [nucleotide binding] 1246995007090 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 1246995007091 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1246995007092 conserved cys residue [active] 1246995007093 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1246995007094 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1246995007095 Isochorismatase family; Region: Isochorismatase; pfam00857 1246995007096 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1246995007097 catalytic triad [active] 1246995007098 conserved cis-peptide bond; other site 1246995007099 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1246995007100 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995007101 active site 1246995007102 phosphorylation site [posttranslational modification] 1246995007103 intermolecular recognition site; other site 1246995007104 dimerization interface [polypeptide binding]; other site 1246995007105 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1246995007106 DNA binding site [nucleotide binding] 1246995007107 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1246995007108 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1246995007109 dimerization interface [polypeptide binding]; other site 1246995007110 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1246995007111 dimer interface [polypeptide binding]; other site 1246995007112 phosphorylation site [posttranslational modification] 1246995007113 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995007114 Mg2+ binding site [ion binding]; other site 1246995007115 G-X-G motif; other site 1246995007116 Predicted membrane protein [Function unknown]; Region: COG3463 1246995007117 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 1246995007118 classical (c) SDR, subgroup 2; Region: SDR_c2; cd05370 1246995007119 putative NAD(P) binding site [chemical binding]; other site 1246995007120 active site 1246995007121 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1246995007122 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1246995007123 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1246995007124 DNA binding site [nucleotide binding] 1246995007125 domain linker motif; other site 1246995007126 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1246995007127 ligand binding site [chemical binding]; other site 1246995007128 dimerization interface [polypeptide binding]; other site 1246995007129 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1246995007130 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1246995007131 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1246995007132 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1246995007133 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995007134 dimer interface [polypeptide binding]; other site 1246995007135 conserved gate region; other site 1246995007136 putative PBP binding loops; other site 1246995007137 ABC-ATPase subunit interface; other site 1246995007138 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1246995007139 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995007140 dimer interface [polypeptide binding]; other site 1246995007141 conserved gate region; other site 1246995007142 putative PBP binding loops; other site 1246995007143 ABC-ATPase subunit interface; other site 1246995007144 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1246995007145 active site 1246995007146 catalytic triad [active] 1246995007147 oxyanion hole [active] 1246995007148 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1246995007149 MarR family; Region: MarR_2; cl17246 1246995007150 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1246995007151 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1246995007152 putative NAD(P) binding site [chemical binding]; other site 1246995007153 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995007154 WHG domain; Region: WHG; pfam13305 1246995007155 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995007156 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995007157 hypothetical protein; Provisional; Region: PRK07588 1246995007158 hypothetical protein; Provisional; Region: PRK07236 1246995007159 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1246995007160 HAMP domain; Region: HAMP; pfam00672 1246995007161 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1246995007162 dimer interface [polypeptide binding]; other site 1246995007163 putative CheW interface [polypeptide binding]; other site 1246995007164 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1246995007165 RHS Repeat; Region: RHS_repeat; pfam05593 1246995007166 RHS Repeat; Region: RHS_repeat; pfam05593 1246995007167 RHS Repeat; Region: RHS_repeat; cl11982 1246995007168 RHS Repeat; Region: RHS_repeat; pfam05593 1246995007169 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1246995007170 Uncharacterized glycoside hydrolase family 99-like domain; Region: GH99_GH71_like_2; cd11576 1246995007171 putative ligand binding site [chemical binding]; other site 1246995007172 putative catalytic site [active] 1246995007173 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1246995007174 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995007175 short chain dehydrogenase; Provisional; Region: PRK06172 1246995007176 NAD(P) binding site [chemical binding]; other site 1246995007177 active site 1246995007178 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995007179 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995007180 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1246995007181 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1246995007182 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995007183 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 1246995007184 cleavage site 1246995007185 active site 1246995007186 substrate binding sites [chemical binding]; other site 1246995007187 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1246995007188 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1246995007189 active site 1246995007190 catalytic tetrad [active] 1246995007191 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995007192 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995007193 Domain of unknown function (DUF4173); Region: DUF4173; pfam13777 1246995007194 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1246995007195 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1246995007196 TM2 domain; Region: TM2; pfam05154 1246995007197 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1246995007198 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995007199 active site 1246995007200 phosphorylation site [posttranslational modification] 1246995007201 intermolecular recognition site; other site 1246995007202 dimerization interface [polypeptide binding]; other site 1246995007203 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1246995007204 DNA binding site [nucleotide binding] 1246995007205 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1246995007206 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1246995007207 dimerization interface [polypeptide binding]; other site 1246995007208 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1246995007209 dimer interface [polypeptide binding]; other site 1246995007210 phosphorylation site [posttranslational modification] 1246995007211 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995007212 ATP binding site [chemical binding]; other site 1246995007213 Mg2+ binding site [ion binding]; other site 1246995007214 G-X-G motif; other site 1246995007215 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1246995007216 FtsX-like permease family; Region: FtsX; pfam02687 1246995007217 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 1246995007218 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995007219 NAD(P) binding site [chemical binding]; other site 1246995007220 active site 1246995007221 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1246995007222 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1246995007223 salt bridge; other site 1246995007224 non-specific DNA binding site [nucleotide binding]; other site 1246995007225 sequence-specific DNA binding site [nucleotide binding]; other site 1246995007226 trehalose synthase; Region: treS_nterm; TIGR02456 1246995007227 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 1246995007228 active site 1246995007229 catalytic site [active] 1246995007230 short chain dehydrogenase; Provisional; Region: PRK06482 1246995007231 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1246995007232 NADP binding site [chemical binding]; other site 1246995007233 active site 1246995007234 steroid binding site; other site 1246995007235 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1246995007236 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1246995007237 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 1246995007238 putative dimerization interface [polypeptide binding]; other site 1246995007239 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995007240 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995007241 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1246995007242 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1246995007243 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1246995007244 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1246995007245 putative substrate translocation pore; other site 1246995007246 Predicted transcriptional regulators [Transcription]; Region: COG1725 1246995007247 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1246995007248 DNA-binding site [nucleotide binding]; DNA binding site 1246995007249 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995007250 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1246995007251 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1246995007252 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1246995007253 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1246995007254 active site 1246995007255 GAF domain; Region: GAF; pfam01590 1246995007256 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1246995007257 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1246995007258 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 1246995007259 G2 box; other site 1246995007260 Switch I region; other site 1246995007261 G3 box; other site 1246995007262 Switch II region; other site 1246995007263 GTP/Mg2+ binding site [chemical binding]; other site 1246995007264 G4 box; other site 1246995007265 G5 box; other site 1246995007266 Protein of unknown function (DUF742); Region: DUF742; pfam05331 1246995007267 Roadblock/LC7 domain; Region: Robl_LC7; pfam03259 1246995007268 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1246995007269 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995007270 ATP binding site [chemical binding]; other site 1246995007271 Mg2+ binding site [ion binding]; other site 1246995007272 G-X-G motif; other site 1246995007273 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1246995007274 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1246995007275 DNA-binding site [nucleotide binding]; DNA binding site 1246995007276 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1246995007277 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 1246995007278 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 1246995007279 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1246995007280 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1246995007281 Walker A motif; other site 1246995007282 ATP binding site [chemical binding]; other site 1246995007283 Walker B motif; other site 1246995007284 arginine finger; other site 1246995007285 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1246995007286 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 1246995007287 catalytic tetrad [active] 1246995007288 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 1246995007289 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1246995007290 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995007291 NAD(P) binding site [chemical binding]; other site 1246995007292 active site 1246995007293 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995007294 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995007295 WHG domain; Region: WHG; pfam13305 1246995007296 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1246995007297 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1246995007298 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1246995007299 dimerization interface [polypeptide binding]; other site 1246995007300 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995007301 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1246995007302 NAD(P) binding site [chemical binding]; other site 1246995007303 active site 1246995007304 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1246995007305 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1246995007306 putative substrate translocation pore; other site 1246995007307 Domain of unknown function (DUF427); Region: DUF427; pfam04248 1246995007308 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1246995007309 classical (c) SDRs; Region: SDR_c; cd05233 1246995007310 NAD(P) binding site [chemical binding]; other site 1246995007311 active site 1246995007312 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1246995007313 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1246995007314 salt bridge; other site 1246995007315 non-specific DNA binding site [nucleotide binding]; other site 1246995007316 sequence-specific DNA binding site [nucleotide binding]; other site 1246995007317 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1246995007318 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995007319 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1246995007320 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1246995007321 salt bridge; other site 1246995007322 non-specific DNA binding site [nucleotide binding]; other site 1246995007323 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1246995007324 sequence-specific DNA binding site [nucleotide binding]; other site 1246995007325 short chain dehydrogenase; Provisional; Region: PRK08219 1246995007326 classical (c) SDRs; Region: SDR_c; cd05233 1246995007327 NAD(P) binding site [chemical binding]; other site 1246995007328 active site 1246995007329 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1246995007330 FOG: CBS domain [General function prediction only]; Region: COG0517 1246995007331 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1246995007332 BON domain; Region: BON; pfam04972 1246995007333 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 1246995007334 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1246995007335 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 1246995007336 FOG: CBS domain [General function prediction only]; Region: COG0517 1246995007337 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1246995007338 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1246995007339 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1246995007340 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995007341 Uncharacterized conserved protein [Function unknown]; Region: COG3268 1246995007342 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922 1246995007343 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995007344 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995007345 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1246995007346 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1246995007347 NAD binding site [chemical binding]; other site 1246995007348 substrate binding site [chemical binding]; other site 1246995007349 putative active site [active] 1246995007350 short chain dehydrogenase; Provisional; Region: PRK06197 1246995007351 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995007352 NAD(P) binding site [chemical binding]; other site 1246995007353 active site 1246995007354 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1246995007355 Uncharacterized protein conserved in bacteria (DUF2255); Region: DUF2255; cl01788 1246995007356 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1246995007357 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1246995007358 salt bridge; other site 1246995007359 non-specific DNA binding site [nucleotide binding]; other site 1246995007360 sequence-specific DNA binding site [nucleotide binding]; other site 1246995007361 short chain dehydrogenase; Provisional; Region: PRK06940 1246995007362 classical (c) SDRs; Region: SDR_c; cd05233 1246995007363 NAD(P) binding site [chemical binding]; other site 1246995007364 active site 1246995007365 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1246995007366 salt bridge; other site 1246995007367 non-specific DNA binding site [nucleotide binding]; other site 1246995007368 sequence-specific DNA binding site [nucleotide binding]; other site 1246995007369 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 1246995007370 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 1246995007371 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1246995007372 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1246995007373 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1246995007374 Domain of unknown function (DUF4260); Region: DUF4260; pfam14079 1246995007375 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995007376 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995007377 Predicted membrane protein [Function unknown]; Region: COG4129 1246995007378 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1246995007379 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 1246995007380 putative hydrophobic ligand binding site [chemical binding]; other site 1246995007381 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1246995007382 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1246995007383 NAD binding site [chemical binding]; other site 1246995007384 catalytic Zn binding site [ion binding]; other site 1246995007385 structural Zn binding site [ion binding]; other site 1246995007386 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1246995007387 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1246995007388 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1246995007389 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1246995007390 anti sigma factor interaction site; other site 1246995007391 regulatory phosphorylation site [posttranslational modification]; other site 1246995007392 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1246995007393 active site 1246995007394 substrate binding site [chemical binding]; other site 1246995007395 ATP binding site [chemical binding]; other site 1246995007396 Phosphotransferase enzyme family; Region: APH; pfam01636 1246995007397 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 1246995007398 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1246995007399 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995007400 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995007401 WHG domain; Region: WHG; pfam13305 1246995007402 Predicted membrane protein [Function unknown]; Region: COG3371 1246995007403 Protein of unknown function (DUF998); Region: DUF998; pfam06197 1246995007404 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1246995007405 cleavage site 1246995007406 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 1246995007407 active site 1246995007408 catalytic triad [active] 1246995007409 oxyanion hole [active] 1246995007410 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1246995007411 hydrophobic ligand binding site; other site 1246995007412 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995007413 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995007414 active site 1246995007415 phosphorylation site [posttranslational modification] 1246995007416 intermolecular recognition site; other site 1246995007417 dimerization interface [polypeptide binding]; other site 1246995007418 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995007419 DNA binding residues [nucleotide binding] 1246995007420 dimerization interface [polypeptide binding]; other site 1246995007421 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1246995007422 Histidine kinase; Region: HisKA_3; pfam07730 1246995007423 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1246995007424 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1246995007425 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 1246995007426 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1246995007427 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1246995007428 putative NAD(P) binding site [chemical binding]; other site 1246995007429 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 1246995007430 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1246995007431 DNA binding residues [nucleotide binding] 1246995007432 putative dimer interface [polypeptide binding]; other site 1246995007433 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 1246995007434 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1246995007435 DXD motif; other site 1246995007436 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1246995007437 lipoyl-biotinyl attachment site [posttranslational modification]; other site 1246995007438 HlyD family secretion protein; Region: HlyD_3; pfam13437 1246995007439 Glycosyl hydrolase family 81; Region: Glyco_hydro_81; cl02310 1246995007440 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 1246995007441 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1246995007442 N-terminal domain of the plant and fungal Nei and related proteins; Region: PF_Nei_N; cd08972 1246995007443 putative DNA binding site [nucleotide binding]; other site 1246995007444 catalytic residue [active] 1246995007445 putative H2TH interface [polypeptide binding]; other site 1246995007446 putative catalytic residues [active] 1246995007447 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1246995007448 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1246995007449 DNA binding site [nucleotide binding] 1246995007450 Bacterial transcriptional activator domain; Region: BTAD; smart01043 1246995007451 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cd00413 1246995007452 active site 1246995007453 catalytic residues [active] 1246995007454 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1246995007455 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 1246995007456 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 1246995007457 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1246995007458 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1246995007459 K+-transporting ATPase, c chain; Region: KdpC; cl00944 1246995007460 K+-transporting ATPase, c chain; Region: KdpC; cl00944 1246995007461 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1246995007462 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 1246995007463 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1246995007464 Ligand Binding Site [chemical binding]; other site 1246995007465 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1246995007466 dimer interface [polypeptide binding]; other site 1246995007467 phosphorylation site [posttranslational modification] 1246995007468 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995007469 ATP binding site [chemical binding]; other site 1246995007470 Mg2+ binding site [ion binding]; other site 1246995007471 G-X-G motif; other site 1246995007472 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1246995007473 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995007474 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995007475 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995007476 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Provisional; Region: PRK06200 1246995007477 NAD(P) binding site [chemical binding]; other site 1246995007478 active site 1246995007479 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1246995007480 salt bridge; other site 1246995007481 non-specific DNA binding site [nucleotide binding]; other site 1246995007482 sequence-specific DNA binding site [nucleotide binding]; other site 1246995007483 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1246995007484 S-adenosylmethionine binding site [chemical binding]; other site 1246995007485 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1246995007486 Formate/glycerate and related dehydrogenases of the D-specific 2-hydroxy acid dehydrogenase family; Region: formate_dh_like; cd05198 1246995007487 ligand binding site [chemical binding]; other site 1246995007488 NAD binding site [chemical binding]; other site 1246995007489 dimerization interface [polypeptide binding]; other site 1246995007490 catalytic site [active] 1246995007491 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1246995007492 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1246995007493 Domain of unknown function (DUF4062); Region: DUF4062; pfam13271 1246995007494 NACHT domain; Region: NACHT; pfam05729 1246995007495 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1246995007496 Walker A motif; other site 1246995007497 ATP binding site [chemical binding]; other site 1246995007498 Walker B motif; other site 1246995007499 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1246995007500 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1246995007501 S-adenosylmethionine binding site [chemical binding]; other site 1246995007502 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995007503 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995007504 Fructosamine kinase; Region: Fructosamin_kin; cl17579 1246995007505 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1246995007506 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1246995007507 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1246995007508 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 1246995007509 Bacterial Ig-like domain; Region: Big_5; pfam13205 1246995007510 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1246995007511 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1246995007512 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1246995007513 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1246995007514 metal binding site [ion binding]; metal-binding site 1246995007515 active site 1246995007516 I-site; other site 1246995007517 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1246995007518 active site 1246995007519 catalytic residues [active] 1246995007520 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995007521 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995007522 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 1246995007523 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cd05188 1246995007524 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1246995007525 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1246995007526 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1246995007527 classical (c) SDRs; Region: SDR_c; cd05233 1246995007528 NAD(P) binding site [chemical binding]; other site 1246995007529 active site 1246995007530 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1246995007531 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1246995007532 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1246995007533 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518 1246995007534 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1246995007535 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995007536 dimer interface [polypeptide binding]; other site 1246995007537 conserved gate region; other site 1246995007538 putative PBP binding loops; other site 1246995007539 ABC-ATPase subunit interface; other site 1246995007540 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1246995007541 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995007542 dimer interface [polypeptide binding]; other site 1246995007543 conserved gate region; other site 1246995007544 putative PBP binding loops; other site 1246995007545 ABC-ATPase subunit interface; other site 1246995007546 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1246995007547 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1246995007548 Walker A/P-loop; other site 1246995007549 ATP binding site [chemical binding]; other site 1246995007550 Q-loop/lid; other site 1246995007551 ABC transporter signature motif; other site 1246995007552 Walker B; other site 1246995007553 D-loop; other site 1246995007554 H-loop/switch region; other site 1246995007555 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1246995007556 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1246995007557 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1246995007558 Walker A/P-loop; other site 1246995007559 ATP binding site [chemical binding]; other site 1246995007560 Q-loop/lid; other site 1246995007561 ABC transporter signature motif; other site 1246995007562 Walker B; other site 1246995007563 D-loop; other site 1246995007564 H-loop/switch region; other site 1246995007565 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 1246995007566 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1246995007567 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995007568 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1246995007569 DNA binding residues [nucleotide binding] 1246995007570 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1246995007571 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 1246995007572 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1246995007573 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 1246995007574 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995007575 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1246995007576 DNA binding residues [nucleotide binding] 1246995007577 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 1246995007578 Protein of unknown function (DUF461); Region: DUF461; pfam04314 1246995007579 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 1246995007580 CopC domain; Region: CopC; pfam04234 1246995007581 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1246995007582 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1246995007583 putative substrate translocation pore; other site 1246995007584 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1246995007585 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1246995007586 Histidine kinase; Region: HisKA_3; pfam07730 1246995007587 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995007588 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995007589 active site 1246995007590 phosphorylation site [posttranslational modification] 1246995007591 intermolecular recognition site; other site 1246995007592 dimerization interface [polypeptide binding]; other site 1246995007593 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995007594 DNA binding residues [nucleotide binding] 1246995007595 dimerization interface [polypeptide binding]; other site 1246995007596 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 1246995007597 potential frameshift: common BLAST hit: gi|152965442|ref|YP_001361226.1| alcohol dehydrogenase GroES domain-containing protein 1246995007598 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1246995007599 potential frameshift: common BLAST hit: gi|386848348|ref|YP_006266361.1| putative signaling protein 1246995007600 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1246995007601 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1246995007602 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 1246995007603 Clostridial hydrophobic W; Region: ChW; pfam07538 1246995007604 Clostridial hydrophobic W; Region: ChW; cl02763 1246995007605 Clostridial hydrophobic W; Region: ChW; pfam07538 1246995007606 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 1246995007607 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 1246995007608 tetramer interface [polypeptide binding]; other site 1246995007609 active site 1246995007610 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 1246995007611 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1246995007612 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1246995007613 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1246995007614 DNA-binding site [nucleotide binding]; DNA binding site 1246995007615 FCD domain; Region: FCD; pfam07729 1246995007616 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1246995007617 Serine hydrolase; Region: Ser_hydrolase; cl17834 1246995007618 UPF0126 domain; Region: UPF0126; pfam03458 1246995007619 Predicted membrane protein [Function unknown]; Region: COG2860 1246995007620 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1246995007621 Coenzyme A binding pocket [chemical binding]; other site 1246995007622 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 1246995007623 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1246995007624 DNA binding residues [nucleotide binding] 1246995007625 drug binding residues [chemical binding]; other site 1246995007626 dimer interface [polypeptide binding]; other site 1246995007627 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 1246995007628 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1246995007629 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1246995007630 HflX GTPase family; Region: HflX; cd01878 1246995007631 G1 box; other site 1246995007632 GTP/Mg2+ binding site [chemical binding]; other site 1246995007633 Switch I region; other site 1246995007634 G2 box; other site 1246995007635 G3 box; other site 1246995007636 Switch II region; other site 1246995007637 G4 box; other site 1246995007638 G5 box; other site 1246995007639 pyruvate dehydrogenase; Provisional; Region: PRK06546 1246995007640 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1246995007641 PYR/PP interface [polypeptide binding]; other site 1246995007642 tetramer interface [polypeptide binding]; other site 1246995007643 dimer interface [polypeptide binding]; other site 1246995007644 TPP binding site [chemical binding]; other site 1246995007645 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1246995007646 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1246995007647 TPP-binding site [chemical binding]; other site 1246995007648 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1246995007649 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1246995007650 metal binding site [ion binding]; metal-binding site 1246995007651 active site 1246995007652 I-site; other site 1246995007653 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1246995007654 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1246995007655 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1246995007656 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1246995007657 Coenzyme A binding pocket [chemical binding]; other site 1246995007658 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1246995007659 homotrimer interaction site [polypeptide binding]; other site 1246995007660 putative active site [active] 1246995007661 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1246995007662 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995007663 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995007664 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1246995007665 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1246995007666 PQQ-like domain; Region: PQQ_2; pfam13360 1246995007667 Trp docking motif [polypeptide binding]; other site 1246995007668 active site 1246995007669 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1246995007670 Zeta-crystallin with NADP-dependent quinone reductase activity (QOR); Region: zeta_crystallin; cd08253 1246995007671 NAD(P) binding site [chemical binding]; other site 1246995007672 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1246995007673 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1246995007674 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 1246995007675 Domain of unknown function (DUF385); Region: DUF385; cl04387 1246995007676 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1246995007677 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1246995007678 Probable transposase; Region: OrfB_IS605; pfam01385 1246995007679 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1246995007680 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1246995007681 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1246995007682 active site 1246995007683 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1246995007684 hydrophobic ligand binding site; other site 1246995007685 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1246995007686 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1246995007687 D-pathway; other site 1246995007688 Putative ubiquinol binding site [chemical binding]; other site 1246995007689 Low-spin heme (heme b) binding site [chemical binding]; other site 1246995007690 Putative water exit pathway; other site 1246995007691 Binuclear center (heme o3/CuB) [ion binding]; other site 1246995007692 K-pathway; other site 1246995007693 Putative proton exit pathway; other site 1246995007694 MMPL family; Region: MMPL; pfam03176 1246995007695 Glucose dehydrogenase; Region: glucose_DH; cd08230 1246995007696 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1246995007697 NADP binding site [chemical binding]; other site 1246995007698 catalytic Zn binding site [ion binding]; other site 1246995007699 structural Zn binding site [ion binding]; other site 1246995007700 dimer interface [polypeptide binding]; other site 1246995007701 Predicted permease; Region: DUF318; cl17795 1246995007702 pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14853 1246995007703 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 1246995007704 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1246995007705 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1246995007706 Walker A/P-loop; other site 1246995007707 ATP binding site [chemical binding]; other site 1246995007708 Q-loop/lid; other site 1246995007709 ABC transporter signature motif; other site 1246995007710 Walker B; other site 1246995007711 D-loop; other site 1246995007712 H-loop/switch region; other site 1246995007713 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1246995007714 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1246995007715 Beta-lactamase; Region: Beta-lactamase; pfam00144 1246995007716 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 1246995007717 Putative cyclase; Region: Cyclase; pfam04199 1246995007718 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1246995007719 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 1246995007720 N- and C-terminal domain interface [polypeptide binding]; other site 1246995007721 active site 1246995007722 catalytic site [active] 1246995007723 metal binding site [ion binding]; metal-binding site 1246995007724 carbohydrate binding site [chemical binding]; other site 1246995007725 ATP binding site [chemical binding]; other site 1246995007726 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 1246995007727 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 1246995007728 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1246995007729 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1246995007730 putative sugar binding sites [chemical binding]; other site 1246995007731 Q-X-W motif; other site 1246995007732 Glycosyl hydrolase catalytic core; Region: Glyco_hydro_cc; pfam11790 1246995007733 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1246995007734 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1246995007735 TPP-binding site; other site 1246995007736 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1246995007737 PYR/PP interface [polypeptide binding]; other site 1246995007738 dimer interface [polypeptide binding]; other site 1246995007739 TPP binding site [chemical binding]; other site 1246995007740 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1246995007741 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1246995007742 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1246995007743 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1246995007744 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1246995007745 putative substrate translocation pore; other site 1246995007746 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1246995007747 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1246995007748 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995007749 dimer interface [polypeptide binding]; other site 1246995007750 conserved gate region; other site 1246995007751 putative PBP binding loops; other site 1246995007752 ABC-ATPase subunit interface; other site 1246995007753 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1246995007754 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995007755 dimer interface [polypeptide binding]; other site 1246995007756 conserved gate region; other site 1246995007757 putative PBP binding loops; other site 1246995007758 ABC-ATPase subunit interface; other site 1246995007759 Protein of unknown function (DUF1348); Region: DUF1348; pfam07080 1246995007760 SnoaL-like domain; Region: SnoaL_2; pfam12680 1246995007761 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 1246995007762 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 1246995007763 CGNR zinc finger; Region: zf-CGNR; pfam11706 1246995007764 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995007765 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 1246995007766 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1246995007767 putative NAD(P) binding site [chemical binding]; other site 1246995007768 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995007769 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995007770 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1246995007771 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995007772 NAD(P) binding site [chemical binding]; other site 1246995007773 active site 1246995007774 RNA polymerase factor sigma-70; Validated; Region: PRK09047 1246995007775 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995007776 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1246995007777 DNA binding residues [nucleotide binding] 1246995007778 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 1246995007779 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 1246995007780 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1246995007781 catalytic loop [active] 1246995007782 iron binding site [ion binding]; other site 1246995007783 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 1246995007784 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1246995007785 beta-galactosidase; Region: BGL; TIGR03356 1246995007786 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1246995007787 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1246995007788 active site 1246995007789 Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270 1246995007790 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1246995007791 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1246995007792 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1246995007793 substrate binding pocket [chemical binding]; other site 1246995007794 dimerization interface [polypeptide binding]; other site 1246995007795 RNA polymerase factor sigma-70; Validated; Region: PRK08241 1246995007796 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995007797 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1246995007798 DNA binding residues [nucleotide binding] 1246995007799 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1246995007800 GAF domain; Region: GAF; pfam01590 1246995007801 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1246995007802 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1246995007803 GAF domain; Region: GAF; pfam01590 1246995007804 ANTAR domain; Region: ANTAR; pfam03861 1246995007805 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1246995007806 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1246995007807 salt bridge; other site 1246995007808 non-specific DNA binding site [nucleotide binding]; other site 1246995007809 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1246995007810 sequence-specific DNA binding site [nucleotide binding]; other site 1246995007811 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 1246995007812 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1246995007813 catalytic Zn binding site [ion binding]; other site 1246995007814 NAD(P) binding site [chemical binding]; other site 1246995007815 structural Zn binding site [ion binding]; other site 1246995007816 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1246995007817 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1246995007818 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1246995007819 Uncharacterized conserved protein [Function unknown]; Region: COG4925 1246995007820 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1246995007821 DNA-binding site [nucleotide binding]; DNA binding site 1246995007822 RNA-binding motif; other site 1246995007823 RibD C-terminal domain; Region: RibD_C; cl17279 1246995007824 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1246995007825 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1246995007826 AAA ATPase domain; Region: AAA_16; pfam13191 1246995007827 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995007828 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995007829 DNA binding residues [nucleotide binding] 1246995007830 dimerization interface [polypeptide binding]; other site 1246995007831 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1246995007832 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1246995007833 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1246995007834 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1246995007835 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1246995007836 MarR family; Region: MarR_2; cl17246 1246995007837 Cupin; Region: Cupin_6; pfam12852 1246995007838 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1246995007839 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1246995007840 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1246995007841 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1246995007842 active site 1246995007843 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 1246995007844 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1246995007845 Walker A/P-loop; other site 1246995007846 ATP binding site [chemical binding]; other site 1246995007847 Q-loop/lid; other site 1246995007848 ABC transporter signature motif; other site 1246995007849 Walker B; other site 1246995007850 D-loop; other site 1246995007851 H-loop/switch region; other site 1246995007852 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1246995007853 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1246995007854 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1246995007855 Walker A/P-loop; other site 1246995007856 ATP binding site [chemical binding]; other site 1246995007857 Q-loop/lid; other site 1246995007858 ABC transporter signature motif; other site 1246995007859 Walker B; other site 1246995007860 D-loop; other site 1246995007861 H-loop/switch region; other site 1246995007862 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1246995007863 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1246995007864 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995007865 dimer interface [polypeptide binding]; other site 1246995007866 ABC-ATPase subunit interface; other site 1246995007867 putative PBP binding loops; other site 1246995007868 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1246995007869 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995007870 dimer interface [polypeptide binding]; other site 1246995007871 conserved gate region; other site 1246995007872 putative PBP binding loops; other site 1246995007873 ABC-ATPase subunit interface; other site 1246995007874 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1246995007875 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1246995007876 peptide binding site [polypeptide binding]; other site 1246995007877 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1246995007878 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1246995007879 acyl-activating enzyme (AAE) consensus motif; other site 1246995007880 putative AMP binding site [chemical binding]; other site 1246995007881 putative active site [active] 1246995007882 putative CoA binding site [chemical binding]; other site 1246995007883 Domain of unknown function (DUF4291); Region: DUF4291; pfam14124 1246995007884 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 1246995007885 Chromate transporter; Region: Chromate_transp; pfam02417 1246995007886 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1246995007887 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 1246995007888 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 1246995007889 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1246995007890 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1246995007891 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1246995007892 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1246995007893 GAF domain; Region: GAF; pfam01590 1246995007894 ANTAR domain; Region: ANTAR; pfam03861 1246995007895 FAD binding domain; Region: FAD_binding_3; pfam01494 1246995007896 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1246995007897 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1246995007898 Protein of unknown function (DUF419); Region: DUF419; pfam04237 1246995007899 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1246995007900 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995007901 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995007902 Epoxide hydrolase N terminus; Region: EHN; pfam06441 1246995007903 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1246995007904 Agrobacterium tumefaciens protein Atu4866; Region: Atu4866; pfam11512 1246995007905 AAA ATPase domain; Region: AAA_16; pfam13191 1246995007906 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995007907 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995007908 DNA binding residues [nucleotide binding] 1246995007909 dimerization interface [polypeptide binding]; other site 1246995007910 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995007911 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995007912 WHG domain; Region: WHG; pfam13305 1246995007913 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1246995007914 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1246995007915 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1246995007916 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR8; cd08273 1246995007917 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1246995007918 putative NAD(P) binding site [chemical binding]; other site 1246995007919 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_like_4; cd06152 1246995007920 homotrimer interaction site [polypeptide binding]; other site 1246995007921 putative active site [active] 1246995007922 short chain dehydrogenase; Validated; Region: PRK08264 1246995007923 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995007924 NAD(P) binding site [chemical binding]; other site 1246995007925 active site 1246995007926 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 1246995007927 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1246995007928 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1246995007929 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1246995007930 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1246995007931 RibD C-terminal domain; Region: RibD_C; cl17279 1246995007932 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_1; cd08894 1246995007933 putative hydrophobic ligand binding site [chemical binding]; other site 1246995007934 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1246995007935 dimerization interface [polypeptide binding]; other site 1246995007936 putative DNA binding site [nucleotide binding]; other site 1246995007937 putative Zn2+ binding site [ion binding]; other site 1246995007938 Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457 1246995007939 CBD_II domain; Region: CBD_II; smart00637 1246995007940 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1246995007941 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1246995007942 putative sugar binding sites [chemical binding]; other site 1246995007943 Q-X-W motif; other site 1246995007944 Glycosyl hydrolase family 62; Region: Glyco_hydro_62; pfam03664 1246995007945 active site 1246995007946 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1246995007947 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1246995007948 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1246995007949 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995007950 dimer interface [polypeptide binding]; other site 1246995007951 conserved gate region; other site 1246995007952 putative PBP binding loops; other site 1246995007953 ABC-ATPase subunit interface; other site 1246995007954 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1246995007955 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995007956 dimer interface [polypeptide binding]; other site 1246995007957 conserved gate region; other site 1246995007958 putative PBP binding loops; other site 1246995007959 ABC-ATPase subunit interface; other site 1246995007960 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1246995007961 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1246995007962 DoxX-like family; Region: DoxX_2; pfam13564 1246995007963 Histidine kinase; Region: HisKA_3; pfam07730 1246995007964 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995007965 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995007966 active site 1246995007967 phosphorylation site [posttranslational modification] 1246995007968 intermolecular recognition site; other site 1246995007969 dimerization interface [polypeptide binding]; other site 1246995007970 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995007971 DNA binding residues [nucleotide binding] 1246995007972 dimerization interface [polypeptide binding]; other site 1246995007973 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 1246995007974 Protein of unknown function (DUF1059); Region: DUF1059; cl02284 1246995007975 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995007976 short chain dehydrogenase; Provisional; Region: PRK06197 1246995007977 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1246995007978 putative NAD(P) binding site [chemical binding]; other site 1246995007979 active site 1246995007980 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1246995007981 active site 1246995007982 ATP binding site [chemical binding]; other site 1246995007983 Protein kinase domain; Region: Pkinase; pfam00069 1246995007984 substrate binding site [chemical binding]; other site 1246995007985 activation loop (A-loop); other site 1246995007986 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1246995007987 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1246995007988 putative NAD(P) binding site [chemical binding]; other site 1246995007989 Helix-turn-helix domain; Region: HTH_31; pfam13560 1246995007990 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1246995007991 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1246995007992 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1246995007993 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1246995007994 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1246995007995 Predicted ATPase [General function prediction only]; Region: COG3899 1246995007996 AAA ATPase domain; Region: AAA_16; pfam13191 1246995007997 Helix-turn-helix domain; Region: HTH_18; pfam12833 1246995007998 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1246995007999 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1246995008000 short chain dehydrogenase; Provisional; Region: PRK05854 1246995008001 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995008002 NAD(P) binding site [chemical binding]; other site 1246995008003 active site 1246995008004 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1246995008005 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1246995008006 sequence-specific DNA binding site [nucleotide binding]; other site 1246995008007 salt bridge; other site 1246995008008 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 1246995008009 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1246995008010 CBD_II domain; Region: CBD_II; smart00637 1246995008011 Cellulose binding domain; Region: CBM_2; pfam00553 1246995008012 Glycosyl hydrolase family 62; Region: Glyco_hydro_62; pfam03664 1246995008013 active site 1246995008014 Cellulose binding domain; Region: CBM_2; pfam00553 1246995008015 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1246995008016 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 1246995008017 active site 1246995008018 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 1246995008019 CBD_II domain; Region: CBD_II; smart00637 1246995008020 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1246995008021 Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270 1246995008022 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1246995008023 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1246995008024 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1246995008025 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1246995008026 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1246995008027 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1246995008028 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1246995008029 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1246995008030 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1246995008031 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1246995008032 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995008033 Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270 1246995008034 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1246995008035 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1246995008036 active site 1246995008037 ATP binding site [chemical binding]; other site 1246995008038 substrate binding site [chemical binding]; other site 1246995008039 activation loop (A-loop); other site 1246995008040 MarR family; Region: MarR_2; pfam12802 1246995008041 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1246995008042 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1246995008043 nucleotide binding site [chemical binding]; other site 1246995008044 Melibiase; Region: Melibiase; pfam02065 1246995008045 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1246995008046 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1246995008047 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1246995008048 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995008049 dimer interface [polypeptide binding]; other site 1246995008050 conserved gate region; other site 1246995008051 putative PBP binding loops; other site 1246995008052 ABC-ATPase subunit interface; other site 1246995008053 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995008054 dimer interface [polypeptide binding]; other site 1246995008055 conserved gate region; other site 1246995008056 putative PBP binding loops; other site 1246995008057 ABC-ATPase subunit interface; other site 1246995008058 Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081 1246995008059 Ca binding site [ion binding]; other site 1246995008060 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 1246995008061 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 1246995008062 dimer interface [polypeptide binding]; other site 1246995008063 active site 1246995008064 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 1246995008065 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 1246995008066 putative metal binding site [ion binding]; other site 1246995008067 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1246995008068 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1246995008069 putative sugar binding sites [chemical binding]; other site 1246995008070 Q-X-W motif; other site 1246995008071 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 1246995008072 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 1246995008073 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 1246995008074 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 1246995008075 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1246995008076 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1246995008077 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1246995008078 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1246995008079 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 1246995008080 Kelch motif; Region: Kelch_1; pfam01344 1246995008081 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 1246995008082 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 1246995008083 Kelch domain; Region: Kelch; smart00612 1246995008084 Kelch motif; Region: Kelch_1; pfam01344 1246995008085 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 1246995008086 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1246995008087 MarR family; Region: MarR_2; pfam12802 1246995008088 Epoxide hydrolase N terminus; Region: EHN; pfam06441 1246995008089 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1246995008090 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1246995008091 HAMP domain; Region: HAMP; pfam00672 1246995008092 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1246995008093 dimer interface [polypeptide binding]; other site 1246995008094 phosphorylation site [posttranslational modification] 1246995008095 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995008096 ATP binding site [chemical binding]; other site 1246995008097 Mg2+ binding site [ion binding]; other site 1246995008098 G-X-G motif; other site 1246995008099 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1246995008100 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995008101 active site 1246995008102 phosphorylation site [posttranslational modification] 1246995008103 intermolecular recognition site; other site 1246995008104 dimerization interface [polypeptide binding]; other site 1246995008105 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1246995008106 DNA binding site [nucleotide binding] 1246995008107 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995008108 heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189 1246995008109 Walker A/P-loop; other site 1246995008110 ATP binding site [chemical binding]; other site 1246995008111 Q-loop/lid; other site 1246995008112 ABC transporter signature motif; other site 1246995008113 Walker B; other site 1246995008114 D-loop; other site 1246995008115 H-loop/switch region; other site 1246995008116 Protein of unknown function (DUF1349); Region: DUF1349; cl01397 1246995008117 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 1246995008118 YCII-related domain; Region: YCII; cl00999 1246995008119 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1246995008120 active site 1246995008121 tetramer interface [polypeptide binding]; other site 1246995008122 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1246995008123 classical (c) SDRs; Region: SDR_c; cd05233 1246995008124 NAD(P) binding site [chemical binding]; other site 1246995008125 active site 1246995008126 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1246995008127 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1246995008128 active site 1246995008129 catalytic tetrad [active] 1246995008130 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1246995008131 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1246995008132 putative NAD(P) binding site [chemical binding]; other site 1246995008133 putative substrate binding site [chemical binding]; other site 1246995008134 catalytic Zn binding site [ion binding]; other site 1246995008135 structural Zn binding site [ion binding]; other site 1246995008136 dimer interface [polypeptide binding]; other site 1246995008137 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995008138 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1246995008139 NAD(P) binding site [chemical binding]; other site 1246995008140 active site 1246995008141 Predicted transcriptional regulators [Transcription]; Region: COG1733 1246995008142 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1246995008143 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995008144 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995008145 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 1246995008146 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1246995008147 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995008148 Walker A/P-loop; other site 1246995008149 ATP binding site [chemical binding]; other site 1246995008150 Q-loop/lid; other site 1246995008151 ABC transporter signature motif; other site 1246995008152 Walker B; other site 1246995008153 D-loop; other site 1246995008154 H-loop/switch region; other site 1246995008155 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 1246995008156 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1246995008157 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1246995008158 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1246995008159 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1246995008160 intermolecular salt bridges; other site 1246995008161 calcium mediated ligand binding site; other site 1246995008162 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1246995008163 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1246995008164 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1246995008165 dimerization interface [polypeptide binding]; other site 1246995008166 Uncharacterized protein conserved in bacteria (DUF2255); Region: DUF2255; cl01788 1246995008167 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1246995008168 amidase catalytic site [active] 1246995008169 Zn binding residues [ion binding]; other site 1246995008170 substrate binding site [chemical binding]; other site 1246995008171 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354 1246995008172 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1246995008173 substrate binding site [chemical binding]; other site 1246995008174 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1246995008175 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1246995008176 DNA-binding site [nucleotide binding]; DNA binding site 1246995008177 FCD domain; Region: FCD; pfam07729 1246995008178 Predicted transcriptional regulator [Transcription]; Region: COG2378 1246995008179 WYL domain; Region: WYL; pfam13280 1246995008180 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1246995008181 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1246995008182 active site 1246995008183 metal binding site [ion binding]; metal-binding site 1246995008184 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 1246995008185 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 1246995008186 active site 1246995008187 nucleophile elbow; other site 1246995008188 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 1246995008189 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1246995008190 Domain of unknown function (DUF756); Region: DUF756; pfam05506 1246995008191 spore photoproduct lyase; Region: photo_TT_lyase; cl15393 1246995008192 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 1246995008193 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1246995008194 Strictosidine synthase; Region: Str_synth; pfam03088 1246995008195 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 1246995008196 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1246995008197 S-adenosylmethionine binding site [chemical binding]; other site 1246995008198 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1246995008199 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1246995008200 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1246995008201 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 1246995008202 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1246995008203 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1246995008204 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1246995008205 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 1246995008206 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995008207 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1246995008208 DNA binding residues [nucleotide binding] 1246995008209 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1246995008210 metal binding site 2 [ion binding]; metal-binding site 1246995008211 putative DNA binding helix; other site 1246995008212 metal binding site 1 [ion binding]; metal-binding site 1246995008213 dimer interface [polypeptide binding]; other site 1246995008214 structural Zn2+ binding site [ion binding]; other site 1246995008215 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 1246995008216 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 1246995008217 heme binding site [chemical binding]; other site 1246995008218 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 1246995008219 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1246995008220 Predicted transcriptional regulators [Transcription]; Region: COG1733 1246995008221 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1246995008222 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 1246995008223 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1246995008224 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1246995008225 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995008226 dimer interface [polypeptide binding]; other site 1246995008227 conserved gate region; other site 1246995008228 putative PBP binding loops; other site 1246995008229 ABC-ATPase subunit interface; other site 1246995008230 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1246995008231 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995008232 dimer interface [polypeptide binding]; other site 1246995008233 conserved gate region; other site 1246995008234 putative PBP binding loops; other site 1246995008235 ABC-ATPase subunit interface; other site 1246995008236 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1246995008237 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1246995008238 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1246995008239 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1246995008240 ligand binding site [chemical binding]; other site 1246995008241 dimerization interface [polypeptide binding]; other site 1246995008242 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1246995008243 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1246995008244 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1246995008245 nucleotide binding site [chemical binding]; other site 1246995008246 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1246995008247 Protein of unknown function (DUF998); Region: DUF998; pfam06197 1246995008248 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1246995008249 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1246995008250 salt bridge; other site 1246995008251 non-specific DNA binding site [nucleotide binding]; other site 1246995008252 sequence-specific DNA binding site [nucleotide binding]; other site 1246995008253 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1246995008254 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 1246995008255 putative NAD(P) binding site [chemical binding]; other site 1246995008256 Part of AAA domain; Region: AAA_19; pfam13245 1246995008257 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 1246995008258 AAA domain; Region: AAA_12; pfam13087 1246995008259 Transglycosylase; Region: Transgly; pfam00912 1246995008260 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1246995008261 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1246995008262 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1246995008263 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1246995008264 sequence-specific DNA binding site [nucleotide binding]; other site 1246995008265 salt bridge; other site 1246995008266 Hemerythrin-like domain; Region: Hr-like; cd12108 1246995008267 Transmembrane secretion effector; Region: MFS_3; pfam05977 1246995008268 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1246995008269 putative substrate translocation pore; other site 1246995008270 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1246995008271 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1246995008272 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995008273 Walker A/P-loop; other site 1246995008274 ATP binding site [chemical binding]; other site 1246995008275 Q-loop/lid; other site 1246995008276 ABC transporter signature motif; other site 1246995008277 Walker B; other site 1246995008278 D-loop; other site 1246995008279 H-loop/switch region; other site 1246995008280 Domain of unknown function (DUF389); Region: DUF389; cl00781 1246995008281 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1246995008282 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1246995008283 metal binding site [ion binding]; metal-binding site 1246995008284 active site 1246995008285 I-site; other site 1246995008286 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1246995008287 active site 1246995008288 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1246995008289 putative catalytic site [active] 1246995008290 putative metal binding site [ion binding]; other site 1246995008291 putative phosphate binding site [ion binding]; other site 1246995008292 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1246995008293 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1246995008294 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1246995008295 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1246995008296 dimerization interface [polypeptide binding]; other site 1246995008297 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1246995008298 dimer interface [polypeptide binding]; other site 1246995008299 phosphorylation site [posttranslational modification] 1246995008300 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995008301 ATP binding site [chemical binding]; other site 1246995008302 Mg2+ binding site [ion binding]; other site 1246995008303 G-X-G motif; other site 1246995008304 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1246995008305 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995008306 active site 1246995008307 phosphorylation site [posttranslational modification] 1246995008308 intermolecular recognition site; other site 1246995008309 dimerization interface [polypeptide binding]; other site 1246995008310 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1246995008311 DNA binding site [nucleotide binding] 1246995008312 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1246995008313 Predicted peptidase [General function prediction only]; Region: COG4099 1246995008314 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1246995008315 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 1246995008316 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1246995008317 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1246995008318 NADP binding site [chemical binding]; other site 1246995008319 active site 1246995008320 steroid binding site; other site 1246995008321 short chain dehydrogenase; Provisional; Region: PRK12937 1246995008322 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 1246995008323 NADP binding site [chemical binding]; other site 1246995008324 homodimer interface [polypeptide binding]; other site 1246995008325 active site 1246995008326 substrate binding site [chemical binding]; other site 1246995008327 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1246995008328 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1246995008329 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1246995008330 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1246995008331 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1246995008332 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1246995008333 dimerization interface [polypeptide binding]; other site 1246995008334 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1246995008335 dimer interface [polypeptide binding]; other site 1246995008336 putative CheW interface [polypeptide binding]; other site 1246995008337 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995008338 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995008339 SGNH_hydrolase subfamily, similar to Ruminococcus flavefaciens XynB. Most likely a secreted hydrolase with xylanase activity. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from...; Region: XynB_like; cd01833 1246995008340 active site 1246995008341 catalytic triad [active] 1246995008342 oxyanion hole [active] 1246995008343 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1246995008344 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1246995008345 putative sugar binding sites [chemical binding]; other site 1246995008346 Q-X-W motif; other site 1246995008347 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 1246995008348 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 1246995008349 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 1246995008350 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 1246995008351 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1246995008352 Domain of unknown function (DUF4279); Region: DUF4279; pfam14106 1246995008353 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1246995008354 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 1246995008355 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995008356 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1246995008357 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1246995008358 acyl-activating enzyme (AAE) consensus motif; other site 1246995008359 AMP binding site [chemical binding]; other site 1246995008360 active site 1246995008361 CoA binding site [chemical binding]; other site 1246995008362 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1246995008363 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 1246995008364 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1246995008365 putative trimer interface [polypeptide binding]; other site 1246995008366 putative CoA binding site [chemical binding]; other site 1246995008367 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 1246995008368 Zn binding site [ion binding]; other site 1246995008369 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 1246995008370 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 1246995008371 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 1246995008372 putative metal binding site [ion binding]; other site 1246995008373 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 1246995008374 spore photoproduct lyase family protein; Region: lyase_spl_fam; TIGR03886 1246995008375 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 1246995008376 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1246995008377 MarR family; Region: MarR_2; pfam12802 1246995008378 MarR family; Region: MarR_2; cl17246 1246995008379 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1246995008380 hypothetical protein; Provisional; Region: PRK07877 1246995008381 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 1246995008382 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1246995008383 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 1246995008384 Glycosyl hydrolase family 43, includes mostly 1,4-beta-xylanases; Region: GH43_bXyl; cd09004 1246995008385 putative substrate binding site [chemical binding]; other site 1246995008386 active site 1246995008387 PQQ-like domain; Region: PQQ_2; pfam13360 1246995008388 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1246995008389 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 1246995008390 short chain dehydrogenase; Provisional; Region: PRK06197 1246995008391 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995008392 NAD(P) binding site [chemical binding]; other site 1246995008393 active site 1246995008394 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1246995008395 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995008396 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1246995008397 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1246995008398 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1246995008399 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1246995008400 sugar binding site [chemical binding]; other site 1246995008401 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1246995008402 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1246995008403 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 1246995008404 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 1246995008405 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1246995008406 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1246995008407 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1246995008408 S-adenosylmethionine binding site [chemical binding]; other site 1246995008409 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1246995008410 classical (c) SDRs; Region: SDR_c; cd05233 1246995008411 NAD(P) binding site [chemical binding]; other site 1246995008412 active site 1246995008413 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1246995008414 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1246995008415 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 1246995008416 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1246995008417 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1246995008418 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1246995008419 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1246995008420 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1246995008421 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1246995008422 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995008423 Walker A/P-loop; other site 1246995008424 ATP binding site [chemical binding]; other site 1246995008425 Q-loop/lid; other site 1246995008426 ABC transporter signature motif; other site 1246995008427 Walker B; other site 1246995008428 D-loop; other site 1246995008429 H-loop/switch region; other site 1246995008430 TOBE domain; Region: TOBE_2; pfam08402 1246995008431 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995008432 dimer interface [polypeptide binding]; other site 1246995008433 conserved gate region; other site 1246995008434 putative PBP binding loops; other site 1246995008435 ABC-ATPase subunit interface; other site 1246995008436 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1246995008437 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995008438 dimer interface [polypeptide binding]; other site 1246995008439 conserved gate region; other site 1246995008440 putative PBP binding loops; other site 1246995008441 ABC-ATPase subunit interface; other site 1246995008442 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1246995008443 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1246995008444 Bacterial transcriptional regulator; Region: IclR; pfam01614 1246995008445 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1246995008446 classical (c) SDRs; Region: SDR_c; cd05233 1246995008447 NAD(P) binding site [chemical binding]; other site 1246995008448 active site 1246995008449 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 1246995008450 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1246995008451 PYR/PP interface [polypeptide binding]; other site 1246995008452 dimer interface [polypeptide binding]; other site 1246995008453 TPP binding site [chemical binding]; other site 1246995008454 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1246995008455 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1246995008456 TPP-binding site [chemical binding]; other site 1246995008457 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1246995008458 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1246995008459 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1246995008460 DNA-binding site [nucleotide binding]; DNA binding site 1246995008461 FCD domain; Region: FCD; pfam07729 1246995008462 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1246995008463 Cupin domain; Region: Cupin_2; cl17218 1246995008464 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1246995008465 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1246995008466 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1246995008467 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1246995008468 active site 1246995008469 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1246995008470 classical (c) SDRs; Region: SDR_c; cd05233 1246995008471 NAD(P) binding site [chemical binding]; other site 1246995008472 active site 1246995008473 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1246995008474 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1246995008475 tetramerization interface [polypeptide binding]; other site 1246995008476 NAD(P) binding site [chemical binding]; other site 1246995008477 catalytic residues [active] 1246995008478 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1246995008479 active site 1246995008480 substrate binding site [chemical binding]; other site 1246995008481 ATP binding site [chemical binding]; other site 1246995008482 Phosphotransferase enzyme family; Region: APH; pfam01636 1246995008483 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1246995008484 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1246995008485 putative substrate translocation pore; other site 1246995008486 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 1246995008487 CGNR zinc finger; Region: zf-CGNR; pfam11706 1246995008488 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1246995008489 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1246995008490 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1246995008491 dimerization interface [polypeptide binding]; other site 1246995008492 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1246995008493 S-adenosylmethionine binding site [chemical binding]; other site 1246995008494 Amb_all domain; Region: Amb_all; smart00656 1246995008495 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1246995008496 Endonuclease I; Region: Endonuclease_1; pfam04231 1246995008497 Arginase-like amidino hydrolase family; Region: Arginase-like_1; cd09999 1246995008498 active site 1246995008499 Mn binding site [ion binding]; other site 1246995008500 Family description; Region: VCBS; pfam13517 1246995008501 RHS Repeat; Region: RHS_repeat; pfam05593 1246995008502 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1246995008503 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1246995008504 putative sugar binding sites [chemical binding]; other site 1246995008505 Q-X-W motif; other site 1246995008506 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1246995008507 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1246995008508 protein-splicing catalytic site; other site 1246995008509 thioester formation/cholesterol transfer; other site 1246995008510 Pretoxin HINT domain; Region: PT-HINT; pfam07591 1246995008511 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1246995008512 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 1246995008513 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1246995008514 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1246995008515 active site 1246995008516 catalytic tetrad [active] 1246995008517 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995008518 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995008519 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1246995008520 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 1246995008521 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 1246995008522 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1246995008523 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1246995008524 PAS domain; Region: PAS; smart00091 1246995008525 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995008526 ATP binding site [chemical binding]; other site 1246995008527 Mg2+ binding site [ion binding]; other site 1246995008528 G-X-G motif; other site 1246995008529 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1246995008530 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995008531 active site 1246995008532 phosphorylation site [posttranslational modification] 1246995008533 intermolecular recognition site; other site 1246995008534 dimerization interface [polypeptide binding]; other site 1246995008535 NB-ARC domain; Region: NB-ARC; pfam00931 1246995008536 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1246995008537 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1246995008538 binding surface 1246995008539 TPR motif; other site 1246995008540 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1246995008541 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1246995008542 binding surface 1246995008543 TPR motif; other site 1246995008544 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1246995008545 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1246995008546 putative trimer interface [polypeptide binding]; other site 1246995008547 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 1246995008548 putative CoA binding site [chemical binding]; other site 1246995008549 putative trimer interface [polypeptide binding]; other site 1246995008550 putative active site [active] 1246995008551 putative substrate binding site [chemical binding]; other site 1246995008552 putative CoA binding site [chemical binding]; other site 1246995008553 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1246995008554 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1246995008555 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1246995008556 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995008557 NAD(P) binding site [chemical binding]; other site 1246995008558 active site 1246995008559 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1246995008560 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1246995008561 inhibitor-cofactor binding pocket; inhibition site 1246995008562 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1246995008563 catalytic residue [active] 1246995008564 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 1246995008565 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 1246995008566 putative trimer interface [polypeptide binding]; other site 1246995008567 putative CoA binding site [chemical binding]; other site 1246995008568 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1246995008569 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1246995008570 inhibitor-cofactor binding pocket; inhibition site 1246995008571 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1246995008572 catalytic residue [active] 1246995008573 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1246995008574 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1246995008575 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1246995008576 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 1246995008577 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1246995008578 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 1246995008579 Bacterial Ig-like domain; Region: Big_5; pfam13205 1246995008580 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 1246995008581 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 1246995008582 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 1246995008583 pyridoxal-dependent decarboxylase, exosortase A system-associated; Region: dCO2ase_PEP1; TIGR03099 1246995008584 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Btrk Decarboxylase; Region: PLPDE_III_Btrk_like; cd06839 1246995008585 dimer interface [polypeptide binding]; other site 1246995008586 active site 1246995008587 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1246995008588 catalytic residues [active] 1246995008589 substrate binding site [chemical binding]; other site 1246995008590 acyl-CoA ligase (AMP-forming), exosortase A-associated; Region: ligase_PEP_1; TIGR03098 1246995008591 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1246995008592 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_6; cd05922 1246995008593 acyl-activating enzyme (AAE) consensus motif; other site 1246995008594 acyl-activating enzyme (AAE) consensus motif; other site 1246995008595 putative AMP binding site [chemical binding]; other site 1246995008596 putative active site [active] 1246995008597 putative CoA binding site [chemical binding]; other site 1246995008598 Right handed beta helix region; Region: Beta_helix; pfam13229 1246995008599 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1246995008600 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1246995008601 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995008602 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1246995008603 Walker A/P-loop; other site 1246995008604 ATP binding site [chemical binding]; other site 1246995008605 Q-loop/lid; other site 1246995008606 ABC transporter signature motif; other site 1246995008607 Walker B; other site 1246995008608 D-loop; other site 1246995008609 H-loop/switch region; other site 1246995008610 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1246995008611 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1246995008612 active site 1246995008613 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1246995008614 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1246995008615 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 1246995008616 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 1246995008617 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 1246995008618 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1246995008619 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1246995008620 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1246995008621 active site 1246995008622 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1246995008623 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1246995008624 putative active site [active] 1246995008625 putative metal binding site [ion binding]; other site 1246995008626 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1246995008627 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1246995008628 active site 1246995008629 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1246995008630 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1246995008631 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1246995008632 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1246995008633 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1246995008634 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 1246995008635 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1246995008636 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1246995008637 substrate binding site; other site 1246995008638 tetramer interface; other site 1246995008639 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1246995008640 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1246995008641 NAD binding site [chemical binding]; other site 1246995008642 substrate binding site [chemical binding]; other site 1246995008643 homodimer interface [polypeptide binding]; other site 1246995008644 active site 1246995008645 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1246995008646 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 1246995008647 NADP binding site [chemical binding]; other site 1246995008648 active site 1246995008649 putative substrate binding site [chemical binding]; other site 1246995008650 Possible enoyl reductase; Region: MDR_enoyl_red; cd08244 1246995008651 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1246995008652 putative NAD(P) binding site [chemical binding]; other site 1246995008653 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 1246995008654 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1246995008655 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1246995008656 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 1246995008657 active site 1246995008658 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 1246995008659 active site 1246995008660 Fe binding site [ion binding]; other site 1246995008661 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 1246995008662 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995008663 shikimate 5-dehydrogenase; Reviewed; Region: PRK12549 1246995008664 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1246995008665 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1246995008666 shikimate binding site; other site 1246995008667 NAD(P) binding site [chemical binding]; other site 1246995008668 H+ Antiporter protein; Region: 2A0121; TIGR00900 1246995008669 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1246995008670 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1246995008671 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1246995008672 dimerization interface [polypeptide binding]; other site 1246995008673 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1246995008674 dimerization interface [polypeptide binding]; other site 1246995008675 putative DNA binding site [nucleotide binding]; other site 1246995008676 putative Zn2+ binding site [ion binding]; other site 1246995008677 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1246995008678 hydrophobic ligand binding site; other site 1246995008679 TIGR03086 family protein; Region: TIGR03086 1246995008680 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1246995008681 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1246995008682 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1246995008683 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 1246995008684 NAD(P) binding pocket [chemical binding]; other site 1246995008685 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1246995008686 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1246995008687 putative DNA binding site [nucleotide binding]; other site 1246995008688 putative Zn2+ binding site [ion binding]; other site 1246995008689 AsnC family; Region: AsnC_trans_reg; pfam01037 1246995008690 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1246995008691 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1246995008692 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1246995008693 catalytic residue [active] 1246995008694 CopC domain; Region: CopC; cl01012 1246995008695 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995008696 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995008697 active site 1246995008698 phosphorylation site [posttranslational modification] 1246995008699 intermolecular recognition site; other site 1246995008700 dimerization interface [polypeptide binding]; other site 1246995008701 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995008702 DNA binding residues [nucleotide binding] 1246995008703 dimerization interface [polypeptide binding]; other site 1246995008704 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1246995008705 Histidine kinase; Region: HisKA_3; pfam07730 1246995008706 MMPL family; Region: MMPL; pfam03176 1246995008707 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1246995008708 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1246995008709 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1246995008710 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1246995008711 active site 1246995008712 catalytic site [active] 1246995008713 Uncharacterized hypothetical proteins similar to the catalytic domains of Phosphoinositide-specific phospholipaseand Glycerophosphodiester phosphodiesterases; Region: PI-PLCc_GDPD_SF_unchar3; cd08577 1246995008714 putative active site [active] 1246995008715 catalytic site [active] 1246995008716 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1246995008717 active site 1246995008718 substrate binding site [chemical binding]; other site 1246995008719 ATP binding site [chemical binding]; other site 1246995008720 activation loop (A-loop); other site 1246995008721 Bulb-type mannose-specific lectin; Region: B_lectin; smart00108 1246995008722 Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028 1246995008723 dimerization interface [polypeptide binding]; other site 1246995008724 mannose binding site [chemical binding]; other site 1246995008725 C-type lysozyme (1, 4-beta-N-acetylmuramidase, LYZ) and alpha-lactalbumin (lactose synthase B protein, LA). They have a close evolutionary relationship and similar tertiary structure, however, functionally they are quite different. Lysozymes have...; Region: LYZ1; cl17441 1246995008726 lysozyme catalytic cleft [active] 1246995008727 lysozyme catalytic site [active] 1246995008728 Ca2+ binding site [ion binding]; other site 1246995008729 Bulb-type mannose-specific lectin; Region: B_lectin; smart00108 1246995008730 Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028 1246995008731 dimerization interface [polypeptide binding]; other site 1246995008732 mannose binding site [chemical binding]; other site 1246995008733 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1246995008734 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1246995008735 active site 1246995008736 catalytic tetrad [active] 1246995008737 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 1246995008738 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 1246995008739 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 1246995008740 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 1246995008741 putative ligand binding site [chemical binding]; other site 1246995008742 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1246995008743 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1246995008744 Walker A/P-loop; other site 1246995008745 ATP binding site [chemical binding]; other site 1246995008746 Q-loop/lid; other site 1246995008747 ABC transporter signature motif; other site 1246995008748 Walker B; other site 1246995008749 D-loop; other site 1246995008750 H-loop/switch region; other site 1246995008751 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1246995008752 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1246995008753 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1246995008754 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1246995008755 TM-ABC transporter signature motif; other site 1246995008756 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1246995008757 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1246995008758 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1246995008759 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 1246995008760 GAF domain; Region: GAF_2; pfam13185 1246995008761 GAF domain; Region: GAF; cl17456 1246995008762 Histidine kinase; Region: HisKA_3; pfam07730 1246995008763 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1246995008764 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995008765 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995008766 active site 1246995008767 phosphorylation site [posttranslational modification] 1246995008768 intermolecular recognition site; other site 1246995008769 dimerization interface [polypeptide binding]; other site 1246995008770 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995008771 DNA binding residues [nucleotide binding] 1246995008772 dimerization interface [polypeptide binding]; other site 1246995008773 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 1246995008774 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995008775 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1246995008776 hypothetical protein; Provisional; Region: PRK07236 1246995008777 FAD binding domain; Region: FAD_binding_3; pfam01494 1246995008778 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1246995008779 Protein of unknown function (DUF2927); Region: DUF2927; pfam11150 1246995008780 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1246995008781 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1246995008782 metal ion-dependent adhesion site (MIDAS); other site 1246995008783 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1246995008784 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1246995008785 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 1246995008786 Walker A motif; other site 1246995008787 ATP binding site [chemical binding]; other site 1246995008788 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 1246995008789 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1246995008790 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1246995008791 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1246995008792 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1246995008793 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1246995008794 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1246995008795 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 1246995008796 putative dimerization interface [polypeptide binding]; other site 1246995008797 short chain dehydrogenase; Provisional; Region: PRK08263 1246995008798 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1246995008799 NADP binding site [chemical binding]; other site 1246995008800 active site 1246995008801 steroid binding site; other site 1246995008802 CBD_II domain; Region: CBD_II; smart00637 1246995008803 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 1246995008804 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 1246995008805 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1246995008806 DAK2 domain; Region: Dak2; cl03685 1246995008807 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 1246995008808 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 1246995008809 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1246995008810 dimerization domain swap beta strand [polypeptide binding]; other site 1246995008811 regulatory protein interface [polypeptide binding]; other site 1246995008812 active site 1246995008813 regulatory phosphorylation site [posttranslational modification]; other site 1246995008814 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1246995008815 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1246995008816 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1246995008817 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1246995008818 H+ Antiporter protein; Region: 2A0121; TIGR00900 1246995008819 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1246995008820 active site 1 [active] 1246995008821 active site 2 [active] 1246995008822 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1246995008823 Protein of unknown function (DUF2855); Region: DUF2855; pfam11017 1246995008824 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 1246995008825 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995008826 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1246995008827 DNA binding residues [nucleotide binding] 1246995008828 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 1246995008829 active site 1246995008830 catalytic residues [active] 1246995008831 H+ Antiporter protein; Region: 2A0121; TIGR00900 1246995008832 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1246995008833 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1246995008834 nudix motif; other site 1246995008835 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 1246995008836 active site 1246995008837 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1246995008838 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1246995008839 putative sugar binding sites [chemical binding]; other site 1246995008840 Q-X-W motif; other site 1246995008841 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1246995008842 Coenzyme A binding pocket [chemical binding]; other site 1246995008843 Right handed beta helix region; Region: Beta_helix; pfam13229 1246995008844 amino acid transporter; Region: 2A0306; TIGR00909 1246995008845 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1246995008846 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1246995008847 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 1246995008848 putative active site [active] 1246995008849 putative metal binding site [ion binding]; other site 1246995008850 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1246995008851 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995008852 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995008853 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1246995008854 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1246995008855 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1246995008856 putative phosphate binding site [ion binding]; other site 1246995008857 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1246995008858 putative catalytic site [active] 1246995008859 putative phosphate binding site [ion binding]; other site 1246995008860 putative metal binding site [ion binding]; other site 1246995008861 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 1246995008862 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 1246995008863 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1246995008864 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1246995008865 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1246995008866 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1246995008867 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1246995008868 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 1246995008869 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 1246995008870 DXD motif; other site 1246995008871 potential frameshift: common BLAST hit: gi|383777437|ref|YP_005462003.1| putative regulator of sigma factor 1246995008872 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1246995008873 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1246995008874 putative substrate translocation pore; other site 1246995008875 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1246995008876 active sites [active] 1246995008877 tetramer interface [polypeptide binding]; other site 1246995008878 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 1246995008879 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1246995008880 potential frameshift: common BLAST hit: gi|383780325|ref|YP_005464891.1| putative LacI-family transcriptional regulator 1246995008881 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1246995008882 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1246995008883 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1246995008884 putative active site [active] 1246995008885 classical (c) SDRs; Region: SDR_c; cd05233 1246995008886 NAD(P) binding site [chemical binding]; other site 1246995008887 active site 1246995008888 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 1246995008889 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1246995008890 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 1246995008891 active site 1246995008892 HIGH motif; other site 1246995008893 nucleotide binding site [chemical binding]; other site 1246995008894 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1246995008895 dimer interface [polypeptide binding]; other site 1246995008896 active site 1246995008897 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 1246995008898 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 1246995008899 putative ADP-binding pocket [chemical binding]; other site 1246995008900 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1246995008901 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1246995008902 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 1246995008903 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1246995008904 active site 1246995008905 motif I; other site 1246995008906 motif II; other site 1246995008907 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1246995008908 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1246995008909 putative active site [active] 1246995008910 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1246995008911 active site 1246995008912 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 1246995008913 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 1246995008914 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1246995008915 NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078 1246995008916 NAD(P) binding site [chemical binding]; other site 1246995008917 catalytic residues [active] 1246995008918 GAF domain; Region: GAF_2; pfam13185 1246995008919 ANTAR domain; Region: ANTAR; pfam03861 1246995008920 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1246995008921 GAF domain; Region: GAF; pfam01590 1246995008922 ANTAR domain; Region: ANTAR; pfam03861 1246995008923 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 1246995008924 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995008925 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1246995008926 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1246995008927 DNA binding residues [nucleotide binding] 1246995008928 adenylate kinase; Reviewed; Region: adk; PRK00279 1246995008929 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1246995008930 AMP-binding site [chemical binding]; other site 1246995008931 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1246995008932 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1246995008933 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1246995008934 Walker A/P-loop; other site 1246995008935 ATP binding site [chemical binding]; other site 1246995008936 Q-loop/lid; other site 1246995008937 ABC transporter signature motif; other site 1246995008938 Walker B; other site 1246995008939 D-loop; other site 1246995008940 H-loop/switch region; other site 1246995008941 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1246995008942 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1246995008943 siderophore binding site; other site 1246995008944 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1246995008945 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1246995008946 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1246995008947 ABC-ATPase subunit interface; other site 1246995008948 dimer interface [polypeptide binding]; other site 1246995008949 putative PBP binding regions; other site 1246995008950 citrate synthase 2; Provisional; Region: PRK12350 1246995008951 Citrate synthase; Region: Citrate_synt; pfam00285 1246995008952 oxalacetate binding site [chemical binding]; other site 1246995008953 citrylCoA binding site [chemical binding]; other site 1246995008954 coenzyme A binding site [chemical binding]; other site 1246995008955 catalytic triad [active] 1246995008956 Helix-turn-helix domain; Region: HTH_17; pfam12728 1246995008957 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 1246995008958 Citrate synthase; Region: Citrate_synt; pfam00285 1246995008959 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 1246995008960 coenzyme A binding site [chemical binding]; other site 1246995008961 citrylCoA binding site [chemical binding]; other site 1246995008962 oxalacetate binding site [chemical binding]; other site 1246995008963 catalytic triad [active] 1246995008964 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1246995008965 Cytochrome P450; Region: p450; cl12078 1246995008966 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1246995008967 cleavage site 1246995008968 active site 1246995008969 substrate binding sites [chemical binding]; other site 1246995008970 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1246995008971 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1246995008972 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1246995008973 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1246995008974 S-adenosylmethionine binding site [chemical binding]; other site 1246995008975 Predicted ATPase [General function prediction only]; Region: COG3911 1246995008976 AAA domain; Region: AAA_28; pfam13521 1246995008977 Protein of unknown function (DUF3500); Region: DUF3500; pfam12006 1246995008978 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1246995008979 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 1246995008980 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1246995008981 sugar binding site [chemical binding]; other site 1246995008982 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1246995008983 sugar binding site [chemical binding]; other site 1246995008984 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1246995008985 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1246995008986 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 1246995008987 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 1246995008988 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1246995008989 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1246995008990 FtsX-like permease family; Region: FtsX; pfam02687 1246995008991 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1246995008992 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1246995008993 Walker A/P-loop; other site 1246995008994 ATP binding site [chemical binding]; other site 1246995008995 Q-loop/lid; other site 1246995008996 ABC transporter signature motif; other site 1246995008997 Walker B; other site 1246995008998 D-loop; other site 1246995008999 H-loop/switch region; other site 1246995009000 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1246995009001 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 1246995009002 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995009003 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1246995009004 DNA binding residues [nucleotide binding] 1246995009005 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1246995009006 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1246995009007 active site 1246995009008 catalytic site [active] 1246995009009 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1246995009010 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1246995009011 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1246995009012 MarR family; Region: MarR_2; pfam12802 1246995009013 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 1246995009014 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1246995009015 classical (c) SDRs; Region: SDR_c; cd05233 1246995009016 NAD(P) binding site [chemical binding]; other site 1246995009017 active site 1246995009018 GAF domain; Region: GAF; pfam01590 1246995009019 GAF domain; Region: GAF_2; pfam13185 1246995009020 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1246995009021 Histidine kinase; Region: HisKA_3; pfam07730 1246995009022 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995009023 ATP binding site [chemical binding]; other site 1246995009024 Mg2+ binding site [ion binding]; other site 1246995009025 G-X-G motif; other site 1246995009026 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995009027 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995009028 active site 1246995009029 phosphorylation site [posttranslational modification] 1246995009030 intermolecular recognition site; other site 1246995009031 dimerization interface [polypeptide binding]; other site 1246995009032 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995009033 DNA binding residues [nucleotide binding] 1246995009034 dimerization interface [polypeptide binding]; other site 1246995009035 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1246995009036 MarR family; Region: MarR_2; pfam12802 1246995009037 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1246995009038 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1246995009039 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 1246995009040 DivIVA protein; Region: DivIVA; pfam05103 1246995009041 DivIVA domain; Region: DivI1A_domain; TIGR03544 1246995009042 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1246995009043 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1246995009044 DNA binding site [nucleotide binding] 1246995009045 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1246995009046 ligand binding site [chemical binding]; other site 1246995009047 dimerization interface [polypeptide binding]; other site 1246995009048 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 1246995009049 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1246995009050 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1246995009051 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1246995009052 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1246995009053 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1246995009054 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1246995009055 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1246995009056 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1246995009057 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1246995009058 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995009059 dimer interface [polypeptide binding]; other site 1246995009060 conserved gate region; other site 1246995009061 putative PBP binding loops; other site 1246995009062 ABC-ATPase subunit interface; other site 1246995009063 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1246995009064 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995009065 dimer interface [polypeptide binding]; other site 1246995009066 conserved gate region; other site 1246995009067 putative PBP binding loops; other site 1246995009068 ABC-ATPase subunit interface; other site 1246995009069 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1246995009070 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1246995009071 glucuronate isomerase; Reviewed; Region: PRK02925 1246995009072 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 1246995009073 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1246995009074 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1246995009075 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1246995009076 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1246995009077 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1246995009078 S-adenosylmethionine binding site [chemical binding]; other site 1246995009079 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1246995009080 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1246995009081 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1246995009082 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1246995009083 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 1246995009084 active site 1246995009085 catalytic triad [active] 1246995009086 oxyanion hole [active] 1246995009087 Uncharacterized conserved protein (DUF2203); Region: DUF2203; pfam09969 1246995009088 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1246995009089 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995009090 NAD(P) binding site [chemical binding]; other site 1246995009091 active site 1246995009092 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1246995009093 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1246995009094 NAD(P) binding site [chemical binding]; other site 1246995009095 catalytic residues [active] 1246995009096 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1246995009097 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1246995009098 putative DNA binding site [nucleotide binding]; other site 1246995009099 putative Zn2+ binding site [ion binding]; other site 1246995009100 AsnC family; Region: AsnC_trans_reg; pfam01037 1246995009101 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1246995009102 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1246995009103 tetramer interface [polypeptide binding]; other site 1246995009104 TPP-binding site [chemical binding]; other site 1246995009105 heterodimer interface [polypeptide binding]; other site 1246995009106 phosphorylation loop region [posttranslational modification] 1246995009107 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1246995009108 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1246995009109 alpha subunit interface [polypeptide binding]; other site 1246995009110 TPP binding site [chemical binding]; other site 1246995009111 heterodimer interface [polypeptide binding]; other site 1246995009112 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1246995009113 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1246995009114 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1246995009115 E3 interaction surface; other site 1246995009116 lipoyl attachment site [posttranslational modification]; other site 1246995009117 e3 binding domain; Region: E3_binding; pfam02817 1246995009118 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1246995009119 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1246995009120 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1246995009121 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1246995009122 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1246995009123 DNA binding site [nucleotide binding] 1246995009124 domain linker motif; other site 1246995009125 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1246995009126 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 1246995009127 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 1246995009128 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 1246995009129 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1246995009130 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1246995009131 active site 1246995009132 catalytic residues [active] 1246995009133 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1246995009134 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1246995009135 Cleaved Adhesin Domain; Region: Cleaved_Adhesin; pfam07675 1246995009136 Kelch domain; Region: Kelch; smart00612 1246995009137 Kelch domain; Region: Kelch; smart00612 1246995009138 Kelch motif; Region: Kelch_1; pfam01344 1246995009139 Kelch domain; Region: Kelch; smart00612 1246995009140 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1246995009141 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1246995009142 DNA binding site [nucleotide binding] 1246995009143 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1246995009144 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1246995009145 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1246995009146 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1246995009147 active site 1246995009148 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1246995009149 metal binding site [ion binding]; metal-binding site 1246995009150 active site 1246995009151 I-site; other site 1246995009152 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1246995009153 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 1246995009154 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1246995009155 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1246995009156 catalytic residue [active] 1246995009157 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1246995009158 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1246995009159 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1246995009160 active site 1246995009161 ATP binding site [chemical binding]; other site 1246995009162 substrate binding site [chemical binding]; other site 1246995009163 activation loop (A-loop); other site 1246995009164 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094 1246995009165 Recombinase; Region: Recombinase; pfam07508 1246995009166 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1246995009167 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995009168 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1246995009169 DNA binding residues [nucleotide binding] 1246995009170 putative lipid kinase; Reviewed; Region: PRK13057 1246995009171 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1246995009172 TetR family transcriptional regulator; Provisional; Region: PRK14996 1246995009173 hypothetical protein; Provisional; Region: PRK07236 1246995009174 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1246995009175 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1246995009176 putative sugar binding sites [chemical binding]; other site 1246995009177 Q-X-W motif; other site 1246995009178 Ricin-type beta-trefoil lectin domain-like; Region: RicinB_lectin_2; pfam14200 1246995009179 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1246995009180 putative hydrophobic ligand binding site [chemical binding]; other site 1246995009181 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1246995009182 dimerization interface [polypeptide binding]; other site 1246995009183 putative DNA binding site [nucleotide binding]; other site 1246995009184 putative Zn2+ binding site [ion binding]; other site 1246995009185 RibD C-terminal domain; Region: RibD_C; cl17279 1246995009186 tyrosine decarboxylase; Region: PLN02880 1246995009187 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 1246995009188 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1246995009189 catalytic residue [active] 1246995009190 PAS domain S-box; Region: sensory_box; TIGR00229 1246995009191 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1246995009192 putative active site [active] 1246995009193 heme pocket [chemical binding]; other site 1246995009194 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1246995009195 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1246995009196 metal binding site [ion binding]; metal-binding site 1246995009197 active site 1246995009198 I-site; other site 1246995009199 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1246995009200 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 1246995009201 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1246995009202 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1246995009203 catalytic residue [active] 1246995009204 H+ Antiporter protein; Region: 2A0121; TIGR00900 1246995009205 SnoaL-like domain; Region: SnoaL_3; pfam13474 1246995009206 alpha-galactosidase; Region: PLN02808; cl17638 1246995009207 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1246995009208 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1246995009209 putative sugar binding sites [chemical binding]; other site 1246995009210 Q-X-W motif; other site 1246995009211 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1246995009212 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1246995009213 short chain dehydrogenase; Provisional; Region: PRK05854 1246995009214 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1246995009215 putative NAD(P) binding site [chemical binding]; other site 1246995009216 active site 1246995009217 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1246995009218 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1246995009219 RibD C-terminal domain; Region: RibD_C; cl17279 1246995009220 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1246995009221 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1246995009222 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1246995009223 nucleotide binding site [chemical binding]; other site 1246995009224 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 1246995009225 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1246995009226 ligand binding site [chemical binding]; other site 1246995009227 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1246995009228 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1246995009229 TM-ABC transporter signature motif; other site 1246995009230 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1246995009231 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1246995009232 Walker A/P-loop; other site 1246995009233 ATP binding site [chemical binding]; other site 1246995009234 Q-loop/lid; other site 1246995009235 ABC transporter signature motif; other site 1246995009236 Walker B; other site 1246995009237 D-loop; other site 1246995009238 H-loop/switch region; other site 1246995009239 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 1246995009240 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1246995009241 active site 1246995009242 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995009243 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1246995009244 NAD(P) binding site [chemical binding]; other site 1246995009245 active site 1246995009246 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1246995009247 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1246995009248 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1246995009249 metal binding site [ion binding]; metal-binding site 1246995009250 active site 1246995009251 I-site; other site 1246995009252 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1246995009253 CHASE domain; Region: CHASE; pfam03924 1246995009254 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1246995009255 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1246995009256 dimer interface [polypeptide binding]; other site 1246995009257 phosphorylation site [posttranslational modification] 1246995009258 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995009259 ATP binding site [chemical binding]; other site 1246995009260 Mg2+ binding site [ion binding]; other site 1246995009261 G-X-G motif; other site 1246995009262 RDD family; Region: RDD; pfam06271 1246995009263 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 1246995009264 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1246995009265 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1246995009266 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1246995009267 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1246995009268 non-specific DNA binding site [nucleotide binding]; other site 1246995009269 salt bridge; other site 1246995009270 sequence-specific DNA binding site [nucleotide binding]; other site 1246995009271 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 1246995009272 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1246995009273 Predicted flavoprotein [General function prediction only]; Region: COG0431 1246995009274 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995009275 Response regulator receiver domain; Region: Response_reg; pfam00072 1246995009276 active site 1246995009277 phosphorylation site [posttranslational modification] 1246995009278 intermolecular recognition site; other site 1246995009279 dimerization interface [polypeptide binding]; other site 1246995009280 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1246995009281 GAF domain; Region: GAF; pfam01590 1246995009282 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1246995009283 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 1246995009284 active site 1246995009285 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 1246995009286 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1246995009287 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995009288 ATP binding site [chemical binding]; other site 1246995009289 Mg2+ binding site [ion binding]; other site 1246995009290 G-X-G motif; other site 1246995009291 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1246995009292 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 1246995009293 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1246995009294 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1246995009295 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 1246995009296 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1246995009297 DNA binding site [nucleotide binding] 1246995009298 AAA ATPase domain; Region: AAA_16; pfam13191 1246995009299 Predicted ATPase [General function prediction only]; Region: COG3903 1246995009300 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1246995009301 anti sigma factor interaction site; other site 1246995009302 regulatory phosphorylation site [posttranslational modification]; other site 1246995009303 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1246995009304 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1246995009305 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1246995009306 FtsX-like permease family; Region: FtsX; pfam02687 1246995009307 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1246995009308 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1246995009309 Walker A/P-loop; other site 1246995009310 ATP binding site [chemical binding]; other site 1246995009311 Q-loop/lid; other site 1246995009312 ABC transporter signature motif; other site 1246995009313 Walker B; other site 1246995009314 D-loop; other site 1246995009315 H-loop/switch region; other site 1246995009316 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1246995009317 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1246995009318 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1246995009319 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995009320 active site 1246995009321 phosphorylation site [posttranslational modification] 1246995009322 intermolecular recognition site; other site 1246995009323 dimerization interface [polypeptide binding]; other site 1246995009324 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1246995009325 DNA binding site [nucleotide binding] 1246995009326 HAMP domain; Region: HAMP; pfam00672 1246995009327 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1246995009328 phosphorylation site [posttranslational modification] 1246995009329 dimer interface [polypeptide binding]; other site 1246995009330 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995009331 ATP binding site [chemical binding]; other site 1246995009332 Mg2+ binding site [ion binding]; other site 1246995009333 G-X-G motif; other site 1246995009334 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1246995009335 metal binding site [ion binding]; metal-binding site 1246995009336 active site 1246995009337 I-site; other site 1246995009338 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1246995009339 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1246995009340 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 1246995009341 putative ADP-binding pocket [chemical binding]; other site 1246995009342 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 1246995009343 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1246995009344 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1246995009345 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1246995009346 Putative oxidoreductase C terminal; Region: ox_reductase_C; pfam08635 1246995009347 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 1246995009348 putative NAD(P) binding site [chemical binding]; other site 1246995009349 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1246995009350 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1246995009351 metal binding site [ion binding]; metal-binding site 1246995009352 active site 1246995009353 I-site; other site 1246995009354 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1246995009355 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1246995009356 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1246995009357 metal binding site [ion binding]; metal-binding site 1246995009358 active site 1246995009359 I-site; other site 1246995009360 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1246995009361 Domain of unknown function (DUF427); Region: DUF427; pfam04248 1246995009362 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1246995009363 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995009364 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 1246995009365 active site 1246995009366 catalytic residues [active] 1246995009367 CHAT domain; Region: CHAT; pfam12770 1246995009368 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1246995009369 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1246995009370 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1246995009371 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1246995009372 Coenzyme A binding pocket [chemical binding]; other site 1246995009373 von Hippel-Landau (pVHL) tumor suppressor protein; Region: pVHL; cl03381 1246995009374 pVHL-HIF-1alpha interaction [polypeptide binding]; other site 1246995009375 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 1246995009376 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1246995009377 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 1246995009378 conserved cys residue [active] 1246995009379 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1246995009380 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1246995009381 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1246995009382 conserved cys residue [active] 1246995009383 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1246995009384 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1246995009385 anti sigma factor interaction site; other site 1246995009386 regulatory phosphorylation site [posttranslational modification]; other site 1246995009387 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1246995009388 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1246995009389 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1246995009390 catalytic residue [active] 1246995009391 Cupin; Region: Cupin_6; pfam12852 1246995009392 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1246995009393 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1246995009394 oxidoreductase; Provisional; Region: PRK06196 1246995009395 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1246995009396 putative NAD(P) binding site [chemical binding]; other site 1246995009397 active site 1246995009398 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 1246995009399 Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028 1246995009400 active site 1246995009401 DNA binding site [nucleotide binding] 1246995009402 Int/Topo IB signature motif; other site 1246995009403 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1246995009404 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1246995009405 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 1246995009406 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995009407 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1246995009408 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1246995009409 DNA binding residues [nucleotide binding] 1246995009410 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1246995009411 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1246995009412 DNA binding site [nucleotide binding] 1246995009413 domain linker motif; other site 1246995009414 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 1246995009415 putative dimerization interface [polypeptide binding]; other site 1246995009416 putative ligand binding site [chemical binding]; other site 1246995009417 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1246995009418 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1246995009419 active site 1246995009420 ATP binding site [chemical binding]; other site 1246995009421 substrate binding site [chemical binding]; other site 1246995009422 activation loop (A-loop); other site 1246995009423 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1246995009424 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1246995009425 putative sugar binding sites [chemical binding]; other site 1246995009426 Q-X-W motif; other site 1246995009427 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 1246995009428 active site 1246995009429 catalytic triad [active] 1246995009430 oxyanion hole [active] 1246995009431 TAP-like protein; Region: Abhydrolase_4; pfam08386 1246995009432 Family description; Region: VCBS; pfam13517 1246995009433 Family description; Region: VCBS; pfam13517 1246995009434 Family description; Region: VCBS; pfam13517 1246995009435 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1246995009436 sequence-specific DNA binding site [nucleotide binding]; other site 1246995009437 salt bridge; other site 1246995009438 Cupin domain; Region: Cupin_2; pfam07883 1246995009439 putative pectinesterase; Region: PLN02432; cl01911 1246995009440 Pectinesterase; Region: Pectinesterase; pfam01095 1246995009441 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 1246995009442 active site 1246995009443 catalytic residues [active] 1246995009444 metal binding site [ion binding]; metal-binding site 1246995009445 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1246995009446 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1246995009447 DNA-binding site [nucleotide binding]; DNA binding site 1246995009448 FCD domain; Region: FCD; pfam07729 1246995009449 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1246995009450 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1246995009451 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 1246995009452 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 1246995009453 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 1246995009454 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 1246995009455 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 1246995009456 Isochorismatase family; Region: Isochorismatase; pfam00857 1246995009457 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1246995009458 catalytic triad [active] 1246995009459 conserved cis-peptide bond; other site 1246995009460 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1246995009461 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1246995009462 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1246995009463 Glycosyltransferase family 36; Region: Glyco_transf_36; pfam06165 1246995009464 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1246995009465 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 1246995009466 metal binding site [ion binding]; metal-binding site 1246995009467 ligand binding site [chemical binding]; other site 1246995009468 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1246995009469 MarR family; Region: MarR_2; pfam12802 1246995009470 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1246995009471 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1246995009472 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1246995009473 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1246995009474 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995009475 dimer interface [polypeptide binding]; other site 1246995009476 conserved gate region; other site 1246995009477 ABC-ATPase subunit interface; other site 1246995009478 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1246995009479 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995009480 ABC-ATPase subunit interface; other site 1246995009481 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1246995009482 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 1246995009483 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 1246995009484 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1246995009485 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 1246995009486 GAF domain; Region: GAF; cl17456 1246995009487 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1246995009488 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 1246995009489 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 1246995009490 Cellulose binding domain; Region: CBM_2; pfam00553 1246995009491 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995009492 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995009493 active site 1246995009494 phosphorylation site [posttranslational modification] 1246995009495 intermolecular recognition site; other site 1246995009496 dimerization interface [polypeptide binding]; other site 1246995009497 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995009498 DNA binding residues [nucleotide binding] 1246995009499 dimerization interface [polypeptide binding]; other site 1246995009500 Histidine kinase; Region: HisKA_3; pfam07730 1246995009501 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1246995009502 Lacto-N-biose phosphorylase; Region: Lact_bio_phlase; pfam09508 1246995009503 Caspase domain; Region: Peptidase_C14; pfam00656 1246995009504 5'-3' exonuclease; Region: 53EXOc; smart00475 1246995009505 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1246995009506 active site 1246995009507 metal binding site 1 [ion binding]; metal-binding site 1246995009508 putative 5' ssDNA interaction site; other site 1246995009509 metal binding site 3; metal-binding site 1246995009510 metal binding site 2 [ion binding]; metal-binding site 1246995009511 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1246995009512 putative DNA binding site [nucleotide binding]; other site 1246995009513 putative metal binding site [ion binding]; other site 1246995009514 Predicted transcriptional regulator [Transcription]; Region: COG2378 1246995009515 HTH domain; Region: HTH_11; pfam08279 1246995009516 WYL domain; Region: WYL; pfam13280 1246995009517 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1246995009518 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1246995009519 active site 1246995009520 aminotransferase; Validated; Region: PRK07046 1246995009521 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1246995009522 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1246995009523 catalytic residue [active] 1246995009524 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 1246995009525 putative active site pocket [active] 1246995009526 cleavage site 1246995009527 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1246995009528 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995009529 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1246995009530 DNA binding residues [nucleotide binding] 1246995009531 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 1246995009532 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1246995009533 Catalytic NodB homology domain of Streptomyces lividans acetylxylan esterase and its bacterial homologs; Region: CE4_SlAXE_like; cd10953 1246995009534 NodB motif; other site 1246995009535 active site 1246995009536 catalytic site [active] 1246995009537 Zn binding site [ion binding]; other site 1246995009538 dimer interface [polypeptide binding]; other site 1246995009539 CBD_II domain; Region: CBD_II; smart00637 1246995009540 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1246995009541 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1246995009542 active site 1246995009543 PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398 1246995009544 active site 1246995009545 MOSC domain; Region: MOSC; pfam03473 1246995009546 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1246995009547 active site 1246995009548 phosphorylation site [posttranslational modification] 1246995009549 intermolecular recognition site; other site 1246995009550 dimerization interface [polypeptide binding]; other site 1246995009551 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 1246995009552 dimer interface [polypeptide binding]; other site 1246995009553 catalytic triad [active] 1246995009554 Lamin Tail Domain; Region: LTD; pfam00932 1246995009555 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1246995009556 active site 1246995009557 metal binding site [ion binding]; metal-binding site 1246995009558 TIGR03086 family protein; Region: TIGR03086 1246995009559 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1246995009560 anti sigma factor interaction site; other site 1246995009561 regulatory phosphorylation site [posttranslational modification]; other site 1246995009562 RibD C-terminal domain; Region: RibD_C; cl17279 1246995009563 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 1246995009564 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1246995009565 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1246995009566 Helix-turn-helix domain; Region: HTH_31; pfam13560 1246995009567 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1246995009568 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1246995009569 substrate binding pocket [chemical binding]; other site 1246995009570 membrane-bound complex binding site; other site 1246995009571 hinge residues; other site 1246995009572 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1246995009573 metal binding site [ion binding]; metal-binding site 1246995009574 active site 1246995009575 I-site; other site 1246995009576 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1246995009577 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1246995009578 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1246995009579 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1246995009580 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1246995009581 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1246995009582 Small secreted domain (DUF320); Region: DUF320; pfam03777 1246995009583 Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270 1246995009584 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 1246995009585 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1246995009586 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1246995009587 metal ion-dependent adhesion site (MIDAS); other site 1246995009588 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1246995009589 active site 1246995009590 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1246995009591 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1246995009592 S-adenosylmethionine binding site [chemical binding]; other site 1246995009593 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1246995009594 EamA-like transporter family; Region: EamA; pfam00892 1246995009595 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1246995009596 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1246995009597 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 1246995009598 putative dimerization interface [polypeptide binding]; other site 1246995009599 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 1246995009600 active site 1246995009601 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1246995009602 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1246995009603 putative sugar binding sites [chemical binding]; other site 1246995009604 Q-X-W motif; other site 1246995009605 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 1246995009606 substrate binding site [chemical binding]; other site 1246995009607 active site 1246995009608 Amb_all domain; Region: Amb_all; smart00656 1246995009609 Right handed beta helix region; Region: Beta_helix; pfam13229 1246995009610 Chitin binding domain; Region: Chitin_bind_3; pfam03067 1246995009611 Cellulose binding domain; Region: CBM_2; pfam00553 1246995009612 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 1246995009613 Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; cl17492 1246995009614 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1246995009615 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1246995009616 putative acyl-acceptor binding pocket; other site 1246995009617 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1246995009618 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1246995009619 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1246995009620 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 1246995009621 DNA-binding site [nucleotide binding]; DNA binding site 1246995009622 FCD domain; Region: FCD; pfam07729 1246995009623 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1246995009624 FAD binding domain; Region: FAD_binding_4; pfam01565 1246995009625 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1246995009626 Cysteine-rich domain; Region: CCG; pfam02754 1246995009627 Predicted transcriptional regulators [Transcription]; Region: COG1733 1246995009628 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1246995009629 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1246995009630 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1246995009631 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995009632 NAD(P) binding site [chemical binding]; other site 1246995009633 active site 1246995009634 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1246995009635 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 1246995009636 Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324 1246995009637 NADP binding site [chemical binding]; other site 1246995009638 substrate binding site [chemical binding]; other site 1246995009639 active site 1246995009640 Helix-turn-helix domain; Region: HTH_31; pfam13560 1246995009641 salt bridge; other site 1246995009642 non-specific DNA binding site [nucleotide binding]; other site 1246995009643 sequence-specific DNA binding site [nucleotide binding]; other site 1246995009644 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1246995009645 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 1246995009646 putative ADP-binding pocket [chemical binding]; other site 1246995009647 Protein of unknown function (DUF3184); Region: DUF3184; pfam11380 1246995009648 Protein of unknown function (DUF3184); Region: DUF3184; pfam11380 1246995009649 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 1246995009650 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1246995009651 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1246995009652 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1246995009653 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1246995009654 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1246995009655 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1246995009656 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995009657 dimer interface [polypeptide binding]; other site 1246995009658 conserved gate region; other site 1246995009659 putative PBP binding loops; other site 1246995009660 ABC-ATPase subunit interface; other site 1246995009661 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1246995009662 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995009663 dimer interface [polypeptide binding]; other site 1246995009664 conserved gate region; other site 1246995009665 putative PBP binding loops; other site 1246995009666 ABC-ATPase subunit interface; other site 1246995009667 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1246995009668 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1246995009669 DNA binding site [nucleotide binding] 1246995009670 Ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation; Region: PBP1_CatR_like; cd06296 1246995009671 putative dimerization interface [polypeptide binding]; other site 1246995009672 putative ligand binding site [chemical binding]; other site 1246995009673 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 1246995009674 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830 1246995009675 active site 1246995009676 catalytic triad [active] 1246995009677 oxyanion hole [active] 1246995009678 Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648 1246995009679 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830 1246995009680 active site 1246995009681 catalytic triad [active] 1246995009682 oxyanion hole [active] 1246995009683 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1246995009684 conserved cys residue [active] 1246995009685 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 1246995009686 CBD_II domain; Region: CBD_II; smart00637 1246995009687 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 1246995009688 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1246995009689 Cellulose binding domain; Region: CBM_2; pfam00553 1246995009690 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1246995009691 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1246995009692 metal ion-dependent adhesion site (MIDAS); other site 1246995009693 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 1246995009694 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1246995009695 nucleotide binding pocket [chemical binding]; other site 1246995009696 K-X-D-G motif; other site 1246995009697 catalytic site [active] 1246995009698 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1246995009699 RibD C-terminal domain; Region: RibD_C; cl17279 1246995009700 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1246995009701 PBP superfamily domain; Region: PBP_like_2; cl17296 1246995009702 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1246995009703 active site 1246995009704 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1246995009705 catalytic tetrad [active] 1246995009706 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995009707 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995009708 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1246995009709 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1246995009710 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995009711 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1246995009712 Walker A/P-loop; other site 1246995009713 ATP binding site [chemical binding]; other site 1246995009714 Q-loop/lid; other site 1246995009715 ABC transporter signature motif; other site 1246995009716 Walker B; other site 1246995009717 D-loop; other site 1246995009718 H-loop/switch region; other site 1246995009719 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995009720 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995009721 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1246995009722 PS-10 peptidase S37; Region: Peptidase_S37; pfam05576 1246995009723 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1246995009724 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1246995009725 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1246995009726 active site 1246995009727 catalytic tetrad [active] 1246995009728 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1246995009729 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1246995009730 active site 1246995009731 ATP binding site [chemical binding]; other site 1246995009732 substrate binding site [chemical binding]; other site 1246995009733 activation loop (A-loop); other site 1246995009734 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1246995009735 classical (c) SDRs; Region: SDR_c; cd05233 1246995009736 NAD(P) binding site [chemical binding]; other site 1246995009737 active site 1246995009738 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995009739 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995009740 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 1246995009741 peptidase domain interface [polypeptide binding]; other site 1246995009742 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 1246995009743 active site 1246995009744 catalytic triad [active] 1246995009745 calcium binding site [ion binding]; other site 1246995009746 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1246995009747 metal binding site [ion binding]; metal-binding site 1246995009748 active site 1246995009749 I-site; other site 1246995009750 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1246995009751 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1246995009752 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1246995009753 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1246995009754 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1246995009755 active site 1246995009756 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1246995009757 Glyoxal oxidase N-terminus; Region: Glyoxal_oxid_N; pfam07250 1246995009758 C-terminal Early set domain associated with the catalytic domain of galactose oxidase; Region: E_set_GO_C; cd02851 1246995009759 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 1246995009760 von Willebrand factor type D domain; Region: VWD; cl02516 1246995009761 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 1246995009762 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1246995009763 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 1246995009764 Beta-lactamase; Region: Beta-lactamase; pfam00144 1246995009765 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1246995009766 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 1246995009767 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 1246995009768 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1246995009769 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1246995009770 dimer interface [polypeptide binding]; other site 1246995009771 putative CheW interface [polypeptide binding]; other site 1246995009772 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1246995009773 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995009774 Walker A/P-loop; other site 1246995009775 ATP binding site [chemical binding]; other site 1246995009776 Q-loop/lid; other site 1246995009777 ABC transporter signature motif; other site 1246995009778 Walker B; other site 1246995009779 D-loop; other site 1246995009780 H-loop/switch region; other site 1246995009781 TOBE domain; Region: TOBE_2; pfam08402 1246995009782 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1246995009783 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995009784 dimer interface [polypeptide binding]; other site 1246995009785 conserved gate region; other site 1246995009786 putative PBP binding loops; other site 1246995009787 ABC-ATPase subunit interface; other site 1246995009788 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995009789 dimer interface [polypeptide binding]; other site 1246995009790 conserved gate region; other site 1246995009791 putative PBP binding loops; other site 1246995009792 ABC-ATPase subunit interface; other site 1246995009793 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1246995009794 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1246995009795 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1246995009796 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 1246995009797 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1246995009798 Zn binding site [ion binding]; other site 1246995009799 Uncharacterized conserved protein [Function unknown]; Region: COG3268 1246995009800 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995009801 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1246995009802 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1246995009803 metal binding site [ion binding]; metal-binding site 1246995009804 active site 1246995009805 I-site; other site 1246995009806 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995009807 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1246995009808 NAD(P) binding site [chemical binding]; other site 1246995009809 active site 1246995009810 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1246995009811 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 1246995009812 Protein phosphatase 2C; Region: PP2C; pfam00481 1246995009813 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1246995009814 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1246995009815 DNA binding site [nucleotide binding] 1246995009816 domain linker motif; other site 1246995009817 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1246995009818 ligand binding site [chemical binding]; other site 1246995009819 dimerization interface [polypeptide binding]; other site 1246995009820 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1246995009821 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1246995009822 Protein of unknown function (DUF993); Region: DUF993; pfam06187 1246995009823 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1246995009824 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1246995009825 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1246995009826 DNA binding site [nucleotide binding] 1246995009827 domain linker motif; other site 1246995009828 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1246995009829 dimerization interface [polypeptide binding]; other site 1246995009830 ligand binding site [chemical binding]; other site 1246995009831 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1246995009832 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_5; cd06338 1246995009833 putative ligand binding site [chemical binding]; other site 1246995009834 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1246995009835 TM-ABC transporter signature motif; other site 1246995009836 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1246995009837 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1246995009838 TM-ABC transporter signature motif; other site 1246995009839 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1246995009840 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1246995009841 Walker A/P-loop; other site 1246995009842 ATP binding site [chemical binding]; other site 1246995009843 Q-loop/lid; other site 1246995009844 ABC transporter signature motif; other site 1246995009845 Walker B; other site 1246995009846 D-loop; other site 1246995009847 H-loop/switch region; other site 1246995009848 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1246995009849 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1246995009850 Walker A/P-loop; other site 1246995009851 ATP binding site [chemical binding]; other site 1246995009852 Q-loop/lid; other site 1246995009853 ABC transporter signature motif; other site 1246995009854 Walker B; other site 1246995009855 D-loop; other site 1246995009856 H-loop/switch region; other site 1246995009857 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1246995009858 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1246995009859 Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563 1246995009860 active site triad [active] 1246995009861 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1246995009862 substrate binding site [chemical binding]; other site 1246995009863 activation loop (A-loop); other site 1246995009864 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1246995009865 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1246995009866 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1246995009867 catalytic residue [active] 1246995009868 cystathionine gamma-synthase; Provisional; Region: PRK08574 1246995009869 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1246995009870 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1246995009871 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995009872 Q-loop/lid; other site 1246995009873 ABC transporter signature motif; other site 1246995009874 Walker B; other site 1246995009875 D-loop; other site 1246995009876 H-loop/switch region; other site 1246995009877 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1246995009878 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1246995009879 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995009880 Walker A/P-loop; other site 1246995009881 ATP binding site [chemical binding]; other site 1246995009882 Q-loop/lid; other site 1246995009883 ABC transporter signature motif; other site 1246995009884 Walker B; other site 1246995009885 D-loop; other site 1246995009886 H-loop/switch region; other site 1246995009887 Arginase family; Region: Arginase; pfam00491 1246995009888 active site 1246995009889 metal binding site [ion binding]; metal-binding site 1246995009890 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 1246995009891 SpaB C-terminal domain; Region: SpaB_C; pfam14028 1246995009892 DNA binding site [nucleotide binding] 1246995009893 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1246995009894 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1246995009895 Melibiase; Region: Melibiase; pfam02065 1246995009896 Domain of unknown function (DUF309); Region: DUF309; pfam03745 1246995009897 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1246995009898 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1246995009899 [2Fe-2S] cluster binding site [ion binding]; other site 1246995009900 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 1246995009901 putative alpha subunit interface [polypeptide binding]; other site 1246995009902 putative active site [active] 1246995009903 putative substrate binding site [chemical binding]; other site 1246995009904 Fe binding site [ion binding]; other site 1246995009905 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 1246995009906 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 1246995009907 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1246995009908 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1246995009909 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 1246995009910 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 1246995009911 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1246995009912 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1246995009913 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1246995009914 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995009915 dimer interface [polypeptide binding]; other site 1246995009916 conserved gate region; other site 1246995009917 putative PBP binding loops; other site 1246995009918 ABC-ATPase subunit interface; other site 1246995009919 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995009920 dimer interface [polypeptide binding]; other site 1246995009921 conserved gate region; other site 1246995009922 ABC-ATPase subunit interface; other site 1246995009923 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 1246995009924 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1246995009925 Walker A/P-loop; other site 1246995009926 ATP binding site [chemical binding]; other site 1246995009927 Q-loop/lid; other site 1246995009928 ABC transporter signature motif; other site 1246995009929 Walker B; other site 1246995009930 D-loop; other site 1246995009931 H-loop/switch region; other site 1246995009932 choline dehydrogenase; Validated; Region: PRK02106 1246995009933 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1246995009934 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1246995009935 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1246995009936 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 1246995009937 dimerization interface [polypeptide binding]; other site 1246995009938 DNA binding residues [nucleotide binding] 1246995009939 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995009940 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1246995009941 Walker A/P-loop; other site 1246995009942 ATP binding site [chemical binding]; other site 1246995009943 Q-loop/lid; other site 1246995009944 ABC transporter signature motif; other site 1246995009945 Walker B; other site 1246995009946 D-loop; other site 1246995009947 H-loop/switch region; other site 1246995009948 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1246995009949 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1246995009950 catalytic residue [active] 1246995009951 dimer interface [polypeptide binding]; other site 1246995009952 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1246995009953 active sites [active] 1246995009954 tetramer interface [polypeptide binding]; other site 1246995009955 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1246995009956 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1246995009957 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1246995009958 acyl-activating enzyme (AAE) consensus motif; other site 1246995009959 AMP binding site [chemical binding]; other site 1246995009960 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1246995009961 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 1246995009962 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1246995009963 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 1246995009964 active site 1246995009965 iron coordination sites [ion binding]; other site 1246995009966 substrate binding pocket [chemical binding]; other site 1246995009967 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1246995009968 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1246995009969 Coenzyme B12-dependent glutamate mutase epsilon subunit-like family; contains proteins similar to Clostridium cochlearium glutamate mutase (Glm) and Streptomyces tendae Tu901 NikV. Glm catalyzes a carbon-skeleton rearrangement of L-glutamate to...; Region: Glm_e; cd00245 1246995009970 substrate binding site [chemical binding]; other site 1246995009971 B12 cofactor binding site [chemical binding]; other site 1246995009972 heterodimer (sigma-epsilon) interface [polypeptide binding]; other site 1246995009973 homodimer (epsilon-epsilon) interface [polypeptide binding]; other site 1246995009974 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1246995009975 B12 binding site [chemical binding]; other site 1246995009976 acyl-CoA synthetase; Validated; Region: PRK05850 1246995009977 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1246995009978 acyl-activating enzyme (AAE) consensus motif; other site 1246995009979 active site 1246995009980 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1246995009981 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1246995009982 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1246995009983 active site 1246995009984 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1246995009985 Condensation domain; Region: Condensation; pfam00668 1246995009986 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1246995009987 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1246995009988 acyl-activating enzyme (AAE) consensus motif; other site 1246995009989 AMP binding site [chemical binding]; other site 1246995009990 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1246995009991 Condensation domain; Region: Condensation; pfam00668 1246995009992 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1246995009993 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1246995009994 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1246995009995 Condensation domain; Region: Condensation; pfam00668 1246995009996 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1246995009997 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1246995009998 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1246995009999 acyl-activating enzyme (AAE) consensus motif; other site 1246995010000 AMP binding site [chemical binding]; other site 1246995010001 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1246995010002 Condensation domain; Region: Condensation; pfam00668 1246995010003 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1246995010004 Condensation domain; Region: Condensation; pfam00668 1246995010005 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1246995010006 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1246995010007 acyl-activating enzyme (AAE) consensus motif; other site 1246995010008 AMP binding site [chemical binding]; other site 1246995010009 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1246995010010 Condensation domain; Region: Condensation; pfam00668 1246995010011 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1246995010012 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1246995010013 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1246995010014 acyl-activating enzyme (AAE) consensus motif; other site 1246995010015 AMP binding site [chemical binding]; other site 1246995010016 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1246995010017 Condensation domain; Region: Condensation; pfam00668 1246995010018 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1246995010019 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1246995010020 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 1246995010021 acyl-activating enzyme (AAE) consensus motif; other site 1246995010022 AMP binding site [chemical binding]; other site 1246995010023 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1246995010024 Condensation domain; Region: Condensation; pfam00668 1246995010025 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1246995010026 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1246995010027 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1246995010028 acyl-activating enzyme (AAE) consensus motif; other site 1246995010029 AMP binding site [chemical binding]; other site 1246995010030 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1246995010031 Condensation domain; Region: Condensation; pfam00668 1246995010032 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1246995010033 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1246995010034 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 1246995010035 acyl-activating enzyme (AAE) consensus motif; other site 1246995010036 AMP binding site [chemical binding]; other site 1246995010037 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1246995010038 Condensation domain; Region: Condensation; pfam00668 1246995010039 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1246995010040 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1246995010041 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1246995010042 acyl-activating enzyme (AAE) consensus motif; other site 1246995010043 AMP binding site [chemical binding]; other site 1246995010044 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1246995010045 Condensation domain; Region: Condensation; pfam00668 1246995010046 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1246995010047 Condensation domain; Region: Condensation; pfam00668 1246995010048 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1246995010049 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1246995010050 acyl-activating enzyme (AAE) consensus motif; other site 1246995010051 AMP binding site [chemical binding]; other site 1246995010052 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1246995010053 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1246995010054 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1246995010055 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1246995010056 acyl-activating enzyme (AAE) consensus motif; other site 1246995010057 AMP binding site [chemical binding]; other site 1246995010058 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1246995010059 MbtH-like protein; Region: MbtH; pfam03621 1246995010060 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1246995010061 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1246995010062 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1246995010063 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1246995010064 MMPL family; Region: MMPL; pfam03176 1246995010065 Ornithine cyclodeaminase/mu-crystallin family; Region: OCD_Mu_crystall; pfam02423 1246995010066 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1246995010067 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995010068 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995010069 active site 1246995010070 phosphorylation site [posttranslational modification] 1246995010071 intermolecular recognition site; other site 1246995010072 dimerization interface [polypeptide binding]; other site 1246995010073 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995010074 DNA binding residues [nucleotide binding] 1246995010075 dimerization interface [polypeptide binding]; other site 1246995010076 Histidine kinase; Region: HisKA_3; pfam07730 1246995010077 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1246995010078 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 1246995010079 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 1246995010080 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1246995010081 putative substrate translocation pore; other site 1246995010082 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1246995010083 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995010084 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 1246995010085 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1246995010086 tetramer interface [polypeptide binding]; other site 1246995010087 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1246995010088 catalytic residue [active] 1246995010089 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1246995010090 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1246995010091 SnoaL-like domain; Region: SnoaL_4; pfam13577 1246995010092 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1246995010093 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1246995010094 metal binding site [ion binding]; metal-binding site 1246995010095 active site 1246995010096 I-site; other site 1246995010097 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 1246995010098 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1246995010099 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1246995010100 putative dimer interface [polypeptide binding]; other site 1246995010101 threonine synthase; Validated; Region: PRK06260 1246995010102 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1246995010103 homodimer interface [polypeptide binding]; other site 1246995010104 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1246995010105 catalytic residue [active] 1246995010106 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 1246995010107 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1246995010108 putative active site [active] 1246995010109 metal binding site [ion binding]; metal-binding site 1246995010110 DoxX-like family; Region: DoxX_2; pfam13564 1246995010111 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 1246995010112 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1246995010113 active site 1246995010114 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 1246995010115 DNA binding site [nucleotide binding] 1246995010116 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1246995010117 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1246995010118 putative active site [active] 1246995010119 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 1246995010120 putative active site [active] 1246995010121 potential frameshift: common BLAST hit: gi|258652454|ref|YP_003201610.1| molybdopterin oxidoreductase 1246995010122 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 1246995010123 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1246995010124 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1246995010125 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1246995010126 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases [Inorganic ion transport and metabolism / General function prediction only]; Region: {NirD}; COG2146 1246995010127 iron-sulfur cluster [ion binding]; other site 1246995010128 [2Fe-2S] cluster binding site [ion binding]; other site 1246995010129 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 1246995010130 dimerization interface [polypeptide binding]; other site 1246995010131 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase); Region: GlcNAc_2-epim; pfam07221 1246995010132 putative active cleft [active] 1246995010133 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1246995010134 cleavage site 1246995010135 active site 1246995010136 substrate binding sites [chemical binding]; other site 1246995010137 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1246995010138 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995010139 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1246995010140 NAD(P) binding site [chemical binding]; other site 1246995010141 active site 1246995010142 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1246995010143 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1246995010144 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1246995010145 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1246995010146 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1246995010147 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995010148 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995010149 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 1246995010150 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 1246995010151 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1246995010152 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 1246995010153 catalytic residues [active] 1246995010154 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1246995010155 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1246995010156 Cupin domain; Region: Cupin_2; pfam07883 1246995010157 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1246995010158 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1246995010159 intersubunit interface [polypeptide binding]; other site 1246995010160 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995010161 anchored repeat-type ABC transporter, ATP-binding subunit; Region: anch_rpt_ABC; TIGR03771 1246995010162 Walker A/P-loop; other site 1246995010163 ATP binding site [chemical binding]; other site 1246995010164 Q-loop/lid; other site 1246995010165 ABC transporter signature motif; other site 1246995010166 Walker B; other site 1246995010167 D-loop; other site 1246995010168 H-loop/switch region; other site 1246995010169 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1246995010170 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1246995010171 dimer interface [polypeptide binding]; other site 1246995010172 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1246995010173 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1246995010174 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1246995010175 dimerization interface [polypeptide binding]; other site 1246995010176 putative DNA binding site [nucleotide binding]; other site 1246995010177 putative Zn2+ binding site [ion binding]; other site 1246995010178 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 1246995010179 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1246995010180 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1246995010181 putative sugar binding sites [chemical binding]; other site 1246995010182 Q-X-W motif; other site 1246995010183 potential frameshift: common BLAST hit: gi|383780633|ref|YP_005465199.1| putative serine/threonine protein kinase 1246995010184 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 1246995010185 hypothetical protein; Provisional; Region: PRK07338 1246995010186 metal binding site [ion binding]; metal-binding site 1246995010187 dimer interface [polypeptide binding]; other site 1246995010188 Uncharacterized conserved protein [Function unknown]; Region: COG3375 1246995010189 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 1246995010190 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 1246995010191 active site 1246995010192 octamer interface [polypeptide binding]; other site 1246995010193 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1246995010194 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1246995010195 SWIM zinc finger; Region: SWIM; pfam04434 1246995010196 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 1246995010197 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 1246995010198 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1246995010199 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1246995010200 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1246995010201 active site 1246995010202 metal binding site [ion binding]; metal-binding site 1246995010203 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 1246995010204 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1246995010205 translocation protein TolB; Provisional; Region: tolB; PRK04922 1246995010206 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 1246995010207 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995010208 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1246995010209 DNA binding residues [nucleotide binding] 1246995010210 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1246995010211 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1246995010212 metal binding site [ion binding]; metal-binding site 1246995010213 active site 1246995010214 I-site; other site 1246995010215 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1246995010216 Cellulose binding domain; Region: CBM_2; pfam00553 1246995010217 Cellulose binding domain; Region: CBM_2; pfam00553 1246995010218 Cellulose binding domain; Region: CBM_2; pfam00553 1246995010219 Glycosyl hydrolase family 48; Region: Glyco_hydro_48; pfam02011 1246995010220 Chitin binding domain; Region: Chitin_bind_3; pfam03067 1246995010221 Cellulose binding domain; Region: CBM_2; pfam00553 1246995010222 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1246995010223 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1246995010224 DNA binding site [nucleotide binding] 1246995010225 domain linker motif; other site 1246995010226 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 1246995010227 ligand binding site [chemical binding]; other site 1246995010228 dimerization interface (open form) [polypeptide binding]; other site 1246995010229 dimerization interface (closed form) [polypeptide binding]; other site 1246995010230 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 1246995010231 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1246995010232 putative ligand binding site [chemical binding]; other site 1246995010233 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1246995010234 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1246995010235 Walker A/P-loop; other site 1246995010236 ATP binding site [chemical binding]; other site 1246995010237 Q-loop/lid; other site 1246995010238 ABC transporter signature motif; other site 1246995010239 Walker B; other site 1246995010240 D-loop; other site 1246995010241 H-loop/switch region; other site 1246995010242 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1246995010243 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1246995010244 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1246995010245 TM-ABC transporter signature motif; other site 1246995010246 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1246995010247 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1246995010248 TM-ABC transporter signature motif; other site 1246995010249 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1246995010250 nucleoside/Zn binding site; other site 1246995010251 dimer interface [polypeptide binding]; other site 1246995010252 catalytic motif [active] 1246995010253 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1246995010254 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1246995010255 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1246995010256 H+ Antiporter protein; Region: 2A0121; TIGR00900 1246995010257 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 1246995010258 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1246995010259 putative substrate translocation pore; other site 1246995010260 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995010261 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995010262 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1246995010263 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1246995010264 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1246995010265 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1246995010266 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 1246995010267 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1246995010268 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1246995010269 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1246995010270 Walker A motif; other site 1246995010271 ATP binding site [chemical binding]; other site 1246995010272 Walker B motif; other site 1246995010273 arginine finger; other site 1246995010274 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 1246995010275 Leucine-rich repeats; other site 1246995010276 Substrate binding site [chemical binding]; other site 1246995010277 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995010278 NAD(P) binding site [chemical binding]; other site 1246995010279 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1246995010280 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995010281 active site 1246995010282 potential frameshift: common BLAST hit: gi|379738131|ref|YP_005331637.1| Xanthine dehydrogenase maturation factor 1246995010283 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1246995010284 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1246995010285 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1246995010286 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 1246995010287 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 1246995010288 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1246995010289 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1246995010290 catalytic loop [active] 1246995010291 iron binding site [ion binding]; other site 1246995010292 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1246995010293 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1246995010294 2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514 1246995010295 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995010296 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995010297 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1246995010298 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1246995010299 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1246995010300 Cytokine receptor motif; other site 1246995010301 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 1246995010302 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1246995010303 active site 1246995010304 metal binding site [ion binding]; metal-binding site 1246995010305 hexamer interface [polypeptide binding]; other site 1246995010306 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12854 1246995010307 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1246995010308 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1246995010309 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 1246995010310 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1246995010311 conserved cys residue [active] 1246995010312 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1246995010313 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1246995010314 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1246995010315 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1246995010316 active site 1246995010317 metal binding site [ion binding]; metal-binding site 1246995010318 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1246995010319 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1246995010320 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1246995010321 DNA binding residues [nucleotide binding] 1246995010322 Archaeal/vacuolar-type H+-ATPase subunit H [Energy production and conversion]; Region: NtpF; COG2811 1246995010323 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1246995010324 metal binding site [ion binding]; metal-binding site 1246995010325 active site 1246995010326 I-site; other site 1246995010327 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1246995010328 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 1246995010329 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1246995010330 S-adenosylmethionine binding site [chemical binding]; other site 1246995010331 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 1246995010332 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1246995010333 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 1246995010334 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1246995010335 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1246995010336 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1246995010337 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1246995010338 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1246995010339 active site 1246995010340 catalytic tetrad [active] 1246995010341 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 1246995010342 Domain of unknown function (DUF305); Region: DUF305; pfam03713 1246995010343 PAS fold; Region: PAS_4; pfam08448 1246995010344 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1246995010345 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1246995010346 metal binding site [ion binding]; metal-binding site 1246995010347 active site 1246995010348 I-site; other site 1246995010349 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1246995010350 Uncharacterized conserved protein [Function unknown]; Region: COG4095 1246995010351 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1246995010352 adenosine deaminase; Provisional; Region: PRK09358 1246995010353 active site 1246995010354 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 1246995010355 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cl00237 1246995010356 putative substrate binding pocket [chemical binding]; other site 1246995010357 AC domain interface; other site 1246995010358 catalytic triad [active] 1246995010359 AB domain interface; other site 1246995010360 interchain disulfide; other site 1246995010361 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 1246995010362 B3/4 domain; Region: B3_4; pfam03483 1246995010363 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1246995010364 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1246995010365 DNA-binding site [nucleotide binding]; DNA binding site 1246995010366 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1246995010367 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1246995010368 homodimer interface [polypeptide binding]; other site 1246995010369 catalytic residue [active] 1246995010370 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1246995010371 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1246995010372 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1246995010373 dimerization interface [polypeptide binding]; other site 1246995010374 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1246995010375 dimer interface [polypeptide binding]; other site 1246995010376 phosphorylation site [posttranslational modification] 1246995010377 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995010378 Mg2+ binding site [ion binding]; other site 1246995010379 G-X-G motif; other site 1246995010380 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1246995010381 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995010382 active site 1246995010383 phosphorylation site [posttranslational modification] 1246995010384 intermolecular recognition site; other site 1246995010385 dimerization interface [polypeptide binding]; other site 1246995010386 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1246995010387 DNA binding site [nucleotide binding] 1246995010388 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1246995010389 anti sigma factor interaction site; other site 1246995010390 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1246995010391 regulatory phosphorylation site [posttranslational modification]; other site 1246995010392 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1246995010393 anti sigma factor interaction site; other site 1246995010394 regulatory phosphorylation site [posttranslational modification]; other site 1246995010395 GAF domain; Region: GAF; cl17456 1246995010396 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1246995010397 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1246995010398 metal binding site [ion binding]; metal-binding site 1246995010399 active site 1246995010400 I-site; other site 1246995010401 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 1246995010402 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1246995010403 Bacterial transcriptional regulator; Region: IclR; pfam01614 1246995010404 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1246995010405 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1246995010406 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 1246995010407 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 1246995010408 tetramer interface [polypeptide binding]; other site 1246995010409 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 1246995010410 active site 1246995010411 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 1246995010412 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 1246995010413 active site 1246995010414 Coenzyme A transferase; Region: CoA_trans; cl17247 1246995010415 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1246995010416 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 1246995010417 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1246995010418 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1246995010419 NMT1/THI5 like; Region: NMT1; pfam09084 1246995010420 membrane-bound complex binding site; other site 1246995010421 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1246995010422 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1246995010423 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1246995010424 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1246995010425 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1246995010426 Walker A/P-loop; other site 1246995010427 ATP binding site [chemical binding]; other site 1246995010428 Q-loop/lid; other site 1246995010429 ABC transporter signature motif; other site 1246995010430 Walker B; other site 1246995010431 D-loop; other site 1246995010432 H-loop/switch region; other site 1246995010433 succinic semialdehyde dehydrogenase; Region: PLN02278 1246995010434 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1246995010435 NAD(P) binding site [chemical binding]; other site 1246995010436 catalytic residues [active] 1246995010437 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1246995010438 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1246995010439 Predicted transcriptional regulator [Transcription]; Region: COG2378 1246995010440 HTH domain; Region: HTH_11; pfam08279 1246995010441 WYL domain; Region: WYL; pfam13280 1246995010442 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1246995010443 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995010444 dimer interface [polypeptide binding]; other site 1246995010445 conserved gate region; other site 1246995010446 putative PBP binding loops; other site 1246995010447 ABC-ATPase subunit interface; other site 1246995010448 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1246995010449 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995010450 dimer interface [polypeptide binding]; other site 1246995010451 putative PBP binding loops; other site 1246995010452 ABC-ATPase subunit interface; other site 1246995010453 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1246995010454 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1246995010455 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 1246995010456 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 1246995010457 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1246995010458 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1246995010459 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1246995010460 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 1246995010461 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1246995010462 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1246995010463 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1246995010464 NAD binding site [chemical binding]; other site 1246995010465 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1246995010466 Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_euk_AmyA; cd11317 1246995010467 active site 1246995010468 Ca binding site [ion binding]; other site 1246995010469 catalytic site [active] 1246995010470 Aamy_C domain; Region: Aamy_C; smart00632 1246995010471 Alpha-amylase, C-terminal CBM20 (carbohydrate-binding module, family 20) domain. This domain is found in several bacterial and fungal alpha-amylases including the maltopentaose-forming amylases (G5-amylases). Most alpha-amylases have, in addition to the...; Region: CBM20_alpha_amylase; cd05808 1246995010472 starch-binding site 2 [chemical binding]; other site 1246995010473 starch-binding site 1 [chemical binding]; other site 1246995010474 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1246995010475 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1246995010476 DNA binding site [nucleotide binding] 1246995010477 domain linker motif; other site 1246995010478 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_10; cd06292 1246995010479 putative dimerization interface [polypeptide binding]; other site 1246995010480 putative ligand binding site [chemical binding]; other site 1246995010481 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 1246995010482 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1246995010483 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995010484 dimer interface [polypeptide binding]; other site 1246995010485 conserved gate region; other site 1246995010486 ABC-ATPase subunit interface; other site 1246995010487 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1246995010488 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995010489 dimer interface [polypeptide binding]; other site 1246995010490 conserved gate region; other site 1246995010491 putative PBP binding loops; other site 1246995010492 ABC-ATPase subunit interface; other site 1246995010493 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1246995010494 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 1246995010495 putative NAD(P) binding site [chemical binding]; other site 1246995010496 Predicted transcriptional regulators [Transcription]; Region: COG1695 1246995010497 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1246995010498 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995010499 SnoaL-like domain; Region: SnoaL_2; pfam12680 1246995010500 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1246995010501 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1246995010502 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1246995010503 putative substrate translocation pore; other site 1246995010504 MarR family; Region: MarR; pfam01047 1246995010505 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1246995010506 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1246995010507 active site 1246995010508 catalytic tetrad [active] 1246995010509 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1246995010510 POT family; Region: PTR2; cl17359 1246995010511 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 1246995010512 Thioredoxin; Region: Thioredoxin_4; pfam13462 1246995010513 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1246995010514 Beta-lactamase; Region: Beta-lactamase; pfam00144 1246995010515 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1246995010516 VanZ like family; Region: VanZ; cl01971 1246995010517 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1246995010518 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995010519 active site 1246995010520 phosphorylation site [posttranslational modification] 1246995010521 intermolecular recognition site; other site 1246995010522 dimerization interface [polypeptide binding]; other site 1246995010523 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1246995010524 DNA binding site [nucleotide binding] 1246995010525 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1246995010526 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1246995010527 dimerization interface [polypeptide binding]; other site 1246995010528 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1246995010529 dimer interface [polypeptide binding]; other site 1246995010530 phosphorylation site [posttranslational modification] 1246995010531 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995010532 ATP binding site [chemical binding]; other site 1246995010533 Mg2+ binding site [ion binding]; other site 1246995010534 G-X-G motif; other site 1246995010535 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 1246995010536 TopoisomeraseII; Region: TOP2c; smart00433 1246995010537 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1246995010538 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1246995010539 active site 1246995010540 hypothetical protein; Provisional; Region: PRK04194 1246995010541 AIR carboxylase; Region: AIRC; smart01001 1246995010542 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 1246995010543 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 1246995010544 Ligand Binding Site [chemical binding]; other site 1246995010545 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1246995010546 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1246995010547 DNA binding site [nucleotide binding] 1246995010548 domain linker motif; other site 1246995010549 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1246995010550 dimerization interface [polypeptide binding]; other site 1246995010551 ligand binding site [chemical binding]; other site 1246995010552 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995010553 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995010554 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 1246995010555 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1246995010556 dimer interface [polypeptide binding]; other site 1246995010557 active site 1246995010558 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1246995010559 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1246995010560 Walker A/P-loop; other site 1246995010561 ATP binding site [chemical binding]; other site 1246995010562 Q-loop/lid; other site 1246995010563 ABC transporter signature motif; other site 1246995010564 Walker B; other site 1246995010565 D-loop; other site 1246995010566 H-loop/switch region; other site 1246995010567 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 1246995010568 PDGLE domain; Region: PDGLE; pfam13190 1246995010569 ABC-type Co2+ transport system, permease component [Inorganic ion transport and metabolism]; Region: CbiM; COG0310 1246995010570 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 1246995010571 CO dehydrogenase maturation factor [Cell division and chromosome partitioning]; Region: CooC; COG3640 1246995010572 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1246995010573 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1246995010574 SmpB-tmRNA interface; other site 1246995010575 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1246995010576 Cellulose binding domain; Region: CBM_2; pfam00553 1246995010577 SGNH_hydrolase subfamily, similar to Ruminococcus flavefaciens XynB. Most likely a secreted hydrolase with xylanase activity. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from...; Region: XynB_like; cd01833 1246995010578 active site 1246995010579 catalytic triad [active] 1246995010580 oxyanion hole [active] 1246995010581 Cellulose binding domain; Region: CBM_2; pfam00553 1246995010582 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 1246995010583 metal binding site [ion binding]; metal-binding site 1246995010584 active site 1246995010585 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 1246995010586 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995010587 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1246995010588 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1246995010589 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 1246995010590 Cysteine-rich domain; Region: CCG; pfam02754 1246995010591 Cysteine-rich domain; Region: CCG; pfam02754 1246995010592 FAD binding domain; Region: FAD_binding_4; pfam01565 1246995010593 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1246995010594 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 1246995010595 FAD binding domain; Region: FAD_binding_4; pfam01565 1246995010596 Fungalysin metallopeptidase (M36); Region: Peptidase_M36; pfam02128 1246995010597 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 1246995010598 Zn binding site [ion binding]; other site 1246995010599 Predicted integral membrane proteins containing uncharacterized repeats [Function unknown]; Region: COG5563 1246995010600 probable extracellular repeat, HAF family; Region: HAF_rpt; TIGR02913 1246995010601 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 1246995010602 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 1246995010603 NAD binding site [chemical binding]; other site 1246995010604 catalytic Zn binding site [ion binding]; other site 1246995010605 structural Zn binding site [ion binding]; other site 1246995010606 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1246995010607 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1246995010608 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1246995010609 active site 1246995010610 Zn binding site [ion binding]; other site 1246995010611 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1246995010612 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1246995010613 dimer interface [polypeptide binding]; other site 1246995010614 active site 1246995010615 CoA binding pocket [chemical binding]; other site 1246995010616 YCII-related domain; Region: YCII; cl00999 1246995010617 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 1246995010618 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995010619 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1246995010620 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1246995010621 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1246995010622 N-terminal domain interface [polypeptide binding]; other site 1246995010623 dimer interface [polypeptide binding]; other site 1246995010624 substrate binding pocket (H-site) [chemical binding]; other site 1246995010625 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 1246995010626 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1246995010627 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1246995010628 S-adenosylmethionine binding site [chemical binding]; other site 1246995010629 SnoaL-like domain; Region: SnoaL_3; pfam13474 1246995010630 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 1246995010631 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995010632 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1246995010633 NAD(P) binding site [chemical binding]; other site 1246995010634 active site 1246995010635 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 1246995010636 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1246995010637 ATP binding site [chemical binding]; other site 1246995010638 putative Mg++ binding site [ion binding]; other site 1246995010639 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1246995010640 nucleotide binding region [chemical binding]; other site 1246995010641 ATP-binding site [chemical binding]; other site 1246995010642 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1246995010643 HRDC domain; Region: HRDC; pfam00570 1246995010644 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 1246995010645 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1246995010646 TAP-like protein; Region: Abhydrolase_4; pfam08386 1246995010647 PAS fold; Region: PAS_4; pfam08448 1246995010648 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1246995010649 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1246995010650 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1246995010651 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1246995010652 anti sigma factor interaction site; other site 1246995010653 regulatory phosphorylation site [posttranslational modification]; other site 1246995010654 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1246995010655 dimerization interface [polypeptide binding]; other site 1246995010656 active site 1246995010657 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 1246995010658 RibD C-terminal domain; Region: RibD_C; cl17279 1246995010659 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 1246995010660 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1246995010661 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1246995010662 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 1246995010663 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1246995010664 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 1246995010665 putative NAD(P) binding site [chemical binding]; other site 1246995010666 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1246995010667 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1246995010668 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1246995010669 intersubunit interface [polypeptide binding]; other site 1246995010670 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1246995010671 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1246995010672 Putative esterase; Region: Esterase; pfam00756 1246995010673 S-formylglutathione hydrolase; Region: PLN02442 1246995010674 xanthine permease; Region: pbuX; TIGR03173 1246995010675 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1246995010676 active site 1246995010677 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1246995010678 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1246995010679 DNA binding residues [nucleotide binding] 1246995010680 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1246995010681 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1246995010682 Coenzyme A binding pocket [chemical binding]; other site 1246995010683 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1246995010684 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 1246995010685 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 1246995010686 Zn binding site [ion binding]; other site 1246995010687 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1246995010688 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1246995010689 Coenzyme A binding pocket [chemical binding]; other site 1246995010690 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 1246995010691 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 1246995010692 FAD binding pocket [chemical binding]; other site 1246995010693 FAD binding motif [chemical binding]; other site 1246995010694 phosphate binding motif [ion binding]; other site 1246995010695 beta-alpha-beta structure motif; other site 1246995010696 NAD binding pocket [chemical binding]; other site 1246995010697 heat shock protein 90; Provisional; Region: PRK05218 1246995010698 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995010699 ATP binding site [chemical binding]; other site 1246995010700 Mg2+ binding site [ion binding]; other site 1246995010701 G-X-G motif; other site 1246995010702 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995010703 WHG domain; Region: WHG; pfam13305 1246995010704 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1246995010705 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1246995010706 NAD(P) binding site [chemical binding]; other site 1246995010707 substrate binding site [chemical binding]; other site 1246995010708 dimer interface [polypeptide binding]; other site 1246995010709 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1246995010710 MarR family; Region: MarR; pfam01047 1246995010711 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1246995010712 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1246995010713 Integrin alpha; Region: Integrin_alpha2; pfam08441 1246995010714 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1246995010715 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1246995010716 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1246995010717 ATP binding site [chemical binding]; other site 1246995010718 substrate binding site [chemical binding]; other site 1246995010719 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 1246995010720 active site 1246995010721 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1246995010722 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1246995010723 putative substrate translocation pore; other site 1246995010724 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1246995010725 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1246995010726 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995010727 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995010728 short chain dehydrogenase; Validated; Region: PRK08264 1246995010729 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995010730 NAD(P) binding site [chemical binding]; other site 1246995010731 active site 1246995010732 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1246995010733 GntP family permease; Region: GntP_permease; pfam02447 1246995010734 FtsX-like permease family; Region: FtsX; pfam02687 1246995010735 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1246995010736 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1246995010737 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1246995010738 Walker A/P-loop; other site 1246995010739 ATP binding site [chemical binding]; other site 1246995010740 Q-loop/lid; other site 1246995010741 ABC transporter signature motif; other site 1246995010742 Walker B; other site 1246995010743 D-loop; other site 1246995010744 H-loop/switch region; other site 1246995010745 Putative sensor; Region: Sensor; pfam13796 1246995010746 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1246995010747 Histidine kinase; Region: HisKA_3; pfam07730 1246995010748 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995010749 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995010750 phosphorylation site [posttranslational modification] 1246995010751 intermolecular recognition site; other site 1246995010752 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995010753 DNA binding residues [nucleotide binding] 1246995010754 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 1246995010755 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1246995010756 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1246995010757 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1246995010758 Transglycosylase; Region: Transgly; pfam00912 1246995010759 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1246995010760 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1246995010761 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995010762 active site 1246995010763 phosphorylation site [posttranslational modification] 1246995010764 intermolecular recognition site; other site 1246995010765 dimerization interface [polypeptide binding]; other site 1246995010766 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 1246995010767 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1246995010768 PAS domain; Region: PAS; smart00091 1246995010769 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995010770 ATP binding site [chemical binding]; other site 1246995010771 G-X-G motif; other site 1246995010772 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1246995010773 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1246995010774 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1246995010775 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1246995010776 DNA binding site [nucleotide binding] 1246995010777 domain linker motif; other site 1246995010778 Ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation; Region: PBP1_CatR_like; cd06296 1246995010779 putative dimerization interface [polypeptide binding]; other site 1246995010780 putative ligand binding site [chemical binding]; other site 1246995010781 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; pfam04734 1246995010782 Laminin G domain; Region: LamG; smart00282 1246995010783 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1246995010784 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1246995010785 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995010786 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1246995010787 DNA binding residues [nucleotide binding] 1246995010788 Uncharacterized glycoside hydrolase family 99-like domain; Region: GH99_GH71_like_2; cd11576 1246995010789 putative ligand binding site [chemical binding]; other site 1246995010790 putative catalytic site [active] 1246995010791 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1246995010792 sugar binding site [chemical binding]; other site 1246995010793 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1246995010794 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1246995010795 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1246995010796 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1246995010797 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1246995010798 helix_turn_helix, mercury resistance; Region: HTH_MERR; smart00422 1246995010799 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1246995010800 DNA binding residues [nucleotide binding] 1246995010801 MerR, DNA binding; Region: MerR-DNA-bind; pfam09278 1246995010802 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1246995010803 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1246995010804 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 1246995010805 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 1246995010806 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995010807 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1246995010808 DNA binding residues [nucleotide binding] 1246995010809 Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224 1246995010810 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 1246995010811 Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324 1246995010812 NADP binding site [chemical binding]; other site 1246995010813 substrate binding site [chemical binding]; other site 1246995010814 active site 1246995010815 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1246995010816 dihydropteroate synthase; Region: DHPS; TIGR01496 1246995010817 substrate binding pocket [chemical binding]; other site 1246995010818 dimer interface [polypeptide binding]; other site 1246995010819 inhibitor binding site; inhibition site 1246995010820 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1246995010821 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995010822 Q-loop/lid; other site 1246995010823 ABC transporter signature motif; other site 1246995010824 Walker B; other site 1246995010825 D-loop; other site 1246995010826 H-loop/switch region; other site 1246995010827 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1246995010828 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1246995010829 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995010830 Walker A/P-loop; other site 1246995010831 ATP binding site [chemical binding]; other site 1246995010832 Q-loop/lid; other site 1246995010833 ABC transporter signature motif; other site 1246995010834 Walker B; other site 1246995010835 D-loop; other site 1246995010836 H-loop/switch region; other site 1246995010837 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1246995010838 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 1246995010839 Moco binding site; other site 1246995010840 metal coordination site [ion binding]; other site 1246995010841 dimerization interface [polypeptide binding]; other site 1246995010842 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 1246995010843 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 1246995010844 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 1246995010845 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1246995010846 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 1246995010847 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1246995010848 ChaB; Region: ChaB; pfam06150 1246995010849 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 1246995010850 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1246995010851 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1246995010852 non-specific DNA binding site [nucleotide binding]; other site 1246995010853 salt bridge; other site 1246995010854 sequence-specific DNA binding site [nucleotide binding]; other site 1246995010855 Cupin domain; Region: Cupin_2; pfam07883 1246995010856 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1246995010857 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1246995010858 metal binding site [ion binding]; metal-binding site 1246995010859 active site 1246995010860 I-site; other site 1246995010861 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1246995010862 ?-D-glucose-1-phosphatase; Provisional; Region: PRK09456 1246995010863 Secretory lipase; Region: LIP; pfam03583 1246995010864 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1246995010865 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1246995010866 active site 1246995010867 ATP binding site [chemical binding]; other site 1246995010868 substrate binding site [chemical binding]; other site 1246995010869 activation loop (A-loop); other site 1246995010870 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1246995010871 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995010872 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 1246995010873 Walker A/P-loop; other site 1246995010874 ATP binding site [chemical binding]; other site 1246995010875 Q-loop/lid; other site 1246995010876 ABC transporter signature motif; other site 1246995010877 Walker B; other site 1246995010878 D-loop; other site 1246995010879 H-loop/switch region; other site 1246995010880 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995010881 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 1246995010882 Walker A/P-loop; other site 1246995010883 ATP binding site [chemical binding]; other site 1246995010884 ABC transporter signature motif; other site 1246995010885 Walker B; other site 1246995010886 D-loop; other site 1246995010887 H-loop/switch region; other site 1246995010888 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1246995010889 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1246995010890 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1246995010891 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1246995010892 Penicillinase repressor; Region: Pencillinase_R; pfam03965 1246995010893 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1246995010894 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1246995010895 NlpC/P60 family; Region: NLPC_P60; pfam00877 1246995010896 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; pfam04655 1246995010897 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1246995010898 MarR family; Region: MarR_2; pfam12802 1246995010899 Epoxide hydrolase N terminus; Region: EHN; pfam06441 1246995010900 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1246995010901 PAS domain S-box; Region: sensory_box; TIGR00229 1246995010902 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1246995010903 putative active site [active] 1246995010904 heme pocket [chemical binding]; other site 1246995010905 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1246995010906 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1246995010907 metal binding site [ion binding]; metal-binding site 1246995010908 active site 1246995010909 I-site; other site 1246995010910 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1246995010911 classical (c) SDRs; Region: SDR_c; cd05233 1246995010912 NAD(P) binding site [chemical binding]; other site 1246995010913 active site 1246995010914 CGNR zinc finger; Region: zf-CGNR; pfam11706 1246995010915 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1246995010916 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1246995010917 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 1246995010918 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1246995010919 Walker A motif; other site 1246995010920 ATP binding site [chemical binding]; other site 1246995010921 Walker B motif; other site 1246995010922 arginine finger; other site 1246995010923 YibE/F-like protein; Region: YibE_F; pfam07907 1246995010924 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1246995010925 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1246995010926 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1246995010927 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1246995010928 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1246995010929 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1246995010930 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1246995010931 dimerization interface [polypeptide binding]; other site 1246995010932 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 1246995010933 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1246995010934 potential catalytic triad [active] 1246995010935 conserved cys residue [active] 1246995010936 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1246995010937 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1246995010938 DNA-binding site [nucleotide binding]; DNA binding site 1246995010939 UTRA domain; Region: UTRA; pfam07702 1246995010940 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1246995010941 substrate binding site [chemical binding]; other site 1246995010942 active site 1246995010943 catalytic residues [active] 1246995010944 heterodimer interface [polypeptide binding]; other site 1246995010945 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1246995010946 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1246995010947 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1246995010948 catalytic residue [active] 1246995010949 Stf0 sulphotransferase; Region: Sulphotransf; cl01835 1246995010950 Clp amino terminal domain; Region: Clp_N; pfam02861 1246995010951 Clp amino terminal domain; Region: Clp_N; pfam02861 1246995010952 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995010953 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995010954 active site 1246995010955 phosphorylation site [posttranslational modification] 1246995010956 intermolecular recognition site; other site 1246995010957 dimerization interface [polypeptide binding]; other site 1246995010958 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995010959 dimerization interface [polypeptide binding]; other site 1246995010960 DNA binding residues [nucleotide binding] 1246995010961 Histidine kinase; Region: HisKA_3; pfam07730 1246995010962 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1246995010963 ATP binding site [chemical binding]; other site 1246995010964 Mg2+ binding site [ion binding]; other site 1246995010965 G-X-G motif; other site 1246995010966 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1246995010967 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1246995010968 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 1246995010969 Predicted transcriptional regulators [Transcription]; Region: COG1733 1246995010970 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1246995010971 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1246995010972 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1246995010973 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1246995010974 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995010975 Walker A/P-loop; other site 1246995010976 ATP binding site [chemical binding]; other site 1246995010977 Q-loop/lid; other site 1246995010978 ABC transporter signature motif; other site 1246995010979 Walker B; other site 1246995010980 D-loop; other site 1246995010981 H-loop/switch region; other site 1246995010982 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 1246995010983 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1246995010984 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995010985 active site 1246995010986 phosphorylation site [posttranslational modification] 1246995010987 intermolecular recognition site; other site 1246995010988 dimerization interface [polypeptide binding]; other site 1246995010989 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1246995010990 DNA binding site [nucleotide binding] 1246995010991 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1246995010992 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1246995010993 dimerization interface [polypeptide binding]; other site 1246995010994 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1246995010995 dimer interface [polypeptide binding]; other site 1246995010996 phosphorylation site [posttranslational modification] 1246995010997 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995010998 ATP binding site [chemical binding]; other site 1246995010999 Mg2+ binding site [ion binding]; other site 1246995011000 G-X-G motif; other site 1246995011001 Protein of unknown function (DUF429); Region: DUF429; cl12046 1246995011002 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1246995011003 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1246995011004 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1246995011005 S-adenosylmethionine binding site [chemical binding]; other site 1246995011006 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 1246995011007 Hemerythrin-like domain; Region: Hr-like; cd12108 1246995011008 Fe binding site [ion binding]; other site 1246995011009 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 1246995011010 putative hydrophobic ligand binding site [chemical binding]; other site 1246995011011 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1246995011012 dimerization interface [polypeptide binding]; other site 1246995011013 putative DNA binding site [nucleotide binding]; other site 1246995011014 putative Zn2+ binding site [ion binding]; other site 1246995011015 Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041 1246995011016 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995011017 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995011018 active site 1246995011019 phosphorylation site [posttranslational modification] 1246995011020 intermolecular recognition site; other site 1246995011021 dimerization interface [polypeptide binding]; other site 1246995011022 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995011023 DNA binding residues [nucleotide binding] 1246995011024 dimerization interface [polypeptide binding]; other site 1246995011025 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1246995011026 ATP binding site [chemical binding]; other site 1246995011027 Mg2+ binding site [ion binding]; other site 1246995011028 G-X-G motif; other site 1246995011029 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1246995011030 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1246995011031 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1246995011032 FMN binding site [chemical binding]; other site 1246995011033 substrate binding site [chemical binding]; other site 1246995011034 putative catalytic residue [active] 1246995011035 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1246995011036 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1246995011037 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1246995011038 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1246995011039 metal binding site [ion binding]; metal-binding site 1246995011040 active site 1246995011041 I-site; other site 1246995011042 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1246995011043 hydroperoxidase II; Provisional; Region: katE; PRK11249 1246995011044 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 1246995011045 heme binding pocket [chemical binding]; other site 1246995011046 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 1246995011047 domain interactions; other site 1246995011048 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1246995011049 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1246995011050 catalytic site [active] 1246995011051 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_6; cd01844 1246995011052 active site 1246995011053 catalytic triad [active] 1246995011054 oxyanion hole [active] 1246995011055 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1246995011056 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1246995011057 Walker A/P-loop; other site 1246995011058 ATP binding site [chemical binding]; other site 1246995011059 Q-loop/lid; other site 1246995011060 ABC transporter signature motif; other site 1246995011061 Walker B; other site 1246995011062 D-loop; other site 1246995011063 H-loop/switch region; other site 1246995011064 NIL domain; Region: NIL; pfam09383 1246995011065 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995011066 dimer interface [polypeptide binding]; other site 1246995011067 conserved gate region; other site 1246995011068 ABC-ATPase subunit interface; other site 1246995011069 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1246995011070 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1246995011071 MarR family; Region: MarR; pfam01047 1246995011072 DoxX-like family; Region: DoxX_2; pfam13564 1246995011073 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1246995011074 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1246995011075 active site 1246995011076 dimer interface [polypeptide binding]; other site 1246995011077 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1246995011078 dimer interface [polypeptide binding]; other site 1246995011079 active site 1246995011080 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1246995011081 M26 IgA1-specific Metallo-endopeptidase C-terminal region; Region: Peptidase_M26_C; pfam07580 1246995011082 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 1246995011083 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 1246995011084 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 1246995011085 active site 1246995011086 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1246995011087 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 1246995011088 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1246995011089 LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037 1246995011090 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1246995011091 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1246995011092 catalytic core [active] 1246995011093 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995011094 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995011095 short chain dehydrogenase; Provisional; Region: PRK06523 1246995011096 classical (c) SDRs; Region: SDR_c; cd05233 1246995011097 NAD(P) binding site [chemical binding]; other site 1246995011098 active site 1246995011099 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 1246995011100 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1246995011101 non-specific DNA interactions [nucleotide binding]; other site 1246995011102 DNA binding site [nucleotide binding] 1246995011103 sequence specific DNA binding site [nucleotide binding]; other site 1246995011104 putative cAMP binding site [chemical binding]; other site 1246995011105 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1246995011106 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1246995011107 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1246995011108 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1246995011109 putative substrate translocation pore; other site 1246995011110 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 1246995011111 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 1246995011112 metal binding site [ion binding]; metal-binding site 1246995011113 substrate binding pocket [chemical binding]; other site 1246995011114 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1246995011115 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995011116 dimer interface [polypeptide binding]; other site 1246995011117 conserved gate region; other site 1246995011118 putative PBP binding loops; other site 1246995011119 ABC-ATPase subunit interface; other site 1246995011120 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1246995011121 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1246995011122 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995011123 dimer interface [polypeptide binding]; other site 1246995011124 ABC-ATPase subunit interface; other site 1246995011125 putative PBP binding loops; other site 1246995011126 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1246995011127 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995011128 Walker A/P-loop; other site 1246995011129 ATP binding site [chemical binding]; other site 1246995011130 Q-loop/lid; other site 1246995011131 ABC transporter signature motif; other site 1246995011132 Walker B; other site 1246995011133 D-loop; other site 1246995011134 H-loop/switch region; other site 1246995011135 TOBE domain; Region: TOBE_2; pfam08402 1246995011136 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 1246995011137 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1246995011138 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1246995011139 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1246995011140 DNA binding site [nucleotide binding] 1246995011141 domain linker motif; other site 1246995011142 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1246995011143 dimerization interface [polypeptide binding]; other site 1246995011144 ligand binding site [chemical binding]; other site 1246995011145 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1246995011146 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1246995011147 DNA binding site [nucleotide binding] 1246995011148 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1246995011149 Protein G1; Region: Peptidase_M44; pfam03410 1246995011150 HlyD family secretion protein; Region: HlyD_3; pfam13437 1246995011151 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1246995011152 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995011153 active site 1246995011154 phosphorylation site [posttranslational modification] 1246995011155 intermolecular recognition site; other site 1246995011156 dimerization interface [polypeptide binding]; other site 1246995011157 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1246995011158 DNA binding site [nucleotide binding] 1246995011159 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1246995011160 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1246995011161 dimerization interface [polypeptide binding]; other site 1246995011162 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1246995011163 dimer interface [polypeptide binding]; other site 1246995011164 phosphorylation site [posttranslational modification] 1246995011165 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995011166 ATP binding site [chemical binding]; other site 1246995011167 Mg2+ binding site [ion binding]; other site 1246995011168 G-X-G motif; other site 1246995011169 HlyD family secretion protein; Region: HlyD_3; pfam13437 1246995011170 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1246995011171 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1246995011172 Walker A/P-loop; other site 1246995011173 ATP binding site [chemical binding]; other site 1246995011174 Q-loop/lid; other site 1246995011175 ABC transporter signature motif; other site 1246995011176 Walker B; other site 1246995011177 D-loop; other site 1246995011178 H-loop/switch region; other site 1246995011179 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1246995011180 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1246995011181 FtsX-like permease family; Region: FtsX; pfam02687 1246995011182 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1246995011183 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995011184 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995011185 DNA binding residues [nucleotide binding] 1246995011186 dimerization interface [polypeptide binding]; other site 1246995011187 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1246995011188 active site 1246995011189 Zn binding site [ion binding]; other site 1246995011190 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 1246995011191 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cl00942 1246995011192 aromatic arch; other site 1246995011193 DCoH dimer interaction site [polypeptide binding]; other site 1246995011194 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1246995011195 DCoH tetramer interaction site [polypeptide binding]; other site 1246995011196 substrate binding site [chemical binding]; other site 1246995011197 Integral membrane protein TerC family; Region: TerC; cl10468 1246995011198 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 1246995011199 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1246995011200 putative active site [active] 1246995011201 metal binding site [ion binding]; metal-binding site 1246995011202 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 1246995011203 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 1246995011204 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 1246995011205 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1246995011206 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1246995011207 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1246995011208 Coenzyme A binding pocket [chemical binding]; other site 1246995011209 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1246995011210 S-adenosylmethionine binding site [chemical binding]; other site 1246995011211 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 1246995011212 transcriptional regulator BetI; Validated; Region: PRK00767 1246995011213 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995011214 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1246995011215 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1246995011216 DNA-binding site [nucleotide binding]; DNA binding site 1246995011217 UTRA domain; Region: UTRA; pfam07702 1246995011218 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1246995011219 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1246995011220 substrate binding site [chemical binding]; other site 1246995011221 ATP binding site [chemical binding]; other site 1246995011222 KduI/IolB family; Region: KduI; pfam04962 1246995011223 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 1246995011224 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1246995011225 PYR/PP interface [polypeptide binding]; other site 1246995011226 dimer interface [polypeptide binding]; other site 1246995011227 TPP binding site [chemical binding]; other site 1246995011228 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1246995011229 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 1246995011230 TPP-binding site; other site 1246995011231 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1246995011232 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1246995011233 tetrameric interface [polypeptide binding]; other site 1246995011234 NAD binding site [chemical binding]; other site 1246995011235 catalytic residues [active] 1246995011236 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1246995011237 Ubiquitin-like proteins; Region: UBQ; cl00155 1246995011238 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 1246995011239 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1246995011240 putative ligand binding site [chemical binding]; other site 1246995011241 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1246995011242 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1246995011243 TM-ABC transporter signature motif; other site 1246995011244 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1246995011245 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995011246 Walker A/P-loop; other site 1246995011247 ATP binding site [chemical binding]; other site 1246995011248 Q-loop/lid; other site 1246995011249 ABC transporter signature motif; other site 1246995011250 Walker B; other site 1246995011251 D-loop; other site 1246995011252 H-loop/switch region; other site 1246995011253 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1246995011254 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1246995011255 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1246995011256 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1246995011257 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1246995011258 Metal-binding active site; metal-binding site 1246995011259 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 1246995011260 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1246995011261 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1246995011262 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1246995011263 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1246995011264 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1246995011265 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1246995011266 ligand binding site [chemical binding]; other site 1246995011267 dimerization interface [polypeptide binding]; other site 1246995011268 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1246995011269 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1246995011270 ligand binding site [chemical binding]; other site 1246995011271 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1246995011272 (2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; cl00782 1246995011273 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1246995011274 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1246995011275 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1246995011276 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1246995011277 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1246995011278 DNA binding site [nucleotide binding] 1246995011279 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1246995011280 ligand binding site [chemical binding]; other site 1246995011281 dimerization interface [polypeptide binding]; other site 1246995011282 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1246995011283 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 1246995011284 acyl-activating enzyme (AAE) consensus motif; other site 1246995011285 AMP binding site [chemical binding]; other site 1246995011286 active site 1246995011287 CoA binding site [chemical binding]; other site 1246995011288 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995011289 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995011290 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1246995011291 CoenzymeA binding site [chemical binding]; other site 1246995011292 subunit interaction site [polypeptide binding]; other site 1246995011293 PHB binding site; other site 1246995011294 phenylacetic acid degradation protein paaN; Region: PaaN_2; TIGR02288 1246995011295 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1246995011296 NAD(P) binding site [chemical binding]; other site 1246995011297 catalytic residues [active] 1246995011298 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 1246995011299 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1246995011300 dimer interface [polypeptide binding]; other site 1246995011301 active site 1246995011302 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1246995011303 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1246995011304 substrate binding site [chemical binding]; other site 1246995011305 oxyanion hole (OAH) forming residues; other site 1246995011306 trimer interface [polypeptide binding]; other site 1246995011307 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 1246995011308 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1246995011309 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1246995011310 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 1246995011311 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 1246995011312 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 1246995011313 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 1246995011314 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 1246995011315 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1246995011316 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 1246995011317 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 1246995011318 FAD binding pocket [chemical binding]; other site 1246995011319 FAD binding motif [chemical binding]; other site 1246995011320 phosphate binding motif [ion binding]; other site 1246995011321 beta-alpha-beta structure motif; other site 1246995011322 NAD(p) ribose binding residues [chemical binding]; other site 1246995011323 NAD binding pocket [chemical binding]; other site 1246995011324 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 1246995011325 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1246995011326 catalytic loop [active] 1246995011327 iron binding site [ion binding]; other site 1246995011328 Cutinase; Region: Cutinase; pfam01083 1246995011329 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1246995011330 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1246995011331 active site 1246995011332 catalytic tetrad [active] 1246995011333 PAS domain S-box; Region: sensory_box; TIGR00229 1246995011334 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1246995011335 putative active site [active] 1246995011336 heme pocket [chemical binding]; other site 1246995011337 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1246995011338 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1246995011339 metal binding site [ion binding]; metal-binding site 1246995011340 active site 1246995011341 I-site; other site 1246995011342 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1246995011343 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1246995011344 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1246995011345 S-adenosylmethionine binding site [chemical binding]; other site 1246995011346 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 1246995011347 active site 1246995011348 putative catalytic site [active] 1246995011349 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 1246995011350 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1246995011351 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995011352 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1246995011353 DNA binding residues [nucleotide binding] 1246995011354 MMPL family; Region: MMPL; pfam03176 1246995011355 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1246995011356 MarR family; Region: MarR_2; pfam12802 1246995011357 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995011358 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995011359 active site 1246995011360 phosphorylation site [posttranslational modification] 1246995011361 intermolecular recognition site; other site 1246995011362 dimerization interface [polypeptide binding]; other site 1246995011363 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995011364 DNA binding residues [nucleotide binding] 1246995011365 dimerization interface [polypeptide binding]; other site 1246995011366 Histidine kinase; Region: HisKA_3; pfam07730 1246995011367 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1246995011368 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995011369 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1246995011370 Walker A/P-loop; other site 1246995011371 ATP binding site [chemical binding]; other site 1246995011372 Q-loop/lid; other site 1246995011373 ABC transporter signature motif; other site 1246995011374 Walker B; other site 1246995011375 D-loop; other site 1246995011376 H-loop/switch region; other site 1246995011377 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1246995011378 Beta-lactamase; Region: Beta-lactamase; pfam00144 1246995011379 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 1246995011380 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1246995011381 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1246995011382 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995011383 dimer interface [polypeptide binding]; other site 1246995011384 conserved gate region; other site 1246995011385 ABC-ATPase subunit interface; other site 1246995011386 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1246995011387 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995011388 Walker A/P-loop; other site 1246995011389 ATP binding site [chemical binding]; other site 1246995011390 Q-loop/lid; other site 1246995011391 ABC transporter signature motif; other site 1246995011392 Walker B; other site 1246995011393 D-loop; other site 1246995011394 H-loop/switch region; other site 1246995011395 TOBE domain; Region: TOBE_2; pfam08402 1246995011396 H+ Antiporter protein; Region: 2A0121; TIGR00900 1246995011397 Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but some...; Region: chitinase_glyco_hydro_19; cd00325 1246995011398 putative sugar binding site [chemical binding]; other site 1246995011399 catalytic residues [active] 1246995011400 Domain of unknown function (DUF4331); Region: DUF4331; pfam14224 1246995011401 Helix-turn-helix domain; Region: HTH_18; pfam12833 1246995011402 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1246995011403 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 1246995011404 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1246995011405 ligand binding site; other site 1246995011406 oligomer interface; other site 1246995011407 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1246995011408 dimer interface [polypeptide binding]; other site 1246995011409 N-terminal domain interface [polypeptide binding]; other site 1246995011410 sulfate 1 binding site; other site 1246995011411 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 1246995011412 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1246995011413 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 1246995011414 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 1246995011415 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1246995011416 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995011417 Walker A/P-loop; other site 1246995011418 ATP binding site [chemical binding]; other site 1246995011419 Q-loop/lid; other site 1246995011420 ABC transporter signature motif; other site 1246995011421 Walker B; other site 1246995011422 D-loop; other site 1246995011423 H-loop/switch region; other site 1246995011424 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1246995011425 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1246995011426 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 1246995011427 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 1246995011428 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1246995011429 metal ion-dependent adhesion site (MIDAS); other site 1246995011430 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1246995011431 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1246995011432 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 1246995011433 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 1246995011434 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1246995011435 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1246995011436 lipoyl attachment site [posttranslational modification]; other site 1246995011437 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1246995011438 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1246995011439 phosphopeptide binding site; other site 1246995011440 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1246995011441 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1246995011442 DNA binding residues [nucleotide binding] 1246995011443 Bifunctional nuclease; Region: DNase-RNase; pfam02577 1246995011444 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1246995011445 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1246995011446 DNA binding residues [nucleotide binding] 1246995011447 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 1246995011448 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995011449 Walker A/P-loop; other site 1246995011450 ATP binding site [chemical binding]; other site 1246995011451 Q-loop/lid; other site 1246995011452 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1246995011453 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995011454 Walker A/P-loop; other site 1246995011455 ATP binding site [chemical binding]; other site 1246995011456 Q-loop/lid; other site 1246995011457 ABC transporter signature motif; other site 1246995011458 Walker B; other site 1246995011459 D-loop; other site 1246995011460 H-loop/switch region; other site 1246995011461 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1246995011462 S-adenosylmethionine binding site [chemical binding]; other site 1246995011463 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1246995011464 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1246995011465 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1246995011466 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 1246995011467 putative dimerization interface [polypeptide binding]; other site 1246995011468 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 1246995011469 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1246995011470 DNA-binding site [nucleotide binding]; DNA binding site 1246995011471 RNA-binding motif; other site 1246995011472 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1246995011473 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1246995011474 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1246995011475 sequence-specific DNA binding site [nucleotide binding]; other site 1246995011476 salt bridge; other site 1246995011477 Cupin domain; Region: Cupin_2; pfam07883 1246995011478 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 1246995011479 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 1246995011480 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1246995011481 active site 1246995011482 dimer interface [polypeptide binding]; other site 1246995011483 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1246995011484 Ligand Binding Site [chemical binding]; other site 1246995011485 Molecular Tunnel; other site 1246995011486 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1246995011487 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995011488 active site 1246995011489 phosphorylation site [posttranslational modification] 1246995011490 intermolecular recognition site; other site 1246995011491 dimerization interface [polypeptide binding]; other site 1246995011492 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1246995011493 DNA binding site [nucleotide binding] 1246995011494 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1246995011495 dimerization interface [polypeptide binding]; other site 1246995011496 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1246995011497 dimer interface [polypeptide binding]; other site 1246995011498 phosphorylation site [posttranslational modification] 1246995011499 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995011500 ATP binding site [chemical binding]; other site 1246995011501 Mg2+ binding site [ion binding]; other site 1246995011502 G-X-G motif; other site 1246995011503 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1246995011504 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1246995011505 ATP binding site [chemical binding]; other site 1246995011506 putative Mg++ binding site [ion binding]; other site 1246995011507 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1246995011508 nucleotide binding region [chemical binding]; other site 1246995011509 ATP-binding site [chemical binding]; other site 1246995011510 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 1246995011511 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973 1246995011512 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 1246995011513 Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417 1246995011514 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1246995011515 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1246995011516 active site 1246995011517 catalytic tetrad [active] 1246995011518 glycine dehydrogenase; Provisional; Region: PRK05367 1246995011519 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1246995011520 tetramer interface [polypeptide binding]; other site 1246995011521 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1246995011522 catalytic residue [active] 1246995011523 Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG1003 1246995011524 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1246995011525 catalytic residue [active] 1246995011526 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1246995011527 DGC domain; Region: DGC; cl01742 1246995011528 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1246995011529 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995011530 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1246995011531 DNA binding residues [nucleotide binding] 1246995011532 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1246995011533 active site 1246995011534 catalytic residues [active] 1246995011535 metal binding site [ion binding]; metal-binding site 1246995011536 Thiopurine S-methyltransferase (TPMT); Region: TPMT; pfam05724 1246995011537 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1246995011538 S-adenosylmethionine binding site [chemical binding]; other site 1246995011539 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1246995011540 nudix motif; other site 1246995011541 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1246995011542 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1246995011543 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1246995011544 catalytic residue [active] 1246995011545 IucA / IucC family; Region: IucA_IucC; pfam04183 1246995011546 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1246995011547 IucA / IucC family; Region: IucA_IucC; pfam04183 1246995011548 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1246995011549 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995011550 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1246995011551 NAD(P) binding site [chemical binding]; other site 1246995011552 active site 1246995011553 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1246995011554 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1246995011555 Walker A/P-loop; other site 1246995011556 ATP binding site [chemical binding]; other site 1246995011557 Q-loop/lid; other site 1246995011558 ABC transporter signature motif; other site 1246995011559 Walker B; other site 1246995011560 D-loop; other site 1246995011561 H-loop/switch region; other site 1246995011562 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1246995011563 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1246995011564 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1246995011565 Histidine kinase; Region: HisKA_3; pfam07730 1246995011566 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995011567 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995011568 active site 1246995011569 phosphorylation site [posttranslational modification] 1246995011570 intermolecular recognition site; other site 1246995011571 dimerization interface [polypeptide binding]; other site 1246995011572 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995011573 DNA binding residues [nucleotide binding] 1246995011574 dimerization interface [polypeptide binding]; other site 1246995011575 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995011576 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 1246995011577 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1246995011578 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1246995011579 DNA binding residues [nucleotide binding] 1246995011580 Predicted transcriptional regulators [Transcription]; Region: COG1695 1246995011581 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1246995011582 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1246995011583 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1246995011584 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995011585 Walker A/P-loop; other site 1246995011586 ATP binding site [chemical binding]; other site 1246995011587 Q-loop/lid; other site 1246995011588 ABC transporter signature motif; other site 1246995011589 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1246995011590 Walker B; other site 1246995011591 D-loop; other site 1246995011592 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1246995011593 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1246995011594 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1246995011595 active site 1246995011596 Int/Topo IB signature motif; other site 1246995011597 DNA binding site [nucleotide binding] 1246995011598 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 1246995011599 Protein of unknown function (DUF3626); Region: DUF3626; pfam12294 1246995011600 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1246995011601 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1246995011602 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995011603 WHG domain; Region: WHG; pfam13305 1246995011604 Cytochrome P450; Region: p450; cl12078 1246995011605 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1246995011606 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1246995011607 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 1246995011608 potential frameshift: common BLAST hit: gi|399539946|ref|YP_006552608.1| epocide hydrolase domain-containing protein 1246995011609 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1246995011610 DNA-binding site [nucleotide binding]; DNA binding site 1246995011611 Vacuole effluxer Atg22 like; Region: ATG22; pfam11700 1246995011612 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1246995011613 Dynamin family; Region: Dynamin_N; pfam00350 1246995011614 G1 box; other site 1246995011615 GTP/Mg2+ binding site [chemical binding]; other site 1246995011616 G2 box; other site 1246995011617 Switch I region; other site 1246995011618 G3 box; other site 1246995011619 Switch II region; other site 1246995011620 G4 box; other site 1246995011621 G5 box; other site 1246995011622 AAA ATPase domain; Region: AAA_16; pfam13191 1246995011623 AAA domain; Region: AAA_22; pfam13401 1246995011624 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995011625 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995011626 DNA binding residues [nucleotide binding] 1246995011627 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1246995011628 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1246995011629 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 1246995011630 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663 1246995011631 SxDxEG motif; other site 1246995011632 active site 1246995011633 metal binding site [ion binding]; metal-binding site 1246995011634 homopentamer interface [polypeptide binding]; other site 1246995011635 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1246995011636 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1246995011637 putative acyl-acceptor binding pocket; other site 1246995011638 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1246995011639 active site 1246995011640 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 1246995011641 MarR family; Region: MarR; pfam01047 1246995011642 short chain dehydrogenase; Provisional; Region: PRK06523 1246995011643 classical (c) SDRs; Region: SDR_c; cd05233 1246995011644 NAD(P) binding site [chemical binding]; other site 1246995011645 active site 1246995011646 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995011647 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995011648 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1246995011649 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1246995011650 S-adenosylmethionine binding site [chemical binding]; other site 1246995011651 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1246995011652 active site 1246995011653 ATP binding site [chemical binding]; other site 1246995011654 Phosphotransferase enzyme family; Region: APH; pfam01636 1246995011655 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995011656 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995011657 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1246995011658 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1246995011659 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1246995011660 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1246995011661 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1246995011662 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1246995011663 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1246995011664 active site 1246995011665 DNA binding site [nucleotide binding] 1246995011666 Int/Topo IB signature motif; other site 1246995011667 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1246995011668 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1246995011669 TAP-like protein; Region: Abhydrolase_4; pfam08386 1246995011670 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1246995011671 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1246995011672 MarR family; Region: MarR; pfam01047 1246995011673 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1246995011674 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1246995011675 Coenzyme A binding pocket [chemical binding]; other site 1246995011676 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1246995011677 putative catalytic site [active] 1246995011678 putative metal binding site [ion binding]; other site 1246995011679 putative catalytic site [active] 1246995011680 putative phosphate binding site [ion binding]; other site 1246995011681 putative phosphate binding site [ion binding]; other site 1246995011682 putative metal binding site [ion binding]; other site 1246995011683 hypothetical protein; Provisional; Region: PRK02487 1246995011684 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 1246995011685 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1246995011686 G1 box; other site 1246995011687 GTP/Mg2+ binding site [chemical binding]; other site 1246995011688 G2 box; other site 1246995011689 Switch I region; other site 1246995011690 G3 box; other site 1246995011691 Switch II region; other site 1246995011692 G4 box; other site 1246995011693 G5 box; other site 1246995011694 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 1246995011695 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 1246995011696 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 1246995011697 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1246995011698 active site 1246995011699 metal binding site [ion binding]; metal-binding site 1246995011700 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1246995011701 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1246995011702 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 1246995011703 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1246995011704 Sulfatase; Region: Sulfatase; cl17466 1246995011705 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094 1246995011706 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1246995011707 TAP-like protein; Region: Abhydrolase_4; pfam08386 1246995011708 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1246995011709 Histidine kinase; Region: HisKA_3; pfam07730 1246995011710 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995011711 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995011712 active site 1246995011713 phosphorylation site [posttranslational modification] 1246995011714 intermolecular recognition site; other site 1246995011715 dimerization interface [polypeptide binding]; other site 1246995011716 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995011717 DNA binding residues [nucleotide binding] 1246995011718 dimerization interface [polypeptide binding]; other site 1246995011719 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1246995011720 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1246995011721 Histidine kinase; Region: HisKA_3; pfam07730 1246995011722 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995011723 ATP binding site [chemical binding]; other site 1246995011724 Mg2+ binding site [ion binding]; other site 1246995011725 G-X-G motif; other site 1246995011726 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995011727 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995011728 active site 1246995011729 phosphorylation site [posttranslational modification] 1246995011730 intermolecular recognition site; other site 1246995011731 dimerization interface [polypeptide binding]; other site 1246995011732 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995011733 DNA binding residues [nucleotide binding] 1246995011734 dimerization interface [polypeptide binding]; other site 1246995011735 EcsC protein family; Region: EcsC; pfam12787 1246995011736 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1246995011737 S-adenosylmethionine binding site [chemical binding]; other site 1246995011738 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 1246995011739 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1246995011740 hypothetical protein; Provisional; Region: PRK08244 1246995011741 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1246995011742 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1246995011743 Erythromycin esterase; Region: Erythro_esteras; pfam05139 1246995011744 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1246995011745 DNA binding residues [nucleotide binding] 1246995011746 Second Helix-Turn-Helix DNA binding domain of the regulatory protein TioE; Region: HTH_TioE_rpt2; cd04773 1246995011747 DNA binding residues [nucleotide binding] 1246995011748 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1246995011749 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1246995011750 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1246995011751 Dienelactone hydrolase family; Region: DLH; pfam01738 1246995011752 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1246995011753 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1246995011754 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 1246995011755 putative dimerization interface [polypeptide binding]; other site 1246995011756 Class I aldolases; Region: Aldolase_Class_I; cl17187 1246995011757 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1246995011758 catalytic residue [active] 1246995011759 Beta-lactamase; Region: Beta-lactamase; pfam00144 1246995011760 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1246995011761 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1246995011762 metal binding site [ion binding]; metal-binding site 1246995011763 active site 1246995011764 I-site; other site 1246995011765 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1246995011766 Uncharacterized conserved protein [Function unknown]; Region: COG3287 1246995011767 FIST N domain; Region: FIST; smart00897 1246995011768 FIST C domain; Region: FIST_C; pfam10442 1246995011769 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1246995011770 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995011771 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995011772 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1246995011773 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1246995011774 DNA binding site [nucleotide binding] 1246995011775 domain linker motif; other site 1246995011776 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1246995011777 ligand binding site [chemical binding]; other site 1246995011778 dimerization interface [polypeptide binding]; other site 1246995011779 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1246995011780 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1246995011781 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995011782 dimer interface [polypeptide binding]; other site 1246995011783 conserved gate region; other site 1246995011784 putative PBP binding loops; other site 1246995011785 ABC-ATPase subunit interface; other site 1246995011786 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1246995011787 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995011788 dimer interface [polypeptide binding]; other site 1246995011789 conserved gate region; other site 1246995011790 putative PBP binding loops; other site 1246995011791 ABC-ATPase subunit interface; other site 1246995011792 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 1246995011793 Putative glucoamylase; Region: Glycoamylase; pfam10091 1246995011794 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229 1246995011795 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995011796 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995011797 active site 1246995011798 phosphorylation site [posttranslational modification] 1246995011799 intermolecular recognition site; other site 1246995011800 dimerization interface [polypeptide binding]; other site 1246995011801 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995011802 DNA binding residues [nucleotide binding] 1246995011803 dimerization interface [polypeptide binding]; other site 1246995011804 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1246995011805 Histidine kinase; Region: HisKA_3; pfam07730 1246995011806 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1246995011807 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 1246995011808 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 1246995011809 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 1246995011810 active site 1246995011811 catalytic residues [active] 1246995011812 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 1246995011813 Broad specificity phosphatase PhoE and related phosphatases [General function prediction only]; Region: phoE; COG0406 1246995011814 Phosphotransferase enzyme family; Region: APH; pfam01636 1246995011815 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1246995011816 substrate binding site [chemical binding]; other site 1246995011817 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1246995011818 putative DNA binding site [nucleotide binding]; other site 1246995011819 putative Zn2+ binding site [ion binding]; other site 1246995011820 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1246995011821 putative hydrophobic ligand binding site [chemical binding]; other site 1246995011822 short chain dehydrogenase; Validated; Region: PRK05855 1246995011823 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1246995011824 PAS domain; Region: PAS; smart00091 1246995011825 PAS fold; Region: PAS_4; pfam08448 1246995011826 putative active site [active] 1246995011827 heme pocket [chemical binding]; other site 1246995011828 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1246995011829 dimer interface [polypeptide binding]; other site 1246995011830 phosphorylation site [posttranslational modification] 1246995011831 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995011832 ATP binding site [chemical binding]; other site 1246995011833 Mg2+ binding site [ion binding]; other site 1246995011834 G-X-G motif; other site 1246995011835 Response regulator receiver domain; Region: Response_reg; pfam00072 1246995011836 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995011837 active site 1246995011838 phosphorylation site [posttranslational modification] 1246995011839 intermolecular recognition site; other site 1246995011840 dimerization interface [polypeptide binding]; other site 1246995011841 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1246995011842 putative binding surface; other site 1246995011843 active site 1246995011844 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 1246995011845 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 1246995011846 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1246995011847 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 1246995011848 Ligand binding site; other site 1246995011849 Putative Catalytic site; other site 1246995011850 DXD motif; other site 1246995011851 apolipoprotein N-acyltransferase; Region: lnt; TIGR00546 1246995011852 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1246995011853 putative active site [active] 1246995011854 catalytic triad [active] 1246995011855 putative dimer interface [polypeptide binding]; other site 1246995011856 MutL protein; Region: MutL; pfam13941 1246995011857 Thioesterase superfamily; Region: 4HBT; pfam03061 1246995011858 active site 2 [active] 1246995011859 B12 binding domain; Region: B12-binding; pfam02310 1246995011860 B12 binding site [chemical binding]; other site 1246995011861 D-Lysine 5,6-aminomutase alpha subunit; Region: Lys-AminoMut_A; pfam09043 1246995011862 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1246995011863 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1246995011864 active site 1246995011865 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 1246995011866 CsbD-like; Region: CsbD; cl17424 1246995011867 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1246995011868 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1246995011869 S-adenosylmethionine binding site [chemical binding]; other site 1246995011870 Phosphotransferase enzyme family; Region: APH; pfam01636 1246995011871 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1246995011872 active site 1246995011873 ATP binding site [chemical binding]; other site 1246995011874 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 1246995011875 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995011876 active site 1246995011877 phosphorylation site [posttranslational modification] 1246995011878 intermolecular recognition site; other site 1246995011879 dimerization interface [polypeptide binding]; other site 1246995011880 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1246995011881 DNA binding site [nucleotide binding] 1246995011882 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1246995011883 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1246995011884 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1246995011885 putative DNA binding site [nucleotide binding]; other site 1246995011886 putative Zn2+ binding site [ion binding]; other site 1246995011887 AsnC family; Region: AsnC_trans_reg; pfam01037 1246995011888 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1246995011889 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1246995011890 active site 1246995011891 5'-3' exonuclease; Region: 53EXOc; smart00475 1246995011892 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1246995011893 active site 1246995011894 metal binding site 1 [ion binding]; metal-binding site 1246995011895 putative 5' ssDNA interaction site; other site 1246995011896 metal binding site 3; metal-binding site 1246995011897 metal binding site 2 [ion binding]; metal-binding site 1246995011898 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1246995011899 putative DNA binding site [nucleotide binding]; other site 1246995011900 putative metal binding site [ion binding]; other site 1246995011901 PAS domain S-box; Region: sensory_box; TIGR00229 1246995011902 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1246995011903 putative active site [active] 1246995011904 heme pocket [chemical binding]; other site 1246995011905 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1246995011906 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1246995011907 metal binding site [ion binding]; metal-binding site 1246995011908 active site 1246995011909 I-site; other site 1246995011910 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1246995011911 Protein of unknown function (DUF419); Region: DUF419; cl15265 1246995011912 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995011913 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995011914 Predicted esterase [General function prediction only]; Region: COG0400 1246995011915 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 1246995011916 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1246995011917 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1246995011918 PAS domain S-box; Region: sensory_box; TIGR00229 1246995011919 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1246995011920 putative active site [active] 1246995011921 heme pocket [chemical binding]; other site 1246995011922 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1246995011923 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1246995011924 metal binding site [ion binding]; metal-binding site 1246995011925 active site 1246995011926 I-site; other site 1246995011927 Domain of unknown function (DUF1772); Region: DUF1772; pfam08592 1246995011928 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 1246995011929 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 1246995011930 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 1246995011931 active site 1246995011932 dimer interface [polypeptide binding]; other site 1246995011933 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1246995011934 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995011935 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995011936 active site 1246995011937 phosphorylation site [posttranslational modification] 1246995011938 intermolecular recognition site; other site 1246995011939 dimerization interface [polypeptide binding]; other site 1246995011940 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995011941 DNA binding residues [nucleotide binding] 1246995011942 dimerization interface [polypeptide binding]; other site 1246995011943 BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473 1246995011944 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1246995011945 Histidine kinase; Region: HisKA_3; pfam07730 1246995011946 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 1246995011947 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1246995011948 Walker A/P-loop; other site 1246995011949 ATP binding site [chemical binding]; other site 1246995011950 Q-loop/lid; other site 1246995011951 ABC transporter signature motif; other site 1246995011952 Walker B; other site 1246995011953 D-loop; other site 1246995011954 H-loop/switch region; other site 1246995011955 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 1246995011956 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 1246995011957 Putative cyclase; Region: Cyclase; cl00814 1246995011958 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1246995011959 active site 1246995011960 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1246995011961 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1246995011962 DNA binding residues [nucleotide binding] 1246995011963 Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699 1246995011964 marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788 1246995011965 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1246995011966 metal ion-dependent adhesion site (MIDAS); other site 1246995011967 TAP-like protein; Region: Abhydrolase_4; pfam08386 1246995011968 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1246995011969 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1246995011970 putative sugar binding sites [chemical binding]; other site 1246995011971 Q-X-W motif; other site 1246995011972 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 1246995011973 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1246995011974 dimanganese center [ion binding]; other site 1246995011975 Predicted membrane protein (DUF2243); Region: DUF2243; cl01783 1246995011976 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 1246995011977 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1246995011978 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 1246995011979 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1246995011980 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995011981 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1246995011982 active site 1246995011983 phosphorylation site [posttranslational modification] 1246995011984 intermolecular recognition site; other site 1246995011985 dimerization interface [polypeptide binding]; other site 1246995011986 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995011987 DNA binding residues [nucleotide binding] 1246995011988 dimerization interface [polypeptide binding]; other site 1246995011989 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1246995011990 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995011991 ATP binding site [chemical binding]; other site 1246995011992 Mg2+ binding site [ion binding]; other site 1246995011993 G-X-G motif; other site 1246995011994 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1246995011995 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1246995011996 active site 1246995011997 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1246995011998 S-adenosylmethionine binding site [chemical binding]; other site 1246995011999 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1246995012000 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1246995012001 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1246995012002 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995012003 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1246995012004 Walker A/P-loop; other site 1246995012005 ATP binding site [chemical binding]; other site 1246995012006 Q-loop/lid; other site 1246995012007 ABC transporter signature motif; other site 1246995012008 Walker B; other site 1246995012009 D-loop; other site 1246995012010 H-loop/switch region; other site 1246995012011 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1246995012012 Erythromycin esterase; Region: Erythro_esteras; pfam05139 1246995012013 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1246995012014 salt bridge; other site 1246995012015 non-specific DNA binding site [nucleotide binding]; other site 1246995012016 sequence-specific DNA binding site [nucleotide binding]; other site 1246995012017 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1246995012018 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1246995012019 active site 1246995012020 catalytic tetrad [active] 1246995012021 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1246995012022 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1246995012023 Transmembrane secretion effector; Region: MFS_3; pfam05977 1246995012024 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1246995012025 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1246995012026 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1246995012027 putative sugar binding sites [chemical binding]; other site 1246995012028 Q-X-W motif; other site 1246995012029 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179 1246995012030 active site 1246995012031 metal binding site [ion binding]; metal-binding site 1246995012032 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 1246995012033 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1246995012034 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 1246995012035 Coenzyme A binding pocket [chemical binding]; other site 1246995012036 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1246995012037 Coenzyme A binding pocket [chemical binding]; other site 1246995012038 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1246995012039 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995012040 short chain dehydrogenase; Provisional; Region: PRK07454 1246995012041 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995012042 NAD(P) binding site [chemical binding]; other site 1246995012043 active site 1246995012044 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995012045 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995012046 WHG domain; Region: WHG; pfam13305 1246995012047 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1246995012048 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1246995012049 putative acyl-acceptor binding pocket; other site 1246995012050 probable non-F420 flavinoid oxidoreductase; Region: flavin_revert; TIGR03885 1246995012051 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1246995012052 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 1246995012053 active site 1246995012054 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1246995012055 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995012056 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1246995012057 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995012058 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995012059 active site 1246995012060 phosphorylation site [posttranslational modification] 1246995012061 intermolecular recognition site; other site 1246995012062 dimerization interface [polypeptide binding]; other site 1246995012063 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995012064 DNA binding residues [nucleotide binding] 1246995012065 dimerization interface [polypeptide binding]; other site 1246995012066 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1246995012067 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1246995012068 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1246995012069 Histidine kinase; Region: HisKA_3; pfam07730 1246995012070 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1246995012071 hypothetical protein; Provisional; Region: PRK07877 1246995012072 hypothetical protein; Provisional; Region: PRK07877 1246995012073 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1246995012074 substrate binding site [chemical binding]; other site 1246995012075 MarR family; Region: MarR_2; pfam12802 1246995012076 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1246995012077 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 1246995012078 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1246995012079 active site 1246995012080 ATP binding site [chemical binding]; other site 1246995012081 substrate binding site [chemical binding]; other site 1246995012082 activation loop (A-loop); other site 1246995012083 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1246995012084 hydrophobic ligand binding site; other site 1246995012085 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 1246995012086 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 1246995012087 metal binding site [ion binding]; metal-binding site 1246995012088 dimer interface [polypeptide binding]; other site 1246995012089 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1246995012090 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1246995012091 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1246995012092 dimerization interface [polypeptide binding]; other site 1246995012093 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1246995012094 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1246995012095 2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745 1246995012096 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1246995012097 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1246995012098 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1246995012099 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1246995012100 active site residue [active] 1246995012101 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1246995012102 active site residue [active] 1246995012103 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1246995012104 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995012105 dimer interface [polypeptide binding]; other site 1246995012106 conserved gate region; other site 1246995012107 putative PBP binding loops; other site 1246995012108 ABC-ATPase subunit interface; other site 1246995012109 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1246995012110 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1246995012111 Walker A/P-loop; other site 1246995012112 ATP binding site [chemical binding]; other site 1246995012113 Q-loop/lid; other site 1246995012114 ABC transporter signature motif; other site 1246995012115 Walker B; other site 1246995012116 D-loop; other site 1246995012117 H-loop/switch region; other site 1246995012118 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1246995012119 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1246995012120 substrate binding pocket [chemical binding]; other site 1246995012121 membrane-bound complex binding site; other site 1246995012122 hinge residues; other site 1246995012123 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1246995012124 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1246995012125 dimer interface [polypeptide binding]; other site 1246995012126 active site 1246995012127 non-prolyl cis peptide bond; other site 1246995012128 insertion regions; other site 1246995012129 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1246995012130 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1246995012131 substrate binding pocket [chemical binding]; other site 1246995012132 membrane-bound complex binding site; other site 1246995012133 hinge residues; other site 1246995012134 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1246995012135 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1246995012136 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1246995012137 FAD binding domain; Region: FAD_binding_4; pfam01565 1246995012138 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1246995012139 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1246995012140 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1246995012141 WHG domain; Region: WHG; pfam13305 1246995012142 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1246995012143 homotrimer interaction site [polypeptide binding]; other site 1246995012144 putative active site [active] 1246995012145 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1246995012146 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 1246995012147 active site 1246995012148 dimer interface [polypeptide binding]; other site 1246995012149 non-prolyl cis peptide bond; other site 1246995012150 insertion regions; other site 1246995012151 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1246995012152 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1246995012153 substrate binding pocket [chemical binding]; other site 1246995012154 membrane-bound complex binding site; other site 1246995012155 hinge residues; other site 1246995012156 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1246995012157 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995012158 dimer interface [polypeptide binding]; other site 1246995012159 conserved gate region; other site 1246995012160 putative PBP binding loops; other site 1246995012161 ABC-ATPase subunit interface; other site 1246995012162 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1246995012163 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995012164 Walker A/P-loop; other site 1246995012165 ATP binding site [chemical binding]; other site 1246995012166 Q-loop/lid; other site 1246995012167 ABC transporter signature motif; other site 1246995012168 Walker B; other site 1246995012169 D-loop; other site 1246995012170 H-loop/switch region; other site 1246995012171 Predicted membrane protein [Function unknown]; Region: COG4682 1246995012172 yiaA/B two helix domain; Region: YiaAB; pfam05360 1246995012173 yiaA/B two helix domain; Region: YiaAB; pfam05360 1246995012174 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 1246995012175 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1246995012176 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 1246995012177 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1246995012178 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1246995012179 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1246995012180 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 1246995012181 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1246995012182 active site 1246995012183 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1246995012184 non-prolyl cis peptide bond; other site 1246995012185 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1246995012186 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1246995012187 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1246995012188 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1246995012189 Walker A/P-loop; other site 1246995012190 ATP binding site [chemical binding]; other site 1246995012191 Q-loop/lid; other site 1246995012192 ABC transporter signature motif; other site 1246995012193 Walker B; other site 1246995012194 D-loop; other site 1246995012195 H-loop/switch region; other site 1246995012196 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1246995012197 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1246995012198 Walker A/P-loop; other site 1246995012199 ATP binding site [chemical binding]; other site 1246995012200 Q-loop/lid; other site 1246995012201 ABC transporter signature motif; other site 1246995012202 Walker B; other site 1246995012203 D-loop; other site 1246995012204 H-loop/switch region; other site 1246995012205 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1246995012206 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1246995012207 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995012208 dimer interface [polypeptide binding]; other site 1246995012209 conserved gate region; other site 1246995012210 ABC-ATPase subunit interface; other site 1246995012211 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1246995012212 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995012213 dimer interface [polypeptide binding]; other site 1246995012214 conserved gate region; other site 1246995012215 putative PBP binding loops; other site 1246995012216 ABC-ATPase subunit interface; other site 1246995012217 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1246995012218 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 1246995012219 Phosphotransferase enzyme family; Region: APH; pfam01636 1246995012220 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1246995012221 substrate binding site [chemical binding]; other site 1246995012222 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1246995012223 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1246995012224 Walker A/P-loop; other site 1246995012225 ATP binding site [chemical binding]; other site 1246995012226 Q-loop/lid; other site 1246995012227 ABC transporter signature motif; other site 1246995012228 Walker B; other site 1246995012229 D-loop; other site 1246995012230 H-loop/switch region; other site 1246995012231 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1246995012232 FtsX-like permease family; Region: FtsX; pfam02687 1246995012233 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 1246995012234 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1246995012235 Ligand Binding Site [chemical binding]; other site 1246995012236 amino acid transporter; Region: 2A0306; TIGR00909 1246995012237 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1246995012238 inhibitor site; inhibition site 1246995012239 active site 1246995012240 dimer interface [polypeptide binding]; other site 1246995012241 catalytic residue [active] 1246995012242 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 1246995012243 NmrA-like family; Region: NmrA; pfam05368 1246995012244 NADP binding site [chemical binding]; other site 1246995012245 active site 1246995012246 regulatory binding site [polypeptide binding]; other site 1246995012247 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995012248 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995012249 putative alpha-glucosidase; Provisional; Region: PRK10658 1246995012250 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1246995012251 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 1246995012252 active site 1246995012253 homotrimer interface [polypeptide binding]; other site 1246995012254 catalytic site [active] 1246995012255 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 1246995012256 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1246995012257 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995012258 dimer interface [polypeptide binding]; other site 1246995012259 conserved gate region; other site 1246995012260 putative PBP binding loops; other site 1246995012261 ABC-ATPase subunit interface; other site 1246995012262 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995012263 dimer interface [polypeptide binding]; other site 1246995012264 conserved gate region; other site 1246995012265 putative PBP binding loops; other site 1246995012266 ABC-ATPase subunit interface; other site 1246995012267 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1246995012268 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1246995012269 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK11234 1246995012270 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 1246995012271 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1246995012272 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1246995012273 DNA binding site [nucleotide binding] 1246995012274 domain linker motif; other site 1246995012275 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1246995012276 dimerization interface [polypeptide binding]; other site 1246995012277 ligand binding site [chemical binding]; other site 1246995012278 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1246995012279 S-adenosylmethionine binding site [chemical binding]; other site 1246995012280 Cellulose binding domain; Region: CBM_2; cl17741 1246995012281 HEAT repeats; Region: HEAT_2; pfam13646 1246995012282 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1246995012283 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1246995012284 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1246995012285 homodimer interface [polypeptide binding]; other site 1246995012286 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1246995012287 active site 1246995012288 TDP-binding site; other site 1246995012289 acceptor substrate-binding pocket; other site 1246995012290 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1246995012291 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1246995012292 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1246995012293 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 1246995012294 active site 1246995012295 intersubunit interface [polypeptide binding]; other site 1246995012296 zinc binding site [ion binding]; other site 1246995012297 Na+ binding site [ion binding]; other site 1246995012298 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1246995012299 putative substrate binding site [chemical binding]; other site 1246995012300 putative ATP binding site [chemical binding]; other site 1246995012301 TM1410 hypothetical-related protein; Region: DUF297; pfam03537 1246995012302 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1246995012303 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1246995012304 substrate binding site [chemical binding]; other site 1246995012305 ATP binding site [chemical binding]; other site 1246995012306 AAA domain; Region: AAA_33; pfam13671 1246995012307 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 1246995012308 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1246995012309 S-adenosylmethionine binding site [chemical binding]; other site 1246995012310 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 1246995012311 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1246995012312 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1246995012313 Coenzyme A binding pocket [chemical binding]; other site 1246995012314 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1246995012315 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1246995012316 non-specific DNA binding site [nucleotide binding]; other site 1246995012317 salt bridge; other site 1246995012318 sequence-specific DNA binding site [nucleotide binding]; other site 1246995012319 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1246995012320 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995012321 dimer interface [polypeptide binding]; other site 1246995012322 conserved gate region; other site 1246995012323 putative PBP binding loops; other site 1246995012324 ABC-ATPase subunit interface; other site 1246995012325 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1246995012326 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995012327 dimer interface [polypeptide binding]; other site 1246995012328 conserved gate region; other site 1246995012329 putative PBP binding loops; other site 1246995012330 ABC-ATPase subunit interface; other site 1246995012331 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1246995012332 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1246995012333 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1246995012334 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1246995012335 dimer interface [polypeptide binding]; other site 1246995012336 active site 1246995012337 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1246995012338 dimer interface [polypeptide binding]; other site 1246995012339 active site 1246995012340 alpha-galactosidase; Provisional; Region: PRK15076 1246995012341 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 1246995012342 NAD binding site [chemical binding]; other site 1246995012343 sugar binding site [chemical binding]; other site 1246995012344 divalent metal binding site [ion binding]; other site 1246995012345 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 1246995012346 dimer interface [polypeptide binding]; other site 1246995012347 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1246995012348 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1246995012349 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1246995012350 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 1246995012351 Predicted transcriptional regulators [Transcription]; Region: COG1695 1246995012352 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1246995012353 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995012354 oxidoreductase; Provisional; Region: PRK06196 1246995012355 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1246995012356 putative NAD(P) binding site [chemical binding]; other site 1246995012357 active site 1246995012358 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1246995012359 active site 1246995012360 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1246995012361 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1246995012362 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1246995012363 FtsH Extracellular; Region: FtsH_ext; pfam06480 1246995012364 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1246995012365 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1246995012366 Walker A motif; other site 1246995012367 ATP binding site [chemical binding]; other site 1246995012368 Walker B motif; other site 1246995012369 arginine finger; other site 1246995012370 Peptidase family M41; Region: Peptidase_M41; pfam01434 1246995012371 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1246995012372 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1246995012373 DNA binding residues [nucleotide binding] 1246995012374 dimer interface [polypeptide binding]; other site 1246995012375 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1246995012376 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1246995012377 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 1246995012378 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995012379 Walker A/P-loop; other site 1246995012380 ATP binding site [chemical binding]; other site 1246995012381 Q-loop/lid; other site 1246995012382 ABC transporter signature motif; other site 1246995012383 Walker B; other site 1246995012384 D-loop; other site 1246995012385 H-loop/switch region; other site 1246995012386 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1246995012387 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1246995012388 substrate binding pocket [chemical binding]; other site 1246995012389 chain length determination region; other site 1246995012390 substrate-Mg2+ binding site; other site 1246995012391 catalytic residues [active] 1246995012392 aspartate-rich region 1; other site 1246995012393 active site lid residues [active] 1246995012394 aspartate-rich region 2; other site 1246995012395 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 1246995012396 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 1246995012397 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1246995012398 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1246995012399 TatD related DNase; Region: TatD_DNase; pfam01026 1246995012400 active site 1246995012401 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1246995012402 UbiA prenyltransferase family; Region: UbiA; pfam01040 1246995012403 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 1246995012404 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; pfam07994 1246995012405 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1246995012406 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1246995012407 active site 1246995012408 ATP binding site [chemical binding]; other site 1246995012409 substrate binding site [chemical binding]; other site 1246995012410 activation loop (A-loop); other site 1246995012411 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 1246995012412 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1246995012413 hypothetical protein; Provisional; Region: PRK07236 1246995012414 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 1246995012415 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995012416 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 1246995012417 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1246995012418 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1246995012419 active site 1246995012420 Right handed beta helix region; Region: Beta_helix; pfam13229 1246995012421 Right handed beta helix region; Region: Beta_helix; pfam13229 1246995012422 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1246995012423 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1246995012424 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1246995012425 enolase; Provisional; Region: eno; PRK00077 1246995012426 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1246995012427 dimer interface [polypeptide binding]; other site 1246995012428 metal binding site [ion binding]; metal-binding site 1246995012429 substrate binding pocket [chemical binding]; other site 1246995012430 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1246995012431 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1246995012432 DNA binding residues [nucleotide binding] 1246995012433 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1246995012434 catalytic triad [active] 1246995012435 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1246995012436 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1246995012437 dimer interface [polypeptide binding]; other site 1246995012438 putative functional site; other site 1246995012439 putative MPT binding site; other site 1246995012440 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1246995012441 S-adenosylmethionine binding site [chemical binding]; other site 1246995012442 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1246995012443 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1246995012444 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1246995012445 putative catalytic site [active] 1246995012446 putative metal binding site [ion binding]; other site 1246995012447 putative phosphate binding site [ion binding]; other site 1246995012448 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1246995012449 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1246995012450 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1246995012451 dimerization interface [polypeptide binding]; other site 1246995012452 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1246995012453 dimer interface [polypeptide binding]; other site 1246995012454 putative CheW interface [polypeptide binding]; other site 1246995012455 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1246995012456 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1246995012457 metal binding site [ion binding]; metal-binding site 1246995012458 active site 1246995012459 I-site; other site 1246995012460 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1246995012461 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 1246995012462 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1246995012463 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1246995012464 catalytic loop [active] 1246995012465 iron binding site [ion binding]; other site 1246995012466 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1246995012467 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1246995012468 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1246995012469 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1246995012470 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 1246995012471 Phosphotransferase enzyme family; Region: APH; pfam01636 1246995012472 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1246995012473 active site 1246995012474 substrate binding site [chemical binding]; other site 1246995012475 ATP binding site [chemical binding]; other site 1246995012476 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1246995012477 substrate binding site [chemical binding]; other site 1246995012478 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1246995012479 amino acid transporter; Region: 2A0306; TIGR00909 1246995012480 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1246995012481 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995012482 active site 1246995012483 phosphorylation site [posttranslational modification] 1246995012484 intermolecular recognition site; other site 1246995012485 dimerization interface [polypeptide binding]; other site 1246995012486 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1246995012487 DNA binding site [nucleotide binding] 1246995012488 NAD-dependent deacetylase; Provisional; Region: PRK00481 1246995012489 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 1246995012490 NAD+ binding site [chemical binding]; other site 1246995012491 substrate binding site [chemical binding]; other site 1246995012492 Zn binding site [ion binding]; other site 1246995012493 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1246995012494 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1246995012495 Predicted transcriptional regulators [Transcription]; Region: COG1695 1246995012496 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1246995012497 Protein of unknown function (DUF4240); Region: DUF4240; pfam14024 1246995012498 RNA polymerase sigma-70 factor, TIGR02960 family; Region: SigX5 1246995012499 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995012500 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1246995012501 DNA binding residues [nucleotide binding] 1246995012502 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1246995012503 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1246995012504 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1246995012505 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1246995012506 dimerization interface [polypeptide binding]; other site 1246995012507 putative DNA binding site [nucleotide binding]; other site 1246995012508 putative Zn2+ binding site [ion binding]; other site 1246995012509 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1246995012510 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1246995012511 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1246995012512 nucleophile elbow; other site 1246995012513 putative phosphoketolase; Provisional; Region: PRK05261 1246995012514 XFP N-terminal domain; Region: XFP_N; pfam09364 1246995012515 XFP C-terminal domain; Region: XFP_C; pfam09363 1246995012516 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1246995012517 active site 1246995012518 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1246995012519 catalytic tetrad [active] 1246995012520 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995012521 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1246995012522 NAD(P) binding site [chemical binding]; other site 1246995012523 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1246995012524 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 1246995012525 active site 1246995012526 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1246995012527 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1246995012528 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 1246995012529 putative substrate binding pocket [chemical binding]; other site 1246995012530 putative dimerization interface [polypeptide binding]; other site 1246995012531 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1246995012532 sequence-specific DNA binding site [nucleotide binding]; other site 1246995012533 salt bridge; other site 1246995012534 Cupin domain; Region: Cupin_2; pfam07883 1246995012535 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1246995012536 putative substrate translocation pore; other site 1246995012537 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1246995012538 active site 1246995012539 ATP binding site [chemical binding]; other site 1246995012540 substrate binding site [chemical binding]; other site 1246995012541 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1246995012542 Domain of unknown function (DUF4267); Region: DUF4267; pfam14087 1246995012543 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1246995012544 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1246995012545 Cinnamyl alcohol dehydrogenases (CAD) and related proteins; Region: CAD; cd08245 1246995012546 NAD binding site [chemical binding]; other site 1246995012547 substrate binding site [chemical binding]; other site 1246995012548 catalytic Zn binding site [ion binding]; other site 1246995012549 structural Zn binding site [ion binding]; other site 1246995012550 tetramer interface [polypeptide binding]; other site 1246995012551 NHL repeat; Region: NHL; pfam01436 1246995012552 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1246995012553 Interdomain contacts; other site 1246995012554 Cytokine receptor motif; other site 1246995012555 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1246995012556 Interdomain contacts; other site 1246995012557 Cytokine receptor motif; other site 1246995012558 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1246995012559 Interdomain contacts; other site 1246995012560 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1246995012561 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1246995012562 Interdomain contacts; other site 1246995012563 Cytokine receptor motif; other site 1246995012564 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1246995012565 Interdomain contacts; other site 1246995012566 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1246995012567 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1246995012568 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1246995012569 Interdomain contacts; other site 1246995012570 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1246995012571 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1246995012572 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1246995012573 Interdomain contacts; other site 1246995012574 Cytokine receptor motif; other site 1246995012575 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1246995012576 Interdomain contacts; other site 1246995012577 Cytokine receptor motif; other site 1246995012578 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1246995012579 Interdomain contacts; other site 1246995012580 Cytokine receptor motif; other site 1246995012581 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1246995012582 Interdomain contacts; other site 1246995012583 Cytokine receptor motif; other site 1246995012584 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1246995012585 Interdomain contacts; other site 1246995012586 Cytokine receptor motif; other site 1246995012587 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1246995012588 Interdomain contacts; other site 1246995012589 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1246995012590 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1246995012591 Interdomain contacts; other site 1246995012592 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1246995012593 Interdomain contacts; other site 1246995012594 Cytokine receptor motif; other site 1246995012595 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1246995012596 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1246995012597 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1246995012598 Interdomain contacts; other site 1246995012599 Cytokine receptor motif; other site 1246995012600 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1246995012601 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1246995012602 Interdomain contacts; other site 1246995012603 Cytokine receptor motif; other site 1246995012604 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1246995012605 Interdomain contacts; other site 1246995012606 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1246995012607 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1246995012608 Carbohydrate Binding Module family 35 (CBM35), pectate lyase-like; appended mainly to enzymes that bind mannan (Man), xylan, glucuronic acid (GlcA) and possibly glucans; Region: CBM35_pectate_lyase-like; cd04082 1246995012609 Ca binding site [ion binding]; other site 1246995012610 Ca binding site (active) [ion binding]; other site 1246995012611 ligand binding site [chemical binding]; other site 1246995012612 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1246995012613 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 1246995012614 hypothetical protein; Provisional; Region: PRK07236 1246995012615 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1246995012616 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995012617 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995012618 Phosphotransferase enzyme family; Region: APH; pfam01636 1246995012619 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1246995012620 active site 1246995012621 ATP binding site [chemical binding]; other site 1246995012622 substrate binding site [chemical binding]; other site 1246995012623 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1246995012624 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1246995012625 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1246995012626 anti sigma factor interaction site; other site 1246995012627 regulatory phosphorylation site [posttranslational modification]; other site 1246995012628 CAAX protease self-immunity; Region: Abi; pfam02517 1246995012629 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1246995012630 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995012631 NAD(P) binding site [chemical binding]; other site 1246995012632 active site 1246995012633 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1246995012634 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1246995012635 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1246995012636 MOSC domain; Region: MOSC; pfam03473 1246995012637 3-alpha domain; Region: 3-alpha; pfam03475 1246995012638 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1246995012639 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 1246995012640 FAD binding pocket [chemical binding]; other site 1246995012641 FAD binding motif [chemical binding]; other site 1246995012642 phosphate binding motif [ion binding]; other site 1246995012643 beta-alpha-beta structure motif; other site 1246995012644 NAD binding pocket [chemical binding]; other site 1246995012645 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1246995012646 catalytic loop [active] 1246995012647 iron binding site [ion binding]; other site 1246995012648 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995012649 short chain dehydrogenase; Provisional; Region: PRK07041 1246995012650 NAD(P) binding site [chemical binding]; other site 1246995012651 active site 1246995012652 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1246995012653 Protein of unknown function (DUF1440); Region: DUF1440; cl01380 1246995012654 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1246995012655 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995012656 NAD(P) binding site [chemical binding]; other site 1246995012657 active site 1246995012658 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1246995012659 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1246995012660 AAA ATPase domain; Region: AAA_16; pfam13191 1246995012661 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995012662 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995012663 DNA binding residues [nucleotide binding] 1246995012664 dimerization interface [polypeptide binding]; other site 1246995012665 Epoxide hydrolase N terminus; Region: EHN; pfam06441 1246995012666 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1246995012667 Epoxide hydrolase N terminus; Region: EHN; pfam06441 1246995012668 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1246995012669 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1246995012670 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1246995012671 histidinol phosphate phosphatase, HisJ family; Region: hisJ_fam; TIGR01856 1246995012672 active site 1246995012673 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 1246995012674 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1246995012675 SnoaL-like domain; Region: SnoaL_2; pfam12680 1246995012676 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1246995012677 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1246995012678 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1246995012679 active site 1246995012680 metal binding site [ion binding]; metal-binding site 1246995012681 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995012682 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995012683 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1246995012684 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1246995012685 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 1246995012686 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1246995012687 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1246995012688 MarR family; Region: MarR_2; pfam12802 1246995012689 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 1246995012690 putative FMN binding site [chemical binding]; other site 1246995012691 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 1246995012692 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1246995012693 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1246995012694 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1246995012695 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1246995012696 Predicted transcriptional regulators [Transcription]; Region: COG1695 1246995012697 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1246995012698 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 1246995012699 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1246995012700 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1246995012701 active site 1246995012702 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 1246995012703 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1246995012704 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1246995012705 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1246995012706 short chain dehydrogenase; Provisional; Region: PRK06197 1246995012707 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1246995012708 putative NAD(P) binding site [chemical binding]; other site 1246995012709 active site 1246995012710 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 1246995012711 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1246995012712 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1246995012713 motif II; other site 1246995012714 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1246995012715 active site 1246995012716 catalytic residues [active] 1246995012717 GAF domain; Region: GAF; cl17456 1246995012718 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995012719 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995012720 dimerization interface [polypeptide binding]; other site 1246995012721 DNA binding residues [nucleotide binding] 1246995012722 Fructose-bisphosphate aldolase class-II; Region: F_bP_aldolase; pfam01116 1246995012723 active site 1246995012724 intersubunit interface [polypeptide binding]; other site 1246995012725 zinc binding site [ion binding]; other site 1246995012726 Na+ binding site [ion binding]; other site 1246995012727 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1246995012728 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1246995012729 motif II; other site 1246995012730 DAK2 domain; Region: Dak2; cl03685 1246995012731 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 1246995012732 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 1246995012733 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 1246995012734 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1246995012735 dimerization interface [polypeptide binding]; other site 1246995012736 putative DNA binding site [nucleotide binding]; other site 1246995012737 putative Zn2+ binding site [ion binding]; other site 1246995012738 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 1246995012739 putative hydrophobic ligand binding site [chemical binding]; other site 1246995012740 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 1246995012741 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 1246995012742 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 1246995012743 putative DNA binding site [nucleotide binding]; other site 1246995012744 putative homodimer interface [polypeptide binding]; other site 1246995012745 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1246995012746 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1246995012747 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1246995012748 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1246995012749 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 1246995012750 putative active site [active] 1246995012751 catalytic site [active] 1246995012752 Catalytic domain, repeat 2, of vertebrate phospholipases, PLD1 and PLD2, and similar proteins; Region: PLDc_vPLD1_2_like_2; cd09105 1246995012753 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1246995012754 putative active site [active] 1246995012755 putative active site [active] 1246995012756 catalytic site [active] 1246995012757 catalytic site [active] 1246995012758 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1246995012759 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1246995012760 active site 1246995012761 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995012762 short chain dehydrogenase; Provisional; Region: PRK12747 1246995012763 NAD(P) binding site [chemical binding]; other site 1246995012764 active site 1246995012765 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1246995012766 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1246995012767 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 1246995012768 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1246995012769 putative ADP-binding pocket [chemical binding]; other site 1246995012770 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1246995012771 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1246995012772 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1246995012773 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1246995012774 active site 1246995012775 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1246995012776 classical (c) SDRs; Region: SDR_c; cd05233 1246995012777 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1246995012778 NAD(P) binding site [chemical binding]; other site 1246995012779 active site 1246995012780 DNA polymerase IV; Validated; Region: PRK01810 1246995012781 SEC-C motif; Region: SEC-C; pfam02810 1246995012782 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1246995012783 anti sigma factor interaction site; other site 1246995012784 regulatory phosphorylation site [posttranslational modification]; other site 1246995012785 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1246995012786 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1246995012787 Mg2+ binding site [ion binding]; other site 1246995012788 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1246995012789 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1246995012790 active site 1246995012791 hydroperoxidase II; Provisional; Region: katE; PRK11249 1246995012792 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 1246995012793 heme binding pocket [chemical binding]; other site 1246995012794 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1246995012795 conserved cys residue [active] 1246995012796 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 1246995012797 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 1246995012798 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1246995012799 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1246995012800 putative sugar binding sites [chemical binding]; other site 1246995012801 Q-X-W motif; other site 1246995012802 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1246995012803 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435 1246995012804 oligomerization interface [polypeptide binding]; other site 1246995012805 active site 1246995012806 metal binding site [ion binding]; metal-binding site 1246995012807 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1246995012808 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1246995012809 NAD(P) binding site [chemical binding]; other site 1246995012810 Glycosyltransferase family 28 N-terminal domain; Region: Glyco_transf_28; pfam03033 1246995012811 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1246995012812 Part of AAA domain; Region: AAA_19; pfam13245 1246995012813 Family description; Region: UvrD_C_2; pfam13538 1246995012814 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155 1246995012815 Phosphotransferase enzyme family; Region: APH; pfam01636 1246995012816 putative active site [active] 1246995012817 putative substrate binding site [chemical binding]; other site 1246995012818 ATP binding site [chemical binding]; other site 1246995012819 DoxX-like family; Region: DoxX_2; pfam13564 1246995012820 Animal heme peroxidases and related proteins; Region: An_peroxidase_like; cl14561 1246995012821 heme binding site [chemical binding]; other site 1246995012822 substrate binding site [chemical binding]; other site 1246995012823 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 1246995012824 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995012825 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1246995012826 DNA binding residues [nucleotide binding] 1246995012827 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1246995012828 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995012829 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1246995012830 NAD(P) binding site [chemical binding]; other site 1246995012831 active site 1246995012832 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995012833 active site 1246995012834 phosphorylation site [posttranslational modification] 1246995012835 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1246995012836 intermolecular recognition site; other site 1246995012837 dimerization interface [polypeptide binding]; other site 1246995012838 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1246995012839 DNA binding site [nucleotide binding] 1246995012840 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1246995012841 dimer interface [polypeptide binding]; other site 1246995012842 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1246995012843 phosphorylation site [posttranslational modification] 1246995012844 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995012845 ATP binding site [chemical binding]; other site 1246995012846 Mg2+ binding site [ion binding]; other site 1246995012847 G-X-G motif; other site 1246995012848 Oxidoreductase molybdopterin binding domain; Region: Oxidored_molyb; pfam00174 1246995012849 Moco binding site; other site 1246995012850 metal coordination site [ion binding]; other site 1246995012851 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1246995012852 S-adenosylmethionine binding site [chemical binding]; other site 1246995012853 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 1246995012854 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1246995012855 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1246995012856 Ligand binding site; other site 1246995012857 Putative Catalytic site; other site 1246995012858 DXD motif; other site 1246995012859 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1246995012860 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995012861 NAD(P) binding site [chemical binding]; other site 1246995012862 active site 1246995012863 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 1246995012864 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 1246995012865 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1246995012866 putative hydrophobic ligand binding site [chemical binding]; other site 1246995012867 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1246995012868 putative DNA binding site [nucleotide binding]; other site 1246995012869 dimerization interface [polypeptide binding]; other site 1246995012870 putative Zn2+ binding site [ion binding]; other site 1246995012871 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1246995012872 hydrophobic ligand binding site; other site 1246995012873 FOG: CBS domain [General function prediction only]; Region: COG0517 1246995012874 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 1246995012875 short chain dehydrogenase; Provisional; Region: PRK06701 1246995012876 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1246995012877 NAD binding site [chemical binding]; other site 1246995012878 metal binding site [ion binding]; metal-binding site 1246995012879 active site 1246995012880 Epoxide hydrolase N terminus; Region: EHN; pfam06441 1246995012881 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1246995012882 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1246995012883 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1246995012884 hypothetical protein; Provisional; Region: PRK07236 1246995012885 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1246995012886 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 1246995012887 lichenase, member of glycosyl hydrolase family 16; Region: GH16_lichenase; cd02175 1246995012888 active site 1246995012889 active site 1246995012890 catalytic residues [active] 1246995012891 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 1246995012892 putative dimer interface [polypeptide binding]; other site 1246995012893 catalytic triad [active] 1246995012894 potential frameshift: common BLAST hit: gi|383780556|ref|YP_005465122.1| putative transposase 1246995012895 Helix-turn-helix domain; Region: HTH_38; pfam13936 1246995012896 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1246995012897 Integrase core domain; Region: rve; pfam00665 1246995012898 DDE superfamily endonuclease; Region: DDE_5; pfam13546 1246995012899 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1246995012900 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1246995012901 NodB motif; other site 1246995012902 active site 1246995012903 catalytic site [active] 1246995012904 metal binding site [ion binding]; metal-binding site 1246995012905 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1246995012906 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995012907 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995012908 DNA binding residues [nucleotide binding] 1246995012909 dimerization interface [polypeptide binding]; other site 1246995012910 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1246995012911 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1246995012912 S-adenosylmethionine binding site [chemical binding]; other site 1246995012913 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 1246995012914 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1246995012915 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1246995012916 siderophore binding site; other site 1246995012917 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1246995012918 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1246995012919 ABC-ATPase subunit interface; other site 1246995012920 dimer interface [polypeptide binding]; other site 1246995012921 putative PBP binding regions; other site 1246995012922 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1246995012923 ABC-ATPase subunit interface; other site 1246995012924 dimer interface [polypeptide binding]; other site 1246995012925 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1246995012926 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1246995012927 Walker A/P-loop; other site 1246995012928 ATP binding site [chemical binding]; other site 1246995012929 Q-loop/lid; other site 1246995012930 ABC transporter signature motif; other site 1246995012931 Walker B; other site 1246995012932 D-loop; other site 1246995012933 H-loop/switch region; other site 1246995012934 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995012935 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1246995012936 Walker A/P-loop; other site 1246995012937 ATP binding site [chemical binding]; other site 1246995012938 Q-loop/lid; other site 1246995012939 ABC transporter signature motif; other site 1246995012940 Walker B; other site 1246995012941 D-loop; other site 1246995012942 H-loop/switch region; other site 1246995012943 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1246995012944 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1246995012945 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995012946 Walker A/P-loop; other site 1246995012947 ATP binding site [chemical binding]; other site 1246995012948 Q-loop/lid; other site 1246995012949 ABC transporter signature motif; other site 1246995012950 Walker B; other site 1246995012951 D-loop; other site 1246995012952 H-loop/switch region; other site 1246995012953 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1246995012954 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1246995012955 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1246995012956 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1246995012957 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 1246995012958 putative dimerization interface [polypeptide binding]; other site 1246995012959 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1246995012960 MbtH-like protein; Region: MbtH; pfam03621 1246995012961 Condensation domain; Region: Condensation; pfam00668 1246995012962 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1246995012963 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1246995012964 acyl-activating enzyme (AAE) consensus motif; other site 1246995012965 AMP binding site [chemical binding]; other site 1246995012966 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1246995012967 Condensation domain; Region: Condensation; pfam00668 1246995012968 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1246995012969 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1246995012970 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1246995012971 acyl-activating enzyme (AAE) consensus motif; other site 1246995012972 AMP binding site [chemical binding]; other site 1246995012973 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1246995012974 Condensation domain; Region: Condensation; pfam00668 1246995012975 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1246995012976 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1246995012977 acyl-activating enzyme (AAE) consensus motif; other site 1246995012978 AMP binding site [chemical binding]; other site 1246995012979 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1246995012980 Condensation domain; Region: Condensation; pfam00668 1246995012981 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1246995012982 Condensation domain; Region: Condensation; pfam00668 1246995012983 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1246995012984 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1246995012985 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1246995012986 acyl-activating enzyme (AAE) consensus motif; other site 1246995012987 AMP binding site [chemical binding]; other site 1246995012988 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1246995012989 Condensation domain; Region: Condensation; pfam00668 1246995012990 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1246995012991 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1246995012992 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1246995012993 acyl-activating enzyme (AAE) consensus motif; other site 1246995012994 AMP binding site [chemical binding]; other site 1246995012995 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1246995012996 Condensation domain; Region: Condensation; pfam00668 1246995012997 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1246995012998 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1246995012999 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1246995013000 acyl-activating enzyme (AAE) consensus motif; other site 1246995013001 AMP binding site [chemical binding]; other site 1246995013002 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1246995013003 Condensation domain; Region: Condensation; pfam00668 1246995013004 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1246995013005 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1246995013006 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1246995013007 acyl-activating enzyme (AAE) consensus motif; other site 1246995013008 AMP binding site [chemical binding]; other site 1246995013009 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1246995013010 S-adenosylmethionine binding site [chemical binding]; other site 1246995013011 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1246995013012 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1246995013013 Condensation domain; Region: Condensation; pfam00668 1246995013014 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1246995013015 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1246995013016 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1246995013017 Cupin domain; Region: Cupin_2; pfam07883 1246995013018 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1246995013019 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1246995013020 Bacterial transcriptional regulator; Region: IclR; pfam01614 1246995013021 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995013022 NAD(P) binding site [chemical binding]; other site 1246995013023 active site 1246995013024 Cupin domain; Region: Cupin_2; pfam07883 1246995013025 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1246995013026 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1246995013027 active site 1246995013028 metal binding site [ion binding]; metal-binding site 1246995013029 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 1246995013030 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1246995013031 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1246995013032 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 1246995013033 putative dimerization interface [polypeptide binding]; other site 1246995013034 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1246995013035 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 1246995013036 inhibitor-cofactor binding pocket; inhibition site 1246995013037 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1246995013038 catalytic residue [active] 1246995013039 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995013040 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1246995013041 active site 1246995013042 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1246995013043 active site 1246995013044 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 1246995013045 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 1246995013046 active site 1246995013047 catalytic residues [active] 1246995013048 metal binding site [ion binding]; metal-binding site 1246995013049 DmpG-like communication domain; Region: DmpG_comm; pfam07836 1246995013050 acetaldehyde dehydrogenase; Validated; Region: PRK08300 1246995013051 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1246995013052 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 1246995013053 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1246995013054 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1246995013055 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1246995013056 Bacterial transcriptional regulator; Region: IclR; pfam01614 1246995013057 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 1246995013058 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1246995013059 active site 1246995013060 Class I aldolases; Region: Aldolase_Class_I; cl17187 1246995013061 catalytic residue [active] 1246995013062 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1246995013063 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995013064 NAD(P) binding site [chemical binding]; other site 1246995013065 active site 1246995013066 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995013067 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995013068 Fn3 associated; Region: Fn3_assoc; pfam13287 1246995013069 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1246995013070 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1246995013071 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1246995013072 DNA-binding site [nucleotide binding]; DNA binding site 1246995013073 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1246995013074 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1246995013075 homodimer interface [polypeptide binding]; other site 1246995013076 catalytic residue [active] 1246995013077 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1246995013078 EamA-like transporter family; Region: EamA; pfam00892 1246995013079 Lsr2; Region: Lsr2; pfam11774 1246995013080 short chain dehydrogenase; Provisional; Region: PRK06179 1246995013081 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1246995013082 NADP binding site [chemical binding]; other site 1246995013083 active site 1246995013084 steroid binding site; other site 1246995013085 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 1246995013086 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1246995013087 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1246995013088 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1246995013089 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995013090 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1246995013091 DNA binding residues [nucleotide binding] 1246995013092 YCII-related domain; Region: YCII; cl00999 1246995013093 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1246995013094 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1246995013095 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1246995013096 MarR family; Region: MarR; pfam01047 1246995013097 EamA-like transporter family; Region: EamA; pfam00892 1246995013098 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1246995013099 Integral membrane protein TerC family; Region: TerC; cl10468 1246995013100 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1246995013101 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995013102 NAD(P) binding site [chemical binding]; other site 1246995013103 active site 1246995013104 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1246995013105 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1246995013106 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1246995013107 dimerization interface [polypeptide binding]; other site 1246995013108 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1246995013109 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 1246995013110 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1246995013111 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995013112 dimer interface [polypeptide binding]; other site 1246995013113 conserved gate region; other site 1246995013114 putative PBP binding loops; other site 1246995013115 ABC-ATPase subunit interface; other site 1246995013116 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1246995013117 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995013118 dimer interface [polypeptide binding]; other site 1246995013119 conserved gate region; other site 1246995013120 putative PBP binding loops; other site 1246995013121 ABC-ATPase subunit interface; other site 1246995013122 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1246995013123 homodimer interface [polypeptide binding]; other site 1246995013124 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 1246995013125 active site pocket [active] 1246995013126 CHASE3 domain; Region: CHASE3; pfam05227 1246995013127 HAMP domain; Region: HAMP; pfam00672 1246995013128 dimerization interface [polypeptide binding]; other site 1246995013129 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1246995013130 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1246995013131 dimer interface [polypeptide binding]; other site 1246995013132 phosphorylation site [posttranslational modification] 1246995013133 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995013134 ATP binding site [chemical binding]; other site 1246995013135 Mg2+ binding site [ion binding]; other site 1246995013136 G-X-G motif; other site 1246995013137 GAF domain; Region: GAF; pfam01590 1246995013138 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1246995013139 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1246995013140 dimer interface [polypeptide binding]; other site 1246995013141 phosphorylation site [posttranslational modification] 1246995013142 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995013143 ATP binding site [chemical binding]; other site 1246995013144 Mg2+ binding site [ion binding]; other site 1246995013145 G-X-G motif; other site 1246995013146 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 1246995013147 NADPH bind site [chemical binding]; other site 1246995013148 putative FMN binding site [chemical binding]; other site 1246995013149 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 1246995013150 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995013151 Walker A/P-loop; other site 1246995013152 ATP binding site [chemical binding]; other site 1246995013153 Q-loop/lid; other site 1246995013154 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1246995013155 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995013156 Walker A/P-loop; other site 1246995013157 ATP binding site [chemical binding]; other site 1246995013158 Q-loop/lid; other site 1246995013159 ABC transporter signature motif; other site 1246995013160 Walker B; other site 1246995013161 D-loop; other site 1246995013162 H-loop/switch region; other site 1246995013163 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 1246995013164 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1246995013165 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1246995013166 tetramer interface [polypeptide binding]; other site 1246995013167 active site 1246995013168 Mg2+/Mn2+ binding site [ion binding]; other site 1246995013169 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1246995013170 dimerization interface [polypeptide binding]; other site 1246995013171 putative Zn2+ binding site [ion binding]; other site 1246995013172 putative DNA binding site [nucleotide binding]; other site 1246995013173 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995013174 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1246995013175 NAD(P) binding site [chemical binding]; other site 1246995013176 active site 1246995013177 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1246995013178 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1246995013179 salt bridge; other site 1246995013180 non-specific DNA binding site [nucleotide binding]; other site 1246995013181 sequence-specific DNA binding site [nucleotide binding]; other site 1246995013182 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995013183 Walker A/P-loop; other site 1246995013184 ATP binding site [chemical binding]; other site 1246995013185 ABC transporter; Region: ABC_tran; pfam00005 1246995013186 Q-loop/lid; other site 1246995013187 ABC transporter signature motif; other site 1246995013188 Walker B; other site 1246995013189 D-loop; other site 1246995013190 H-loop/switch region; other site 1246995013191 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1246995013192 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995013193 active site 1246995013194 phosphorylation site [posttranslational modification] 1246995013195 intermolecular recognition site; other site 1246995013196 dimerization interface [polypeptide binding]; other site 1246995013197 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1246995013198 DNA binding site [nucleotide binding] 1246995013199 HAMP domain; Region: HAMP; pfam00672 1246995013200 dimerization interface [polypeptide binding]; other site 1246995013201 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1246995013202 dimer interface [polypeptide binding]; other site 1246995013203 phosphorylation site [posttranslational modification] 1246995013204 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995013205 ATP binding site [chemical binding]; other site 1246995013206 Mg2+ binding site [ion binding]; other site 1246995013207 G-X-G motif; other site 1246995013208 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 1246995013209 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 1246995013210 Carbohydrate Binding Module 6 (CBM6); appended to glycoside hydrolase (GH) domains, including GH5 (cellulase); Region: CBM6_cellulase-like; cd04080 1246995013211 Ca binding site [ion binding]; other site 1246995013212 ligand binding site I [chemical binding]; other site 1246995013213 homodimer interface [polypeptide binding]; other site 1246995013214 ligand binding site II [chemical binding]; other site 1246995013215 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 1246995013216 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995013217 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1246995013218 DNA binding residues [nucleotide binding] 1246995013219 TIGR03089 family protein; Region: TIGR03089 1246995013220 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1246995013221 non-specific DNA binding site [nucleotide binding]; other site 1246995013222 salt bridge; other site 1246995013223 sequence-specific DNA binding site [nucleotide binding]; other site 1246995013224 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 1246995013225 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1246995013226 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1246995013227 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1246995013228 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 1246995013229 putative deacylase active site [active] 1246995013230 CHASE domain; Region: CHASE; pfam03924 1246995013231 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1246995013232 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1246995013233 dimer interface [polypeptide binding]; other site 1246995013234 phosphorylation site [posttranslational modification] 1246995013235 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995013236 ATP binding site [chemical binding]; other site 1246995013237 Mg2+ binding site [ion binding]; other site 1246995013238 G-X-G motif; other site 1246995013239 L-lactate permease; Region: Lactate_perm; cl00701 1246995013240 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1246995013241 L-lactate permease; Region: Lactate_perm; cl00701 1246995013242 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1246995013243 Amino acid permease; Region: AA_permease; pfam00324 1246995013244 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 1246995013245 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1246995013246 non-specific DNA binding site [nucleotide binding]; other site 1246995013247 salt bridge; other site 1246995013248 sequence-specific DNA binding site [nucleotide binding]; other site 1246995013249 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1246995013250 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1246995013251 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 1246995013252 active site 1246995013253 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1246995013254 dimer interface [polypeptide binding]; other site 1246995013255 catalytic residues [active] 1246995013256 substrate binding site [chemical binding]; other site 1246995013257 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 1246995013258 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 1246995013259 putative ligand binding site [chemical binding]; other site 1246995013260 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 1246995013261 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1246995013262 S-adenosylmethionine binding site [chemical binding]; other site 1246995013263 PAS domain S-box; Region: sensory_box; TIGR00229 1246995013264 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1246995013265 putative active site [active] 1246995013266 PAS domain S-box; Region: sensory_box; TIGR00229 1246995013267 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1246995013268 putative active site [active] 1246995013269 heme pocket [chemical binding]; other site 1246995013270 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1246995013271 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1246995013272 putative active site [active] 1246995013273 heme pocket [chemical binding]; other site 1246995013274 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1246995013275 dimer interface [polypeptide binding]; other site 1246995013276 phosphorylation site [posttranslational modification] 1246995013277 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995013278 ATP binding site [chemical binding]; other site 1246995013279 Mg2+ binding site [ion binding]; other site 1246995013280 G-X-G motif; other site 1246995013281 Response regulator receiver domain; Region: Response_reg; pfam00072 1246995013282 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995013283 active site 1246995013284 phosphorylation site [posttranslational modification] 1246995013285 intermolecular recognition site; other site 1246995013286 dimerization interface [polypeptide binding]; other site 1246995013287 Phosphotransferase enzyme family; Region: APH; pfam01636 1246995013288 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 1246995013289 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1246995013290 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 1246995013291 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 1246995013292 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1246995013293 active site 1246995013294 homodimer interface [polypeptide binding]; other site 1246995013295 catalytic site [active] 1246995013296 acceptor binding site [chemical binding]; other site 1246995013297 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995013298 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995013299 active site 1246995013300 phosphorylation site [posttranslational modification] 1246995013301 intermolecular recognition site; other site 1246995013302 dimerization interface [polypeptide binding]; other site 1246995013303 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995013304 dimerization interface [polypeptide binding]; other site 1246995013305 DNA binding residues [nucleotide binding] 1246995013306 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1246995013307 Histidine kinase; Region: HisKA_3; pfam07730 1246995013308 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1246995013309 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1246995013310 Walker A/P-loop; other site 1246995013311 ATP binding site [chemical binding]; other site 1246995013312 Q-loop/lid; other site 1246995013313 ABC transporter signature motif; other site 1246995013314 Walker B; other site 1246995013315 D-loop; other site 1246995013316 H-loop/switch region; other site 1246995013317 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1246995013318 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1246995013319 ligand binding site [chemical binding]; other site 1246995013320 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1246995013321 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1246995013322 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1246995013323 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995013324 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 1246995013325 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1246995013326 putative NAD(P) binding site [chemical binding]; other site 1246995013327 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1246995013328 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1246995013329 Walker A/P-loop; other site 1246995013330 ATP binding site [chemical binding]; other site 1246995013331 Q-loop/lid; other site 1246995013332 ABC transporter signature motif; other site 1246995013333 Walker B; other site 1246995013334 D-loop; other site 1246995013335 H-loop/switch region; other site 1246995013336 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1246995013337 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1246995013338 Walker A/P-loop; other site 1246995013339 ATP binding site [chemical binding]; other site 1246995013340 Q-loop/lid; other site 1246995013341 ABC transporter signature motif; other site 1246995013342 Walker B; other site 1246995013343 D-loop; other site 1246995013344 H-loop/switch region; other site 1246995013345 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1246995013346 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995013347 dimer interface [polypeptide binding]; other site 1246995013348 conserved gate region; other site 1246995013349 putative PBP binding loops; other site 1246995013350 ABC-ATPase subunit interface; other site 1246995013351 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1246995013352 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995013353 dimer interface [polypeptide binding]; other site 1246995013354 conserved gate region; other site 1246995013355 putative PBP binding loops; other site 1246995013356 ABC-ATPase subunit interface; other site 1246995013357 The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506 1246995013358 peptide binding site [polypeptide binding]; other site 1246995013359 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1246995013360 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1246995013361 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 1246995013362 nucleotide binding site [chemical binding]; other site 1246995013363 potential frameshift: common BLAST hit: gi|383779427|ref|YP_005463993.1| putative M20/M25/M40-family peptidase 1246995013364 Predicted metalloprotease [General function prediction only]; Region: COG2321 1246995013365 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1246995013366 Predicted metalloprotease [General function prediction only]; Region: COG2321 1246995013367 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1246995013368 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1246995013369 anti sigma factor interaction site; other site 1246995013370 regulatory phosphorylation site [posttranslational modification]; other site 1246995013371 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1246995013372 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995013373 ATP binding site [chemical binding]; other site 1246995013374 Mg2+ binding site [ion binding]; other site 1246995013375 G-X-G motif; other site 1246995013376 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 1246995013377 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1246995013378 S-adenosylmethionine binding site [chemical binding]; other site 1246995013379 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1246995013380 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1246995013381 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1246995013382 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1246995013383 NAD binding site [chemical binding]; other site 1246995013384 catalytic Zn binding site [ion binding]; other site 1246995013385 structural Zn binding site [ion binding]; other site 1246995013386 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995013387 WHG domain; Region: WHG; pfam13305 1246995013388 short chain dehydrogenase; Validated; Region: PRK06182 1246995013389 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995013390 NAD(P) binding site [chemical binding]; other site 1246995013391 active site 1246995013392 Predicted membrane protein [Function unknown]; Region: COG2246 1246995013393 GtrA-like protein; Region: GtrA; pfam04138 1246995013394 Uncharacterized conserved protein [Function unknown]; Region: COG1432 1246995013395 LabA_like proteins; Region: LabA_like; cd06167 1246995013396 putative metal binding site [ion binding]; other site 1246995013397 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cl14879 1246995013398 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cl14879 1246995013399 enterobactin exporter EntS; Provisional; Region: PRK10489 1246995013400 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1246995013401 putative substrate translocation pore; other site 1246995013402 MarR family; Region: MarR_2; pfam12802 1246995013403 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR8; cd08273 1246995013404 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1246995013405 putative NAD(P) binding site [chemical binding]; other site 1246995013406 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1246995013407 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1246995013408 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 1246995013409 putative dimerization interface [polypeptide binding]; other site 1246995013410 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1246995013411 EamA-like transporter family; Region: EamA; pfam00892 1246995013412 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1246995013413 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995013414 Walker A/P-loop; other site 1246995013415 ATP binding site [chemical binding]; other site 1246995013416 Q-loop/lid; other site 1246995013417 ABC transporter signature motif; other site 1246995013418 Walker B; other site 1246995013419 D-loop; other site 1246995013420 H-loop/switch region; other site 1246995013421 TOBE domain; Region: TOBE_2; pfam08402 1246995013422 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1246995013423 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1246995013424 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995013425 dimer interface [polypeptide binding]; other site 1246995013426 conserved gate region; other site 1246995013427 putative PBP binding loops; other site 1246995013428 ABC-ATPase subunit interface; other site 1246995013429 2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046 1246995013430 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1246995013431 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1246995013432 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995013433 active site 1246995013434 phosphorylation site [posttranslational modification] 1246995013435 intermolecular recognition site; other site 1246995013436 dimerization interface [polypeptide binding]; other site 1246995013437 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1246995013438 DNA binding site [nucleotide binding] 1246995013439 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1246995013440 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1246995013441 dimer interface [polypeptide binding]; other site 1246995013442 phosphorylation site [posttranslational modification] 1246995013443 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995013444 ATP binding site [chemical binding]; other site 1246995013445 Mg2+ binding site [ion binding]; other site 1246995013446 G-X-G motif; other site 1246995013447 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1246995013448 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1246995013449 substrate binding pocket [chemical binding]; other site 1246995013450 active site 1246995013451 iron coordination sites [ion binding]; other site 1246995013452 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1246995013453 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1246995013454 Walker A/P-loop; other site 1246995013455 ATP binding site [chemical binding]; other site 1246995013456 Q-loop/lid; other site 1246995013457 ABC transporter signature motif; other site 1246995013458 Walker B; other site 1246995013459 D-loop; other site 1246995013460 H-loop/switch region; other site 1246995013461 taurine ABC transporter, periplasmic binding protein; Region: taurine_ABC_bnd; TIGR01729 1246995013462 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1246995013463 substrate binding pocket [chemical binding]; other site 1246995013464 membrane-bound complex binding site; other site 1246995013465 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1246995013466 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995013467 dimer interface [polypeptide binding]; other site 1246995013468 conserved gate region; other site 1246995013469 putative PBP binding loops; other site 1246995013470 ABC-ATPase subunit interface; other site 1246995013471 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1246995013472 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1246995013473 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 1246995013474 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 1246995013475 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1246995013476 DNA binding residues [nucleotide binding] 1246995013477 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1246995013478 S-adenosylmethionine binding site [chemical binding]; other site 1246995013479 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1246995013480 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 1246995013481 active site clefts [active] 1246995013482 zinc binding site [ion binding]; other site 1246995013483 dimer interface [polypeptide binding]; other site 1246995013484 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1246995013485 FAD binding domain; Region: FAD_binding_2; pfam00890 1246995013486 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1246995013487 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 1246995013488 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1246995013489 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1246995013490 Domains similar to the eukaryotic reeler domain and bacterial cohesins; Region: Reeler_cohesin_like; cl14606 1246995013491 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1246995013492 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1246995013493 putative substrate translocation pore; other site 1246995013494 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 1246995013495 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1246995013496 DNA binding residues [nucleotide binding] 1246995013497 drug binding residues [chemical binding]; other site 1246995013498 dimer interface [polypeptide binding]; other site 1246995013499 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 1246995013500 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 1246995013501 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1246995013502 sugar binding site [chemical binding]; other site 1246995013503 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1246995013504 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1246995013505 DNA binding site [nucleotide binding] 1246995013506 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1246995013507 ligand binding site [chemical binding]; other site 1246995013508 dimerization interface [polypeptide binding]; other site 1246995013509 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1246995013510 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1246995013511 PAS domain S-box; Region: sensory_box; TIGR00229 1246995013512 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1246995013513 putative active site [active] 1246995013514 heme pocket [chemical binding]; other site 1246995013515 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1246995013516 metal binding site [ion binding]; metal-binding site 1246995013517 active site 1246995013518 I-site; other site 1246995013519 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1246995013520 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 1246995013521 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 1246995013522 G1 box; other site 1246995013523 putative GEF interaction site [polypeptide binding]; other site 1246995013524 GTP/Mg2+ binding site [chemical binding]; other site 1246995013525 Switch I region; other site 1246995013526 G2 box; other site 1246995013527 G3 box; other site 1246995013528 Switch II region; other site 1246995013529 G4 box; other site 1246995013530 G5 box; other site 1246995013531 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 1246995013532 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 1246995013533 Elongation factor G C-terminus. This domain includes the carboxyl terminal regions of elongation factors (EFs) bacterial EF-G, eukaryotic and archeal EF-2 and eukaryotic mitochondrial mtEFG1s and mtEFG2s. This group also includes proteins similar to the...; Region: Elongation_Factor_C; cl02785 1246995013534 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1246995013535 SnoaL-like domain; Region: SnoaL_2; pfam12680 1246995013536 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1246995013537 active site 1246995013538 Predicted permease; Region: DUF318; cl17795 1246995013539 TIGR03943 family protein; Region: TIGR03943 1246995013540 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 1246995013541 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1246995013542 yiaA/B two helix domain; Region: YiaAB; cl01759 1246995013543 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1246995013544 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1246995013545 ATP binding site [chemical binding]; other site 1246995013546 Mg++ binding site [ion binding]; other site 1246995013547 motif III; other site 1246995013548 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1246995013549 nucleotide binding region [chemical binding]; other site 1246995013550 ATP-binding site [chemical binding]; other site 1246995013551 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 1246995013552 RNA binding site [nucleotide binding]; other site 1246995013553 Protein of unknown function (DUF1810); Region: DUF1810; pfam08837 1246995013554 ChaB; Region: ChaB; pfam06150 1246995013555 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 1246995013556 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1246995013557 Histidine kinase; Region: HisKA_3; pfam07730 1246995013558 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995013559 ATP binding site [chemical binding]; other site 1246995013560 Mg2+ binding site [ion binding]; other site 1246995013561 G-X-G motif; other site 1246995013562 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995013563 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995013564 active site 1246995013565 phosphorylation site [posttranslational modification] 1246995013566 intermolecular recognition site; other site 1246995013567 dimerization interface [polypeptide binding]; other site 1246995013568 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995013569 DNA binding residues [nucleotide binding] 1246995013570 dimerization interface [polypeptide binding]; other site 1246995013571 Tannase and feruloyl esterase; Region: Tannase; pfam07519 1246995013572 Domain of unknown function (DUF4262); Region: DUF4262; pfam14081 1246995013573 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 1246995013574 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995013575 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1246995013576 DNA binding residues [nucleotide binding] 1246995013577 CAAX protease self-immunity; Region: Abi; pfam02517 1246995013578 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995013579 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995013580 SnoaL-like domain; Region: SnoaL_2; pfam12680 1246995013581 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 1246995013582 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 1246995013583 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1246995013584 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1246995013585 active site 1246995013586 catalytic tetrad [active] 1246995013587 Short C-terminal domain; Region: SHOCT; pfam09851 1246995013588 classical (c) SDRs; Region: SDR_c; cd05233 1246995013589 NAD(P) binding site [chemical binding]; other site 1246995013590 active site 1246995013591 Domain of unknown function (DUF4037); Region: DUF4037; pfam13228 1246995013592 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1246995013593 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1246995013594 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1246995013595 active site 1246995013596 catalytic site [active] 1246995013597 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1246995013598 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1246995013599 putative substrate translocation pore; other site 1246995013600 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1246995013601 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1246995013602 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1246995013603 AAA domain; Region: AAA_33; pfam13671 1246995013604 AAA domain; Region: AAA_17; pfam13207 1246995013605 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 1246995013606 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1246995013607 anti sigma factor interaction site; other site 1246995013608 regulatory phosphorylation site [posttranslational modification]; other site 1246995013609 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1246995013610 dimerization interface [polypeptide binding]; other site 1246995013611 putative DNA binding site [nucleotide binding]; other site 1246995013612 putative Zn2+ binding site [ion binding]; other site 1246995013613 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1246995013614 hydrophobic ligand binding site; other site 1246995013615 Erythromycin esterase; Region: Erythro_esteras; pfam05139 1246995013616 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1246995013617 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995013618 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1246995013619 DNA binding residues [nucleotide binding] 1246995013620 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1246995013621 AAA domain; Region: AAA_33; pfam13671 1246995013622 active site 1246995013623 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 1246995013624 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 1246995013625 heme-binding site [chemical binding]; other site 1246995013626 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 1246995013627 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1246995013628 Cellulose binding domain; Region: CBM_2; pfam00553 1246995013629 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1246995013630 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1246995013631 nudix motif; other site 1246995013632 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1246995013633 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1246995013634 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1246995013635 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1246995013636 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 1246995013637 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 1246995013638 NPCBM/NEW2 domain; Region: NPCBM; pfam08305 1246995013639 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1246995013640 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1246995013641 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1246995013642 Domain of unknown function (DUF427); Region: DUF427; cl00998 1246995013643 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 1246995013644 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 1246995013645 ANTAR domain; Region: ANTAR; pfam03861 1246995013646 PAS fold; Region: PAS_3; pfam08447 1246995013647 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 1246995013648 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1246995013649 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1246995013650 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1246995013651 Transglutaminase/protease-like homologues; Region: TGc; smart00460 1246995013652 AAA ATPase domain; Region: AAA_16; pfam13191 1246995013653 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1246995013654 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1246995013655 structural tetrad; other site 1246995013656 classical (c) SDRs; Region: SDR_c; cd05233 1246995013657 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 1246995013658 NAD(P) binding site [chemical binding]; other site 1246995013659 active site 1246995013660 RNA polymerase factor sigma-70; Validated; Region: PRK08241 1246995013661 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995013662 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1246995013663 SnoaL-like domain; Region: SnoaL_2; pfam12680 1246995013664 PemK-like protein; Region: PemK; pfam02452 1246995013665 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1246995013666 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1246995013667 metal binding site [ion binding]; metal-binding site 1246995013668 active site 1246995013669 I-site; other site 1246995013670 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1246995013671 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1246995013672 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1246995013673 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1246995013674 metal binding site [ion binding]; metal-binding site 1246995013675 active site 1246995013676 I-site; other site 1246995013677 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1246995013678 Histidine kinase; Region: HisKA_3; pfam07730 1246995013679 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995013680 ATP binding site [chemical binding]; other site 1246995013681 Mg2+ binding site [ion binding]; other site 1246995013682 G-X-G motif; other site 1246995013683 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995013684 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995013685 active site 1246995013686 phosphorylation site [posttranslational modification] 1246995013687 intermolecular recognition site; other site 1246995013688 dimerization interface [polypeptide binding]; other site 1246995013689 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995013690 DNA binding residues [nucleotide binding] 1246995013691 dimerization interface [polypeptide binding]; other site 1246995013692 phosphoglucomutase; Validated; Region: PRK07564 1246995013693 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 1246995013694 active site 1246995013695 substrate binding site [chemical binding]; other site 1246995013696 metal binding site [ion binding]; metal-binding site 1246995013697 CopC domain; Region: CopC; pfam04234 1246995013698 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1246995013699 anti sigma factor interaction site; other site 1246995013700 regulatory phosphorylation site [posttranslational modification]; other site 1246995013701 Protein of unknown function (DUF328); Region: DUF328; cl01143 1246995013702 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1246995013703 MMPL family; Region: MMPL; pfam03176 1246995013704 MMPL family; Region: MMPL; pfam03176 1246995013705 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995013706 NAD(P) binding site [chemical binding]; other site 1246995013707 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995013708 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1246995013709 active site 1246995013710 Predicted transcriptional regulators [Transcription]; Region: COG1733 1246995013711 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1246995013712 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995013713 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1246995013714 NAD(P) binding site [chemical binding]; other site 1246995013715 active site 1246995013716 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1246995013717 S-adenosylmethionine binding site [chemical binding]; other site 1246995013718 Erythromycin esterase; Region: Erythro_esteras; pfam05139 1246995013719 Lamin Tail Domain; Region: LTD; pfam00932 1246995013720 Uncharacterized conserved protein [Function unknown]; Region: COG4279 1246995013721 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 1246995013722 SNF2 Helicase protein; Region: DUF3670; pfam12419 1246995013723 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1246995013724 ATP binding site [chemical binding]; other site 1246995013725 putative Mg++ binding site [ion binding]; other site 1246995013726 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1246995013727 nucleotide binding region [chemical binding]; other site 1246995013728 ATP-binding site [chemical binding]; other site 1246995013729 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1246995013730 Tetratricopeptide repeat; Region: TPR_10; pfam13374 1246995013731 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1246995013732 Tetratricopeptide repeat; Region: TPR_10; pfam13374 1246995013733 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1246995013734 Tetratricopeptide repeat; Region: TPR_10; cl17452 1246995013735 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1246995013736 binding surface 1246995013737 TPR motif; other site 1246995013738 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1246995013739 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1246995013740 putative Zn2+ binding site [ion binding]; other site 1246995013741 putative DNA binding site [nucleotide binding]; other site 1246995013742 dimerization interface [polypeptide binding]; other site 1246995013743 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1246995013744 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1246995013745 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1246995013746 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 1246995013747 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1246995013748 anti sigma factor interaction site; other site 1246995013749 regulatory phosphorylation site [posttranslational modification]; other site 1246995013750 amino acid transporter; Region: 2A0306; TIGR00909 1246995013751 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1246995013752 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1246995013753 Ligand Binding Site [chemical binding]; other site 1246995013754 Universal stress protein family; Region: Usp; pfam00582 1246995013755 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1246995013756 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1246995013757 active site 1246995013758 ATP binding site [chemical binding]; other site 1246995013759 substrate binding site [chemical binding]; other site 1246995013760 activation loop (A-loop); other site 1246995013761 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1246995013762 active site 1246995013763 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 1246995013764 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1246995013765 Putative Catalytic site; other site 1246995013766 DXD motif; other site 1246995013767 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1246995013768 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1246995013769 active site 1246995013770 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1246995013771 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1246995013772 active site 1246995013773 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1246995013774 Protein of unknown function (DUF1616); Region: DUF1616; cl01959 1246995013775 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 1246995013776 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1246995013777 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1246995013778 homodimer interface [polypeptide binding]; other site 1246995013779 NADP binding site [chemical binding]; other site 1246995013780 substrate binding site [chemical binding]; other site 1246995013781 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 1246995013782 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1246995013783 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1246995013784 putative active site [active] 1246995013785 putative metal binding site [ion binding]; other site 1246995013786 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1246995013787 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1246995013788 putative active site [active] 1246995013789 putative metal binding site [ion binding]; other site 1246995013790 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 1246995013791 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1246995013792 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995013793 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1246995013794 Walker A/P-loop; other site 1246995013795 ATP binding site [chemical binding]; other site 1246995013796 Q-loop/lid; other site 1246995013797 ABC transporter signature motif; other site 1246995013798 Walker B; other site 1246995013799 D-loop; other site 1246995013800 H-loop/switch region; other site 1246995013801 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1246995013802 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995013803 Walker A/P-loop; other site 1246995013804 ATP binding site [chemical binding]; other site 1246995013805 Q-loop/lid; other site 1246995013806 ABC transporter signature motif; other site 1246995013807 Walker B; other site 1246995013808 D-loop; other site 1246995013809 H-loop/switch region; other site 1246995013810 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1246995013811 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1246995013812 CAAX protease self-immunity; Region: Abi; pfam02517 1246995013813 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1246995013814 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1246995013815 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1246995013816 DNA binding site [nucleotide binding] 1246995013817 Ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation; Region: PBP1_CatR_like; cd06296 1246995013818 putative ligand binding site [chemical binding]; other site 1246995013819 putative dimerization interface [polypeptide binding]; other site 1246995013820 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 1246995013821 AAA ATPase domain; Region: AAA_16; pfam13191 1246995013822 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995013823 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995013824 DNA binding residues [nucleotide binding] 1246995013825 dimerization interface [polypeptide binding]; other site 1246995013826 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995013827 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 1246995013828 dimer interface [polypeptide binding]; other site 1246995013829 catalytic triad [active] 1246995013830 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1246995013831 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 1246995013832 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1246995013833 FAD binding pocket [chemical binding]; other site 1246995013834 FAD binding motif [chemical binding]; other site 1246995013835 phosphate binding motif [ion binding]; other site 1246995013836 beta-alpha-beta structure motif; other site 1246995013837 NAD binding pocket [chemical binding]; other site 1246995013838 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1246995013839 catalytic loop [active] 1246995013840 iron binding site [ion binding]; other site 1246995013841 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1246995013842 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 1246995013843 putative di-iron ligands [ion binding]; other site 1246995013844 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1246995013845 sugar 1,4-lactone oxidases; Region: FAD_lactone_ox; TIGR01678 1246995013846 FAD binding domain; Region: FAD_binding_4; pfam01565 1246995013847 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 1246995013848 RNA polymerase factor sigma-70; Validated; Region: PRK08241 1246995013849 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995013850 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1246995013851 DNA binding residues [nucleotide binding] 1246995013852 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1246995013853 Interdomain contacts; other site 1246995013854 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1246995013855 Interdomain contacts; other site 1246995013856 Cytokine receptor motif; other site 1246995013857 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1246995013858 Interdomain contacts; other site 1246995013859 Cytokine receptor motif; other site 1246995013860 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1246995013861 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1246995013862 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 1246995013863 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 1246995013864 RibD C-terminal domain; Region: RibD_C; cl17279 1246995013865 hypothetical protein; Reviewed; Region: PRK09588 1246995013866 Uncharacterized protein family UPF0027; Region: UPF0027; cl17455 1246995013867 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1246995013868 Active site serine [active] 1246995013869 AAA ATPase domain; Region: AAA_16; pfam13191 1246995013870 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1246995013871 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1246995013872 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1246995013873 active site 1246995013874 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1246995013875 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1246995013876 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 1246995013877 putative active site [active] 1246995013878 catalytic site [active] 1246995013879 putative metal binding site [ion binding]; other site 1246995013880 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 1246995013881 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 1246995013882 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 1246995013883 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; smart00813 1246995013884 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 1246995013885 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 1246995013886 active site 1246995013887 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 1246995013888 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1246995013889 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1246995013890 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1246995013891 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 1246995013892 Phosphotransferase enzyme family; Region: APH; pfam01636 1246995013893 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1246995013894 AAA domain; Region: AAA_17; pfam13207 1246995013895 Methane oxygenase PmoA; Region: PmoA; pfam14100 1246995013896 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1246995013897 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1246995013898 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1246995013899 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1246995013900 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1246995013901 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1246995013902 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 1246995013903 metal binding site [ion binding]; metal-binding site 1246995013904 substrate binding pocket [chemical binding]; other site 1246995013905 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 1246995013906 glucuronate isomerase; Reviewed; Region: PRK02925 1246995013907 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1246995013908 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1246995013909 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1246995013910 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1246995013911 DNA binding site [nucleotide binding] 1246995013912 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1246995013913 domain linker motif; other site 1246995013914 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1246995013915 dimerization interface [polypeptide binding]; other site 1246995013916 ligand binding site [chemical binding]; other site 1246995013917 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1246995013918 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1246995013919 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1246995013920 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995013921 dimer interface [polypeptide binding]; other site 1246995013922 putative PBP binding loops; other site 1246995013923 ABC-ATPase subunit interface; other site 1246995013924 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1246995013925 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995013926 dimer interface [polypeptide binding]; other site 1246995013927 conserved gate region; other site 1246995013928 putative PBP binding loops; other site 1246995013929 ABC-ATPase subunit interface; other site 1246995013930 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 1246995013931 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995013932 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1246995013933 DNA binding residues [nucleotide binding] 1246995013934 FOG: CBS domain [General function prediction only]; Region: COG0517 1246995013935 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 1246995013936 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995013937 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995013938 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1246995013939 putative catalytic site [active] 1246995013940 putative phosphate binding site [ion binding]; other site 1246995013941 putative metal binding site [ion binding]; other site 1246995013942 PspC domain; Region: PspC; pfam04024 1246995013943 FAD binding domain; Region: FAD_binding_3; pfam01494 1246995013944 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 1246995013945 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1246995013946 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1246995013947 Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177 1246995013948 active site 1246995013949 dimer interface [polypeptide binding]; other site 1246995013950 metal binding site [ion binding]; metal-binding site 1246995013951 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 1246995013952 active site 1246995013953 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1246995013954 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1246995013955 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1246995013956 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1246995013957 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1246995013958 active site 1246995013959 ATP binding site [chemical binding]; other site 1246995013960 substrate binding site [chemical binding]; other site 1246995013961 activation loop (A-loop); other site 1246995013962 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1246995013963 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1246995013964 active site 1246995013965 catalytic tetrad [active] 1246995013966 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1246995013967 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1246995013968 Probable transposase; Region: OrfB_IS605; pfam01385 1246995013969 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1246995013970 potential frameshift: common BLAST hit: gi|226364965|ref|YP_002782748.1| transposase 1246995013971 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1246995013972 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1246995013973 SGNH_hydrolase subfamily, similar to Ruminococcus flavefaciens XynB. Most likely a secreted hydrolase with xylanase activity. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from...; Region: XynB_like; cd01833 1246995013974 active site 1246995013975 catalytic triad [active] 1246995013976 oxyanion hole [active] 1246995013977 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1246995013978 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1246995013979 putative sugar binding sites [chemical binding]; other site 1246995013980 Q-X-W motif; other site 1246995013981 Chitin binding domain; Region: Chitin_bind_3; pfam03067 1246995013982 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1246995013983 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1246995013984 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995013985 dimer interface [polypeptide binding]; other site 1246995013986 conserved gate region; other site 1246995013987 putative PBP binding loops; other site 1246995013988 ABC-ATPase subunit interface; other site 1246995013989 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995013990 conserved gate region; other site 1246995013991 putative PBP binding loops; other site 1246995013992 ABC-ATPase subunit interface; other site 1246995013993 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1246995013994 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1246995013995 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1246995013996 RNA binding surface [nucleotide binding]; other site 1246995013997 Domains similar to the eukaryotic reeler domain and bacterial cohesins; Region: Reeler_cohesin_like; cl14606 1246995013998 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1246995013999 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1246995014000 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1246995014001 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1246995014002 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1246995014003 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1246995014004 catalytic triad [active] 1246995014005 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1246995014006 anti sigma factor interaction site; other site 1246995014007 regulatory phosphorylation site [posttranslational modification]; other site 1246995014008 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 1246995014009 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1246995014010 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 1246995014011 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 1246995014012 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 1246995014013 putative ligand binding site [chemical binding]; other site 1246995014014 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1246995014015 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995014016 Walker A/P-loop; other site 1246995014017 ATP binding site [chemical binding]; other site 1246995014018 Q-loop/lid; other site 1246995014019 ABC transporter signature motif; other site 1246995014020 Walker B; other site 1246995014021 D-loop; other site 1246995014022 H-loop/switch region; other site 1246995014023 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1246995014024 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1246995014025 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1246995014026 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1246995014027 TM-ABC transporter signature motif; other site 1246995014028 Family description; Region: VCBS; pfam13517 1246995014029 Family description; Region: VCBS; pfam13517 1246995014030 Family description; Region: VCBS; pfam13517 1246995014031 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1246995014032 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 1246995014033 dimerization interface [polypeptide binding]; other site 1246995014034 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1246995014035 dimer interface [polypeptide binding]; other site 1246995014036 phosphorylation site [posttranslational modification] 1246995014037 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995014038 ATP binding site [chemical binding]; other site 1246995014039 G-X-G motif; other site 1246995014040 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1246995014041 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995014042 active site 1246995014043 phosphorylation site [posttranslational modification] 1246995014044 intermolecular recognition site; other site 1246995014045 dimerization interface [polypeptide binding]; other site 1246995014046 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1246995014047 DNA binding site [nucleotide binding] 1246995014048 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1246995014049 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1246995014050 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 1246995014051 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 1246995014052 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 1246995014053 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1246995014054 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1246995014055 TM-ABC transporter signature motif; other site 1246995014056 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 1246995014057 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1246995014058 Walker A/P-loop; other site 1246995014059 ATP binding site [chemical binding]; other site 1246995014060 Q-loop/lid; other site 1246995014061 ABC transporter signature motif; other site 1246995014062 Walker B; other site 1246995014063 D-loop; other site 1246995014064 H-loop/switch region; other site 1246995014065 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1246995014066 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 1246995014067 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 1246995014068 putative ligand binding site [chemical binding]; other site 1246995014069 L-arabinose isomerase; Provisional; Region: PRK02929 1246995014070 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 1246995014071 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1246995014072 trimer interface [polypeptide binding]; other site 1246995014073 substrate binding site [chemical binding]; other site 1246995014074 Mn binding site [ion binding]; other site 1246995014075 L-ribulose-5-phosphate 4-epimerase; Validated; Region: PRK06557 1246995014076 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1246995014077 intersubunit interface [polypeptide binding]; other site 1246995014078 active site 1246995014079 Zn2+ binding site [ion binding]; other site 1246995014080 ribulokinase; Provisional; Region: PRK04123 1246995014081 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 1246995014082 N- and C-terminal domain interface [polypeptide binding]; other site 1246995014083 active site 1246995014084 MgATP binding site [chemical binding]; other site 1246995014085 catalytic site [active] 1246995014086 metal binding site [ion binding]; metal-binding site 1246995014087 carbohydrate binding site [chemical binding]; other site 1246995014088 homodimer interface [polypeptide binding]; other site 1246995014089 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1246995014090 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1246995014091 DNA binding site [nucleotide binding] 1246995014092 domain linker motif; other site 1246995014093 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 1246995014094 ligand binding site [chemical binding]; other site 1246995014095 dimerization interface (open form) [polypeptide binding]; other site 1246995014096 dimerization interface (closed form) [polypeptide binding]; other site 1246995014097 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 1246995014098 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 1246995014099 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1246995014100 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1246995014101 Pirin-related protein [General function prediction only]; Region: COG1741 1246995014102 Pirin; Region: Pirin; pfam02678 1246995014103 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1246995014104 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1246995014105 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1246995014106 binding surface 1246995014107 TPR motif; other site 1246995014108 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1246995014109 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1246995014110 metal binding site [ion binding]; metal-binding site 1246995014111 active site 1246995014112 I-site; other site 1246995014113 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 1246995014114 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1246995014115 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1246995014116 FtsX-like permease family; Region: FtsX; pfam02687 1246995014117 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1246995014118 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1246995014119 Walker A/P-loop; other site 1246995014120 ATP binding site [chemical binding]; other site 1246995014121 Q-loop/lid; other site 1246995014122 ABC transporter signature motif; other site 1246995014123 Walker B; other site 1246995014124 D-loop; other site 1246995014125 H-loop/switch region; other site 1246995014126 HlyD family secretion protein; Region: HlyD_3; pfam13437 1246995014127 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1246995014128 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1246995014129 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1246995014130 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1246995014131 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1246995014132 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1246995014133 IgA Peptidase M64; Region: Peptidase_M64; pfam09471 1246995014134 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995014135 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995014136 active site 1246995014137 phosphorylation site [posttranslational modification] 1246995014138 intermolecular recognition site; other site 1246995014139 dimerization interface [polypeptide binding]; other site 1246995014140 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995014141 dimerization interface [polypeptide binding]; other site 1246995014142 DNA binding residues [nucleotide binding] 1246995014143 Histidine kinase; Region: HisKA_3; pfam07730 1246995014144 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995014145 ATP binding site [chemical binding]; other site 1246995014146 Mg2+ binding site [ion binding]; other site 1246995014147 G-X-G motif; other site 1246995014148 FtsX-like permease family; Region: FtsX; pfam02687 1246995014149 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1246995014150 FtsX-like permease family; Region: FtsX; pfam02687 1246995014151 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1246995014152 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1246995014153 Walker A/P-loop; other site 1246995014154 ATP binding site [chemical binding]; other site 1246995014155 Q-loop/lid; other site 1246995014156 ABC transporter signature motif; other site 1246995014157 Walker B; other site 1246995014158 D-loop; other site 1246995014159 H-loop/switch region; other site 1246995014160 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 1246995014161 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1246995014162 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1246995014163 S-adenosylmethionine binding site [chemical binding]; other site 1246995014164 CheW-like domain; Region: CheW; pfam01584 1246995014165 CHASE3 domain; Region: CHASE3; cl05000 1246995014166 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1246995014167 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1246995014168 dimer interface [polypeptide binding]; other site 1246995014169 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1246995014170 putative CheW interface [polypeptide binding]; other site 1246995014171 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1246995014172 putative binding surface; other site 1246995014173 active site 1246995014174 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995014175 ATP binding site [chemical binding]; other site 1246995014176 Mg2+ binding site [ion binding]; other site 1246995014177 G-X-G motif; other site 1246995014178 CheW-like domain; Region: CheW; pfam01584 1246995014179 Response regulator receiver domain; Region: Response_reg; pfam00072 1246995014180 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995014181 active site 1246995014182 phosphorylation site [posttranslational modification] 1246995014183 intermolecular recognition site; other site 1246995014184 dimerization interface [polypeptide binding]; other site 1246995014185 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1246995014186 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995014187 active site 1246995014188 phosphorylation site [posttranslational modification] 1246995014189 intermolecular recognition site; other site 1246995014190 dimerization interface [polypeptide binding]; other site 1246995014191 CheB methylesterase; Region: CheB_methylest; pfam01339 1246995014192 Response regulator receiver domain; Region: Response_reg; pfam00072 1246995014193 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995014194 active site 1246995014195 phosphorylation site [posttranslational modification] 1246995014196 intermolecular recognition site; other site 1246995014197 dimerization interface [polypeptide binding]; other site 1246995014198 Response regulator receiver domain; Region: Response_reg; pfam00072 1246995014199 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995014200 active site 1246995014201 phosphorylation site [posttranslational modification] 1246995014202 intermolecular recognition site; other site 1246995014203 Response regulator receiver domain; Region: Response_reg; pfam00072 1246995014204 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995014205 phosphorylation site [posttranslational modification] 1246995014206 intermolecular recognition site; other site 1246995014207 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1246995014208 dimer interface [polypeptide binding]; other site 1246995014209 phosphorylation site [posttranslational modification] 1246995014210 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995014211 ATP binding site [chemical binding]; other site 1246995014212 Mg2+ binding site [ion binding]; other site 1246995014213 G-X-G motif; other site 1246995014214 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1246995014215 amidase catalytic site [active] 1246995014216 Zn binding residues [ion binding]; other site 1246995014217 substrate binding site [chemical binding]; other site 1246995014218 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1246995014219 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1246995014220 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1246995014221 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1246995014222 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1246995014223 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1246995014224 FtsX-like permease family; Region: FtsX; pfam02687 1246995014225 FtsX-like permease family; Region: FtsX; pfam02687 1246995014226 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1246995014227 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1246995014228 Walker A/P-loop; other site 1246995014229 ATP binding site [chemical binding]; other site 1246995014230 Q-loop/lid; other site 1246995014231 ABC transporter signature motif; other site 1246995014232 Walker B; other site 1246995014233 D-loop; other site 1246995014234 H-loop/switch region; other site 1246995014235 Histidine kinase; Region: HisKA_3; pfam07730 1246995014236 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1246995014237 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995014238 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995014239 active site 1246995014240 phosphorylation site [posttranslational modification] 1246995014241 intermolecular recognition site; other site 1246995014242 dimerization interface [polypeptide binding]; other site 1246995014243 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995014244 DNA binding residues [nucleotide binding] 1246995014245 dimerization interface [polypeptide binding]; other site 1246995014246 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1246995014247 S-adenosylmethionine binding site [chemical binding]; other site 1246995014248 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1246995014249 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1246995014250 Coenzyme A binding pocket [chemical binding]; other site 1246995014251 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1246995014252 MarR family; Region: MarR; pfam01047 1246995014253 Domain of unknown function (DUF305); Region: DUF305; cl17794 1246995014254 Chitin binding domain; Region: Chitin_bind_3; pfam03067 1246995014255 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 1246995014256 PAS domain S-box; Region: sensory_box; TIGR00229 1246995014257 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1246995014258 putative active site [active] 1246995014259 heme pocket [chemical binding]; other site 1246995014260 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1246995014261 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1246995014262 metal binding site [ion binding]; metal-binding site 1246995014263 active site 1246995014264 I-site; other site 1246995014265 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1246995014266 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1246995014267 Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; pfam10069 1246995014268 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1246995014269 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1246995014270 NodB motif; other site 1246995014271 active site 1246995014272 catalytic site [active] 1246995014273 metal binding site [ion binding]; metal-binding site 1246995014274 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1246995014275 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1246995014276 non-specific DNA binding site [nucleotide binding]; other site 1246995014277 salt bridge; other site 1246995014278 sequence-specific DNA binding site [nucleotide binding]; other site 1246995014279 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1246995014280 isocitrate lyase; Provisional; Region: PRK15063 1246995014281 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1246995014282 tetramer interface [polypeptide binding]; other site 1246995014283 active site 1246995014284 Mg2+/Mn2+ binding site [ion binding]; other site 1246995014285 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 1246995014286 malate synthase A; Region: malate_syn_A; TIGR01344 1246995014287 active site 1246995014288 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1246995014289 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1246995014290 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1246995014291 Pectate lyase; Region: Pectate_lyase; pfam03211 1246995014292 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1246995014293 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1246995014294 Coenzyme A binding pocket [chemical binding]; other site 1246995014295 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1246995014296 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1246995014297 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 1246995014298 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 1246995014299 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759 1246995014300 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1246995014301 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1246995014302 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1246995014303 dimer interface [polypeptide binding]; other site 1246995014304 ADP-ribose binding site [chemical binding]; other site 1246995014305 active site 1246995014306 nudix motif; other site 1246995014307 metal binding site [ion binding]; metal-binding site 1246995014308 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 1246995014309 MreB/Mbl protein; Region: MreB_Mbl; pfam06723 1246995014310 nucleotide binding site [chemical binding]; other site 1246995014311 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1246995014312 SBD interface [polypeptide binding]; other site 1246995014313 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 1246995014314 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1246995014315 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1246995014316 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1246995014317 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1246995014318 G1 box; other site 1246995014319 GTP/Mg2+ binding site [chemical binding]; other site 1246995014320 G2 box; other site 1246995014321 Switch I region; other site 1246995014322 G3 box; other site 1246995014323 Switch II region; other site 1246995014324 G4 box; other site 1246995014325 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 1246995014326 Dynamin family; Region: Dynamin_N; pfam00350 1246995014327 G1 box; other site 1246995014328 GTP/Mg2+ binding site [chemical binding]; other site 1246995014329 G2 box; other site 1246995014330 Switch I region; other site 1246995014331 G3 box; other site 1246995014332 Switch II region; other site 1246995014333 G4 box; other site 1246995014334 G5 box; other site 1246995014335 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_2; cd09320 1246995014336 gating phenylalanine in ion channel; other site 1246995014337 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1246995014338 dimerization interface [polypeptide binding]; other site 1246995014339 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 1246995014340 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1246995014341 putative NAD(P) binding site [chemical binding]; other site 1246995014342 Predicted transcriptional regulators [Transcription]; Region: COG1733 1246995014343 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1246995014344 Bacterial Ig-like domain; Region: Big_5; pfam13205 1246995014345 Domain of unknown function (DUF4332); Region: DUF4332; pfam14229 1246995014346 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1246995014347 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 1246995014348 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1246995014349 active site 1246995014350 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1246995014351 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1246995014352 metal binding site [ion binding]; metal-binding site 1246995014353 active site 1246995014354 I-site; other site 1246995014355 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1246995014356 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1246995014357 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1246995014358 metal binding site [ion binding]; metal-binding site 1246995014359 active site 1246995014360 I-site; other site 1246995014361 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1246995014362 TIR domain; Region: TIR_2; pfam13676 1246995014363 AAA ATPase domain; Region: AAA_16; pfam13191 1246995014364 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1246995014365 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1246995014366 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1246995014367 binding surface 1246995014368 TPR motif; other site 1246995014369 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1246995014370 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1246995014371 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1246995014372 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1246995014373 Walker A motif; other site 1246995014374 ATP binding site [chemical binding]; other site 1246995014375 Walker B motif; other site 1246995014376 arginine finger; other site 1246995014377 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1246995014378 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1246995014379 non-specific DNA binding site [nucleotide binding]; other site 1246995014380 salt bridge; other site 1246995014381 sequence-specific DNA binding site [nucleotide binding]; other site 1246995014382 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1246995014383 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1246995014384 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1246995014385 glycosyltransferase, MSMEG_0565 family; Region: MSMEG_0565_glyc; TIGR04047 1246995014386 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1246995014387 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 1246995014388 active site 1246995014389 catalytic triad [active] 1246995014390 dimer interface [polypeptide binding]; other site 1246995014391 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 1246995014392 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1246995014393 active site 1246995014394 catalytic triad [active] 1246995014395 dimer interface [polypeptide binding]; other site 1246995014396 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1246995014397 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 1246995014398 AIR synthase-related protein, MSMEG_0567 C-terminal family; Region: MSMEG_0567_Cter; TIGR04050 1246995014399 dimerization interface [polypeptide binding]; other site 1246995014400 ATP binding site [chemical binding]; other site 1246995014401 radical SAM protein, MSMEG_0568 family; Region: rSAM_MSMEG_0568; TIGR04043 1246995014402 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1246995014403 FeS/SAM binding site; other site 1246995014404 MSMEG_0572 family protein; Region: MSMEG_0572_fam; TIGR04044 1246995014405 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 1246995014406 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 1246995014407 active site 1246995014408 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 1246995014409 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1246995014410 MSMEG_0570 family protein; Region: MSMEG_0570_fam; TIGR04042 1246995014411 Cellulose binding domain; Region: CBM_2; pfam00553 1246995014412 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 1246995014413 Cellulose binding domain; Region: CBM_2; pfam00553 1246995014414 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995014415 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995014416 active site 1246995014417 phosphorylation site [posttranslational modification] 1246995014418 intermolecular recognition site; other site 1246995014419 dimerization interface [polypeptide binding]; other site 1246995014420 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995014421 DNA binding residues [nucleotide binding] 1246995014422 dimerization interface [polypeptide binding]; other site 1246995014423 Histidine kinase; Region: HisKA_3; pfam07730 1246995014424 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1246995014425 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1246995014426 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 1246995014427 active site 1246995014428 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1246995014429 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 1246995014430 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1246995014431 metal ion-dependent adhesion site (MIDAS); other site 1246995014432 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1246995014433 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1246995014434 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 1246995014435 Zn binding site [ion binding]; other site 1246995014436 Protein of unknown function (DUF1211); Region: DUF1211; pfam06736 1246995014437 potential frameshift: common BLAST hit: gi|386850548|ref|YP_006268561.1| filamentation induced by cAMP protein fic 1246995014438 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1246995014439 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 1246995014440 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1246995014441 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 1246995014442 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 1246995014443 metal binding site [ion binding]; metal-binding site 1246995014444 substrate binding pocket [chemical binding]; other site 1246995014445 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1246995014446 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995014447 dimer interface [polypeptide binding]; other site 1246995014448 conserved gate region; other site 1246995014449 putative PBP binding loops; other site 1246995014450 ABC-ATPase subunit interface; other site 1246995014451 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1246995014452 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995014453 putative PBP binding loops; other site 1246995014454 ABC-ATPase subunit interface; other site 1246995014455 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1246995014456 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1246995014457 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1246995014458 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1246995014459 Bacterial transcriptional regulator; Region: IclR; pfam01614 1246995014460 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1246995014461 extended (e) SDRs; Region: SDR_e; cd08946 1246995014462 NAD(P) binding site [chemical binding]; other site 1246995014463 active site 1246995014464 substrate binding site [chemical binding]; other site 1246995014465 2-hydroxy-3-oxopropionate reductase; Region: tartro_sem_red; TIGR01505 1246995014466 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1246995014467 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1246995014468 Caspase domain; Region: Peptidase_C14; pfam00656 1246995014469 Trehalose utilisation; Region: ThuA; pfam06283 1246995014470 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1246995014471 FOG: PKD repeat [General function prediction only]; Region: COG3291 1246995014472 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 1246995014473 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 1246995014474 metal binding site [ion binding]; metal-binding site 1246995014475 ligand binding site [chemical binding]; other site 1246995014476 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1246995014477 sugar binding site [chemical binding]; other site 1246995014478 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1246995014479 sugar binding site [chemical binding]; other site 1246995014480 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1246995014481 putative DNA binding site [nucleotide binding]; other site 1246995014482 putative Zn2+ binding site [ion binding]; other site 1246995014483 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1246995014484 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1246995014485 Uncharacterized conserved protein [Function unknown]; Region: COG3342 1246995014486 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 1246995014487 Putative peptidoglycan binding domain; Region: PG_binding_2; pfam08823 1246995014488 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995014489 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995014490 active site 1246995014491 phosphorylation site [posttranslational modification] 1246995014492 intermolecular recognition site; other site 1246995014493 dimerization interface [polypeptide binding]; other site 1246995014494 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995014495 DNA binding residues [nucleotide binding] 1246995014496 Putative sensor; Region: Sensor; pfam13796 1246995014497 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1246995014498 Histidine kinase; Region: HisKA_3; pfam07730 1246995014499 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1246995014500 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1246995014501 Walker A/P-loop; other site 1246995014502 ATP binding site [chemical binding]; other site 1246995014503 Q-loop/lid; other site 1246995014504 ABC transporter signature motif; other site 1246995014505 Walker B; other site 1246995014506 D-loop; other site 1246995014507 H-loop/switch region; other site 1246995014508 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1246995014509 FtsX-like permease family; Region: FtsX; pfam02687 1246995014510 FtsX-like permease family; Region: FtsX; pfam02687 1246995014511 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 1246995014512 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1246995014513 acyl-activating enzyme (AAE) consensus motif; other site 1246995014514 putative AMP binding site [chemical binding]; other site 1246995014515 putative active site [active] 1246995014516 putative CoA binding site [chemical binding]; other site 1246995014517 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1246995014518 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1246995014519 substrate binding pocket [chemical binding]; other site 1246995014520 membrane-bound complex binding site; other site 1246995014521 hinge residues; other site 1246995014522 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1246995014523 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1246995014524 active site 1246995014525 ATP binding site [chemical binding]; other site 1246995014526 substrate binding site [chemical binding]; other site 1246995014527 activation loop (A-loop); other site 1246995014528 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1246995014529 binding surface 1246995014530 TPR motif; other site 1246995014531 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1246995014532 Double zinc ribbon; Region: DZR; pfam12773 1246995014533 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1246995014534 active site 1246995014535 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1246995014536 metal ion-dependent adhesion site (MIDAS); other site 1246995014537 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1246995014538 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1246995014539 phosphopeptide binding site; other site 1246995014540 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1246995014541 DinB superfamily; Region: DinB_2; pfam12867 1246995014542 SGNH_hydrolase subfamily, similar to Ruminococcus flavefaciens XynB. Most likely a secreted hydrolase with xylanase activity. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from...; Region: XynB_like; cd01833 1246995014543 active site 1246995014544 catalytic triad [active] 1246995014545 oxyanion hole [active] 1246995014546 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1246995014547 sugar binding site [chemical binding]; other site 1246995014548 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1246995014549 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 1246995014550 active site 1246995014551 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1246995014552 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1246995014553 active site 1246995014554 RNA polymerase sigma-70 factor, TIGR02960 family; Region: SigX5 1246995014555 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995014556 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1246995014557 DNA binding residues [nucleotide binding] 1246995014558 SnoaL-like domain; Region: SnoaL_2; pfam12680 1246995014559 Amb_all domain; Region: Amb_all; smart00656 1246995014560 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895 1246995014561 putative hydrophobic ligand binding site [chemical binding]; other site 1246995014562 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 1246995014563 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1246995014564 conserved cys residue [active] 1246995014565 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1246995014566 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995014567 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 1246995014568 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1246995014569 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1246995014570 DNA binding site [nucleotide binding] 1246995014571 domain linker motif; other site 1246995014572 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1246995014573 dimerization interface [polypeptide binding]; other site 1246995014574 ligand binding site [chemical binding]; other site 1246995014575 HEAT repeats; Region: HEAT_2; pfam13646 1246995014576 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 1246995014577 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1246995014578 ATP binding site [chemical binding]; other site 1246995014579 putative Mg++ binding site [ion binding]; other site 1246995014580 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1246995014581 nucleotide binding region [chemical binding]; other site 1246995014582 ATP-binding site [chemical binding]; other site 1246995014583 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 1246995014584 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 1246995014585 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1246995014586 motif II; other site 1246995014587 diacylglycerol kinase; Reviewed; Region: PRK11914 1246995014588 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1246995014589 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1246995014590 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 1246995014591 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 1246995014592 Predicted transcriptional regulator [Transcription]; Region: COG2378 1246995014593 WYL domain; Region: WYL; pfam13280 1246995014594 Predicted transcriptional regulator [Transcription]; Region: COG2378 1246995014595 WYL domain; Region: WYL; pfam13280 1246995014596 Cation efflux family; Region: Cation_efflux; pfam01545 1246995014597 Protein of unknown function (DUF3866); Region: DUF3866; pfam12982 1246995014598 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1246995014599 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1246995014600 S-adenosylmethionine binding site [chemical binding]; other site 1246995014601 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1246995014602 dimerization interface [polypeptide binding]; other site 1246995014603 putative DNA binding site [nucleotide binding]; other site 1246995014604 putative Zn2+ binding site [ion binding]; other site 1246995014605 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 1246995014606 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1246995014607 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995014608 NAD(P) binding site [chemical binding]; other site 1246995014609 active site 1246995014610 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 1246995014611 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1246995014612 active site 1246995014613 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 1246995014614 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 1246995014615 active site 1246995014616 Pup-like protein; Region: Pup; pfam05639 1246995014617 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 1246995014618 proteasome ATPase; Region: pup_AAA; TIGR03689 1246995014619 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1246995014620 Walker A motif; other site 1246995014621 ATP binding site [chemical binding]; other site 1246995014622 Walker B motif; other site 1246995014623 arginine finger; other site 1246995014624 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 1246995014625 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 1246995014626 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1246995014627 S-adenosylmethionine binding site [chemical binding]; other site 1246995014628 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 1246995014629 Peptidase family M50; Region: Peptidase_M50; pfam02163 1246995014630 active site 1246995014631 putative substrate binding region [chemical binding]; other site 1246995014632 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1246995014633 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1246995014634 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995014635 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995014636 active site 1246995014637 phosphorylation site [posttranslational modification] 1246995014638 intermolecular recognition site; other site 1246995014639 dimerization interface [polypeptide binding]; other site 1246995014640 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995014641 DNA binding residues [nucleotide binding] 1246995014642 dimerization interface [polypeptide binding]; other site 1246995014643 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 1246995014644 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1246995014645 Mnt; Region: mnt; PHA01513 1246995014646 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1246995014647 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1246995014648 Walker A/P-loop; other site 1246995014649 ATP binding site [chemical binding]; other site 1246995014650 Q-loop/lid; other site 1246995014651 ABC transporter signature motif; other site 1246995014652 Walker B; other site 1246995014653 D-loop; other site 1246995014654 H-loop/switch region; other site 1246995014655 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1246995014656 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1246995014657 FtsX-like permease family; Region: FtsX; pfam02687 1246995014658 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 1246995014659 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1246995014660 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1246995014661 motif II; other site 1246995014662 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1246995014663 Uncharacterized conserved protein (COG2071); Region: DUF2071; pfam09844 1246995014664 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1246995014665 putative hydrophobic ligand binding site [chemical binding]; other site 1246995014666 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1246995014667 dimerization interface [polypeptide binding]; other site 1246995014668 putative DNA binding site [nucleotide binding]; other site 1246995014669 putative Zn2+ binding site [ion binding]; other site 1246995014670 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1246995014671 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1246995014672 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1246995014673 active site 1246995014674 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1246995014675 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1246995014676 motif II; other site 1246995014677 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1246995014678 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1246995014679 AAA domain; Region: AAA_33; pfam13671 1246995014680 AAA domain; Region: AAA_17; pfam13207 1246995014681 Putative sensor; Region: Sensor; pfam13796 1246995014682 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1246995014683 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995014684 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995014685 active site 1246995014686 phosphorylation site [posttranslational modification] 1246995014687 intermolecular recognition site; other site 1246995014688 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995014689 DNA binding residues [nucleotide binding] 1246995014690 dimerization interface [polypeptide binding]; other site 1246995014691 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 1246995014692 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1246995014693 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 1246995014694 substrate binding pocket [chemical binding]; other site 1246995014695 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1246995014696 B12 binding site [chemical binding]; other site 1246995014697 cobalt ligand [ion binding]; other site 1246995014698 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1246995014699 PAC2 family; Region: PAC2; pfam09754 1246995014700 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1246995014701 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1246995014702 sequence-specific DNA binding site [nucleotide binding]; other site 1246995014703 salt bridge; other site 1246995014704 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1246995014705 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1246995014706 Walker A/P-loop; other site 1246995014707 ATP binding site [chemical binding]; other site 1246995014708 Q-loop/lid; other site 1246995014709 ABC transporter signature motif; other site 1246995014710 Walker B; other site 1246995014711 D-loop; other site 1246995014712 H-loop/switch region; other site 1246995014713 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1246995014714 DNA-binding site [nucleotide binding]; DNA binding site 1246995014715 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995014716 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995014717 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1246995014718 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1246995014719 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1246995014720 S-adenosylmethionine binding site [chemical binding]; other site 1246995014721 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1246995014722 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1246995014723 DNA-binding site [nucleotide binding]; DNA binding site 1246995014724 UTRA domain; Region: UTRA; pfam07702 1246995014725 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1246995014726 MarR family; Region: MarR; pfam01047 1246995014727 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1246995014728 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1246995014729 FMN binding site [chemical binding]; other site 1246995014730 active site 1246995014731 substrate binding site [chemical binding]; other site 1246995014732 catalytic residue [active] 1246995014733 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1246995014734 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 1246995014735 active site 1246995014736 HIGH motif; other site 1246995014737 nucleotide binding site [chemical binding]; other site 1246995014738 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1246995014739 active site 1246995014740 KMSKS motif; other site 1246995014741 Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955 1246995014742 putative tRNA binding surface [nucleotide binding]; other site 1246995014743 conserved hypothetical protein; Region: TIGR03843 1246995014744 Protein of unknown function (DUF3090); Region: DUF3090; pfam11290 1246995014745 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1246995014746 catalytic core [active] 1246995014747 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1246995014748 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 1246995014749 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1246995014750 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1246995014751 active site 1246995014752 catalytic tetrad [active] 1246995014753 Domain of unknown function (DUF3291); Region: DUF3291; pfam11695 1246995014754 Helix-turn-helix domain; Region: HTH_20; pfam12840 1246995014755 putative DNA binding site [nucleotide binding]; other site 1246995014756 Predicted transcriptional regulator [Transcription]; Region: COG2345 1246995014757 putative Zn2+ binding site [ion binding]; other site 1246995014758 hypothetical protein; Provisional; Region: PRK07906 1246995014759 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 1246995014760 putative metal binding site [ion binding]; other site 1246995014761 Hemerythrin-like domain; Region: Hr-like; cd12108 1246995014762 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1246995014763 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1246995014764 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1246995014765 dimerization interface [polypeptide binding]; other site 1246995014766 substrate binding pocket [chemical binding]; other site 1246995014767 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1246995014768 Clp amino terminal domain; Region: Clp_N; pfam02861 1246995014769 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1246995014770 Walker A motif; other site 1246995014771 ATP binding site [chemical binding]; other site 1246995014772 Walker B motif; other site 1246995014773 arginine finger; other site 1246995014774 UvrB/uvrC motif; Region: UVR; pfam02151 1246995014775 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1246995014776 Walker A motif; other site 1246995014777 ATP binding site [chemical binding]; other site 1246995014778 Walker B motif; other site 1246995014779 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1246995014780 formylmethanofuran dehydrogenase subunit B; Region: one_C_dehyd_B; TIGR03129 1246995014781 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1246995014782 Cupin superfamily protein; Region: Cupin_4; pfam08007 1246995014783 Cupin-like domain; Region: Cupin_8; pfam13621 1246995014784 Protein of unknown function DUF72; Region: DUF72; pfam01904 1246995014785 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 1246995014786 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1246995014787 homodimer interface [polypeptide binding]; other site 1246995014788 substrate-cofactor binding pocket; other site 1246995014789 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1246995014790 catalytic residue [active] 1246995014791 Protein of unknown function DUF72; Region: DUF72; pfam01904 1246995014792 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 1246995014793 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1246995014794 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1246995014795 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1246995014796 DNA binding site [nucleotide binding] 1246995014797 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1246995014798 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1246995014799 Protein of unknown function (DUF3500); Region: DUF3500; pfam12006 1246995014800 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 1246995014801 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1246995014802 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1246995014803 nucleotide binding region [chemical binding]; other site 1246995014804 ATP-binding site [chemical binding]; other site 1246995014805 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1246995014806 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1246995014807 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995014808 Walker A/P-loop; other site 1246995014809 ATP binding site [chemical binding]; other site 1246995014810 Q-loop/lid; other site 1246995014811 ABC transporter signature motif; other site 1246995014812 Walker B; other site 1246995014813 D-loop; other site 1246995014814 H-loop/switch region; other site 1246995014815 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1246995014816 anti sigma factor interaction site; other site 1246995014817 regulatory phosphorylation site [posttranslational modification]; other site 1246995014818 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1246995014819 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1246995014820 CheB methylesterase; Region: CheB_methylest; pfam01339 1246995014821 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1246995014822 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1246995014823 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1246995014824 S-adenosylmethionine binding site [chemical binding]; other site 1246995014825 PAS domain; Region: PAS_9; pfam13426 1246995014826 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1246995014827 putative active site [active] 1246995014828 heme pocket [chemical binding]; other site 1246995014829 PAS fold; Region: PAS_4; pfam08448 1246995014830 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1246995014831 putative active site [active] 1246995014832 heme pocket [chemical binding]; other site 1246995014833 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1246995014834 anti sigma factor interaction site; other site 1246995014835 regulatory phosphorylation site [posttranslational modification]; other site 1246995014836 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1246995014837 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 1246995014838 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995014839 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1246995014840 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1246995014841 DNA binding residues [nucleotide binding] 1246995014842 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1246995014843 anti sigma factor interaction site; other site 1246995014844 regulatory phosphorylation site [posttranslational modification]; other site 1246995014845 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK12323 1246995014846 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 1246995014847 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830 1246995014848 active site 1246995014849 catalytic triad [active] 1246995014850 oxyanion hole [active] 1246995014851 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1246995014852 integral membrane protein; Region: integ_memb_HG; TIGR03954 1246995014853 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1246995014854 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1246995014855 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1246995014856 Coenzyme A binding pocket [chemical binding]; other site 1246995014857 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1246995014858 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995014859 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995014860 active site 1246995014861 phosphorylation site [posttranslational modification] 1246995014862 intermolecular recognition site; other site 1246995014863 dimerization interface [polypeptide binding]; other site 1246995014864 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995014865 DNA binding residues [nucleotide binding] 1246995014866 dimerization interface [polypeptide binding]; other site 1246995014867 GAF domain; Region: GAF_3; pfam13492 1246995014868 Histidine kinase; Region: HisKA_3; pfam07730 1246995014869 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1246995014870 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995014871 ATP binding site [chemical binding]; other site 1246995014872 Mg2+ binding site [ion binding]; other site 1246995014873 G-X-G motif; other site 1246995014874 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1246995014875 sequence-specific DNA binding site [nucleotide binding]; other site 1246995014876 salt bridge; other site 1246995014877 Isochorismatase family; Region: Isochorismatase; pfam00857 1246995014878 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1246995014879 catalytic triad [active] 1246995014880 conserved cis-peptide bond; other site 1246995014881 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 1246995014882 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1246995014883 S-adenosylmethionine binding site [chemical binding]; other site 1246995014884 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995014885 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995014886 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 1246995014887 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1246995014888 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 1246995014889 catalytic triad [active] 1246995014890 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1246995014891 cob(I)alamin adenolsyltransferase/cobinamide ATP-dependent adenolsyltransferase; Validated; Region: PRK05986 1246995014892 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1246995014893 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1246995014894 metal ion-dependent adhesion site (MIDAS); other site 1246995014895 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 1246995014896 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 1246995014897 N- and C-terminal domain interface [polypeptide binding]; other site 1246995014898 active site 1246995014899 carbohydrate binding site [chemical binding]; other site 1246995014900 ATP binding site [chemical binding]; other site 1246995014901 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 1246995014902 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995014903 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1246995014904 DNA binding residues [nucleotide binding] 1246995014905 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 1246995014906 putative hydrophobic ligand binding site [chemical binding]; other site 1246995014907 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1246995014908 dimerization interface [polypeptide binding]; other site 1246995014909 putative DNA binding site [nucleotide binding]; other site 1246995014910 putative Zn2+ binding site [ion binding]; other site 1246995014911 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1246995014912 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1246995014913 homodimer interface [polypeptide binding]; other site 1246995014914 active site 1246995014915 TDP-binding site; other site 1246995014916 acceptor substrate-binding pocket; other site 1246995014917 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1246995014918 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1246995014919 dimer interface [polypeptide binding]; other site 1246995014920 active site 1246995014921 citrylCoA binding site [chemical binding]; other site 1246995014922 NADH binding [chemical binding]; other site 1246995014923 cationic pore residues; other site 1246995014924 oxalacetate/citrate binding site [chemical binding]; other site 1246995014925 coenzyme A binding site [chemical binding]; other site 1246995014926 catalytic triad [active] 1246995014927 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1246995014928 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1246995014929 metal binding site [ion binding]; metal-binding site 1246995014930 active site 1246995014931 I-site; other site 1246995014932 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1246995014933 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1246995014934 putative catalytic site [active] 1246995014935 putative metal binding site [ion binding]; other site 1246995014936 putative phosphate binding site [ion binding]; other site 1246995014937 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1246995014938 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 1246995014939 B12 binding domain; Region: B12-binding_2; pfam02607 1246995014940 B12 binding domain; Region: B12-binding; pfam02310 1246995014941 B12 binding site [chemical binding]; other site 1246995014942 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1246995014943 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1246995014944 Coenzyme A binding pocket [chemical binding]; other site 1246995014945 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1246995014946 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1246995014947 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1246995014948 metal binding site [ion binding]; metal-binding site 1246995014949 active site 1246995014950 I-site; other site 1246995014951 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1246995014952 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 1246995014953 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1246995014954 ATP binding site [chemical binding]; other site 1246995014955 putative Mg++ binding site [ion binding]; other site 1246995014956 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1246995014957 nucleotide binding region [chemical binding]; other site 1246995014958 ATP-binding site [chemical binding]; other site 1246995014959 Helicase associated domain (HA2); Region: HA2; pfam04408 1246995014960 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1246995014961 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1246995014962 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1246995014963 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1246995014964 active site 1246995014965 catalytic tetrad [active] 1246995014966 Response regulator receiver domain; Region: Response_reg; pfam00072 1246995014967 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995014968 active site 1246995014969 phosphorylation site [posttranslational modification] 1246995014970 intermolecular recognition site; other site 1246995014971 dimerization interface [polypeptide binding]; other site 1246995014972 This domain is found in the extracellular portion of receptor-like proteins - such as serine/threonine kinases and adenylyl cyclases; Region: CHASE; smart01079 1246995014973 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1246995014974 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1246995014975 dimer interface [polypeptide binding]; other site 1246995014976 phosphorylation site [posttranslational modification] 1246995014977 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995014978 ATP binding site [chemical binding]; other site 1246995014979 Mg2+ binding site [ion binding]; other site 1246995014980 G-X-G motif; other site 1246995014981 Bacterial SH3 domain; Region: SH3_3; cl17532 1246995014982 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 1246995014983 PAP2 superfamily; Region: PAP2; pfam01569 1246995014984 active site 1246995014985 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 1246995014986 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995014987 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1246995014988 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1246995014989 DNA binding residues [nucleotide binding] 1246995014990 GAF domain; Region: GAF_3; pfam13492 1246995014991 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1246995014992 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1246995014993 metal binding site [ion binding]; metal-binding site 1246995014994 active site 1246995014995 I-site; other site 1246995014996 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1246995014997 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1246995014998 active site 1246995014999 catalytic residues [active] 1246995015000 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1246995015001 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1246995015002 nucleotide binding site [chemical binding]; other site 1246995015003 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1246995015004 DNA-binding transcriptional regulator AgaR; Provisional; Region: PRK09802 1246995015005 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 1246995015006 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995015007 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1246995015008 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1246995015009 S-adenosylmethionine binding site [chemical binding]; other site 1246995015010 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 1246995015011 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 1246995015012 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1246995015013 active site 1246995015014 homodimer interface [polypeptide binding]; other site 1246995015015 catalytic site [active] 1246995015016 acceptor binding site [chemical binding]; other site 1246995015017 trehalose synthase; Region: treS_nterm; TIGR02456 1246995015018 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 1246995015019 active site 1246995015020 catalytic site [active] 1246995015021 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 1246995015022 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 1246995015023 glycogen branching enzyme; Provisional; Region: PRK05402 1246995015024 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1246995015025 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1246995015026 active site 1246995015027 catalytic site [active] 1246995015028 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1246995015029 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1246995015030 Coenzyme A binding pocket [chemical binding]; other site 1246995015031 Nucleotidyltransferase domain; Region: NTP_transf_2; pfam01909 1246995015032 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1246995015033 dimer interface [polypeptide binding]; other site 1246995015034 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1246995015035 Protein of unknown function (DUF419); Region: DUF419; pfam04237 1246995015036 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1246995015037 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1246995015038 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 1246995015039 Catalytic site [active] 1246995015040 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1246995015041 active site 1246995015042 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995015043 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995015044 DNA binding residues [nucleotide binding] 1246995015045 dimerization interface [polypeptide binding]; other site 1246995015046 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1246995015047 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 1246995015048 catalytic Zn binding site [ion binding]; other site 1246995015049 NAD(P) binding site [chemical binding]; other site 1246995015050 structural Zn binding site [ion binding]; other site 1246995015051 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1246995015052 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1246995015053 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1246995015054 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1246995015055 RNA binding site [nucleotide binding]; other site 1246995015056 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1246995015057 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1246995015058 active site 1246995015059 ATP binding site [chemical binding]; other site 1246995015060 substrate binding site [chemical binding]; other site 1246995015061 activation loop (A-loop); other site 1246995015062 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1246995015063 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1246995015064 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1246995015065 dimerization interface [polypeptide binding]; other site 1246995015066 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 1246995015067 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 1246995015068 putative hydrophobic ligand binding site [chemical binding]; other site 1246995015069 MoxR-like ATPases [General function prediction only]; Region: COG0714 1246995015070 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1246995015071 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1246995015072 Ligand binding site; other site 1246995015073 metal-binding site 1246995015074 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1246995015075 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1246995015076 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1246995015077 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 1246995015078 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 1246995015079 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1246995015080 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1246995015081 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1246995015082 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1246995015083 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 1246995015084 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 1246995015085 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995015086 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995015087 active site 1246995015088 phosphorylation site [posttranslational modification] 1246995015089 intermolecular recognition site; other site 1246995015090 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995015091 DNA binding residues [nucleotide binding] 1246995015092 dimerization interface [polypeptide binding]; other site 1246995015093 Histidine kinase; Region: HisKA_3; pfam07730 1246995015094 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1246995015095 ATP binding site [chemical binding]; other site 1246995015096 Mg2+ binding site [ion binding]; other site 1246995015097 G-X-G motif; other site 1246995015098 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1246995015099 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1246995015100 active site 1246995015101 ATP binding site [chemical binding]; other site 1246995015102 substrate binding site [chemical binding]; other site 1246995015103 activation loop (A-loop); other site 1246995015104 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1246995015105 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1246995015106 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1246995015107 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1246995015108 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 1246995015109 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 1246995015110 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 1246995015111 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 1246995015112 Domain of unknown function (DUF305); Region: DUF305; pfam03713 1246995015113 Protein of unknown function (DUF3455); Region: DUF3455; pfam11937 1246995015114 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1246995015115 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1246995015116 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 1246995015117 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1246995015118 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1246995015119 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1246995015120 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1246995015121 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1246995015122 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1246995015123 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1246995015124 Interdomain contacts; other site 1246995015125 Cytokine receptor motif; other site 1246995015126 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 1246995015127 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1246995015128 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 1246995015129 Cellulose binding domain; Region: CBM_2; pfam00553 1246995015130 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 1246995015131 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 1246995015132 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1246995015133 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995015134 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995015135 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1246995015136 putative catalytic site [active] 1246995015137 putative phosphate binding site [ion binding]; other site 1246995015138 putative metal binding site [ion binding]; other site 1246995015139 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1246995015140 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1246995015141 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1246995015142 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1246995015143 intermolecular salt bridges; other site 1246995015144 calcium mediated ligand binding site; other site 1246995015145 CutC family; Region: CutC; cl01218 1246995015146 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1246995015147 active site 1246995015148 substrate binding site [chemical binding]; other site 1246995015149 ATP binding site [chemical binding]; other site 1246995015150 Phosphotransferase enzyme family; Region: APH; pfam01636 1246995015151 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1246995015152 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1246995015153 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1246995015154 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1246995015155 GAF domain; Region: GAF_3; pfam13492 1246995015156 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1246995015157 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1246995015158 metal binding site [ion binding]; metal-binding site 1246995015159 active site 1246995015160 I-site; other site 1246995015161 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1246995015162 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1246995015163 DNA binding site [nucleotide binding] 1246995015164 domain linker motif; other site 1246995015165 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1246995015166 dimerization interface [polypeptide binding]; other site 1246995015167 ligand binding site [chemical binding]; other site 1246995015168 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1246995015169 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1246995015170 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 1246995015171 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995015172 ABC-ATPase subunit interface; other site 1246995015173 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1246995015174 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995015175 dimer interface [polypeptide binding]; other site 1246995015176 conserved gate region; other site 1246995015177 putative PBP binding loops; other site 1246995015178 ABC-ATPase subunit interface; other site 1246995015179 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1246995015180 conserved cys residue [active] 1246995015181 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1246995015182 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1246995015183 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1246995015184 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1246995015185 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1246995015186 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1246995015187 S-adenosylmethionine binding site [chemical binding]; other site 1246995015188 Beta-lactamase; Region: Beta-lactamase; pfam00144 1246995015189 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1246995015190 acyl-coenzyme A oxidase; Region: PLN02526 1246995015191 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1246995015192 active site 1246995015193 glycyl-tRNA synthetase; Provisional; Region: PRK14908 1246995015194 glycyl-tRNA synthetase subunit alpha; Validated; Region: glyQ; PRK09348 1246995015195 motif 1; other site 1246995015196 dimer interface [polypeptide binding]; other site 1246995015197 active site 1246995015198 motif 2; other site 1246995015199 motif 3; other site 1246995015200 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1246995015201 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1246995015202 hypothetical protein; Provisional; Region: PRK07236 1246995015203 hypothetical protein; Validated; Region: PRK05868 1246995015204 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1246995015205 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1246995015206 FAD binding pocket [chemical binding]; other site 1246995015207 conserved FAD binding motif [chemical binding]; other site 1246995015208 phosphate binding motif [ion binding]; other site 1246995015209 beta-alpha-beta structure motif; other site 1246995015210 NAD binding pocket [chemical binding]; other site 1246995015211 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 1246995015212 Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602 1246995015213 putative active site [active] 1246995015214 catalytic site [active] 1246995015215 putative metal binding site [ion binding]; other site 1246995015216 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995015217 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995015218 DNA binding residues [nucleotide binding] 1246995015219 dimerization interface [polypeptide binding]; other site 1246995015220 glycerol kinase; Provisional; Region: glpK; PRK00047 1246995015221 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 1246995015222 N- and C-terminal domain interface [polypeptide binding]; other site 1246995015223 active site 1246995015224 MgATP binding site [chemical binding]; other site 1246995015225 catalytic site [active] 1246995015226 metal binding site [ion binding]; metal-binding site 1246995015227 putative homotetramer interface [polypeptide binding]; other site 1246995015228 glycerol binding site [chemical binding]; other site 1246995015229 homodimer interface [polypeptide binding]; other site 1246995015230 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1246995015231 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1246995015232 Bacterial transcriptional regulator; Region: IclR; pfam01614 1246995015233 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 1246995015234 amphipathic channel; other site 1246995015235 Asn-Pro-Ala signature motifs; other site 1246995015236 glycerol kinase; Provisional; Region: glpK; PRK00047 1246995015237 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 1246995015238 N- and C-terminal domain interface [polypeptide binding]; other site 1246995015239 active site 1246995015240 MgATP binding site [chemical binding]; other site 1246995015241 catalytic site [active] 1246995015242 metal binding site [ion binding]; metal-binding site 1246995015243 putative homotetramer interface [polypeptide binding]; other site 1246995015244 glycerol binding site [chemical binding]; other site 1246995015245 homodimer interface [polypeptide binding]; other site 1246995015246 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1246995015247 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1246995015248 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1246995015249 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1246995015250 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995015251 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995015252 SnoaL-like domain; Region: SnoaL_2; pfam12680 1246995015253 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1246995015254 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1246995015255 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 1246995015256 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1246995015257 DNA binding site [nucleotide binding] 1246995015258 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1246995015259 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1246995015260 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1246995015261 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 1246995015262 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1246995015263 active site 1246995015264 metal binding site [ion binding]; metal-binding site 1246995015265 hexamer interface [polypeptide binding]; other site 1246995015266 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 1246995015267 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1246995015268 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 1246995015269 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1246995015270 inhibitor-cofactor binding pocket; inhibition site 1246995015271 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1246995015272 catalytic residue [active] 1246995015273 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1246995015274 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1246995015275 DNA-binding site [nucleotide binding]; DNA binding site 1246995015276 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1246995015277 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1246995015278 homodimer interface [polypeptide binding]; other site 1246995015279 catalytic residue [active] 1246995015280 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 1246995015281 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 1246995015282 active site 1246995015283 catalytic triad [active] 1246995015284 dimer interface [polypeptide binding]; other site 1246995015285 phenylhydantoinase; Validated; Region: PRK08323 1246995015286 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 1246995015287 tetramer interface [polypeptide binding]; other site 1246995015288 active site 1246995015289 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1246995015290 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1246995015291 tetrameric interface [polypeptide binding]; other site 1246995015292 NAD binding site [chemical binding]; other site 1246995015293 catalytic residues [active] 1246995015294 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1246995015295 F420-dependent oxidoreductase, CPS_4043 family; Region: F420_CPS_4043; TIGR03842 1246995015296 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995015297 dimer interface [polypeptide binding]; other site 1246995015298 conserved gate region; other site 1246995015299 ABC-ATPase subunit interface; other site 1246995015300 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1246995015301 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1246995015302 Walker A/P-loop; other site 1246995015303 ATP binding site [chemical binding]; other site 1246995015304 Q-loop/lid; other site 1246995015305 ABC transporter signature motif; other site 1246995015306 Walker B; other site 1246995015307 D-loop; other site 1246995015308 H-loop/switch region; other site 1246995015309 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1246995015310 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995015311 dimer interface [polypeptide binding]; other site 1246995015312 conserved gate region; other site 1246995015313 putative PBP binding loops; other site 1246995015314 ABC-ATPase subunit interface; other site 1246995015315 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1246995015316 NMT1/THI5 like; Region: NMT1; pfam09084 1246995015317 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1246995015318 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 1246995015319 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1246995015320 FOG: PKD repeat [General function prediction only]; Region: COG3291 1246995015321 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 1246995015322 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1246995015323 Predicted membrane protein [Function unknown]; Region: COG3601 1246995015324 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1246995015325 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1246995015326 metal binding site [ion binding]; metal-binding site 1246995015327 active site 1246995015328 I-site; other site 1246995015329 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1246995015330 MarR family; Region: MarR_2; pfam12802 1246995015331 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1246995015332 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1246995015333 D-xylose ABC transporter, substrate-binding protein; Region: xylF; TIGR02634 1246995015334 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 1246995015335 putative ligand binding site [chemical binding]; other site 1246995015336 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1246995015337 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1246995015338 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1246995015339 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1246995015340 TM-ABC transporter signature motif; other site 1246995015341 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1246995015342 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1246995015343 Walker A/P-loop; other site 1246995015344 ATP binding site [chemical binding]; other site 1246995015345 Q-loop/lid; other site 1246995015346 ABC transporter signature motif; other site 1246995015347 Walker B; other site 1246995015348 D-loop; other site 1246995015349 H-loop/switch region; other site 1246995015350 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1246995015351 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1246995015352 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995015353 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995015354 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1246995015355 MarR family; Region: MarR_2; pfam12802 1246995015356 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1246995015357 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1246995015358 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995015359 Walker A/P-loop; other site 1246995015360 ATP binding site [chemical binding]; other site 1246995015361 Q-loop/lid; other site 1246995015362 ABC transporter signature motif; other site 1246995015363 Walker B; other site 1246995015364 D-loop; other site 1246995015365 H-loop/switch region; other site 1246995015366 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1246995015367 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1246995015368 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1246995015369 dimer interface [polypeptide binding]; other site 1246995015370 phosphorylation site [posttranslational modification] 1246995015371 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995015372 ATP binding site [chemical binding]; other site 1246995015373 Mg2+ binding site [ion binding]; other site 1246995015374 G-X-G motif; other site 1246995015375 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1246995015376 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995015377 active site 1246995015378 phosphorylation site [posttranslational modification] 1246995015379 intermolecular recognition site; other site 1246995015380 dimerization interface [polypeptide binding]; other site 1246995015381 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1246995015382 DNA binding site [nucleotide binding] 1246995015383 HlyD family secretion protein; Region: HlyD_3; pfam13437 1246995015384 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1246995015385 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1246995015386 Walker A/P-loop; other site 1246995015387 ATP binding site [chemical binding]; other site 1246995015388 Q-loop/lid; other site 1246995015389 ABC transporter signature motif; other site 1246995015390 Walker B; other site 1246995015391 D-loop; other site 1246995015392 H-loop/switch region; other site 1246995015393 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1246995015394 FtsX-like permease family; Region: FtsX; pfam02687 1246995015395 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1246995015396 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1246995015397 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1246995015398 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1246995015399 S-adenosylmethionine binding site [chemical binding]; other site 1246995015400 DDE superfamily endonuclease; Region: DDE_5; pfam13546 1246995015401 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1246995015402 active site 1246995015403 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1246995015404 DNA-binding site [nucleotide binding]; DNA binding site 1246995015405 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 1246995015406 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 1246995015407 acyl-activating enzyme (AAE) consensus motif; other site 1246995015408 putative AMP binding site [chemical binding]; other site 1246995015409 putative active site [active] 1246995015410 putative CoA binding site [chemical binding]; other site 1246995015411 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1246995015412 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1246995015413 active site 1246995015414 catalytic site [active] 1246995015415 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 1246995015416 carbohydrate binding site [chemical binding]; other site 1246995015417 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 1246995015418 carbohydrate binding site [chemical binding]; other site 1246995015419 alpha-1,6-glucosidases, pullulanase-type; Region: pullul_strch; TIGR02103 1246995015420 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 1246995015421 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 1246995015422 Ca binding site [ion binding]; other site 1246995015423 active site 1246995015424 catalytic site [active] 1246995015425 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 1246995015426 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 1246995015427 active site 1246995015428 catalytic site [active] 1246995015429 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1246995015430 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1246995015431 FAD binding pocket [chemical binding]; other site 1246995015432 FAD binding motif [chemical binding]; other site 1246995015433 phosphate binding motif [ion binding]; other site 1246995015434 NAD binding pocket [chemical binding]; other site 1246995015435 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1246995015436 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1246995015437 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1246995015438 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12844 1246995015439 NifT/FixU protein; Region: NifT; cl02351 1246995015440 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 1246995015441 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 1246995015442 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1246995015443 molybdopterin cofactor binding site; other site 1246995015444 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 1246995015445 molybdopterin cofactor binding site; other site 1246995015446 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 1246995015447 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 1246995015448 tetrameric interface [polypeptide binding]; other site 1246995015449 NAD binding site [chemical binding]; other site 1246995015450 catalytic residues [active] 1246995015451 substrate binding site [chemical binding]; other site 1246995015452 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 1246995015453 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1246995015454 inhibitor-cofactor binding pocket; inhibition site 1246995015455 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1246995015456 catalytic residue [active] 1246995015457 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 1246995015458 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1246995015459 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1246995015460 putative DNA binding site [nucleotide binding]; other site 1246995015461 putative Zn2+ binding site [ion binding]; other site 1246995015462 AsnC family; Region: AsnC_trans_reg; pfam01037 1246995015463 hypothetical protein; Provisional; Region: PRK06541 1246995015464 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1246995015465 inhibitor-cofactor binding pocket; inhibition site 1246995015466 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1246995015467 catalytic residue [active] 1246995015468 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1246995015469 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1246995015470 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995015471 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1246995015472 active site 1246995015473 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1246995015474 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1246995015475 active site 1246995015476 ATP binding site [chemical binding]; other site 1246995015477 substrate binding site [chemical binding]; other site 1246995015478 activation loop (A-loop); other site 1246995015479 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1246995015480 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1246995015481 putative sugar binding sites [chemical binding]; other site 1246995015482 Q-X-W motif; other site 1246995015483 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1246995015484 DNA-binding site [nucleotide binding]; DNA binding site 1246995015485 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1246995015486 active site 1246995015487 catalytic triad [active] 1246995015488 oxyanion hole [active] 1246995015489 Glycosyl hydrolase family 43; Region: GH43_4; cd08983 1246995015490 active site 1246995015491 Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270 1246995015492 Beta-lactamase; Region: Beta-lactamase; pfam00144 1246995015493 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1246995015494 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1246995015495 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1246995015496 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1246995015497 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 1246995015498 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1246995015499 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1246995015500 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1246995015501 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 1246995015502 Methyltransferase domain; Region: Methyltransf_24; pfam13578 1246995015503 Beta-lactamase; Region: Beta-lactamase; pfam00144 1246995015504 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1246995015505 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1246995015506 salt bridge; other site 1246995015507 non-specific DNA binding site [nucleotide binding]; other site 1246995015508 sequence-specific DNA binding site [nucleotide binding]; other site 1246995015509 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 1246995015510 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995015511 NAD(P) binding site [chemical binding]; other site 1246995015512 active site 1246995015513 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1246995015514 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1246995015515 active site 1246995015516 ATP binding site [chemical binding]; other site 1246995015517 substrate binding site [chemical binding]; other site 1246995015518 activation loop (A-loop); other site 1246995015519 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1246995015520 Selenocysteine-specific translation elongation factor [Translation, ribosomal structure and biogenesis]; Region: SelB; COG3276 1246995015521 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 1246995015522 G1 box; other site 1246995015523 putative GEF interaction site [polypeptide binding]; other site 1246995015524 GTP/Mg2+ binding site [chemical binding]; other site 1246995015525 Switch I region; other site 1246995015526 G2 box; other site 1246995015527 G3 box; other site 1246995015528 Switch II region; other site 1246995015529 G4 box; other site 1246995015530 G5 box; other site 1246995015531 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 1246995015532 Domain III of Elongation factor (EF) Tu (EF-TU) and EF-G. Elongation factors (EF) EF-Tu and EF-G participate in the elongation phase during protein biosynthesis on the ribosome. Their functional cycles depend on GTP binding and its hydrolysis. The EF-Tu...; Region: Translation_factor_III; cl02786 1246995015533 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 1246995015534 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 1246995015535 selenocysteine synthase; Provisional; Region: PRK04311 1246995015536 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1246995015537 selenium donor protein; Region: selD; TIGR00476 1246995015538 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 1246995015539 dimerization interface [polypeptide binding]; other site 1246995015540 ATP binding site [chemical binding]; other site 1246995015541 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 1246995015542 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 1246995015543 4Fe-4S binding domain; Region: Fer4; pfam00037 1246995015544 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1246995015545 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1246995015546 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1246995015547 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1246995015548 molybdopterin cofactor binding site; other site 1246995015549 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1246995015550 GAF domain; Region: GAF; pfam01590 1246995015551 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1246995015552 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1246995015553 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1246995015554 acyl-CoA synthetase; Validated; Region: PRK07787 1246995015555 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1246995015556 acyl-activating enzyme (AAE) consensus motif; other site 1246995015557 AMP binding site [chemical binding]; other site 1246995015558 active site 1246995015559 CoA binding site [chemical binding]; other site 1246995015560 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1246995015561 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1246995015562 Cytochrome P450; Region: p450; cl12078 1246995015563 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cd00110 1246995015564 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 1246995015565 Mrr N-terminal domain; Region: Mrr_N; pfam14338 1246995015566 Restriction endonuclease; Region: Mrr_cat; pfam04471 1246995015567 hypothetical protein; Provisional; Region: PRK06753 1246995015568 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1246995015569 methylenetetrahydromethanopterin reductase; Provisional; Region: PRK02271 1246995015570 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 1246995015571 PAS domain S-box; Region: sensory_box; TIGR00229 1246995015572 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1246995015573 putative active site [active] 1246995015574 heme pocket [chemical binding]; other site 1246995015575 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1246995015576 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1246995015577 metal binding site [ion binding]; metal-binding site 1246995015578 active site 1246995015579 I-site; other site 1246995015580 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1246995015581 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1246995015582 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 1246995015583 Strictosidine synthase; Region: Str_synth; pfam03088 1246995015584 Beta-lactamase; Region: Beta-lactamase; pfam00144 1246995015585 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1246995015586 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1246995015587 Secretory lipase; Region: LIP; pfam03583 1246995015588 Protein of unknown function (DUF1684); Region: DUF1684; pfam07920 1246995015589 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1246995015590 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1246995015591 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 1246995015592 active site 1246995015593 Zn binding site [ion binding]; other site 1246995015594 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1246995015595 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1246995015596 Nitrate and nitrite sensing; Region: NIT; pfam08376 1246995015597 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1246995015598 HAMP domain; Region: HAMP; pfam00672 1246995015599 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995015600 ATP binding site [chemical binding]; other site 1246995015601 Mg2+ binding site [ion binding]; other site 1246995015602 G-X-G motif; other site 1246995015603 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 1246995015604 Protein of unknown function (DUF742); Region: DUF742; pfam05331 1246995015605 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1246995015606 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1246995015607 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1246995015608 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1246995015609 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1246995015610 metal binding site [ion binding]; metal-binding site 1246995015611 active site 1246995015612 I-site; other site 1246995015613 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1246995015614 Protein of unknown function (DUF805); Region: DUF805; pfam05656 1246995015615 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1246995015616 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1246995015617 active site 1246995015618 ATP binding site [chemical binding]; other site 1246995015619 substrate binding site [chemical binding]; other site 1246995015620 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1246995015621 activation loop (A-loop); other site 1246995015622 activation loop (A-loop); other site 1246995015623 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1246995015624 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1246995015625 Protein of unknown function DUF58; Region: DUF58; pfam01882 1246995015626 MoxR-like ATPases [General function prediction only]; Region: COG0714 1246995015627 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1246995015628 Walker A motif; other site 1246995015629 ATP binding site [chemical binding]; other site 1246995015630 Walker B motif; other site 1246995015631 arginine finger; other site 1246995015632 Interdomain contacts; other site 1246995015633 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 1246995015634 Cytokine receptor motif; other site 1246995015635 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1246995015636 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1246995015637 dimer interface [polypeptide binding]; other site 1246995015638 phosphorylation site [posttranslational modification] 1246995015639 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995015640 ATP binding site [chemical binding]; other site 1246995015641 Mg2+ binding site [ion binding]; other site 1246995015642 G-X-G motif; other site 1246995015643 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1246995015644 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995015645 active site 1246995015646 phosphorylation site [posttranslational modification] 1246995015647 intermolecular recognition site; other site 1246995015648 dimerization interface [polypeptide binding]; other site 1246995015649 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1246995015650 DNA binding site [nucleotide binding] 1246995015651 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 1246995015652 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 1246995015653 AAA ATPase domain; Region: AAA_16; pfam13191 1246995015654 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1246995015655 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1246995015656 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995015657 active site 1246995015658 phosphorylation site [posttranslational modification] 1246995015659 intermolecular recognition site; other site 1246995015660 dimerization interface [polypeptide binding]; other site 1246995015661 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1246995015662 DNA binding site [nucleotide binding] 1246995015663 Predicted transcriptional regulators [Transcription]; Region: COG1733 1246995015664 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1246995015665 Protein of unknown function (DUF419); Region: DUF419; cl15265 1246995015666 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 1246995015667 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1246995015668 Interdomain contacts; other site 1246995015669 Cytokine receptor motif; other site 1246995015670 Cellulose binding domain; Region: CBM_2; pfam00553 1246995015671 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 1246995015672 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995015673 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1246995015674 DNA binding residues [nucleotide binding] 1246995015675 Predicted integral membrane proteins containing uncharacterized repeats [Function unknown]; Region: COG5563 1246995015676 Uncharacterized conserved protein [Function unknown]; Region: COG0397 1246995015677 hypothetical protein; Validated; Region: PRK00029 1246995015678 hypothetical protein; Validated; Region: PRK00029 1246995015679 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 1246995015680 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1246995015681 Trp docking motif [polypeptide binding]; other site 1246995015682 active site 1246995015683 PQQ-like domain; Region: PQQ_2; pfam13360 1246995015684 Lens epithelium-derived growth factor (LEDGF); Region: LEDGF; pfam11467 1246995015685 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1246995015686 sugar efflux transporter; Region: 2A0120; TIGR00899 1246995015687 putative substrate translocation pore; other site 1246995015688 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 1246995015689 active site 1246995015690 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 1246995015691 aromatic chitin/cellulose binding site residues [chemical binding]; other site 1246995015692 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 1246995015693 aromatic chitin/cellulose binding site residues [chemical binding]; other site 1246995015694 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1246995015695 active site 1246995015696 Catechol dioxygenase N terminus; Region: Dioxygenase_N; pfam04444 1246995015697 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 1246995015698 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 1246995015699 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1246995015700 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995015701 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995015702 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1246995015703 Beta-lactamase; Region: Beta-lactamase; pfam00144 1246995015704 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1246995015705 Coenzyme A binding pocket [chemical binding]; other site 1246995015706 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1246995015707 AAA ATPase domain; Region: AAA_16; pfam13191 1246995015708 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995015709 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995015710 DNA binding residues [nucleotide binding] 1246995015711 dimerization interface [polypeptide binding]; other site 1246995015712 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1246995015713 anti sigma factor interaction site; other site 1246995015714 regulatory phosphorylation site [posttranslational modification]; other site 1246995015715 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1246995015716 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1246995015717 NAD(P) binding site [chemical binding]; other site 1246995015718 catalytic residues [active] 1246995015719 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1246995015720 Cytochrome P450; Region: p450; cl12078 1246995015721 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1246995015722 anti sigma factor interaction site; other site 1246995015723 regulatory phosphorylation site [posttranslational modification]; other site 1246995015724 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1246995015725 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1246995015726 active site 1246995015727 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 1246995015728 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1246995015729 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1246995015730 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1246995015731 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1246995015732 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1246995015733 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1246995015734 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1246995015735 carboxyltransferase (CT) interaction site; other site 1246995015736 biotinylation site [posttranslational modification]; other site 1246995015737 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995015738 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995015739 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 1246995015740 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1246995015741 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1246995015742 Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025 1246995015743 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1246995015744 Sulfatase; Region: Sulfatase; pfam00884 1246995015745 PRC-barrel domain; Region: PRC; pfam05239 1246995015746 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1246995015747 hydrophobic ligand binding site; other site 1246995015748 Predicted acyl esterases [General function prediction only]; Region: COG2936 1246995015749 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 1246995015750 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 1246995015751 putative metal binding site [ion binding]; other site 1246995015752 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 1246995015753 putative metal binding site [ion binding]; other site 1246995015754 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 1246995015755 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 1246995015756 active site 1246995015757 catalytic site [active] 1246995015758 Immunity protein Imm1; Region: Imm1; pfam14430 1246995015759 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 1246995015760 SnoaL-like domain; Region: SnoaL_3; pfam13474 1246995015761 RNA polymerase factor sigma-70; Validated; Region: PRK08241 1246995015762 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995015763 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1246995015764 DNA binding residues [nucleotide binding] 1246995015765 SnoaL-like domain; Region: SnoaL_2; pfam12680 1246995015766 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 1246995015767 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1246995015768 substrate binding site [chemical binding]; other site 1246995015769 activation loop (A-loop); other site 1246995015770 AAA ATPase domain; Region: AAA_16; pfam13191 1246995015771 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1246995015772 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1246995015773 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1246995015774 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1246995015775 metal binding site [ion binding]; metal-binding site 1246995015776 active site 1246995015777 I-site; other site 1246995015778 Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566 1246995015779 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1246995015780 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1246995015781 putative sugar binding sites [chemical binding]; other site 1246995015782 Q-X-W motif; other site 1246995015783 Ricin-type beta-trefoil; Region: RICIN; smart00458 1246995015784 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1246995015785 putative sugar binding sites [chemical binding]; other site 1246995015786 Q-X-W motif; other site 1246995015787 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1246995015788 Interdomain contacts; other site 1246995015789 Cytokine receptor motif; other site 1246995015790 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1246995015791 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1246995015792 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1246995015793 dimerization interface [polypeptide binding]; other site 1246995015794 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1246995015795 dimer interface [polypeptide binding]; other site 1246995015796 phosphorylation site [posttranslational modification] 1246995015797 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995015798 ATP binding site [chemical binding]; other site 1246995015799 Mg2+ binding site [ion binding]; other site 1246995015800 G-X-G motif; other site 1246995015801 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1246995015802 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995015803 active site 1246995015804 phosphorylation site [posttranslational modification] 1246995015805 intermolecular recognition site; other site 1246995015806 dimerization interface [polypeptide binding]; other site 1246995015807 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1246995015808 DNA binding site [nucleotide binding] 1246995015809 cleavage site 1246995015810 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1246995015811 active site 1246995015812 substrate binding sites [chemical binding]; other site 1246995015813 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1246995015814 dimerization interface [polypeptide binding]; other site 1246995015815 putative DNA binding site [nucleotide binding]; other site 1246995015816 putative Zn2+ binding site [ion binding]; other site 1246995015817 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_9; cd07826 1246995015818 putative hydrophobic ligand binding site [chemical binding]; other site 1246995015819 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1246995015820 RibD C-terminal domain; Region: RibD_C; cl17279 1246995015821 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 1246995015822 putative FMN binding site [chemical binding]; other site 1246995015823 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1246995015824 Transglutaminase-like superfamily; Region: Transglut_core; cl17362 1246995015825 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1246995015826 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1246995015827 putative NAD(P) binding site [chemical binding]; other site 1246995015828 Cupin domain; Region: Cupin_2; pfam07883 1246995015829 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1246995015830 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1246995015831 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995015832 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995015833 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1246995015834 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 1246995015835 active site 1246995015836 DNA binding site [nucleotide binding] 1246995015837 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 1246995015838 DNA binding site [nucleotide binding] 1246995015839 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 1246995015840 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995015841 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1246995015842 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1246995015843 catalytic site [active] 1246995015844 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1246995015845 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1246995015846 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1246995015847 FtsX-like permease family; Region: FtsX; pfam02687 1246995015848 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1246995015849 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1246995015850 Walker A/P-loop; other site 1246995015851 ATP binding site [chemical binding]; other site 1246995015852 Q-loop/lid; other site 1246995015853 ABC transporter signature motif; other site 1246995015854 Walker B; other site 1246995015855 D-loop; other site 1246995015856 H-loop/switch region; other site 1246995015857 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1246995015858 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1246995015859 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995015860 active site 1246995015861 phosphorylation site [posttranslational modification] 1246995015862 intermolecular recognition site; other site 1246995015863 dimerization interface [polypeptide binding]; other site 1246995015864 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1246995015865 DNA binding site [nucleotide binding] 1246995015866 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1246995015867 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1246995015868 dimer interface [polypeptide binding]; other site 1246995015869 phosphorylation site [posttranslational modification] 1246995015870 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995015871 ATP binding site [chemical binding]; other site 1246995015872 Mg2+ binding site [ion binding]; other site 1246995015873 G-X-G motif; other site 1246995015874 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1246995015875 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1246995015876 dimer interface [polypeptide binding]; other site 1246995015877 phosphorylation site [posttranslational modification] 1246995015878 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995015879 ATP binding site [chemical binding]; other site 1246995015880 Mg2+ binding site [ion binding]; other site 1246995015881 G-X-G motif; other site 1246995015882 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1246995015883 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995015884 active site 1246995015885 phosphorylation site [posttranslational modification] 1246995015886 intermolecular recognition site; other site 1246995015887 dimerization interface [polypeptide binding]; other site 1246995015888 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1246995015889 DNA binding site [nucleotide binding] 1246995015890 Mannosyltransferase (PIG-V)); Region: Mannosyl_trans2; pfam04188 1246995015891 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1246995015892 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1246995015893 Ligand binding site; other site 1246995015894 Putative Catalytic site; other site 1246995015895 DXD motif; other site 1246995015896 Helix-turn-helix domain; Region: HTH_17; cl17695 1246995015897 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 1246995015898 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1246995015899 catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211 1246995015900 active site 1246995015901 metal binding site [ion binding]; metal-binding site 1246995015902 C-terminal domain of catechol 2,3-dioxygenase; Region: 2_3_CTD_C; cd07243 1246995015903 tetramer interface [polypeptide binding]; other site 1246995015904 active site 1246995015905 Fe binding site [ion binding]; other site 1246995015906 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1246995015907 catalytic loop [active] 1246995015908 iron binding site [ion binding]; other site 1246995015909 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 1246995015910 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1246995015911 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1246995015912 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 1246995015913 DNA-binding site [nucleotide binding]; DNA binding site 1246995015914 FCD domain; Region: FCD; pfam07729 1246995015915 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 1246995015916 LabA_like proteins; Region: LabA_like; cd06167 1246995015917 putative metal binding site [ion binding]; other site 1246995015918 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1246995015919 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1246995015920 PAS domain S-box; Region: sensory_box; TIGR00229 1246995015921 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1246995015922 putative active site [active] 1246995015923 heme pocket [chemical binding]; other site 1246995015924 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1246995015925 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1246995015926 putative active site [active] 1246995015927 heme pocket [chemical binding]; other site 1246995015928 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1246995015929 dimer interface [polypeptide binding]; other site 1246995015930 phosphorylation site [posttranslational modification] 1246995015931 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995015932 ATP binding site [chemical binding]; other site 1246995015933 Mg2+ binding site [ion binding]; other site 1246995015934 G-X-G motif; other site 1246995015935 Response regulator receiver domain; Region: Response_reg; pfam00072 1246995015936 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995015937 active site 1246995015938 phosphorylation site [posttranslational modification] 1246995015939 intermolecular recognition site; other site 1246995015940 dimerization interface [polypeptide binding]; other site 1246995015941 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1246995015942 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1246995015943 putative active site [active] 1246995015944 putative metal binding site [ion binding]; other site 1246995015945 short chain dehydrogenase; Provisional; Region: PRK06180 1246995015946 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1246995015947 NADP binding site [chemical binding]; other site 1246995015948 active site 1246995015949 steroid binding site; other site 1246995015950 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1246995015951 salt bridge; other site 1246995015952 non-specific DNA binding site [nucleotide binding]; other site 1246995015953 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1246995015954 sequence-specific DNA binding site [nucleotide binding]; other site 1246995015955 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1246995015956 putative DNA binding site [nucleotide binding]; other site 1246995015957 EVE domain; Region: EVE; cl00728 1246995015958 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1246995015959 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1246995015960 NAD binding site [chemical binding]; other site 1246995015961 catalytic Zn binding site [ion binding]; other site 1246995015962 structural Zn binding site [ion binding]; other site 1246995015963 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1246995015964 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1246995015965 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1246995015966 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1246995015967 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995015968 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995015969 active site 1246995015970 phosphorylation site [posttranslational modification] 1246995015971 intermolecular recognition site; other site 1246995015972 dimerization interface [polypeptide binding]; other site 1246995015973 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995015974 DNA binding residues [nucleotide binding] 1246995015975 dimerization interface [polypeptide binding]; other site 1246995015976 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1246995015977 Histidine kinase; Region: HisKA_3; pfam07730 1246995015978 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1246995015979 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1246995015980 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1246995015981 active site 1246995015982 ATP binding site [chemical binding]; other site 1246995015983 substrate binding site [chemical binding]; other site 1246995015984 activation loop (A-loop); other site 1246995015985 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1246995015986 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995015987 dimerization interface [polypeptide binding]; other site 1246995015988 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995015989 DNA binding residues [nucleotide binding] 1246995015990 dimerization interface [polypeptide binding]; other site 1246995015991 TAP-like protein; Region: Abhydrolase_4; pfam08386 1246995015992 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1246995015993 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 1246995015994 Walker A/P-loop; other site 1246995015995 ATP binding site [chemical binding]; other site 1246995015996 Q-loop/lid; other site 1246995015997 ABC transporter signature motif; other site 1246995015998 Walker B; other site 1246995015999 D-loop; other site 1246995016000 H-loop/switch region; other site 1246995016001 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1246995016002 Histidine kinase; Region: HisKA_3; pfam07730 1246995016003 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995016004 Mg2+ binding site [ion binding]; other site 1246995016005 G-X-G motif; other site 1246995016006 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995016007 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995016008 active site 1246995016009 phosphorylation site [posttranslational modification] 1246995016010 intermolecular recognition site; other site 1246995016011 dimerization interface [polypeptide binding]; other site 1246995016012 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995016013 DNA binding residues [nucleotide binding] 1246995016014 dimerization interface [polypeptide binding]; other site 1246995016015 mercuric resistence transcriptional repressor protein MerD; Region: MerD; TIGR02054 1246995016016 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1246995016017 DNA binding residues [nucleotide binding] 1246995016018 dimer interface [polypeptide binding]; other site 1246995016019 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 1246995016020 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1246995016021 Serine hydrolase; Region: Ser_hydrolase; cl17834 1246995016022 MarR family; Region: MarR_2; cl17246 1246995016023 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1246995016024 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1246995016025 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1246995016026 TAP-like protein; Region: Abhydrolase_4; pfam08386 1246995016027 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1246995016028 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1246995016029 Walker A/P-loop; other site 1246995016030 ATP binding site [chemical binding]; other site 1246995016031 Q-loop/lid; other site 1246995016032 ABC transporter signature motif; other site 1246995016033 Walker B; other site 1246995016034 D-loop; other site 1246995016035 H-loop/switch region; other site 1246995016036 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 1246995016037 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1246995016038 putative NAD(P) binding site [chemical binding]; other site 1246995016039 Predicted acetyltransferase [General function prediction only]; Region: COG2388 1246995016040 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1246995016041 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1246995016042 MarR family; Region: MarR_2; pfam12802 1246995016043 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1246995016044 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1246995016045 DNA binding residues [nucleotide binding] 1246995016046 dimer interface [polypeptide binding]; other site 1246995016047 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995016048 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1246995016049 NAD(P) binding site [chemical binding]; other site 1246995016050 active site 1246995016051 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995016052 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995016053 AAA ATPase domain; Region: AAA_16; pfam13191 1246995016054 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995016055 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995016056 DNA binding residues [nucleotide binding] 1246995016057 dimerization interface [polypeptide binding]; other site 1246995016058 Phenazine biosynthesis-like protein; Region: PhzC-PhzF; pfam02567 1246995016059 CAAX protease self-immunity; Region: Abi; pfam02517 1246995016060 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1246995016061 TAP-like protein; Region: Abhydrolase_4; pfam08386 1246995016062 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1246995016063 GAF domain; Region: GAF; pfam01590 1246995016064 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1246995016065 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1246995016066 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1246995016067 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1246995016068 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1246995016069 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1246995016070 GAF domain; Region: GAF; cl17456 1246995016071 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1246995016072 Histidine kinase; Region: HisKA_3; pfam07730 1246995016073 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1246995016074 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995016075 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995016076 active site 1246995016077 phosphorylation site [posttranslational modification] 1246995016078 intermolecular recognition site; other site 1246995016079 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995016080 DNA binding residues [nucleotide binding] 1246995016081 dimerization interface [polypeptide binding]; other site 1246995016082 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995016083 active site 1246995016084 phosphorylation site [posttranslational modification] 1246995016085 intermolecular recognition site; other site 1246995016086 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1246995016087 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1246995016088 Cupin domain; Region: Cupin_2; pfam07883 1246995016089 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1246995016090 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 1246995016091 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1246995016092 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT; cl04176 1246995016093 gating phenylalanine in ion channel; other site 1246995016094 oxidoreductase; Provisional; Region: PRK06196 1246995016095 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1246995016096 putative NAD(P) binding site [chemical binding]; other site 1246995016097 active site 1246995016098 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1246995016099 Epoxide hydrolase N terminus; Region: EHN; pfam06441 1246995016100 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1246995016101 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1246995016102 MarR family; Region: MarR_2; cl17246 1246995016103 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 1246995016104 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1246995016105 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1246995016106 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1246995016107 binding surface 1246995016108 TPR motif; other site 1246995016109 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1246995016110 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1246995016111 GAF domain; Region: GAF; pfam01590 1246995016112 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1246995016113 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1246995016114 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1246995016115 dimer interface [polypeptide binding]; other site 1246995016116 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1246995016117 putative CheW interface [polypeptide binding]; other site 1246995016118 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1246995016119 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1246995016120 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1246995016121 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1246995016122 active site 1246995016123 ATP binding site [chemical binding]; other site 1246995016124 substrate binding site [chemical binding]; other site 1246995016125 activation loop (A-loop); other site 1246995016126 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1246995016127 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1246995016128 active site 1246995016129 ATP binding site [chemical binding]; other site 1246995016130 substrate binding site [chemical binding]; other site 1246995016131 activation loop (A-loop); other site 1246995016132 Carbohydrate Binding Module 6 (CBM6); appended to glycoside hydrolase (GH) domains, including GH5 (cellulase); Region: CBM6_cellulase-like; cd04080 1246995016133 Ca binding site [ion binding]; other site 1246995016134 ligand binding site I [chemical binding]; other site 1246995016135 homodimer interface [polypeptide binding]; other site 1246995016136 ligand binding site II [chemical binding]; other site 1246995016137 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 1246995016138 pyridoxamine kinase; Validated; Region: PRK05756 1246995016139 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1246995016140 dimer interface [polypeptide binding]; other site 1246995016141 pyridoxal binding site [chemical binding]; other site 1246995016142 ATP binding site [chemical binding]; other site 1246995016143 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1246995016144 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1246995016145 DNA-binding site [nucleotide binding]; DNA binding site 1246995016146 FCD domain; Region: FCD; pfam07729 1246995016147 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1246995016148 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1246995016149 active site 1246995016150 catalytic tetrad [active] 1246995016151 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 1246995016152 Amidohydrolase; Region: Amidohydro_2; pfam04909 1246995016153 Domain of unknown function (DUF718); Region: DUF718; pfam05336 1246995016154 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 1246995016155 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1246995016156 active site pocket [active] 1246995016157 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1246995016158 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995016159 dimer interface [polypeptide binding]; other site 1246995016160 conserved gate region; other site 1246995016161 putative PBP binding loops; other site 1246995016162 ABC-ATPase subunit interface; other site 1246995016163 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 1246995016164 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1246995016165 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1246995016166 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1246995016167 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1246995016168 NAD(P) binding site [chemical binding]; other site 1246995016169 2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832 1246995016170 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995016171 NAD(P) binding site [chemical binding]; other site 1246995016172 active site 1246995016173 Predicted transcriptional regulators [Transcription]; Region: COG1733 1246995016174 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1246995016175 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 1246995016176 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1246995016177 putative alcohol dehydrogenase; Provisional; Region: PRK13771 1246995016178 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1246995016179 NAD(P) binding site [chemical binding]; other site 1246995016180 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 1246995016181 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1246995016182 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1246995016183 Cupin; Region: Cupin_6; pfam12852 1246995016184 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1246995016185 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1246995016186 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1246995016187 Glycosyl hydrolase family 59; Region: Glyco_hydro_59; pfam02057 1246995016188 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1246995016189 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1246995016190 putative sugar binding sites [chemical binding]; other site 1246995016191 Q-X-W motif; other site 1246995016192 alpha-galactosidase; Region: PLN02808; cl17638 1246995016193 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1246995016194 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1246995016195 putative sugar binding sites [chemical binding]; other site 1246995016196 Q-X-W motif; other site 1246995016197 SGNH_hydrolase subfamily, similar to Ruminococcus flavefaciens XynB. Most likely a secreted hydrolase with xylanase activity. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from...; Region: XynB_like; cd01833 1246995016198 active site 1246995016199 catalytic triad [active] 1246995016200 oxyanion hole [active] 1246995016201 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1246995016202 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1246995016203 putative sugar binding sites [chemical binding]; other site 1246995016204 Q-X-W motif; other site 1246995016205 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 1246995016206 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 1246995016207 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1246995016208 putative sugar binding sites [chemical binding]; other site 1246995016209 Q-X-W motif; other site 1246995016210 Right handed beta helix region; Region: Beta_helix; pfam13229 1246995016211 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1246995016212 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1246995016213 putative sugar binding sites [chemical binding]; other site 1246995016214 Q-X-W motif; other site 1246995016215 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 1246995016216 substrate binding site [chemical binding]; other site 1246995016217 active site 1246995016218 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 1246995016219 metal binding site [ion binding]; metal-binding site 1246995016220 ligand binding site [chemical binding]; other site 1246995016221 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 1246995016222 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1246995016223 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1246995016224 putative sugar binding sites [chemical binding]; other site 1246995016225 Q-X-W motif; other site 1246995016226 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 1246995016227 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1246995016228 active site 1246995016229 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1246995016230 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1246995016231 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1246995016232 putative sugar binding sites [chemical binding]; other site 1246995016233 Q-X-W motif; other site 1246995016234 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1246995016235 FOG: PKD repeat [General function prediction only]; Region: COG3291 1246995016236 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 1246995016237 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 1246995016238 metal binding site [ion binding]; metal-binding site 1246995016239 ligand binding site [chemical binding]; other site 1246995016240 Ricin-type beta-trefoil; Region: RICIN; smart00458 1246995016241 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1246995016242 putative sugar binding sites [chemical binding]; other site 1246995016243 Q-X-W motif; other site 1246995016244 Trehalose utilisation; Region: ThuA; pfam06283 1246995016245 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 1246995016246 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1246995016247 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1246995016248 putative sugar binding sites [chemical binding]; other site 1246995016249 Q-X-W motif; other site 1246995016250 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1246995016251 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1246995016252 putative sugar binding sites [chemical binding]; other site 1246995016253 Q-X-W motif; other site 1246995016254 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1246995016255 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1246995016256 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1246995016257 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995016258 Walker A/P-loop; other site 1246995016259 ATP binding site [chemical binding]; other site 1246995016260 Q-loop/lid; other site 1246995016261 ABC transporter signature motif; other site 1246995016262 Walker B; other site 1246995016263 D-loop; other site 1246995016264 H-loop/switch region; other site 1246995016265 MbtH-like protein; Region: MbtH; cl01279 1246995016266 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1246995016267 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1246995016268 acyl-activating enzyme (AAE) consensus motif; other site 1246995016269 AMP binding site [chemical binding]; other site 1246995016270 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1246995016271 Condensation domain; Region: Condensation; pfam00668 1246995016272 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1246995016273 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1246995016274 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1246995016275 acyl-activating enzyme (AAE) consensus motif; other site 1246995016276 AMP binding site [chemical binding]; other site 1246995016277 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1246995016278 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1246995016279 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1246995016280 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1246995016281 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1246995016282 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1246995016283 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1246995016284 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1246995016285 active site 1246995016286 metal binding site [ion binding]; metal-binding site 1246995016287 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1246995016288 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1246995016289 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1246995016290 dimerization interface [polypeptide binding]; other site 1246995016291 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1246995016292 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1246995016293 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1246995016294 dimerization interface [polypeptide binding]; other site 1246995016295 short chain dehydrogenase; Provisional; Region: PRK09291 1246995016296 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995016297 NAD(P) binding site [chemical binding]; other site 1246995016298 active site 1246995016299 malate dehydrogenase; Provisional; Region: PRK13529 1246995016300 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1246995016301 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1246995016302 NAD(P) binding site [chemical binding]; other site 1246995016303 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1246995016304 Class II fumarases; Region: Fumarase_classII; cd01362 1246995016305 active site 1246995016306 tetramer interface [polypeptide binding]; other site 1246995016307 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 1246995016308 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1246995016309 potential catalytic triad [active] 1246995016310 conserved cys residue [active] 1246995016311 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1246995016312 Amidase; Region: Amidase; pfam01425 1246995016313 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995016314 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1246995016315 NAD(P) binding site [chemical binding]; other site 1246995016316 active site 1246995016317 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995016318 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1246995016319 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1246995016320 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1246995016321 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1246995016322 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1246995016323 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1246995016324 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1246995016325 cyanate transporter; Region: CynX; TIGR00896 1246995016326 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 1246995016327 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995016328 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995016329 SnoaL-like domain; Region: SnoaL_2; pfam12680 1246995016330 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1246995016331 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995016332 WHG domain; Region: WHG; pfam13305 1246995016333 hypothetical protein; Provisional; Region: PRK06184 1246995016334 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1246995016335 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1246995016336 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1246995016337 Probable transposase; Region: OrfB_IS605; pfam01385 1246995016338 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1246995016339 Transposase IS200 like; Region: Y1_Tnp; cl00848 1246995016340 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1246995016341 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 1246995016342 Amidohydrolase; Region: Amidohydro_2; pfam04909 1246995016343 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 1246995016344 classical (c) SDRs; Region: SDR_c; cd05233 1246995016345 NAD(P) binding site [chemical binding]; other site 1246995016346 active site 1246995016347 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1246995016348 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1246995016349 FtsX-like permease family; Region: FtsX; pfam02687 1246995016350 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1246995016351 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 1246995016352 Walker A/P-loop; other site 1246995016353 ATP binding site [chemical binding]; other site 1246995016354 Q-loop/lid; other site 1246995016355 ABC transporter signature motif; other site 1246995016356 Walker B; other site 1246995016357 D-loop; other site 1246995016358 H-loop/switch region; other site 1246995016359 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1246995016360 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995016361 active site 1246995016362 phosphorylation site [posttranslational modification] 1246995016363 intermolecular recognition site; other site 1246995016364 dimerization interface [polypeptide binding]; other site 1246995016365 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1246995016366 DNA binding site [nucleotide binding] 1246995016367 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1246995016368 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1246995016369 dimer interface [polypeptide binding]; other site 1246995016370 phosphorylation site [posttranslational modification] 1246995016371 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995016372 Mg2+ binding site [ion binding]; other site 1246995016373 G-X-G motif; other site 1246995016374 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 1246995016375 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1246995016376 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1246995016377 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 1246995016378 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 1246995016379 FAD binding pocket [chemical binding]; other site 1246995016380 FAD binding motif [chemical binding]; other site 1246995016381 phosphate binding motif [ion binding]; other site 1246995016382 beta-alpha-beta structure motif; other site 1246995016383 NAD(p) ribose binding residues [chemical binding]; other site 1246995016384 NAD binding pocket [chemical binding]; other site 1246995016385 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 1246995016386 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1246995016387 catalytic loop [active] 1246995016388 iron binding site [ion binding]; other site 1246995016389 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995016390 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995016391 SnoaL-like domain; Region: SnoaL_4; pfam13577 1246995016392 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1246995016393 NB-ARC domain; Region: NB-ARC; pfam00931 1246995016394 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 1246995016395 FAD binding domain; Region: FAD_binding_4; pfam01565 1246995016396 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1246995016397 Berberine and berberine like; Region: BBE; pfam08031 1246995016398 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 1246995016399 MarR family; Region: MarR_2; pfam12802 1246995016400 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995016401 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995016402 short chain dehydrogenase; Provisional; Region: PRK06500 1246995016403 classical (c) SDRs; Region: SDR_c; cd05233 1246995016404 NAD(P) binding site [chemical binding]; other site 1246995016405 active site 1246995016406 Pirin-related protein [General function prediction only]; Region: COG1741 1246995016407 Pirin; Region: Pirin; pfam02678 1246995016408 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1246995016409 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 1246995016410 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1246995016411 sugar binding site [chemical binding]; other site 1246995016412 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 1246995016413 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1246995016414 active site 1246995016415 Transmembrane secretion effector; Region: MFS_3; pfam05977 1246995016416 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1246995016417 putative substrate translocation pore; other site 1246995016418 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1246995016419 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1246995016420 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1246995016421 DNA binding site [nucleotide binding] 1246995016422 active site 1246995016423 Int/Topo IB signature motif; other site 1246995016424 AIPR protein; Region: AIPR; pfam10592 1246995016425 AAA ATPase domain; Region: AAA_16; pfam13191 1246995016426 Domain of unknown function DUF87; Region: DUF87; pfam01935 1246995016427 AAA-like domain; Region: AAA_10; pfam12846 1246995016428 Zonular occludens toxin (Zot); Region: Zot; cl17485 1246995016429 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 1246995016430 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995016431 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1246995016432 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1246995016433 PLD-like domain; Region: PLDc_2; pfam13091 1246995016434 putative active site [active] 1246995016435 catalytic site [active] 1246995016436 AAA domain; Region: AAA_11; pfam13086 1246995016437 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1246995016438 Walker A motif; other site 1246995016439 ATP binding site [chemical binding]; other site 1246995016440 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 1246995016441 AAA domain; Region: AAA_12; pfam13087 1246995016442 CRISPR-associated protein (Cas_Cas02710); Region: Cas_Cas02710; pfam09670 1246995016443 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl11817 1246995016444 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 1246995016445 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1246995016446 ATP binding site [chemical binding]; other site 1246995016447 putative Mg++ binding site [ion binding]; other site 1246995016448 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1246995016449 nucleotide binding region [chemical binding]; other site 1246995016450 ATP-binding site [chemical binding]; other site 1246995016451 P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923 1246995016452 PglZ domain; Region: PglZ; pfam08665 1246995016453 Protein of unknown function (DUF499); Region: DUF499; pfam04465 1246995016454 Uncharacterized conserved protein [Function unknown]; Region: COG1479 1246995016455 Protein of unknown function DUF262; Region: DUF262; pfam03235 1246995016456 Uncharacterized conserved protein [Function unknown]; Region: COG3472 1246995016457 Uncharacterized conserved protein [Function unknown]; Region: COG4127 1246995016458 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 1246995016459 Nuclease-related domain; Region: NERD; pfam08378 1246995016460 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1246995016461 active site 1246995016462 ATP binding site [chemical binding]; other site 1246995016463 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1246995016464 Protein kinase domain; Region: Pkinase; pfam00069 1246995016465 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1246995016466 active site 1246995016467 ATP binding site [chemical binding]; other site 1246995016468 substrate binding site [chemical binding]; other site 1246995016469 activation loop (A-loop); other site 1246995016470 ribosome-associated GTPase EngA; Region: GTPase_EngA; TIGR03594 1246995016471 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1246995016472 GTP/Mg2+ binding site [chemical binding]; other site 1246995016473 Switch I region; other site 1246995016474 G2 box; other site 1246995016475 Switch II region; other site 1246995016476 G3 box; other site 1246995016477 G4 box; other site 1246995016478 G5 box; other site 1246995016479 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1246995016480 G1 box; other site 1246995016481 GTP/Mg2+ binding site [chemical binding]; other site 1246995016482 Switch I region; other site 1246995016483 G2 box; other site 1246995016484 G3 box; other site 1246995016485 Switch II region; other site 1246995016486 G4 box; other site 1246995016487 G5 box; other site 1246995016488 cytidylate kinase; Provisional; Region: cmk; PRK00023 1246995016489 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1246995016490 CMP-binding site; other site 1246995016491 The sites determining sugar specificity; other site 1246995016492 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1246995016493 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1246995016494 RNA binding surface [nucleotide binding]; other site 1246995016495 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1246995016496 active site 1246995016497 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 1246995016498 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 1246995016499 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 1246995016500 Phosphotransferase enzyme family; Region: APH; pfam01636 1246995016501 active site 1246995016502 ATP binding site [chemical binding]; other site 1246995016503 antibiotic binding site [chemical binding]; other site 1246995016504 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1246995016505 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1246995016506 motif II; other site 1246995016507 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 1246995016508 Poxvirus rifampicin resistance protein; Region: Pox_Rif; pfam03340 1246995016509 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1246995016510 nudix motif; other site 1246995016511 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1246995016512 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 1246995016513 homodimer interface [polypeptide binding]; other site 1246995016514 substrate-cofactor binding pocket; other site 1246995016515 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1246995016516 catalytic residue [active] 1246995016517 HD domain; Region: HD_4; pfam13328 1246995016518 B12-binding domain/radical SAM domain protein, MJ_0865 family; Region: B12_SAM_MJ_0865; TIGR04014 1246995016519 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1246995016520 FOG: CBS domain [General function prediction only]; Region: COG0517 1246995016521 Divergent AAA domain; Region: AAA_4; pfam04326 1246995016522 Protein of unknown function (DUF2283); Region: DUF2283; pfam10049 1246995016523 DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684 1246995016524 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1246995016525 Zn binding sites [ion binding]; other site 1246995016526 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1246995016527 dimer interface [polypeptide binding]; other site 1246995016528 Protein of unknown function (DUF867); Region: DUF867; cl01713 1246995016529 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 1246995016530 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995016531 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995016532 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1246995016533 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1246995016534 NAD(P) binding site [chemical binding]; other site 1246995016535 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1246995016536 MarR family; Region: MarR; pfam01047 1246995016537 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995016538 NmrA-like family; Region: NmrA; pfam05368 1246995016539 NAD(P) binding site [chemical binding]; other site 1246995016540 active site 1246995016541 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995016542 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1246995016543 MarR family; Region: MarR; pfam01047 1246995016544 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1246995016545 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1246995016546 active site 1246995016547 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1246995016548 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1246995016549 minor groove reading motif; other site 1246995016550 helix-hairpin-helix signature motif; other site 1246995016551 substrate binding pocket [chemical binding]; other site 1246995016552 active site 1246995016553 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK13964 1246995016554 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1246995016555 active site 1246995016556 nucleotide binding site [chemical binding]; other site 1246995016557 HIGH motif; other site 1246995016558 KMSKS motif; other site 1246995016559 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 1246995016560 Domain of unknown function (DUF4259); Region: DUF4259; pfam14078 1246995016561 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1246995016562 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1246995016563 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1246995016564 Ligand binding site; other site 1246995016565 Putative Catalytic site; other site 1246995016566 DXD motif; other site 1246995016567 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cl00630 1246995016568 putative active site [active] 1246995016569 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1246995016570 putative substrate binding region [chemical binding]; other site 1246995016571 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1246995016572 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1246995016573 P-loop; other site 1246995016574 Magnesium ion binding site [ion binding]; other site 1246995016575 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1246995016576 Magnesium ion binding site [ion binding]; other site 1246995016577 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1246995016578 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1246995016579 active site 1246995016580 DNA binding site [nucleotide binding] 1246995016581 Int/Topo IB signature motif; other site 1246995016582 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1246995016583 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1246995016584 hexamer interface [polypeptide binding]; other site 1246995016585 ligand binding site [chemical binding]; other site 1246995016586 putative active site [active] 1246995016587 NAD(P) binding site [chemical binding]; other site 1246995016588 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1246995016589 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1246995016590 Probable transposase; Region: OrfB_IS605; pfam01385 1246995016591 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1246995016592 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1246995016593 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1246995016594 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 1246995016595 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1246995016596 dimer interface [polypeptide binding]; other site 1246995016597 ADP-ribose binding site [chemical binding]; other site 1246995016598 active site 1246995016599 nudix motif; other site 1246995016600 metal binding site [ion binding]; metal-binding site 1246995016601 CTP synthetase; Validated; Region: pyrG; PRK05380 1246995016602 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1246995016603 Catalytic site [active] 1246995016604 active site 1246995016605 UTP binding site [chemical binding]; other site 1246995016606 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1246995016607 active site 1246995016608 putative oxyanion hole; other site 1246995016609 catalytic triad [active] 1246995016610 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1246995016611 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1246995016612 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1246995016613 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 1246995016614 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 1246995016615 Thiamine pyrophosphokinase; Region: TPK; cl08415 1246995016616 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1246995016617 Probable transposase; Region: OrfB_IS605; pfam01385 1246995016618 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1246995016619 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1246995016620 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1246995016621 Walker A/P-loop; other site 1246995016622 ATP binding site [chemical binding]; other site 1246995016623 Q-loop/lid; other site 1246995016624 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1246995016625 ABC transporter signature motif; other site 1246995016626 Walker B; other site 1246995016627 D-loop; other site 1246995016628 H-loop/switch region; other site 1246995016629 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 1246995016630 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708 1246995016631 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1246995016632 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1246995016633 RNA binding surface [nucleotide binding]; other site 1246995016634 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1246995016635 S-adenosylmethionine binding site [chemical binding]; other site 1246995016636 Uncharacterized conserved protein [Function unknown]; Region: COG3937 1246995016637 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1246995016638 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1246995016639 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 1246995016640 Walker A/P-loop; other site 1246995016641 ATP binding site [chemical binding]; other site 1246995016642 Q-loop/lid; other site 1246995016643 ABC transporter signature motif; other site 1246995016644 Walker B; other site 1246995016645 D-loop; other site 1246995016646 H-loop/switch region; other site 1246995016647 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1246995016648 Histidine kinase; Region: HisKA_3; pfam07730 1246995016649 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1246995016650 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995016651 ATP binding site [chemical binding]; other site 1246995016652 Mg2+ binding site [ion binding]; other site 1246995016653 G-X-G motif; other site 1246995016654 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995016655 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995016656 active site 1246995016657 phosphorylation site [posttranslational modification] 1246995016658 intermolecular recognition site; other site 1246995016659 dimerization interface [polypeptide binding]; other site 1246995016660 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995016661 DNA binding residues [nucleotide binding] 1246995016662 dimerization interface [polypeptide binding]; other site 1246995016663 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1246995016664 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1246995016665 active site 1246995016666 motif I; other site 1246995016667 motif II; other site 1246995016668 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1246995016669 potential protein location (hypothetical protein AFR_29995 [Actinoplanes friuliensis DSM 7358]) that overlaps RNA (5S ribosomal RNA) 1246995016670 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1246995016671 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1246995016672 active site 1246995016673 HIGH motif; other site 1246995016674 dimer interface [polypeptide binding]; other site 1246995016675 KMSKS motif; other site 1246995016676 S4 domain; Region: S4_2; cl17325 1246995016677 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 1246995016678 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1246995016679 Adenylate kinase; Region: ADK; pfam00406 1246995016680 AMP-binding site [chemical binding]; other site 1246995016681 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1246995016682 PemK-like protein; Region: PemK; pfam02452 1246995016683 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1246995016684 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1246995016685 active site 1246995016686 DNA binding site [nucleotide binding] 1246995016687 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 1246995016688 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 1246995016689 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1246995016690 sugar binding site [chemical binding]; other site 1246995016691 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1246995016692 sugar binding site [chemical binding]; other site 1246995016693 SnoaL-like domain; Region: SnoaL_2; pfam12680 1246995016694 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1246995016695 putative substrate binding site [chemical binding]; other site 1246995016696 putative ATP binding site [chemical binding]; other site 1246995016697 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1246995016698 catalytic core [active] 1246995016699 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1246995016700 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1246995016701 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995016702 dimer interface [polypeptide binding]; other site 1246995016703 conserved gate region; other site 1246995016704 putative PBP binding loops; other site 1246995016705 ABC-ATPase subunit interface; other site 1246995016706 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1246995016707 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995016708 dimer interface [polypeptide binding]; other site 1246995016709 conserved gate region; other site 1246995016710 putative PBP binding loops; other site 1246995016711 ABC-ATPase subunit interface; other site 1246995016712 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 1246995016713 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 1246995016714 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 1246995016715 TrkA-C domain; Region: TrkA_C; pfam02080 1246995016716 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1246995016717 dimerization interface [polypeptide binding]; other site 1246995016718 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1246995016719 Histidine kinase; Region: HisKA_3; pfam07730 1246995016720 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995016721 ATP binding site [chemical binding]; other site 1246995016722 Mg2+ binding site [ion binding]; other site 1246995016723 G-X-G motif; other site 1246995016724 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995016725 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995016726 active site 1246995016727 phosphorylation site [posttranslational modification] 1246995016728 intermolecular recognition site; other site 1246995016729 dimerization interface [polypeptide binding]; other site 1246995016730 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995016731 DNA binding residues [nucleotide binding] 1246995016732 dimerization interface [polypeptide binding]; other site 1246995016733 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644 1246995016734 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1246995016735 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 1246995016736 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 1246995016737 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07946 1246995016738 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665 1246995016739 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1246995016740 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 1246995016741 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 1246995016742 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 1246995016743 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1246995016744 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1246995016745 active site 1246995016746 metal binding site [ion binding]; metal-binding site 1246995016747 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 1246995016748 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1246995016749 motif II; other site 1246995016750 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1246995016751 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1246995016752 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1246995016753 dimerization interface [polypeptide binding]; other site 1246995016754 substrate binding pocket [chemical binding]; other site 1246995016755 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1246995016756 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1246995016757 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1246995016758 P-loop; other site 1246995016759 Magnesium ion binding site [ion binding]; other site 1246995016760 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1246995016761 Magnesium ion binding site [ion binding]; other site 1246995016762 argininosuccinate lyase; Provisional; Region: PRK00855 1246995016763 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1246995016764 active sites [active] 1246995016765 tetramer interface [polypeptide binding]; other site 1246995016766 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1246995016767 Ligand Binding Site [chemical binding]; other site 1246995016768 arginine repressor; Provisional; Region: PRK03341 1246995016769 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1246995016770 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1246995016771 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1246995016772 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1246995016773 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1246995016774 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 1246995016775 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1246995016776 inhibitor-cofactor binding pocket; inhibition site 1246995016777 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1246995016778 catalytic residue [active] 1246995016779 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1246995016780 feedback inhibition sensing region; other site 1246995016781 homohexameric interface [polypeptide binding]; other site 1246995016782 nucleotide binding site [chemical binding]; other site 1246995016783 N-acetyl-L-glutamate binding site [chemical binding]; other site 1246995016784 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1246995016785 heterotetramer interface [polypeptide binding]; other site 1246995016786 active site pocket [active] 1246995016787 cleavage site 1246995016788 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1246995016789 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1246995016790 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 1246995016791 metal binding site [ion binding]; metal-binding site 1246995016792 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1246995016793 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1246995016794 ligand binding site [chemical binding]; other site 1246995016795 flexible hinge region; other site 1246995016796 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 1246995016797 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 1246995016798 Helix-turn-helix domain; Region: HTH_31; pfam13560 1246995016799 sequence-specific DNA binding site [nucleotide binding]; other site 1246995016800 salt bridge; other site 1246995016801 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1246995016802 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995016803 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1246995016804 Cytochrome P450; Region: p450; cl12078 1246995016805 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1246995016806 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 1246995016807 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1246995016808 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 1246995016809 Walker A/P-loop; other site 1246995016810 ATP binding site [chemical binding]; other site 1246995016811 Q-loop/lid; other site 1246995016812 ABC transporter signature motif; other site 1246995016813 Walker B; other site 1246995016814 D-loop; other site 1246995016815 H-loop/switch region; other site 1246995016816 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1246995016817 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995016818 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995016819 active site 1246995016820 phosphorylation site [posttranslational modification] 1246995016821 intermolecular recognition site; other site 1246995016822 dimerization interface [polypeptide binding]; other site 1246995016823 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995016824 DNA binding residues [nucleotide binding] 1246995016825 dimerization interface [polypeptide binding]; other site 1246995016826 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 1246995016827 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1246995016828 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1246995016829 Phosphotransferase enzyme family; Region: APH; pfam01636 1246995016830 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1246995016831 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1246995016832 extended (e) SDRs; Region: SDR_e; cd08946 1246995016833 NAD(P) binding site [chemical binding]; other site 1246995016834 active site 1246995016835 substrate binding site [chemical binding]; other site 1246995016836 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK06830 1246995016837 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1246995016838 active site 1246995016839 ADP/pyrophosphate binding site [chemical binding]; other site 1246995016840 dimerization interface [polypeptide binding]; other site 1246995016841 allosteric effector site; other site 1246995016842 fructose-1,6-bisphosphate binding site; other site 1246995016843 Predicted acetyltransferase [General function prediction only]; Region: COG3393 1246995016844 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1246995016845 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1246995016846 putative active site [active] 1246995016847 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1246995016848 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1246995016849 Walker A/P-loop; other site 1246995016850 ATP binding site [chemical binding]; other site 1246995016851 Q-loop/lid; other site 1246995016852 ABC transporter signature motif; other site 1246995016853 Walker B; other site 1246995016854 D-loop; other site 1246995016855 H-loop/switch region; other site 1246995016856 FtsX-like permease family; Region: FtsX; pfam02687 1246995016857 Putative sensor; Region: Sensor; pfam13796 1246995016858 Histidine kinase; Region: HisKA_3; pfam07730 1246995016859 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995016860 ATP binding site [chemical binding]; other site 1246995016861 Mg2+ binding site [ion binding]; other site 1246995016862 G-X-G motif; other site 1246995016863 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995016864 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1246995016865 active site 1246995016866 phosphorylation site [posttranslational modification] 1246995016867 intermolecular recognition site; other site 1246995016868 dimerization interface [polypeptide binding]; other site 1246995016869 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995016870 DNA binding residues [nucleotide binding] 1246995016871 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1246995016872 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1246995016873 DNA-binding site [nucleotide binding]; DNA binding site 1246995016874 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1246995016875 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1246995016876 Walker A/P-loop; other site 1246995016877 ATP binding site [chemical binding]; other site 1246995016878 Q-loop/lid; other site 1246995016879 ABC transporter signature motif; other site 1246995016880 Walker B; other site 1246995016881 D-loop; other site 1246995016882 H-loop/switch region; other site 1246995016883 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1246995016884 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1246995016885 M28 Zn-Peptidase Aeromonas (Vibrio) proteolytica aminopeptidase (AAP)-like; Region: M28_AAP_like; cd05642 1246995016886 putative metal binding site [ion binding]; other site 1246995016887 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1246995016888 Interdomain contacts; other site 1246995016889 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1246995016890 S-adenosylmethionine binding site [chemical binding]; other site 1246995016891 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1246995016892 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1246995016893 DinB superfamily; Region: DinB_2; pfam12867 1246995016894 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 1246995016895 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995016896 NAD(P) binding site [chemical binding]; other site 1246995016897 active site 1246995016898 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; cl17774 1246995016899 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1246995016900 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1246995016901 putative tRNA-binding site [nucleotide binding]; other site 1246995016902 B3/4 domain; Region: B3_4; pfam03483 1246995016903 tRNA synthetase B5 domain; Region: B5; smart00874 1246995016904 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1246995016905 dimer interface [polypeptide binding]; other site 1246995016906 motif 1; other site 1246995016907 motif 3; other site 1246995016908 motif 2; other site 1246995016909 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1246995016910 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1246995016911 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1246995016912 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1246995016913 dimer interface [polypeptide binding]; other site 1246995016914 motif 1; other site 1246995016915 active site 1246995016916 motif 2; other site 1246995016917 motif 3; other site 1246995016918 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1246995016919 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1246995016920 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1246995016921 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1246995016922 23S rRNA binding site [nucleotide binding]; other site 1246995016923 L21 binding site [polypeptide binding]; other site 1246995016924 L13 binding site [polypeptide binding]; other site 1246995016925 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1246995016926 translation initiation factor IF-3; Region: infC; TIGR00168 1246995016927 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1246995016928 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1246995016929 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1246995016930 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1246995016931 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 1246995016932 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 1246995016933 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 1246995016934 homodimer interface [polypeptide binding]; other site 1246995016935 putative metal binding site [ion binding]; other site 1246995016936 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1246995016937 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1246995016938 substrate binding pocket [chemical binding]; other site 1246995016939 membrane-bound complex binding site; other site 1246995016940 hinge residues; other site 1246995016941 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995016942 dimer interface [polypeptide binding]; other site 1246995016943 conserved gate region; other site 1246995016944 putative PBP binding loops; other site 1246995016945 ABC-ATPase subunit interface; other site 1246995016946 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1246995016947 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1246995016948 Walker A/P-loop; other site 1246995016949 ATP binding site [chemical binding]; other site 1246995016950 Q-loop/lid; other site 1246995016951 ABC transporter signature motif; other site 1246995016952 Walker B; other site 1246995016953 D-loop; other site 1246995016954 H-loop/switch region; other site 1246995016955 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1246995016956 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1246995016957 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1246995016958 homopentamer interface [polypeptide binding]; other site 1246995016959 active site 1246995016960 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1246995016961 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1246995016962 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1246995016963 dimerization interface [polypeptide binding]; other site 1246995016964 active site 1246995016965 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1246995016966 Lumazine binding domain; Region: Lum_binding; pfam00677 1246995016967 Lumazine binding domain; Region: Lum_binding; pfam00677 1246995016968 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1246995016969 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1246995016970 catalytic motif [active] 1246995016971 Zn binding site [ion binding]; other site 1246995016972 RibD C-terminal domain; Region: RibD_C; cl17279 1246995016973 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995016974 active site 1246995016975 phosphorylation site [posttranslational modification] 1246995016976 intermolecular recognition site; other site 1246995016977 dimerization interface [polypeptide binding]; other site 1246995016978 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1246995016979 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1246995016980 metal binding site [ion binding]; metal-binding site 1246995016981 active site 1246995016982 I-site; other site 1246995016983 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1246995016984 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1246995016985 substrate binding site [chemical binding]; other site 1246995016986 hexamer interface [polypeptide binding]; other site 1246995016987 metal binding site [ion binding]; metal-binding site 1246995016988 Septum formation; Region: Septum_form; pfam13845 1246995016989 Septum formation; Region: Septum_form; pfam13845 1246995016990 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 1246995016991 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1246995016992 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1246995016993 S-adenosylmethionine binding site [chemical binding]; other site 1246995016994 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1246995016995 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1246995016996 putative active site [active] 1246995016997 substrate binding site [chemical binding]; other site 1246995016998 putative cosubstrate binding site; other site 1246995016999 catalytic site [active] 1246995017000 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1246995017001 substrate binding site [chemical binding]; other site 1246995017002 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1246995017003 active site 1246995017004 catalytic residues [active] 1246995017005 metal binding site [ion binding]; metal-binding site 1246995017006 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1246995017007 Cytochrome P450; Region: p450; cl12078 1246995017008 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4222 1246995017009 primosome assembly protein PriA; Provisional; Region: PRK14873 1246995017010 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1246995017011 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1246995017012 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1246995017013 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1246995017014 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1246995017015 Flavoprotein; Region: Flavoprotein; pfam02441 1246995017016 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1246995017017 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 1246995017018 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1246995017019 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1246995017020 catalytic site [active] 1246995017021 G-X2-G-X-G-K; other site 1246995017022 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 1246995017023 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1246995017024 active site 1246995017025 dimer interface [polypeptide binding]; other site 1246995017026 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1246995017027 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 1246995017028 inhibitor-cofactor binding pocket; inhibition site 1246995017029 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1246995017030 catalytic residue [active] 1246995017031 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1246995017032 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1246995017033 quinone interaction residues [chemical binding]; other site 1246995017034 active site 1246995017035 catalytic residues [active] 1246995017036 FMN binding site [chemical binding]; other site 1246995017037 substrate binding site [chemical binding]; other site 1246995017038 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1246995017039 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1246995017040 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1246995017041 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1246995017042 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1246995017043 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1246995017044 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1246995017045 IMP binding site; other site 1246995017046 dimer interface [polypeptide binding]; other site 1246995017047 interdomain contacts; other site 1246995017048 partial ornithine binding site; other site 1246995017049 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1246995017050 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1246995017051 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1246995017052 catalytic site [active] 1246995017053 subunit interface [polypeptide binding]; other site 1246995017054 dihydroorotase; Validated; Region: pyrC; PRK09357 1246995017055 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1246995017056 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1246995017057 active site 1246995017058 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1246995017059 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1246995017060 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1246995017061 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1246995017062 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1246995017063 active site 1246995017064 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1246995017065 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1246995017066 non-specific DNA binding site [nucleotide binding]; other site 1246995017067 salt bridge; other site 1246995017068 sequence-specific DNA binding site [nucleotide binding]; other site 1246995017069 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 1246995017070 putative RNA binding site [nucleotide binding]; other site 1246995017071 elongation factor P; Validated; Region: PRK00529 1246995017072 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1246995017073 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1246995017074 RNA binding site [nucleotide binding]; other site 1246995017075 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1246995017076 RNA binding site [nucleotide binding]; other site 1246995017077 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1246995017078 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1246995017079 trimer interface [polypeptide binding]; other site 1246995017080 active site 1246995017081 dimer interface [polypeptide binding]; other site 1246995017082 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1246995017083 dimer interface [polypeptide binding]; other site 1246995017084 active site 1246995017085 metal binding site [ion binding]; metal-binding site 1246995017086 Clp amino terminal domain; Region: Clp_N; pfam02861 1246995017087 Predicted transcriptional regulator [Transcription]; Region: COG2378 1246995017088 HTH domain; Region: HTH_11; pfam08279 1246995017089 WYL domain; Region: WYL; pfam13280 1246995017090 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1246995017091 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1246995017092 Shikimate kinase; Region: SKI; pfam01202 1246995017093 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1246995017094 ADP binding site [chemical binding]; other site 1246995017095 magnesium binding site [ion binding]; other site 1246995017096 putative shikimate binding site; other site 1246995017097 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1246995017098 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1246995017099 Tetramer interface [polypeptide binding]; other site 1246995017100 active site 1246995017101 FMN-binding site [chemical binding]; other site 1246995017102 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1246995017103 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1246995017104 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1246995017105 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1246995017106 NAD(P) binding site [chemical binding]; other site 1246995017107 shikimate binding site; other site 1246995017108 YceG-like family; Region: YceG; pfam02618 1246995017109 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 1246995017110 dimerization interface [polypeptide binding]; other site 1246995017111 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1246995017112 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1246995017113 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1246995017114 motif 1; other site 1246995017115 active site 1246995017116 motif 2; other site 1246995017117 motif 3; other site 1246995017118 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1246995017119 recombination factor protein RarA; Reviewed; Region: PRK13342 1246995017120 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1246995017121 Walker A motif; other site 1246995017122 ATP binding site [chemical binding]; other site 1246995017123 Walker B motif; other site 1246995017124 arginine finger; other site 1246995017125 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1246995017126 Predicted transcriptional regulator [Transcription]; Region: COG2345 1246995017127 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1246995017128 putative DNA binding site [nucleotide binding]; other site 1246995017129 putative Zn2+ binding site [ion binding]; other site 1246995017130 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1246995017131 Coenzyme A binding pocket [chemical binding]; other site 1246995017132 Protein of unknown function (DUF1345); Region: DUF1345; cl01753 1246995017133 Protein of unknown function (DUF4243); Region: DUF4243; pfam14027 1246995017134 HAMP domain; Region: HAMP; pfam00672 1246995017135 dimerization interface [polypeptide binding]; other site 1246995017136 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1246995017137 dimer interface [polypeptide binding]; other site 1246995017138 phosphorylation site [posttranslational modification] 1246995017139 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995017140 Mg2+ binding site [ion binding]; other site 1246995017141 G-X-G motif; other site 1246995017142 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1246995017143 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995017144 active site 1246995017145 phosphorylation site [posttranslational modification] 1246995017146 intermolecular recognition site; other site 1246995017147 dimerization interface [polypeptide binding]; other site 1246995017148 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1246995017149 DNA binding site [nucleotide binding] 1246995017150 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1246995017151 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995017152 Walker A/P-loop; other site 1246995017153 ATP binding site [chemical binding]; other site 1246995017154 Q-loop/lid; other site 1246995017155 ABC transporter signature motif; other site 1246995017156 Walker B; other site 1246995017157 D-loop; other site 1246995017158 H-loop/switch region; other site 1246995017159 Protein of unknown function (DUF1349); Region: DUF1349; cl01397 1246995017160 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 1246995017161 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995017162 NAD(P) binding site [chemical binding]; other site 1246995017163 active site 1246995017164 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1246995017165 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1246995017166 dimer interface [polypeptide binding]; other site 1246995017167 anticodon binding site; other site 1246995017168 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1246995017169 homodimer interface [polypeptide binding]; other site 1246995017170 motif 1; other site 1246995017171 active site 1246995017172 motif 2; other site 1246995017173 GAD domain; Region: GAD; pfam02938 1246995017174 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1246995017175 motif 3; other site 1246995017176 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1246995017177 putative DNA binding site [nucleotide binding]; other site 1246995017178 putative Zn2+ binding site [ion binding]; other site 1246995017179 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1246995017180 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1246995017181 AsnC family; Region: AsnC_trans_reg; pfam01037 1246995017182 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1246995017183 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1246995017184 putative substrate translocation pore; other site 1246995017185 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895 1246995017186 Hemerythrin-like domain; Region: Hr-like; cd12108 1246995017187 Fe binding site [ion binding]; other site 1246995017188 Tetratrico peptide repeat; Region: TPR_5; pfam12688 1246995017189 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 1246995017190 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 1246995017191 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 1246995017192 active site 1246995017193 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1246995017194 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995017195 dimer interface [polypeptide binding]; other site 1246995017196 conserved gate region; other site 1246995017197 putative PBP binding loops; other site 1246995017198 ABC-ATPase subunit interface; other site 1246995017199 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995017200 putative PBP binding loops; other site 1246995017201 dimer interface [polypeptide binding]; other site 1246995017202 ABC-ATPase subunit interface; other site 1246995017203 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1246995017204 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1246995017205 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1246995017206 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 1246995017207 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1246995017208 catalytic residue [active] 1246995017209 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 1246995017210 dihydroorotase; Provisional; Region: PRK09237 1246995017211 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1246995017212 active site 1246995017213 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1246995017214 homotrimer interaction site [polypeptide binding]; other site 1246995017215 putative active site [active] 1246995017216 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1246995017217 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1246995017218 alpha-gamma subunit interface [polypeptide binding]; other site 1246995017219 beta-gamma subunit interface [polypeptide binding]; other site 1246995017220 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1246995017221 gamma-beta subunit interface [polypeptide binding]; other site 1246995017222 alpha-beta subunit interface [polypeptide binding]; other site 1246995017223 urease subunit alpha; Reviewed; Region: ureC; PRK13206 1246995017224 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1246995017225 subunit interactions [polypeptide binding]; other site 1246995017226 active site 1246995017227 flap region; other site 1246995017228 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 1246995017229 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1246995017230 UreD urease accessory protein; Region: UreD; cl00530 1246995017231 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 1246995017232 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1246995017233 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1246995017234 DNA binding residues [nucleotide binding] 1246995017235 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1246995017236 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1246995017237 active site 1246995017238 ATP binding site [chemical binding]; other site 1246995017239 substrate binding site [chemical binding]; other site 1246995017240 activation loop (A-loop); other site 1246995017241 Cellulose binding domain; Region: CBM_2; cl17741 1246995017242 cyanophycin synthetase; Provisional; Region: PRK14016 1246995017243 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1246995017244 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1246995017245 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1246995017246 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 1246995017247 proposed catalytic triad [active] 1246995017248 active site nucleophile [active] 1246995017249 Transmembrane secretion effector; Region: MFS_3; pfam05977 1246995017250 Predicted transcriptional regulators [Transcription]; Region: COG1733 1246995017251 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1246995017252 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1246995017253 CoenzymeA binding site [chemical binding]; other site 1246995017254 subunit interaction site [polypeptide binding]; other site 1246995017255 PHB binding site; other site 1246995017256 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 1246995017257 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1246995017258 Walker A/P-loop; other site 1246995017259 ATP binding site [chemical binding]; other site 1246995017260 Q-loop/lid; other site 1246995017261 ABC transporter signature motif; other site 1246995017262 Walker B; other site 1246995017263 D-loop; other site 1246995017264 H-loop/switch region; other site 1246995017265 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 1246995017266 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1246995017267 Walker A/P-loop; other site 1246995017268 ATP binding site [chemical binding]; other site 1246995017269 Q-loop/lid; other site 1246995017270 ABC transporter signature motif; other site 1246995017271 Walker B; other site 1246995017272 D-loop; other site 1246995017273 H-loop/switch region; other site 1246995017274 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1246995017275 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1246995017276 TM-ABC transporter signature motif; other site 1246995017277 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1246995017278 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1246995017279 TM-ABC transporter signature motif; other site 1246995017280 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1246995017281 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 1246995017282 putative ligand binding site [chemical binding]; other site 1246995017283 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1246995017284 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1246995017285 classical (c) SDRs; Region: SDR_c; cd05233 1246995017286 NAD(P) binding site [chemical binding]; other site 1246995017287 active site 1246995017288 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995017289 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995017290 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1246995017291 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1246995017292 dimer interface [polypeptide binding]; other site 1246995017293 motif 1; other site 1246995017294 active site 1246995017295 motif 2; other site 1246995017296 motif 3; other site 1246995017297 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1246995017298 anticodon binding site; other site 1246995017299 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1246995017300 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 1246995017301 active site 1246995017302 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1246995017303 active site 1246995017304 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1246995017305 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1246995017306 Zn2+ binding site [ion binding]; other site 1246995017307 Mg2+ binding site [ion binding]; other site 1246995017308 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1246995017309 synthetase active site [active] 1246995017310 NTP binding site [chemical binding]; other site 1246995017311 metal binding site [ion binding]; metal-binding site 1246995017312 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1246995017313 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1246995017314 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1246995017315 active site 1246995017316 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1246995017317 Protein export membrane protein; Region: SecD_SecF; cl14618 1246995017318 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1246995017319 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1246995017320 Preprotein translocase subunit; Region: YajC; pfam02699 1246995017321 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1246995017322 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1246995017323 Walker A motif; other site 1246995017324 ATP binding site [chemical binding]; other site 1246995017325 Walker B motif; other site 1246995017326 arginine finger; other site 1246995017327 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1246995017328 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1246995017329 RuvA N terminal domain; Region: RuvA_N; pfam01330 1246995017330 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 1246995017331 active site 1246995017332 putative DNA-binding cleft [nucleotide binding]; other site 1246995017333 dimer interface [polypeptide binding]; other site 1246995017334 large tegument protein UL36; Provisional; Region: PHA03247 1246995017335 hypothetical protein; Validated; Region: PRK00110 1246995017336 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1246995017337 imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; Region: IMP_synth_hisH; TIGR01855 1246995017338 predicted active site [active] 1246995017339 catalytic triad [active] 1246995017340 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1246995017341 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1246995017342 active site 1246995017343 multimer interface [polypeptide binding]; other site 1246995017344 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 1246995017345 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1246995017346 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1246995017347 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1246995017348 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 1246995017349 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1246995017350 putative acyl-acceptor binding pocket; other site 1246995017351 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1246995017352 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 1246995017353 elongation factor G; Reviewed; Region: PRK12740 1246995017354 G1 box; other site 1246995017355 putative GEF interaction site [polypeptide binding]; other site 1246995017356 GTP/Mg2+ binding site [chemical binding]; other site 1246995017357 Switch I region; other site 1246995017358 G2 box; other site 1246995017359 G3 box; other site 1246995017360 Switch II region; other site 1246995017361 G4 box; other site 1246995017362 G5 box; other site 1246995017363 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1246995017364 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1246995017365 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1246995017366 hypothetical protein; Provisional; Region: PRK07236 1246995017367 hypothetical protein; Provisional; Region: PRK07588 1246995017368 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995017369 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995017370 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1246995017371 metal binding site [ion binding]; metal-binding site 1246995017372 active site 1246995017373 I-site; other site 1246995017374 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1246995017375 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1246995017376 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1246995017377 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 1246995017378 nucleotide binding site/active site [active] 1246995017379 HIT family signature motif; other site 1246995017380 catalytic residue [active] 1246995017381 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 1246995017382 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995017383 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1246995017384 DNA binding residues [nucleotide binding] 1246995017385 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 1246995017386 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1246995017387 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1246995017388 active site 1246995017389 dimer interface [polypeptide binding]; other site 1246995017390 motif 1; other site 1246995017391 motif 2; other site 1246995017392 motif 3; other site 1246995017393 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1246995017394 anticodon binding site; other site 1246995017395 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 1246995017396 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1246995017397 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995017398 active site 1246995017399 phosphorylation site [posttranslational modification] 1246995017400 intermolecular recognition site; other site 1246995017401 dimerization interface [polypeptide binding]; other site 1246995017402 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1246995017403 DNA binding site [nucleotide binding] 1246995017404 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1246995017405 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1246995017406 dimerization interface [polypeptide binding]; other site 1246995017407 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1246995017408 dimer interface [polypeptide binding]; other site 1246995017409 phosphorylation site [posttranslational modification] 1246995017410 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995017411 ATP binding site [chemical binding]; other site 1246995017412 Mg2+ binding site [ion binding]; other site 1246995017413 G-X-G motif; other site 1246995017414 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1246995017415 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1246995017416 putative sugar binding sites [chemical binding]; other site 1246995017417 Q-X-W motif; other site 1246995017418 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1246995017419 adenosine deaminase; Provisional; Region: PRK09358 1246995017420 active site 1246995017421 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 1246995017422 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1246995017423 S-adenosylmethionine binding site [chemical binding]; other site 1246995017424 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1246995017425 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1246995017426 active site 1246995017427 catalytic tetrad [active] 1246995017428 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1246995017429 DNA-binding site [nucleotide binding]; DNA binding site 1246995017430 RNA-binding motif; other site 1246995017431 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 1246995017432 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 1246995017433 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1246995017434 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1246995017435 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 1246995017436 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 1246995017437 Predicted acetyltransferase [General function prediction only]; Region: COG2388 1246995017438 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1246995017439 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1246995017440 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1246995017441 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 1246995017442 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1246995017443 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1246995017444 ATP binding site [chemical binding]; other site 1246995017445 putative Mg++ binding site [ion binding]; other site 1246995017446 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1246995017447 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1246995017448 nucleotide binding region [chemical binding]; other site 1246995017449 ATP-binding site [chemical binding]; other site 1246995017450 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1246995017451 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1246995017452 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1246995017453 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 1246995017454 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1246995017455 RibD C-terminal domain; Region: RibD_C; cl17279 1246995017456 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1246995017457 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995017458 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995017459 active site 1246995017460 phosphorylation site [posttranslational modification] 1246995017461 intermolecular recognition site; other site 1246995017462 dimerization interface [polypeptide binding]; other site 1246995017463 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995017464 DNA binding residues [nucleotide binding] 1246995017465 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1246995017466 Histidine kinase; Region: HisKA_3; pfam07730 1246995017467 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995017468 ATP binding site [chemical binding]; other site 1246995017469 Mg2+ binding site [ion binding]; other site 1246995017470 G-X-G motif; other site 1246995017471 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1246995017472 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1246995017473 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1246995017474 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1246995017475 Walker A/P-loop; other site 1246995017476 ATP binding site [chemical binding]; other site 1246995017477 Q-loop/lid; other site 1246995017478 ABC transporter signature motif; other site 1246995017479 Walker B; other site 1246995017480 D-loop; other site 1246995017481 H-loop/switch region; other site 1246995017482 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 1246995017483 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 1246995017484 putative ADP-binding pocket [chemical binding]; other site 1246995017485 short chain dehydrogenase; Provisional; Region: PRK07109 1246995017486 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 1246995017487 putative NAD(P) binding site [chemical binding]; other site 1246995017488 active site 1246995017489 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1246995017490 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1246995017491 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1246995017492 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1246995017493 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 1246995017494 putative hydrophobic ligand binding site [chemical binding]; other site 1246995017495 Conserved TM helix; Region: TM_helix; pfam05552 1246995017496 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1246995017497 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1246995017498 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1246995017499 oxidoreductase; Provisional; Region: PRK12743 1246995017500 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995017501 NAD(P) binding site [chemical binding]; other site 1246995017502 active site 1246995017503 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1246995017504 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1246995017505 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1246995017506 Protein of unknown function (DUF3072); Region: DUF3072; pfam11272 1246995017507 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2739; cl17893 1246995017508 Clp amino terminal domain; Region: Clp_N; pfam02861 1246995017509 Clp amino terminal domain; Region: Clp_N; pfam02861 1246995017510 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1246995017511 active site 1246995017512 NTP binding site [chemical binding]; other site 1246995017513 metal binding triad [ion binding]; metal-binding site 1246995017514 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1246995017515 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 1246995017516 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1246995017517 active site 1246995017518 motif I; other site 1246995017519 motif II; other site 1246995017520 MarR family; Region: MarR_2; pfam12802 1246995017521 Pirin-related protein [General function prediction only]; Region: COG1741 1246995017522 Pirin; Region: Pirin; pfam02678 1246995017523 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1246995017524 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995017525 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1246995017526 NAD(P) binding site [chemical binding]; other site 1246995017527 active site 1246995017528 Predicted transcriptional regulators [Transcription]; Region: COG1733 1246995017529 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1246995017530 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 1246995017531 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1246995017532 putative active site [active] 1246995017533 catalytic site [active] 1246995017534 Catalytic domain, repeat 2, of vertebrate phospholipases, PLD1 and PLD2, and similar proteins; Region: PLDc_vPLD1_2_like_2; cd09105 1246995017535 putative active site [active] 1246995017536 catalytic site [active] 1246995017537 Putative sensor; Region: Sensor; pfam13796 1246995017538 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1246995017539 Histidine kinase; Region: HisKA_3; pfam07730 1246995017540 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1246995017541 ATP binding site [chemical binding]; other site 1246995017542 Mg2+ binding site [ion binding]; other site 1246995017543 G-X-G motif; other site 1246995017544 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995017545 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995017546 active site 1246995017547 phosphorylation site [posttranslational modification] 1246995017548 intermolecular recognition site; other site 1246995017549 dimerization interface [polypeptide binding]; other site 1246995017550 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995017551 dimerization interface [polypeptide binding]; other site 1246995017552 DNA binding residues [nucleotide binding] 1246995017553 methyltransferase, ATP-grasp peptide maturase system; Region: methyltr_grsp; TIGR04188 1246995017554 Phosphotransferase enzyme family; Region: APH; pfam01636 1246995017555 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1246995017556 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1246995017557 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1246995017558 allantoicase; Provisional; Region: PRK13257 1246995017559 Allantoicase repeat; Region: Allantoicase; pfam03561 1246995017560 Allantoicase repeat; Region: Allantoicase; pfam03561 1246995017561 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1246995017562 allantoinase; Region: allantoinase; TIGR03178 1246995017563 active site 1246995017564 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1246995017565 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 1246995017566 malate synthase A; Region: malate_syn_A; TIGR01344 1246995017567 active site 1246995017568 Carbohydrate Binding Module 6 (CBM6); appended to glycoside hydrolase (GH) domains, including GH5 (cellulase); Region: CBM6_cellulase-like; cd04080 1246995017569 Ca binding site [ion binding]; other site 1246995017570 ligand binding site I [chemical binding]; other site 1246995017571 homodimer interface [polypeptide binding]; other site 1246995017572 ligand binding site II [chemical binding]; other site 1246995017573 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 1246995017574 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 1246995017575 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 1246995017576 active site 1246995017577 putative substrate binding pocket [chemical binding]; other site 1246995017578 urate oxidase; Region: urate_oxi; TIGR03383 1246995017579 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1246995017580 active site 1246995017581 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 1246995017582 active site 1246995017583 homotetramer interface [polypeptide binding]; other site 1246995017584 putative OHCU decarboxylase; Provisional; Region: PRK13798 1246995017585 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 1246995017586 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1246995017587 ATP binding site [chemical binding]; other site 1246995017588 putative Mg++ binding site [ion binding]; other site 1246995017589 nucleotide binding region [chemical binding]; other site 1246995017590 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1246995017591 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 1246995017592 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 1246995017593 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1246995017594 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1246995017595 metal binding site [ion binding]; metal-binding site 1246995017596 active site 1246995017597 I-site; other site 1246995017598 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1246995017599 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1246995017600 active site 1246995017601 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1246995017602 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1246995017603 substrate binding pocket [chemical binding]; other site 1246995017604 membrane-bound complex binding site; other site 1246995017605 hinge residues; other site 1246995017606 Haemolytic domain; Region: Haemolytic; pfam01809 1246995017607 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 1246995017608 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 1246995017609 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 1246995017610 catalytic site [active] 1246995017611 active site 1246995017612 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1246995017613 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 1246995017614 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 1246995017615 active site 1246995017616 catalytic site [active] 1246995017617 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1246995017618 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1246995017619 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1246995017620 active site 1246995017621 catalytic site [active] 1246995017622 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 1246995017623 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 1246995017624 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1246995017625 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 1246995017626 active site 1246995017627 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1246995017628 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1246995017629 active site 1246995017630 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1246995017631 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1246995017632 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1246995017633 acyl-activating enzyme (AAE) consensus motif; other site 1246995017634 AMP binding site [chemical binding]; other site 1246995017635 active site 1246995017636 CoA binding site [chemical binding]; other site 1246995017637 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1246995017638 active site 1246995017639 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1246995017640 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995017641 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1246995017642 NAD(P) binding site [chemical binding]; other site 1246995017643 active site 1246995017644 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 1246995017645 EcsC protein family; Region: EcsC; pfam12787 1246995017646 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1246995017647 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1246995017648 metal binding site [ion binding]; metal-binding site 1246995017649 active site 1246995017650 I-site; other site 1246995017651 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1246995017652 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1246995017653 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1246995017654 dimer interface [polypeptide binding]; other site 1246995017655 putative CheW interface [polypeptide binding]; other site 1246995017656 PAC2 family; Region: PAC2; pfam09754 1246995017657 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 1246995017658 active site 1246995017659 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102 1246995017660 IPT/TIG domain; Region: TIG; pfam01833 1246995017661 GAF domain; Region: GAF_2; pfam13185 1246995017662 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1246995017663 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1246995017664 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1246995017665 dimer interface [polypeptide binding]; other site 1246995017666 putative CheW interface [polypeptide binding]; other site 1246995017667 S-formylglutathione hydrolase; Region: PLN02442 1246995017668 Putative esterase; Region: Esterase; pfam00756 1246995017669 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 1246995017670 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 1246995017671 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1246995017672 S-adenosylmethionine binding site [chemical binding]; other site 1246995017673 GAF domain; Region: GAF; pfam01590 1246995017674 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1246995017675 PAS fold; Region: PAS_4; pfam08448 1246995017676 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1246995017677 putative active site [active] 1246995017678 heme pocket [chemical binding]; other site 1246995017679 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1246995017680 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1246995017681 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1246995017682 dimer interface [polypeptide binding]; other site 1246995017683 phosphorylation site [posttranslational modification] 1246995017684 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995017685 ATP binding site [chemical binding]; other site 1246995017686 Mg2+ binding site [ion binding]; other site 1246995017687 G-X-G motif; other site 1246995017688 56kDa selenium binding protein (SBP56); Region: SBP56; pfam05694 1246995017689 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1246995017690 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1246995017691 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1246995017692 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1246995017693 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1246995017694 Walker A/P-loop; other site 1246995017695 ATP binding site [chemical binding]; other site 1246995017696 Q-loop/lid; other site 1246995017697 ABC transporter signature motif; other site 1246995017698 Walker B; other site 1246995017699 D-loop; other site 1246995017700 H-loop/switch region; other site 1246995017701 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1246995017702 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1246995017703 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995017704 Walker A/P-loop; other site 1246995017705 ATP binding site [chemical binding]; other site 1246995017706 Q-loop/lid; other site 1246995017707 ABC transporter signature motif; other site 1246995017708 Walker B; other site 1246995017709 D-loop; other site 1246995017710 H-loop/switch region; other site 1246995017711 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1246995017712 TAP-like protein; Region: Abhydrolase_4; pfam08386 1246995017713 Peptidase M14 Carboxypeptidase T subfamily; Region: M14_CPT; cd03859 1246995017714 putative active site [active] 1246995017715 Zn binding site [ion binding]; other site 1246995017716 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 1246995017717 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1246995017718 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1246995017719 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u2; cd11478 1246995017720 Na binding site [ion binding]; other site 1246995017721 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 1246995017722 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 1246995017723 Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566 1246995017724 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 1246995017725 This novel putative carbohydrate binding module (NPCBM) domain is found at the N-terminus of glycosyl hydrolase family 98 proteins; Region: NPCBM; smart00776 1246995017726 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1246995017727 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995017728 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1246995017729 hypothetical protein; Provisional; Region: PRK07588 1246995017730 hypothetical protein; Provisional; Region: PRK07236 1246995017731 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 1246995017732 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1246995017733 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1246995017734 motif II; other site 1246995017735 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 1246995017736 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1246995017737 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1246995017738 Ligand binding site; other site 1246995017739 Putative Catalytic site; other site 1246995017740 DXD motif; other site 1246995017741 glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554 1246995017742 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 1246995017743 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1246995017744 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1246995017745 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995017746 Glycosyl hydrolase catalytic core; Region: Glyco_hydro_cc; pfam11790 1246995017747 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1246995017748 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995017749 ATP binding site [chemical binding]; other site 1246995017750 Mg2+ binding site [ion binding]; other site 1246995017751 G-X-G motif; other site 1246995017752 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1246995017753 MarR family; Region: MarR_2; pfam12802 1246995017754 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 1246995017755 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1246995017756 Lsr2; Region: Lsr2; pfam11774 1246995017757 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1246995017758 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1246995017759 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 1246995017760 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 1246995017761 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995017762 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1246995017763 DNA binding residues [nucleotide binding] 1246995017764 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1246995017765 Part of AAA domain; Region: AAA_19; pfam13245 1246995017766 Family description; Region: UvrD_C_2; pfam13538 1246995017767 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 1246995017768 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1246995017769 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1246995017770 DNA binding residues [nucleotide binding] 1246995017771 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1246995017772 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1246995017773 ATP binding site [chemical binding]; other site 1246995017774 Mg++ binding site [ion binding]; other site 1246995017775 motif III; other site 1246995017776 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1246995017777 nucleotide binding region [chemical binding]; other site 1246995017778 ATP-binding site [chemical binding]; other site 1246995017779 YceI-like domain; Region: YceI; pfam04264 1246995017780 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995017781 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995017782 DNA binding residues [nucleotide binding] 1246995017783 dimerization interface [polypeptide binding]; other site 1246995017784 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 1246995017785 Uncharacterized conserved protein [Function unknown]; Region: COG4850 1246995017786 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 1246995017787 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1246995017788 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1246995017789 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1246995017790 DNA binding site [nucleotide binding] 1246995017791 domain linker motif; other site 1246995017792 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1246995017793 dimerization interface [polypeptide binding]; other site 1246995017794 ligand binding site [chemical binding]; other site 1246995017795 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1246995017796 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 1246995017797 substrate binding site [chemical binding]; other site 1246995017798 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1246995017799 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1246995017800 Walker A/P-loop; other site 1246995017801 ATP binding site [chemical binding]; other site 1246995017802 Q-loop/lid; other site 1246995017803 ABC transporter signature motif; other site 1246995017804 Walker B; other site 1246995017805 D-loop; other site 1246995017806 H-loop/switch region; other site 1246995017807 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1246995017808 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1246995017809 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995017810 dimer interface [polypeptide binding]; other site 1246995017811 conserved gate region; other site 1246995017812 putative PBP binding loops; other site 1246995017813 ABC-ATPase subunit interface; other site 1246995017814 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1246995017815 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1246995017816 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995017817 putative PBP binding loops; other site 1246995017818 dimer interface [polypeptide binding]; other site 1246995017819 ABC-ATPase subunit interface; other site 1246995017820 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1246995017821 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1246995017822 Walker A/P-loop; other site 1246995017823 ATP binding site [chemical binding]; other site 1246995017824 Q-loop/lid; other site 1246995017825 ABC transporter signature motif; other site 1246995017826 Walker B; other site 1246995017827 D-loop; other site 1246995017828 H-loop/switch region; other site 1246995017829 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1246995017830 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1246995017831 beta-galactosidase; Region: BGL; TIGR03356 1246995017832 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1246995017833 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1246995017834 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1246995017835 S-adenosylmethionine binding site [chemical binding]; other site 1246995017836 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1246995017837 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1246995017838 metal binding site [ion binding]; metal-binding site 1246995017839 active site 1246995017840 I-site; other site 1246995017841 MarR family; Region: MarR_2; pfam12802 1246995017842 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1246995017843 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1246995017844 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1246995017845 active site 1246995017846 catalytic tetrad [active] 1246995017847 Cupin domain; Region: Cupin_2; pfam07883 1246995017848 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1246995017849 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1246995017850 putative DNA binding site [nucleotide binding]; other site 1246995017851 putative Zn2+ binding site [ion binding]; other site 1246995017852 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1246995017853 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1246995017854 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1246995017855 sequence-specific DNA binding site [nucleotide binding]; other site 1246995017856 salt bridge; other site 1246995017857 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1246995017858 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1246995017859 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1246995017860 CAP-like domain; other site 1246995017861 active site 1246995017862 primary dimer interface [polypeptide binding]; other site 1246995017863 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1246995017864 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1246995017865 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 1246995017866 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995017867 ATP binding site [chemical binding]; other site 1246995017868 Mg2+ binding site [ion binding]; other site 1246995017869 G-X-G motif; other site 1246995017870 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1246995017871 anchoring element; other site 1246995017872 dimer interface [polypeptide binding]; other site 1246995017873 ATP binding site [chemical binding]; other site 1246995017874 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1246995017875 active site 1246995017876 metal binding site [ion binding]; metal-binding site 1246995017877 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1246995017878 potential frameshift: common BLAST hit: gi|386848360|ref|YP_006266373.1| serine/threonine kinase protein 1246995017879 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1246995017880 cyclase homology domain; Region: CHD; cd07302 1246995017881 nucleotidyl binding site; other site 1246995017882 metal binding site [ion binding]; metal-binding site 1246995017883 dimer interface [polypeptide binding]; other site 1246995017884 Predicted ATPase [General function prediction only]; Region: COG3899 1246995017885 AAA ATPase domain; Region: AAA_16; pfam13191 1246995017886 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995017887 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995017888 DNA binding residues [nucleotide binding] 1246995017889 dimerization interface [polypeptide binding]; other site 1246995017890 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1246995017891 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1246995017892 dimerization interface [polypeptide binding]; other site 1246995017893 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1246995017894 dimer interface [polypeptide binding]; other site 1246995017895 phosphorylation site [posttranslational modification] 1246995017896 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1246995017897 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995017898 active site 1246995017899 phosphorylation site [posttranslational modification] 1246995017900 intermolecular recognition site; other site 1246995017901 dimerization interface [polypeptide binding]; other site 1246995017902 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1246995017903 DNA binding site [nucleotide binding] 1246995017904 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 1246995017905 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995017906 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1246995017907 DNA binding residues [nucleotide binding] 1246995017908 YCII-related domain; Region: YCII; cl00999 1246995017909 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1246995017910 sugar binding site [chemical binding]; other site 1246995017911 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1246995017912 sugar binding site [chemical binding]; other site 1246995017913 Streptomyces laminarinase-like, member of glycosyl hydrolase family 16; Region: GH16_Strep_laminarinase_like; cd02182 1246995017914 active site 1246995017915 catalytic residues [active] 1246995017916 Glucanosyltransferase; Region: Glyco_hydro_72; pfam03198 1246995017917 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 1246995017918 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1246995017919 Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231 1246995017920 sugar binding site [chemical binding]; other site 1246995017921 PQQ-like domain; Region: PQQ_2; pfam13360 1246995017922 PQQ-like domain; Region: PQQ_2; pfam13360 1246995017923 PQQ-like domain; Region: PQQ_2; pfam13360 1246995017924 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1246995017925 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1246995017926 putative catalytic site [active] 1246995017927 putative metal binding site [ion binding]; other site 1246995017928 putative phosphate binding site [ion binding]; other site 1246995017929 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1246995017930 sugar binding site [chemical binding]; other site 1246995017931 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1246995017932 sugar binding site [chemical binding]; other site 1246995017933 Domain of unknown function (DUF305); Region: DUF305; cl17794 1246995017934 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1246995017935 sugar binding site [chemical binding]; other site 1246995017936 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 1246995017937 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1246995017938 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1246995017939 DNA binding site [nucleotide binding] 1246995017940 domain linker motif; other site 1246995017941 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1246995017942 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1246995017943 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1246995017944 active site 1246995017945 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 1246995017946 hypothetical protein; Provisional; Region: PRK06834 1246995017947 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1246995017948 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1246995017949 active site 1246995017950 catalytic triad [active] 1246995017951 oxyanion hole [active] 1246995017952 DDE superfamily endonuclease; Region: DDE_5; pfam13546 1246995017953 AAA ATPase domain; Region: AAA_16; pfam13191 1246995017954 Predicted ATPase [General function prediction only]; Region: COG3903 1246995017955 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1246995017956 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 1246995017957 dimerization interface [polypeptide binding]; other site 1246995017958 NAD binding site [chemical binding]; other site 1246995017959 ligand binding site [chemical binding]; other site 1246995017960 catalytic site [active] 1246995017961 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995017962 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995017963 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 1246995017964 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 1246995017965 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 1246995017966 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 1246995017967 putative dimer interface [polypeptide binding]; other site 1246995017968 N-terminal domain interface [polypeptide binding]; other site 1246995017969 putative substrate binding pocket (H-site) [chemical binding]; other site 1246995017970 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 1246995017971 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1246995017972 MarR family; Region: MarR; pfam01047 1246995017973 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1246995017974 EamA-like transporter family; Region: EamA; pfam00892 1246995017975 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995017976 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1246995017977 NAD(P) binding site [chemical binding]; other site 1246995017978 active site 1246995017979 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995017980 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995017981 short chain dehydrogenase; Provisional; Region: PRK05854 1246995017982 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995017983 NAD(P) binding site [chemical binding]; other site 1246995017984 active site 1246995017985 SWIM zinc finger; Region: SWIM; pfam04434 1246995017986 MoxR-like ATPases [General function prediction only]; Region: COG0714 1246995017987 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 1246995017988 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 1246995017989 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1246995017990 metal ion-dependent adhesion site (MIDAS); other site 1246995017991 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1246995017992 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 1246995017993 active site 1246995017994 catalytic triad [active] 1246995017995 dimer interface [polypeptide binding]; other site 1246995017996 SnoaL-like domain; Region: SnoaL_2; pfam12680 1246995017997 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 1246995017998 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1246995017999 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1246995018000 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1246995018001 Nuclease subunit of the excinuclease complex [DNA replication, recombination, and repair]; Region: UvrC; COG0322 1246995018002 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1246995018003 GIY-YIG motif/motif A; other site 1246995018004 active site 1246995018005 catalytic site [active] 1246995018006 putative DNA binding site [nucleotide binding]; other site 1246995018007 metal binding site [ion binding]; metal-binding site 1246995018008 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1246995018009 Coenzyme A binding pocket [chemical binding]; other site 1246995018010 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1246995018011 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1246995018012 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 1246995018013 ADP-ribose binding site [chemical binding]; other site 1246995018014 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1246995018015 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1246995018016 Walker A/P-loop; other site 1246995018017 ATP binding site [chemical binding]; other site 1246995018018 Q-loop/lid; other site 1246995018019 ABC transporter signature motif; other site 1246995018020 Walker B; other site 1246995018021 D-loop; other site 1246995018022 H-loop/switch region; other site 1246995018023 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1246995018024 ABC-ATPase subunit interface; other site 1246995018025 dimer interface [polypeptide binding]; other site 1246995018026 putative PBP binding regions; other site 1246995018027 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1246995018028 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1246995018029 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1246995018030 ABC-ATPase subunit interface; other site 1246995018031 dimer interface [polypeptide binding]; other site 1246995018032 putative PBP binding regions; other site 1246995018033 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1246995018034 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1246995018035 intersubunit interface [polypeptide binding]; other site 1246995018036 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1246995018037 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1246995018038 Walker A motif; other site 1246995018039 ATP binding site [chemical binding]; other site 1246995018040 Walker B motif; other site 1246995018041 arginine finger; other site 1246995018042 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995018043 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1246995018044 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995018045 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995018046 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995018047 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1246995018048 NAD(P) binding site [chemical binding]; other site 1246995018049 active site 1246995018050 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1246995018051 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1246995018052 putative Zn2+ binding site [ion binding]; other site 1246995018053 putative DNA binding site [nucleotide binding]; other site 1246995018054 H+ Antiporter protein; Region: 2A0121; TIGR00900 1246995018055 Adenylosuccinate synthetase; Region: Adenylsucc_synt; pfam00709 1246995018056 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1246995018057 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1246995018058 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 1246995018059 active site 1246995018060 ATP binding site [chemical binding]; other site 1246995018061 substrate binding site [chemical binding]; other site 1246995018062 activation loop (A-loop); other site 1246995018063 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 1246995018064 nudix motif; other site 1246995018065 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 1246995018066 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 1246995018067 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 1246995018068 Patatin-like phospholipase; Region: Patatin; pfam01734 1246995018069 nucleophile elbow; other site 1246995018070 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 1246995018071 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1246995018072 DNA binding residues [nucleotide binding] 1246995018073 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1246995018074 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 1246995018075 Moco binding site; other site 1246995018076 metal coordination site [ion binding]; other site 1246995018077 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1246995018078 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_3; cd06217 1246995018079 FAD binding pocket [chemical binding]; other site 1246995018080 FAD binding motif [chemical binding]; other site 1246995018081 phosphate binding motif [ion binding]; other site 1246995018082 beta-alpha-beta structure motif; other site 1246995018083 NAD binding pocket [chemical binding]; other site 1246995018084 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 1246995018085 active site 1246995018086 catalytic triad [active] 1246995018087 oxyanion hole [active] 1246995018088 short chain dehydrogenase; Provisional; Region: PRK06197 1246995018089 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1246995018090 putative NAD(P) binding site [chemical binding]; other site 1246995018091 active site 1246995018092 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995018093 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995018094 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1246995018095 elongation factor Tu; Reviewed; Region: PRK12736 1246995018096 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1246995018097 G1 box; other site 1246995018098 GEF interaction site [polypeptide binding]; other site 1246995018099 GTP/Mg2+ binding site [chemical binding]; other site 1246995018100 Switch I region; other site 1246995018101 G2 box; other site 1246995018102 G3 box; other site 1246995018103 Switch II region; other site 1246995018104 G4 box; other site 1246995018105 G5 box; other site 1246995018106 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1246995018107 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1246995018108 Antibiotic Binding Site [chemical binding]; other site 1246995018109 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 1246995018110 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1246995018111 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1246995018112 active site 1246995018113 ATP binding site [chemical binding]; other site 1246995018114 substrate binding site [chemical binding]; other site 1246995018115 activation loop (A-loop); other site 1246995018116 Phosphotransferase enzyme family; Region: APH; pfam01636 1246995018117 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1246995018118 active site 1246995018119 ATP binding site [chemical binding]; other site 1246995018120 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1246995018121 GAF domain; Region: GAF; cl17456 1246995018122 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1246995018123 PAS domain; Region: PAS_9; pfam13426 1246995018124 putative active site [active] 1246995018125 heme pocket [chemical binding]; other site 1246995018126 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1246995018127 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1246995018128 dimer interface [polypeptide binding]; other site 1246995018129 phosphorylation site [posttranslational modification] 1246995018130 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995018131 ATP binding site [chemical binding]; other site 1246995018132 Mg2+ binding site [ion binding]; other site 1246995018133 G-X-G motif; other site 1246995018134 Response regulator receiver domain; Region: Response_reg; pfam00072 1246995018135 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995018136 active site 1246995018137 phosphorylation site [posttranslational modification] 1246995018138 intermolecular recognition site; other site 1246995018139 dimerization interface [polypeptide binding]; other site 1246995018140 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 1246995018141 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 1246995018142 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1246995018143 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1246995018144 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1246995018145 active site 1246995018146 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1246995018147 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1246995018148 Walker A/P-loop; other site 1246995018149 ATP binding site [chemical binding]; other site 1246995018150 Q-loop/lid; other site 1246995018151 ABC transporter signature motif; other site 1246995018152 Walker B; other site 1246995018153 D-loop; other site 1246995018154 H-loop/switch region; other site 1246995018155 OsmC-like protein; Region: OsmC; pfam02566 1246995018156 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995018157 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 1246995018158 Walker A/P-loop; other site 1246995018159 ATP binding site [chemical binding]; other site 1246995018160 Q-loop/lid; other site 1246995018161 ABC transporter signature motif; other site 1246995018162 Walker B; other site 1246995018163 D-loop; other site 1246995018164 H-loop/switch region; other site 1246995018165 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1246995018166 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 1246995018167 oligomer interface [polypeptide binding]; other site 1246995018168 metal binding site [ion binding]; metal-binding site 1246995018169 metal binding site [ion binding]; metal-binding site 1246995018170 putative Cl binding site [ion binding]; other site 1246995018171 aspartate ring; other site 1246995018172 basic sphincter; other site 1246995018173 hydrophobic gate; other site 1246995018174 periplasmic entrance; other site 1246995018175 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1246995018176 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1246995018177 putative sugar binding sites [chemical binding]; other site 1246995018178 Q-X-W motif; other site 1246995018179 Alginate lyase; Region: Alginate_lyase2; pfam08787 1246995018180 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1246995018181 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1246995018182 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1246995018183 metal ion-dependent adhesion site (MIDAS); other site 1246995018184 von Willebrand factor type A domain; Region: VWA_2; pfam13519 1246995018185 metal ion-dependent adhesion site (MIDAS); other site 1246995018186 Protein of unknown function DUF58; Region: DUF58; pfam01882 1246995018187 MoxR-like ATPases [General function prediction only]; Region: COG0714 1246995018188 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1246995018189 Walker A motif; other site 1246995018190 ATP binding site [chemical binding]; other site 1246995018191 Walker B motif; other site 1246995018192 arginine finger; other site 1246995018193 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1246995018194 Condensation domain; Region: Condensation; pfam00668 1246995018195 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1246995018196 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1246995018197 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1246995018198 acyl-activating enzyme (AAE) consensus motif; other site 1246995018199 AMP binding site [chemical binding]; other site 1246995018200 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1246995018201 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1246995018202 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 1246995018203 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 1246995018204 metal binding site [ion binding]; metal-binding site 1246995018205 putative dimer interface [polypeptide binding]; other site 1246995018206 H+ Antiporter protein; Region: 2A0121; TIGR00900 1246995018207 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 1246995018208 active site 1246995018209 catalytic residues [active] 1246995018210 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1246995018211 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1246995018212 putative sugar binding sites [chemical binding]; other site 1246995018213 Q-X-W motif; other site 1246995018214 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1246995018215 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1246995018216 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1246995018217 RHS Repeat; Region: RHS_repeat; pfam05593 1246995018218 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1246995018219 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1246995018220 protein-splicing catalytic site; other site 1246995018221 thioester formation/cholesterol transfer; other site 1246995018222 Pretoxin HINT domain; Region: PT-HINT; pfam07591 1246995018223 Putative transmembrane protein (PGPGW); Region: PGPGW; cl09870 1246995018224 Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686 1246995018225 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1246995018226 Helix-turn-helix domain; Region: HTH_18; pfam12833 1246995018227 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1246995018228 Rrf2 family protein; Region: rrf2_super; TIGR00738 1246995018229 Transcriptional regulator; Region: Rrf2; pfam02082 1246995018230 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07003 1246995018231 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1246995018232 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1246995018233 metal binding site [ion binding]; metal-binding site 1246995018234 active site 1246995018235 I-site; other site 1246995018236 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1246995018237 putative catalytic site [active] 1246995018238 putative metal binding site [ion binding]; other site 1246995018239 putative phosphate binding site [ion binding]; other site 1246995018240 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1246995018241 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1246995018242 active site 1246995018243 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1246995018244 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1246995018245 active site 1246995018246 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1246995018247 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1246995018248 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1246995018249 YndJ-like protein; Region: YndJ; pfam14158 1246995018250 Domain of unknown function (DUF1990); Region: DUF1990; pfam09348 1246995018251 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1246995018252 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1246995018253 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1246995018254 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1246995018255 Glycosyl hydrolase family 81; Region: Glyco_hydro_81; cl02310 1246995018256 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1246995018257 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 1246995018258 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1246995018259 active site 1246995018260 ATP binding site [chemical binding]; other site 1246995018261 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 1246995018262 substrate binding site [chemical binding]; other site 1246995018263 activation loop (A-loop); other site 1246995018264 Cytochrome P450; Region: p450; cl12078 1246995018265 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1246995018266 Alpha-lytic protease prodomain; Region: Pro_Al_protease; pfam02983 1246995018267 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1246995018268 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 1246995018269 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1246995018270 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1246995018271 DNA binding site [nucleotide binding] 1246995018272 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1246995018273 active site 1246995018274 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 1246995018275 dimer interface [polypeptide binding]; other site 1246995018276 non-prolyl cis peptide bond; other site 1246995018277 insertion regions; other site 1246995018278 Cupin domain; Region: Cupin_2; cl17218 1246995018279 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1246995018280 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 1246995018281 molybdopterin cofactor binding site; other site 1246995018282 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 1246995018283 molybdopterin cofactor binding site; other site 1246995018284 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1246995018285 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995018286 Walker A/P-loop; other site 1246995018287 ATP binding site [chemical binding]; other site 1246995018288 Q-loop/lid; other site 1246995018289 ABC transporter signature motif; other site 1246995018290 Walker B; other site 1246995018291 D-loop; other site 1246995018292 H-loop/switch region; other site 1246995018293 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1246995018294 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1246995018295 substrate binding pocket [chemical binding]; other site 1246995018296 membrane-bound complex binding site; other site 1246995018297 hinge residues; other site 1246995018298 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1246995018299 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995018300 dimer interface [polypeptide binding]; other site 1246995018301 conserved gate region; other site 1246995018302 ABC-ATPase subunit interface; other site 1246995018303 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1246995018304 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1246995018305 active site 1246995018306 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1246995018307 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1246995018308 dimer interface [polypeptide binding]; other site 1246995018309 active site 1246995018310 non-prolyl cis peptide bond; other site 1246995018311 insertion regions; other site 1246995018312 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1246995018313 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 1246995018314 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1246995018315 active site 1246995018316 dimer interface [polypeptide binding]; other site 1246995018317 non-prolyl cis peptide bond; other site 1246995018318 insertion regions; other site 1246995018319 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1246995018320 hypothetical protein; Provisional; Region: PRK06771 1246995018321 Homeodomain-like domain; Region: HTH_23; cl17451 1246995018322 Predicted membrane protein (DUF2238); Region: DUF2238; pfam09997 1246995018323 Na binding site [ion binding]; other site 1246995018324 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1246995018325 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 1246995018326 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 1246995018327 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995018328 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995018329 active site 1246995018330 phosphorylation site [posttranslational modification] 1246995018331 intermolecular recognition site; other site 1246995018332 dimerization interface [polypeptide binding]; other site 1246995018333 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995018334 DNA binding residues [nucleotide binding] 1246995018335 dimerization interface [polypeptide binding]; other site 1246995018336 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1246995018337 Histidine kinase; Region: HisKA_3; pfam07730 1246995018338 Domain of unknown function (DUF4281); Region: DUF4281; pfam14108 1246995018339 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 1246995018340 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1246995018341 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1246995018342 metal-binding site 1246995018343 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1246995018344 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1246995018345 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1246995018346 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1246995018347 MoxR-like ATPases [General function prediction only]; Region: COG0714 1246995018348 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1246995018349 Walker A motif; other site 1246995018350 ATP binding site [chemical binding]; other site 1246995018351 Walker B motif; other site 1246995018352 arginine finger; other site 1246995018353 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 1246995018354 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1246995018355 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1246995018356 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1246995018357 motif II; other site 1246995018358 D-cysteine desulfhydrase; Validated; Region: PRK03910 1246995018359 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1246995018360 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1246995018361 catalytic residue [active] 1246995018362 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1246995018363 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1246995018364 conserved cys residue [active] 1246995018365 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1246995018366 Isochorismatase family; Region: Isochorismatase; pfam00857 1246995018367 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1246995018368 catalytic triad [active] 1246995018369 conserved cis-peptide bond; other site 1246995018370 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1246995018371 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995018372 NAD(P) binding site [chemical binding]; other site 1246995018373 active site 1246995018374 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1246995018375 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1246995018376 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1246995018377 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1246995018378 substrate binding site [chemical binding]; other site 1246995018379 ATP binding site [chemical binding]; other site 1246995018380 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 1246995018381 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1246995018382 active site 1246995018383 intersubunit interface [polypeptide binding]; other site 1246995018384 catalytic residue [active] 1246995018385 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1246995018386 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1246995018387 putative NAD(P) binding site [chemical binding]; other site 1246995018388 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1246995018389 metal binding site [ion binding]; metal-binding site 1246995018390 active site 1246995018391 I-site; other site 1246995018392 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1246995018393 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1246995018394 amidase catalytic site [active] 1246995018395 Zn binding residues [ion binding]; other site 1246995018396 substrate binding site [chemical binding]; other site 1246995018397 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1246995018398 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1246995018399 DNA binding residues [nucleotide binding] 1246995018400 Predicted ATPase [General function prediction only]; Region: COG3903 1246995018401 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995018402 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995018403 DNA binding residues [nucleotide binding] 1246995018404 dimerization interface [polypeptide binding]; other site 1246995018405 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1246995018406 active site 1246995018407 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1246995018408 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1246995018409 putative DNA binding site [nucleotide binding]; other site 1246995018410 putative Zn2+ binding site [ion binding]; other site 1246995018411 H+ Antiporter protein; Region: 2A0121; TIGR00900 1246995018412 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1246995018413 putative substrate translocation pore; other site 1246995018414 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1246995018415 nudix motif; other site 1246995018416 TspO/MBR family; Region: TspO_MBR; pfam03073 1246995018417 hypothetical protein; Provisional; Region: PRK07236 1246995018418 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995018419 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995018420 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995018421 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1246995018422 Predicted acyl esterases [General function prediction only]; Region: COG2936 1246995018423 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 1246995018424 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1246995018425 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1246995018426 Ca binding site [ion binding]; other site 1246995018427 active site 1246995018428 catalytic site [active] 1246995018429 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1246995018430 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 1246995018431 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1246995018432 putative ADP-binding pocket [chemical binding]; other site 1246995018433 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 1246995018434 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1246995018435 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1246995018436 active site 1246995018437 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995018438 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995018439 active site 1246995018440 phosphorylation site [posttranslational modification] 1246995018441 intermolecular recognition site; other site 1246995018442 dimerization interface [polypeptide binding]; other site 1246995018443 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995018444 dimerization interface [polypeptide binding]; other site 1246995018445 DNA binding residues [nucleotide binding] 1246995018446 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 1246995018447 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1246995018448 Histidine kinase; Region: HisKA_3; pfam07730 1246995018449 hypothetical protein; Provisional; Region: PRK08317 1246995018450 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1246995018451 S-adenosylmethionine binding site [chemical binding]; other site 1246995018452 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1246995018453 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1246995018454 metal binding site [ion binding]; metal-binding site 1246995018455 active site 1246995018456 I-site; other site 1246995018457 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1246995018458 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1246995018459 metal binding site [ion binding]; metal-binding site 1246995018460 active site 1246995018461 I-site; other site 1246995018462 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1246995018463 putative oxidoreductase; Provisional; Region: PRK11579 1246995018464 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1246995018465 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1246995018466 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1246995018467 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995018468 NAD(P) binding site [chemical binding]; other site 1246995018469 active site 1246995018470 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1246995018471 active site 1246995018472 kynureninase; Region: kynureninase; TIGR01814 1246995018473 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1246995018474 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1246995018475 catalytic residue [active] 1246995018476 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 1246995018477 hypothetical protein; Provisional; Region: PRK01842 1246995018478 SEC-C motif; Region: SEC-C; pfam02810 1246995018479 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1246995018480 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1246995018481 DNA binding residues [nucleotide binding] 1246995018482 putative dimer interface [polypeptide binding]; other site 1246995018483 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1246995018484 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1246995018485 active site 1246995018486 catalytic tetrad [active] 1246995018487 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1246995018488 putative CheW interface [polypeptide binding]; other site 1246995018489 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1246995018490 sequence-specific DNA binding site [nucleotide binding]; other site 1246995018491 salt bridge; other site 1246995018492 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1246995018493 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1246995018494 DNA binding site [nucleotide binding] 1246995018495 domain linker motif; other site 1246995018496 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_10; cd06292 1246995018497 putative dimerization interface [polypeptide binding]; other site 1246995018498 putative ligand binding site [chemical binding]; other site 1246995018499 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1246995018500 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1246995018501 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1246995018502 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995018503 dimer interface [polypeptide binding]; other site 1246995018504 conserved gate region; other site 1246995018505 putative PBP binding loops; other site 1246995018506 ABC-ATPase subunit interface; other site 1246995018507 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1246995018508 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995018509 dimer interface [polypeptide binding]; other site 1246995018510 conserved gate region; other site 1246995018511 putative PBP binding loops; other site 1246995018512 ABC-ATPase subunit interface; other site 1246995018513 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 1246995018514 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1246995018515 active site 1246995018516 catalytic site [active] 1246995018517 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1246995018518 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 1246995018519 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1246995018520 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1246995018521 sugar binding site [chemical binding]; other site 1246995018522 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1246995018523 sugar binding site [chemical binding]; other site 1246995018524 Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231 1246995018525 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 1246995018526 sugar binding site [chemical binding]; other site 1246995018527 CARDB; Region: CARDB; pfam07705 1246995018528 CARDB; Region: CARDB; pfam07705 1246995018529 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 1246995018530 putative metal binding site [ion binding]; other site 1246995018531 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1246995018532 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995018533 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995018534 active site 1246995018535 phosphorylation site [posttranslational modification] 1246995018536 intermolecular recognition site; other site 1246995018537 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995018538 DNA binding residues [nucleotide binding] 1246995018539 dimerization interface [polypeptide binding]; other site 1246995018540 Histidine kinase; Region: HisKA_3; pfam07730 1246995018541 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1246995018542 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1246995018543 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1246995018544 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1246995018545 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 1246995018546 active site clefts [active] 1246995018547 zinc binding site [ion binding]; other site 1246995018548 dimer interface [polypeptide binding]; other site 1246995018549 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1246995018550 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995018551 NAD(P) binding site [chemical binding]; other site 1246995018552 active site 1246995018553 pyruvate phosphate dikinase; Provisional; Region: PRK09279 1246995018554 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1246995018555 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1246995018556 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1246995018557 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1246995018558 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1246995018559 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 1246995018560 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 1246995018561 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1246995018562 active site 1246995018563 dimer interface [polypeptide binding]; other site 1246995018564 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1246995018565 Ligand Binding Site [chemical binding]; other site 1246995018566 Molecular Tunnel; other site 1246995018567 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1246995018568 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1246995018569 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1246995018570 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1246995018571 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1246995018572 DinB superfamily; Region: DinB_2; pfam12867 1246995018573 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1246995018574 Prokaryotic RING finger family 4; Region: Prok-RING_4; pfam14447 1246995018575 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1246995018576 putative metal binding site [ion binding]; other site 1246995018577 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1246995018578 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1246995018579 ligand binding site [chemical binding]; other site 1246995018580 flexible hinge region; other site 1246995018581 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995018582 ATP binding site [chemical binding]; other site 1246995018583 Mg2+ binding site [ion binding]; other site 1246995018584 G-X-G motif; other site 1246995018585 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1246995018586 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995018587 active site 1246995018588 phosphorylation site [posttranslational modification] 1246995018589 intermolecular recognition site; other site 1246995018590 dimerization interface [polypeptide binding]; other site 1246995018591 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1246995018592 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1246995018593 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 1246995018594 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 1246995018595 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1246995018596 Predicted acetyltransferase [General function prediction only]; Region: COG2388 1246995018597 Predicted methyltransferase [General function prediction only]; Region: COG3897 1246995018598 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1246995018599 DNA-binding site [nucleotide binding]; DNA binding site 1246995018600 RNA-binding motif; other site 1246995018601 Alpha-lytic protease prodomain; Region: Pro_Al_protease; pfam02983 1246995018602 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1246995018603 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1246995018604 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1246995018605 putative sugar binding sites [chemical binding]; other site 1246995018606 Q-X-W motif; other site 1246995018607 Cellulose binding domain; Region: CBM_2; pfam00553 1246995018608 glycoside hydrolase family 64: laminaripentaose-producing, beta-1,3-glucanase (LPHase)-like; Region: GH64-LPHase-like; cd09216 1246995018609 substrate binding pocket [chemical binding]; other site 1246995018610 catalytic residues [active] 1246995018611 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1246995018612 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1246995018613 Protease prsW family; Region: PrsW-protease; pfam13367 1246995018614 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1246995018615 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1246995018616 FAD binding pocket [chemical binding]; other site 1246995018617 FAD binding motif [chemical binding]; other site 1246995018618 phosphate binding motif [ion binding]; other site 1246995018619 NAD binding pocket [chemical binding]; other site 1246995018620 Phosphotransferase enzyme family; Region: APH; pfam01636 1246995018621 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1246995018622 active site 1246995018623 ATP binding site [chemical binding]; other site 1246995018624 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1246995018625 substrate binding site [chemical binding]; other site 1246995018626 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 1246995018627 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1246995018628 DNA binding residues [nucleotide binding] 1246995018629 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 1246995018630 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1246995018631 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1246995018632 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1246995018633 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995018634 putative PBP binding loops; other site 1246995018635 ABC-ATPase subunit interface; other site 1246995018636 molybdenum ABC transporter, ATP-binding protein; Region: modC_ABC; TIGR02142 1246995018637 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995018638 Walker A/P-loop; other site 1246995018639 ATP binding site [chemical binding]; other site 1246995018640 Q-loop/lid; other site 1246995018641 ABC transporter signature motif; other site 1246995018642 Walker B; other site 1246995018643 D-loop; other site 1246995018644 H-loop/switch region; other site 1246995018645 TOBE domain; Region: TOBE; pfam03459 1246995018646 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 1246995018647 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 1246995018648 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 1246995018649 Protein of unknown function (DUF1684); Region: DUF1684; pfam07920 1246995018650 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 1246995018651 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH6; cd08260 1246995018652 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1246995018653 putative NAD(P) binding site [chemical binding]; other site 1246995018654 catalytic Zn binding site [ion binding]; other site 1246995018655 structural Zn binding site [ion binding]; other site 1246995018656 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1246995018657 Histidine kinase; Region: HisKA_3; pfam07730 1246995018658 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1246995018659 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995018660 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995018661 active site 1246995018662 phosphorylation site [posttranslational modification] 1246995018663 intermolecular recognition site; other site 1246995018664 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995018665 DNA binding residues [nucleotide binding] 1246995018666 dimerization interface [polypeptide binding]; other site 1246995018667 Predicted membrane protein (DUF2306); Region: DUF2306; cl02232 1246995018668 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1246995018669 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1246995018670 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1246995018671 RNA binding site [nucleotide binding]; other site 1246995018672 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 1246995018673 RNA binding site [nucleotide binding]; other site 1246995018674 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1246995018675 glycosyltransferase, MGT family; Region: MGT; TIGR01426 1246995018676 active site 1246995018677 TDP-binding site; other site 1246995018678 acceptor substrate-binding pocket; other site 1246995018679 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995018680 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995018681 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1246995018682 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 1246995018683 FtsX-like permease family; Region: FtsX; pfam02687 1246995018684 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1246995018685 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1246995018686 Walker A/P-loop; other site 1246995018687 ATP binding site [chemical binding]; other site 1246995018688 Q-loop/lid; other site 1246995018689 ABC transporter signature motif; other site 1246995018690 Walker B; other site 1246995018691 D-loop; other site 1246995018692 H-loop/switch region; other site 1246995018693 Predicted transcriptional regulators [Transcription]; Region: COG1695 1246995018694 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1246995018695 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1246995018696 putative DNA binding site [nucleotide binding]; other site 1246995018697 putative Zn2+ binding site [ion binding]; other site 1246995018698 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1246995018699 hydrophobic ligand binding site; other site 1246995018700 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1246995018701 Domain of unknown function (DUF4331); Region: DUF4331; pfam14224 1246995018702 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1246995018703 binding surface 1246995018704 TPR motif; other site 1246995018705 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1246995018706 TPR motif; other site 1246995018707 binding surface 1246995018708 TPR repeat; Region: TPR_11; pfam13414 1246995018709 High-affinity nickel-transport protein; Region: NicO; cl00964 1246995018710 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 1246995018711 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995018712 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995018713 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1246995018714 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1246995018715 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995018716 Walker A/P-loop; other site 1246995018717 ATP binding site [chemical binding]; other site 1246995018718 Q-loop/lid; other site 1246995018719 ABC transporter signature motif; other site 1246995018720 Walker B; other site 1246995018721 D-loop; other site 1246995018722 H-loop/switch region; other site 1246995018723 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1246995018724 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1246995018725 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1246995018726 Walker A/P-loop; other site 1246995018727 ATP binding site [chemical binding]; other site 1246995018728 Q-loop/lid; other site 1246995018729 ABC transporter signature motif; other site 1246995018730 Walker B; other site 1246995018731 D-loop; other site 1246995018732 H-loop/switch region; other site 1246995018733 Calx-beta domain; Region: Calx-beta; cl02522 1246995018734 Calx-beta domain; Region: Calx-beta; cl02522 1246995018735 Calx-beta domain; Region: Calx-beta; cl02522 1246995018736 Calx-beta domain; Region: Calx-beta; cl02522 1246995018737 TfoX N-terminal domain; Region: TfoX_N; cl17592 1246995018738 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 1246995018739 dimer interface [polypeptide binding]; other site 1246995018740 Alkaline phosphatase homologues; Region: alkPPc; smart00098 1246995018741 active site 1246995018742 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1246995018743 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1246995018744 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 1246995018745 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 1246995018746 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 1246995018747 SLBB domain; Region: SLBB; pfam10531 1246995018748 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 1246995018749 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 1246995018750 ApbE family; Region: ApbE; pfam02424 1246995018751 AAA ATPase domain; Region: AAA_16; pfam13191 1246995018752 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995018753 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995018754 DNA binding residues [nucleotide binding] 1246995018755 dimerization interface [polypeptide binding]; other site 1246995018756 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1246995018757 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995018758 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995018759 active site 1246995018760 phosphorylation site [posttranslational modification] 1246995018761 intermolecular recognition site; other site 1246995018762 dimerization interface [polypeptide binding]; other site 1246995018763 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995018764 DNA binding residues [nucleotide binding] 1246995018765 dimerization interface [polypeptide binding]; other site 1246995018766 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1246995018767 Histidine kinase; Region: HisKA_3; pfam07730 1246995018768 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995018769 ATP binding site [chemical binding]; other site 1246995018770 G-X-G motif; other site 1246995018771 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1246995018772 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1246995018773 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1246995018774 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1246995018775 Walker A/P-loop; other site 1246995018776 ATP binding site [chemical binding]; other site 1246995018777 Q-loop/lid; other site 1246995018778 ABC transporter signature motif; other site 1246995018779 Walker B; other site 1246995018780 D-loop; other site 1246995018781 H-loop/switch region; other site 1246995018782 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1246995018783 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1246995018784 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1246995018785 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1246995018786 Walker A/P-loop; other site 1246995018787 ATP binding site [chemical binding]; other site 1246995018788 Q-loop/lid; other site 1246995018789 ABC transporter signature motif; other site 1246995018790 Walker B; other site 1246995018791 D-loop; other site 1246995018792 H-loop/switch region; other site 1246995018793 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1246995018794 RNA/DNA hybrid binding site [nucleotide binding]; other site 1246995018795 active site 1246995018796 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1246995018797 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1246995018798 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1246995018799 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1246995018800 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1246995018801 TIGR03086 family protein; Region: TIGR03086 1246995018802 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1246995018803 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1246995018804 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1246995018805 Epoxide hydrolase N terminus; Region: EHN; pfam06441 1246995018806 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1246995018807 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1246995018808 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 1246995018809 aromatic arch; other site 1246995018810 DCoH dimer interaction site [polypeptide binding]; other site 1246995018811 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1246995018812 DCoH tetramer interaction site [polypeptide binding]; other site 1246995018813 substrate binding site [chemical binding]; other site 1246995018814 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 1246995018815 Protein of unknown function (DUF419); Region: DUF419; cl15265 1246995018816 AAA ATPase domain; Region: AAA_16; pfam13191 1246995018817 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995018818 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995018819 DNA binding residues [nucleotide binding] 1246995018820 dimerization interface [polypeptide binding]; other site 1246995018821 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 1246995018822 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 1246995018823 putative active site [active] 1246995018824 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1246995018825 Domain of unknown function (DUF1932); Region: DUF1932; pfam09130 1246995018826 Helix-turn-helix domain; Region: HTH_20; pfam12840 1246995018827 putative DNA binding site [nucleotide binding]; other site 1246995018828 H+ Antiporter protein; Region: 2A0121; TIGR00900 1246995018829 radical SAM/SPASM domain, FxsB family; Region: SAM_SPASM_FxsB; TIGR04269 1246995018830 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1246995018831 FeS/SAM binding site; other site 1246995018832 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 1246995018833 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 1246995018834 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1246995018835 DNA binding residues [nucleotide binding] 1246995018836 drug binding residues [chemical binding]; other site 1246995018837 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1246995018838 active site 1246995018839 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1246995018840 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1246995018841 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1246995018842 DNA binding site [nucleotide binding] 1246995018843 domain linker motif; other site 1246995018844 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1246995018845 dimerization interface [polypeptide binding]; other site 1246995018846 ligand binding site [chemical binding]; other site 1246995018847 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 1246995018848 nucleotide binding site [chemical binding]; other site 1246995018849 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1246995018850 Histidine kinase; Region: HisKA_3; pfam07730 1246995018851 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995018852 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995018853 active site 1246995018854 phosphorylation site [posttranslational modification] 1246995018855 intermolecular recognition site; other site 1246995018856 dimerization interface [polypeptide binding]; other site 1246995018857 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995018858 DNA binding residues [nucleotide binding] 1246995018859 dimerization interface [polypeptide binding]; other site 1246995018860 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 1246995018861 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 1246995018862 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1246995018863 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1246995018864 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 1246995018865 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 1246995018866 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 1246995018867 PAS domain S-box; Region: sensory_box; TIGR00229 1246995018868 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1246995018869 putative active site [active] 1246995018870 heme pocket [chemical binding]; other site 1246995018871 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1246995018872 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1246995018873 metal binding site [ion binding]; metal-binding site 1246995018874 active site 1246995018875 I-site; other site 1246995018876 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1246995018877 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1246995018878 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 1246995018879 dimer interface [polypeptide binding]; other site 1246995018880 active site 1246995018881 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1246995018882 catalytic residues [active] 1246995018883 substrate binding site [chemical binding]; other site 1246995018884 2-acyl-glycerophospho-ethanolamine acyltransferase; Validated; Region: PRK08633 1246995018885 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1246995018886 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 1246995018887 Zn binding site [ion binding]; other site 1246995018888 Protein of unknown function DUF72; Region: DUF72; pfam01904 1246995018889 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1246995018890 dimerization interface [polypeptide binding]; other site 1246995018891 putative DNA binding site [nucleotide binding]; other site 1246995018892 putative Zn2+ binding site [ion binding]; other site 1246995018893 Dienelactone hydrolase family; Region: DLH; pfam01738 1246995018894 Electron transfer DM13; Region: DM13; pfam10517 1246995018895 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 1246995018896 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 1246995018897 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1246995018898 S-adenosylmethionine binding site [chemical binding]; other site 1246995018899 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 1246995018900 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1246995018901 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1246995018902 S-adenosylmethionine binding site [chemical binding]; other site 1246995018903 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 1246995018904 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 1246995018905 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1246995018906 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1246995018907 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1246995018908 nucleophilic elbow; other site 1246995018909 catalytic triad; other site 1246995018910 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1246995018911 sugar binding site [chemical binding]; other site 1246995018912 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1246995018913 sugar binding site [chemical binding]; other site 1246995018914 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 1246995018915 active site 1246995018916 catalytic residues [active] 1246995018917 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1246995018918 sugar binding site [chemical binding]; other site 1246995018919 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 1246995018920 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1246995018921 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1246995018922 DNA binding site [nucleotide binding] 1246995018923 domain linker motif; other site 1246995018924 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 1246995018925 putative dimerization interface [polypeptide binding]; other site 1246995018926 putative ligand binding site [chemical binding]; other site 1246995018927 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1246995018928 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1246995018929 NAD(P) binding site [chemical binding]; other site 1246995018930 putative active site [active] 1246995018931 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1246995018932 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1246995018933 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1246995018934 DNA binding residues [nucleotide binding] 1246995018935 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 1246995018936 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1246995018937 substrate binding site [chemical binding]; other site 1246995018938 ATP binding site [chemical binding]; other site 1246995018939 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1246995018940 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1246995018941 substrate binding site [chemical binding]; other site 1246995018942 ATP binding site [chemical binding]; other site 1246995018943 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 1246995018944 Class I aldolases; Region: Aldolase_Class_I; cl17187 1246995018945 catalytic residue [active] 1246995018946 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 1246995018947 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1246995018948 putative ligand binding site [chemical binding]; other site 1246995018949 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1246995018950 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1246995018951 TM-ABC transporter signature motif; other site 1246995018952 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1246995018953 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995018954 Walker A/P-loop; other site 1246995018955 ATP binding site [chemical binding]; other site 1246995018956 Q-loop/lid; other site 1246995018957 ABC transporter signature motif; other site 1246995018958 Walker B; other site 1246995018959 D-loop; other site 1246995018960 H-loop/switch region; other site 1246995018961 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1246995018962 FAD binding domain; Region: FAD_binding_4; pfam01565 1246995018963 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 1246995018964 DNA-binding site [nucleotide binding]; DNA binding site 1246995018965 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1246995018966 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1246995018967 Coenzyme A binding pocket [chemical binding]; other site 1246995018968 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1246995018969 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1246995018970 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1246995018971 glycoside hydrolase family 64: laminaripentaose-producing, beta-1,3-glucanase (LPHase)-like; Region: GH64-LPHase-like; cd09216 1246995018972 substrate binding pocket [chemical binding]; other site 1246995018973 catalytic residues [active] 1246995018974 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 1246995018975 metal binding site [ion binding]; metal-binding site 1246995018976 ligand binding site [chemical binding]; other site 1246995018977 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1246995018978 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1246995018979 putative dimer interface [polypeptide binding]; other site 1246995018980 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 1246995018981 DNA polymerase IV; Validated; Region: PRK03858 1246995018982 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1246995018983 active site 1246995018984 DNA binding site [nucleotide binding] 1246995018985 Histidine kinase; Region: HisKA_3; pfam07730 1246995018986 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995018987 ATP binding site [chemical binding]; other site 1246995018988 Mg2+ binding site [ion binding]; other site 1246995018989 G-X-G motif; other site 1246995018990 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995018991 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995018992 active site 1246995018993 phosphorylation site [posttranslational modification] 1246995018994 intermolecular recognition site; other site 1246995018995 dimerization interface [polypeptide binding]; other site 1246995018996 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995018997 DNA binding residues [nucleotide binding] 1246995018998 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 1246995018999 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1246995019000 putative DNA binding site [nucleotide binding]; other site 1246995019001 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1246995019002 putative Zn2+ binding site [ion binding]; other site 1246995019003 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1246995019004 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1246995019005 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cl00364 1246995019006 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 1246995019007 active site 1246995019008 SAM binding site [chemical binding]; other site 1246995019009 homodimer interface [polypeptide binding]; other site 1246995019010 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 1246995019011 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1246995019012 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1246995019013 precorrin-3B synthase; Region: CobG; TIGR02435 1246995019014 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1246995019015 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1246995019016 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 1246995019017 Precorrin-8X methylmutase; Region: CbiC; pfam02570 1246995019018 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 1246995019019 active site 1246995019020 SAM binding site [chemical binding]; other site 1246995019021 homodimer interface [polypeptide binding]; other site 1246995019022 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 1246995019023 active site 1246995019024 SAM binding site [chemical binding]; other site 1246995019025 homodimer interface [polypeptide binding]; other site 1246995019026 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 1246995019027 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 1246995019028 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 1246995019029 active site 1246995019030 SAM binding site [chemical binding]; other site 1246995019031 homodimer interface [polypeptide binding]; other site 1246995019032 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 1246995019033 active site 1246995019034 putative homodimer interface [polypeptide binding]; other site 1246995019035 SAM binding site [chemical binding]; other site 1246995019036 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 1246995019037 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1246995019038 S-adenosylmethionine binding site [chemical binding]; other site 1246995019039 Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097 1246995019040 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 1246995019041 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 1246995019042 FAD binding pocket [chemical binding]; other site 1246995019043 FAD binding motif [chemical binding]; other site 1246995019044 phosphate binding motif [ion binding]; other site 1246995019045 beta-alpha-beta structure motif; other site 1246995019046 NAD binding pocket [chemical binding]; other site 1246995019047 FMN-binding domain; Region: FMN_bind; pfam04205 1246995019048 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 1246995019049 ApbE family; Region: ApbE; pfam02424 1246995019050 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 1246995019051 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1246995019052 Coenzyme A binding pocket [chemical binding]; other site 1246995019053 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1246995019054 DNA binding site [nucleotide binding] 1246995019055 active site 1246995019056 Int/Topo IB signature motif; other site 1246995019057 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 1246995019058 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995019059 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995019060 active site 1246995019061 phosphorylation site [posttranslational modification] 1246995019062 intermolecular recognition site; other site 1246995019063 dimerization interface [polypeptide binding]; other site 1246995019064 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995019065 DNA binding residues [nucleotide binding] 1246995019066 dimerization interface [polypeptide binding]; other site 1246995019067 Copper type II ascorbate-dependent monooxygenase, C-terminal domain; Region: Cu2_monoox_C; pfam03712 1246995019068 MMPL family; Region: MMPL; pfam03176 1246995019069 MMPL family; Region: MMPL; pfam03176 1246995019070 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1246995019071 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1246995019072 Coenzyme A binding pocket [chemical binding]; other site 1246995019073 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1246995019074 [4Fe-4S] binding site [ion binding]; other site 1246995019075 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 1246995019076 molybdopterin cofactor binding site; other site 1246995019077 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 1246995019078 molybdopterin cofactor binding site; other site 1246995019079 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1246995019080 active site 1246995019081 catalytic residues [active] 1246995019082 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 1246995019083 signature motif; other site 1246995019084 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 1246995019085 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 1246995019086 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1246995019087 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1246995019088 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 1246995019089 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995019090 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1246995019091 DNA binding residues [nucleotide binding] 1246995019092 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1246995019093 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995019094 active site 1246995019095 phosphorylation site [posttranslational modification] 1246995019096 intermolecular recognition site; other site 1246995019097 dimerization interface [polypeptide binding]; other site 1246995019098 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1246995019099 DNA binding site [nucleotide binding] 1246995019100 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1246995019101 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1246995019102 dimerization interface [polypeptide binding]; other site 1246995019103 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1246995019104 dimer interface [polypeptide binding]; other site 1246995019105 phosphorylation site [posttranslational modification] 1246995019106 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995019107 ATP binding site [chemical binding]; other site 1246995019108 Mg2+ binding site [ion binding]; other site 1246995019109 G-X-G motif; other site 1246995019110 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1246995019111 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1246995019112 Predicted transcriptional regulators [Transcription]; Region: COG1733 1246995019113 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1246995019114 Family description; Region: VCBS; pfam13517 1246995019115 Family description; Region: VCBS; pfam13517 1246995019116 Family description; Region: VCBS; pfam13517 1246995019117 Family description; Region: VCBS; pfam13517 1246995019118 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1246995019119 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1246995019120 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1246995019121 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1246995019122 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 1246995019123 conserved cys residue [active] 1246995019124 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1246995019125 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1246995019126 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1246995019127 active site 1246995019128 metal binding site [ion binding]; metal-binding site 1246995019129 I-site; other site 1246995019130 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1246995019131 Predicted ATPase [General function prediction only]; Region: COG3899 1246995019132 AAA ATPase domain; Region: AAA_16; pfam13191 1246995019133 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995019134 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995019135 DNA binding residues [nucleotide binding] 1246995019136 dimerization interface [polypeptide binding]; other site 1246995019137 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 1246995019138 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 1246995019139 active site 1246995019140 catalytic site [active] 1246995019141 Carbohydrate Binding Module family 35 (CBM35), pectate lyase-like; appended mainly to enzymes that bind mannan (Man), xylan, glucuronic acid (GlcA) and possibly glucans; Region: CBM35_pectate_lyase-like; cd04082 1246995019142 Ca binding site [ion binding]; other site 1246995019143 Ca binding site (active) [ion binding]; other site 1246995019144 ligand binding site [chemical binding]; other site 1246995019145 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1246995019146 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1246995019147 Walker A/P-loop; other site 1246995019148 ATP binding site [chemical binding]; other site 1246995019149 Q-loop/lid; other site 1246995019150 ABC transporter signature motif; other site 1246995019151 Walker B; other site 1246995019152 D-loop; other site 1246995019153 H-loop/switch region; other site 1246995019154 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1246995019155 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1246995019156 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1246995019157 Histidine kinase; Region: HisKA_3; pfam07730 1246995019158 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1246995019159 ATP binding site [chemical binding]; other site 1246995019160 Mg2+ binding site [ion binding]; other site 1246995019161 G-X-G motif; other site 1246995019162 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995019163 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995019164 active site 1246995019165 phosphorylation site [posttranslational modification] 1246995019166 intermolecular recognition site; other site 1246995019167 dimerization interface [polypeptide binding]; other site 1246995019168 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995019169 DNA binding residues [nucleotide binding] 1246995019170 dimerization interface [polypeptide binding]; other site 1246995019171 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 1246995019172 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1246995019173 S-adenosylmethionine binding site [chemical binding]; other site 1246995019174 CAAX protease self-immunity; Region: Abi; pfam02517 1246995019175 Histidine kinase; Region: HisKA_3; pfam07730 1246995019176 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995019177 ATP binding site [chemical binding]; other site 1246995019178 Mg2+ binding site [ion binding]; other site 1246995019179 G-X-G motif; other site 1246995019180 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995019181 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995019182 active site 1246995019183 phosphorylation site [posttranslational modification] 1246995019184 intermolecular recognition site; other site 1246995019185 dimerization interface [polypeptide binding]; other site 1246995019186 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995019187 DNA binding residues [nucleotide binding] 1246995019188 dimerization interface [polypeptide binding]; other site 1246995019189 Necrosis inducing protein (NPP1); Region: NPP1; pfam05630 1246995019190 Putative amidase domain; Region: Amidase_6; pfam12671 1246995019191 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1246995019192 LexA repressor; Validated; Region: PRK00215 1246995019193 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1246995019194 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1246995019195 Catalytic site [active] 1246995019196 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1246995019197 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1246995019198 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1246995019199 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1246995019200 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508 1246995019201 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1246995019202 carboxyltransferase (CT) interaction site; other site 1246995019203 biotinylation site [posttranslational modification]; other site 1246995019204 Acetyl-CoA carboxylase, central region; Region: ACC_central; pfam08326 1246995019205 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1246995019206 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1246995019207 Beta-lactamase; Region: Beta-lactamase; pfam00144 1246995019208 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1246995019209 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 1246995019210 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995019211 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1246995019212 DNA binding residues [nucleotide binding] 1246995019213 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1246995019214 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1246995019215 active site 1246995019216 ATP binding site [chemical binding]; other site 1246995019217 substrate binding site [chemical binding]; other site 1246995019218 activation loop (A-loop); other site 1246995019219 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1246995019220 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995019221 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1246995019222 DNA binding residues [nucleotide binding] 1246995019223 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 1246995019224 Putative esterase; Region: Esterase; pfam00756 1246995019225 NMT1/THI5 like; Region: NMT1; pfam09084 1246995019226 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1246995019227 membrane-bound complex binding site; other site 1246995019228 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1246995019229 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995019230 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1246995019231 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 1246995019232 ligand binding site [chemical binding]; other site 1246995019233 metal binding site [ion binding]; metal-binding site 1246995019234 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 1246995019235 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 1246995019236 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1246995019237 DNA-binding site [nucleotide binding]; DNA binding site 1246995019238 FCD domain; Region: FCD; pfam07729 1246995019239 allophanate hydrolase; Provisional; Region: PRK08186 1246995019240 Amidase; Region: Amidase; cl11426 1246995019241 Isochorismatase family; Region: Isochorismatase; pfam00857 1246995019242 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1246995019243 catalytic triad [active] 1246995019244 conserved cis-peptide bond; other site 1246995019245 Isochorismatase family; Region: Isochorismatase; pfam00857 1246995019246 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1246995019247 catalytic triad [active] 1246995019248 conserved cis-peptide bond; other site 1246995019249 Protein of unknown function (DUF3225); Region: DUF3225; pfam11533 1246995019250 SnoaL-like domain; Region: SnoaL_3; pfam13474 1246995019251 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1246995019252 hypothetical protein; Provisional; Region: PRK07236 1246995019253 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1246995019254 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1246995019255 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995019256 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1246995019257 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1246995019258 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1246995019259 substrate binding site [chemical binding]; other site 1246995019260 ATP binding site [chemical binding]; other site 1246995019261 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1246995019262 Beta-lactamase; Region: Beta-lactamase; pfam00144 1246995019263 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 1246995019264 active site 1246995019265 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102 1246995019266 IPT/TIG domain; Region: TIG; pfam01833 1246995019267 IPT/TIG domain; Region: TIG; pfam01833 1246995019268 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 1246995019269 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1246995019270 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1246995019271 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1246995019272 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1246995019273 active site 1246995019274 catalytic tetrad [active] 1246995019275 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1246995019276 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 1246995019277 DNA binding residues [nucleotide binding] 1246995019278 putative dimer interface [polypeptide binding]; other site 1246995019279 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1246995019280 catalytic residues [active] 1246995019281 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 1246995019282 active site clefts [active] 1246995019283 zinc binding site [ion binding]; other site 1246995019284 dimer interface [polypeptide binding]; other site 1246995019285 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1246995019286 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1246995019287 metal binding site [ion binding]; metal-binding site 1246995019288 active site 1246995019289 I-site; other site 1246995019290 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1246995019291 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1246995019292 Walker A/P-loop; other site 1246995019293 ATP binding site [chemical binding]; other site 1246995019294 Q-loop/lid; other site 1246995019295 ABC transporter signature motif; other site 1246995019296 Walker B; other site 1246995019297 D-loop; other site 1246995019298 H-loop/switch region; other site 1246995019299 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1246995019300 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1246995019301 Walker A/P-loop; other site 1246995019302 ATP binding site [chemical binding]; other site 1246995019303 Q-loop/lid; other site 1246995019304 ABC transporter signature motif; other site 1246995019305 Walker B; other site 1246995019306 D-loop; other site 1246995019307 H-loop/switch region; other site 1246995019308 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1246995019309 DNA binding residues [nucleotide binding] 1246995019310 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1246995019311 dimer interface [polypeptide binding]; other site 1246995019312 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995019313 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995019314 oxidoreductase; Provisional; Region: PRK06196 1246995019315 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1246995019316 putative NAD(P) binding site [chemical binding]; other site 1246995019317 active site 1246995019318 Uncharacterized bacterial family of heme peroxidases; Region: An_peroxidase_bacterial_1; cd09819 1246995019319 putative heme binding site [chemical binding]; other site 1246995019320 putative substrate binding site [chemical binding]; other site 1246995019321 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 1246995019322 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 1246995019323 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1246995019324 potential frameshift: common BLAST hit: gi|386850606|ref|YP_006268619.1| elongation factor G 1246995019325 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1246995019326 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 1246995019327 calcium binding site 2 [ion binding]; other site 1246995019328 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1246995019329 active site 1246995019330 catalytic triad [active] 1246995019331 calcium binding site 1 [ion binding]; other site 1246995019332 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 1246995019333 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1246995019334 active site 1246995019335 catalytic residues [active] 1246995019336 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 1246995019337 nucleotide binding site [chemical binding]; other site 1246995019338 PAS domain S-box; Region: sensory_box; TIGR00229 1246995019339 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1246995019340 putative active site [active] 1246995019341 heme pocket [chemical binding]; other site 1246995019342 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1246995019343 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1246995019344 active site 1246995019345 I-site; other site 1246995019346 metal binding site [ion binding]; metal-binding site 1246995019347 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 1246995019348 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1246995019349 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1246995019350 Walker A/P-loop; other site 1246995019351 ATP binding site [chemical binding]; other site 1246995019352 Q-loop/lid; other site 1246995019353 ABC transporter signature motif; other site 1246995019354 Walker B; other site 1246995019355 D-loop; other site 1246995019356 H-loop/switch region; other site 1246995019357 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1246995019358 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995019359 dimer interface [polypeptide binding]; other site 1246995019360 conserved gate region; other site 1246995019361 ABC-ATPase subunit interface; other site 1246995019362 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 1246995019363 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1246995019364 agmatinase; Region: agmatinase; TIGR01230 1246995019365 Agmatinase-like family; Region: Agmatinase-like; cd09990 1246995019366 active site 1246995019367 oligomer interface [polypeptide binding]; other site 1246995019368 Mn binding site [ion binding]; other site 1246995019369 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1246995019370 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 1246995019371 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995019372 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995019373 active site 1246995019374 phosphorylation site [posttranslational modification] 1246995019375 intermolecular recognition site; other site 1246995019376 dimerization interface [polypeptide binding]; other site 1246995019377 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995019378 DNA binding residues [nucleotide binding] 1246995019379 Putative sensor; Region: Sensor; pfam13796 1246995019380 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1246995019381 Histidine kinase; Region: HisKA_3; pfam07730 1246995019382 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995019383 ATP binding site [chemical binding]; other site 1246995019384 Mg2+ binding site [ion binding]; other site 1246995019385 G-X-G motif; other site 1246995019386 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1246995019387 putative di-iron ligands [ion binding]; other site 1246995019388 short chain dehydrogenase; Provisional; Region: PRK06125 1246995019389 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995019390 NAD(P) binding site [chemical binding]; other site 1246995019391 active site 1246995019392 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 1246995019393 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1246995019394 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1246995019395 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1246995019396 Mg++ binding site [ion binding]; other site 1246995019397 putative catalytic motif [active] 1246995019398 putative substrate binding site [chemical binding]; other site 1246995019399 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1246995019400 active site 1246995019401 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1246995019402 active site 1246995019403 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995019404 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995019405 active site 1246995019406 phosphorylation site [posttranslational modification] 1246995019407 intermolecular recognition site; other site 1246995019408 dimerization interface [polypeptide binding]; other site 1246995019409 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995019410 DNA binding residues [nucleotide binding] 1246995019411 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1246995019412 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1246995019413 ATP binding site [chemical binding]; other site 1246995019414 Mg2+ binding site [ion binding]; other site 1246995019415 G-X-G motif; other site 1246995019416 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 1246995019417 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1246995019418 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 1246995019419 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1246995019420 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1246995019421 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1246995019422 acyl-activating enzyme (AAE) consensus motif; other site 1246995019423 AMP binding site [chemical binding]; other site 1246995019424 active site 1246995019425 CoA binding site [chemical binding]; other site 1246995019426 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cd00413 1246995019427 active site 1246995019428 catalytic residues [active] 1246995019429 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1246995019430 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995019431 dimer interface [polypeptide binding]; other site 1246995019432 ABC-ATPase subunit interface; other site 1246995019433 putative PBP binding loops; other site 1246995019434 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995019435 putative PBP binding loops; other site 1246995019436 dimer interface [polypeptide binding]; other site 1246995019437 ABC-ATPase subunit interface; other site 1246995019438 carbohydrate ABC transporter, N-acetylglucosamine/diacetylchitobiose-binding protein; Region: chitin_NgcE; TIGR03851 1246995019439 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1246995019440 hypothetical protein; Provisional; Region: PRK02947 1246995019441 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1246995019442 putative active site [active] 1246995019443 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1246995019444 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1246995019445 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1246995019446 putative active site [active] 1246995019447 AMP-binding domain protein; Validated; Region: PRK08315 1246995019448 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1246995019449 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 1246995019450 acyl-activating enzyme (AAE) consensus motif; other site 1246995019451 putative AMP binding site [chemical binding]; other site 1246995019452 putative active site [active] 1246995019453 putative CoA binding site [chemical binding]; other site 1246995019454 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1246995019455 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1246995019456 DNA binding site [nucleotide binding] 1246995019457 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1246995019458 ligand binding site [chemical binding]; other site 1246995019459 dimerization interface [polypeptide binding]; other site 1246995019460 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 1246995019461 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1246995019462 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1246995019463 DNA binding site [nucleotide binding] 1246995019464 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1246995019465 ligand binding site [chemical binding]; other site 1246995019466 dimerization interface [polypeptide binding]; other site 1246995019467 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1246995019468 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1246995019469 NAD(P) binding site [chemical binding]; other site 1246995019470 Domain of unknown function (DUF4253); Region: DUF4253; pfam14062 1246995019471 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1246995019472 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1246995019473 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1246995019474 Glycosyl hydrolase family 12; Region: Glyco_hydro_12; cl03302 1246995019475 Cellulose binding domain; Region: CBM_2; pfam00553 1246995019476 Lsr2; Region: Lsr2; pfam11774 1246995019477 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1246995019478 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995019479 NAD(P) binding site [chemical binding]; other site 1246995019480 active site 1246995019481 DDE superfamily endonuclease; Region: DDE_5; pfam13546 1246995019482 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1246995019483 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1246995019484 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1246995019485 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 1246995019486 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 1246995019487 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1246995019488 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1246995019489 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995019490 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1246995019491 NAD(P) binding site [chemical binding]; other site 1246995019492 active site 1246995019493 PAS domain S-box; Region: sensory_box; TIGR00229 1246995019494 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1246995019495 putative active site [active] 1246995019496 heme pocket [chemical binding]; other site 1246995019497 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1246995019498 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1246995019499 metal binding site [ion binding]; metal-binding site 1246995019500 active site 1246995019501 I-site; other site 1246995019502 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1246995019503 Predicted methyltransferase [General function prediction only]; Region: COG3897 1246995019504 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 1246995019505 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 1246995019506 putative active site [active] 1246995019507 hypothetical protein; Provisional; Region: PRK05463 1246995019508 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1246995019509 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 1246995019510 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 1246995019511 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 1246995019512 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1246995019513 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1246995019514 DNA-binding site [nucleotide binding]; DNA binding site 1246995019515 FCD domain; Region: FCD; pfam07729 1246995019516 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1246995019517 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1246995019518 motif II; other site 1246995019519 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1246995019520 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1246995019521 minor groove reading motif; other site 1246995019522 helix-hairpin-helix signature motif; other site 1246995019523 active site 1246995019524 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 1246995019525 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 1246995019526 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 1246995019527 Putative zinc-finger; Region: zf-HC2; pfam13490 1246995019528 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 1246995019529 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995019530 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1246995019531 DNA binding residues [nucleotide binding] 1246995019532 SnoaL-like domain; Region: SnoaL_2; pfam12680 1246995019533 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1246995019534 putative hydrophobic ligand binding site [chemical binding]; other site 1246995019535 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1246995019536 putative DNA binding site [nucleotide binding]; other site 1246995019537 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2380 1246995019538 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995019539 AAA domain; Region: AAA_23; pfam13476 1246995019540 Walker A/P-loop; other site 1246995019541 ATP binding site [chemical binding]; other site 1246995019542 Q-loop/lid; other site 1246995019543 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1246995019544 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995019545 ABC transporter signature motif; other site 1246995019546 Walker B; other site 1246995019547 D-loop; other site 1246995019548 H-loop/switch region; other site 1246995019549 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1246995019550 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1246995019551 active site 1246995019552 metal binding site [ion binding]; metal-binding site 1246995019553 DNA binding site [nucleotide binding] 1246995019554 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1246995019555 HerA helicase [Replication, recombination, and repair]; Region: COG0433 1246995019556 hypothetical protein; Provisional; Region: PRK14059 1246995019557 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 1246995019558 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1246995019559 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1246995019560 DNA binding site [nucleotide binding] 1246995019561 domain linker motif; other site 1246995019562 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 1246995019563 putative dimerization interface [polypeptide binding]; other site 1246995019564 putative ligand binding site [chemical binding]; other site 1246995019565 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1246995019566 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cd02116 1246995019567 biotin synthase; Validated; Region: PRK06256 1246995019568 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1246995019569 FeS/SAM binding site; other site 1246995019570 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1246995019571 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 1246995019572 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 1246995019573 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1246995019574 catalytic residue [active] 1246995019575 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1246995019576 AAA domain; Region: AAA_26; pfam13500 1246995019577 putative acetyltransferase; Provisional; Region: PRK03624 1246995019578 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1246995019579 Coenzyme A binding pocket [chemical binding]; other site 1246995019580 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1246995019581 Domain of unknown function DUF21; Region: DUF21; pfam01595 1246995019582 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1246995019583 Transporter associated domain; Region: CorC_HlyC; smart01091 1246995019584 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1246995019585 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1246995019586 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1246995019587 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1246995019588 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1246995019589 substrate binding site [chemical binding]; other site 1246995019590 ATP binding site [chemical binding]; other site 1246995019591 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1246995019592 GAF domain; Region: GAF; pfam01590 1246995019593 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1246995019594 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1246995019595 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1246995019596 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1246995019597 Tubby C 2; Region: Tub_2; cl02043 1246995019598 dGTP triphosphohydrolase [Nucleotide transport and metabolism]; Region: Dgt; COG0232 1246995019599 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1246995019600 Zn2+ binding site [ion binding]; other site 1246995019601 Mg2+ binding site [ion binding]; other site 1246995019602 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1246995019603 Actin-Fragmin Kinase (AFK); catalytic domain. The AFK catalytic domain is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, aminoglycoside...; Region: AFK; cl07713 1246995019604 ATP binding site [chemical binding]; other site 1246995019605 Protein of unknown function (DUF3037); Region: DUF3037; pfam11236 1246995019606 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1246995019607 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995019608 NAD(P) binding site [chemical binding]; other site 1246995019609 active site 1246995019610 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 1246995019611 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 1246995019612 active site 1246995019613 DNA binding site [nucleotide binding] 1246995019614 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 1246995019615 DNA binding site [nucleotide binding] 1246995019616 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1246995019617 TAP-like protein; Region: Abhydrolase_4; pfam08386 1246995019618 Ion channel; Region: Ion_trans_2; pfam07885 1246995019619 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1246995019620 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1246995019621 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1246995019622 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1246995019623 Walker A/P-loop; other site 1246995019624 ATP binding site [chemical binding]; other site 1246995019625 Q-loop/lid; other site 1246995019626 ABC transporter signature motif; other site 1246995019627 Walker B; other site 1246995019628 D-loop; other site 1246995019629 H-loop/switch region; other site 1246995019630 Histidine kinase; Region: HisKA_3; pfam07730 1246995019631 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1246995019632 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995019633 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995019634 active site 1246995019635 phosphorylation site [posttranslational modification] 1246995019636 intermolecular recognition site; other site 1246995019637 dimerization interface [polypeptide binding]; other site 1246995019638 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995019639 DNA binding residues [nucleotide binding] 1246995019640 dimerization interface [polypeptide binding]; other site 1246995019641 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1246995019642 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1246995019643 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1246995019644 dimerization interface [polypeptide binding]; other site 1246995019645 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1246995019646 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1246995019647 putative NAD(P) binding site [chemical binding]; other site 1246995019648 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 1246995019649 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 1246995019650 nucleotide binding site [chemical binding]; other site 1246995019651 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1246995019652 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 1246995019653 SelR domain; Region: SelR; pfam01641 1246995019654 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1246995019655 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1246995019656 folate binding site [chemical binding]; other site 1246995019657 NADP+ binding site [chemical binding]; other site 1246995019658 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1246995019659 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1246995019660 dimerization interface [polypeptide binding]; other site 1246995019661 active site 1246995019662 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1246995019663 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1246995019664 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1246995019665 N-terminal Early set domain associated with the catalytic domain of isoamylase-like (also called glycogen 6-glucanohydrolase) proteins; Region: E_set_Isoamylase_like_N; cd07184 1246995019666 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1246995019667 Coenzyme A binding pocket [chemical binding]; other site 1246995019668 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 1246995019669 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1246995019670 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1246995019671 substrate binding site [chemical binding]; other site 1246995019672 active site 1246995019673 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 1246995019674 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1246995019675 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1246995019676 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 1246995019677 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1246995019678 catalytic site [active] 1246995019679 putative active site [active] 1246995019680 putative substrate binding site [chemical binding]; other site 1246995019681 HRDC domain; Region: HRDC; cl02578 1246995019682 Uncharacterized protein conserved in archaea [Function unknown]; Region: COG4034 1246995019683 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1246995019684 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 1246995019685 dimer interface [polypeptide binding]; other site 1246995019686 active site 1246995019687 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1246995019688 substrate binding site [chemical binding]; other site 1246995019689 fatty oxidation complex, alpha subunit FadJ; Region: FadJ; TIGR02440 1246995019690 oxyanion hole (OAH) forming residues; other site 1246995019691 trimer interface [polypeptide binding]; other site 1246995019692 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1246995019693 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1246995019694 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1246995019695 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1246995019696 dimerization interface [polypeptide binding]; other site 1246995019697 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1246995019698 dimer interface [polypeptide binding]; other site 1246995019699 phosphorylation site [posttranslational modification] 1246995019700 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995019701 ATP binding site [chemical binding]; other site 1246995019702 Mg2+ binding site [ion binding]; other site 1246995019703 G-X-G motif; other site 1246995019704 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1246995019705 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995019706 active site 1246995019707 phosphorylation site [posttranslational modification] 1246995019708 intermolecular recognition site; other site 1246995019709 dimerization interface [polypeptide binding]; other site 1246995019710 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1246995019711 DNA binding site [nucleotide binding] 1246995019712 PQQ-like domain; Region: PQQ_2; pfam13360 1246995019713 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1246995019714 Trp docking motif [polypeptide binding]; other site 1246995019715 active site 1246995019716 PQQ-like domain; Region: PQQ_2; pfam13360 1246995019717 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1246995019718 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1246995019719 TPP-binding site; other site 1246995019720 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1246995019721 PYR/PP interface [polypeptide binding]; other site 1246995019722 dimer interface [polypeptide binding]; other site 1246995019723 TPP binding site [chemical binding]; other site 1246995019724 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1246995019725 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1246995019726 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1246995019727 TRAM domain; Region: TRAM; pfam01938 1246995019728 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1246995019729 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1246995019730 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1246995019731 TrkA-N domain; Region: TrkA_N; pfam02254 1246995019732 TrkA-C domain; Region: TrkA_C; pfam02080 1246995019733 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1246995019734 TrkA-N domain; Region: TrkA_N; pfam02254 1246995019735 TrkA-C domain; Region: TrkA_C; pfam02080 1246995019736 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 1246995019737 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1246995019738 ssDNA binding site; other site 1246995019739 generic binding surface II; other site 1246995019740 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 1246995019741 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1246995019742 trimer interface [polypeptide binding]; other site 1246995019743 active site 1246995019744 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 1246995019745 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 1246995019746 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1246995019747 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1246995019748 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1246995019749 active site 1246995019750 dimerization interface [polypeptide binding]; other site 1246995019751 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1246995019752 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1246995019753 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995019754 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1246995019755 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1246995019756 DNA binding residues [nucleotide binding] 1246995019757 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1246995019758 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1246995019759 ATP binding site [chemical binding]; other site 1246995019760 putative Mg++ binding site [ion binding]; other site 1246995019761 Predicted membrane protein [Function unknown]; Region: COG2860 1246995019762 UPF0126 domain; Region: UPF0126; pfam03458 1246995019763 UPF0126 domain; Region: UPF0126; pfam03458 1246995019764 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 1246995019765 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 1246995019766 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1246995019767 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1246995019768 substrate binding site [chemical binding]; other site 1246995019769 ATP binding site [chemical binding]; other site 1246995019770 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 1246995019771 CHASE domain; Region: CHASE; cl01369 1246995019772 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1246995019773 metal binding site [ion binding]; metal-binding site 1246995019774 active site 1246995019775 I-site; other site 1246995019776 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1246995019777 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1246995019778 minor groove reading motif; other site 1246995019779 helix-hairpin-helix signature motif; other site 1246995019780 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1246995019781 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1246995019782 DNA-binding site [nucleotide binding]; DNA binding site 1246995019783 UTRA domain; Region: UTRA; pfam07702 1246995019784 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1246995019785 intersubunit interface [polypeptide binding]; other site 1246995019786 active site 1246995019787 catalytic residue [active] 1246995019788 CHASE domain; Region: CHASE; cl01369 1246995019789 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1246995019790 metal binding site [ion binding]; metal-binding site 1246995019791 active site 1246995019792 I-site; other site 1246995019793 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1246995019794 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1246995019795 active site 1246995019796 ATP binding site [chemical binding]; other site 1246995019797 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1246995019798 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1246995019799 putative active site [active] 1246995019800 dimerization interface [polypeptide binding]; other site 1246995019801 putative tRNAtyr binding site [nucleotide binding]; other site 1246995019802 SpoOM protein; Region: Spo0M; pfam07070 1246995019803 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 1246995019804 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1246995019805 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1246995019806 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995019807 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1246995019808 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1246995019809 DNA binding residues [nucleotide binding] 1246995019810 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1246995019811 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1246995019812 Coenzyme A binding pocket [chemical binding]; other site 1246995019813 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 1246995019814 CoA binding domain; Region: CoA_binding_2; pfam13380 1246995019815 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1246995019816 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 1246995019817 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1246995019818 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 1246995019819 active site 1246995019820 Zn binding site [ion binding]; other site 1246995019821 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1246995019822 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 1246995019823 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1246995019824 FeoA domain; Region: FeoA; pfam04023 1246995019825 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1246995019826 Helix-turn-helix domain; Region: HTH_18; pfam12833 1246995019827 TIGR03086 family protein; Region: TIGR03086 1246995019828 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1246995019829 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 1246995019830 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 1246995019831 active site 1246995019832 catalytic triad [active] 1246995019833 oxyanion hole [active] 1246995019834 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048 1246995019835 RNAase interaction site [polypeptide binding]; other site 1246995019836 vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556 1246995019837 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 1246995019838 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 1246995019839 active site 1246995019840 dimer interface [polypeptide binding]; other site 1246995019841 effector binding site; other site 1246995019842 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1246995019843 TSCPD domain; Region: TSCPD; pfam12637 1246995019844 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1246995019845 ATP cone domain; Region: ATP-cone; pfam03477 1246995019846 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1246995019847 LexA repressor; Validated; Region: PRK00215 1246995019848 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1246995019849 putative switch regulator; other site 1246995019850 non-specific DNA interactions [nucleotide binding]; other site 1246995019851 DNA binding site [nucleotide binding] 1246995019852 sequence specific DNA binding site [nucleotide binding]; other site 1246995019853 putative cAMP binding site [chemical binding]; other site 1246995019854 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1246995019855 Catalytic site [active] 1246995019856 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 1246995019857 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1246995019858 DDE superfamily endonuclease; Region: DDE_4; pfam13359 1246995019859 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1246995019860 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1246995019861 HflX GTPase family; Region: HflX; cd01878 1246995019862 G1 box; other site 1246995019863 GTP/Mg2+ binding site [chemical binding]; other site 1246995019864 Switch I region; other site 1246995019865 G2 box; other site 1246995019866 G3 box; other site 1246995019867 Switch II region; other site 1246995019868 G4 box; other site 1246995019869 G5 box; other site 1246995019870 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1246995019871 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1246995019872 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1246995019873 Malic enzyme, NAD binding domain; Region: Malic_M; smart00919 1246995019874 NAD(P) binding pocket [chemical binding]; other site 1246995019875 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1246995019876 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1246995019877 active site 1246995019878 catalytic site [active] 1246995019879 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1246995019880 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1246995019881 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1246995019882 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1246995019883 IPP transferase; Region: IPPT; pfam01715 1246995019884 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1246995019885 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1246995019886 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1246995019887 hypothetical protein; Provisional; Region: PRK06815 1246995019888 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1246995019889 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1246995019890 catalytic residue [active] 1246995019891 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1246995019892 apolar tunnel; other site 1246995019893 heme binding site [chemical binding]; other site 1246995019894 dimerization interface [polypeptide binding]; other site 1246995019895 Predicted transcriptional regulators [Transcription]; Region: COG1733 1246995019896 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1246995019897 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1246995019898 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1246995019899 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1246995019900 dimerization interface [polypeptide binding]; other site 1246995019901 Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324 1246995019902 short chain dehydrogenase; Provisional; Region: PRK12828 1246995019903 NADP binding site [chemical binding]; other site 1246995019904 substrate binding site [chemical binding]; other site 1246995019905 active site 1246995019906 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1246995019907 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1246995019908 metal binding site [ion binding]; metal-binding site 1246995019909 active site 1246995019910 I-site; other site 1246995019911 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 1246995019912 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1246995019913 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1246995019914 FeS/SAM binding site; other site 1246995019915 TRAM domain; Region: TRAM; cl01282 1246995019916 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1246995019917 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1246995019918 Walker A/P-loop; other site 1246995019919 ATP binding site [chemical binding]; other site 1246995019920 Q-loop/lid; other site 1246995019921 ABC transporter signature motif; other site 1246995019922 Walker B; other site 1246995019923 D-loop; other site 1246995019924 H-loop/switch region; other site 1246995019925 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1246995019926 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1246995019927 substrate binding pocket [chemical binding]; other site 1246995019928 membrane-bound complex binding site; other site 1246995019929 hinge residues; other site 1246995019930 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995019931 dimer interface [polypeptide binding]; other site 1246995019932 conserved gate region; other site 1246995019933 putative PBP binding loops; other site 1246995019934 ABC-ATPase subunit interface; other site 1246995019935 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995019936 dimer interface [polypeptide binding]; other site 1246995019937 conserved gate region; other site 1246995019938 putative PBP binding loops; other site 1246995019939 ABC-ATPase subunit interface; other site 1246995019940 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 1246995019941 active site 1 [active] 1246995019942 dimer interface [polypeptide binding]; other site 1246995019943 hexamer interface [polypeptide binding]; other site 1246995019944 active site 2 [active] 1246995019945 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1246995019946 phosphodiesterase; Provisional; Region: PRK12704 1246995019947 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1246995019948 Zn2+ binding site [ion binding]; other site 1246995019949 Mg2+ binding site [ion binding]; other site 1246995019950 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 1246995019951 RecX family; Region: RecX; pfam02631 1246995019952 recombinase A; Provisional; Region: recA; PRK09354 1246995019953 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1246995019954 hexamer interface [polypeptide binding]; other site 1246995019955 Walker A motif; other site 1246995019956 ATP binding site [chemical binding]; other site 1246995019957 Walker B motif; other site 1246995019958 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 1246995019959 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1246995019960 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 1246995019961 Fe-S cluster binding site [ion binding]; other site 1246995019962 active site 1246995019963 ATP cone domain; Region: ATP-cone; pfam03477 1246995019964 ribonucleoside-diphosphate reductase, alpha subunit; Region: NrdE_NrdA; TIGR02506 1246995019965 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1246995019966 active site 1246995019967 dimer interface [polypeptide binding]; other site 1246995019968 catalytic residues [active] 1246995019969 effector binding site; other site 1246995019970 R2 peptide binding site; other site 1246995019971 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1246995019972 dimer interface [polypeptide binding]; other site 1246995019973 putative radical transfer pathway; other site 1246995019974 diiron center [ion binding]; other site 1246995019975 tyrosyl radical; other site 1246995019976 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1246995019977 transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481 1246995019978 DNA-binding site [nucleotide binding]; DNA binding site 1246995019979 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1246995019980 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1246995019981 homodimer interface [polypeptide binding]; other site 1246995019982 catalytic residue [active] 1246995019983 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 1246995019984 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1246995019985 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1246995019986 Predicted membrane protein [Function unknown]; Region: COG2259 1246995019987 leucine export protein LeuE; Provisional; Region: PRK10958 1246995019988 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 1246995019989 SpoOM protein; Region: Spo0M; pfam07070 1246995019990 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1246995019991 Domain of unknown function DUF21; Region: DUF21; pfam01595 1246995019992 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1246995019993 Domain of unknown function DUF21; Region: DUF21; pfam01595 1246995019994 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1246995019995 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1246995019996 Transporter associated domain; Region: CorC_HlyC; smart01091 1246995019997 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 1246995019998 Peptidase family M28; Region: Peptidase_M28; pfam04389 1246995019999 active site 1246995020000 metal binding site [ion binding]; metal-binding site 1246995020001 Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members...; Region: MAM; cl02479 1246995020002 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1246995020003 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1246995020004 active site 1246995020005 ATP binding site [chemical binding]; other site 1246995020006 substrate binding site [chemical binding]; other site 1246995020007 activation loop (A-loop); other site 1246995020008 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 1246995020009 active site 1246995020010 putative catalytic site [active] 1246995020011 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 1246995020012 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 1246995020013 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1246995020014 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 1246995020015 ATP binding site [chemical binding]; other site 1246995020016 putative Mg++ binding site [ion binding]; other site 1246995020017 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1246995020018 nucleotide binding region [chemical binding]; other site 1246995020019 ATP-binding site [chemical binding]; other site 1246995020020 DEAD/H associated; Region: DEAD_assoc; pfam08494 1246995020021 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1246995020022 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 1246995020023 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1246995020024 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 1246995020025 Hemerythrin-like domain; Region: Hr-like; cd12108 1246995020026 Fe binding site [ion binding]; other site 1246995020027 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1246995020028 DNA binding site [nucleotide binding] 1246995020029 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1246995020030 Predicted ATPase [General function prediction only]; Region: COG3903 1246995020031 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1246995020032 binding surface 1246995020033 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1246995020034 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 1246995020035 putative DNA binding site [nucleotide binding]; other site 1246995020036 catalytic residue [active] 1246995020037 putative H2TH interface [polypeptide binding]; other site 1246995020038 putative catalytic residues [active] 1246995020039 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1246995020040 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1246995020041 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1246995020042 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1246995020043 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1246995020044 non-specific DNA binding site [nucleotide binding]; other site 1246995020045 salt bridge; other site 1246995020046 sequence-specific DNA binding site [nucleotide binding]; other site 1246995020047 Competence-damaged protein; Region: CinA; pfam02464 1246995020048 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1246995020049 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 1246995020050 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1246995020051 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1246995020052 FeS/SAM binding site; other site 1246995020053 Predicted integral membrane protein [Function unknown]; Region: COG5542 1246995020054 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1246995020055 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1246995020056 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1246995020057 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1246995020058 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1246995020059 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 1246995020060 Alpha-lytic protease prodomain; Region: Pro_Al_protease; pfam02983 1246995020061 Trypsin; Region: Trypsin; pfam00089 1246995020062 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1246995020063 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1246995020064 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1246995020065 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1246995020066 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1246995020067 dimer interface [polypeptide binding]; other site 1246995020068 active site 1246995020069 catalytic residue [active] 1246995020070 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 1246995020071 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 1246995020072 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1246995020073 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1246995020074 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1246995020075 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1246995020076 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1246995020077 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995020078 dimer interface [polypeptide binding]; other site 1246995020079 conserved gate region; other site 1246995020080 ABC-ATPase subunit interface; other site 1246995020081 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1246995020082 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995020083 putative PBP binding loops; other site 1246995020084 dimer interface [polypeptide binding]; other site 1246995020085 ABC-ATPase subunit interface; other site 1246995020086 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1246995020087 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1246995020088 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1246995020089 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1246995020090 DNA binding site [nucleotide binding] 1246995020091 domain linker motif; other site 1246995020092 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1246995020093 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 1246995020094 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 1246995020095 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1246995020096 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1246995020097 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1246995020098 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 1246995020099 active site 1246995020100 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1246995020101 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1246995020102 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1246995020103 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 1246995020104 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1246995020105 RNase E interface [polypeptide binding]; other site 1246995020106 trimer interface [polypeptide binding]; other site 1246995020107 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1246995020108 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1246995020109 RNase E interface [polypeptide binding]; other site 1246995020110 trimer interface [polypeptide binding]; other site 1246995020111 active site 1246995020112 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1246995020113 putative nucleic acid binding region [nucleotide binding]; other site 1246995020114 G-X-X-G motif; other site 1246995020115 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1246995020116 RNA binding site [nucleotide binding]; other site 1246995020117 domain interface; other site 1246995020118 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1246995020119 16S/18S rRNA binding site [nucleotide binding]; other site 1246995020120 S13e-L30e interaction site [polypeptide binding]; other site 1246995020121 25S rRNA binding site [nucleotide binding]; other site 1246995020122 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1246995020123 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1246995020124 active site 1246995020125 Riboflavin kinase; Region: Flavokinase; pfam01687 1246995020126 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1246995020127 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1246995020128 dimer interface [polypeptide binding]; other site 1246995020129 phosphorylation site [posttranslational modification] 1246995020130 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995020131 ATP binding site [chemical binding]; other site 1246995020132 Mg2+ binding site [ion binding]; other site 1246995020133 G-X-G motif; other site 1246995020134 Response regulator receiver domain; Region: Response_reg; pfam00072 1246995020135 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995020136 active site 1246995020137 phosphorylation site [posttranslational modification] 1246995020138 intermolecular recognition site; other site 1246995020139 dimerization interface [polypeptide binding]; other site 1246995020140 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995020141 active site 1246995020142 phosphorylation site [posttranslational modification] 1246995020143 intermolecular recognition site; other site 1246995020144 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1246995020145 dimerization interface [polypeptide binding]; other site 1246995020146 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 1246995020147 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1246995020148 RNA binding site [nucleotide binding]; other site 1246995020149 active site 1246995020150 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 1246995020151 MarR family; Region: MarR_2; cl17246 1246995020152 MarR family; Region: MarR_2; pfam12802 1246995020153 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1246995020154 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1246995020155 putative efflux protein, MATE family; Region: matE; TIGR00797 1246995020156 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1246995020157 DHH family; Region: DHH; pfam01368 1246995020158 DHHA1 domain; Region: DHHA1; pfam02272 1246995020159 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1246995020160 Protein of unknown function (DUF503); Region: DUF503; pfam04456 1246995020161 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1246995020162 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1246995020163 translation initiation factor IF-2; Region: IF-2; TIGR00487 1246995020164 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1246995020165 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1246995020166 G1 box; other site 1246995020167 putative GEF interaction site [polypeptide binding]; other site 1246995020168 GTP/Mg2+ binding site [chemical binding]; other site 1246995020169 Switch I region; other site 1246995020170 G2 box; other site 1246995020171 G3 box; other site 1246995020172 Switch II region; other site 1246995020173 G4 box; other site 1246995020174 G5 box; other site 1246995020175 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1246995020176 Translation-initiation factor 2; Region: IF-2; pfam11987 1246995020177 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1246995020178 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 1246995020179 putative RNA binding cleft [nucleotide binding]; other site 1246995020180 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1246995020181 NusA N-terminal domain; Region: NusA_N; pfam08529 1246995020182 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1246995020183 RNA binding site [nucleotide binding]; other site 1246995020184 homodimer interface [polypeptide binding]; other site 1246995020185 NusA-like KH domain; Region: KH_5; pfam13184 1246995020186 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1246995020187 G-X-X-G motif; other site 1246995020188 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1246995020189 Sm and related proteins; Region: Sm_like; cl00259 1246995020190 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1246995020191 putative oligomer interface [polypeptide binding]; other site 1246995020192 putative RNA binding site [nucleotide binding]; other site 1246995020193 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1246995020194 dinuclear metal binding motif [ion binding]; other site 1246995020195 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 1246995020196 metal binding triad [ion binding]; metal-binding site 1246995020197 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 1246995020198 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1246995020199 active site 1246995020200 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1246995020201 anti sigma factor interaction site; other site 1246995020202 regulatory phosphorylation site [posttranslational modification]; other site 1246995020203 GAF domain; Region: GAF_3; pfam13492 1246995020204 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1246995020205 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1246995020206 dimer interface [polypeptide binding]; other site 1246995020207 phosphorylation site [posttranslational modification] 1246995020208 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995020209 ATP binding site [chemical binding]; other site 1246995020210 Mg2+ binding site [ion binding]; other site 1246995020211 G-X-G motif; other site 1246995020212 Response regulator receiver domain; Region: Response_reg; pfam00072 1246995020213 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995020214 active site 1246995020215 phosphorylation site [posttranslational modification] 1246995020216 intermolecular recognition site; other site 1246995020217 dimerization interface [polypeptide binding]; other site 1246995020218 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1246995020219 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1246995020220 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1246995020221 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1246995020222 ATP binding site [chemical binding]; other site 1246995020223 Mg2+ binding site [ion binding]; other site 1246995020224 G-X-G motif; other site 1246995020225 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 1246995020226 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 1246995020227 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1246995020228 catalytic triad [active] 1246995020229 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 1246995020230 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1246995020231 catalytic triad [active] 1246995020232 short chain dehydrogenase; Provisional; Region: PRK06057 1246995020233 classical (c) SDRs; Region: SDR_c; cd05233 1246995020234 NAD(P) binding site [chemical binding]; other site 1246995020235 active site 1246995020236 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1246995020237 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1246995020238 NAD(P) binding site [chemical binding]; other site 1246995020239 catalytic residues [active] 1246995020240 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1246995020241 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1246995020242 amino acid permease (GABA permease); Region: 2A0304; TIGR00907 1246995020243 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1246995020244 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1246995020245 DNA binding residues [nucleotide binding] 1246995020246 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995020247 NAD(P) binding site [chemical binding]; other site 1246995020248 active site 1246995020249 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 1246995020250 dimerization interface [polypeptide binding]; other site 1246995020251 putative DNA binding site [nucleotide binding]; other site 1246995020252 putative Zn2+ binding site [ion binding]; other site 1246995020253 Beta-lactamase; Region: Beta-lactamase; pfam00144 1246995020254 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1246995020255 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1246995020256 Histidine kinase; Region: HisKA_3; pfam07730 1246995020257 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995020258 ATP binding site [chemical binding]; other site 1246995020259 Mg2+ binding site [ion binding]; other site 1246995020260 G-X-G motif; other site 1246995020261 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995020262 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995020263 active site 1246995020264 phosphorylation site [posttranslational modification] 1246995020265 intermolecular recognition site; other site 1246995020266 dimerization interface [polypeptide binding]; other site 1246995020267 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995020268 DNA binding residues [nucleotide binding] 1246995020269 dimerization interface [polypeptide binding]; other site 1246995020270 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 1246995020271 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995020272 Walker A/P-loop; other site 1246995020273 ATP binding site [chemical binding]; other site 1246995020274 Q-loop/lid; other site 1246995020275 ABC transporter signature motif; other site 1246995020276 Walker B; other site 1246995020277 D-loop; other site 1246995020278 H-loop/switch region; other site 1246995020279 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1246995020280 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1246995020281 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995020282 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995020283 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1246995020284 Predicted membrane protein [Function unknown]; Region: COG1511 1246995020285 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1246995020286 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 1246995020287 Walker A/P-loop; other site 1246995020288 ATP binding site [chemical binding]; other site 1246995020289 Q-loop/lid; other site 1246995020290 ABC transporter signature motif; other site 1246995020291 Walker B; other site 1246995020292 D-loop; other site 1246995020293 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 1246995020294 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1246995020295 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 1246995020296 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1246995020297 Predicted transcriptional regulators [Transcription]; Region: COG1695 1246995020298 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1246995020299 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1246995020300 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1246995020301 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1246995020302 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 1246995020303 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1246995020304 active site 1246995020305 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1246995020306 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1246995020307 putative substrate binding region [chemical binding]; other site 1246995020308 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1246995020309 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1246995020310 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1246995020311 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1246995020312 YcxB-like protein; Region: YcxB; pfam14317 1246995020313 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1246995020314 MMPL family; Region: MMPL; pfam03176 1246995020315 Protein export membrane protein; Region: SecD_SecF; cl14618 1246995020316 MMPL family; Region: MMPL; pfam03176 1246995020317 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995020318 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995020319 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1246995020320 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1246995020321 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1246995020322 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1246995020323 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1246995020324 iron-sulfur cluster [ion binding]; other site 1246995020325 [2Fe-2S] cluster binding site [ion binding]; other site 1246995020326 Protein of unknown function (DUF2631); Region: DUF2631; pfam10939 1246995020327 DivIVA domain; Region: DivI1A_domain; TIGR03544 1246995020328 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 1246995020329 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1246995020330 FeS/SAM binding site; other site 1246995020331 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1246995020332 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1246995020333 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1246995020334 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1246995020335 hinge region; other site 1246995020336 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1246995020337 putative nucleotide binding site [chemical binding]; other site 1246995020338 uridine monophosphate binding site [chemical binding]; other site 1246995020339 homohexameric interface [polypeptide binding]; other site 1246995020340 elongation factor Ts; Provisional; Region: tsf; PRK09377 1246995020341 UBA/TS-N domain; Region: UBA; pfam00627 1246995020342 Elongation factor TS; Region: EF_TS; pfam00889 1246995020343 Elongation factor TS; Region: EF_TS; pfam00889 1246995020344 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1246995020345 rRNA interaction site [nucleotide binding]; other site 1246995020346 S8 interaction site; other site 1246995020347 putative laminin-1 binding site; other site 1246995020348 hypothetical protein; Reviewed; Region: PRK12497 1246995020349 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1246995020350 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1246995020351 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1246995020352 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1246995020353 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1246995020354 DNA protecting protein DprA; Region: dprA; TIGR00732 1246995020355 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1246995020356 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1246995020357 DNA-binding site [nucleotide binding]; DNA binding site 1246995020358 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1246995020359 DDE superfamily endonuclease; Region: DDE_4; pfam13359 1246995020360 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1246995020361 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1246995020362 active site 1246995020363 DNA binding site [nucleotide binding] 1246995020364 Int/Topo IB signature motif; other site 1246995020365 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1246995020366 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1246995020367 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1246995020368 catalytic residue [active] 1246995020369 Peptidase family M23; Region: Peptidase_M23; pfam01551 1246995020370 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 1246995020371 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1246995020372 RNA/DNA hybrid binding site [nucleotide binding]; other site 1246995020373 active site 1246995020374 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685 1246995020375 nudix motif; other site 1246995020376 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1246995020377 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1246995020378 Catalytic site [active] 1246995020379 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1246995020380 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1246995020381 Catalytic site [active] 1246995020382 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1246995020383 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1246995020384 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1246995020385 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1246995020386 RimM N-terminal domain; Region: RimM; pfam01782 1246995020387 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 1246995020388 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1246995020389 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 1246995020390 Protein of unknown function (DUF402); Region: DUF402; pfam04167 1246995020391 prolyl-tRNA synthetase; Provisional; Region: PRK08661 1246995020392 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 1246995020393 dimer interface [polypeptide binding]; other site 1246995020394 motif 1; other site 1246995020395 active site 1246995020396 motif 2; other site 1246995020397 motif 3; other site 1246995020398 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 1246995020399 anticodon binding site; other site 1246995020400 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1246995020401 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1246995020402 PQQ-like domain; Region: PQQ_2; pfam13360 1246995020403 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1246995020404 active site 1246995020405 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1246995020406 putative active site [active] 1246995020407 signal recognition particle protein; Provisional; Region: PRK10867 1246995020408 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1246995020409 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1246995020410 P loop; other site 1246995020411 GTP binding site [chemical binding]; other site 1246995020412 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1246995020413 Protein of unknown function (DUF3184); Region: DUF3184; pfam11380 1246995020414 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 1246995020415 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995020416 NAD(P) binding site [chemical binding]; other site 1246995020417 active site 1246995020418 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1246995020419 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1246995020420 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1246995020421 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1246995020422 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1246995020423 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1246995020424 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1246995020425 active site 1246995020426 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1246995020427 Protein of unknown function (DUF817); Region: DUF817; pfam05675 1246995020428 PII uridylyl-transferase; Provisional; Region: PRK03381 1246995020429 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1246995020430 metal binding triad; other site 1246995020431 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1246995020432 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 1246995020433 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1246995020434 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1246995020435 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1246995020436 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1246995020437 Phosphotransferase enzyme family; Region: APH; pfam01636 1246995020438 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1246995020439 active site 1246995020440 ATP binding site [chemical binding]; other site 1246995020441 substrate binding site [chemical binding]; other site 1246995020442 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 1246995020443 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1246995020444 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1246995020445 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1246995020446 putative active site [active] 1246995020447 putative metal binding site [ion binding]; other site 1246995020448 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1246995020449 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1246995020450 DinB superfamily; Region: DinB_2; pfam12867 1246995020451 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1246995020452 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995020453 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1246995020454 DNA binding residues [nucleotide binding] 1246995020455 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 1246995020456 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1246995020457 motif II; other site 1246995020458 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1246995020459 AAA domain; Region: AAA_23; pfam13476 1246995020460 Walker A/P-loop; other site 1246995020461 ATP binding site [chemical binding]; other site 1246995020462 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1246995020463 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1246995020464 ABC transporter signature motif; other site 1246995020465 Walker B; other site 1246995020466 D-loop; other site 1246995020467 H-loop/switch region; other site 1246995020468 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1246995020469 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1246995020470 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1246995020471 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1246995020472 Spherulation-specific family 4; Region: Spherulin4; pfam12138 1246995020473 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1246995020474 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1246995020475 DNA binding site [nucleotide binding] 1246995020476 catalytic residue [active] 1246995020477 H2TH interface [polypeptide binding]; other site 1246995020478 putative catalytic residues [active] 1246995020479 turnover-facilitating residue; other site 1246995020480 intercalation triad [nucleotide binding]; other site 1246995020481 8OG recognition residue [nucleotide binding]; other site 1246995020482 putative reading head residues; other site 1246995020483 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1246995020484 Mannosyltransferase (PIG-V)); Region: Mannosyl_trans2; pfam04188 1246995020485 ribonuclease III; Reviewed; Region: rnc; PRK00102 1246995020486 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1246995020487 dimerization interface [polypeptide binding]; other site 1246995020488 active site 1246995020489 metal binding site [ion binding]; metal-binding site 1246995020490 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1246995020491 dsRNA binding site [nucleotide binding]; other site 1246995020492 Fatty acid synthesis protein; Region: FA_synthesis; cl17261 1246995020493 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 1246995020494 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 1246995020495 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1246995020496 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1246995020497 active site 1246995020498 (T/H)XGH motif; other site 1246995020499 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 1246995020500 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1246995020501 S-adenosylmethionine binding site [chemical binding]; other site 1246995020502 Protein of unknown function (DUF952); Region: DUF952; pfam06108 1246995020503 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1246995020504 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1246995020505 generic binding surface II; other site 1246995020506 ssDNA binding site; other site 1246995020507 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1246995020508 ATP binding site [chemical binding]; other site 1246995020509 putative Mg++ binding site [ion binding]; other site 1246995020510 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1246995020511 nucleotide binding region [chemical binding]; other site 1246995020512 ATP-binding site [chemical binding]; other site 1246995020513 DAK2 domain; Region: Dak2; pfam02734 1246995020514 Dihydroxyacetone kinase family; Region: Dak1_2; pfam13684 1246995020515 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1246995020516 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1246995020517 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1246995020518 Coenzyme A binding pocket [chemical binding]; other site 1246995020519 thiamine monophosphate kinase; Provisional; Region: PRK05731 1246995020520 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1246995020521 ATP binding site [chemical binding]; other site 1246995020522 dimerization interface [polypeptide binding]; other site 1246995020523 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1246995020524 AsnC family; Region: AsnC_trans_reg; pfam01037 1246995020525 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 1246995020526 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1246995020527 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1246995020528 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1246995020529 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 1246995020530 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1246995020531 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1246995020532 Walker A/P-loop; other site 1246995020533 ATP binding site [chemical binding]; other site 1246995020534 Q-loop/lid; other site 1246995020535 ABC transporter signature motif; other site 1246995020536 Walker B; other site 1246995020537 D-loop; other site 1246995020538 H-loop/switch region; other site 1246995020539 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1246995020540 DNA-binding site [nucleotide binding]; DNA binding site 1246995020541 cystathionine gamma-lyase; Validated; Region: PRK07582 1246995020542 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1246995020543 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1246995020544 catalytic residue [active] 1246995020545 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1246995020546 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1246995020547 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1246995020548 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1246995020549 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1246995020550 putative acyl-acceptor binding pocket; other site 1246995020551 2-phospho-L-lactate guanylyltransferase; Region: F420_cofC; TIGR03552 1246995020552 polyphosphate kinase; Provisional; Region: PRK05443 1246995020553 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1246995020554 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1246995020555 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 1246995020556 putative domain interface [polypeptide binding]; other site 1246995020557 putative active site [active] 1246995020558 catalytic site [active] 1246995020559 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1246995020560 putative domain interface [polypeptide binding]; other site 1246995020561 putative active site [active] 1246995020562 catalytic site [active] 1246995020563 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1246995020564 active site 1246995020565 Ap6A binding site [chemical binding]; other site 1246995020566 nudix motif; other site 1246995020567 metal binding site [ion binding]; metal-binding site 1246995020568 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1246995020569 catalytic core [active] 1246995020570 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1246995020571 IHF dimer interface [polypeptide binding]; other site 1246995020572 IHF - DNA interface [nucleotide binding]; other site 1246995020573 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1246995020574 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1246995020575 substrate binding site [chemical binding]; other site 1246995020576 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1246995020577 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1246995020578 substrate binding site [chemical binding]; other site 1246995020579 ligand binding site [chemical binding]; other site 1246995020580 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1246995020581 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1246995020582 Bacterial transcriptional regulator; Region: IclR; pfam01614 1246995020583 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1246995020584 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1246995020585 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995020586 NAD(P) binding site [chemical binding]; other site 1246995020587 active site 1246995020588 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995020589 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995020590 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1246995020591 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 1246995020592 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1246995020593 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1246995020594 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1246995020595 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1246995020596 non-specific DNA binding site [nucleotide binding]; other site 1246995020597 salt bridge; other site 1246995020598 sequence-specific DNA binding site [nucleotide binding]; other site 1246995020599 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1246995020600 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1246995020601 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1246995020602 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1246995020603 Walker A/P-loop; other site 1246995020604 ATP binding site [chemical binding]; other site 1246995020605 Q-loop/lid; other site 1246995020606 ABC transporter signature motif; other site 1246995020607 Walker B; other site 1246995020608 D-loop; other site 1246995020609 H-loop/switch region; other site 1246995020610 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1246995020611 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1246995020612 RibD C-terminal domain; Region: RibD_C; cl17279 1246995020613 hypothetical protein; Provisional; Region: PRK09256 1246995020614 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 1246995020615 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1246995020616 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1246995020617 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 1246995020618 putative dimerization interface [polypeptide binding]; other site 1246995020619 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1246995020620 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1246995020621 dimerization interface [polypeptide binding]; other site 1246995020622 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1246995020623 dimer interface [polypeptide binding]; other site 1246995020624 phosphorylation site [posttranslational modification] 1246995020625 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995020626 ATP binding site [chemical binding]; other site 1246995020627 Mg2+ binding site [ion binding]; other site 1246995020628 G-X-G motif; other site 1246995020629 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1246995020630 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995020631 active site 1246995020632 phosphorylation site [posttranslational modification] 1246995020633 intermolecular recognition site; other site 1246995020634 dimerization interface [polypeptide binding]; other site 1246995020635 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1246995020636 DNA binding site [nucleotide binding] 1246995020637 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1246995020638 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 1246995020639 hypothetical protein; Provisional; Region: PRK13685 1246995020640 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1246995020641 metal ion-dependent adhesion site (MIDAS); other site 1246995020642 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1246995020643 Protein of unknown function DUF58; Region: DUF58; pfam01882 1246995020644 MoxR-like ATPases [General function prediction only]; Region: COG0714 1246995020645 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1246995020646 Walker A motif; other site 1246995020647 ATP binding site [chemical binding]; other site 1246995020648 Walker B motif; other site 1246995020649 arginine finger; other site 1246995020650 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1246995020651 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1246995020652 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1246995020653 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1246995020654 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1246995020655 Endonuclease/Exonuclease/phosphatase family; Region: Exo_endo_phos; pfam03372 1246995020656 putative metal binding site [ion binding]; other site 1246995020657 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1246995020658 putative catalytic site [active] 1246995020659 putative phosphate binding site [ion binding]; other site 1246995020660 putative metal binding site [ion binding]; other site 1246995020661 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995020662 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995020663 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1246995020664 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995020665 Walker A/P-loop; other site 1246995020666 ATP binding site [chemical binding]; other site 1246995020667 Q-loop/lid; other site 1246995020668 ABC transporter signature motif; other site 1246995020669 Walker B; other site 1246995020670 D-loop; other site 1246995020671 H-loop/switch region; other site 1246995020672 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1246995020673 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1246995020674 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 1246995020675 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 1246995020676 active site 1246995020677 catalytic residues [active] 1246995020678 metal binding site [ion binding]; metal-binding site 1246995020679 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1246995020680 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 1246995020681 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 1246995020682 active site 1246995020683 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 1246995020684 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1246995020685 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1246995020686 homodimer interface [polypeptide binding]; other site 1246995020687 substrate-cofactor binding pocket; other site 1246995020688 catalytic residue [active] 1246995020689 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 1246995020690 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 1246995020691 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1246995020692 ligand binding site [chemical binding]; other site 1246995020693 NAD binding site [chemical binding]; other site 1246995020694 dimerization interface [polypeptide binding]; other site 1246995020695 catalytic site [active] 1246995020696 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1246995020697 putative L-serine binding site [chemical binding]; other site 1246995020698 mannosyl-3-phosphoglycerate synthase; Provisional; Region: PRK14503; cl12225 1246995020699 Mannosyl-3-phosphoglycerate synthase (osmo_MPGsynth); Region: Osmo_MPGsynth; pfam09488 1246995020700 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1246995020701 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1246995020702 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1246995020703 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1246995020704 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1246995020705 putative valine binding site [chemical binding]; other site 1246995020706 dimer interface [polypeptide binding]; other site 1246995020707 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1246995020708 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 1246995020709 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1246995020710 PYR/PP interface [polypeptide binding]; other site 1246995020711 dimer interface [polypeptide binding]; other site 1246995020712 TPP binding site [chemical binding]; other site 1246995020713 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1246995020714 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1246995020715 TPP-binding site [chemical binding]; other site 1246995020716 dimer interface [polypeptide binding]; other site 1246995020717 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1246995020718 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1246995020719 metal binding site [ion binding]; metal-binding site 1246995020720 active site 1246995020721 I-site; other site 1246995020722 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1246995020723 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 1246995020724 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 1246995020725 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1246995020726 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1246995020727 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1246995020728 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995020729 dimer interface [polypeptide binding]; other site 1246995020730 conserved gate region; other site 1246995020731 putative PBP binding loops; other site 1246995020732 ABC-ATPase subunit interface; other site 1246995020733 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995020734 dimer interface [polypeptide binding]; other site 1246995020735 conserved gate region; other site 1246995020736 ABC-ATPase subunit interface; other site 1246995020737 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 1246995020738 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1246995020739 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1246995020740 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1246995020741 DNA binding site [nucleotide binding] 1246995020742 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1246995020743 ligand binding site [chemical binding]; other site 1246995020744 dimerization interface [polypeptide binding]; other site 1246995020745 PAS domain S-box; Region: sensory_box; TIGR00229 1246995020746 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1246995020747 putative active site [active] 1246995020748 heme pocket [chemical binding]; other site 1246995020749 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1246995020750 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1246995020751 metal binding site [ion binding]; metal-binding site 1246995020752 active site 1246995020753 I-site; other site 1246995020754 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1246995020755 Ubiquitin-like proteins; Region: UBQ; cl00155 1246995020756 charged pocket; other site 1246995020757 hydrophobic patch; other site 1246995020758 BNR repeat-like domain; Region: BNR_2; pfam13088 1246995020759 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1246995020760 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1246995020761 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_7; cd12166 1246995020762 putative ligand binding site [chemical binding]; other site 1246995020763 putative NAD binding site [chemical binding]; other site 1246995020764 catalytic site [active] 1246995020765 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1246995020766 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1246995020767 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1246995020768 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1246995020769 active site 1246995020770 metal binding site [ion binding]; metal-binding site 1246995020771 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1246995020772 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1246995020773 GatB domain; Region: GatB_Yqey; smart00845 1246995020774 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1246995020775 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1246995020776 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1246995020777 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1246995020778 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1246995020779 metal binding site [ion binding]; metal-binding site 1246995020780 active site 1246995020781 I-site; other site 1246995020782 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1246995020783 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1246995020784 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1246995020785 nucleotide binding pocket [chemical binding]; other site 1246995020786 K-X-D-G motif; other site 1246995020787 catalytic site [active] 1246995020788 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1246995020789 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1246995020790 PemK-like protein; Region: PemK; pfam02452 1246995020791 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1246995020792 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1246995020793 active site 1246995020794 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 1246995020795 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1246995020796 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1246995020797 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1246995020798 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1246995020799 catalytic residue [active] 1246995020800 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1246995020801 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1246995020802 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1246995020803 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1246995020804 Ligand binding site [chemical binding]; other site 1246995020805 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1246995020806 Domain of unknown function (DUF202); Region: DUF202; cl09954 1246995020807 hypothetical protein; Provisional; Region: PRK05858 1246995020808 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1246995020809 PYR/PP interface [polypeptide binding]; other site 1246995020810 dimer interface [polypeptide binding]; other site 1246995020811 TPP binding site [chemical binding]; other site 1246995020812 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1246995020813 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 1246995020814 TPP-binding site; other site 1246995020815 dimer interface [polypeptide binding]; other site 1246995020816 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 1246995020817 nucleotide binding site [chemical binding]; other site 1246995020818 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1246995020819 SBD interface [polypeptide binding]; other site 1246995020820 enoyl-CoA hydratase; Provisional; Region: PRK05862 1246995020821 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1246995020822 substrate binding site [chemical binding]; other site 1246995020823 oxyanion hole (OAH) forming residues; other site 1246995020824 trimer interface [polypeptide binding]; other site 1246995020825 Predicted membrane protein [Function unknown]; Region: COG4270 1246995020826 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1246995020827 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1246995020828 substrate binding site [chemical binding]; other site 1246995020829 dimer interface [polypeptide binding]; other site 1246995020830 ATP binding site [chemical binding]; other site 1246995020831 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1246995020832 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995020833 Walker A/P-loop; other site 1246995020834 ATP binding site [chemical binding]; other site 1246995020835 Q-loop/lid; other site 1246995020836 ABC transporter signature motif; other site 1246995020837 Walker B; other site 1246995020838 D-loop; other site 1246995020839 H-loop/switch region; other site 1246995020840 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1246995020841 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1246995020842 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1246995020843 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1246995020844 Protein of unknown function, DUF393; Region: DUF393; pfam04134 1246995020845 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995020846 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995020847 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1246995020848 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1246995020849 metal-binding site [ion binding] 1246995020850 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1246995020851 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1246995020852 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995020853 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1246995020854 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1246995020855 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1246995020856 catalytic site [active] 1246995020857 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 1246995020858 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1246995020859 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 1246995020860 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1246995020861 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1246995020862 Arginase-like amidino hydrolase family; Region: Arginase-like_1; cd09999 1246995020863 active site 1246995020864 Mn binding site [ion binding]; other site 1246995020865 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1246995020866 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 1246995020867 short chain dehydrogenase; Provisional; Region: PRK06197 1246995020868 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995020869 NAD(P) binding site [chemical binding]; other site 1246995020870 active site 1246995020871 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995020872 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995020873 DDE superfamily endonuclease; Region: DDE_5; pfam13546 1246995020874 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680 1246995020875 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1246995020876 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1246995020877 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1246995020878 active site 1246995020879 Zn binding site [ion binding]; other site 1246995020880 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 1246995020881 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 1246995020882 putative ligand binding site [chemical binding]; other site 1246995020883 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1246995020884 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1246995020885 metal binding site [ion binding]; metal-binding site 1246995020886 active site 1246995020887 I-site; other site 1246995020888 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1246995020889 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1246995020890 Predicted transcriptional regulators [Transcription]; Region: COG1695 1246995020891 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1246995020892 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 1246995020893 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 1246995020894 Walker A; other site 1246995020895 putative acyltransferase; Provisional; Region: PRK05790 1246995020896 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1246995020897 dimer interface [polypeptide binding]; other site 1246995020898 active site 1246995020899 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1246995020900 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 1246995020901 dimer interface [polypeptide binding]; other site 1246995020902 substrate binding site [chemical binding]; other site 1246995020903 metal binding site [ion binding]; metal-binding site 1246995020904 DivIVA domain; Region: DivI1A_domain; TIGR03544 1246995020905 Apolipoprotein A1/A4/E domain; Region: Apolipoprotein; pfam01442 1246995020906 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1246995020907 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1246995020908 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1246995020909 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1246995020910 Methylomonas sp. 4,4'-diapolycopene-dialdehyde dehydrogenase-like; Region: ALDH_DDALDH; cd07099 1246995020911 NAD(P) binding site [chemical binding]; other site 1246995020912 catalytic residues [active] 1246995020913 heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189 1246995020914 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995020915 Walker A/P-loop; other site 1246995020916 ATP binding site [chemical binding]; other site 1246995020917 Q-loop/lid; other site 1246995020918 ABC transporter signature motif; other site 1246995020919 Walker B; other site 1246995020920 D-loop; other site 1246995020921 H-loop/switch region; other site 1246995020922 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 1246995020923 hypothetical protein; Provisional; Region: PRK03298 1246995020924 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 1246995020925 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1246995020926 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1246995020927 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1246995020928 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1246995020929 Walker A/P-loop; other site 1246995020930 ATP binding site [chemical binding]; other site 1246995020931 Q-loop/lid; other site 1246995020932 ABC transporter signature motif; other site 1246995020933 Walker B; other site 1246995020934 D-loop; other site 1246995020935 H-loop/switch region; other site 1246995020936 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1246995020937 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1246995020938 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1246995020939 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 1246995020940 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1246995020941 Protein of unknown function (DUF1349); Region: DUF1349; cl01397 1246995020942 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1246995020943 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1246995020944 hinge; other site 1246995020945 active site 1246995020946 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 1246995020947 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 1246995020948 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1246995020949 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1246995020950 gamma subunit interface [polypeptide binding]; other site 1246995020951 epsilon subunit interface [polypeptide binding]; other site 1246995020952 LBP interface [polypeptide binding]; other site 1246995020953 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1246995020954 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1246995020955 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1246995020956 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1246995020957 alpha subunit interaction interface [polypeptide binding]; other site 1246995020958 Walker A motif; other site 1246995020959 ATP binding site [chemical binding]; other site 1246995020960 Walker B motif; other site 1246995020961 inhibitor binding site; inhibition site 1246995020962 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1246995020963 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1246995020964 core domain interface [polypeptide binding]; other site 1246995020965 delta subunit interface [polypeptide binding]; other site 1246995020966 epsilon subunit interface [polypeptide binding]; other site 1246995020967 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1246995020968 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1246995020969 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1246995020970 beta subunit interaction interface [polypeptide binding]; other site 1246995020971 Walker A motif; other site 1246995020972 ATP binding site [chemical binding]; other site 1246995020973 Walker B motif; other site 1246995020974 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1246995020975 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 1246995020976 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1246995020977 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1246995020978 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1246995020979 ATP synthase subunit C; Region: ATP-synt_C; cl00466 1246995020980 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1246995020981 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1246995020982 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754 1246995020983 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1246995020984 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1246995020985 dimer interface [polypeptide binding]; other site 1246995020986 active site 1246995020987 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1246995020988 folate binding site [chemical binding]; other site 1246995020989 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1246995020990 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 1246995020991 putative NAD(P) binding site [chemical binding]; other site 1246995020992 putative active site [active] 1246995020993 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 1246995020994 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1246995020995 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 1246995020996 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1246995020997 Low molecular weight phosphatase family; Region: LMWPc; cl00105 1246995020998 active site 1246995020999 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1246995021000 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1246995021001 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1246995021002 S-adenosylmethionine binding site [chemical binding]; other site 1246995021003 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1246995021004 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1246995021005 metal binding site [ion binding]; metal-binding site 1246995021006 active site 1246995021007 I-site; other site 1246995021008 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1246995021009 Trp docking motif [polypeptide binding]; other site 1246995021010 PQQ-like domain; Region: PQQ_2; pfam13360 1246995021011 active site 1246995021012 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1246995021013 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1246995021014 RF-1 domain; Region: RF-1; pfam00472 1246995021015 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1246995021016 RNA ligase; Region: RNA_lig_T4_1; cl09743 1246995021017 polynucleotide kinase; Provisional; Region: pseT; PHA02530 1246995021018 hypothetical protein; Provisional; Region: PRK06762 1246995021019 RNA ligase; Region: RNA_ligase; pfam09414 1246995021020 Nitric oxide synthase (NOS) produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N(omega)-hydroxy-L-arginine (NHA) as an...; Region: NOS_oxygenase; cd00575 1246995021021 active site 1246995021022 dimer interface [polypeptide binding]; other site 1246995021023 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1246995021024 transcription termination factor Rho; Provisional; Region: PRK12608 1246995021025 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1246995021026 RNA binding site [nucleotide binding]; other site 1246995021027 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1246995021028 Walker A motif; other site 1246995021029 ATP binding site [chemical binding]; other site 1246995021030 Walker B motif; other site 1246995021031 homoserine kinase; Provisional; Region: PRK01212 1246995021032 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1246995021033 H+ Antiporter protein; Region: 2A0121; TIGR00900 1246995021034 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1246995021035 Protein export membrane protein; Region: SecD_SecF; cl14618 1246995021036 Septum formation topological specificity factor MinE; Region: MinE; cl00538 1246995021037 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1246995021038 MarR family; Region: MarR; pfam01047 1246995021039 threonine synthase; Reviewed; Region: PRK06721 1246995021040 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1246995021041 homodimer interface [polypeptide binding]; other site 1246995021042 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1246995021043 catalytic residue [active] 1246995021044 homoserine dehydrogenase; Provisional; Region: PRK06349 1246995021045 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1246995021046 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1246995021047 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1246995021048 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1246995021049 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1246995021050 active site 1246995021051 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1246995021052 substrate binding site [chemical binding]; other site 1246995021053 catalytic residues [active] 1246995021054 dimer interface [polypeptide binding]; other site 1246995021055 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1246995021056 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1246995021057 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1246995021058 active site 1246995021059 HIGH motif; other site 1246995021060 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1246995021061 KMSK motif region; other site 1246995021062 tRNA binding surface [nucleotide binding]; other site 1246995021063 DALR anticodon binding domain; Region: DALR_1; smart00836 1246995021064 anticodon binding site; other site 1246995021065 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 1246995021066 Domain of unknown function (DUF305); Region: DUF305; pfam03713 1246995021067 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1246995021068 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1246995021069 NAD(P) binding site [chemical binding]; other site 1246995021070 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1246995021071 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1246995021072 substrate binding site [chemical binding]; other site 1246995021073 oxyanion hole (OAH) forming residues; other site 1246995021074 trimer interface [polypeptide binding]; other site 1246995021075 AAA domain; Region: AAA_17; pfam13207 1246995021076 AAA domain; Region: AAA_18; pfam13238 1246995021077 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1246995021078 sugar binding site [chemical binding]; other site 1246995021079 CARDB; Region: CARDB; pfam07705 1246995021080 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 1246995021081 putative metal binding site [ion binding]; other site 1246995021082 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1246995021083 Right handed beta helix region; Region: Beta_helix; pfam13229 1246995021084 short chain dehydrogenase; Provisional; Region: PRK08263 1246995021085 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1246995021086 NADP binding site [chemical binding]; other site 1246995021087 active site 1246995021088 steroid binding site; other site 1246995021089 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1246995021090 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1246995021091 acyl-activating enzyme (AAE) consensus motif; other site 1246995021092 acyl-activating enzyme (AAE) consensus motif; other site 1246995021093 AMP binding site [chemical binding]; other site 1246995021094 active site 1246995021095 CoA binding site [chemical binding]; other site 1246995021096 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 1246995021097 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1246995021098 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1246995021099 active sites [active] 1246995021100 tetramer interface [polypeptide binding]; other site 1246995021101 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1246995021102 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1246995021103 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015 1246995021104 active site 1246995021105 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 1246995021106 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 1246995021107 active site 1246995021108 substrate binding site [chemical binding]; other site 1246995021109 FMN binding site [chemical binding]; other site 1246995021110 putative catalytic residues [active] 1246995021111 Cytochrome P450; Region: p450; cl12078 1246995021112 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1246995021113 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1246995021114 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995021115 active site 1246995021116 phosphorylation site [posttranslational modification] 1246995021117 intermolecular recognition site; other site 1246995021118 dimerization interface [polypeptide binding]; other site 1246995021119 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1246995021120 DNA binding site [nucleotide binding] 1246995021121 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1246995021122 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1246995021123 dimer interface [polypeptide binding]; other site 1246995021124 phosphorylation site [posttranslational modification] 1246995021125 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995021126 ATP binding site [chemical binding]; other site 1246995021127 Mg2+ binding site [ion binding]; other site 1246995021128 G-X-G motif; other site 1246995021129 cobyrinic acid a,c-diamide synthase; Provisional; Region: PRK13896 1246995021130 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1246995021131 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1246995021132 active site 1246995021133 ATP binding site [chemical binding]; other site 1246995021134 substrate binding site [chemical binding]; other site 1246995021135 activation loop (A-loop); other site 1246995021136 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1246995021137 SnoaL-like domain; Region: SnoaL_2; pfam12680 1246995021138 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1246995021139 Beta-lactamase; Region: Beta-lactamase; pfam00144 1246995021140 Domain of unknown function (DUF3817); Region: DUF3817; cl14844 1246995021141 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1246995021142 active site 1246995021143 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 1246995021144 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1246995021145 Predicted transcriptional regulators [Transcription]; Region: COG1733 1246995021146 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1246995021147 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1246995021148 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1246995021149 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 1246995021150 VanZ like family; Region: VanZ; cl01971 1246995021151 short chain dehydrogenase; Provisional; Region: PRK06180 1246995021152 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1246995021153 NADP binding site [chemical binding]; other site 1246995021154 active site 1246995021155 steroid binding site; other site 1246995021156 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1246995021157 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1246995021158 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1246995021159 dimerization interface [polypeptide binding]; other site 1246995021160 substrate binding pocket [chemical binding]; other site 1246995021161 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1246995021162 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995021163 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1246995021164 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1246995021165 putative substrate translocation pore; other site 1246995021166 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1246995021167 hypothetical protein; Provisional; Region: PRK02237 1246995021168 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1246995021169 anti sigma factor interaction site; other site 1246995021170 regulatory phosphorylation site [posttranslational modification]; other site 1246995021171 Helix-turn-helix domain; Region: HTH_18; pfam12833 1246995021172 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1246995021173 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1246995021174 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995021175 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 1246995021176 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1246995021177 Moco binding site; other site 1246995021178 metal coordination site [ion binding]; other site 1246995021179 dimerization interface [polypeptide binding]; other site 1246995021180 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 1246995021181 Fasciclin domain; Region: Fasciclin; pfam02469 1246995021182 Putative zinc-finger; Region: zf-HC2; pfam13490 1246995021183 putative anti-sigmaE protein; Provisional; Region: PRK13920 1246995021184 Anti-sigma-K factor rskA; Region: RskA; pfam10099 1246995021185 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 1246995021186 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995021187 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1246995021188 DNA binding residues [nucleotide binding] 1246995021189 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 1246995021190 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995021191 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1246995021192 DNA binding residues [nucleotide binding] 1246995021193 Predicted integral membrane proteins containing uncharacterized repeats [Function unknown]; Region: COG5563 1246995021194 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1246995021195 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1246995021196 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 1246995021197 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995021198 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1246995021199 DNA binding residues [nucleotide binding] 1246995021200 Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503 1246995021201 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1246995021202 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995021203 NAD(P) binding site [chemical binding]; other site 1246995021204 active site 1246995021205 trehalose synthase; Region: treS_nterm; TIGR02456 1246995021206 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 1246995021207 active site 1246995021208 catalytic site [active] 1246995021209 Predicted transcriptional regulators [Transcription]; Region: COG1695 1246995021210 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1246995021211 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1246995021212 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1246995021213 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 1246995021214 aromatic chitin/cellulose binding site residues [chemical binding]; other site 1246995021215 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 1246995021216 active site 1246995021217 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 1246995021218 aromatic chitin/cellulose binding site residues [chemical binding]; other site 1246995021219 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 1246995021220 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 1246995021221 putative active site [active] 1246995021222 60Kd inner membrane protein; Region: 60KD_IMP; pfam02096 1246995021223 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1246995021224 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1246995021225 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1246995021226 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 1246995021227 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1246995021228 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1246995021229 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1246995021230 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1246995021231 NodB motif; other site 1246995021232 active site 1246995021233 catalytic site [active] 1246995021234 metal binding site [ion binding]; metal-binding site 1246995021235 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 1246995021236 putative H2TH interface [polypeptide binding]; other site 1246995021237 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1246995021238 putative DNA binding site [nucleotide binding]; other site 1246995021239 putative catalytic residues [active] 1246995021240 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1246995021241 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1246995021242 Clp protease; Region: CLP_protease; pfam00574 1246995021243 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1246995021244 oligomer interface [polypeptide binding]; other site 1246995021245 active site residues [active] 1246995021246 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 1246995021247 Amidinotransferase; Region: Amidinotransf; cl12043 1246995021248 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1246995021249 ornithine--oxo-acid transaminase; Reviewed; Region: rocD; PRK00854 1246995021250 inhibitor-cofactor binding pocket; inhibition site 1246995021251 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1246995021252 catalytic residue [active] 1246995021253 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 1246995021254 phosphopeptide binding site; other site 1246995021255 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 1246995021256 aromatic arch; other site 1246995021257 DCoH dimer interaction site [polypeptide binding]; other site 1246995021258 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1246995021259 DCoH tetramer interaction site [polypeptide binding]; other site 1246995021260 substrate binding site [chemical binding]; other site 1246995021261 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1246995021262 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 1246995021263 putative acyl-acceptor binding pocket; other site 1246995021264 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 1246995021265 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1246995021266 nucleophile elbow; other site 1246995021267 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 1246995021268 aromatic chitin/cellulose binding site residues [chemical binding]; other site 1246995021269 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 1246995021270 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 1246995021271 putative active site [active] 1246995021272 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 1246995021273 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1246995021274 Walker A/P-loop; other site 1246995021275 ATP binding site [chemical binding]; other site 1246995021276 Q-loop/lid; other site 1246995021277 ABC transporter signature motif; other site 1246995021278 Walker B; other site 1246995021279 D-loop; other site 1246995021280 H-loop/switch region; other site 1246995021281 Uncharacterized protein conserved in archaea (DUF2180); Region: DUF2180; cl02017 1246995021282 Peptidase family M50; Region: Peptidase_M50; pfam02163 1246995021283 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cd05709 1246995021284 active site 1246995021285 putative substrate binding region [chemical binding]; other site 1246995021286 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1246995021287 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1246995021288 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1246995021289 protein binding site [polypeptide binding]; other site 1246995021290 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1246995021291 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1246995021292 dimerization interface [polypeptide binding]; other site 1246995021293 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1246995021294 dimer interface [polypeptide binding]; other site 1246995021295 phosphorylation site [posttranslational modification] 1246995021296 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995021297 ATP binding site [chemical binding]; other site 1246995021298 Mg2+ binding site [ion binding]; other site 1246995021299 G-X-G motif; other site 1246995021300 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1246995021301 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995021302 active site 1246995021303 phosphorylation site [posttranslational modification] 1246995021304 intermolecular recognition site; other site 1246995021305 dimerization interface [polypeptide binding]; other site 1246995021306 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1246995021307 DNA binding site [nucleotide binding] 1246995021308 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1246995021309 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1246995021310 putative acyl-acceptor binding pocket; other site 1246995021311 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 1246995021312 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1246995021313 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 1246995021314 Walker A/P-loop; other site 1246995021315 ATP binding site [chemical binding]; other site 1246995021316 Q-loop/lid; other site 1246995021317 ABC transporter signature motif; other site 1246995021318 Walker B; other site 1246995021319 D-loop; other site 1246995021320 H-loop/switch region; other site 1246995021321 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1246995021322 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 1246995021323 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1246995021324 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1246995021325 TPP-binding site [chemical binding]; other site 1246995021326 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1246995021327 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995021328 Walker A/P-loop; other site 1246995021329 ATP binding site [chemical binding]; other site 1246995021330 Q-loop/lid; other site 1246995021331 ABC transporter signature motif; other site 1246995021332 Walker B; other site 1246995021333 D-loop; other site 1246995021334 H-loop/switch region; other site 1246995021335 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995021336 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1246995021337 Walker A/P-loop; other site 1246995021338 ATP binding site [chemical binding]; other site 1246995021339 Q-loop/lid; other site 1246995021340 ABC transporter signature motif; other site 1246995021341 Walker B; other site 1246995021342 D-loop; other site 1246995021343 H-loop/switch region; other site 1246995021344 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1246995021345 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995021346 Walker A/P-loop; other site 1246995021347 ATP binding site [chemical binding]; other site 1246995021348 Q-loop/lid; other site 1246995021349 ABC transporter signature motif; other site 1246995021350 Walker B; other site 1246995021351 D-loop; other site 1246995021352 H-loop/switch region; other site 1246995021353 BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857 1246995021354 DRTGG domain; Region: DRTGG; pfam07085 1246995021355 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1246995021356 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1246995021357 propionate/acetate kinase; Provisional; Region: PRK12379 1246995021358 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1246995021359 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1246995021360 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1246995021361 NAD(P) binding site [chemical binding]; other site 1246995021362 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1246995021363 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1246995021364 Malic enzyme, NAD binding domain; Region: Malic_M; smart00919 1246995021365 NAD(P) binding pocket [chemical binding]; other site 1246995021366 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 1246995021367 Catalytic site [active] 1246995021368 Nickel-containing superoxide dismutase; Region: Sod_Ni; pfam09055 1246995021369 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1246995021370 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1246995021371 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1246995021372 DNA-binding site [nucleotide binding]; DNA binding site 1246995021373 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1246995021374 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1246995021375 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1246995021376 Transcription factor WhiB; Region: Whib; pfam02467 1246995021377 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1246995021378 putative active site [active] 1246995021379 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 1246995021380 active site 1246995021381 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1246995021382 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1246995021383 Active Sites [active] 1246995021384 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 1246995021385 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 1246995021386 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1246995021387 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1246995021388 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1246995021389 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 1246995021390 PAS fold; Region: PAS_4; pfam08448 1246995021391 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1246995021392 Histidine kinase; Region: HisKA_2; pfam07568 1246995021393 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995021394 ATP binding site [chemical binding]; other site 1246995021395 Mg2+ binding site [ion binding]; other site 1246995021396 G-X-G motif; other site 1246995021397 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1246995021398 dimer interface [polypeptide binding]; other site 1246995021399 active site 1246995021400 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1246995021401 dimer interface [polypeptide binding]; other site 1246995021402 active site 1246995021403 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1246995021404 carboxyltransferase (CT) interaction site; other site 1246995021405 biotinylation site [posttranslational modification]; other site 1246995021406 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988 1246995021407 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 1246995021408 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995021409 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1246995021410 DNA binding residues [nucleotide binding] 1246995021411 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 1246995021412 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 1246995021413 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1246995021414 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1246995021415 hinge; other site 1246995021416 active site 1246995021417 ribosome small subunit-dependent GTPase A; Region: TIGR00157 1246995021418 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1246995021419 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1246995021420 GTP/Mg2+ binding site [chemical binding]; other site 1246995021421 G4 box; other site 1246995021422 G1 box; other site 1246995021423 Switch I region; other site 1246995021424 G2 box; other site 1246995021425 G3 box; other site 1246995021426 Switch II region; other site 1246995021427 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 1246995021428 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1246995021429 active site 1246995021430 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1246995021431 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1246995021432 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995021433 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995021434 active site 1246995021435 phosphorylation site [posttranslational modification] 1246995021436 intermolecular recognition site; other site 1246995021437 dimerization interface [polypeptide binding]; other site 1246995021438 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995021439 DNA binding residues [nucleotide binding] 1246995021440 dimerization interface [polypeptide binding]; other site 1246995021441 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1246995021442 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995021443 ATP binding site [chemical binding]; other site 1246995021444 G-X-G motif; other site 1246995021445 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1246995021446 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1246995021447 Mg2+ binding site [ion binding]; other site 1246995021448 G-X-G motif; other site 1246995021449 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 1246995021450 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 1246995021451 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 1246995021452 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 1246995021453 active site 1246995021454 catalytic residues [active] 1246995021455 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1246995021456 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1246995021457 putative sugar binding sites [chemical binding]; other site 1246995021458 Q-X-W motif; other site 1246995021459 Transglycosylase; Region: Transgly; pfam00912 1246995021460 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1246995021461 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1246995021462 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1246995021463 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1246995021464 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1246995021465 catalytic residue [active] 1246995021466 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 1246995021467 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 1246995021468 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 1246995021469 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 1246995021470 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 1246995021471 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1246995021472 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1246995021473 ATP binding site [chemical binding]; other site 1246995021474 Mg2+ binding site [ion binding]; other site 1246995021475 G-X-G motif; other site 1246995021476 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995021477 NAD(P) binding site [chemical binding]; other site 1246995021478 active site 1246995021479 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 1246995021480 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 1246995021481 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 1246995021482 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1246995021483 S-adenosylmethionine binding site [chemical binding]; other site 1246995021484 MMPL family; Region: MMPL; pfam03176 1246995021485 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1246995021486 Integral membrane protein TerC family; Region: TerC; cl10468 1246995021487 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 1246995021488 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1246995021489 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1246995021490 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1246995021491 Lamin Tail Domain; Region: LTD; pfam00932 1246995021492 Uncharacterized protein conserved in bacteria (DUF2199); Region: DUF2199; cl02048 1246995021493 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1246995021494 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995021495 NAD(P) binding site [chemical binding]; other site 1246995021496 active site 1246995021497 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 1246995021498 hypothetical protein; Validated; Region: PRK00068 1246995021499 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1246995021500 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1246995021501 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 1246995021502 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 1246995021503 Protein of unknown function DUF45; Region: DUF45; pfam01863 1246995021504 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 1246995021505 ATP binding site [chemical binding]; other site 1246995021506 substrate interface [chemical binding]; other site 1246995021507 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1246995021508 ABC1 family; Region: ABC1; cl17513 1246995021509 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1246995021510 active site 1246995021511 ATP binding site [chemical binding]; other site 1246995021512 Transcription factor WhiB; Region: Whib; pfam02467 1246995021513 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1246995021514 Part of AAA domain; Region: AAA_19; pfam13245 1246995021515 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1246995021516 Family description; Region: UvrD_C_2; pfam13538 1246995021517 HRDC domain; Region: HRDC; pfam00570 1246995021518 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1246995021519 catalytic residues [active] 1246995021520 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 1246995021521 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995021522 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995021523 active site 1246995021524 phosphorylation site [posttranslational modification] 1246995021525 intermolecular recognition site; other site 1246995021526 dimerization interface [polypeptide binding]; other site 1246995021527 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995021528 DNA binding residues [nucleotide binding] 1246995021529 dimerization interface [polypeptide binding]; other site 1246995021530 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1246995021531 Histidine kinase; Region: HisKA_3; pfam07730 1246995021532 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995021533 ATP binding site [chemical binding]; other site 1246995021534 Mg2+ binding site [ion binding]; other site 1246995021535 G-X-G motif; other site 1246995021536 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 1246995021537 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 1246995021538 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 1246995021539 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1246995021540 putative NADH binding site [chemical binding]; other site 1246995021541 putative active site [active] 1246995021542 nudix motif; other site 1246995021543 putative metal binding site [ion binding]; other site 1246995021544 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1246995021545 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1246995021546 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1246995021547 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1246995021548 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1246995021549 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1246995021550 Caspase domain; Region: Peptidase_C14; pfam00656 1246995021551 Uncharacterized ACR, COG1678; Region: DUF179; cl00731 1246995021552 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1246995021553 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1246995021554 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1246995021555 NodB motif; other site 1246995021556 active site 1246995021557 catalytic site [active] 1246995021558 metal binding site [ion binding]; metal-binding site 1246995021559 Rrf2 family protein; Region: rrf2_super; TIGR00738 1246995021560 Transcriptional regulator; Region: Rrf2; pfam02082 1246995021561 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1246995021562 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1246995021563 substrate binding pocket [chemical binding]; other site 1246995021564 membrane-bound complex binding site; other site 1246995021565 hinge residues; other site 1246995021566 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1246995021567 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1246995021568 Walker A/P-loop; other site 1246995021569 ATP binding site [chemical binding]; other site 1246995021570 Q-loop/lid; other site 1246995021571 ABC transporter signature motif; other site 1246995021572 Walker B; other site 1246995021573 D-loop; other site 1246995021574 H-loop/switch region; other site 1246995021575 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1246995021576 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995021577 dimer interface [polypeptide binding]; other site 1246995021578 conserved gate region; other site 1246995021579 putative PBP binding loops; other site 1246995021580 ABC-ATPase subunit interface; other site 1246995021581 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1246995021582 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1246995021583 putative acyl-acceptor binding pocket; other site 1246995021584 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1246995021585 DNA-binding site [nucleotide binding]; DNA binding site 1246995021586 RNA-binding motif; other site 1246995021587 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1246995021588 Part of AAA domain; Region: AAA_19; pfam13245 1246995021589 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1246995021590 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1246995021591 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1246995021592 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1246995021593 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1246995021594 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1246995021595 DNA binding site [nucleotide binding] 1246995021596 domain linker motif; other site 1246995021597 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1246995021598 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 1246995021599 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1246995021600 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1246995021601 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 1246995021602 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 1246995021603 metal binding site [ion binding]; metal-binding site 1246995021604 putative dimer interface [polypeptide binding]; other site 1246995021605 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 1246995021606 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; cl02325 1246995021607 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 1246995021608 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 1246995021609 putative trimer interface [polypeptide binding]; other site 1246995021610 putative CoA binding site [chemical binding]; other site 1246995021611 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 1246995021612 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1246995021613 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1246995021614 dimerization interface [polypeptide binding]; other site 1246995021615 Lysine efflux permease [General function prediction only]; Region: COG1279 1246995021616 chlorophyllase; Region: PLN00021 1246995021617 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1246995021618 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1246995021619 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1246995021620 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1246995021621 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1246995021622 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 1246995021623 DNA binding residues [nucleotide binding] 1246995021624 drug binding residues [chemical binding]; other site 1246995021625 dimer interface [polypeptide binding]; other site 1246995021626 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cl17512 1246995021627 beta-clamp/clamp loader binding surface; other site 1246995021628 beta-clamp/translesion DNA polymerase binding surface; other site 1246995021629 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1246995021630 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 1246995021631 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1246995021632 catalytic residue [active] 1246995021633 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1246995021634 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1246995021635 active site 1246995021636 catalytic tetrad [active] 1246995021637 RNA polymerase factor sigma-70; Validated; Region: PRK08241 1246995021638 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995021639 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1246995021640 DNA binding residues [nucleotide binding] 1246995021641 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1246995021642 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1246995021643 classical (c) SDRs; Region: SDR_c; cd05233 1246995021644 NAD(P) binding site [chemical binding]; other site 1246995021645 active site 1246995021646 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1246995021647 putative DNA binding site [nucleotide binding]; other site 1246995021648 putative Zn2+ binding site [ion binding]; other site 1246995021649 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1246995021650 putative hydrophobic ligand binding site [chemical binding]; other site 1246995021651 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1246995021652 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1246995021653 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 1246995021654 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1246995021655 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 1246995021656 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1246995021657 putative active site [active] 1246995021658 putative dimer interface [polypeptide binding]; other site 1246995021659 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 1246995021660 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 1246995021661 classical (c) SDRs; Region: SDR_c; cd05233 1246995021662 NAD(P) binding site [chemical binding]; other site 1246995021663 active site 1246995021664 RNA polymerase factor sigma-70; Validated; Region: PRK08241 1246995021665 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995021666 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1246995021667 DNA binding residues [nucleotide binding] 1246995021668 SnoaL-like domain; Region: SnoaL_2; pfam12680 1246995021669 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1246995021670 endonuclease III; Region: ENDO3c; smart00478 1246995021671 minor groove reading motif; other site 1246995021672 helix-hairpin-helix signature motif; other site 1246995021673 substrate binding pocket [chemical binding]; other site 1246995021674 active site 1246995021675 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 1246995021676 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1246995021677 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1246995021678 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1246995021679 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1246995021680 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1246995021681 catalytic triad [active] 1246995021682 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1246995021683 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1246995021684 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 1246995021685 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1246995021686 legume lectins; Region: lectin_L-type; cd01951 1246995021687 homotetramer interaction site [polypeptide binding]; other site 1246995021688 carbohydrate binding site [chemical binding]; other site 1246995021689 metal binding site [ion binding]; metal-binding site 1246995021690 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 1246995021691 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 1246995021692 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1246995021693 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1246995021694 active site 1246995021695 catalytic tetrad [active] 1246995021696 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 1246995021697 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 1246995021698 active site 1246995021699 catalytic residues [active] 1246995021700 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 1246995021701 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1246995021702 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1246995021703 homodimer interface [polypeptide binding]; other site 1246995021704 catalytic residue [active] 1246995021705 Ferredoxin [Energy production and conversion]; Region: COG1146 1246995021706 4Fe-4S binding domain; Region: Fer4; pfam00037 1246995021707 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1246995021708 Coenzyme A binding pocket [chemical binding]; other site 1246995021709 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1246995021710 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995021711 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1246995021712 NAD(P) binding site [chemical binding]; other site 1246995021713 active site 1246995021714 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1246995021715 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1246995021716 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1246995021717 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 1246995021718 VanW like protein; Region: VanW; pfam04294 1246995021719 N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445 1246995021720 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 1246995021721 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1246995021722 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1246995021723 putative active site [active] 1246995021724 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1246995021725 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1246995021726 metal binding site [ion binding]; metal-binding site 1246995021727 active site 1246995021728 I-site; other site 1246995021729 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1246995021730 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 1246995021731 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 1246995021732 L-aspartate oxidase; Provisional; Region: PRK06175 1246995021733 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1246995021734 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 1246995021735 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1246995021736 catalytic loop [active] 1246995021737 iron binding site [ion binding]; other site 1246995021738 Integrin alpha; Region: Integrin_alpha2; pfam08441 1246995021739 Protease prsW family; Region: PrsW-protease; pfam13367 1246995021740 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 1246995021741 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1246995021742 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1246995021743 Walker A/P-loop; other site 1246995021744 ATP binding site [chemical binding]; other site 1246995021745 Q-loop/lid; other site 1246995021746 ABC transporter signature motif; other site 1246995021747 Walker B; other site 1246995021748 D-loop; other site 1246995021749 H-loop/switch region; other site 1246995021750 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1246995021751 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1246995021752 Walker A/P-loop; other site 1246995021753 ATP binding site [chemical binding]; other site 1246995021754 Q-loop/lid; other site 1246995021755 ABC transporter signature motif; other site 1246995021756 Walker B; other site 1246995021757 D-loop; other site 1246995021758 H-loop/switch region; other site 1246995021759 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1246995021760 TM-ABC transporter signature motif; other site 1246995021761 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1246995021762 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1246995021763 TM-ABC transporter signature motif; other site 1246995021764 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1246995021765 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1246995021766 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1246995021767 classical (c) SDRs; Region: SDR_c; cd05233 1246995021768 NAD(P) binding site [chemical binding]; other site 1246995021769 active site 1246995021770 short chain dehydrogenase; Provisional; Region: PRK05650 1246995021771 classical (c) SDRs; Region: SDR_c; cd05233 1246995021772 NAD(P) binding site [chemical binding]; other site 1246995021773 active site 1246995021774 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1246995021775 putative active site [active] 1246995021776 putative substrate binding site [chemical binding]; other site 1246995021777 ATP binding site [chemical binding]; other site 1246995021778 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1246995021779 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1246995021780 active site 1246995021781 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995021782 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995021783 Helix-turn-helix domain; Region: HTH_17; cl17695 1246995021784 Predicted transcriptional regulators [Transcription]; Region: COG1378 1246995021785 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 1246995021786 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995021787 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995021788 active site 1246995021789 phosphorylation site [posttranslational modification] 1246995021790 intermolecular recognition site; other site 1246995021791 dimerization interface [polypeptide binding]; other site 1246995021792 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995021793 DNA binding residues [nucleotide binding] 1246995021794 dimerization interface [polypeptide binding]; other site 1246995021795 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1246995021796 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1246995021797 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995021798 NAD(P) binding site [chemical binding]; other site 1246995021799 active site 1246995021800 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 1246995021801 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1246995021802 acyl-activating enzyme (AAE) consensus motif; other site 1246995021803 active site 1246995021804 AMP binding site [chemical binding]; other site 1246995021805 CoA binding site [chemical binding]; other site 1246995021806 Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439 1246995021807 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1246995021808 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1246995021809 Ligand binding site; other site 1246995021810 Putative Catalytic site; other site 1246995021811 DXD motif; other site 1246995021812 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 1246995021813 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 1246995021814 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1246995021815 NAD binding site [chemical binding]; other site 1246995021816 catalytic Zn binding site [ion binding]; other site 1246995021817 substrate binding site [chemical binding]; other site 1246995021818 structural Zn binding site [ion binding]; other site 1246995021819 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 1246995021820 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1246995021821 NAD binding site [chemical binding]; other site 1246995021822 catalytic residues [active] 1246995021823 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1246995021824 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995021825 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1246995021826 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1246995021827 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1246995021828 active site 1246995021829 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 1246995021830 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1246995021831 acyl-activating enzyme (AAE) consensus motif; other site 1246995021832 putative AMP binding site [chemical binding]; other site 1246995021833 putative active site [active] 1246995021834 putative CoA binding site [chemical binding]; other site 1246995021835 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1246995021836 active site 1246995021837 8-oxo-dGMP binding site [chemical binding]; other site 1246995021838 nudix motif; other site 1246995021839 metal binding site [ion binding]; metal-binding site 1246995021840 Pleckstrin homology-like domain; Region: PH-like; cl17171 1246995021841 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1246995021842 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1246995021843 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1246995021844 FOG: PKD repeat [General function prediction only]; Region: COG3291 1246995021845 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 1246995021846 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 1246995021847 metal binding site [ion binding]; metal-binding site 1246995021848 ligand binding site [chemical binding]; other site 1246995021849 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1246995021850 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1246995021851 putative sugar binding sites [chemical binding]; other site 1246995021852 Q-X-W motif; other site 1246995021853 Trehalose utilisation; Region: ThuA; pfam06283 1246995021854 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 1246995021855 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1246995021856 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1246995021857 putative sugar binding sites [chemical binding]; other site 1246995021858 Q-X-W motif; other site 1246995021859 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 1246995021860 active site pocket [active] 1246995021861 oxyanion hole [active] 1246995021862 catalytic triad [active] 1246995021863 active site nucleophile [active] 1246995021864 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1246995021865 active site 1246995021866 NTP binding site [chemical binding]; other site 1246995021867 metal binding triad [ion binding]; metal-binding site 1246995021868 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1246995021869 S-adenosylmethionine binding site [chemical binding]; other site 1246995021870 G5 domain; Region: G5; pfam07501 1246995021871 Lamin Tail Domain; Region: LTD; pfam00932 1246995021872 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1246995021873 Predicted flavoprotein [General function prediction only]; Region: COG0431 1246995021874 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1246995021875 MarR family; Region: MarR_2; pfam12802 1246995021876 hypothetical protein; Provisional; Region: PRK07758 1246995021877 Protein of unknown function (DUF402); Region: DUF402; pfam04167 1246995021878 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1246995021879 dimerization interface [polypeptide binding]; other site 1246995021880 putative DNA binding site [nucleotide binding]; other site 1246995021881 putative Zn2+ binding site [ion binding]; other site 1246995021882 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1246995021883 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1246995021884 putative substrate translocation pore; other site 1246995021885 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl15777 1246995021886 putative active site pocket [active] 1246995021887 dimerization interface [polypeptide binding]; other site 1246995021888 putative catalytic residue [active] 1246995021889 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1246995021890 putative active site [active] 1246995021891 GTP-binding protein YchF; Reviewed; Region: PRK09601 1246995021892 YchF GTPase; Region: YchF; cd01900 1246995021893 G1 box; other site 1246995021894 GTP/Mg2+ binding site [chemical binding]; other site 1246995021895 Switch I region; other site 1246995021896 G2 box; other site 1246995021897 Switch II region; other site 1246995021898 G3 box; other site 1246995021899 G4 box; other site 1246995021900 G5 box; other site 1246995021901 Protein of unknown function (DUF933); Region: YchF-GTPase_C; pfam06071 1246995021902 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1246995021903 sequence-specific DNA binding site [nucleotide binding]; other site 1246995021904 salt bridge; other site 1246995021905 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1246995021906 S-adenosylmethionine binding site [chemical binding]; other site 1246995021907 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 1246995021908 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1246995021909 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1246995021910 AlkA N-terminal domain; Region: AlkA_N; pfam06029 1246995021911 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1246995021912 endonuclease III; Region: ENDO3c; smart00478 1246995021913 minor groove reading motif; other site 1246995021914 helix-hairpin-helix signature motif; other site 1246995021915 substrate binding pocket [chemical binding]; other site 1246995021916 active site 1246995021917 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1246995021918 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1246995021919 DNA binding site [nucleotide binding] 1246995021920 active site 1246995021921 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1246995021922 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1246995021923 Pretoxin HINT domain; Region: PT-HINT; pfam07591 1246995021924 thioester formation/cholesterol transfer; other site 1246995021925 protein-splicing catalytic site; other site 1246995021926 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1246995021927 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1246995021928 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 1246995021929 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1246995021930 active site 1246995021931 HIGH motif; other site 1246995021932 nucleotide binding site [chemical binding]; other site 1246995021933 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1246995021934 active site 1246995021935 KMSKS motif; other site 1246995021936 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1246995021937 tRNA binding surface [nucleotide binding]; other site 1246995021938 anticodon binding site; other site 1246995021939 RmuC family; Region: RmuC; pfam02646 1246995021940 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1246995021941 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1246995021942 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1246995021943 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1246995021944 generic binding surface II; other site 1246995021945 generic binding surface I; other site 1246995021946 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1246995021947 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 1246995021948 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1246995021949 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1246995021950 putative active site [active] 1246995021951 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1246995021952 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1246995021953 Rhomboid family; Region: Rhomboid; pfam01694 1246995021954 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 1246995021955 cleavage site 1246995021956 active site 1246995021957 substrate binding sites [chemical binding]; other site 1246995021958 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1246995021959 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1246995021960 catalytic residue [active] 1246995021961 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1246995021962 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 1246995021963 putative active site [active] 1246995021964 PhoH-like protein; Region: PhoH; pfam02562 1246995021965 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1246995021966 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 1246995021967 active site 1246995021968 motif I; other site 1246995021969 motif II; other site 1246995021970 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1246995021971 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1246995021972 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1246995021973 dimerization interface [polypeptide binding]; other site 1246995021974 substrate binding pocket [chemical binding]; other site 1246995021975 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 1246995021976 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 1246995021977 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1246995021978 catalytic residue [active] 1246995021979 putative FPP diphosphate binding site; other site 1246995021980 putative FPP binding hydrophobic cleft; other site 1246995021981 dimer interface [polypeptide binding]; other site 1246995021982 putative IPP diphosphate binding site; other site 1246995021983 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 1246995021984 hypothetical protein; Provisional; Region: PRK07236 1246995021985 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 1246995021986 active site 1246995021987 substrate-binding site [chemical binding]; other site 1246995021988 metal-binding site [ion binding] 1246995021989 GTP binding site [chemical binding]; other site 1246995021990 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1246995021991 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995021992 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1246995021993 DNA binding residues [nucleotide binding] 1246995021994 Predicted membrane protein [Function unknown]; Region: COG2246 1246995021995 GtrA-like protein; Region: GtrA; pfam04138 1246995021996 Predicted membrane protein [Function unknown]; Region: COG2246 1246995021997 GtrA-like protein; Region: GtrA; pfam04138 1246995021998 Bacterial PH domain; Region: DUF304; pfam03703 1246995021999 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1246995022000 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1246995022001 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1246995022002 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1246995022003 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1246995022004 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1246995022005 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 1246995022006 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 1246995022007 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1246995022008 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1246995022009 active site 1246995022010 ATP binding site [chemical binding]; other site 1246995022011 substrate binding site [chemical binding]; other site 1246995022012 activation loop (A-loop); other site 1246995022013 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1246995022014 active site 1246995022015 catalytic residues [active] 1246995022016 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1246995022017 active site 1246995022018 dimer interface [polypeptide binding]; other site 1246995022019 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1246995022020 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1246995022021 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995022022 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1246995022023 Walker A/P-loop; other site 1246995022024 ATP binding site [chemical binding]; other site 1246995022025 Q-loop/lid; other site 1246995022026 ABC transporter signature motif; other site 1246995022027 Walker B; other site 1246995022028 D-loop; other site 1246995022029 H-loop/switch region; other site 1246995022030 Predicted transcriptional regulators [Transcription]; Region: COG1695 1246995022031 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1246995022032 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1246995022033 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1246995022034 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1246995022035 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1246995022036 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1246995022037 carboxyltransferase (CT) interaction site; other site 1246995022038 biotinylation site [posttranslational modification]; other site 1246995022039 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995022040 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995022041 WHG domain; Region: WHG; pfam13305 1246995022042 Predicted membrane protein [Function unknown]; Region: COG4270 1246995022043 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1246995022044 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1246995022045 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1246995022046 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1246995022047 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1246995022048 Uncharacterized conserved protein [Function unknown]; Region: COG2308 1246995022049 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1246995022050 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 1246995022051 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1246995022052 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1246995022053 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1246995022054 putative active site pocket [active] 1246995022055 dimerization interface [polypeptide binding]; other site 1246995022056 putative catalytic residue [active] 1246995022057 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1246995022058 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1246995022059 Coenzyme A binding pocket [chemical binding]; other site 1246995022060 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1246995022061 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 1246995022062 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 1246995022063 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1246995022064 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 1246995022065 metal binding site [ion binding]; metal-binding site 1246995022066 putative dimer interface [polypeptide binding]; other site 1246995022067 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 1246995022068 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1246995022069 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1246995022070 active site 1246995022071 ATP binding site [chemical binding]; other site 1246995022072 substrate binding site [chemical binding]; other site 1246995022073 activation loop (A-loop); other site 1246995022074 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 1246995022075 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1246995022076 active site 1246995022077 substrate binding site [chemical binding]; other site 1246995022078 metal binding site [ion binding]; metal-binding site 1246995022079 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 1246995022080 Domain of unknown function (DUF1792); Region: DUF1792; cl07392 1246995022081 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1246995022082 active site 1246995022083 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1246995022084 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1246995022085 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 1246995022086 putative active site [active] 1246995022087 nucleotide binding site [chemical binding]; other site 1246995022088 nudix motif; other site 1246995022089 putative metal binding site [ion binding]; other site 1246995022090 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1246995022091 active site 1246995022092 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1246995022093 intersubunit interface [polypeptide binding]; other site 1246995022094 active site 1246995022095 catalytic residue [active] 1246995022096 Aldehyde dehydrogenase family 16A1-like; Region: ALDH_F16; cd07111 1246995022097 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1246995022098 NAD(P) binding site [chemical binding]; other site 1246995022099 catalytic residues [active] 1246995022100 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1246995022101 NAD(P) binding site [chemical binding]; other site 1246995022102 Protein of unknown function (DUF4240); Region: DUF4240; pfam14024 1246995022103 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1246995022104 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 1246995022105 G1 box; other site 1246995022106 GTP/Mg2+ binding site [chemical binding]; other site 1246995022107 G2 box; other site 1246995022108 Switch I region; other site 1246995022109 G3 box; other site 1246995022110 Switch II region; other site 1246995022111 G4 box; other site 1246995022112 G5 box; other site 1246995022113 Protein of unknown function (DUF742); Region: DUF742; pfam05331 1246995022114 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 1246995022115 Nitrate and nitrite sensing; Region: NIT; pfam08376 1246995022116 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1246995022117 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995022118 ATP binding site [chemical binding]; other site 1246995022119 Mg2+ binding site [ion binding]; other site 1246995022120 G-X-G motif; other site 1246995022121 adenosine deaminase; Provisional; Region: PRK09358 1246995022122 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1246995022123 active site 1246995022124 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1246995022125 Domain of unknown function (DUF4272); Region: DUF4272; pfam14094 1246995022126 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 1246995022127 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1246995022128 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1246995022129 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 1246995022130 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1246995022131 active site 1246995022132 catalytic motif [active] 1246995022133 Zn binding site [ion binding]; other site 1246995022134 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1246995022135 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1246995022136 TM-ABC transporter signature motif; other site 1246995022137 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1246995022138 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1246995022139 TM-ABC transporter signature motif; other site 1246995022140 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1246995022141 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1246995022142 Walker A/P-loop; other site 1246995022143 ATP binding site [chemical binding]; other site 1246995022144 Q-loop/lid; other site 1246995022145 ABC transporter signature motif; other site 1246995022146 Walker B; other site 1246995022147 D-loop; other site 1246995022148 H-loop/switch region; other site 1246995022149 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1246995022150 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1246995022151 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1246995022152 ligand binding site [chemical binding]; other site 1246995022153 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1246995022154 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1246995022155 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995022156 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995022157 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1246995022158 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 1246995022159 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1246995022160 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 1246995022161 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1246995022162 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1246995022163 active site 1246995022164 HIGH motif; other site 1246995022165 dimer interface [polypeptide binding]; other site 1246995022166 KMSKS motif; other site 1246995022167 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1246995022168 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1246995022169 NAD binding site [chemical binding]; other site 1246995022170 homodimer interface [polypeptide binding]; other site 1246995022171 active site 1246995022172 substrate binding site [chemical binding]; other site 1246995022173 galactokinase; Provisional; Region: PRK05101 1246995022174 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1246995022175 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1246995022176 Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891 1246995022177 putative hydrophobic ligand binding site [chemical binding]; other site 1246995022178 CLM binding site; other site 1246995022179 L1 loop; other site 1246995022180 DNA binding site [nucleotide binding] 1246995022181 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1246995022182 putative DNA binding site [nucleotide binding]; other site 1246995022183 dimerization interface [polypeptide binding]; other site 1246995022184 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1246995022185 putative Zn2+ binding site [ion binding]; other site 1246995022186 Glycosyl hydrolase family 43; Region: GH43_ABN_2; cd08999 1246995022187 putative substrate binding site [chemical binding]; other site 1246995022188 active site 1246995022189 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1246995022190 active site 1246995022191 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1246995022192 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995022193 dimer interface [polypeptide binding]; other site 1246995022194 conserved gate region; other site 1246995022195 putative PBP binding loops; other site 1246995022196 ABC-ATPase subunit interface; other site 1246995022197 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995022198 dimer interface [polypeptide binding]; other site 1246995022199 conserved gate region; other site 1246995022200 putative PBP binding loops; other site 1246995022201 ABC-ATPase subunit interface; other site 1246995022202 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1246995022203 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1246995022204 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 1246995022205 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 1246995022206 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1246995022207 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1246995022208 DNA binding site [nucleotide binding] 1246995022209 domain linker motif; other site 1246995022210 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1246995022211 dimerization interface [polypeptide binding]; other site 1246995022212 ligand binding site [chemical binding]; other site 1246995022213 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 1246995022214 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1246995022215 CysD dimerization site [polypeptide binding]; other site 1246995022216 G1 box; other site 1246995022217 putative GEF interaction site [polypeptide binding]; other site 1246995022218 GTP/Mg2+ binding site [chemical binding]; other site 1246995022219 Switch I region; other site 1246995022220 G2 box; other site 1246995022221 G3 box; other site 1246995022222 Switch II region; other site 1246995022223 G4 box; other site 1246995022224 G5 box; other site 1246995022225 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1246995022226 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1246995022227 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1246995022228 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1246995022229 Active Sites [active] 1246995022230 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1246995022231 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1246995022232 active site 1246995022233 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1246995022234 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1246995022235 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1246995022236 putative active site [active] 1246995022237 catalytic residue [active] 1246995022238 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1246995022239 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1246995022240 5S rRNA interface [nucleotide binding]; other site 1246995022241 CTC domain interface [polypeptide binding]; other site 1246995022242 L16 interface [polypeptide binding]; other site 1246995022243 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1246995022244 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 1246995022245 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1246995022246 active site 1246995022247 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 1246995022248 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1246995022249 Substrate binding site; other site 1246995022250 Mg++ binding site; other site 1246995022251 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1246995022252 active site 1246995022253 substrate binding site [chemical binding]; other site 1246995022254 CoA binding site [chemical binding]; other site 1246995022255 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 1246995022256 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 1246995022257 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1246995022258 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1246995022259 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1246995022260 catalytic site [active] 1246995022261 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 1246995022262 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1246995022263 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1246995022264 active site 1246995022265 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1246995022266 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1246995022267 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 1246995022268 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 1246995022269 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1246995022270 phosphate binding site [ion binding]; other site 1246995022271 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 1246995022272 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1246995022273 phosphate binding site [ion binding]; other site 1246995022274 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1246995022275 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1246995022276 active site 1246995022277 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1246995022278 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1246995022279 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1246995022280 putative NADP binding site [chemical binding]; other site 1246995022281 active site 1246995022282 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995022283 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995022284 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1246995022285 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1246995022286 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1246995022287 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 1246995022288 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1246995022289 putative active site [active] 1246995022290 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1246995022291 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 1246995022292 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1246995022293 active site 1246995022294 polycystin cation channel protein; Region: PCC; TIGR00864 1246995022295 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 1246995022296 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1246995022297 active site 1246995022298 HIGH motif; other site 1246995022299 KMSKS motif; other site 1246995022300 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1246995022301 tRNA binding surface [nucleotide binding]; other site 1246995022302 anticodon binding site; other site 1246995022303 Predicted methyltransferases [General function prediction only]; Region: COG0313 1246995022304 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1246995022305 putative SAM binding site [chemical binding]; other site 1246995022306 putative homodimer interface [polypeptide binding]; other site 1246995022307 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1246995022308 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1246995022309 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1246995022310 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1246995022311 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1246995022312 DXD motif; other site 1246995022313 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1246995022314 GAF domain; Region: GAF; pfam01590 1246995022315 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1246995022316 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995022317 ATP binding site [chemical binding]; other site 1246995022318 Mg2+ binding site [ion binding]; other site 1246995022319 G-X-G motif; other site 1246995022320 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 1246995022321 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 1246995022322 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1246995022323 active site 1246995022324 metal binding site [ion binding]; metal-binding site 1246995022325 hexamer interface [polypeptide binding]; other site 1246995022326 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1246995022327 active site 1246995022328 RibD C-terminal domain; Region: RibD_C; cl17279 1246995022329 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1246995022330 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1246995022331 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1246995022332 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1246995022333 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1246995022334 dimer interface [polypeptide binding]; other site 1246995022335 putative functional site; other site 1246995022336 putative MPT binding site; other site 1246995022337 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1246995022338 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1246995022339 active site 1246995022340 tetramer interface; other site 1246995022341 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1246995022342 dimerization interface [polypeptide binding]; other site 1246995022343 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1246995022344 GAF domain; Region: GAF_3; pfam13492 1246995022345 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1246995022346 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1246995022347 metal binding site [ion binding]; metal-binding site 1246995022348 active site 1246995022349 I-site; other site 1246995022350 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1246995022351 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 1246995022352 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 1246995022353 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1246995022354 metal binding site 2 [ion binding]; metal-binding site 1246995022355 putative DNA binding helix; other site 1246995022356 metal binding site 1 [ion binding]; metal-binding site 1246995022357 dimer interface [polypeptide binding]; other site 1246995022358 structural Zn2+ binding site [ion binding]; other site 1246995022359 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 1246995022360 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1246995022361 DDE superfamily endonuclease; Region: DDE_4; pfam13359 1246995022362 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1246995022363 MarC family integral membrane protein; Region: MarC; cl00919 1246995022364 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 1246995022365 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1246995022366 active site 1246995022367 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1246995022368 Bacterial PH domain; Region: DUF304; pfam03703 1246995022369 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1246995022370 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1246995022371 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1246995022372 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1246995022373 catalytic residues [active] 1246995022374 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1246995022375 protein-splicing catalytic site; other site 1246995022376 thioester formation/cholesterol transfer; other site 1246995022377 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 1246995022378 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 1246995022379 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 1246995022380 CoA binding domain; Region: CoA_binding_2; pfam13380 1246995022381 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 1246995022382 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1246995022383 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995022384 NAD(P) binding site [chemical binding]; other site 1246995022385 active site 1246995022386 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 1246995022387 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1246995022388 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1246995022389 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1246995022390 motif II; other site 1246995022391 Phenazine biosynthesis-like protein; Region: PhzC-PhzF; pfam02567 1246995022392 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1246995022393 MgtE intracellular N domain; Region: MgtE_N; smart00924 1246995022394 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1246995022395 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 1246995022396 Domain of unknown function DUF59; Region: DUF59; pfam01883 1246995022397 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1246995022398 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1246995022399 sec-independent translocase; Provisional; Region: PRK01371 1246995022400 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1246995022401 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1246995022402 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1246995022403 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1246995022404 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1246995022405 S-adenosylmethionine binding site [chemical binding]; other site 1246995022406 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1246995022407 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1246995022408 interface (dimer of trimers) [polypeptide binding]; other site 1246995022409 Substrate-binding/catalytic site; other site 1246995022410 Zn-binding sites [ion binding]; other site 1246995022411 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 1246995022412 PaaX-like protein; Region: PaaX; pfam07848 1246995022413 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 1246995022414 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 1246995022415 enoyl-CoA hydratase; Provisional; Region: PRK06688 1246995022416 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1246995022417 substrate binding site [chemical binding]; other site 1246995022418 oxyanion hole (OAH) forming residues; other site 1246995022419 trimer interface [polypeptide binding]; other site 1246995022420 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 1246995022421 cleavage site 1246995022422 active site 1246995022423 substrate binding sites [chemical binding]; other site 1246995022424 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1246995022425 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1246995022426 hydrophobic ligand binding site; other site 1246995022427 DivIVA domain; Region: DivI1A_domain; TIGR03544 1246995022428 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 1246995022429 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 1246995022430 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1246995022431 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1246995022432 dimer interface [polypeptide binding]; other site 1246995022433 PYR/PP interface [polypeptide binding]; other site 1246995022434 TPP binding site [chemical binding]; other site 1246995022435 substrate binding site [chemical binding]; other site 1246995022436 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 1246995022437 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 1246995022438 TPP-binding site [chemical binding]; other site 1246995022439 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1246995022440 NAD(P) binding site [chemical binding]; other site 1246995022441 catalytic residues [active] 1246995022442 Ion channel; Region: Ion_trans_2; pfam07885 1246995022443 TrkA-N domain; Region: TrkA_N; pfam02254 1246995022444 Prokaryotic phospholipase A2; Region: Phospholip_A2_3; pfam09056 1246995022445 Predicted ATPase [General function prediction only]; Region: COG3903 1246995022446 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 1246995022447 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1246995022448 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1246995022449 catalytic residue [active] 1246995022450 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1246995022451 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 1246995022452 Coenzyme A binding pocket [chemical binding]; other site 1246995022453 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1246995022454 dimer interface [polypeptide binding]; other site 1246995022455 active site 1246995022456 Schiff base residues; other site 1246995022457 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 1246995022458 active site 1246995022459 homodimer interface [polypeptide binding]; other site 1246995022460 SAM binding site [chemical binding]; other site 1246995022461 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1246995022462 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1246995022463 active site 1246995022464 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1246995022465 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 1246995022466 domain interfaces; other site 1246995022467 active site 1246995022468 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1246995022469 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1246995022470 tRNA; other site 1246995022471 putative tRNA binding site [nucleotide binding]; other site 1246995022472 putative NADP binding site [chemical binding]; other site 1246995022473 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1246995022474 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 1246995022475 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 1246995022476 CoA binding domain; Region: CoA_binding; cl17356 1246995022477 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1246995022478 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1246995022479 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 1246995022480 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1246995022481 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 1246995022482 acyl-activating enzyme (AAE) consensus motif; other site 1246995022483 AMP binding site [chemical binding]; other site 1246995022484 active site 1246995022485 CoA binding site [chemical binding]; other site 1246995022486 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 1246995022487 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995022488 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1246995022489 DNA binding residues [nucleotide binding] 1246995022490 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1246995022491 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1246995022492 putative acyl-acceptor binding pocket; other site 1246995022493 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995022494 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1246995022495 NAD(P) binding site [chemical binding]; other site 1246995022496 active site 1246995022497 DNA binding domain, excisionase family; Region: excise; TIGR01764 1246995022498 Proline dehydrogenase; Region: Pro_dh; cl03282 1246995022499 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 1246995022500 CGNR zinc finger; Region: zf-CGNR; pfam11706 1246995022501 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1246995022502 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1246995022503 Metal-binding active site; metal-binding site 1246995022504 Cellulose binding domain; Region: CBM_2; pfam00553 1246995022505 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1246995022506 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995022507 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995022508 light-dependent protochlorophyllide reductase; Region: LPOR; TIGR01289 1246995022509 NAD(P) binding site [chemical binding]; other site 1246995022510 active site 1246995022511 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1246995022512 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995022513 active site 1246995022514 phosphorylation site [posttranslational modification] 1246995022515 intermolecular recognition site; other site 1246995022516 dimerization interface [polypeptide binding]; other site 1246995022517 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1246995022518 DNA binding site [nucleotide binding] 1246995022519 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1246995022520 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1246995022521 dimer interface [polypeptide binding]; other site 1246995022522 phosphorylation site [posttranslational modification] 1246995022523 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995022524 ATP binding site [chemical binding]; other site 1246995022525 Mg2+ binding site [ion binding]; other site 1246995022526 G-X-G motif; other site 1246995022527 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1246995022528 PhoU domain; Region: PhoU; pfam01895 1246995022529 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1246995022530 catalytic core [active] 1246995022531 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1246995022532 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1246995022533 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1246995022534 putative substrate translocation pore; other site 1246995022535 Two component signalling adaptor domain; Region: CheW; smart00260 1246995022536 CheW-like domain; Region: CheW; pfam01584 1246995022537 PAS fold; Region: PAS_4; pfam08448 1246995022538 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1246995022539 PAS domain; Region: PAS_9; pfam13426 1246995022540 putative active site [active] 1246995022541 heme pocket [chemical binding]; other site 1246995022542 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1246995022543 PAS domain; Region: PAS_9; pfam13426 1246995022544 putative active site [active] 1246995022545 heme pocket [chemical binding]; other site 1246995022546 PAS domain; Region: PAS_9; pfam13426 1246995022547 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1246995022548 putative active site [active] 1246995022549 heme pocket [chemical binding]; other site 1246995022550 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1246995022551 PAS domain; Region: PAS_9; pfam13426 1246995022552 putative active site [active] 1246995022553 heme pocket [chemical binding]; other site 1246995022554 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1246995022555 PAS domain; Region: PAS_9; pfam13426 1246995022556 putative active site [active] 1246995022557 heme pocket [chemical binding]; other site 1246995022558 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1246995022559 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1246995022560 dimer interface [polypeptide binding]; other site 1246995022561 putative CheW interface [polypeptide binding]; other site 1246995022562 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1246995022563 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1246995022564 putative substrate translocation pore; other site 1246995022565 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1246995022566 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 1246995022567 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 1246995022568 putative ADP-binding pocket [chemical binding]; other site 1246995022569 malonic semialdehyde reductase; Provisional; Region: PRK10538 1246995022570 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995022571 NAD(P) binding site [chemical binding]; other site 1246995022572 active site 1246995022573 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 1246995022574 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995022575 Response regulator receiver domain; Region: Response_reg; pfam00072 1246995022576 active site 1246995022577 phosphorylation site [posttranslational modification] 1246995022578 intermolecular recognition site; other site 1246995022579 dimerization interface [polypeptide binding]; other site 1246995022580 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1246995022581 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1246995022582 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 1246995022583 calcium binding site 2 [ion binding]; other site 1246995022584 active site 1246995022585 catalytic triad [active] 1246995022586 calcium binding site 1 [ion binding]; other site 1246995022587 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 1246995022588 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1246995022589 PAS domain; Region: PAS_9; pfam13426 1246995022590 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1246995022591 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995022592 ATP binding site [chemical binding]; other site 1246995022593 Mg2+ binding site [ion binding]; other site 1246995022594 G-X-G motif; other site 1246995022595 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 1246995022596 putative hydrophobic ligand binding site [chemical binding]; other site 1246995022597 Histidinol phosphatase and related hydrolases of the PHP family [Amino acid transport and metabolism / General function prediction only]; Region: HIS2; COG1387 1246995022598 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1246995022599 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1246995022600 dimerization interface [polypeptide binding]; other site 1246995022601 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1246995022602 dimer interface [polypeptide binding]; other site 1246995022603 putative CheW interface [polypeptide binding]; other site 1246995022604 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1246995022605 Peptidase family M23; Region: Peptidase_M23; pfam01551 1246995022606 carbon storage regulator; Provisional; Region: PRK01712 1246995022607 FliW protein; Region: FliW; pfam02623 1246995022608 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 1246995022609 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1246995022610 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 1246995022611 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1246995022612 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1246995022613 flagellin; Provisional; Region: PRK12804 1246995022614 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1246995022615 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1246995022616 flagellar capping protein; Reviewed; Region: fliD; PRK08032 1246995022617 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 1246995022618 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1246995022619 Flagellar protein FliS; Region: FliS; cl00654 1246995022620 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 1246995022621 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 1246995022622 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 1246995022623 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 1246995022624 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 1246995022625 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 1246995022626 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 1246995022627 FliG C-terminal domain; Region: FliG_C; pfam01706 1246995022628 Flagellar assembly protein FliH; Region: FliH; pfam02108 1246995022629 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 1246995022630 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 1246995022631 Walker A motif/ATP binding site; other site 1246995022632 Walker B motif; other site 1246995022633 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 1246995022634 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1246995022635 NlpC/P60 family; Region: NLPC_P60; pfam00877 1246995022636 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1246995022637 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1246995022638 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1246995022639 catalytic residue [active] 1246995022640 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 1246995022641 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1246995022642 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 1246995022643 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1246995022644 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 1246995022645 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1246995022646 Flagellar protein (FlbD); Region: FlbD; pfam06289 1246995022647 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 1246995022648 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1246995022649 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 1246995022650 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1246995022651 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1246995022652 ligand binding site [chemical binding]; other site 1246995022653 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 1246995022654 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07718 1246995022655 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 1246995022656 Flagellar motor switch protein FliM; Region: FliM; pfam02154 1246995022657 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1246995022658 flagellar motor switch protein FliN; Region: fliN; TIGR02480 1246995022659 flagellar biosynthetic protein FliO; Region: FliO_TIGR; TIGR03500 1246995022660 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 1246995022661 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 1246995022662 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 1246995022663 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1246995022664 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 1246995022665 FHIPEP family; Region: FHIPEP; pfam00771 1246995022666 flagellar biosynthesis regulator FlhF; Provisional; Region: PRK12723 1246995022667 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1246995022668 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1246995022669 Response regulator receiver domain; Region: Response_reg; pfam00072 1246995022670 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995022671 active site 1246995022672 phosphorylation site [posttranslational modification] 1246995022673 intermolecular recognition site; other site 1246995022674 dimerization interface [polypeptide binding]; other site 1246995022675 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 1246995022676 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995022677 Response regulator receiver domain; Region: Response_reg; pfam00072 1246995022678 active site 1246995022679 phosphorylation site [posttranslational modification] 1246995022680 intermolecular recognition site; other site 1246995022681 dimerization interface [polypeptide binding]; other site 1246995022682 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1246995022683 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1246995022684 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1246995022685 S-adenosylmethionine binding site [chemical binding]; other site 1246995022686 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995022687 active site 1246995022688 phosphorylation site [posttranslational modification] 1246995022689 intermolecular recognition site; other site 1246995022690 dimerization interface [polypeptide binding]; other site 1246995022691 CheB methylesterase; Region: CheB_methylest; pfam01339 1246995022692 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1246995022693 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1246995022694 putative binding surface; other site 1246995022695 active site 1246995022696 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1246995022697 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1246995022698 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995022699 ATP binding site [chemical binding]; other site 1246995022700 Mg2+ binding site [ion binding]; other site 1246995022701 G-X-G motif; other site 1246995022702 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1246995022703 CheW-like domain; Region: CheW; pfam01584 1246995022704 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1246995022705 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995022706 active site 1246995022707 phosphorylation site [posttranslational modification] 1246995022708 intermolecular recognition site; other site 1246995022709 dimerization interface [polypeptide binding]; other site 1246995022710 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1246995022711 DNA binding site [nucleotide binding] 1246995022712 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1246995022713 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1246995022714 dimer interface [polypeptide binding]; other site 1246995022715 phosphorylation site [posttranslational modification] 1246995022716 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1246995022717 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1246995022718 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 1246995022719 FAD binding domain; Region: FAD_binding_4; pfam01565 1246995022720 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1246995022721 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1246995022722 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1246995022723 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 1246995022724 beta-galactosidase; Region: BGL; TIGR03356 1246995022725 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1246995022726 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1246995022727 DNA binding site [nucleotide binding] 1246995022728 domain linker motif; other site 1246995022729 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 1246995022730 putative dimerization interface [polypeptide binding]; other site 1246995022731 putative ligand binding site [chemical binding]; other site 1246995022732 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 1246995022733 putative ADP-ribose binding site [chemical binding]; other site 1246995022734 putative active site [active] 1246995022735 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 1246995022736 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1246995022737 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 1246995022738 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1246995022739 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1246995022740 non-specific DNA binding site [nucleotide binding]; other site 1246995022741 salt bridge; other site 1246995022742 sequence-specific DNA binding site [nucleotide binding]; other site 1246995022743 L-asparaginase II; Region: Asparaginase_II; pfam06089 1246995022744 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 1246995022745 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 1246995022746 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1246995022747 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1246995022748 ferric uptake regulator; Provisional; Region: fur; PRK09462 1246995022749 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1246995022750 metal binding site 2 [ion binding]; metal-binding site 1246995022751 putative DNA binding helix; other site 1246995022752 metal binding site 1 [ion binding]; metal-binding site 1246995022753 dimer interface [polypeptide binding]; other site 1246995022754 structural Zn2+ binding site [ion binding]; other site 1246995022755 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1246995022756 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1246995022757 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1246995022758 catalytic residue [active] 1246995022759 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 1246995022760 heme-binding site [chemical binding]; other site 1246995022761 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 1246995022762 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1246995022763 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995022764 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1246995022765 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 1246995022766 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1246995022767 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1246995022768 active site residue [active] 1246995022769 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1246995022770 active site residue [active] 1246995022771 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1246995022772 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1246995022773 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1246995022774 DNA binding site [nucleotide binding] 1246995022775 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 1246995022776 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1246995022777 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1246995022778 Ligand Binding Site [chemical binding]; other site 1246995022779 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1246995022780 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1246995022781 putative substrate translocation pore; other site 1246995022782 PBP superfamily domain; Region: PBP_like_2; cl17296 1246995022783 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 1246995022784 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995022785 dimer interface [polypeptide binding]; other site 1246995022786 conserved gate region; other site 1246995022787 putative PBP binding loops; other site 1246995022788 ABC-ATPase subunit interface; other site 1246995022789 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 1246995022790 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995022791 dimer interface [polypeptide binding]; other site 1246995022792 conserved gate region; other site 1246995022793 ABC-ATPase subunit interface; other site 1246995022794 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 1246995022795 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1246995022796 Walker A/P-loop; other site 1246995022797 ATP binding site [chemical binding]; other site 1246995022798 Q-loop/lid; other site 1246995022799 ABC transporter signature motif; other site 1246995022800 Walker B; other site 1246995022801 D-loop; other site 1246995022802 H-loop/switch region; other site 1246995022803 NUDIX domain; Region: NUDIX; pfam00293 1246995022804 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1246995022805 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1246995022806 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1246995022807 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 1246995022808 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1246995022809 catalytic site [active] 1246995022810 active site 1246995022811 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 1246995022812 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995022813 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1246995022814 DNA binding residues [nucleotide binding] 1246995022815 SnoaL-like domain; Region: SnoaL_2; pfam12680 1246995022816 Protein of unknown function (DUF402); Region: DUF402; pfam04167 1246995022817 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1246995022818 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 1246995022819 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1246995022820 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1246995022821 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1246995022822 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1246995022823 oligomerisation interface [polypeptide binding]; other site 1246995022824 mobile loop; other site 1246995022825 roof hairpin; other site 1246995022826 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1246995022827 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1246995022828 S-adenosylmethionine binding site [chemical binding]; other site 1246995022829 Protease prsW family; Region: PrsW-protease; pfam13367 1246995022830 Predicted membrane protein [Function unknown]; Region: COG4129 1246995022831 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339 1246995022832 Protein of unknown function (DUF4031); Region: DUF4031; pfam13223 1246995022833 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1246995022834 Predicted transcriptional regulators [Transcription]; Region: COG1733 1246995022835 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1246995022836 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1246995022837 catalytic triad [active] 1246995022838 H+ Antiporter protein; Region: 2A0121; TIGR00900 1246995022839 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1246995022840 putative substrate translocation pore; other site 1246995022841 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1246995022842 Coenzyme A binding pocket [chemical binding]; other site 1246995022843 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1246995022844 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1246995022845 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1246995022846 ring oligomerisation interface [polypeptide binding]; other site 1246995022847 ATP/Mg binding site [chemical binding]; other site 1246995022848 stacking interactions; other site 1246995022849 hinge regions; other site 1246995022850 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1246995022851 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1246995022852 Coenzyme A binding pocket [chemical binding]; other site 1246995022853 threonine synthase; Validated; Region: PRK08197 1246995022854 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1246995022855 homodimer interface [polypeptide binding]; other site 1246995022856 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1246995022857 catalytic residue [active] 1246995022858 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1246995022859 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995022860 Walker A/P-loop; other site 1246995022861 ATP binding site [chemical binding]; other site 1246995022862 Q-loop/lid; other site 1246995022863 ABC transporter signature motif; other site 1246995022864 Walker B; other site 1246995022865 D-loop; other site 1246995022866 H-loop/switch region; other site 1246995022867 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 1246995022868 AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243 1246995022869 ATPase family associated with various cellular activities (AAA); Region: AAA; pfam00004 1246995022870 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1246995022871 Walker A motif; other site 1246995022872 ATP binding site [chemical binding]; other site 1246995022873 Walker B motif; other site 1246995022874 arginine finger; other site 1246995022875 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1246995022876 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 1246995022877 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1246995022878 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995022879 Walker A/P-loop; other site 1246995022880 ATP binding site [chemical binding]; other site 1246995022881 Q-loop/lid; other site 1246995022882 ABC transporter signature motif; other site 1246995022883 Walker B; other site 1246995022884 D-loop; other site 1246995022885 H-loop/switch region; other site 1246995022886 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 1246995022887 Domain of unknown function (DUF305); Region: DUF305; pfam03713 1246995022888 Chitin binding domain; Region: Chitin_bind_3; pfam03067 1246995022889 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 1246995022890 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1246995022891 dimerization interface [polypeptide binding]; other site 1246995022892 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 1246995022893 ATP binding site [chemical binding]; other site 1246995022894 Mg2+ binding site [ion binding]; other site 1246995022895 G-X-G motif; other site 1246995022896 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1246995022897 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995022898 active site 1246995022899 phosphorylation site [posttranslational modification] 1246995022900 intermolecular recognition site; other site 1246995022901 dimerization interface [polypeptide binding]; other site 1246995022902 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1246995022903 DNA binding site [nucleotide binding] 1246995022904 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1246995022905 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1246995022906 active site 1246995022907 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_7; cd05844 1246995022908 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1246995022909 putative ADP-binding pocket [chemical binding]; other site 1246995022910 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1246995022911 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1246995022912 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1246995022913 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1246995022914 dimer interface [polypeptide binding]; other site 1246995022915 active site 1246995022916 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1246995022917 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1246995022918 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1246995022919 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1246995022920 Amidohydrolase; Region: Amidohydro_4; pfam13147 1246995022921 active site 1246995022922 dimer interface [polypeptide binding]; other site 1246995022923 SnoaL-like domain; Region: SnoaL_4; pfam13577 1246995022924 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1246995022925 active site 1246995022926 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1246995022927 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 1246995022928 TrkA-N domain; Region: TrkA_N; pfam02254 1246995022929 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1246995022930 TrkA-N domain; Region: TrkA_N; pfam02254 1246995022931 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1246995022932 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1246995022933 active site 1246995022934 catalytic residues [active] 1246995022935 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 1246995022936 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 1246995022937 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1246995022938 Coenzyme A binding pocket [chemical binding]; other site 1246995022939 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1246995022940 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1246995022941 Walker A/P-loop; other site 1246995022942 ATP binding site [chemical binding]; other site 1246995022943 Q-loop/lid; other site 1246995022944 ABC transporter signature motif; other site 1246995022945 Walker B; other site 1246995022946 D-loop; other site 1246995022947 H-loop/switch region; other site 1246995022948 TOBE domain; Region: TOBE_2; pfam08402 1246995022949 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 1246995022950 nucleotide binding site [chemical binding]; other site 1246995022951 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1246995022952 SBD interface [polypeptide binding]; other site 1246995022953 PQQ-like domain; Region: PQQ_2; pfam13360 1246995022954 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1246995022955 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1246995022956 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1246995022957 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1246995022958 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1246995022959 active site 1246995022960 HIGH motif; other site 1246995022961 nucleotide binding site [chemical binding]; other site 1246995022962 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1246995022963 KMSKS motif; other site 1246995022964 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1246995022965 tRNA binding surface [nucleotide binding]; other site 1246995022966 anticodon binding site; other site 1246995022967 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1246995022968 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1246995022969 putative active site [active] 1246995022970 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1246995022971 active site 1246995022972 catalytic residues [active] 1246995022973 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1246995022974 Class II fumarases; Region: Fumarase_classII; cd01362 1246995022975 active site 1246995022976 tetramer interface [polypeptide binding]; other site 1246995022977 fumarate hydratase; Provisional; Region: PRK15389 1246995022978 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 1246995022979 Fumarase C-terminus; Region: Fumerase_C; pfam05683 1246995022980 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 1246995022981 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1246995022982 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1246995022983 AsnC family; Region: AsnC_trans_reg; pfam01037 1246995022984 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 1246995022985 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 1246995022986 dimer interface [polypeptide binding]; other site 1246995022987 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 1246995022988 active site 1246995022989 Fe binding site [ion binding]; other site 1246995022990 RDD family; Region: RDD; pfam06271 1246995022991 RDD family; Region: RDD; pfam06271 1246995022992 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 1246995022993 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1246995022994 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1246995022995 homodimer interface [polypeptide binding]; other site 1246995022996 catalytic residue [active] 1246995022997 FtsX-like permease family; Region: FtsX; pfam02687 1246995022998 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1246995022999 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1246995023000 Walker A/P-loop; other site 1246995023001 ATP binding site [chemical binding]; other site 1246995023002 Q-loop/lid; other site 1246995023003 ABC transporter signature motif; other site 1246995023004 Walker B; other site 1246995023005 D-loop; other site 1246995023006 H-loop/switch region; other site 1246995023007 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1246995023008 Histidine kinase; Region: HisKA_3; pfam07730 1246995023009 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995023010 ATP binding site [chemical binding]; other site 1246995023011 Mg2+ binding site [ion binding]; other site 1246995023012 G-X-G motif; other site 1246995023013 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1246995023014 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995023015 active site 1246995023016 phosphorylation site [posttranslational modification] 1246995023017 intermolecular recognition site; other site 1246995023018 dimerization interface [polypeptide binding]; other site 1246995023019 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1246995023020 DNA binding residues [nucleotide binding] 1246995023021 dimerization interface [polypeptide binding]; other site 1246995023022 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1246995023023 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1246995023024 putative substrate translocation pore; other site 1246995023025 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1246995023026 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1246995023027 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1246995023028 active site 1246995023029 PQQ-like domain; Region: PQQ_2; pfam13360 1246995023030 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1246995023031 hydrophobic ligand binding site; other site 1246995023032 fumarylacetoacetase; Region: PLN02856 1246995023033 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 1246995023034 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1246995023035 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 1246995023036 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1246995023037 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1246995023038 putative sugar binding sites [chemical binding]; other site 1246995023039 Q-X-W motif; other site 1246995023040 Glycosyl hydrolase family 46 chitosanase domain. This family are composed of the chitosanase enzymes which hydrolyzes chitosan, a biopolymer of beta (1,4)-linked -D-glucosamine (GlcN) residues produced by partial or full deacetylation of chitin; Region: chitosanase_glyco_hydro_46; cd00978 1246995023041 chitosan binding site [chemical binding]; other site 1246995023042 catalytic residues [active] 1246995023043 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 1246995023044 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1246995023045 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1246995023046 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1246995023047 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1246995023048 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1246995023049 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995023050 dimer interface [polypeptide binding]; other site 1246995023051 conserved gate region; other site 1246995023052 ABC-ATPase subunit interface; other site 1246995023053 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1246995023054 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995023055 dimer interface [polypeptide binding]; other site 1246995023056 conserved gate region; other site 1246995023057 putative PBP binding loops; other site 1246995023058 ABC-ATPase subunit interface; other site 1246995023059 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1246995023060 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 1246995023061 NAD binding site [chemical binding]; other site 1246995023062 sugar binding site [chemical binding]; other site 1246995023063 divalent metal binding site [ion binding]; other site 1246995023064 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1246995023065 dimer interface [polypeptide binding]; other site 1246995023066 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1246995023067 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1246995023068 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1246995023069 homotrimer interaction site [polypeptide binding]; other site 1246995023070 zinc binding site [ion binding]; other site 1246995023071 CDP-binding sites; other site 1246995023072 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1246995023073 dimer interface; other site 1246995023074 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 1246995023075 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 1246995023076 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 1246995023077 malonyl-CoA binding site [chemical binding]; other site 1246995023078 dimer interface [polypeptide binding]; other site 1246995023079 active site 1246995023080 product binding site; other site 1246995023081 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1246995023082 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1246995023083 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1246995023084 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1246995023085 S-adenosylmethionine binding site [chemical binding]; other site 1246995023086 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 1246995023087 UbiA prenyltransferase family; Region: UbiA; pfam01040 1246995023088 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1246995023089 Walker A motif; other site 1246995023090 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1246995023091 ATP binding site [chemical binding]; other site 1246995023092 Walker B motif; other site 1246995023093 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 1246995023094 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1246995023095 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 1246995023096 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1246995023097 active site 1246995023098 catalytic residues [active] 1246995023099 metal binding site [ion binding]; metal-binding site 1246995023100 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1246995023101 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 1246995023102 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1246995023103 endonuclease III; Region: ENDO3c; smart00478 1246995023104 minor groove reading motif; other site 1246995023105 helix-hairpin-helix signature motif; other site 1246995023106 substrate binding pocket [chemical binding]; other site 1246995023107 active site 1246995023108 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1246995023109 Domain of unknown function (DUF4291); Region: DUF4291; pfam14124 1246995023110 Clp protease ATP binding subunit; Region: clpC; CHL00095 1246995023111 Clp amino terminal domain; Region: Clp_N; pfam02861 1246995023112 Clp amino terminal domain; Region: Clp_N; pfam02861 1246995023113 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1246995023114 Walker A motif; other site 1246995023115 ATP binding site [chemical binding]; other site 1246995023116 Walker B motif; other site 1246995023117 arginine finger; other site 1246995023118 UvrB/uvrC motif; Region: UVR; pfam02151 1246995023119 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1246995023120 Walker A motif; other site 1246995023121 ATP binding site [chemical binding]; other site 1246995023122 Walker B motif; other site 1246995023123 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1246995023124 Lsr2; Region: Lsr2; pfam11774 1246995023125 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1246995023126 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1246995023127 dimer interface [polypeptide binding]; other site 1246995023128 putative anticodon binding site; other site 1246995023129 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1246995023130 motif 1; other site 1246995023131 dimer interface [polypeptide binding]; other site 1246995023132 active site 1246995023133 motif 2; other site 1246995023134 motif 3; other site 1246995023135 pantothenate kinase; Reviewed; Region: PRK13318 1246995023136 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 1246995023137 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1246995023138 dimerization interface [polypeptide binding]; other site 1246995023139 active site 1246995023140 L-aspartate oxidase; Provisional; Region: PRK07804 1246995023141 L-aspartate oxidase; Provisional; Region: PRK06175 1246995023142 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1246995023143 Septum formation; Region: Septum_form; pfam13845 1246995023144 pantoate--beta-alanine ligase; Reviewed; Region: panC; PRK00380 1246995023145 active site 1246995023146 nucleotide binding site [chemical binding]; other site 1246995023147 HIGH motif; other site 1246995023148 KMSKS motif; other site 1246995023149 Rossmann-like domain; Region: Rossmann-like; pfam10727 1246995023150 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 1246995023151 Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636 1246995023152 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 1246995023153 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 1246995023154 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1246995023155 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995023156 ABC-ATPase subunit interface; other site 1246995023157 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995023158 ABC-ATPase subunit interface; other site 1246995023159 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1246995023160 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1246995023161 Walker A/P-loop; other site 1246995023162 ATP binding site [chemical binding]; other site 1246995023163 Q-loop/lid; other site 1246995023164 ABC transporter signature motif; other site 1246995023165 Walker B; other site 1246995023166 D-loop; other site 1246995023167 H-loop/switch region; other site 1246995023168 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1246995023169 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 1246995023170 TM-ABC transporter signature motif; other site 1246995023171 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 1246995023172 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1246995023173 catalytic center binding site [active] 1246995023174 ATP binding site [chemical binding]; other site 1246995023175 Dihydroneopterin aldolase; Region: FolB; smart00905 1246995023176 active site 1246995023177 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1246995023178 dihydropteroate synthase; Region: DHPS; TIGR01496 1246995023179 substrate binding pocket [chemical binding]; other site 1246995023180 dimer interface [polypeptide binding]; other site 1246995023181 inhibitor binding site; inhibition site 1246995023182 AAA-like domain; Region: AAA_10; pfam12846 1246995023183 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1246995023184 Peptidase family M23; Region: Peptidase_M23; pfam01551 1246995023185 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1246995023186 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1246995023187 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1246995023188 homotrimer interaction site [polypeptide binding]; other site 1246995023189 putative active site [active] 1246995023190 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 1246995023191 active site 1246995023192 FtsH Extracellular; Region: FtsH_ext; pfam06480 1246995023193 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1246995023194 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1246995023195 Walker A motif; other site 1246995023196 ATP binding site [chemical binding]; other site 1246995023197 Walker B motif; other site 1246995023198 arginine finger; other site 1246995023199 Peptidase family M41; Region: Peptidase_M41; pfam01434 1246995023200 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1246995023201 active site 1246995023202 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1246995023203 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1246995023204 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 1246995023205 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 1246995023206 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 1246995023207 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1246995023208 dimer interface [polypeptide binding]; other site 1246995023209 substrate binding site [chemical binding]; other site 1246995023210 metal binding sites [ion binding]; metal-binding site 1246995023211 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 1246995023212 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1246995023213 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1246995023214 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1246995023215 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1246995023216 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1246995023217 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1246995023218 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 1246995023219 active site 1246995023220 catalytic residues [active] 1246995023221 Colicin V production protein; Region: Colicin_V; pfam02674 1246995023222 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1246995023223 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1246995023224 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1246995023225 putative active site [active] 1246995023226 putative CoA binding site [chemical binding]; other site 1246995023227 nudix motif; other site 1246995023228 metal binding site [ion binding]; metal-binding site 1246995023229 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1246995023230 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1246995023231 catalytic residues [active] 1246995023232 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1246995023233 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1246995023234 minor groove reading motif; other site 1246995023235 helix-hairpin-helix signature motif; other site 1246995023236 substrate binding pocket [chemical binding]; other site 1246995023237 active site 1246995023238 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1246995023239 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 1246995023240 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1246995023241 putative active site [active] 1246995023242 putative metal binding site [ion binding]; other site 1246995023243 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1246995023244 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1246995023245 ligand binding site [chemical binding]; other site 1246995023246 flexible hinge region; other site 1246995023247 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1246995023248 non-specific DNA interactions [nucleotide binding]; other site 1246995023249 DNA binding site [nucleotide binding] 1246995023250 sequence specific DNA binding site [nucleotide binding]; other site 1246995023251 putative cAMP binding site [chemical binding]; other site 1246995023252 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1246995023253 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1246995023254 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1246995023255 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1246995023256 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1246995023257 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1246995023258 carboxyltransferase (CT) interaction site; other site 1246995023259 biotinylation site [posttranslational modification]; other site 1246995023260 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1246995023261 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1246995023262 active site 1246995023263 ATP binding site [chemical binding]; other site 1246995023264 substrate binding site [chemical binding]; other site 1246995023265 activation loop (A-loop); other site 1246995023266 Septum formation; Region: Septum_form; pfam13845 1246995023267 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1246995023268 cyclase homology domain; Region: CHD; cd07302 1246995023269 nucleotidyl binding site; other site 1246995023270 metal binding site [ion binding]; metal-binding site 1246995023271 dimer interface [polypeptide binding]; other site 1246995023272 Predicted ATPase [General function prediction only]; Region: COG3899 1246995023273 AAA ATPase domain; Region: AAA_16; pfam13191 1246995023274 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1246995023275 TPR motif; other site 1246995023276 binding surface 1246995023277 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1246995023278 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 1246995023279 homotrimer interaction site [polypeptide binding]; other site 1246995023280 putative active site [active] 1246995023281 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 1246995023282 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 1246995023283 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1246995023284 DTAP/Switch II; other site 1246995023285 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 1246995023286 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1246995023287 DTAP/Switch II; other site 1246995023288 Switch I; other site 1246995023289 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1246995023290 Transcription factor WhiB; Region: Whib; pfam02467 1246995023291 Transglycosylase; Region: Transgly; pfam00912 1246995023292 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1246995023293 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1246995023294 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 1246995023295 Yqey-like protein; Region: YqeY; pfam09424 1246995023296 phosphodiesterase YaeI; Provisional; Region: PRK11340 1246995023297 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1246995023298 putative active site [active] 1246995023299 putative metal binding site [ion binding]; other site 1246995023300 H+ Antiporter protein; Region: 2A0121; TIGR00900 1246995023301 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1246995023302 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1246995023303 dimerization interface [polypeptide binding]; other site 1246995023304 putative DNA binding site [nucleotide binding]; other site 1246995023305 putative Zn2+ binding site [ion binding]; other site 1246995023306 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1246995023307 active site 1246995023308 Uncharacterized conserved protein [Function unknown]; Region: COG3287 1246995023309 FIST N domain; Region: FIST; pfam08495 1246995023310 FIST C domain; Region: FIST_C; pfam10442 1246995023311 GAF domain; Region: GAF_3; pfam13492 1246995023312 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1246995023313 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1246995023314 metal binding site [ion binding]; metal-binding site 1246995023315 active site 1246995023316 I-site; other site 1246995023317 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1246995023318 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 1246995023319 aromatic chitin/cellulose binding site residues [chemical binding]; other site 1246995023320 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 1246995023321 aromatic chitin/cellulose binding site residues [chemical binding]; other site 1246995023322 Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but some...; Region: chitinase_glyco_hydro_19; cd00325 1246995023323 putative sugar binding site [chemical binding]; other site 1246995023324 catalytic residues [active] 1246995023325 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1246995023326 dimer interface [polypeptide binding]; other site 1246995023327 putative CheW interface [polypeptide binding]; other site 1246995023328 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1246995023329 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1246995023330 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1246995023331 aspartate kinase; Reviewed; Region: PRK06635 1246995023332 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1246995023333 putative nucleotide binding site [chemical binding]; other site 1246995023334 putative catalytic residues [active] 1246995023335 putative Mg ion binding site [ion binding]; other site 1246995023336 putative aspartate binding site [chemical binding]; other site 1246995023337 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1246995023338 putative allosteric regulatory site; other site 1246995023339 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1246995023340 putative allosteric regulatory residue; other site 1246995023341 2-isopropylmalate synthase; Validated; Region: PRK03739 1246995023342 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1246995023343 active site 1246995023344 catalytic residues [active] 1246995023345 metal binding site [ion binding]; metal-binding site 1246995023346 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1246995023347 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1246995023348 A subgroup of the Glycosyl hydrolase family 20 (GH20) catalytic domain found in proteins similar to the N-acetylhexosaminidase from Streptomyces plicatus (SpHex). SpHex catalyzes the hydrolysis of N-acetyl-beta-hexosaminides. An Asp residue within the...; Region: GH20_SpHex_like; cd06568 1246995023349 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 1246995023350 active site 1246995023351 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1246995023352 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1246995023353 Walker A/P-loop; other site 1246995023354 ATP binding site [chemical binding]; other site 1246995023355 Q-loop/lid; other site 1246995023356 ABC transporter signature motif; other site 1246995023357 Walker B; other site 1246995023358 D-loop; other site 1246995023359 H-loop/switch region; other site 1246995023360 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1246995023361 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1246995023362 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1246995023363 Walker A/P-loop; other site 1246995023364 ATP binding site [chemical binding]; other site 1246995023365 Q-loop/lid; other site 1246995023366 ABC transporter signature motif; other site 1246995023367 Walker B; other site 1246995023368 D-loop; other site 1246995023369 H-loop/switch region; other site 1246995023370 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1246995023371 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1246995023372 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995023373 dimer interface [polypeptide binding]; other site 1246995023374 conserved gate region; other site 1246995023375 putative PBP binding loops; other site 1246995023376 ABC-ATPase subunit interface; other site 1246995023377 The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506 1246995023378 peptide binding site [polypeptide binding]; other site 1246995023379 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1246995023380 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1246995023381 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1246995023382 dimer interface [polypeptide binding]; other site 1246995023383 conserved gate region; other site 1246995023384 putative PBP binding loops; other site 1246995023385 ABC-ATPase subunit interface; other site 1246995023386 recombination protein RecR; Reviewed; Region: recR; PRK00076 1246995023387 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1246995023388 RecR protein; Region: RecR; pfam02132 1246995023389 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1246995023390 putative active site [active] 1246995023391 putative metal-binding site [ion binding]; other site 1246995023392 tetramer interface [polypeptide binding]; other site 1246995023393 hypothetical protein; Validated; Region: PRK00153 1246995023394 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 1246995023395 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1246995023396 Walker A motif; other site 1246995023397 ATP binding site [chemical binding]; other site 1246995023398 Walker B motif; other site 1246995023399 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1246995023400 H+ Antiporter protein; Region: 2A0121; TIGR00900 1246995023401 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1246995023402 dimerization interface [polypeptide binding]; other site 1246995023403 putative DNA binding site [nucleotide binding]; other site 1246995023404 putative Zn2+ binding site [ion binding]; other site 1246995023405 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1246995023406 anti sigma factor interaction site; other site 1246995023407 regulatory phosphorylation site [posttranslational modification]; other site 1246995023408 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1246995023409 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1246995023410 transmembrane helices; other site 1246995023411 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1246995023412 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 1246995023413 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 1246995023414 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1246995023415 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1246995023416 nucleoside/Zn binding site; other site 1246995023417 dimer interface [polypeptide binding]; other site 1246995023418 catalytic motif [active] 1246995023419 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 1246995023420 Peptidase family M23; Region: Peptidase_M23; pfam01551 1246995023421 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1246995023422 prephenate dehydrogenase; Validated; Region: PRK08507 1246995023423 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1246995023424 DinB superfamily; Region: DinB_2; pfam12867 1246995023425 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 1246995023426 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 1246995023427 hypothetical protein; Provisional; Region: PRK07945 1246995023428 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 1246995023429 active site 1246995023430 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 1246995023431 Nitrate and nitrite sensing; Region: NIT; pfam08376 1246995023432 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995023433 ATP binding site [chemical binding]; other site 1246995023434 Mg2+ binding site [ion binding]; other site 1246995023435 G-X-G motif; other site 1246995023436 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 1246995023437 Protein of unknown function (DUF742); Region: DUF742; pfam05331 1246995023438 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1246995023439 ATPase involved in DNA repair; Region: DUF3686; pfam12458 1246995023440 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1246995023441 AAA domain; Region: AAA_22; pfam13401 1246995023442 Walker A motif; other site 1246995023443 ATP binding site [chemical binding]; other site 1246995023444 Walker B motif; other site 1246995023445 arginine finger; other site 1246995023446 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 1246995023447 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 1246995023448 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1246995023449 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1246995023450 active site 1246995023451 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1246995023452 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 1246995023453 active site 1246995023454 homodimer interface [polypeptide binding]; other site 1246995023455 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1246995023456 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 1246995023457 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cl15820 1246995023458 putative sugar binding sites [chemical binding]; other site 1246995023459 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1246995023460 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1246995023461 putative sugar binding sites [chemical binding]; other site 1246995023462 Q-X-W motif; other site 1246995023463 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1246995023464 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1246995023465 Cellulose binding domain; Region: CBM_2; pfam00553 1246995023466 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 1246995023467 active site 1246995023468 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1246995023469 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995023470 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1246995023471 MarR family; Region: MarR; pfam01047 1246995023472 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1246995023473 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1246995023474 putative substrate translocation pore; other site 1246995023475 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1246995023476 AAA domain; Region: AAA_33; pfam13671 1246995023477 AAA domain; Region: AAA_17; pfam13207 1246995023478 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1246995023479 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1246995023480 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1246995023481 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1246995023482 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1246995023483 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1246995023484 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1246995023485 metal binding site [ion binding]; metal-binding site 1246995023486 active site 1246995023487 I-site; other site 1246995023488 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 1246995023489 Domain of unknown function (DUF397); Region: DUF397; pfam04149 1246995023490 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1246995023491 non-specific DNA binding site [nucleotide binding]; other site 1246995023492 salt bridge; other site 1246995023493 sequence-specific DNA binding site [nucleotide binding]; other site 1246995023494 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 1246995023495 homotrimer interaction site [polypeptide binding]; other site 1246995023496 putative active site [active] 1246995023497 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1246995023498 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1246995023499 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1246995023500 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1246995023501 dimerization interface [polypeptide binding]; other site 1246995023502 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1246995023503 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 1246995023504 ATP binding site [chemical binding]; other site 1246995023505 active site 1246995023506 substrate binding site [chemical binding]; other site 1246995023507 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b1; cd09203 1246995023508 PLD-like domain; Region: PLDc_2; pfam13091 1246995023509 putative homodimer interface [polypeptide binding]; other site 1246995023510 putative active site [active] 1246995023511 catalytic site [active] 1246995023512 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1246995023513 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1246995023514 ATP binding site [chemical binding]; other site 1246995023515 putative Mg++ binding site [ion binding]; other site 1246995023516 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1246995023517 nucleotide binding region [chemical binding]; other site 1246995023518 ATP-binding site [chemical binding]; other site 1246995023519 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 1246995023520 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1246995023521 active site 1246995023522 PQQ-like domain; Region: PQQ_2; pfam13360 1246995023523 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 1246995023524 generic binding surface II; other site 1246995023525 generic binding surface I; other site 1246995023526 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 1246995023527 putative active site [active] 1246995023528 putative catalytic site [active] 1246995023529 putative Mg binding site IVb [ion binding]; other site 1246995023530 putative phosphate binding site [ion binding]; other site 1246995023531 putative DNA binding site [nucleotide binding]; other site 1246995023532 putative Mg binding site IVa [ion binding]; other site 1246995023533 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 1246995023534 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 1246995023535 putative active site [active] 1246995023536 putative metal binding site [ion binding]; other site 1246995023537 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1246995023538 Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Region: PKD; smart00089 1246995023539 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 1246995023540 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 1246995023541 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 1246995023542 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1246995023543 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1246995023544 Walker A/P-loop; other site 1246995023545 ATP binding site [chemical binding]; other site 1246995023546 Q-loop/lid; other site 1246995023547 ABC transporter signature motif; other site 1246995023548 Walker B; other site 1246995023549 D-loop; other site 1246995023550 H-loop/switch region; other site 1246995023551 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1246995023552 DNA-binding site [nucleotide binding]; DNA binding site 1246995023553 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1246995023554 DNA binding residues [nucleotide binding] 1246995023555 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 1246995023556 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1246995023557 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1246995023558 sequence-specific DNA binding site [nucleotide binding]; other site 1246995023559 salt bridge; other site 1246995023560 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1246995023561 Predicted ATPase [General function prediction only]; Region: COG3903 1246995023562 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1246995023563 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1246995023564 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1246995023565 TPR motif; other site 1246995023566 binding surface 1246995023567 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1246995023568 CAAX protease self-immunity; Region: Abi; pfam02517 1246995023569 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1246995023570 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1246995023571 heme-binding site [chemical binding]; other site 1246995023572 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 1246995023573 FAD binding pocket [chemical binding]; other site 1246995023574 FAD binding motif [chemical binding]; other site 1246995023575 phosphate binding motif [ion binding]; other site 1246995023576 beta-alpha-beta structure motif; other site 1246995023577 NAD binding pocket [chemical binding]; other site 1246995023578 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1246995023579 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1246995023580 non-specific DNA binding site [nucleotide binding]; other site 1246995023581 salt bridge; other site 1246995023582 sequence-specific DNA binding site [nucleotide binding]; other site 1246995023583 Polypeptide deformylase; Region: Pep_deformylase; pfam01327 1246995023584 active site 1246995023585 catalytic residues [active] 1246995023586 metal binding site [ion binding]; metal-binding site 1246995023587 siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951 1246995023588 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1246995023589 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1246995023590 S-adenosylmethionine binding site [chemical binding]; other site 1246995023591 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1246995023592 substrate binding site [chemical binding]; other site 1246995023593 GAF domain; Region: GAF; pfam01590 1246995023594 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1246995023595 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1246995023596 dimer interface [polypeptide binding]; other site 1246995023597 phosphorylation site [posttranslational modification] 1246995023598 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995023599 ATP binding site [chemical binding]; other site 1246995023600 Mg2+ binding site [ion binding]; other site 1246995023601 G-X-G motif; other site 1246995023602 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1246995023603 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1246995023604 NlpC/P60 family; Region: NLPC_P60; cl17555 1246995023605 YCII-related domain; Region: YCII; cl00999 1246995023606 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 1246995023607 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995023608 TIGR02452 family protein; Region: TIGR02452 1246995023609 Uncharacterized protein conserved in bacteria (DUF2263); Region: DUF2263; pfam10021 1246995023610 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1246995023611 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1246995023612 active site 1246995023613 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1246995023614 Predicted flavoprotein [General function prediction only]; Region: COG0431 1246995023615 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 1246995023616 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 1246995023617 DNA binding residues [nucleotide binding] 1246995023618 dimer interface [polypeptide binding]; other site 1246995023619 [2Fe-2S] cluster binding site [ion binding]; other site 1246995023620 Predicted transcriptional regulators [Transcription]; Region: COG1695 1246995023621 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1246995023622 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1246995023623 Predicted transcriptional regulators [Transcription]; Region: COG1695 1246995023624 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1246995023625 AAA domain; Region: AAA_21; pfam13304 1246995023626 Walker A/P-loop; other site 1246995023627 ATP binding site [chemical binding]; other site 1246995023628 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 1246995023629 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 1246995023630 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 1246995023631 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1246995023632 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1246995023633 putative sugar binding sites [chemical binding]; other site 1246995023634 Q-X-W motif; other site 1246995023635 Ricin-type beta-trefoil; Region: RICIN; smart00458 1246995023636 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1246995023637 putative sugar binding sites [chemical binding]; other site 1246995023638 Q-X-W motif; other site 1246995023639 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 1246995023640 active site 1246995023641 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 1246995023642 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1246995023643 NAD(P) binding site [chemical binding]; other site 1246995023644 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 1246995023645 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 1246995023646 DNA binding residues [nucleotide binding] 1246995023647 dimer interface [polypeptide binding]; other site 1246995023648 [2Fe-2S] cluster binding site [ion binding]; other site 1246995023649 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1246995023650 TPP-binding site [chemical binding]; other site 1246995023651 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1246995023652 PYR/PP interface [polypeptide binding]; other site 1246995023653 dimer interface [polypeptide binding]; other site 1246995023654 TPP binding site [chemical binding]; other site 1246995023655 Winged helix-turn helix; Region: HTH_29; pfam13551 1246995023656 Homeodomain-like domain; Region: HTH_23; cl17451 1246995023657 Integrase core domain; Region: rve; pfam00665 1246995023658 Integrase core domain; Region: rve_3; pfam13683 1246995023659 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 1246995023660 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1246995023661 dimer interface [polypeptide binding]; other site 1246995023662 active site 1246995023663 B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction; Region: BBOX; cl00034 1246995023664 Rhomboid family; Region: Rhomboid; pfam01694 1246995023665 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1246995023666 active site 1246995023667 Protein of unknown function (DUF690); Region: DUF690; cl04939 1246995023668 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1246995023669 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 1246995023670 oligomer interface [polypeptide binding]; other site 1246995023671 metal binding site [ion binding]; metal-binding site 1246995023672 metal binding site [ion binding]; metal-binding site 1246995023673 putative Cl binding site [ion binding]; other site 1246995023674 basic sphincter; other site 1246995023675 hydrophobic gate; other site 1246995023676 periplasmic entrance; other site 1246995023677 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1246995023678 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 1246995023679 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1246995023680 homodimer interface [polypeptide binding]; other site 1246995023681 catalytic residue [active] 1246995023682 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1246995023683 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 1246995023684 active site 1246995023685 metal-binding site 1246995023686 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1246995023687 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1246995023688 active site 1246995023689 NAD binding site [chemical binding]; other site 1246995023690 metal binding site [ion binding]; metal-binding site 1246995023691 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1246995023692 Arylsulfotransferase (ASST); Region: Arylsulfotran_2; pfam14269 1246995023693 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1246995023694 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1246995023695 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1246995023696 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 1246995023697 putative DNA binding site [nucleotide binding]; other site 1246995023698 catalytic residue [active] 1246995023699 putative H2TH interface [polypeptide binding]; other site 1246995023700 putative catalytic residues [active] 1246995023701 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1246995023702 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1246995023703 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1246995023704 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1246995023705 Histidine kinase; Region: His_kinase; pfam06580 1246995023706 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995023707 ATP binding site [chemical binding]; other site 1246995023708 Mg2+ binding site [ion binding]; other site 1246995023709 G-X-G motif; other site 1246995023710 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1246995023711 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995023712 active site 1246995023713 phosphorylation site [posttranslational modification] 1246995023714 intermolecular recognition site; other site 1246995023715 dimerization interface [polypeptide binding]; other site 1246995023716 LytTr DNA-binding domain; Region: LytTR; smart00850 1246995023717 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1246995023718 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1246995023719 active site 1246995023720 phosphorylation site [posttranslational modification] 1246995023721 intermolecular recognition site; other site 1246995023722 dimerization interface [polypeptide binding]; other site 1246995023723 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1246995023724 DNA binding site [nucleotide binding] 1246995023725 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1246995023726 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1246995023727 dimerization interface [polypeptide binding]; other site 1246995023728 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1246995023729 dimer interface [polypeptide binding]; other site 1246995023730 phosphorylation site [posttranslational modification] 1246995023731 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995023732 ATP binding site [chemical binding]; other site 1246995023733 Mg2+ binding site [ion binding]; other site 1246995023734 G-X-G motif; other site 1246995023735 Domain of unknown function (DUF4173); Region: DUF4173; pfam13777 1246995023736 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1246995023737 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1246995023738 Na binding site [ion binding]; other site 1246995023739 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 1246995023740 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1246995023741 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1246995023742 Walker A/P-loop; other site 1246995023743 ATP binding site [chemical binding]; other site 1246995023744 Q-loop/lid; other site 1246995023745 ABC transporter signature motif; other site 1246995023746 Walker B; other site 1246995023747 D-loop; other site 1246995023748 H-loop/switch region; other site 1246995023749 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1246995023750 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1246995023751 active site 1246995023752 HIGH motif; other site 1246995023753 dimer interface [polypeptide binding]; other site 1246995023754 KMSKS motif; other site 1246995023755 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 1246995023756 Protein of unknown function, DUF485; Region: DUF485; pfam04341 1246995023757 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1246995023758 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1246995023759 Na binding site [ion binding]; other site 1246995023760 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1246995023761 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1246995023762 NAD(P) binding site [chemical binding]; other site 1246995023763 active site 1246995023764 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 1246995023765 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1246995023766 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1246995023767 active site residue [active] 1246995023768 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1246995023769 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1246995023770 active site 1246995023771 catalytic site [active] 1246995023772 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1246995023773 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1246995023774 putative active site [active] 1246995023775 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1246995023776 dimer interface [polypeptide binding]; other site 1246995023777 phosphorylation site [posttranslational modification] 1246995023778 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1246995023779 ATP binding site [chemical binding]; other site 1246995023780 Mg2+ binding site [ion binding]; other site 1246995023781 G-X-G motif; other site 1246995023782 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cd00413 1246995023783 active site 1246995023784 catalytic residues [active] 1246995023785 arginine deiminase; Provisional; Region: PRK01388 1246995023786 Family description; Region: ACT_7; pfam13840 1246995023787 prephenate dehydratase; Provisional; Region: PRK11898 1246995023788 Prephenate dehydratase; Region: PDT; pfam00800 1246995023789 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1246995023790 putative L-Phe binding site [chemical binding]; other site 1246995023791 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 1246995023792 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 1246995023793 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 1246995023794 seryl-tRNA synthetase; Provisional; Region: PRK05431 1246995023795 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1246995023796 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1246995023797 dimer interface [polypeptide binding]; other site 1246995023798 active site 1246995023799 motif 1; other site 1246995023800 motif 2; other site 1246995023801 motif 3; other site 1246995023802 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1246995023803 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1246995023804 active site 1246995023805 motif I; other site 1246995023806 motif II; other site 1246995023807 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1246995023808 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1246995023809 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1246995023810 active site 1246995023811 motif I; other site 1246995023812 motif II; other site 1246995023813 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1246995023814 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 1246995023815 Amidinotransferase; Region: Amidinotransf; cl12043 1246995023816 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 1246995023817 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1246995023818 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1246995023819 putative DNA binding site [nucleotide binding]; other site 1246995023820 putative Zn2+ binding site [ion binding]; other site 1246995023821 AsnC family; Region: AsnC_trans_reg; pfam01037 1246995023822 Beta propeller domain; Region: Beta_propel; pfam09826 1246995023823 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1246995023824 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1246995023825 PhoD-like phosphatase; Region: PhoD; pfam09423 1246995023826 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1246995023827 putative active site [active] 1246995023828 putative metal binding site [ion binding]; other site 1246995023829 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1246995023830 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 1246995023831 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1246995023832 Fructosamine kinase; Region: Fructosamin_kin; cl17579 1246995023833 Phosphotransferase enzyme family; Region: APH; pfam01636 1246995023834 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1246995023835 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1246995023836 FeS/SAM binding site; other site 1246995023837 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1246995023838 Ubiquitin-like proteins; Region: UBQ; cl00155 1246995023839 charged pocket; other site 1246995023840 hydrophobic patch; other site 1246995023841 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1246995023842 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1246995023843 putative active site [active] 1246995023844 putative metal binding site [ion binding]; other site 1246995023845 PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379 1246995023846 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1246995023847 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1246995023848 Part of AAA domain; Region: AAA_19; pfam13245 1246995023849 Family description; Region: UvrD_C_2; pfam13538 1246995023850 AAA ATPase domain; Region: AAA_16; pfam13191 1246995023851 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1246995023852 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1246995023853 Coenzyme A binding pocket [chemical binding]; other site 1246995023854 Predicted membrane protein [Function unknown]; Region: COG2259 1246995023855 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 1246995023856 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1246995023857 MoaE homodimer interface [polypeptide binding]; other site 1246995023858 MoaD interaction [polypeptide binding]; other site 1246995023859 active site residues [active] 1246995023860 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1246995023861 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1246995023862 dimer interface [polypeptide binding]; other site 1246995023863 putative functional site; other site 1246995023864 putative MPT binding site; other site 1246995023865 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1246995023866 MPT binding site; other site 1246995023867 trimer interface [polypeptide binding]; other site 1246995023868 molybdenum cofactor biosynthesis protein MoaC; Provisional; Region: moaC; PRK09364 1246995023869 trimer interface [polypeptide binding]; other site 1246995023870 dimer interface [polypeptide binding]; other site 1246995023871 putative active site [active] 1246995023872 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1246995023873 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1246995023874 metal binding site [ion binding]; metal-binding site 1246995023875 active site 1246995023876 I-site; other site 1246995023877 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1246995023878 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 1246995023879 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1246995023880 YwqJ-like deaminase; Region: YwqJ-deaminase; pfam14431 1246995023881 SUKH-3 immunity protein; Region: SUKH-3; pfam14433 1246995023882 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 1246995023883 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 1246995023884 metal binding triad [ion binding]; metal-binding site 1246995023885 replicative DNA helicase; Region: DnaB; TIGR00665 1246995023886 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1246995023887 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1246995023888 Walker A motif; other site 1246995023889 ATP binding site [chemical binding]; other site 1246995023890 Walker B motif; other site 1246995023891 DNA binding loops [nucleotide binding] 1246995023892 transcription termination factor Rho; Provisional; Region: PRK12678 1246995023893 transcription termination factor Rho; Provisional; Region: PRK12678 1246995023894 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14951 1246995023895 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1246995023896 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1246995023897 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1246995023898 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1246995023899 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1246995023900 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1246995023901 dimer interface [polypeptide binding]; other site 1246995023902 ssDNA binding site [nucleotide binding]; other site 1246995023903 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1246995023904 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1246995023905 endonuclease IV; Provisional; Region: PRK01060 1246995023906 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1246995023907 AP (apurinic/apyrimidinic) site pocket; other site 1246995023908 DNA interaction; other site 1246995023909 Metal-binding active site; metal-binding site 1246995023910 Predicted integral membrane protein [Function unknown]; Region: COG5650 1246995023911 Transglycosylase; Region: Transgly; pfam00912 1246995023912 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1246995023913 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1246995023914 Predicted transcriptional regulators [Transcription]; Region: COG1695 1246995023915 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1246995023916 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 1246995023917 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 1246995023918 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1246995023919 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1246995023920 DNA binding site [nucleotide binding] 1246995023921 active site 1246995023922 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 1246995023923 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995023924 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1246995023925 DNA binding residues [nucleotide binding] 1246995023926 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 1246995023927 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 1246995023928 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1246995023929 active site 1246995023930 NTP binding site [chemical binding]; other site 1246995023931 metal binding triad [ion binding]; metal-binding site 1246995023932 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1246995023933 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1246995023934 Zn2+ binding site [ion binding]; other site 1246995023935 Mg2+ binding site [ion binding]; other site 1246995023936 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1246995023937 integral membrane protein MviN; Region: mviN; TIGR01695 1246995023938 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1246995023939 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1246995023940 active site 1246995023941 ATP binding site [chemical binding]; other site 1246995023942 substrate binding site [chemical binding]; other site 1246995023943 activation loop (A-loop); other site 1246995023944 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 1246995023945 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1246995023946 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1246995023947 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1246995023948 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1246995023949 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1246995023950 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1246995023951 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1246995023952 catalytic residues [active] 1246995023953 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1246995023954 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1246995023955 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1246995023956 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1246995023957 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1246995023958 active site 1246995023959 metal binding site [ion binding]; metal-binding site 1246995023960 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1246995023961 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1246995023962 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1246995023963 homodimer interface [polypeptide binding]; other site 1246995023964 catalytic residue [active] 1246995023965 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1246995023966 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 1246995023967 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1246995023968 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 1246995023969 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1246995023970 ParB-like nuclease domain; Region: ParBc; pfam02195 1246995023971 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1246995023972 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1246995023973 Magnesium ion binding site [ion binding]; other site 1246995023974 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 1246995023975 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 1246995023976 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1246995023977 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1246995023978 G-X-X-G motif; other site 1246995023979 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1246995023980 RxxxH motif; other site 1246995023981 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 1246995023982 Haemolytic domain; Region: Haemolytic; pfam01809 1246995023983 Ribonuclease P; Region: Ribonuclease_P; pfam00825 1246995023984 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399